MCID: CRB004
MIFTS: 47

Cerebral Artery Occlusion

Categories: Cardiovascular diseases, Neuronal diseases
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Aliases & Classifications for Cerebral Artery Occlusion

MalaCards integrated aliases for Cerebral Artery Occlusion:

Name: Cerebral Artery Occlusion 11 14

Classifications:



External Ids:

Disease Ontology 11 DOID:10127
ICD9CM 34 434
SNOMED-CT 68 20059004
UMLS 71 C0028790

Summaries for Cerebral Artery Occlusion

Disease Ontology: 11 A cerebrovascular disease that is characterized by blockage in one or more of the cerebral arteries.

MalaCards based summary: Cerebral Artery Occlusion is related to transient cerebral ischemia and aphasia. An important gene associated with Cerebral Artery Occlusion is MIR124-1 (MicroRNA 124-1), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. The drugs Acetylsalicylic acid and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and endothelial, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and nervous system

Related Diseases for Cerebral Artery Occlusion

Diseases related to Cerebral Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 754)
# Related Disease Score Top Affiliating Genes
1 transient cerebral ischemia 31.3 PLG PLAT IL6 BCL2
2 aphasia 31.2 PLG PLAT BDNF
3 hemiplegia 30.9 PLG PLAT MMP9 EDN1
4 moyamoya disease 1 30.9 VEGFA PLG PLAT MMP9
5 cerebrovascular disease 30.8 TNF RBFOX3 PLG PLAT MIR124-1 IL6
6 intracranial embolism 30.7 PLG PLAT OCLN IL6
7 hyperglycemia 30.7 TNF IL6 HIF1A BDNF AKT1
8 carotid stenosis 30.6 VEGFA TNF MMP9
9 endocarditis 30.6 TNF PLAT IL6
10 brain edema 30.5 VEGFA MMP9 IL6 IL1B HMOX1 HIF1A
11 arteriovenous malformation 30.5 VEGFA PLG PLAT
12 nonbacterial thrombotic endocarditis 30.3 PLG PLAT
13 neutropenia 30.3 TNF IL6 IL1B BCL2 AKT1
14 erythema nodosum 30.2 TNF IL6 IL1B
15 vascular dementia 30.2 VEGFA TNF IL6 IL1B BDNF
16 common cold 30.2 TNF IL6 IL1B
17 disseminated intravascular coagulation 30.2 TNF PLG PLAT IL6
18 carotid artery occlusion 30.2 VEGFA RBFOX3 PLG PLAT IL1B CASP3
19 aspergillosis 30.1 TNF PLG IL6 IL1B
20 uveitis 30.1 VEGFA TNF IL6 IL1B
21 otitis media 30.1 TNF PLG IL6 IL1B
22 ischemia 30.1 VEGFA TNF PLG PLAT IL6 HMOX1
23 temporal arteritis 30.1 VEGFA TNF IL6 IL1B
24 microvascular complications of diabetes 5 30.0 VEGFA PLG HIF1A AKT1
25 adenomyosis 30.0 VEGFA MMP9 BCL2
26 behcet syndrome 30.0 VEGFA TNF IL6 IL1B
27 vascular disease 30.0 VEGFA TNF PLAT MMP9 IL6 HMOX1
28 asphyxia neonatorum 30.0 IL6 IL1B HIF1A CASP3 BDNF
29 major depressive disorder 29.9 TNF IL6 IL1B GDNF BDNF AKT1
30 sickle cell anemia 29.9 TNF IL6 HMOX1 EDN1
31 tetanus 29.8 TNF IL6 IL1B GDNF
32 huntington disease 29.8 VEGFA GDNF CASP3 BDNF AKT1
33 tongue carcinoma 29.7 VEGFA MMP9 CASP3 BCL2 AKT1
34 myelodysplastic syndrome 29.7 VEGFA TNF IL6 IL1B CASP3 BCL2
35 acute myocardial infarction 29.7 VEGFA TNF PLAT MMP9 IL6 EDN1
36 arteriosclerosis 29.7 MMP9 IL6 HMOX1 HIF1A EDN1
37 autism spectrum disorder 29.7 TNF IL6 IL1B CASP3 BDNF AKT1
38 sleep disorder 29.6 TNF IL6 IL1B HIF1A EDN1 BDNF
39 encephalomalacia 29.6 VEGFA TNF RBFOX3 IL6 IL1B CASP3
40 myeloma, multiple 29.6 VEGFA IL6 IL1B CASP3 BDNF BCL2
41 stroke, ischemic 29.6 VEGFA TNF RBFOX3 PLG PLAT MMP9
42 arteries, anomalies of 29.6 VEGFA TNF PLG MIR124-1 IL6 IL1B
43 hydrocephalus 29.5 VEGFA TNF PLAT GDNF CASP3 BDNF
44 congestive heart failure 29.5 VEGFA TNF MMP9 IL6 IL1B EDN1
45 lung cancer susceptibility 3 29.5 VEGFA MMP9 HIF1A CASP3 BCL2 AKT1
46 apnea, obstructive sleep 29.4 VEGFA TNF IL6 IL1B HIF1A EDN1
47 retinal vascular disease 29.4 VEGFA TNF PLG IL6 IL1B HIF1A
48 central nervous system disease 29.4 MMP9 MIR124-1 HMOX1 BDNF
49 autism 29.3 TNF MMP9 IL6 IL1B CASP3 BDNF
50 narcolepsy 29.2 VEGFA TNF IL6 IL1B GDNF BDNF

Graphical network of the top 20 diseases related to Cerebral Artery Occlusion:



Diseases related to Cerebral Artery Occlusion

Symptoms & Phenotypes for Cerebral Artery Occlusion

GenomeRNAi Phenotypes related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.8 AKT1 CASP3 HIF1A IL1B RBFOX3 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.8 AKT1 CASP3 GDNF HIF1A HMOX1 IL1B
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.8 HIF1A

MGI Mouse Phenotypes related to Cerebral Artery Occlusion:

45 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.56 AIF1 AKT1 BCL2 BDNF CASP3 CLDN5
2 homeostasis/metabolism MP:0005376 10.49 AIF1 AKT1 BCL2 BDNF CASP3 EDN1
3 growth/size/body region MP:0005378 10.48 AIF1 AKT1 BCL2 BDNF CASP3 EDN1
4 muscle MP:0005369 10.38 AKT1 BCL2 CASP3 EDN1 GDNF HIF1A
5 endocrine/exocrine gland MP:0005379 10.38 AKT1 BCL2 BDNF CASP3 EDN1 GDNF
6 cardiovascular system MP:0005385 10.38 AIF1 AKT1 BCL2 CASP3 CLDN5 EDN1
7 cellular MP:0005384 10.37 AKT1 BCL2 BDNF CASP3 GDNF HIF1A
8 digestive/alimentary MP:0005381 10.34 BCL2 BDNF CASP3 EDN1 GDNF HIF1A
9 behavior/neurological MP:0005386 10.33 AKT1 BCL2 BDNF CASP3 GDNF HIF1A
10 immune system MP:0005387 10.31 AIF1 AKT1 BCL2 CASP3 GDNF HIF1A
11 renal/urinary system MP:0005367 10.27 BCL2 CASP3 EDN1 GDNF HIF1A HMOX1
12 neoplasm MP:0002006 10.24 AKT1 BCL2 HIF1A IL1B IL6 MMP9
13 craniofacial MP:0005382 10.21 BCL2 BDNF CASP3 EDN1 HIF1A HMOX1
14 reproductive system MP:0005389 10.18 AKT1 BCL2 BDNF CASP3 GDNF HMOX1
15 respiratory system MP:0005388 10.14 AKT1 BDNF CASP3 HIF1A HMOX1 IL6
16 skeleton MP:0005390 10.1 AIF1 AKT1 CASP3 EDN1 HIF1A IL1B
17 vision/eye MP:0005391 10.07 AIF1 BCL2 BDNF CASP3 HIF1A HMOX1
18 hematopoietic system MP:0005397 10 AIF1 AKT1 BCL2 CASP3 GDNF HIF1A
19 mortality/aging MP:0010768 9.91 AKT1 BCL2 BDNF CASP3 CLDN5 EDN1
20 integument MP:0010771 9.44 AKT1 BCL2 BDNF CASP3 HIF1A IL1B

Drugs & Therapeutics for Cerebral Artery Occlusion

Drugs for Cerebral Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylsalicylic acid Approved, Vet_approved Phase 3 50-78-2 2244
2
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
3 Fibrinolytic Agents Phase 3
4 Analgesics Phase 3
5 Neurotransmitter Agents Phase 3
6 Antirheumatic Agents Phase 3
7 Antipyretics Phase 3
8 Purinergic P2Y Receptor Antagonists Phase 3
9 Cyclooxygenase Inhibitors Phase 3
10 Platelet Aggregation Inhibitors Phase 3
11 Anti-Inflammatory Agents, Non-Steroidal Phase 3
12 Anti-Inflammatory Agents Phase 3
13 Analgesics, Non-Narcotic Phase 3
14 Complement System Proteins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Completed NCT01758614 Phase 3 Aspirin;Clopidogrel
2 Randomized Therapeutic Study Assessing the Superiority of a Sequential Intravenous Thrombolysis Treatment (Rt-PA + Tenecteplase) in Comparison With Rt-PA Standard Treatment in Proximal Middle Cerebral Artery Occlusion (DIVA). Withdrawn NCT02338466 Phase 2 rt-PA;tenecteplase
3 Evaluation of Clinical Results of Treatment of Cerebral Artery Occlusion by Mechanical Thrombectomy, in the Acute Phase of Stroke Completed NCT02880579
4 Safety and Efficacy of Remote Ischemic Conditioning in Patients With Chronic Cerebral Artery Occlusion: A Prospective, Randomized, Controlled Study Recruiting NCT05342714
5 Acute Anterior or Posterior Cerebral Artery Occlusion Recanalization Therapy and Relationships With Clinical Outcome (ACAPULCO) Recruiting NCT04823481
6 Endovascular Therapy vs Medical Management of PosterIor Cerebral Artery Occlusion Stroke Recruiting NCT05291637
7 HEADS: UP (Helping Ease Anxiety and Depression Following Stroke) Psychological Self-management Intervention: a Randomised Controlled Pilot Trial Active, not recruiting NCT04985838

Search NIH Clinical Center for Cerebral Artery Occlusion

Genetic Tests for Cerebral Artery Occlusion

Anatomical Context for Cerebral Artery Occlusion

Organs/tissues related to Cerebral Artery Occlusion:

MalaCards : Brain, Bone Marrow, Endothelial, Bone, Cortex, Thalamus, Spinal Cord

Publications for Cerebral Artery Occlusion

Articles related to Cerebral Artery Occlusion:

(show top 50) (show all 13077)
# Title Authors PMID Year
1
Overexpression of vascular endothelial growth factor enhances the neuroprotective effects of bone marrow mesenchymal stem cell transplantation in ischemic stroke. 62
36453413 2023
2
Stimulation of functional recovery via neurorepair mechanisms by the traditional Japanese Kampo medicine, Ninjin'yoeito, and physical exercise in a rat ischemic stroke model. 62
36402237 2023
3
Neural stem cell-derived exosome as a nano-sized carrier for BDNF delivery to a rat model of ischemic stroke. 62
35900437 2023
4
Cranial electrotherapy stimulation alleviates depression-like behavior of post-stroke depression rats by upregulating GPX4-mediated BDNF expression. 62
36116735 2023
5
CRS induces depression-like behavior after MCAO in rats possibly by activating p38 MAPK. 62
36100011 2023
6
Cholestyramine resin administration alleviated cerebral ischemic injury in obese mice by improving gut dysbiosis and modulating the bile acid profile. 62
36179877 2023
7
Protective effect of Xingnaojing injection on ferroptosis after cerebral ischemia injury in MCAO rats and SH-SY5Y cells. 62
36252877 2023
8
RGD1564534 represses NLRP3 inflammasome activity in cerebral injury following ischemia-reperfusion by impairing miR-101a-3p-mediated Dusp1 inhibition. 62
36336032 2023
9
Danhong injection alleviates cerebral ischemia-reperfusion injury by inhibiting autophagy through miRNA-132-3p/ATG12 signal axis. 62
36115599 2023
10
Antihypertension effect of astragaloside IV during cerebral ischemia reperfusion in rats. 62
36331022 2023
11
Administration of intramuscular AAV-BDNF and intranasal AAV-TrkB promotes neurological recovery via enhancing corticospinal synaptic connections in stroke rats. 62
36183811 2023
12
Efficacy of curculigoside in protecting against ischemic brain injury through regulation of oxidative stress and NF-κB and PI3K/Akt expression. 62
36228892 2023
13
Metabolomic analysis and pharmacological validation of the cerebral protective effect of 3,4‑dihydroxybenzaldehyde on cerebral ischemia‑reperfusion injury. 62
36367170 2023
14
Gadolinium retention in the ischemic cerebrum: Implications for pain, neuron loss, and neurological deficits. 62
36111354 2023
15
Combination of EPC-EXs and NPC-EXs with miR-126 and miR-210 overexpression produces better therapeutic effects on ischemic stroke by protecting neurons through the Nox2/ROS and BDNF/TrkB pathways. 62
36174747 2023
16
Therapeutic applications of hydrogen sulfide and novel donors for cerebral ischemic stroke: a narrative review. 62
35946216 2023
17
Integrating network pharmacology and pharmacological evaluation to explore the protective mechanism of Ershiwuwei Zhenzhu pill in ischemic stroke. 62
36272491 2023
18
Chronic intermittent hypoxia worsens brain damage and sensorimotor behavioral abnormalities after ischemic stroke: Effect on autonomic nervous activity and sleep patterns. 62
36370768 2023
19
Zhachong Shisanwei Pill resists ischemic stroke by lysosome pathway based on proteomics and bioinformatics. 62
36183948 2023
20
Neuroprotection of boropinol-B in cerebral ischemia-reperfusion injury by inhibiting inflammation and apoptosis. 62
36341903 2023
21
The p75 neurotrophin receptor inhibitor, LM11A-31, ameliorates acute stroke injury and modulates astrocytic proNGF. 62
35787888 2023
22
Therapeutic effects of JLX001 on neuronal necroptosis after cerebral ischemia-reperfusion in rats. 62
36255461 2022
23
Para‑hydroxybenzaldehyde against transient focal cerebral ischemia in rats via mitochondrial preservation. 62
36382091 2022
24
Combination of paeoniflorin and calycosin-7-glucoside alleviates ischaemic stroke injury via the PI3K/AKT signalling pathway. 62
35938509 2022
25
The therapeutic role of Jingchuan tablet on ischaemic cerebral stroke via the HIF-1α/EPO/VEGFA signalling pathway. 62
36269045 2022
26
Circ_0101874 overexpression strengthens PDE4D expression by targeting miR-335-5p to promote neuronal injury in ischemic stroke. 62
36252429 2022
27
Axin1 participates in blood-brain barrier protection during experimental ischemic stroke via phosphorylation at Thr485 in rats. 62
36464067 2022
28
MMP-12 knockdown prevents secondary brain damage after ischemic stroke in mice. 62
36252818 2022
29
Anti-osteopontin therapy leads to improved edema and infarct size in a murine model of ischemic stroke. 62
36463381 2022
30
Lumbrokinase regulates endoplasmic reticulum stress to improve neurological deficits in ischemic stroke. 62
36223864 2022
31
Edaravone dexborneol provides neuroprotective benefits by suppressing NLRP3 inflammasome-induced microglial pyroptosis in experimental ischemic stroke. 62
36279668 2022
32
Bim Deletion Reduces Functional Deficits Following Ischemic Stroke in Association with Modulation of Apoptosis and Inflammation. 62
35149957 2022
33
Spatial Analysis of Neural Cell Proteomic Profiles Following Ischemic Stroke in Mice Using High-Plex Digital Spatial Profiling. 62
36151369 2022
34
Detrimental effects of transient cerebral ischemia on middle cerebral artery mitochondria in female rats. 62
36367688 2022
35
Transplantation of modified human bone marrow-derived stromal cells affords therapeutic effects on cerebral ischemia in rats. 62
36000240 2022
36
Lomitapide ameliorates middle cerebral artery occlusion-induced cerebral ischemia/reperfusion injury by promoting neuronal autophagy and inhibiting microglial migration. 62
36052650 2022
37
Fingolimod Does Not Reduce Infarction After Focal Cerebral Ischemia in Mice During Active or Inactive Circadian Phases. 62
36252110 2022
38
Effect of early Sanguinate (PEGylated carboxyhemoglobin bovine) infusion on cerebral blood flow to the ischemic core in experimental middle cerebral artery occlusion. 62
34907008 2022
39
Folium Ginkgo extract and tetramethylpyrazine sodium chloride injection (Xingxiong injection) protects against focal cerebral ischaemia/reperfusion injury via activating the Akt/Nrf2 pathway and inhibiting NLRP3 inflammasome activation. 62
35060427 2022
40
Silencing of Long Noncoding RNA GAS5 Blocks Experimental Cerebral Ischemia-Reperfusion Injury by Restraining AQP4 Expression via the miR-1192/STAT5A Axis. 62
36195691 2022
41
Delavatine A Attenuates OGD/R-Caused PC12 Cell Injury and Apoptosis through Suppressing the MKK7/JNK Signaling Pathway. 62
36130913 2022
42
Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative stress and apoptosis via Nrf2/Trx1 signaling pathway. 62
35976554 2022
43
Sphingosine-1-phosphate receptor modulation improves neurogenesis and functional recovery after stroke. 62
36394527 2022
44
MicroRNA-27a Regulates Ferroptosis Through SLC7A11 to Aggravate Cerebral ischemia-reperfusion Injury. 62
36456793 2022
45
Quasi-steady-state amide proton transfer (QUASS APT) MRI enhances pH-weighted imaging of acute stroke. 62
36178234 2022
46
Nano-integrated cascade antioxidases opsonized by albumin bypass the blood-brain barrier for treatment of ischemia-reperfusion injury. 62
36341569 2022
47
Mechanism of Huangqi-Honghua combination regulating the gut microbiota to affect bile acid metabolism towards preventing cerebral ischaemia-reperfusion injury in rats. 62
36307999 2022
48
Investigation of Naoluoxintong on the neural stem cells by facilitating proliferation and differentiation in vitro and on protecting neurons by up-regulating the expression of nestin in MCAO rats. 62
36058480 2022
49
Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles. 62
36038749 2022
50
MiR-182 Inhibition Protects Against Experimental Stroke in vivo and Mitigates Astrocyte Injury and Inflammation in vitro via Modulation of Cortactin Activity. 62
35951202 2022

Variations for Cerebral Artery Occlusion

Expression for Cerebral Artery Occlusion

Search GEO for disease gene expression data for Cerebral Artery Occlusion.

Pathways for Cerebral Artery Occlusion

Pathways related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 TNF PLG MMP9 IL6 IL1B CASP3
2
Show member pathways
13.88 AKT1 BCL2 BDNF CASP3 HIF1A IL1B
3 13.78 AKT1 BCL2 BDNF CASP3 EDN1 GDNF
4
Show member pathways
13.66 VEGFA TNF MMP9 IL6 IL1B GDNF
5
Show member pathways
13.46 TNF IL6 IL1B CASP3 BDNF BCL2
6
Show member pathways
13.36 TNF IL6 IL1B CASP3 BDNF BCL2
7
Show member pathways
13.36 VEGFA TNF MMP9 IL6 IL1B HMOX1
8
Show member pathways
13.01 VEGFA IL6 HIF1A BDNF BCL2 AKT1
9
Show member pathways
12.9 TNF MMP9 IL6 IL1B CASP3 BCL2
10
Show member pathways
12.89 TNF IL6 IL1B CASP3 AKT1
11 12.89 AKT1 BDNF HIF1A MMP9 PLAT PLG
12
Show member pathways
12.8 VEGFA PLG PLAT HIF1A AKT1
13
Show member pathways
12.77 AKT1 BDNF IL1B IL6 TNF
14
Show member pathways
12.73 OCLN IL1B CASP3 BCL2 AKT1
15
Show member pathways
12.69 AKT1 BDNF CASP3 IL1B IL6 TNF
16 12.69 VEGFA MMP9 IL6 IL1B HIF1A BDNF
17
Show member pathways
12.68 EDN1 HMOX1 IL1B IL6 TNF
18
Show member pathways
12.68 TNF IL1B CASP3 BDNF BCL2 AKT1
19
Show member pathways
12.65 TNF PLG IL6 IL1B BCL2 AKT1
20
Show member pathways
12.52 VEGFA OCLN MMP9 CLDN5 AKT1
21
Show member pathways
12.48 IL1B CASP3 BCL2 AKT1
22 12.46 TNF IL1B CASP3 BDNF AKT1
23
Show member pathways
12.42 TNF CASP3 BCL2 AKT1
24
Show member pathways
12.4 TNF CASP3 BCL2 AKT1
25
Show member pathways
12.37 TNF IL6 IL1B AKT1
26
Show member pathways
12.34 TNF MMP9 IL6 CASP3 AKT1
27
Show member pathways
12.27 HIF1A CASP3 BCL2 AKT1
28
Show member pathways
12.26 GDNF BDNF BCL2 AKT1
29 12.26 VEGFA TNF MMP9 IL6 CASP3 AKT1
30 12.24 OCLN MMP9 HIF1A CLDN5 AKT1
31 12.2 VEGFA CASP3 BCL2 AKT1
32 12.13 VEGFA HIF1A BCL2 AKT1
33 12.13 AKT1 BCL2 BDNF IL1B IL6 TNF
34 12.11 VEGFA TNF IL6 IL1B HIF1A CASP3
35
Show member pathways
12.1 VEGFA PLAT MMP9 AKT1
36
Show member pathways
12.09 TNF CASP3 BCL2 AKT1
37 12 PLAT IL6 IL1B BCL2
38 11.96 CASP3 GDNF IL1B TNF VEGFA
39 11.88 VEGFA HIF1A AKT1
40 11.85 IL6 BCL2 AKT1
41
Show member pathways
11.85 IL6 HIF1A CASP3 AKT1
42 11.84 BDNF GDNF VEGFA
43 11.82 AIF1 BDNF CASP3 GDNF IL1B IL6
44 11.81 TNF IL6 IL1B
45 11.79 MMP9 IL6 HIF1A EDN1
46 11.77 IL6 IL1B HIF1A
47
Show member pathways
11.77 AKT1 BDNF CASP3 PLG
48
Show member pathways
11.75 MMP9 BDNF AKT1
49 11.75 VEGFA HMOX1 HIF1A EDN1 AKT1
50 11.72 TNF IL6 IL1B

GO Terms for Cerebral Artery Occlusion

Cellular components related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.66 VEGFA TNF PLG PLAT MMP9 IL6

Biological processes related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 49)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.43 AKT1 CLDN5 HIF1A IL1B IL6 OCLN
2 positive regulation of cell population proliferation GO:0008284 10.43 VEGFA IL6 IL1B GDNF EDN1 CLDN5
3 apoptotic process GO:0006915 10.37 AKT1 BCL2 CASP3 HIF1A HMOX1 IL1B
4 response to xenobiotic stimulus GO:0009410 10.34 TNF HMOX1 EDN1 CASP3 BCL2
5 negative regulation of cell population proliferation GO:0008285 10.34 BCL2 HMOX1 IL1B IL6 PLG TNF
6 negative regulation of gene expression GO:0010629 10.34 VEGFA TNF OCLN HIF1A EDN1 CLDN5
7 positive regulation of protein phosphorylation GO:0001934 10.33 AIF1 AKT1 IL1B MMP9 TNF VEGFA
8 cellular response to hypoxia GO:0071456 10.27 BCL2 EDN1 HIF1A HMOX1 VEGFA
9 positive regulation of DNA-binding transcription factor activity GO:0051091 10.27 TNF IL6 IL1B EDN1 AKT1
10 positive regulation of interleukin-6 production GO:0032755 10.26 TNF IL6 IL1B AIF1
11 negative regulation of neuron apoptotic process GO:0043524 10.24 HMOX1 HIF1A GDNF BDNF BCL2
12 positive regulation of MAP kinase activity GO:0043406 10.22 EDN1 IL1B TNF VEGFA
13 I-kappaB kinase/NF-kappaB signaling GO:0007249 10.2 TNF IL1B EDN1 AKT1
14 response to glucocorticoid GO:0051384 10.19 AIF1 BCL2 CASP3 IL6 TNF
15 negative regulation of apoptotic process GO:0043066 10.19 VEGFA TNF MMP9 IL6 HIF1A GDNF
16 response to hydrogen peroxide GO:0042542 10.18 HMOX1 CASP3 BCL2
17 positive regulation of blood vessel endothelial cell migration GO:0043536 10.18 VEGFA HIF1A AKT1
18 positive regulation of peptidyl-serine phosphorylation GO:0033138 10.18 AKT1 BCL2 BDNF IL6 TNF VEGFA
19 lipopolysaccharide-mediated signaling pathway GO:0031663 10.17 AKT1 IL1B TNF
20 cellular response to cadmium ion GO:0071276 10.16 MMP9 HMOX1 AKT1
21 negative regulation of apoptotic signaling pathway GO:2001234 10.16 TNF BDNF BCL2
22 positive regulation of nitric oxide biosynthetic process GO:0045429 10.16 AIF1 AKT1 EDN1 IL1B TNF
23 maintenance of blood-brain barrier GO:0035633 10.15 CLDN5 IL6 OCLN
24 response to hypoxia GO:0001666 10.15 VEGFA TNF PLAT HMOX1 HIF1A EDN1
25 positive regulation of mitotic nuclear division GO:0045840 10.14 TNF IL1B EDN1
26 liver regeneration GO:0097421 10.14 HMOX1 IL6 TNF
27 response to nicotine GO:0035094 10.14 HMOX1 EDN1 CASP3 BCL2
28 positive regulation of vascular endothelial growth factor production GO:0010575 10.13 IL6 IL1B HIF1A
29 response to amino acid GO:0043200 10.12 EDN1 CASP3 BCL2
30 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.11 HIF1A IL6 TNF
31 negative regulation of neurogenesis GO:0050768 10.11 TNF IL6 IL1B
32 positive regulation of nitric-oxide synthase activity GO:0051000 10.1 TNF HIF1A AKT1
33 positive regulation of glial cell proliferation GO:0060252 10.09 TNF IL6 IL1B
34 epithelial cell apoptotic process GO:1904019 10.08 HMOX1 CASP3 BCL2
35 cellular response to organic substance GO:0071310 10.05 IL1B EDN1 CASP3 BCL2
36 negative regulation of intrinsic apoptotic signaling pathway GO:2001243 10.04 MMP9 BCL2 AKT1
37 positive regulation of neuroinflammatory response GO:0150078 10.03 TNF IL6 IL1B
38 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 10.02 AKT1 BCL2 GDNF IL1B TNF
39 positive regulation of mononuclear cell migration GO:0071677 10 TNF AIF1
40 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 10 VEGFA HIF1A
41 positive regulation of fever generation GO:0031622 10 TNF IL1B
42 sequestering of triglyceride GO:0030730 9.98 TNF IL1B
43 trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 9.98 PLG PLAT
44 leukocyte migration GO:0050900 9.97 IL1B MMP9 TNF
45 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.95 TNF IL1B
46 positive regulation of chemokine-mediated signaling pathway GO:0070101 9.92 HIF1A EDN1
47 vascular endothelial growth factor production GO:0010573 9.76 HIF1A IL1B IL6 TNF
48 positive regulation of smooth muscle cell proliferation GO:0048661 9.73 TNF IL6 HMOX1 EDN1 AKT1 AIF1
49 positive regulation of chemokine production GO:0032722 9.36 TNF IL6 IL1B HMOX1 HIF1A AIF1

Molecular functions related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.65 VEGFA TNF IL6 IL1B EDN1
2 signaling receptor binding GO:0005102 9.32 TNF PLG PLAT IL6 GDNF EDN1

Sources for Cerebral Artery Occlusion

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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