MCID: CRB004
MIFTS: 45

Cerebral Artery Occlusion

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Cerebral Artery Occlusion

MalaCards integrated aliases for Cerebral Artery Occlusion:

Name: Cerebral Artery Occlusion 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:10127
ICD9CM 35 434 434.9
SNOMED-CT 68 20059004
UMLS 73 C0028790

Summaries for Cerebral Artery Occlusion

MalaCards based summary : Cerebral Artery Occlusion is related to brain injury and dementia. An important gene associated with Cerebral Artery Occlusion is BDNF (Brain Derived Neurotrophic Factor), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. The drugs Abciximab and Tissue Plasminogen Activator have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and endothelial, and related phenotypes are Increased LDL uptake and cellular

Related Diseases for Cerebral Artery Occlusion

Diseases related to Cerebral Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 brain injury 30.7 BDNF APOE
2 dementia 29.5 TNF BDNF APOE
3 ischemia 10.7
4 brain edema 10.4
5 stroke, ischemic 10.3
6 hypoxia 10.2
7 brain ischemia 10.2
8 jejunoileitis 10.1 TNF GDNF
9 idiopathic achalasia 10.1 TNF NOS2
10 dystrophinopathies 10.1 TNF NOS2
11 crohn's colitis 10.1 TNF NOS2
12 vertebral artery occlusion 10.1 NOS2 BDNF
13 arthus reaction 10.1 TNF NOS2
14 drug-induced hearing loss 10.1 GDNF BDNF
15 eales disease 10.1 TNF NOS2
16 brachial plexus lesion 10.1 GDNF BDNF
17 spinal cord disease 10.1 TNF GDNF
18 traumatic brain injury 10.1 BDNF APOE
19 ischemic heart disease 10.1 TNF APOE
20 mutism 10.1
21 hyperglycemia 10.1
22 akinetic mutism 10.1
23 carotid artery dissection 10.1
24 pyosalpinx 10.1 NOS2 APOE
25 bacterial sepsis 10.0 TNF NOS2
26 sleeping sickness 10.0 ODC1 NOS2
27 hepatopulmonary syndrome 10.0 TNF NOS2
28 inclusion conjunctivitis 10.0 TNF IL16
29 cerebral hemorrhage 10.0
30 hemiplegia 10.0
31 depression 10.0
32 carotid stenosis 10.0 TNF APOE
33 louse-borne relapsing fever 10.0 TNF MAPK1
34 major depressive disorder 10.0 TNF BDNF APOE
35 aphasia 9.9 BDNF APOE
36 atrophic gastritis 9.9 TNF ODC1
37 moyamoya disease 1 9.9
38 neonatal stroke 9.9
39 infective endocarditis 9.9
40 endocarditis 9.9
41 cerebral hypoxia 9.9
42 dermatitis, atopic 9.9 TNF IL16 BDNF
43 acute vascular insufficiency of intestine 9.8 TNF MAPK1 GDNF
44 central nervous system disease 9.8 TNF NOS2 BDNF APOE
45 multiple sclerosis 9.8 TNF NOS2 BDNF APOE
46 cerebral amyloid angiopathy, cst3-related 9.8
47 arteries, anomalies of 9.8
48 temporal arteritis 9.8
49 neutrophil actin dysfunction 9.8
50 aging 9.8

Graphical network of the top 20 diseases related to Cerebral Artery Occlusion:



Diseases related to Cerebral Artery Occlusion

Symptoms & Phenotypes for Cerebral Artery Occlusion

GenomeRNAi Phenotypes related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased LDL uptake GR00340-A-1 8.62 APOE SORT1

MGI Mouse Phenotypes related to Cerebral Artery Occlusion:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.11 APOE BDNF GDNF MAPK1 NOS2 ODC1
2 mortality/aging MP:0010768 10.01 APOE BDNF GDNF MAPK1 NOS2 ODC1
3 cardiovascular system MP:0005385 10 APOE GDNF MAPK1 NOS2 SORT1 TNF
4 growth/size/body region MP:0005378 10 APOE BDNF GDNF MAPK1 NOS2 ODC1
5 immune system MP:0005387 9.98 APOE GDNF IL16 MAPK1 NOS2 SORT1
6 digestive/alimentary MP:0005381 9.97 APOE BDNF GDNF MAPK1 NOS2 TNF
7 endocrine/exocrine gland MP:0005379 9.95 APOE BDNF GDNF MAPK1 NOS2 TNF
8 nervous system MP:0003631 9.87 APOE BDNF GDNF MAPK1 NOS2 SORT1
9 muscle MP:0005369 9.85 APOE GDNF MAPK1 NOS2 SORT1 TNF
10 reproductive system MP:0005389 9.73 APOE BDNF GDNF MAPK1 NOS2 TNF
11 respiratory system MP:0005388 9.55 APOE BDNF MAPK1 NOS2 TNF
12 taste/olfaction MP:0005394 9.13 APOE BDNF MAPK1
13 vision/eye MP:0005391 9.1 APOE BDNF MAPK1 NOS2 SORT1 TNF

Drugs & Therapeutics for Cerebral Artery Occlusion

Drugs for Cerebral Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abciximab Approved Phase 4 143653-53-6
2 Tissue Plasminogen Activator Phase 4,Phase 3,Phase 2,Not Applicable
3 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Not Applicable
4 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2
5 Plasminogen Phase 4,Phase 2,Not Applicable
6 Anticoagulants Phase 4,Phase 2
7 Mitogens Phase 4
8 Antibodies Phase 4
9 Immunoglobulins Phase 4
10 Immunoglobulin Fab Fragments Phase 4
11 Antibodies, Monoclonal Phase 4
12 Immunologic Factors Phase 4
13
Clopidogrel Approved Phase 3 113665-84-2, 120202-66-6 60606
14
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
15
Ticlopidine Approved Phase 3 55142-85-3 5472
16 Analgesics, Non-Narcotic Phase 3
17 Purinergic P2Y Receptor Antagonists Phase 3
18 Analgesics Phase 3
19 Cytochrome P-450 Enzyme Inhibitors Phase 3
20 Peripheral Nervous System Agents Phase 3
21 Cytochrome P-450 CYP2C19 Inhibitors Phase 3
22 Anti-Inflammatory Agents, Non-Steroidal Phase 3
23 Purinergic P2 Receptor Antagonists Phase 3
24 Antirheumatic Agents Phase 3
25 Cyclooxygenase Inhibitors Phase 3
26 Neurotransmitter Agents Phase 3
27 Antipyretics Phase 3
28 Anti-Inflammatory Agents Phase 3
29
Iron Approved Phase 2 7439-89-6 23925
30
Deferoxamine Approved, Investigational Phase 2 70-51-9 2973
31
Argatroban Approved, Investigational Phase 2 74863-84-6 152951
32
Serine Approved, Nutraceutical Phase 2 56-45-1 5951
33 Pharmaceutical Solutions Phase 2
34 Iron Chelating Agents Phase 2
35 Chelating Agents Phase 2
36 Antithrombin III Phase 2
37
protease inhibitors Phase 2
38 HIV Protease Inhibitors Phase 2
39 Antithrombins Phase 2
40 Serine Proteinase Inhibitors Phase 2
41
Warfarin Approved 81-81-2 6691 54678486
42 Dabigatran

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 A Randomized Double Blind Placebo Control Study of Huang-Chi-Wu-Wu- Tang in Patients With Intracranial Arterial Stenosis Unknown status NCT01553643 Phase 4 Chinese Herb Huang-Chi-Wu-Wu-Tang;placebo
2 Effects of Intranasal Nerve Growth Factor for Acute Ischemic Stroke Recruiting NCT03686163 Phase 4 Nerve Growth Factors;normal saline
3 Thrombectomy Under Reopro Versus Alteplase to Treat Stoke Terminated NCT02016547 Phase 4 alteplase 0.9mg/kg (10% by IV bolus following by 90% by 1 hour IV drip)
4 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Unknown status NCT01758614 Phase 3 Aspirin;Clopidogrel
5 Ultrasound Enhanced Thrombolytic Therapy of Middle Cerebral Artery Occlusion Unknown status NCT00336596 Phase 3
6 Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion Completed NCT00777140 Phase 2 Deferoxamine
7 Safety and Feasibility of Argatroban, Tissue Plasminogen Activator and Intra-arterial Therapy in Stroke Completed NCT02448069 Phase 2 Argatroban
8 Superiority of Rt-PA + Tenecteplase in Comparison With Rt-PA Only in Proximal Middle Cerebral Artery Occlusion Withdrawn NCT02338466 Phase 2 rt-PA;tenecteplase
9 Use of Hypothermia During Robotic Prostatectomy Unknown status NCT00915031 Not Applicable
10 Neurothrombectomy France Completed NCT02880579
11 The Comparative Safety and Effectiveness of Warfarin and Dabigatran Prescribed in the Non-valvular Atrial Fibrillation Population With Humana Healthcare Coverage Completed NCT02061748 Observational
12 Berlin PRehospital Or Usual Delivery of Acute Stroke Care Recruiting NCT02869386 Not Applicable
13 Embolectomy in Acute SYlvian Thrombosis in Refractory or Ineligible Patients to ALteplase Terminated NCT02216565 Not Applicable Alteplase if patient is eligible

Search NIH Clinical Center for Cerebral Artery Occlusion

Genetic Tests for Cerebral Artery Occlusion

Anatomical Context for Cerebral Artery Occlusion

MalaCards organs/tissues related to Cerebral Artery Occlusion:

41
Brain, Bone, Endothelial, Cortex, Bone Marrow, Heart, Spinal Cord

Publications for Cerebral Artery Occlusion

Articles related to Cerebral Artery Occlusion:

(show top 50) (show all 1035)
# Title Authors Year
1
'Governor vessel-unblocking and mind-regulating' acupuncture therapy ameliorates cognitive dysfunction in a rat model of middle cerebral artery occlusion. ( 30431067 )
2019
2
An enriched environment promotes synaptic plasticity and cognitive recovery after permanent middle cerebral artery occlusion in mice. ( 30539814 )
2019
3
Using the behavioral flexibility operant task to detect long-term deficits in rats following middle cerebral artery occlusion. ( 30107224 )
2019
4
Progression of vasogenic edema induced by activated microglia under permanent middle cerebral artery occlusion. ( 29353043 )
2018
5
Middle Cerebral Artery Occlusion by an Intraluminal Suture Method. ( 29222799 )
2018
6
Dietary nitrate supplementation reduces low frequency blood pressure fluctuations in rats following distal middle cerebral artery occlusion. ( 29856262 )
2018
7
Acute Right Middle Cerebral Artery Occlusion Resulting in Acute Systolic Heart Failure, Cerebral T-Waves, and QTc Prolongation: A Case Report. ( 29953038 )
2018
8
Delayed Recanalization Promotes Functional Recovery in Rats Following Permanent Middle Cerebral Artery Occlusion. ( 29354887 )
2018
9
Ginkgolide K promotes angiogenesis in a middle cerebral artery occlusion mouse model via activating JAK2/STAT3 pathway. ( 29890157 )
2018
10
Effect of laser Doppler flowmetry and occlusion time on outcome variability and mortality in rat middle cerebral artery occlusion: inconclusive results. ( 29673328 )
2018
11
Intravenously Delivered Allogeneic Mesenchymal Stem Cells Bidirectionally Regulate Inflammation and Induce Neurotrophic Effects in Distal Middle Cerebral Artery Occlusion Rats Within the First 7 Days After Stroke. ( 29719282 )
2018
12
Neuronal loss and gliosis in the rat striatum subjected to 15 and 30 minutes of middle cerebral artery occlusion. ( 29354885 )
2018
13
The degree of leukoaraiosis predicts clinical outcomes and prognosis in patients with middle cerebral artery occlusion after intravenous thrombolysis. ( 29288062 )
2018
14
Epigallocatechin-3-Gallate Reduces Neuronal Apoptosis in Rats after Middle Cerebral Artery Occlusion Injury via PI3K/AKT/eNOS Signaling Pathway. ( 29770336 )
2018
15
Ischemic Stroke Detection by Analyzing Heart Rate Variability in Rat Middle Cerebral Artery Occlusion Model. ( 29877839 )
2018
16
MicroRNA-149-5p regulates blood-brain barrier permeability after transient middle cerebral artery occlusion in rats by targeting S1PR2 of pericytes. ( 29401609 )
2018
17
Hypoxic postconditioning enhances functional recovery following endothelin-1 induced middle cerebral artery occlusion in conscious rats. ( 29778441 )
2018
18
Licorice Pretreatment Protects Against Brain Damage Induced by Middle Cerebral Artery Occlusion in Mice. ( 29341803 )
2018
19
Electroacupuncture: a new approach to open the blood-brain barrier in rats recovering from middle cerebral artery occlusion. ( 29903719 )
2018
20
Identification of Proteins Differentially Expressed by Quercetin Treatment in a Middle Cerebral Artery Occlusion Model: A Proteomics Approach. ( 29926355 )
2018
21
Bilateral Middle Cerebral Artery Occlusion In Rapid Succession During Thrombolysis. ( 29623161 )
2018
22
Long non-coding RNA RMST silencing protects against middle cerebral artery occlusion (MCAO)-induced ischemic stroke. ( 29258823 )
2018
23
Citalopram attenuated neurobehavioral, biochemical, and metabolic alterations in transient middle cerebral artery occlusion model of stroke in male Wistar rats. ( 29656429 )
2018
24
Evidence from functional ultrasound imaging of enhanced contralesional microvascular response to somatosensory stimulation in acute middle cerebral artery occlusion/reperfusion in rats: A marker of ultra-early network reorganization? ( 29972329 )
2018
25
Comparison of therapeutic efficacy between isolated encephaloduroarteriosynangiosis and medical treatment in patients with atherosclerotic middle cerebral artery occlusion. ( 29935318 )
2018
26
Tirofiban combined with rt-PA intraarterial thrombolysis improves the recanalization rate of acute middle cerebral artery occlusion in rabbits. ( 29771445 )
2018
27
Dipyridamole plus Triflusal versus Triflusal Alone in Infarct Reduction after Middle Cerebral Artery Occlusion. ( 29338983 )
2018
28
Tail Vein Infusion of Adipose-Derived Mesenchymal Stem Cell Alleviated Inflammatory Response and Improved Blood Brain Barrier Condition by Suppressing Endoplasmic Reticulum Stress in a Middle Cerebral Artery Occlusion Rat Model. ( 29888735 )
2018
29
Mechanical Thrombectomy of Acute Middle Cerebral Artery Occlusion using Trans-Anterior Communicating Artery Approach. ( 29339323 )
2018
30
Protective effects of beef decoction rich in carnosine on cerebral ischemia injury by permanent middle cerebral artery occlusion in rats. ( 29399121 )
2018
31
Targeted Temperature Management at 33A^C or 36A^C Produces Equivalent Neuroprotective Effects in the Middle Cerebral Artery Occlusion Rat Model of Ischemic Stroke. ( 29337840 )
2018
32
Repeated Endovascular Treatment of Early Recurrent Proximal Middle Cerebral Artery Occlusion: Case Report and Brief Review of the Literature. ( 29774008 )
2018
33
Predictors of short-term outcome in patients with acute middle cerebral artery occlusion: unsuitability of fluid-attenuated inversion recovery vascular hyperintensity scores. ( 29451209 )
2018
34
Ischemia Reperfusion Injury after Gradual versus Rapid Flow Restoration for Middle Cerebral Artery Occlusion Rats. ( 29374244 )
2018
35
Myricetin against ischemic cerebral injury in rat middle cerebral artery occlusion model. ( 29257250 )
2018
36
Netrin-1 attenuates brain injury after middle cerebral artery occlusion via downregulation of astrocyte activation in mice. ( 30227858 )
2018
37
Fluctuations of Nutrition-Associated Markers After Decompressive Hemicraniectomy in Middle Cerebral Artery Occlusion Patients. ( 30178320 )
2018
38
Mechanical Thrombectomy for Acute Anterior Cerebral Artery Occlusion. ( 30189299 )
2018
39
Effect of Ginkgo biloba extract-761 on motor functions in permanent middle cerebral artery occlusion rats. ( 30195885 )
2018
40
Oncostatin M-induced upregulation of SDF-1 improves Bone marrow stromal cell migration in a rat middle cerebral artery occlusion stroke model. ( 30213507 )
2018
41
Crotalus atrox disintegrin reduces hemorrhagic transformation by attenuating matrix metalloproteinase-9 activity after middle cerebral artery occlusion in hyperglycemic male rats. ( 30242872 )
2018
42
Survivin overexpression via adeno-associated virus vector Rh10 ameliorates ischemic damage after middle cerebral artery occlusion in rats. ( 30251448 )
2018
43
Transradial Mechanical Thrombectomy for Proximal Middle Cerebral Artery Occlusion in a First Trimester Pregnancy: Case Report and Literature Review. ( 30261390 )
2018
44
Celecoxib Treatment Improves Neurologic Deficit and Reduces Selective Neuronal Loss and Glial Response in Rats after Transient Middle Cerebral Artery Occlusion. ( 30291174 )
2018
45
Effects of Dehydration on Brain Perfusion and Infarct Core After Acute Middle Cerebral Artery Occlusion in Rats: Evidence From High-Field Magnetic Resonance Imaging. ( 30294297 )
2018
46
Diabetes mellitus inhibits complete recanalization in patients with middle cerebral artery occlusion. ( 30319049 )
2018
47
Right Insular Cortex Ischemia Caused by Middle Cerebral Artery Occlusion: A Possible Pathogenesis of Decreased Sympathetic Nervous System Activity? ( 30379744 )
2018
48
Implications of Mechanical Endovascular Thrombectomy for Acute Basilar and Posterior Cerebral Artery Occlusion. ( 30397588 )
2018
49
MicroRNA-122 Mimic Improves Stroke Outcomes and Indirectly Inhibits NOS2 After Middle Cerebral Artery Occlusion in Rats. ( 30405345 )
2018
50
Neuroprotective Effect of IRL-1620, an Endothelin B Receptor Agonist, on a Pediatric Rat Model of Middle Cerebral Artery Occlusion. ( 30406063 )
2018

Variations for Cerebral Artery Occlusion

Expression for Cerebral Artery Occlusion

Search GEO for disease gene expression data for Cerebral Artery Occlusion.

Pathways for Cerebral Artery Occlusion

Pathways related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.33 BDNF GDNF IL16 MAPK1 NOS2 TNF
2
Show member pathways
13.08 GDNF IL16 MAPK1 NOS2 TNF
3
Show member pathways
12.06 MAPK1 NOS2 TNF
4
Show member pathways
12 MAPK1 NOS2 TNF
5 11.97 MAPK1 NOS2 TNF
6
Show member pathways
11.92 MAPK1 NOS2 TNF
7
Show member pathways
11.86 BDNF GDNF MAPK1
8 11.83 MAPK1 NOS2 TNF
9 11.74 BDNF MAPK1 SORT1
10 11.38 MAPK1 NOS2 TNF
11 11.31 MAPK1 TNF
12 11.3 NOS2 TNF
13 11.28 BDNF NOS2 TNF
14 11.27 APOE MAPK1
15 11.26 APOE TNF
16 11.25 MAPK1 TNF
17 11.18 GDNF MAPK1
18
Show member pathways
11.13 MAPK1 NOS2 TNF
19 11.12 BDNF MAPK1
20 11.1 BDNF GDNF MAPK1 NOS2 TNF
21 11.01 BDNF MAPK1
22 10.94 MAPK1 TNF
23 10.87 MAPK1 TNF
25 10.68 BDNF IL16 MAPK1 TNF
26 10.51 BDNF MAPK1

GO Terms for Cerebral Artery Occlusion

Cellular components related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 early endosome GO:0005769 9.33 APOE MAPK1 SORT1
2 perinuclear region of cytoplasm GO:0048471 9.26 BDNF NOS2 ODC1 SORT1
3 extracellular region GO:0005576 9.1 APOE BDNF GDNF IL16 MAPK1 TNF

Biological processes related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.73 IL16 NOS2 TNF
2 negative regulation of gene expression GO:0010629 9.72 APOE NOS2 TNF
3 MAPK cascade GO:0000165 9.65 GDNF MAPK1 TNF
4 axon guidance GO:0007411 9.61 BDNF GDNF MAPK1
5 negative regulation of fat cell differentiation GO:0045599 9.57 SORT1 TNF
6 negative regulation of endothelial cell proliferation GO:0001937 9.54 APOE TNF
7 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.52 GDNF TNF
8 lipopolysaccharide-mediated signaling pathway GO:0031663 9.51 MAPK1 TNF
9 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.49 SORT1 TNF
10 peripheral nervous system development GO:0007422 9.46 BDNF GDNF
11 regulation of signaling receptor activity GO:0010469 9.46 BDNF GDNF IL16 TNF
12 negative regulation of neuron apoptotic process GO:0043524 9.43 APOE BDNF GDNF
13 neurotrophin TRK receptor signaling pathway GO:0048011 9.4 BDNF SORT1
14 nitric oxide mediated signal transduction GO:0007263 9.37 APOE NOS2
15 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.32 APOE TNF
16 nerve growth factor signaling pathway GO:0038180 8.96 BDNF SORT1
17 regulation of gene expression GO:0010468 8.92 APOE GDNF MAPK1 SORT1

Molecular functions related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 8.92 APOE GDNF NOS2 ODC1

Sources for Cerebral Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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