MCID: CRB004
MIFTS: 47

Cerebral Artery Occlusion

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Cerebral Artery Occlusion

MalaCards integrated aliases for Cerebral Artery Occlusion:

Name: Cerebral Artery Occlusion 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:10127
ICD9CM 36 434 434.9
SNOMED-CT 69 20059004
UMLS 74 C0028790

Summaries for Cerebral Artery Occlusion

MalaCards based summary : Cerebral Artery Occlusion is related to brain injury and myocardial infarction. An important gene associated with Cerebral Artery Occlusion is BDNF (Brain Derived Neurotrophic Factor), and among its related pathways/superpathways are G-Beta Gamma Signaling and Development HGF signaling pathway. The drugs Abciximab and Fibrinolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spinal cord, and related phenotypes are Increased viability and Increased LDL uptake

Related Diseases for Cerebral Artery Occlusion

Diseases related to Cerebral Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 brain injury 31.0 APOE BDNF
2 myocardial infarction 29.0 APOE NOS3 PTGS2 SORT1
3 ischemia 10.8
4 stroke, ischemic 10.5
5 brain edema 10.5
6 hypoxia 10.3
7 hyperglycemia 10.2
8 intracranial vasospasm 10.2 APOE NOS3
9 traumatic brain injury 10.2 APOE BDNF
10 brain ischemia 10.2
11 depression 10.2
12 ischemic heart disease 10.2 APOE NOS3
13 alzheimer disease 2 10.2 APOE NOS3
14 intestinal benign neoplasm 10.1 ODC1 PTGS2
15 hemiplegia 10.1
16 aphasia 10.1 APOE BDNF
17 mutism 10.1
18 akinetic mutism 10.1
19 carotid artery dissection 10.1
20 cerebral hypoxia 10.1
21 moyamoya disease 1 10.0
22 cerebral hemorrhage 10.0
23 endocarditis 10.0
24 atrophic gastritis 10.0 IL1RN ODC1
25 colorectal adenoma 10.0 ODC1 PTGS2
26 platelet membrane fluidity 10.0 NOS2 NOS3
27 vertebral artery occlusion 10.0 BDNF NOS2
28 gastric ulcer 10.0 IL1RN PTGS2
29 peptic ulcer disease 9.9 IL1RN PTGS2
30 insulin-like growth factor i 9.9
31 hemorrhage, intracerebral 9.9
32 neonatal stroke 9.9
33 infective endocarditis 9.9
34 thrombosis 9.9
35 pertussis 9.9
36 hypoglycemia 9.9
37 hepatopulmonary syndrome 9.9 NOS2 NOS3
38 sleeping sickness 9.9 NOS2 ODC1
39 varicocele 9.9 NOS2 NOS3
40 spinal cord injury 9.8 BDNF NOS2
41 cerebral amyloid angiopathy, cst3-related 9.8
42 arteries, anomalies of 9.8
43 glioma susceptibility 1 9.8
44 pityriasis rubra pilaris 9.8
45 retinoblastoma 9.8
46 neutrophil actin dysfunction 9.8
47 retinitis pigmentosa 9.8
48 sjogren syndrome 9.8
49 aging 9.8
50 leber congenital amaurosis 4 9.8

Graphical network of the top 20 diseases related to Cerebral Artery Occlusion:



Diseases related to Cerebral Artery Occlusion

Symptoms & Phenotypes for Cerebral Artery Occlusion

GenomeRNAi Phenotypes related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability GR00386-A-1 9.17 APOE IL1RN NOS2 NOS3 ODC1 PTGS2
2 Increased LDL uptake GR00340-A-1 8.96 APOE SORT1

MGI Mouse Phenotypes related to Cerebral Artery Occlusion:

47 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.14 APOE BDNF IL1RN NOS2 NOS3 ODC1
2 growth/size/body region MP:0005378 10.11 APOE BDNF HYAL2 IL1RN NOS2 NOS3
3 homeostasis/metabolism MP:0005376 10.1 APOE BDNF HYAL2 IL1RN NOS2 NOS3
4 mortality/aging MP:0010768 10.06 APOE BDNF HYAL2 IL1RN NOS2 NOS3
5 cardiovascular system MP:0005385 10.02 APOE IL1RN NOS2 NOS3 PTGS2 SORT1
6 immune system MP:0005387 10.02 APOE HYAL2 IL1RN NOS2 NOS3 PTGS2
7 digestive/alimentary MP:0005381 9.92 APOE BDNF NOS2 NOS3 PTGS2
8 integument MP:0010771 9.85 APOE BDNF IL1RN NOS2 PTGS2
9 liver/biliary system MP:0005370 9.83 APOE HYAL2 NOS2 NOS3 PTGS2
10 muscle MP:0005369 9.77 APOE NOS2 NOS3 PTGS2 SORT1
11 reproductive system MP:0005389 9.73 APOE BDNF IL1RN NOS2 NOS3 PTGS2
12 renal/urinary system MP:0005367 9.72 APOE HYAL2 NOS2 NOS3 PTGS2
13 respiratory system MP:0005388 9.55 APOE BDNF NOS2 NOS3 PTGS2
14 skeleton MP:0005390 9.43 APOE HYAL2 IL1RN NOS2 NOS3 PTGS2
15 vision/eye MP:0005391 9.17 APOE BDNF HYAL2 NOS2 NOS3 PTGS2

Drugs & Therapeutics for Cerebral Artery Occlusion

Drugs for Cerebral Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abciximab Approved Phase 4 143653-53-6
2 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Not Applicable
3 Tissue Plasminogen Activator Phase 4,Phase 3,Phase 2,Not Applicable
4 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2
5 Plasminogen Phase 4,Phase 2,Not Applicable
6 Anticoagulants Phase 4,Phase 2
7 Mitogens Phase 4
8
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
9
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
10 Antipyretics Phase 3
11 Peripheral Nervous System Agents Phase 3
12 Purinergic P2Y Receptor Antagonists Phase 3
13 Cyclooxygenase Inhibitors Phase 3
14 Neurotransmitter Agents Phase 3
15 Anti-Inflammatory Agents Phase 3
16 Antirheumatic Agents Phase 3
17 Analgesics, Non-Narcotic Phase 3
18 Analgesics Phase 3
19 Anti-Inflammatory Agents, Non-Steroidal Phase 3
20 Purinergic P2 Receptor Antagonists Phase 3
21
Deferoxamine Approved, Investigational Phase 2 70-51-9 2973
22
Iron Approved, Experimental Phase 2 7439-89-6, 15438-31-0 27284 23925
23
Argatroban Approved, Investigational Phase 2 74863-84-6 152951
24
Serine Approved, Nutraceutical Phase 2 56-45-1 5951
25 Iron Chelating Agents Phase 2
26 Pharmaceutical Solutions Phase 2
27 Siderophores Phase 2
28 Chelating Agents Phase 2
29
protease inhibitors Phase 2
30 HIV Protease Inhibitors Phase 2
31 Antithrombin III Phase 2
32 Antithrombins Phase 2
33 Serine Proteinase Inhibitors Phase 2
34
Warfarin Approved 81-81-2 54678486 6691
35
Dabigatran Investigational 211914-51-1

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 A Randomized Double Blind Placebo Control Study of Huang-Chi-Wu-Wu- Tang in Patients With Intracranial Arterial Stenosis Unknown status NCT01553643 Phase 4 Chinese Herb Huang-Chi-Wu-Wu-Tang;placebo
2 Effects of Intranasal Nerve Growth Factor for Acute Ischemic Stroke Recruiting NCT03686163 Phase 4 Nerve Growth Factors;normal saline
3 Thrombectomy Under Reopro Versus Alteplase to Treat Stoke Terminated NCT02016547 Phase 4 alteplase 0.9mg/kg (10% by IV bolus following by 90% by 1 hour IV drip)
4 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Unknown status NCT01758614 Phase 3 Aspirin;Clopidogrel
5 Ultrasound Enhanced Thrombolytic Therapy of Middle Cerebral Artery Occlusion Unknown status NCT00336596 Phase 3
6 Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion Completed NCT00777140 Phase 2 Deferoxamine
7 Safety and Feasibility of Argatroban, Tissue Plasminogen Activator and Intra-arterial Therapy in Stroke Completed NCT02448069 Phase 2 Argatroban
8 Superiority of Rt-PA + Tenecteplase in Comparison With Rt-PA Only in Proximal Middle Cerebral Artery Occlusion Withdrawn NCT02338466 Phase 2 rt-PA;tenecteplase
9 Neurothrombectomy France Completed NCT02880579
10 The Comparative Safety and Effectiveness of Warfarin and Dabigatran Prescribed in the Non-valvular Atrial Fibrillation Population With Humana Healthcare Coverage Completed NCT02061748 Observational
11 Berlin PRehospital Or Usual Delivery of Acute Stroke Care 2.0 (B_PROUD 2.0) Recruiting NCT03931616 Not Applicable
12 Berlin PRehospital Or Usual Delivery of Acute Stroke Care Recruiting NCT02869386 Not Applicable
13 Embolectomy in Acute SYlvian Thrombosis in Refractory or Ineligible Patients to ALteplase Terminated NCT02216565 Not Applicable Alteplase if patient is eligible

Search NIH Clinical Center for Cerebral Artery Occlusion

Genetic Tests for Cerebral Artery Occlusion

Anatomical Context for Cerebral Artery Occlusion

MalaCards organs/tissues related to Cerebral Artery Occlusion:

42
Brain, Cortex, Spinal Cord, Neutrophil, Endothelial, Heart, Bone

Publications for Cerebral Artery Occlusion

Articles related to Cerebral Artery Occlusion:

(show top 50) (show all 1683)
# Title Authors Year
1
Using the behavioral flexibility operant task to detect long-term deficits in rats following middle cerebral artery occlusion. ( 30107224 )
2019
2
Hyperbaric Oxygen Protects Against Cerebral Damage in Permanent Middle Cerebral Artery Occlusion Rats and Inhibits Autophagy Activity. ( 29987690 )
2019
3
Early initiation of a factor Xa inhibitor can attenuate tissue repair and neurorestoration after middle cerebral artery occlusion. ( 31103522 )
2019
4
The protective effects of Gastrodia elata Blume extracts on middle cerebral artery occlusion in rats. ( 31093444 )
2019
5
Preclinical concepts and results with the GABAA antagonist S44819 in a mouse model of middle cerebral artery occlusion. ( 31089046 )
2019
6
Predictors for basal ganglia viability after mechanical thrombectomy in proximal middle cerebral artery occlusion. ( 31078916 )
2019
7
Endovascular Clot Retrieval for M2 Segment Middle Cerebral Artery Occlusion: a systematic review and meta-analysis. ( 31059208 )
2019
8
Cortical tissue loss and major structural reorganization as result of distal middle cerebral artery occlusion in the chronic phase of nude mice. ( 31048718 )
2019
9
Early acid/base and electrolyte changes in permanent middle cerebral artery occlusion: Aged male and female rats. ( 30942522 )
2019
10
Identification and functional analysis of circular RNAs induced in rats by middle cerebral artery occlusion. ( 30914324 )
2019
11
A Genome-Wide Analysis of the Penumbral Volume in Inbred Mice following Middle Cerebral Artery Occlusion. ( 30911049 )
2019
12
Development of a Novel Canine Model of Ischemic Stroke: Skull Base Approach with Transient Middle Cerebral Artery Occlusion. ( 30898757 )
2019
13
Correction to: Human adipose-derived stem cells partially rescue the stroke syndromes by promoting spatial learning and memory in mouse middle cerebral artery occlusion model. ( 30841898 )
2019
14
Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion. ( 30816157 )
2019
15
Spreading depolarization and neuronal damage or survival in mouse neocortical brain slices immediately and 12 hours following middle cerebral artery occlusion. ( 30811255 )
2019
16
Middle Cerebral Artery Occlusion Allowing Reperfusion via Common Carotid Artery Repair in Mice. ( 30735149 )
2019
17
A novel rat model of cerebral artery occlusion complicated with prior venous stagnation. ( 30703390 )
2019
18
Effects of thrombolysis within 6 hours on acute cerebral infarction in an improved rat embolic middle cerebral artery occlusion model for ischaemic stroke. ( 30697923 )
2019
19
Increased expression of thymic stromal lymphopoietin receptor in a rat model of middle cerebral artery occlusion. ( 30676545 )
2019
20
Amide proton transfer-weighted MRI can detect tissue acidosis and monitor recovery in a transient middle cerebral artery occlusion model compared with a permanent occlusion model in rats. ( 30666450 )
2019
21
Bridging Therapy Versus Direct Mechanical Thrombectomy in Patients with Acute Ischemic Stroke due to Middle Cerebral Artery Occlusion: A Clinical-Histological Analysis of Retrieved Thrombi. ( 30654640 )
2019
22
Successful double mechanical thrombectomy in bilateral M1 middle cerebral artery occlusion. ( 30637667 )
2019
23
An enriched environment promotes synaptic plasticity and cognitive recovery after permanent middle cerebral artery occlusion in mice. ( 30539814 )
2019
24
Ultrasound-targeted microbubble enhances migration and therapeutic efficacy of marrow mesenchymal stem cell on rat middle cerebral artery occlusion stroke model. ( 30537289 )
2019
25
Quercetin Might Promote Autophagy in a Middle Cerebral Artery Occlusion-Mediated Ischemia Model: Comments on Fawad-Ali Shah et al. ( 30515707 )
2019
26
Strain differences in intraluminal thread model of middle cerebral artery occlusion in rats. ( 30433803 )
2019
27
'Governor vessel-unblocking and mind-regulating' acupuncture therapy ameliorates cognitive dysfunction in a rat model of middle cerebral artery occlusion. ( 30431067 )
2019
28
Survivin overexpression via adeno-associated virus vector Rh10 ameliorates ischemic damage after middle cerebral artery occlusion in rats. ( 30251448 )
2018
29
Crotalus atrox disintegrin reduces hemorrhagic transformation by attenuating matrix metalloproteinase-9 activity after middle cerebral artery occlusion in hyperglycemic male rats. ( 30242872 )
2018
30
Oncostatin M-induced upregulation of SDF-1 improves Bone marrow stromal cell migration in a rat middle cerebral artery occlusion stroke model. ( 30213507 )
2018
31
Effect of Ginkgo biloba extract-761 on motor functions in permanent middle cerebral artery occlusion rats. ( 30195885 )
2018
32
Mechanical Thrombectomy for Acute Anterior Cerebral Artery Occlusion. ( 30189299 )
2018
33
Fluctuations of Nutrition-Associated Markers After Decompressive Hemicraniectomy in Middle Cerebral Artery Occlusion Patients. ( 30178320 )
2018
34
Neuroprotective Effects of Cerebral Ischemic Preconditioning in a Rat Middle Cerebral Artery Occlusion Model: The Role of the Notch Signaling Pathway. ( 30175143 )
2018
35
Metabolomic Analysis of Mouse Brain after a Transient Middle Cerebral Artery Occlusion by Mass Spectrometry Imaging. ( 30078821 )
2018
36
Heptanoate is neuroprotective in vitro but triheptanoin post-treatment did not protect against middle cerebral artery occlusion in rats. ( 30076987 )
2018
37
Recombinant Tissue Plasminogen Activator-conjugated Nanoparticles Effectively Targets Thrombolysis in a Rat Model of Middle Cerebral Artery Occlusion. ( 30074208 )
2018
38
Thrombolysis with rt-PA under Rivaroxaban Anticoagulation in a Hypertensive Rat Model of Intraluminal Middle Cerebral Artery Occlusion. ( 30056000 )
2018
39
Evidence from functional ultrasound imaging of enhanced contralesional microvascular response to somatosensory stimulation in acute middle cerebral artery occlusion/reperfusion in rats: A marker of ultra-early network reorganization? ( 29972329 )
2018
40
Acute Right Middle Cerebral Artery Occlusion Resulting in Acute Systolic Heart Failure, Cerebral T-Waves, and QTc Prolongation: A Case Report. ( 29953038 )
2018
41
Comparison of Therapeutic Efficacy Between Isolated Encephaloduroarteriosynangiosis and Medical Treatment in Patients with Atherosclerotic Middle Cerebral Artery Occlusion. ( 29935318 )
2018
42
Identification of Proteins Differentially Expressed by Quercetin Treatment in a Middle Cerebral Artery Occlusion Model: A Proteomics Approach. ( 29926355 )
2018
43
Electroacupuncture: a new approach to open the blood-brain barrier in rats recovering from middle cerebral artery occlusion. ( 29903719 )
2018
44
Ginkgolide K promotes angiogenesis in a middle cerebral artery occlusion mouse model via activating JAK2/STAT3 pathway. ( 29890157 )
2018
45
Tail Vein Infusion of Adipose-Derived Mesenchymal Stem Cell Alleviated Inflammatory Response and Improved Blood Brain Barrier Condition by Suppressing Endoplasmic Reticulum Stress in a Middle Cerebral Artery Occlusion Rat Model. ( 29888735 )
2018
46
Ischemic Stroke Detection by Analyzing Heart Rate Variability in Rat Middle Cerebral Artery Occlusion Model. ( 29877839 )
2018
47
Dietary nitrate supplementation reduces low frequency blood pressure fluctuations in rats following distal middle cerebral artery occlusion. ( 29856262 )
2018
48
Characterization of the transient middle cerebral artery occlusion model of ischemic stroke in a HuR transgenic mouse line. ( 29854897 )
2018
49
Hypoxic postconditioning enhances functional recovery following endothelin-1 induced middle cerebral artery occlusion in conscious rats. ( 29778441 )
2018
50
Repeated Endovascular Treatment of Early Recurrent Proximal Middle Cerebral Artery Occlusion: Case Report and Brief Review of the Literature. ( 29774008 )
2018

Variations for Cerebral Artery Occlusion

Expression for Cerebral Artery Occlusion

Search GEO for disease gene expression data for Cerebral Artery Occlusion.

Pathways for Cerebral Artery Occlusion

Pathways related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.69 BDNF NOS2 NOS3 PTGS2
2
Show member pathways
12.3 BDNF NOS3 PTGS2 SORT1
3
Show member pathways
12.2 IL1RN NOS2 NOS3
4
Show member pathways
12.07 NOS2 NOS3 PTGS2
5
Show member pathways
11.85 IL1RN NOS2 PTGS2
6 11.58 BDNF NOS2 PTGS2
7
Show member pathways
11.36 NOS2 NOS3
8 11.29 NOS2 PTGS2
9 11.27 IL1RN PTGS2
10
Show member pathways
11.18 NOS2 NOS3
11
Show member pathways
11.15 NOS2 NOS3
12 11.1 NOS2 PTGS2
13
Show member pathways
11.09 NOS2 NOS3 ODC1
14 11.04 NOS2 PTGS2
15
Show member pathways
10.89 NOS2 NOS3
16 10.84 NOS2 NOS3
17 10.78 BDNF IL1RN NOS2 PTGS2
18 10.58 NOS2 NOS3 PTGS2
19 10.52 NOS2 NOS3
20 10.16 NOS2 NOS3

GO Terms for Cerebral Artery Occlusion

Cellular components related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.76 APOE BDNF HYAL2 IL1RN NOS2 NOS3
2 perinuclear region of cytoplasm GO:0048471 9.02 BDNF HYAL2 NOS2 ODC1 SORT1
3 vesicle membrane GO:0012506 8.96 NOS2 NOS3

Biological processes related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.73 IL1RN NOS2 PTGS2
2 response to lipopolysaccharide GO:0032496 9.69 NOS2 NOS3 PTGS2
3 response to hormone GO:0009725 9.58 NOS2 NOS3
4 negative regulation of MAP kinase activity GO:0043407 9.55 APOE HYAL2
5 positive regulation of protein import into nucleus GO:0042307 9.54 HYAL2 PTGS2
6 negative regulation of blood pressure GO:0045776 9.52 NOS2 NOS3
7 neurotrophin TRK receptor signaling pathway GO:0048011 9.49 BDNF SORT1
8 vasodilation GO:0042311 9.48 APOE NOS3
9 negative regulation of calcium ion transport GO:0051926 9.46 NOS3 PTGS2
10 nitric oxide biosynthetic process GO:0006809 9.43 NOS2 NOS3
11 nerve growth factor signaling pathway GO:0038180 9.4 BDNF SORT1
12 response to reactive oxygen species GO:0000302 9.37 APOE HYAL2
13 positive regulation of guanylate cyclase activity GO:0031284 9.32 NOS2 NOS3
14 sensory perception of pain GO:0019233 9.27 PTGS2
15 negative regulation of platelet activation GO:0010544 9.26 APOE NOS3
16 arginine catabolic process GO:0006527 9.16 NOS2 NOS3
17 memory GO:0007613 8.96 BDNF PTGS2
18 nitric oxide mediated signal transduction GO:0007263 8.8 APOE NOS2 NOS3

Molecular functions related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.73 APOE NOS2 ODC1 PTGS2
2 heme binding GO:0020037 9.54 NOS2 NOS3 PTGS2
3 NADP binding GO:0050661 9.4 NOS2 NOS3
4 FMN binding GO:0010181 9.32 NOS2 NOS3
5 arginine binding GO:0034618 9.26 NOS2 NOS3
6 NADPH-hemoprotein reductase activity GO:0003958 9.16 NOS2 NOS3
7 tetrahydrobiopterin binding GO:0034617 8.96 NOS2 NOS3
8 nitric-oxide synthase activity GO:0004517 8.62 NOS2 NOS3

Sources for Cerebral Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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