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MCID: CRB004
MIFTS: 44

Cerebral Artery Occlusion

Categories: Cardiovascular diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cerebral Artery Occlusion

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MalaCards integrated aliases for Cerebral Artery Occlusion:

Name: Cerebral Artery Occlusion 12 15

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:10127
ICD9CM 34 434 434.9
SNOMED-CT 67 20059004
UMLS 71 C0028790
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Summaries for Cerebral Artery Occlusion

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MalaCards based summary : Cerebral Artery Occlusion is related to brain injury and brain edema. An important gene associated with Cerebral Artery Occlusion is BDNF (Brain Derived Neurotrophic Factor), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. The drugs Labetalol and Nicardipine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and endothelial, and related phenotypes are homeostasis/metabolism and behavior/neurological

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Related Diseases for Cerebral Artery Occlusion

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Diseases related to Cerebral Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 287)
# Related Disease Score Top Affiliating Genes
1 brain injury 31.4 BDNF AQP4 APOE
2 brain edema 31.0 IL1RN IL1B AQP4
3 carotid stenosis 30.7 TNF NOS3 APOE
4 ischemia 30.7 NOS3 IL1RN HIF1A BDNF
5 traumatic brain injury 30.6 BDNF AQP4 APOE
6 retinal ischemia 30.3 TNF HIF1A CNTF BDNF
7 intracranial aneurysm 30.1 TNF NOS3 APOE
8 vascular dementia 30.1 TNF IL1B APOE
9 meningitis 29.9 TNF IL1B GDNF AQP4
10 atherosclerosis susceptibility 29.9 TNF NOS3 IL1B APOE
11 stroke, ischemic 29.9 NOS3 GDNF BDNF AQP4 APOE ADM
12 narcolepsy 29.8 TNF GDNF BDNF AQP4 APOE
13 migraine with or without aura 1 29.4 TNF PTGS2 NOS3 IL1B BDNF ADM
14 hydrocephalus 29.4 TNF GDNF CNTF BDNF AQP4 APOE
15 coronary artery anomaly 29.3 TNF NOS3 IL1RN IL1B ADM
16 diabetes mellitus 28.9 TNF PTGS2 NOS3 IL1RN IL1B BDNF
17 myocardial infarction 28.6 TNF PTGS2 NOS3 IL1RN IL1B HIF1A
18 alzheimer disease 28.5 TNF PTGS2 NOS3 IL1B GDNF CNTF
19 autoimmune disease 28.5 TNF IL1RN IL1RAPL2 IL1B IL16
20 diabetes mellitus, noninsulin-dependent 28.1 TNF PTGS2 NOS3 IL1RN IL1B CNTF
21 hydrops, lactic acidosis, and sideroblastic anemia 10.6
22 hemiplegia 10.5
23 transient cerebral ischemia 10.5
24 staphylococcal toxic shock syndrome 10.5 TNF IL1B
25 mesial temporal lobe epilepsy with hippocampal sclerosis 10.5 IL1B APOE
26 jejunoileitis 10.4 TNF GDNF
27 palladium allergic contact dermatitis 10.4 TNF IL1B
28 kashin-beck disease 10.4 TNF IL1B
29 hyperglycemia 10.4
30 moyamoya disease 1 10.4
31 carotid artery occlusion 10.4
32 aphasia 10.4
33 meningoencephalitis 10.4 TNF GDNF BDNF
34 cerebrovascular disease 10.4
35 apnea, obstructive sleep 10.4 TNF NOS3 APOE
36 congenital cytomegalovirus 10.4 TNF IL1B
37 48,xyyy 10.4
38 dry eye syndrome 10.3 TNF GDNF BDNF
39 endometrial disease 10.3 TNF PTGS2 IL1B
40 viral encephalitis 10.3 TNF PTGS2 IL1B
41 peripheral artery disease 10.3 TNF NOS3 APOE
42 primary progressive multiple sclerosis 10.3 TNF BDNF APOE
43 lumbosacral plexus lesion 10.3 CNTF BDNF
44 actinic prurigo 10.3 TNF IL1B
45 autoimmune optic neuritis 10.3 CNTF AQP4
46 limb ischemia 10.3 TNF NOS3 HIF1A
47 age-related hearing loss 10.3 HIF1A APOE
48 intracranial hypertension 10.3 TNF IL1B AQP4
49 vascular disease 10.3
50 bone deterioration disease 10.3 TNF IL1B ADAMTS4

Graphical network of the top 20 diseases related to Cerebral Artery Occlusion:



Diseases related to Cerebral Artery Occlusion
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Symptoms & Phenotypes for Cerebral Artery Occlusion

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MGI Mouse Phenotypes related to Cerebral Artery Occlusion:

45 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.37 ADAMTS1 ADM APOE AQP4 BDNF CNTF
2 behavior/neurological MP:0005386 10.35 ADAMTS4 ADM APOE AQP4 BDNF CNTF
3 cardiovascular system MP:0005385 10.35 ADM APOE AQP4 CYGB EPHA3 GDNF
4 cellular MP:0005384 10.34 ADM APOE BDNF CNTF CYGB GDNF
5 growth/size/body region MP:0005378 10.34 ADAMTS1 APOE AQP4 BDNF GDNF HIF1A
6 mortality/aging MP:0010768 10.34 ADAMTS1 ADAMTS4 ADM APOE AQP4 BDNF
7 hematopoietic system MP:0005397 10.32 ADM APOE AQP4 CNTF GDNF HIF1A
8 endocrine/exocrine gland MP:0005379 10.31 ADAMTS1 ADM APOE AQP4 BDNF CNTF
9 immune system MP:0005387 10.29 ADM APOE AQP4 CNTF GDNF HIF1A
10 digestive/alimentary MP:0005381 10.15 APOE AQP4 BDNF GDNF HIF1A NOS3
11 liver/biliary system MP:0005370 10.11 ADM APOE CYGB EPHA3 HIF1A HYAL2
12 nervous system MP:0003631 10.11 ADAMTS4 APOE AQP4 BDNF CNTF GDNF
13 muscle MP:0005369 10.06 ADM APOE CNTF CYGB GDNF HIF1A
14 renal/urinary system MP:0005367 10 ADAMTS1 ADAMTS4 ADM APOE AQP4 CYGB
15 no phenotypic analysis MP:0003012 9.92 ADAMTS4 APOE AQP4 BDNF CNTF HYAL2
16 reproductive system MP:0005389 9.9 ADAMTS1 ADM APOE BDNF CNTF CYGB
17 respiratory system MP:0005388 9.61 ADM APOE AQP4 BDNF EPHA3 HIF1A
18 skeleton MP:0005390 9.28 ADAMTS4 APOE HIF1A HYAL2 IL1B IL1RN
Sources

Drugs & Therapeutics for Cerebral Artery Occlusion

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Drugs for Cerebral Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Labetalol Approved Phase 4 36894-69-6 3869
2
Nicardipine Approved, Investigational Phase 4 55985-32-5 4474
3
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
4 Mitogens Phase 4
5 Neurotransmitter Agents Phase 4
6 Antihypertensive Agents Phase 4
7 Sympathomimetics Phase 4
8 Adrenergic alpha-Antagonists Phase 4
9 Adrenergic beta-Antagonists Phase 4
10 Adrenergic Antagonists Phase 4
11 Vasodilator Agents Phase 4
12 Autonomic Agents Phase 4
13 Calcium, Dietary Phase 4
14 calcium channel blockers Phase 4
15 Adrenergic Agents Phase 4
16 Hormones Phase 4
17
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
18
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
19 Fibrinolytic Agents Phase 3
20 Tissue Plasminogen Activator Phase 3
21 Anti-Inflammatory Agents Phase 3
22 Antipyretics Phase 3
23 Anti-Inflammatory Agents, Non-Steroidal Phase 3
24 Platelet Aggregation Inhibitors Phase 3
25 Analgesics, Non-Narcotic Phase 3
26 Cyclooxygenase Inhibitors Phase 3
27 Antirheumatic Agents Phase 3
28 Purinergic P2Y Receptor Antagonists Phase 3
29 Analgesics Phase 3
30
Iron Approved, Experimental Phase 2 7439-89-6, 15438-31-0 23925 27284
31
Deferoxamine Approved, Investigational Phase 2 70-51-9 2973
32
Fibrinolysin Investigational Phase 1, Phase 2 9004-09-5
33 Siderophores Phase 2
34 Iron Chelating Agents Phase 2
35 Chelating Agents Phase 2
36 Anesthetics

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Effects of Intranasal Nerve Growth Factor for Acute Ischemic Stroke Recruiting NCT03686163 Phase 4 Nerve Growth Factors;normal saline
2 Outcome in Patients Treated With Intraarterial Thrombectomy - optiMAL Blood Pressure Control (OPTIMAL-BP) Not yet recruiting NCT04205305 Phase 4 conventional blood pressure control (labetalol, nicardipine);intensive blood pressure control (labetalol, nicardipine)
3 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Unknown status NCT01758614 Phase 3 Aspirin;Clopidogrel
4 Transcranial Ultrasound Enhanced Thrombolysis (TRUST) Unknown status NCT00336596 Phase 3
5 A Phase 1/2a, Open Label, Dose Escalation, Safety Study of Intra-thrombus Plasmin (Human) Administration in Acute, Middle Cerebral Artery, Ischemic Stroke Completed NCT01014975 Phase 1, Phase 2
6 Double-blind, Randomized, Placebo Controlled, Dose-finding Phase 2 Clinical Trial of Intravenous Deferoxamine in Patients With Acute Ischemic Stroke Treated With Tissue Plasminogen Activator Completed NCT00777140 Phase 2 Deferoxamine
7 Randomized Therapeutic Study Assessing the Superiority of a Sequential Intravenous Thrombolysis Treatment (Rt-PA + Tenecteplase) in Comparison With Rt-PA Standard Treatment in Proximal Middle Cerebral Artery Occlusion (DIVA). Withdrawn NCT02338466 Phase 2 rt-PA;tenecteplase
8 Remote Ischaemic Conditioning in Endovascular Recanalization for Proximal Anterior Circulation Occlusion (RICE PAC) Study Not yet recruiting NCT03152799 Phase 1
9 Incidence, Nature and Consequences of Cortical Depolarizations in Human Brain Injury From Trauma and Ischemia: The COSBID Study Unknown status NCT00258505
10 Transcranial Direct Current Stimulation (tDCS) in Acute Stroke Patients Unknown status NCT02806856
11 Evaluation of Clinical Results of Treatment of Cerebral Artery Occlusion by Mechanical Thrombectomy, in the Acute Phase of Stroke Completed NCT02880579
12 FRench Acute Cerebral Multimodal Imaging to Select Patient for MEchanical Thrombectomy Completed NCT03045146
13 Remote Ischemic Preconditioning for Carotid Endarterectomy Completed NCT02808754
14 Benefits of the Endovascular Treatment in the Early Management of Proximal Sylvian Artery Thrombosis in Patients Refractory or Ineligible to Intravenous Fibrinolysis : a Multicenter Controled Randomized Trial Terminated NCT02216565 Alteplase if patient is eligible

Search NIH Clinical Center for Cerebral Artery Occlusion

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Genetic Tests for Cerebral Artery Occlusion

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Anatomical Context for Cerebral Artery Occlusion

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MalaCards organs/tissues related to Cerebral Artery Occlusion:

40
Brain, Bone, Endothelial, Bone Marrow, Cortex, Neutrophil, T Cells
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Publications for Cerebral Artery Occlusion

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Articles related to Cerebral Artery Occlusion:

(show top 50) (show all 10581)
# Title Authors PMID Year
1
XingNaoJing injection ameliorates cerebral ischaemia/reperfusion injury via SIRT1-mediated inflammatory response inhibition. 61
31854225 2020
2
Modified constraint-induced movement therapy alters synaptic plasticity of rat contralateral hippocampus following middle cerebral artery occlusion. 61
31823884 2020
3
Achyranthes bidentata polypeptides prevent apoptosis by inhibiting the glutamate current in cultured hippocampal neurons. 61
31823889 2020
4
Selective brain hypothermia-induced neuroprotection against focal cerebral ischemia/reperfusion injury is associated with Fis1 inhibition. 61
31719256 2020
5
Neuroprotection of Cyperus esculentus L. orientin against cerebral ischemia/reperfusion induced brain injury. 61
31571667 2020
6
Neuroprotective effects of leptin on cerebral ischemia through JAK2/STAT3/PGC-1-mediated mitochondrial function modulation. 61
31935431 2020
7
Long non-coding RNA MEG3 promotes cerebral ischemia-reperfusion injury through increasing pyroptosis by targeting miR-485/AIM2 axis. 61
31794744 2020
8
Upregulated microRNA-31 inhibits oxidative stress-induced neuronal injury through the JAK/STAT3 pathway by binding to PKD1 in mice with ischemic stroke. 61
31517390 2020
9
Ginkgo diterpene lactones inhibit cerebral ischemia/reperfusion induced inflammatory response in astrocytes via TLR4/NF-κB pathway in rats. 61
31678414 2020
10
Cerebral ischemia-reperfusion causes a down regulation of HCN1 expression via enhancing the nuclear NRSF-HDAC4 gathering that contributes to neuron damage. 61
31923455 2020
11
JNK-IN-8, a c-Jun N-terminal kinase inhibitor, improves functional recovery through suppressing neuroinflammation in ischemic stroke. 61
31541462 2020
12
Cerebral ischemia-reperfusion aggravated cerebral infarction injury and possible differential genes identified by RNA-Seq in rats. 61
31877338 2020
13
Ischemic preconditioning provides long-lasting neuroprotection against ischemic stroke: The role of Nrf2. 61
31812555 2020
14
Pharmacological hypothermia induced neurovascular protection after severe stroke of transient middle cerebral artery occlusion in mice. 61
31770520 2020
15
DDAH-1 via HIF-1 target genes improves cerebral ischemic tolerance after hypoxic preconditioning and middle cerebral artery occlusion-reperfusion. 61
31870966 2020
16
MicroRNA-126-3p/-5p Overexpression Attenuates Blood-Brain Barrier Disruption in a Mouse Model of Middle Cerebral Artery Occlusion. 61
31822249 2020
17
RNPS1 inhibition aggravates ischemic brain injury and promotes neuronal death. 61
31831174 2020
18
Salidroside Restores an Anti-inflammatory Endothelial Phenotype by Selectively Inhibiting Endothelial Complement After Oxidative Stress. 61
31701353 2020
19
Mir-155 knockout protects against ischemia/reperfusion-induced brain injury and hemorrhagic transformation. 61
31876686 2020
20
Pseudoginsenoside-F11 improves long-term neurological function and promotes neurogenesis after transient cerebral ischemia in mice. 61
31756514 2020
21
Pharmacokinetics and pharmacodynamics analysis of XQ-1H and its combination therapy with clopidogrel on cerebral ischemic reperfusion injury in rats. 61
31735472 2020
22
Bone mesenchymal stem cell-derived exosomal microRNA-29b-3p prevents hypoxic-ischemic injury in rat brain by activating the PTEN-mediated Akt signaling pathway. 61
32014002 2020
23
KIF2 mediates the neuroprotection in cerebral ischaemia injury by affecting NF-κB pathway. 61
31514228 2020
24
Neuroprotective Effects of Selective Inhibition of Histone Deacetylase 3 in Experimental Stroke. 61
32016769 2020
25
Asiaticoside Alleviates Cerebral Ischemia-Reperfusion Injury via NOD2/Mitogen-Activated Protein Kinase (MAPK)/Nuclear Factor kappa B (NF-κB) Signaling Pathway. 61
32006420 2020
26
Involvement of PARP-1/AIF Signaling Pathway in Protective Effects of Gualou Guizhi Decoction Against Ischemia-Reperfusion Injury-Induced Apoptosis. 61
31792665 2020
27
Dendrobium Alkaloids Promote Neural Function After Cerebral Ischemia-Reperfusion Injury Through Inhibiting Pyroptosis Induced Neuronal Death in both In Vivo and In Vitro Models. 61
31865520 2020
28
miR-124-5p/NOX2 Axis Modulates the ROS Production and the Inflammatory Microenvironment to Protect Against the Cerebral I/R Injury. 61
31950451 2020
29
Increased microneedle-mediated transdermal delivery of tetramethylpyrazine to the brain, combined with borneol and iontophoresis, for MCAO prevention. 61
31857187 2020
30
Circ_016719 plays a critical role in neuron cell apoptosis induced by I/R via targeting miR-29c/Map2k6. 61
31698040 2020
31
Frequency, predictors, and outcomes of readmission to index versus non-index hospitals after mechanical thrombectomy in patients with ischemic stroke. 61
31350371 2020
32
Focal cooling of brain parenchyma in a transient large vessel occlusion model: proof-of-concept. 61
31363042 2020
33
Neuroprotective mechanism of TMP269, a selective class IIA histone deacetylase inhibitor, after cerebral ischemia/reperfusion injury. 61
31552900 2020
34
Aglaia odorata Lour. extract inhibit ischemic neuronal injury potentially via suppressing p53/Puma-mediated mitochondrial apoptosis pathway. 61
31669102 2020
35
Synthesis and Target Identification of Benzoxepane Derivatives as Potential Anti-Neuroinflammatory Agents for Ischemic Stroke. 61
31782597 2020
36
Translating intracarotid artery transplantation of bone marrow-derived NCS-01 cells for ischemic stroke: Behavioral and histological readouts and mechanistic insights into stem cell therapy. 61
31738023 2020
37
Eicosapentaenoic acid prevents inflammation induced by acute cerebral infarction through inhibition of NLRP3 inflammasome activation. 61
31830477 2020
38
An exploratory investigation of brain collateral circulation plasticity after cerebral ischemia in two experimental C57BL/6 mouse models. 61
31549895 2020
39
Neuroprotection Induced by Energy and Protein-Energy Undernutrition Is Phase-Dependent After Focal Cerebral Ischemia in Mice. 61
30887279 2020
40
Liposomal 9-Aminoacridine for Treatment of Ischemic Stroke: From Drug Discovery to Drug Delivery. 61
32039606 2020
41
Curcumin amends Ca2+ dysregulation in microglia by suppressing the activation of P2X7 receptor. 61
31894530 2020
42
Multiparametric classification of sub-acute ischemic stroke recovery with ultrafast diffusion, 23 Na, and MPIO-labeled stem cell MRI at 21.1 T. 61
31797472 2020
43
CLEC14A deficiency exacerbates neuronal loss by increasing blood-brain barrier permeability and inflammation. 61
32019570 2020
44
Activation of CRHR1 contributes to cerebral endothelial barrier impairment via cPLA2 phosphorylation in experimental ischemic stroke. 61
31715260 2020
45
let-7g counteracts endothelial dysfunction and ameliorating neurological functions in mouse ischemia/reperfusion stroke model. 61
32017988 2020
46
Collateral augmentation treatment with a combination of acetazolamide and head-down tilt in a rat ischemic stroke model. 61
32037062 2020
47
Pseudoginsenoside-F11 Accelerates Microglial Phagocytosis of Myelin Debris and Attenuates Cerebral Ischemic Injury Through Complement Receptor 3. 61
31790669 2020
48
The effect of antecedent-conditioning high-intensity interval training on BDNF regulation through PGC-1α pathway following cerebral ischemia. 61
31866362 2020
49
Real-time imaging of infarction deterioration after ischemic stroke in rats using electrical impedance tomography. 61
31918414 2020
50
Neuron-generated thrombin induces a protective astrocyte response via protease activated receptors. 61
31453648 2020
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Variations for Cerebral Artery Occlusion

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Expression for Cerebral Artery Occlusion

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Search GEO for disease gene expression data for Cerebral Artery Occlusion.
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Pathways for Cerebral Artery Occlusion

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Pathways related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
PEDF Induced Signaling 63
Show member pathways
 13.47 TNF PTGS2 NOS3 IL1RN IL1B IL16
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.17 TNF PTGS2 IL1RN IL1B IL16 HIF1A
3
Folate Metabolism 1
Show member pathways
 12.16 TNF PTGS2 IL1B APOE
4
IL-1 Family Signaling Pathways 64
Show member pathways
 12.04 TNF PTGS2 IL1RN IL1B
5
Interleukin-4 and 13 signaling 65
11.76 TNF PTGS2 IL1B HIF1A
6
Microglia Activation During Neuroinflammation: Overview 64
Show member pathways
 11.76 TNF IL1B HYAL2 ADAMTS4 ADAMTS1
7
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.64 TNF IL1RN IL1B HIF1A BDNF AQP4
8
Angiogenesis (CST) 4
11.62 PTGS2 NOS3 HIF1A ADAMTS1
9
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.61 GDNF CNTF BDNF
10
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.49 TNF PTGS2 IL1B
11
Microglia Activation During Neuroinflammation: Microglia Polarization 64
11.4 TNF PTGS2 IL1RN IL1B BDNF
12
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.31 TNF IL1B APOE
13
Interleukin-10 signaling 65
11.31 TNF PTGS2 IL1RN IL1B
14
Spinal Cord Injury 1
11.18 TNF PTGS2 IL1B GDNF BDNF AQP4
15
G-protein signaling_Rap2B regulation pathway 22
10.85 TNF IL1B IL16 EPHA3 BDNF
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GO Terms for Cerebral Artery Occlusion

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Cellular components related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.1 PTGS2 ODC1 NOS3 IL1RN IL1B IL16
2 extracellular space GO:0005615 9.65 TNF IL1RN IL1B IL16 GDNF CNTF
3 nuclear speck GO:0016607 9.55 IL16 HIF1A CYGB BDNF ADAMTS4
4 extracellular region GO:0005576 9.44 TNF IL1RN IL1B IL16 GDNF EPHA3

Biological processes related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.24 IL1RN IL1RAPL2 IL1B IL16 HIF1A GDNF
2 positive regulation of gene expression GO:0010628 10.03 TNF NOS3 IL1B HIF1A CNTF
3 negative regulation of cell proliferation GO:0008285 10.03 PTGS2 NOS3 IL1B ADM ADAMTS1
4 inflammatory response GO:0006954 10 TNF PTGS2 IL1RN IL1B ADM
5 positive regulation of cell proliferation GO:0008284 10 PTGS2 ODC1 IL1B GDNF CNTF ADM
6 response to lipopolysaccharide GO:0032496 9.88 PTGS2 NOS3 IL1B ADM
7 positive regulation of angiogenesis GO:0045766 9.88 NOS3 IL1B HIF1A ADM
8 response to organic substance GO:0010033 9.84 TNF PTGS2 ADM
9 positive regulation of inflammatory response GO:0050729 9.84 TNF IL1B HYAL2
10 positive regulation of JNK cascade GO:0046330 9.83 TNF IL1RN IL1B
11 cellular oxidant detoxification GO:0098869 9.82 PTGS2 CYGB APOE
12 positive regulation of interleukin-6 production GO:0032755 9.8 TNF IL1RN IL1B
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.74 TNF PTGS2 IL1B
14 negative regulation of MAP kinase activity GO:0043407 9.72 IL1B HYAL2 APOE
15 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.71 TNF IL1B GDNF
16 positive regulation of interleukin-6 secretion GO:2000778 9.69 TNF IL1B HYAL2
17 response to reactive oxygen species GO:0000302 9.67 HYAL2 APOE
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 TNF NOS3 IL1B
19 positive regulation of neuroinflammatory response GO:0150078 9.66 TNF IL1B
20 negative regulation of fibroblast migration GO:0010764 9.65 HYAL2 CYGB
21 positive regulation of chemokine biosynthetic process GO:0045080 9.64 TNF IL1B
22 negative regulation of platelet activation GO:0010544 9.64 NOS3 APOE
23 positive regulation of vascular endothelial growth factor production GO:0010575 9.63 PTGS2 IL1B HIF1A
24 regulation of establishment of endothelial barrier GO:1903140 9.62 TNF IL1B
25 ovulation from ovarian follicle GO:0001542 9.61 NOS3 ADAMTS1
26 positive regulation of nitric-oxide synthase activity GO:0051000 9.61 TNF HIF1A APOE
27 positive regulation of prostaglandin biosynthetic process GO:0031394 9.6 PTGS2 IL1B
28 regulation of nitric-oxide synthase activity GO:0050999 9.58 NOS3 IL1B CYGB
29 sequestering of triglyceride GO:0030730 9.56 TNF IL1B
30 response to glucocorticoid GO:0051384 9.56 TNF PTGS2 IL1RN ADM
31 negative regulation of neuron apoptotic process GO:0043524 9.55 HIF1A GDNF CNTF BDNF APOE
32 astrocyte activation GO:0048143 9.54 TNF IL1B CNTF
33 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.5 TNF IL1B APOE
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.48 TNF IL1B
35 cytokine-mediated signaling pathway GO:0019221 9.23 TNF PTGS2 IL1RN IL1RAPL2 IL1B IL16
36 positive regulation of fever generation GO:0031622 9.13 TNF PTGS2 IL1B

Molecular functions related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 TNF PTGS2 ODC1 NOS3 IL1RN IL1RAPL2
2 interleukin-1 receptor binding GO:0005149 9.16 IL1RN IL1B
3 cytokine activity GO:0005125 9.02 TNF IL1RN IL1B IL16 CNTF
Sources

Sources for Cerebral Artery Occlusion

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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