Cerebral Artery Occlusion disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CRB004 MIFTS: 45	Cerebral Artery Occlusion Categories: Cardiovascular diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Cerebral Artery Occlusion

MalaCards integrated aliases for Cerebral Artery Occlusion:

Name: Cerebral Artery Occlusion ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:10127

ICD9CM ³⁵ 434 434.9

SNOMED-CT ⁶⁸ 20059004

UMLS ⁷³ C0028790

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Summaries for Cerebral Artery Occlusion

MalaCards based summary : Cerebral Artery Occlusion is related to brain injury and dementia. An important gene associated with Cerebral Artery Occlusion is BDNF (Brain Derived Neurotrophic Factor), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. The drugs Abciximab and Tissue Plasminogen Activator have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and endothelial, and related phenotypes are Increased LDL uptake and cellular

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Related Diseases for Cerebral Artery Occlusion

Diseases related to Cerebral Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)

#	Related Disease	Score	Top Affiliating Genes
1	brain injury	30.7	BDNF APOE
2	dementia	29.5	TNF BDNF APOE
3	ischemia	10.7
4	brain edema	10.4
5	stroke, ischemic	10.3
6	hypoxia	10.2
7	brain ischemia	10.2
8	jejunoileitis	10.1	TNF GDNF
9	idiopathic achalasia	10.1	TNF NOS2
10	dystrophinopathies	10.1	TNF NOS2
11	crohn's colitis	10.1	TNF NOS2
12	vertebral artery occlusion	10.1	NOS2 BDNF
13	arthus reaction	10.1	TNF NOS2
14	drug-induced hearing loss	10.1	GDNF BDNF
15	eales disease	10.1	TNF NOS2
16	brachial plexus lesion	10.1	GDNF BDNF
17	spinal cord disease	10.1	TNF GDNF
18	traumatic brain injury	10.1	BDNF APOE
19	ischemic heart disease	10.1	TNF APOE
20	mutism	10.1
21	hyperglycemia	10.1
22	akinetic mutism	10.1
23	carotid artery dissection	10.1
24	pyosalpinx	10.1	NOS2 APOE
25	bacterial sepsis	10.0	TNF NOS2
26	sleeping sickness	10.0	ODC1 NOS2
27	hepatopulmonary syndrome	10.0	TNF NOS2
28	inclusion conjunctivitis	10.0	TNF IL16
29	cerebral hemorrhage	10.0
30	hemiplegia	10.0
31	depression	10.0
32	carotid stenosis	10.0	TNF APOE
33	louse-borne relapsing fever	10.0	TNF MAPK1
34	major depressive disorder	10.0	TNF BDNF APOE
35	aphasia	9.9	BDNF APOE
36	atrophic gastritis	9.9	TNF ODC1
37	moyamoya disease 1	9.9
38	neonatal stroke	9.9
39	infective endocarditis	9.9
40	endocarditis	9.9
41	cerebral hypoxia	9.9
42	dermatitis, atopic	9.9	TNF IL16 BDNF
43	acute vascular insufficiency of intestine	9.8	TNF MAPK1 GDNF
44	central nervous system disease	9.8	TNF NOS2 BDNF APOE
45	multiple sclerosis	9.8	TNF NOS2 BDNF APOE
46	cerebral amyloid angiopathy, cst3-related	9.8
47	arteries, anomalies of	9.8
48	temporal arteritis	9.8
49	neutrophil actin dysfunction	9.8
50	aging	9.8

Graphical network of the top 20 diseases related to Cerebral Artery Occlusion:

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Symptoms & Phenotypes for Cerebral Artery Occlusion

GenomeRNAi Phenotypes related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased LDL uptake	GR00340-A-1	8.62	APOE SORT1

MGI Mouse Phenotypes related to Cerebral Artery Occlusion:

⁴⁶ (show all 13)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.11	APOE BDNF GDNF MAPK1 NOS2 ODC1
2	mortality/aging	MP:0010768	10.01	APOE BDNF GDNF MAPK1 NOS2 ODC1
3	cardiovascular system	MP:0005385	10	APOE GDNF MAPK1 NOS2 SORT1 TNF
4	growth/size/body region	MP:0005378	10	APOE BDNF GDNF MAPK1 NOS2 ODC1
5	immune system	MP:0005387	9.98	APOE GDNF IL16 MAPK1 NOS2 SORT1
6	digestive/alimentary	MP:0005381	9.97	APOE BDNF GDNF MAPK1 NOS2 TNF
7	endocrine/exocrine gland	MP:0005379	9.95	APOE BDNF GDNF MAPK1 NOS2 TNF
8	nervous system	MP:0003631	9.87	APOE BDNF GDNF MAPK1 NOS2 SORT1
9	muscle	MP:0005369	9.85	APOE GDNF MAPK1 NOS2 SORT1 TNF
10	reproductive system	MP:0005389	9.73	APOE BDNF GDNF MAPK1 NOS2 TNF
11	respiratory system	MP:0005388	9.55	APOE BDNF MAPK1 NOS2 TNF
12	taste/olfaction	MP:0005394	9.13	APOE BDNF MAPK1
13	vision/eye	MP:0005391	9.1	APOE BDNF MAPK1 NOS2 SORT1 TNF

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Drugs & Therapeutics for Cerebral Artery Occlusion

Drugs for Cerebral Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Abciximab

Approved

Phase 4

143653-53-6

Tissue Plasminogen Activator

Phase 4,Phase 3,Phase 2,Not Applicable

Fibrinolytic Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Platelet Aggregation Inhibitors

Phase 4,Phase 3,Phase 2

Plasminogen

Phase 4,Phase 2,Not Applicable

Anticoagulants

Phase 4,Phase 2

Mitogens

Phase 4

Antibodies

Phase 4

Immunoglobulins

Phase 4

Immunoglobulin Fab Fragments

Phase 4

Antibodies, Monoclonal

Phase 4

Immunologic Factors

Phase 4

Clopidogrel

Approved

Phase 3

113665-84-2, 120202-66-6

60606

Aspirin

Approved, Vet_approved

Phase 3

50-78-2

2244

Ticlopidine

Approved

Phase 3

55142-85-3

5472

Analgesics, Non-Narcotic

Phase 3

Purinergic P2Y Receptor Antagonists

Phase 3

Analgesics

Phase 3

Cytochrome P-450 Enzyme Inhibitors

Phase 3

Peripheral Nervous System Agents

Phase 3

Cytochrome P-450 CYP2C19 Inhibitors

Phase 3

Anti-Inflammatory Agents, Non-Steroidal

Phase 3

Purinergic P2 Receptor Antagonists

Phase 3

Antirheumatic Agents

Phase 3

Cyclooxygenase Inhibitors

Phase 3

Neurotransmitter Agents

Phase 3

Antipyretics

Phase 3

Anti-Inflammatory Agents

Phase 3

Iron

Approved

Phase 2

7439-89-6

23925

Deferoxamine

Approved, Investigational

Phase 2

70-51-9

2973

Argatroban

Approved, Investigational

Phase 2

74863-84-6

152951

Serine

Approved, Nutraceutical

Phase 2

56-45-1

5951

Pharmaceutical Solutions

Phase 2

Iron Chelating Agents

Phase 2

Chelating Agents

Phase 2

Antithrombin III

Phase 2

protease inhibitors

Phase 2

HIV Protease Inhibitors

Phase 2

Antithrombins

Phase 2

Serine Proteinase Inhibitors

Phase 2

Warfarin

Approved

81-81-2

6691 54678486

Dabigatran

Interventional clinical trials:

(show all 13)

#	Name	Status	NCT ID	Phase	Drugs
1	A Randomized Double Blind Placebo Control Study of Huang-Chi-Wu-Wu- Tang in Patients With Intracranial Arterial Stenosis	Unknown status	NCT01553643	Phase 4	Chinese Herb Huang-Chi-Wu-Wu-Tang;placebo
2	Effects of Intranasal Nerve Growth Factor for Acute Ischemic Stroke	Recruiting	NCT03686163	Phase 4	Nerve Growth Factors;normal saline
3	Thrombectomy Under Reopro Versus Alteplase to Treat Stoke	Terminated	NCT02016547	Phase 4	alteplase 0.9mg/kg (10% by IV bolus following by 90% by 1 hour IV drip)
4	The Carotid and Middle Cerebral Artery Occlusion Surgery Study	Unknown status	NCT01758614	Phase 3	Aspirin;Clopidogrel
5	Ultrasound Enhanced Thrombolytic Therapy of Middle Cerebral Artery Occlusion	Unknown status	NCT00336596	Phase 3
6	Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion	Completed	NCT00777140	Phase 2	Deferoxamine
7	Safety and Feasibility of Argatroban, Tissue Plasminogen Activator and Intra-arterial Therapy in Stroke	Completed	NCT02448069	Phase 2	Argatroban
8	Superiority of Rt-PA + Tenecteplase in Comparison With Rt-PA Only in Proximal Middle Cerebral Artery Occlusion	Withdrawn	NCT02338466	Phase 2	rt-PA;tenecteplase
9	Use of Hypothermia During Robotic Prostatectomy	Unknown status	NCT00915031	Not Applicable
10	Neurothrombectomy France	Completed	NCT02880579
11	The Comparative Safety and Effectiveness of Warfarin and Dabigatran Prescribed in the Non-valvular Atrial Fibrillation Population With Humana Healthcare Coverage	Completed	NCT02061748		Observational
12	Berlin PRehospital Or Usual Delivery of Acute Stroke Care	Recruiting	NCT02869386	Not Applicable
13	Embolectomy in Acute SYlvian Thrombosis in Refractory or Ineligible Patients to ALteplase	Terminated	NCT02216565	Not Applicable	Alteplase if patient is eligible

Search NIH Clinical Center for Cerebral Artery Occlusion

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Genetic Tests for Cerebral Artery Occlusion

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Anatomical Context for Cerebral Artery Occlusion

MalaCards organs/tissues related to Cerebral Artery Occlusion:

⁴¹

Brain, Bone, Endothelial, Cortex, Bone Marrow, Heart, Spinal Cord

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Publications for Cerebral Artery Occlusion

Articles related to Cerebral Artery Occlusion:

(show top 50) (show all 1035)

#	Title	Authors	Year
1	'Governor vessel-unblocking and mind-regulating' acupuncture therapy ameliorates cognitive dysfunction in a rat model of middle cerebral artery occlusion. ( 30431067 )	Su X...Zhu J	2019
2	An enriched environment promotes synaptic plasticity and cognitive recovery after permanent middle cerebral artery occlusion in mice. ( 30539814 )	Wang CJ...Wang YY	2019
3	Using the behavioral flexibility operant task to detect long-term deficits in rats following middle cerebral artery occlusion. ( 30107224 )	Andrews MMM...Dunbar GL	2019
4	Progression of vasogenic edema induced by activated microglia under permanent middle cerebral artery occlusion. ( 29353043 )	Tanaka M....Itoh K.	2018
5	Middle Cerebral Artery Occlusion by an Intraluminal Suture Method. ( 29222799 )	Crupi R....Cuzzocrea S.	2018
6	Dietary nitrate supplementation reduces low frequency blood pressure fluctuations in rats following distal middle cerebral artery occlusion. ( 29856262 )	Allan P.D....Fan J.L.	2018
7	Acute Right Middle Cerebral Artery Occlusion Resulting in Acute Systolic Heart Failure, Cerebral T-Waves, and QTc Prolongation: A Case Report. ( 29953038 )	Blech B....O'Carroll C.	2018
8	Delayed Recanalization Promotes Functional Recovery in Rats Following Permanent Middle Cerebral Artery Occlusion. ( 29354887 )	McBride D.W....Zhang J.H.	2018
9	Ginkgolide K promotes angiogenesis in a middle cerebral artery occlusion mouse model via activating JAK2/STAT3 pathway. ( 29890157 )	Chen M....Hu G.	2018
10	Effect of laser Doppler flowmetry and occlusion time on outcome variability and mortality in rat middle cerebral artery occlusion: inconclusive results. ( 29673328 )	Ingberg E....StrAPm J.O.	2018
11	Intravenously Delivered Allogeneic Mesenchymal Stem Cells Bidirectionally Regulate Inflammation and Induce Neurotrophic Effects in Distal Middle Cerebral Artery Occlusion Rats Within the First 7 Days After Stroke. ( 29719282 )	Li X....Zhang Y.A.	2018
12	Neuronal loss and gliosis in the rat striatum subjected to 15 and 30 minutes of middle cerebral artery occlusion. ( 29354885 )	Park J.H....Kang I.J.	2018
13	The degree of leukoaraiosis predicts clinical outcomes and prognosis in patients with middle cerebral artery occlusion after intravenous thrombolysis. ( 29288062 )	Liu Y....Zhou X.	2018
14	Epigallocatechin-3-Gallate Reduces Neuronal Apoptosis in Rats after Middle Cerebral Artery Occlusion Injury via PI3K/AKT/eNOS Signaling Pathway. ( 29770336 )	Nan W....Zhongxin X.	2018
15	Ischemic Stroke Detection by Analyzing Heart Rate Variability in Rat Middle Cerebral Artery Occlusion Model. ( 29877839 )	Kodama T....Murayama Y.	2018
16	MicroRNA-149-5p regulates blood-brain barrier permeability after transient middle cerebral artery occlusion in rats by targeting S1PR2 of pericytes. ( 29401609 )	Wan Y....Hu B.	2018
17	Hypoxic postconditioning enhances functional recovery following endothelin-1 induced middle cerebral artery occlusion in conscious rats. ( 29778441 )	Nguyen H.L....Jones N.M.	2018
18	Licorice Pretreatment Protects Against Brain Damage Induced by Middle Cerebral Artery Occlusion in Mice. ( 29341803 )	Lim C....Cho S.	2018
19	Electroacupuncture: a new approach to open the blood-brain barrier in rats recovering from middle cerebral artery occlusion. ( 29903719 )	Zhang J....Di Z.	2018
20	Identification of Proteins Differentially Expressed by Quercetin Treatment in a Middle Cerebral Artery Occlusion Model: A Proteomics Approach. ( 29926355 )		2018
21	Bilateral Middle Cerebral Artery Occlusion In Rapid Succession During Thrombolysis. ( 29623161 )		2018
22	Long non-coding RNA RMST silencing protects against middle cerebral artery occlusion (MCAO)-induced ischemic stroke. ( 29258823 )		2018
23	Citalopram attenuated neurobehavioral, biochemical, and metabolic alterations in transient middle cerebral artery occlusion model of stroke in male Wistar rats. ( 29656429 )		2018
24	Evidence from functional ultrasound imaging of enhanced contralesional microvascular response to somatosensory stimulation in acute middle cerebral artery occlusion/reperfusion in rats: A marker of ultra-early network reorganization? ( 29972329 )		2018
25	Comparison of therapeutic efficacy between isolated encephaloduroarteriosynangiosis and medical treatment in patients with atherosclerotic middle cerebral artery occlusion. ( 29935318 )		2018
26	Tirofiban combined with rt-PA intraarterial thrombolysis improves the recanalization rate of acute middle cerebral artery occlusion in rabbits. ( 29771445 )		2018
27	Dipyridamole plus Triflusal versus Triflusal Alone in Infarct Reduction after Middle Cerebral Artery Occlusion. ( 29338983 )		2018
28	Tail Vein Infusion of Adipose-Derived Mesenchymal Stem Cell Alleviated Inflammatory Response and Improved Blood Brain Barrier Condition by Suppressing Endoplasmic Reticulum Stress in a Middle Cerebral Artery Occlusion Rat Model. ( 29888735 )		2018
29	Mechanical Thrombectomy of Acute Middle Cerebral Artery Occlusion using Trans-Anterior Communicating Artery Approach. ( 29339323 )		2018
30	Protective effects of beef decoction rich in carnosine on cerebral ischemia injury by permanent middle cerebral artery occlusion in rats. ( 29399121 )		2018
31	Targeted Temperature Management at 33A^C or 36A^C Produces Equivalent Neuroprotective Effects in the Middle Cerebral Artery Occlusion Rat Model of Ischemic Stroke. ( 29337840 )		2018
32	Repeated Endovascular Treatment of Early Recurrent Proximal Middle Cerebral Artery Occlusion: Case Report and Brief Review of the Literature. ( 29774008 )		2018
33	Predictors of short-term outcome in patients with acute middle cerebral artery occlusion: unsuitability of fluid-attenuated inversion recovery vascular hyperintensity scores. ( 29451209 )		2018
34	Ischemia Reperfusion Injury after Gradual versus Rapid Flow Restoration for Middle Cerebral Artery Occlusion Rats. ( 29374244 )		2018
35	Myricetin against ischemic cerebral injury in rat middle cerebral artery occlusion model. ( 29257250 )		2018
36	Netrin-1 attenuates brain injury after middle cerebral artery occlusion via downregulation of astrocyte activation in mice. ( 30227858 )	He X...Yang GY	2018
37	Fluctuations of Nutrition-Associated Markers After Decompressive Hemicraniectomy in Middle Cerebral Artery Occlusion Patients. ( 30178320 )	Kutsuna N...Kagawa Y	2018
38	Mechanical Thrombectomy for Acute Anterior Cerebral Artery Occlusion. ( 30189299 )	Uno J...Gi H	2018
39	Effect of Ginkgo biloba extract-761 on motor functions in permanent middle cerebral artery occlusion rats. ( 30195885 )	Zeng GR...Liu XM	2018
40	Oncostatin M-induced upregulation of SDF-1 improves Bone marrow stromal cell migration in a rat middle cerebral artery occlusion stroke model. ( 30213507 )	Han J...Jiang X	2018
41	Crotalus atrox disintegrin reduces hemorrhagic transformation by attenuating matrix metalloproteinase-9 activity after middle cerebral artery occlusion in hyperglycemic male rats. ( 30242872 )	McBride DW...Zhang JH	2018
42	Survivin overexpression via adeno-associated virus vector Rh10 ameliorates ischemic damage after middle cerebral artery occlusion in rats. ( 30251448 )	Sehara Y...Mizukami H	2018
43	Transradial Mechanical Thrombectomy for Proximal Middle Cerebral Artery Occlusion in a First Trimester Pregnancy: Case Report and Literature Review. ( 30261390 )	Shah SS...Peterson EC	2018
44	Celecoxib Treatment Improves Neurologic Deficit and Reduces Selective Neuronal Loss and Glial Response in Rats after Transient Middle Cerebral Artery Occlusion. ( 30291174 )	Santos-Galdiano M...Fern?ndez-L?pez A	2018
45	Effects of Dehydration on Brain Perfusion and Infarct Core After Acute Middle Cerebral Artery Occlusion in Rats: Evidence From High-Field Magnetic Resonance Imaging. ( 30294297 )	Tsai YH...Su CH	2018
46	Diabetes mellitus inhibits complete recanalization in patients with middle cerebral artery occlusion. ( 30319049 )	Aoki J...YAMATO study investigators	2018
47	Right Insular Cortex Ischemia Caused by Middle Cerebral Artery Occlusion: A Possible Pathogenesis of Decreased Sympathetic Nervous System Activity? ( 30379744 )	Nagai M...Dote K	2018
48	Implications of Mechanical Endovascular Thrombectomy for Acute Basilar and Posterior Cerebral Artery Occlusion. ( 30397588 )	Lee HN...Shin DS	2018
49	MicroRNA-122 Mimic Improves Stroke Outcomes and Indirectly Inhibits NOS2 After Middle Cerebral Artery Occlusion in Rats. ( 30405345 )	Lv B...Liu DZ	2018
50	Neuroprotective Effect of IRL-1620, an Endothelin B Receptor Agonist, on a Pediatric Rat Model of Middle Cerebral Artery Occlusion. ( 30406063 )	Cifuentes EG...Gulati A	2018

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Genes for Cerebral Artery Occlusion

Genes related to Cerebral Artery Occlusion (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	20.09	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	TNF	Tumor Necrosis Factor	Protein Coding	19.86	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	GDNF	Glial Cell Derived Neurotrophic Factor	Protein Coding	19.86	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	ODC1	Ornithine Decarboxylase 1	Protein Coding	17.24	GeneCards inferred via : Publications (show sections)
5	NOS2	Nitric Oxide Synthase 2	Protein Coding	16.89	GeneCards inferred via : Publications (show sections)
6	APOE	Apolipoprotein E	Protein Coding	16.89	GeneCards inferred via : Publications (show sections)
7	IL16	Interleukin 16	Protein Coding	16.89	GeneCards inferred via : Publications (show sections)
8	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	16.89	GeneCards inferred via : Publications (show sections)
9	SORT1	Sortilin 1	Protein Coding	16.89	GeneCards inferred via : Publications (show sections)

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Variations for Cerebral Artery Occlusion

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Expression for Cerebral Artery Occlusion

Search GEO for disease gene expression data for Cerebral Artery Occlusion.

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Pathways for Cerebral Artery Occlusion

Pathways related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 26)

#	Super pathways	Score	Top Affiliating Genes
1	PEDF Induced Signaling ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Cytokine-cytokine receptor interaction ³⁷ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Mediated Glucocorticoid Regulation ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.33	BDNF GDNF IL16 MAPK1 NOS2 TNF
2	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.08	GDNF IL16 MAPK1 NOS2 TNF
3	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.06	MAPK1 NOS2 TNF
4	Toxoplasmosis ³⁷ Show member pathways Leishmaniasis ³⁷	12	MAPK1 NOS2 TNF
5	Tuberculosis ³⁷	11.97	MAPK1 NOS2 TNF
6	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways Immune response IL-1 signaling pathway ²² Mucin expression in CF via TLRs, EGFR signaling pathways ²²	11.92	MAPK1 NOS2 TNF
7	GDNF-Family Ligands and Receptor Interactions ⁶⁴ Show member pathways BDNF Pathway ⁶⁴ Development GDNF family signaling ²²	11.86	BDNF GDNF MAPK1
8	Colorectal Cancer Metastasis ⁶⁴	11.83	MAPK1 NOS2 TNF
9	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway ¹	11.74	BDNF MAPK1 SORT1
10	Pertussis ³⁷	11.38	MAPK1 NOS2 TNF
11	Aryl Hydrocarbon Receptor ¹	11.31	MAPK1 TNF
12	MSP-RON Signaling ⁶⁴	11.3	NOS2 TNF
13	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁵	11.28	BDNF NOS2 TNF
14	Alzheimers Disease Pathway ⁶⁴	11.27	APOE MAPK1
15	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.26	APOE TNF
16	Ceramide signaling pathway ¹	11.25	MAPK1 TNF
17	Signaling events regulated by Ret tyrosine kinase ¹	11.18	GDNF MAPK1
18	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.13	MAPK1 NOS2 TNF
19	BDNF-TrkB Signaling ¹	11.12	BDNF MAPK1
20	Spinal Cord Injury ¹	11.1	BDNF GDNF MAPK1 NOS2 TNF
21	Follicle Stimulating Hormone (FSH) signaling pathway ¹	11.01	BDNF MAPK1
22	EBV LMP1 signaling ¹	10.94	MAPK1 TNF
23	Cellular roles of Anthrax toxin ¹	10.87	MAPK1 TNF
24	Apoptosis-related network due to altered Notch3 in ovarian cancer ¹	10.86	APOE MAPK1 TNF
25	G-protein signaling_Rap2B regulation pathway ²²	10.68	BDNF IL16 MAPK1 TNF
26	ERK Pathway in Huntingtons Disease ¹	10.51	BDNF MAPK1

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GO Terms for Cerebral Artery Occlusion

Cellular components related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	early endosome	GO:0005769	9.33	APOE MAPK1 SORT1
2	perinuclear region of cytoplasm	GO:0048471	9.26	BDNF NOS2 ODC1 SORT1
3	extracellular region	GO:0005576	9.1	APOE BDNF GDNF IL16 MAPK1 TNF

Biological processes related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine-mediated signaling pathway	GO:0019221	9.73	IL16 NOS2 TNF
2	negative regulation of gene expression	GO:0010629	9.72	APOE NOS2 TNF
3	MAPK cascade	GO:0000165	9.65	GDNF MAPK1 TNF
4	axon guidance	GO:0007411	9.61	BDNF GDNF MAPK1
5	negative regulation of fat cell differentiation	GO:0045599	9.57	SORT1 TNF
6	negative regulation of endothelial cell proliferation	GO:0001937	9.54	APOE TNF
7	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	9.52	GDNF TNF
8	lipopolysaccharide-mediated signaling pathway	GO:0031663	9.51	MAPK1 TNF
9	extrinsic apoptotic signaling pathway via death domain receptors	GO:0008625	9.49	SORT1 TNF
10	peripheral nervous system development	GO:0007422	9.46	BDNF GDNF
11	regulation of signaling receptor activity	GO:0010469	9.46	BDNF GDNF IL16 TNF
12	negative regulation of neuron apoptotic process	GO:0043524	9.43	APOE BDNF GDNF
13	neurotrophin TRK receptor signaling pathway	GO:0048011	9.4	BDNF SORT1
14	nitric oxide mediated signal transduction	GO:0007263	9.37	APOE NOS2
15	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.32	APOE TNF
16	nerve growth factor signaling pathway	GO:0038180	8.96	BDNF SORT1
17	regulation of gene expression	GO:0010468	8.92	APOE GDNF MAPK1 SORT1

Molecular functions related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein homodimerization activity	GO:0042803	8.92	APOE GDNF NOS2 ODC1

Sources

Sources for Cerebral Artery Occlusion

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia