Cerebral Artery Occlusion disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CRB004 MIFTS: 46	Cerebral Artery Occlusion Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Cerebral Artery Occlusion

MalaCards integrated aliases for Cerebral Artery Occlusion:

Name: Cerebral Artery Occlusion ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:10127

ICD9CM ³⁶ 434 434.9

SNOMED-CT ⁶⁹ 20059004

UMLS ⁷⁴ C0028790

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Summaries for Cerebral Artery Occlusion

MalaCards based summary : Cerebral Artery Occlusion is related to brain injury and stroke, ischemic. An important gene associated with Cerebral Artery Occlusion is BDNF (Brain Derived Neurotrophic Factor), and among its related pathways/superpathways are PEDF Induced Signaling and G-Beta Gamma Signaling. The drugs Abciximab and Fibrinolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and endothelial, and related phenotypes are cellular and behavior/neurological

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Related Diseases for Cerebral Artery Occlusion

Diseases related to Cerebral Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)

#	Related Disease	Score	Top Affiliating Genes
1	brain injury	31.0	APOE BDNF
2	stroke, ischemic	30.6	APOE GDNF NOS3
3	ischemia	10.8
4	brain edema	10.5
5	peripheral vascular disease	10.3
6	hypoxia	10.3
7	hyperglycemia	10.2
8	drug-induced hearing loss	10.2	BDNF GDNF
9	brain ischemia	10.2
10	depression	10.2
11	traumatic brain injury	10.2	APOE BDNF
12	intracranial vasospasm	10.2	APOE NOS3
13	brachial plexus lesion	10.1	BDNF GDNF
14	hemiplegia	10.1
15	ischemic heart disease	10.1	APOE NOS3
16	ocular dominance	10.1	BDNF NOS1
17	tetrahydrobiopterin deficiency	10.1	NOS1 NOS3
18	mutism	10.1
19	akinetic mutism	10.1
20	carotid artery dissection	10.1
21	alzheimer's disease 1	10.1	APOE NOS1
22	alzheimer disease 2	10.1	APOE NOS3
23	sexual disorder	10.1	NOS1 NOS3
24	renovascular hypertension	10.0	NOS1 NOS3
25	moyamoya disease 1	10.0
26	cerebral hemorrhage	10.0
27	endocarditis	10.0
28	wallerian degeneration	10.0	CNTF ODC1
29	nervous system disease	10.0	APOE BDNF GDNF
30	pyloric stenosis	10.0	GDNF NOS1
31	acute vascular insufficiency of intestine	9.9	GDNF MAPK1
32	insulin-like growth factor i	9.9
33	hemorrhage, intracerebral	9.9
34	neonatal stroke	9.9
35	infective endocarditis	9.9
36	thrombosis	9.9
37	pertussis	9.9
38	hypoglycemia	9.9
39	cerebral hypoxia	9.9
40	jejunoileitis	9.9	GDNF NOS1 NOS3
41	respiratory allergy	9.9	NOS1 NOS3
42	motor neuron disease	9.9	BDNF CNTF GDNF
43	aphasia	9.8	APOE BDNF
44	cerebral amyloid angiopathy, cst3-related	9.8
45	arteries, anomalies of	9.8
46	glioma susceptibility 1	9.8
47	retinoblastoma	9.8
48	neutrophil actin dysfunction	9.8
49	retinitis pigmentosa	9.8
50	sjogren syndrome	9.8

Graphical network of the top 20 diseases related to Cerebral Artery Occlusion:

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Symptoms & Phenotypes for Cerebral Artery Occlusion

MGI Mouse Phenotypes related to Cerebral Artery Occlusion:

⁴⁷ (show all 13)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.11	APOE BDNF CNTF GDNF MAPK1 NOS1
2	behavior/neurological	MP:0005386	10.07	APOE BDNF CNTF GDNF MAPK1 NOS1
3	growth/size/body region	MP:0005378	10	APOE BDNF GDNF MAPK1 NOS1 NOS3
4	hematopoietic system	MP:0005397	9.98	APOE CNTF GDNF IL16 MAPK1 NOS1
5	digestive/alimentary	MP:0005381	9.97	APOE BDNF GDNF MAPK1 NOS1 NOS3
6	endocrine/exocrine gland	MP:0005379	9.95	APOE BDNF GDNF MAPK1 NOS1 NOS3
7	immune system	MP:0005387	9.95	APOE CNTF GDNF IL16 MAPK1 NOS1
8	nervous system	MP:0003631	9.87	APOE BDNF CNTF GDNF MAPK1 NOS1
9	muscle	MP:0005369	9.85	APOE CNTF GDNF MAPK1 NOS1 NOS3
10	reproductive system	MP:0005389	9.73	APOE BDNF GDNF MAPK1 NOS1 NOS3
11	respiratory system	MP:0005388	9.55	APOE BDNF MAPK1 NOS1 NOS3
12	taste/olfaction	MP:0005394	9.13	APOE BDNF MAPK1
13	vision/eye	MP:0005391	9.02	APOE BDNF MAPK1 NOS1 NOS3

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Drugs & Therapeutics for Cerebral Artery Occlusion

Drugs for Cerebral Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Abciximab

Approved

Phase 4

143653-53-6

Fibrinolytic Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Tissue Plasminogen Activator

Phase 4,Phase 3,Phase 2,Not Applicable

Platelet Aggregation Inhibitors

Phase 4,Phase 3,Phase 2

Plasminogen

Phase 4,Phase 2,Not Applicable

Anticoagulants

Phase 4,Phase 2

Mitogens

Phase 4

Clopidogrel

Approved

Phase 3

120202-66-6, 113665-84-2

60606

Aspirin

Approved, Vet_approved

Phase 3

50-78-2

2244

Purinergic P2Y Receptor Antagonists

Phase 3

Antirheumatic Agents

Phase 3

Analgesics, Non-Narcotic

Phase 3

Analgesics

Phase 3

Purinergic P2 Receptor Antagonists

Phase 3

Anti-Inflammatory Agents, Non-Steroidal

Phase 3

Antipyretics

Phase 3

Neurotransmitter Agents

Phase 3

Cyclooxygenase Inhibitors

Phase 3

Anti-Inflammatory Agents

Phase 3

Peripheral Nervous System Agents

Phase 3

Tenecteplase

Approved

Phase 2

191588-94-0

Iron

Approved, Experimental

Phase 2

7439-89-6, 15438-31-0

23925 27284

Deferoxamine

Approved, Investigational

Phase 2

70-51-9

2973

Argatroban

Approved, Investigational

Phase 2

74863-84-6

152951

Serine

Approved, Nutraceutical

Phase 2

56-45-1

5951

Pharmaceutical Solutions

Phase 2

Chelating Agents

Phase 2

Iron Chelating Agents

Phase 2

Siderophores

Phase 2

Antithrombin III

Phase 2

Serine Proteinase Inhibitors

Phase 2

HIV Protease Inhibitors

Phase 2

Antithrombins

Phase 2

protease inhibitors

Phase 2

Warfarin

Approved

81-81-2

6691 54678486

Dabigatran

Investigational

211914-51-1

Interventional clinical trials:

(show all 12)

#	Name	Status	NCT ID	Phase	Drugs
1	A Randomized Double Blind Placebo Control Study of Huang-Chi-Wu-Wu- Tang in Patients With Intracranial Arterial Stenosis	Unknown status	NCT01553643	Phase 4	Chinese Herb Huang-Chi-Wu-Wu-Tang;placebo
2	Thrombectomy Under Reopro Versus Alteplase to Treat Stoke	Terminated	NCT02016547	Phase 4	alteplase 0.9mg/kg (10% by IV bolus following by 90% by 1 hour IV drip)
3	Effects of Intranasal Nerve Growth Factor for Acute Ischemic Stroke	Recruiting	NCT03686163	Phase 4	Nerve Growth Factors;normal saline
4	The Carotid and Middle Cerebral Artery Occlusion Surgery Study	Unknown status	NCT01758614	Phase 3	Aspirin;Clopidogrel
5	Ultrasound Enhanced Thrombolytic Therapy of Middle Cerebral Artery Occlusion	Unknown status	NCT00336596	Phase 3
6	Superiority of Rt-PA + Tenecteplase in Comparison With Rt-PA Only in Proximal Middle Cerebral Artery Occlusion	Withdrawn	NCT02338466	Phase 2	rt-PA;tenecteplase
7	Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion	Completed	NCT00777140	Phase 2	Deferoxamine
8	Safety and Feasibility of Argatroban, Tissue Plasminogen Activator and Intra-arterial Therapy in Stroke	Completed	NCT02448069	Phase 2	Argatroban
9	Neurothrombectomy France	Completed	NCT02880579
10	Embolectomy in Acute SYlvian Thrombosis in Refractory or Ineligible Patients to ALteplase	Terminated	NCT02216565	Not Applicable	Alteplase if patient is eligible
11	The Comparative Safety and Effectiveness of Warfarin and Dabigatran Prescribed in the Non-valvular Atrial Fibrillation Population With Humana Healthcare Coverage	Completed	NCT02061748		Observational
12	Berlin PRehospital Or Usual Delivery of Acute Stroke Care	Recruiting	NCT02869386	Not Applicable

Search NIH Clinical Center for Cerebral Artery Occlusion

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Genetic Tests for Cerebral Artery Occlusion

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Anatomical Context for Cerebral Artery Occlusion

MalaCards organs/tissues related to Cerebral Artery Occlusion:

⁴²

Brain, Cortex, Endothelial, Bone, Spinal Cord, Thalamus, Neutrophil

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Publications for Cerebral Artery Occlusion

Articles related to Cerebral Artery Occlusion:

(show top 50) (show all 1677)

#	Title	Authors	Year
1	Using the behavioral flexibility operant task to detect long-term deficits in rats following middle cerebral artery occlusion. ( 30107224 )	Andrews MMM...Dunbar GL	2019
2	Oncostatin M-induced upregulation of SDF-1 improves Bone marrow stromal cell migration in a rat middle cerebral artery occlusion stroke model. ( 30213507 )	Han J...Jiang X	2019
3	'Governor vessel-unblocking and mind-regulating' acupuncture therapy ameliorates cognitive dysfunction in a rat model of middle cerebral artery occlusion. ( 30431067 )	Su X...Zhu J	2019
4	An enriched environment promotes synaptic plasticity and cognitive recovery after permanent middle cerebral artery occlusion in mice. ( 30539814 )	Wang CJ...Wang YY	2019
5	Successful double mechanical thrombectomy in bilateral M1 middle cerebral artery occlusion. ( 30637667 )	London D...Deprez FC	2019
6	Bridging Therapy Versus Direct Mechanical Thrombectomy in Patients with Acute Ischemic Stroke due to Middle Cerebral Artery Occlusion: A Clinical-Histological Analysis of Retrieved Thrombi. ( 30654640 )	Gong L...Liu X	2019
7	Amide proton transfer-weighted MRI can detect tissue acidosis and monitor recovery in a transient middle cerebral artery occlusion model compared with a permanent occlusion model in rats. ( 30666450 )	Park JE...Woo DC	2019
8	Increased expression of thymic stromal lymphopoietin receptor in a rat model of middle cerebral artery occlusion. ( 30676545 )	Yu X...Liang H	2019
9	Effects of thrombolysis within 6 hours on acute cerebral infarction in an improved rat embolic middle cerebral artery occlusion model for ischaemic stroke. ( 30697923 )	Si Z...Wang A	2019
10	A novel rat model of cerebral artery occlusion complicated with prior venous stagnation. ( 30703390 )	Zhang NN...Chen HS	2019
11	Middle Cerebral Artery Occlusion Allowing Reperfusion via Common Carotid Artery Repair in Mice. ( 30735149 )	Trotman-Lucas M...Gibson CL	2019
12	Spreading depolarization and neuronal damage or survival in mouse neocortical brain slices immediately and 12 hours following middle cerebral artery occlusion. ( 30811255 )	Petrin D...Andrew RD	2019
13	Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion. ( 30816157 )	Arroja MMC...McCabe C	2019
14	Correction to: Human adipose-derived stem cells partially rescue the stroke syndromes by promoting spatial learning and memory in mouse middle cerebral artery occlusion model. ( 30841898 )	Zhou F...Chen X	2019
15	Development of a Novel Canine Model of Ischemic Stroke: Skull Base Approach with Transient Middle Cerebral Artery Occlusion. ( 30898757 )	Vasquez CA...Grande AW	2019
16	A Genome-Wide Analysis of the Penumbral Volume in Inbred Mice following Middle Cerebral Artery Occlusion. ( 30911049 )	Rudy RF...Du R	2019
17	Identification and functional analysis of circular RNAs induced in rats by middle cerebral artery occlusion. ( 30914324 )	Duan X...Peng D	2019
18	Progression of vasogenic edema induced by activated microglia under permanent middle cerebral artery occlusion. ( 29353043 )	Tanaka M....Itoh K.	2018
19	Middle Cerebral Artery Occlusion by an Intraluminal Suture Method. ( 29222799 )	Crupi R....Cuzzocrea S.	2018
20	Dietary nitrate supplementation reduces low frequency blood pressure fluctuations in rats following distal middle cerebral artery occlusion. ( 29856262 )	Allan P.D....Fan J.L.	2018
21	Acute Right Middle Cerebral Artery Occlusion Resulting in Acute Systolic Heart Failure, Cerebral T-Waves, and QTc Prolongation: A Case Report. ( 29953038 )	Blech B....O'Carroll C.	2018
22	Delayed Recanalization Promotes Functional Recovery in Rats Following Permanent Middle Cerebral Artery Occlusion. ( 29354887 )	McBride D.W....Zhang J.H.	2018
23	Ginkgolide K promotes angiogenesis in a middle cerebral artery occlusion mouse model via activating JAK2/STAT3 pathway. ( 29890157 )	Chen M....Hu G.	2018
24	Effect of laser Doppler flowmetry and occlusion time on outcome variability and mortality in rat middle cerebral artery occlusion: inconclusive results. ( 29673328 )	Ingberg E....StrAPm J.O.	2018
25	Intravenously Delivered Allogeneic Mesenchymal Stem Cells Bidirectionally Regulate Inflammation and Induce Neurotrophic Effects in Distal Middle Cerebral Artery Occlusion Rats Within the First 7 Days After Stroke. ( 29719282 )	Li X....Zhang Y.A.	2018
26	Neuronal loss and gliosis in the rat striatum subjected to 15 and 30 minutes of middle cerebral artery occlusion. ( 29354885 )	Park J.H....Kang I.J.	2018
27	The degree of leukoaraiosis predicts clinical outcomes and prognosis in patients with middle cerebral artery occlusion after intravenous thrombolysis. ( 29288062 )	Liu Y....Zhou X.	2018
28	Epigallocatechin-3-Gallate Reduces Neuronal Apoptosis in Rats after Middle Cerebral Artery Occlusion Injury via PI3K/AKT/eNOS Signaling Pathway. ( 29770336 )	Nan W....Zhongxin X.	2018
29	Ischemic Stroke Detection by Analyzing Heart Rate Variability in Rat Middle Cerebral Artery Occlusion Model. ( 29877839 )	Kodama T....Murayama Y.	2018
30	MicroRNA-149-5p regulates blood-brain barrier permeability after transient middle cerebral artery occlusion in rats by targeting S1PR2 of pericytes. ( 29401609 )	Wan Y....Hu B.	2018
31	Hypoxic postconditioning enhances functional recovery following endothelin-1 induced middle cerebral artery occlusion in conscious rats. ( 29778441 )	Nguyen H.L....Jones N.M.	2018
32	Licorice Pretreatment Protects Against Brain Damage Induced by Middle Cerebral Artery Occlusion in Mice. ( 29341803 )	Lim C....Cho S.	2018
33	Electroacupuncture: a new approach to open the blood-brain barrier in rats recovering from middle cerebral artery occlusion. ( 29903719 )	Zhang J....Di Z.	2018
34	Identification of Proteins Differentially Expressed by Quercetin Treatment in a Middle Cerebral Artery Occlusion Model: A Proteomics Approach. ( 29926355 )	Shah F.A....Koh P.O.	2018
35	Bilateral Middle Cerebral Artery Occlusion In Rapid Succession During Thrombolysis. ( 29623161 )	Braksick S.A....Wijdicks E.F.M.	2018
36	Long non-coding RNA RMST silencing protects against middle cerebral artery occlusion (MCAO)-induced ischemic stroke. ( 29258823 )	Hou X.X....Cheng H.	2018
37	Citalopram attenuated neurobehavioral, biochemical, and metabolic alterations in transient middle cerebral artery occlusion model of stroke in male Wistar rats. ( 29656429 )	Gupta S....Gupta Y.K.	2018
38	Evidence from functional ultrasound imaging of enhanced contralesional microvascular response to somatosensory stimulation in acute middle cerebral artery occlusion/reperfusion in rats: A marker of ultra-early network reorganization? ( 29972329 )	Brunner C....Baron J.C.	2018
39	Comparison of therapeutic efficacy between isolated encephaloduroarteriosynangiosis and medical treatment in patients with atherosclerotic middle cerebral artery occlusion. ( 29935318 )	Zhang Q....Yu S.	2018
40	Tirofiban combined with rt-PA intraarterial thrombolysis improves the recanalization rate of acute middle cerebral artery occlusion in rabbits. ( 29771445 )	Yu Y.J....Xiong W.	2018
41	Dipyridamole plus Triflusal versus Triflusal Alone in Infarct Reduction after Middle Cerebral Artery Occlusion. ( 29338983 )	Amtul Z....Cechetto D.F.	2018
42	Tail Vein Infusion of Adipose-Derived Mesenchymal Stem Cell Alleviated Inflammatory Response and Improved Blood Brain Barrier Condition by Suppressing Endoplasmic Reticulum Stress in a Middle Cerebral Artery Occlusion Rat Model. ( 29888735 )	Chi L....Nan G.	2018
43	Mechanical Thrombectomy of Acute Middle Cerebral Artery Occlusion using Trans-Anterior Communicating Artery Approach. ( 29339323 )	Amuluru K....Al-Mufti F.	2018
44	Protective effects of beef decoction rich in carnosine on cerebral ischemia injury by permanent middle cerebral artery occlusion in rats. ( 29399121 )	Wang A.H....Xu G.H.	2018
45	Targeted Temperature Management at 33A^C or 36A^C Produces Equivalent Neuroprotective Effects in the Middle Cerebral Artery Occlusion Rat Model of Ischemic Stroke. ( 29337840 )	Lee J.H....You J.S.	2018
46	Repeated Endovascular Treatment of Early Recurrent Proximal Middle Cerebral Artery Occlusion: Case Report and Brief Review of the Literature. ( 29774008 )	Fandler S....Gattringer T.	2018
47	Predictors of short-term outcome in patients with acute middle cerebral artery occlusion: unsuitability of fluid-attenuated inversion recovery vascular hyperintensity scores. ( 29451209 )	Li C.C....Yang Y.M.	2018
48	Ischemia Reperfusion Injury after Gradual versus Rapid Flow Restoration for Middle Cerebral Artery Occlusion Rats. ( 29374244 )	Xu W.W....Jiang W.J.	2018
49	Myricetin against ischemic cerebral injury in rat middle cerebral artery occlusion model. ( 29257250 )	Sun L....Han J.	2018
50	Characterization of the transient middle cerebral artery occlusion model of ischemic stroke in a HuR transgenic mouse line. ( 29854897 )	Ardelt A....King P.	2018

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Genes for Cerebral Artery Occlusion

Genes related to Cerebral Artery Occlusion (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	20.06	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	GDNF	Glial Cell Derived Neurotrophic Factor	Protein Coding	19.86	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	ODC1	Ornithine Decarboxylase 1	Protein Coding	17.24	GeneCards inferred via : Publications (show sections)
4	NOS3	Nitric Oxide Synthase 3	Protein Coding	16.9	GeneCards inferred via : Publications (show sections)
5	APOE	Apolipoprotein E	Protein Coding	16.9	GeneCards inferred via : Publications (show sections)
6	IL16	Interleukin 16	Protein Coding	16.9	GeneCards inferred via : Publications (show sections)
7	CNTF	Ciliary Neurotrophic Factor	Protein Coding	16.9	GeneCards inferred via : Publications (show sections)
8	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	16.9	GeneCards inferred via : Publications (show sections)
9	NOS1	Nitric Oxide Synthase 1	Protein Coding	16.9	GeneCards inferred via : Publications (show sections)

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Variations for Cerebral Artery Occlusion

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Expression for Cerebral Artery Occlusion

Search GEO for disease gene expression data for Cerebral Artery Occlusion.

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Pathways for Cerebral Artery Occlusion

Pathways related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 25)

#	Super pathways	Score	Top Affiliating Genes
1	PEDF Induced Signaling ⁶⁵ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁵ Cytokine-cytokine receptor interaction ³⁸ Endothelin-1 Signaling Pathway ⁶⁵ Glucocorticoid Receptor Signaling ⁶⁵ IL-6 Pathway ⁶⁵ MIF Mediated Glucocorticoid Regulation ⁶⁵ MIF Regulation of Innate Immune Cells ⁶⁵ NFAT Signaling and Lymphocyte Interactions ⁶⁵ PGC1Alpha Pathway ⁶⁵ RAR-Gamma-RXR-Alpha Degradation ⁶⁵ STAT3 Pathway ⁶⁵	13.04	BDNF CNTF GDNF IL16 MAPK1 NOS1
2	G-Beta Gamma Signaling ⁶⁵ Show member pathways CRHR Pathway ⁶⁵ Gap junction ³⁸ GHRH Signaling ⁶⁵ Hedgehog Signaling in Mammals ⁶⁵ Relaxin Pathway ⁶⁵ Signaling in Gap Junctions ⁶⁵	12.79	BDNF MAPK1 NOS1 NOS3
3	Immune response IL-23 signaling pathway ²³ Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶⁵ Development Angiopoietin - Tie2 signaling ²³ Development PDGF signaling via STATs and NF-kB ²³ IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²³ Rac1/Pak1/p38/MMP-2 pathway ¹	12.33	MAPK1 NOS1 NOS3
4	GDNF-Family Ligands and Receptor Interactions ⁶⁵ Show member pathways BDNF Pathway ⁶⁵ Development GDNF family signaling ²³	11.86	BDNF GDNF MAPK1
5	Apelin signaling pathway ³⁸	11.75	MAPK1 NOS1 NOS3
6	Apoptosis-related network due to altered Notch3 in ovarian cancer ¹	11.35	APOE MAPK1
7	HIF1Alpha Pathway ⁶⁵	11.34	MAPK1 NOS3
8	Neural Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁶	11.33	BDNF CNTF GDNF
9	Alzheimers Disease Pathway ⁶⁵	11.26	APOE MAPK1
10	Nitric oxide stimulates guanylate cyclase ⁶⁷ Show member pathways cGMP effects ⁶⁷	11.22	NOS1 NOS3
11	Doxorubicin Pathway, Pharmacokinetics ⁶² Show member pathways Doxorubicin Pathway (Cancer Cell), Pharmacodynamics ⁶²	11.19	NOS1 NOS3
12	Signaling events regulated by Ret tyrosine kinase ¹	11.16	GDNF MAPK1
13	BDNF-TrkB Signaling ¹	11.1	BDNF MAPK1
14	Endothelin Pathways ¹	11.09	MAPK1 NOS3
15	Spinal Cord Injury ¹	11	BDNF GDNF MAPK1 NOS1
16	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2 ²³	10.99	MAPK1 NOS1
17	Ibuprofen Pathway, Pharmacodynamics ⁶²	10.98	NOS1 NOS3
18	Follicle Stimulating Hormone (FSH) signaling pathway ¹	10.96	BDNF MAPK1
19	Arginine biosynthesis ³⁸ Show member pathways citrulline-nitric oxide cycle ¹	10.93	NOS1 NOS3
20	Arginine and proline metabolism ³⁸ Show member pathways 4-hydroxyproline degradation ¹ Agmatine biosynthesis ⁶⁷ putrescine biosynthesis II ¹	10.89	NOS1 NOS3 ODC1
21	Angiogenesis (WikiPathways) ¹	10.87	MAPK1 NOS3
22	Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics ⁶²	10.86	NOS1 NOS3
23	ERK Pathway in Huntingtons Disease ¹	10.55	BDNF MAPK1
24	NO-dependent CFTR activation (normal and CF) ²³	10.48	NOS1 NOS3
25	Effects of Nitric Oxide ¹	10.22	NOS1 NOS3

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GO Terms for Cerebral Artery Occlusion

Cellular components related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:0005737	9.86	APOE BDNF CNTF IL16 MAPK1 NOS1
2	extracellular region	GO:0005576	9.43	APOE BDNF CNTF GDNF IL16 MAPK1
3	vesicle membrane	GO:0012506	9.16	NOS1 NOS3
4	caveola	GO:0005901	8.8	MAPK1 NOS1 NOS3

Biological processes related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 20)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:0008284	9.84	CNTF GDNF MAPK1 ODC1
2	regulation of signaling receptor activity	GO:0010469	9.8	BDNF CNTF GDNF IL16
3	regulation of gene expression	GO:0010468	9.75	APOE GDNF MAPK1
4	axon guidance	GO:0007411	9.72	BDNF GDNF MAPK1
5	response to lipopolysaccharide	GO:0032496	9.7	MAPK1 NOS1 NOS3
6	response to heat	GO:0009408	9.59	NOS1 NOS3
7	lipopolysaccharide-mediated signaling pathway	GO:0031663	9.58	MAPK1 NOS3
8	negative regulation of blood pressure	GO:0045776	9.57	NOS1 NOS3
9	peripheral nervous system development	GO:0007422	9.56	BDNF GDNF
10	regulation of sodium ion transport	GO:0002028	9.51	NOS1 NOS3
11	negative regulation of calcium ion transport	GO:0051926	9.48	NOS1 NOS3
12	nitric oxide biosynthetic process	GO:0006809	9.46	NOS1 NOS3
13	negative regulation of neuron apoptotic process	GO:0043524	9.46	APOE BDNF CNTF GDNF
14	negative regulation of potassium ion transport	GO:0043267	9.43	NOS1 NOS3
15	positive regulation of guanylate cyclase activity	GO:0031284	9.4	NOS1 NOS3
16	negative regulation of platelet activation	GO:0010544	9.37	APOE NOS3
17	arginine catabolic process	GO:0006527	9.32	NOS1 NOS3
18	negative regulation of hydrolase activity	GO:0051346	9.26	NOS1 NOS3
19	vasodilation	GO:0042311	9.13	APOE NOS1 NOS3
20	nitric oxide mediated signal transduction	GO:0007263	8.8	APOE NOS1 NOS3

Molecular functions related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:0008083	9.58	BDNF CNTF GDNF
2	NADP binding	GO:0050661	9.43	NOS1 NOS3
3	FMN binding	GO:0010181	9.37	NOS1 NOS3
4	arginine binding	GO:0034618	9.32	NOS1 NOS3
5	NADPH-hemoprotein reductase activity	GO:0003958	9.26	NOS1 NOS3
6	cadmium ion binding	GO:0046870	9.16	NOS1 NOS3
7	tetrahydrobiopterin binding	GO:0034617	8.96	NOS1 NOS3
8	nitric-oxide synthase activity	GO:0004517	8.62	NOS1 NOS3

Sources

Sources for Cerebral Artery Occlusion

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

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²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

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³¹ HGMD

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³⁵ ICD10 via Orphanet

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⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia