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MCID: CRB004
MIFTS: 38

Cerebral Artery Occlusion

Categories: Cardiovascular diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cerebral Artery Occlusion

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MalaCards integrated aliases for Cerebral Artery Occlusion:

Name: Cerebral Artery Occlusion 12 15

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:10127
ICD9CM 35 434 434.9
SNOMED-CT 68 20059004
UMLS 72 C0028790
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Summaries for Cerebral Artery Occlusion

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MalaCards based summary : Cerebral Artery Occlusion is related to brain injury and aphasia. An important gene associated with Cerebral Artery Occlusion is BDNF (Brain Derived Neurotrophic Factor), and among its related pathways/superpathways are Spinal Cord Injury and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Mitogens and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and endothelial, and related phenotypes are behavior/neurological and endocrine/exocrine gland

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Related Diseases for Cerebral Artery Occlusion

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Diseases related to Cerebral Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 brain injury 31.3 BDNF APOE
2 aphasia 30.8 BDNF APOE
3 alexia 30.3 AQP4 APOE
4 traumatic brain injury 29.7 BDNF AQP4 APOE
5 stroke, ischemic 29.6 GDNF AQP4 APOE
6 parkinson disease, late-onset 29.2 GDNF BDNF APOE
7 brain edema 10.7
8 hydrops, lactic acidosis, and sideroblastic anemia 10.6
9 ischemia 10.5
10 hemiplegia 10.5
11 transient cerebral ischemia 10.5
12 48,xyyy 10.4
13 hyperglycemia 10.4
14 moyamoya disease 1 10.4
15 carotid artery occlusion 10.4
16 cerebrovascular disease 10.4
17 aneurysm 10.3
18 vascular disease 10.3
19 cerebral aneurysms 10.2
20 cerebral hypoxia 10.2
21 mutism 10.2
22 mast cell activation syndrome 10.2
23 drug-induced hearing loss 10.2 GDNF BDNF
24 brachial plexus lesion 10.2 GDNF BDNF
25 head injury 10.2
26 thrombosis 10.1
27 visual epilepsy 10.1
28 retinal ischemia 10.1
29 carotid stenosis 10.1
30 akinetic mutism 10.1
31 carotid artery dissection 10.1
32 hypoxia 10.1
33 seizure disorder 10.1
34 autoimmune disease of central nervous system 10.1 BDNF AQP4
35 communicating hydrocephalus 10.1 AQP4 APOE
36 aortic disease 10.1 APOE ADAMTS1
37 wallerian degeneration 10.1 ODC1 CNTF
38 myocardial infarction 10.0
39 apraxia 10.0
40 endocarditis 10.0
41 neutropenia 10.0
42 intracranial thrombosis 10.0
43 b-cell lymphoma 10.0
44 hypoglycemia 10.0
45 neonatal stroke 10.0
46 autonomic dysfunction 10.0
47 rare surgical neurologic disease 10.0
48 post-traumatic stress disorder 10.0 BDNF APOE
49 autoimmune disease 10.0
50 huntington disease 10.0

Graphical network of the top 20 diseases related to Cerebral Artery Occlusion:



Diseases related to Cerebral Artery Occlusion
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Symptoms & Phenotypes for Cerebral Artery Occlusion

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MGI Mouse Phenotypes related to Cerebral Artery Occlusion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 ADM APOE AQP4 BDNF CNTF EPHA3
2 endocrine/exocrine gland MP:0005379 9.8 ADAMTS1 ADM APOE AQP4 BDNF GDNF
3 homeostasis/metabolism MP:0005376 9.8 ADAMTS1 ADM APOE AQP4 BDNF CNTF
4 mortality/aging MP:0010768 9.76 ADAMTS1 ADM APOE AQP4 BDNF EPHA3
5 renal/urinary system MP:0005367 9.35 ADAMTS1 ADM APOE AQP4 GDNF
6 respiratory system MP:0005388 9.02 ADM APOE AQP4 BDNF EPHA3
Sources

Drugs & Therapeutics for Cerebral Artery Occlusion

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Drugs for Cerebral Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Mitogens Phase 4
2
Clopidogrel Approved Phase 3 113665-84-2, 120202-66-6 60606
3
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
4 Analgesics Phase 3
5 Neurotransmitter Agents Phase 3
6 Analgesics, Non-Narcotic Phase 3
7 Cyclooxygenase Inhibitors Phase 3
8 Fibrinolytic Agents Phase 3
9 Anti-Inflammatory Agents, Non-Steroidal Phase 3
10 Purinergic P2Y Receptor Antagonists Phase 3
11 Peripheral Nervous System Agents Phase 3
12 Purinergic P2 Receptor Antagonists Phase 3
13 Platelet Aggregation Inhibitors Phase 3
14 Anti-Inflammatory Agents Phase 3
15 Antipyretics Phase 3
16 Antirheumatic Agents Phase 3
17 Tissue Plasminogen Activator Phase 3
18
Iron Approved, Experimental Phase 2 15438-31-0, 7439-89-6 23925 27284
19
Deferoxamine Approved, Investigational Phase 2 70-51-9 2973
20
Fibrinolysin Investigational Phase 1, Phase 2 9004-09-5
21 Siderophores Phase 2
22 Chelating Agents Phase 2
23 Iron Chelating Agents Phase 2
24 Anesthetics

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Effects of Intranasal Nerve Growth Factor for Acute Ischemic Stroke Recruiting NCT03686163 Phase 4 Nerve Growth Factors;normal saline
2 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Unknown status NCT01758614 Phase 3 Aspirin;Clopidogrel
3 Transcranial Ultrasound Enhanced Thrombolysis (TRUST) Unknown status NCT00336596 Phase 3
4 A Phase 1/2a, Open Label, Dose Escalation, Safety Study of Intra-thrombus Plasmin (Human) Administration in Acute, Middle Cerebral Artery, Ischemic Stroke Completed NCT01014975 Phase 1, Phase 2
5 Double-blind, Randomized, Placebo Controlled, Dose-finding Phase 2 Clinical Trial of Intravenous Deferoxamine in Patients With Acute Ischemic Stroke Treated With Tissue Plasminogen Activator Completed NCT00777140 Phase 2 Deferoxamine
6 Randomized Therapeutic Study Assessing the Superiority of a Sequential Intravenous Thrombolysis Treatment (Rt-PA + Tenecteplase) in Comparison With Rt-PA Standard Treatment in Proximal Middle Cerebral Artery Occlusion (DIVA). Withdrawn NCT02338466 Phase 2 rt-PA;tenecteplase
7 Remote Ischaemic Conditioning in Endovascular Recanalization for Proximal Anterior Circulation Occlusion (RICE PAC) Study Not yet recruiting NCT03152799 Phase 1
8 Incidence, Nature and Consequences of Cortical Depolarizations in Human Brain Injury From Trauma and Ischemia: The COSBID Study Unknown status NCT00258505
9 Evaluation of Clinical Results of Treatment of Cerebral Artery Occlusion by Mechanical Thrombectomy, in the Acute Phase of Stroke Completed NCT02880579
10 Remote Ischemic Preconditioning for Carotid Endarterectomy Completed NCT02808754
11 Transcranial Direct Current Stimulation (tDCS) in Acute Stroke Patients Recruiting NCT02806856
12 FRench Acute Cerebral Multimodal Imaging to Select Patient for MEchanical Thrombectomy Active, not recruiting NCT03045146
13 Benefits of the Endovascular Treatment in the Early Management of Proximal Sylvian Artery Thrombosis in Patients Refractory or Ineligible to Intravenous Fibrinolysis : a Multicenter Controled Randomized Trial Terminated NCT02216565 Alteplase if patient is eligible

Search NIH Clinical Center for Cerebral Artery Occlusion

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Genetic Tests for Cerebral Artery Occlusion

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Anatomical Context for Cerebral Artery Occlusion

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MalaCards organs/tissues related to Cerebral Artery Occlusion:

41
Brain, Bone, Endothelial, Bone Marrow, Cortex, Neutrophil, T Cells
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Publications for Cerebral Artery Occlusion

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Articles related to Cerebral Artery Occlusion:

(show top 50) (show all 10199)
# Title Authors PMID Year
1
Overexpression of the long non-coding RNA Oprm1 alleviates apoptosis from cerebral ischemia-reperfusion injury through the Oprm1/miR-155/GATA3 axis. 38
31187646 2019
2
BKCa channel is a molecular target of vitamin C to protect against ischemic brain stroke. 38
30991005 2019
3
Sirtuin 3 promotes microglia migration by upregulating CX3CR1. 38
31208274 2019
4
Paired associative stimulation improves synaptic plasticity and functional outcomes after cerebral ischemia. 38
31290455 2019
5
Role of acute-phase protein ORM in a mice model of ischemic stroke. 38
31026065 2019
6
MK-801 attenuates lesion expansion following acute brain injury in rats: a meta-analysis. 38
31290450 2019
7
High-potassium preconditioning enhances tolerance to focal cerebral ischemia-reperfusion injury through anti-apoptotic effects in male rats. 38
31240758 2019
8
Electroacupuncture ameliorates neuronal injury by Pink1/Parkin-mediated mitophagy clearance in cerebral ischemia-reperfusion. 38
31323277 2019
9
Neuroprotective effect of glycosides in Buyang Huanwu Decoction on pyroptosis following cerebral ischemia-reperfusion injury in rats. 38
31279072 2019
10
Expression of adiponectin receptors in the brain of adult zebrafish and mouse: Links with neurogenic niches and brain repair. 38
30843204 2019
11
Chrysin ameliorates cerebral ischemia/reperfusion (I/R) injury in rats by regulating the PI3K/Akt/mTOR pathway. 38
31247243 2019
12
Constraint-induced movement therapy enhances angiogenesis and neurogenesis after cerebral ischemia/reperfusion. 38
31169192 2019
13
Protective effects of leonurine against ischemic stroke in mice by activating nuclear factor erythroid 2-related factor 2 pathway. 38
31087454 2019
14
Phosphorylated mTORC1 represses autophagic-related mRNA translation in neurons exposed to ischemia-reperfusion injury. 38
31081172 2019
15
CFLAR is a critical regulator of cerebral ischaemia-reperfusion injury through regulating inflammation and endoplasmic reticulum (ER) stress. 38
31387178 2019
16
Why microglia kill neurons after neural disorders? The friendly fire hypothesis. 38
31089039 2019
17
Gastrodin Inhibits Inflammasome Through the STAT3 Signal Pathways in TNA2 Astrocytes and Reactive Astrocytes in Experimentally Induced Cerebral Ischemia in Rats. 38
31218587 2019
18
Encapsulation of tissue plasminogen activator in pH-sensitive self-assembled antioxidant nanoparticles for ischemic stroke treatment - Synergistic effect of thrombolysis and antioxidant. 38
31181394 2019
19
The effect of pyruvate on the development and progression of post-stroke depression: A new therapeutic approach. 38
31153808 2019
20
Involvement of d-amino acid oxidase in cerebral ischaemia induced by transient occlusion of the middle cerebral artery in mice. 38
31309542 2019
21
Urolithin A-activated autophagy but not mitophagy protects against ischemic neuronal injury by inhibiting ER stress in vitro and in vivo. 38
30972969 2019
22
Hispidulin exhibits neuroprotective activities against cerebral ischemia reperfusion injury through suppressing NLRP3-mediated pyroptosis. 38
31247210 2019
23
Nestorone exerts long-term neuroprotective effects against transient focal cerebral ischemia in adult male rats. 38
30244019 2019
24
Fluoxetine mitigating late-stage cognition and neurobehavior impairment induced by cerebral ischemia reperfusion injury through inhibiting ERS-mediated neurons apoptosis in the hippocampus. 38
31103751 2019
25
Ligustroflavone reduces necroptosis in rat brain after ischemic stroke through targeting RIPK1/RIPK3/MLKL pathway. 38
31055628 2019
26
MiR-130a exerts neuroprotective effects against ischemic stroke through PTEN/PI3K/AKT pathway. 38
31226635 2019
27
Delayed Galectin-3-Mediated Reprogramming of Microglia After Stroke is Protective. 38
30798442 2019
28
Canonical Wnt Pathway Maintains Blood-Brain Barrier Integrity upon Ischemic Stroke and Its Activation Ameliorates Tissue Plasminogen Activator Therapy. 38
30852795 2019
29
CPCGI confers neuroprotection by enhancing blood circulation and neurological function in cerebral ischemia/reperfusion rats. 38
31322214 2019
30
Identification of microRNAs and messenger RNAs involved in human umbilical cord mesenchymal stem cell treatment of ischemic cerebral infarction using integrated bioinformatics analysis. 38
31089061 2019
31
Early initiation of a factor Xa inhibitor can attenuate tissue repair and neurorestoration after middle cerebral artery occlusion. 38
31103522 2019
32
Preclinical concepts and results with the GABAA antagonist S44819 in a mouse model of middle cerebral artery occlusion. 38
31089046 2019
33
Preconditioning with hydrogen sulfide ameliorates cerebral ischemia/reperfusion injury in a mouse model of transient middle cerebral artery occlusion. 38
31283913 2019
34
Upregulation of miR-874-3p decreases cerebral ischemia/reperfusion injury by directly targeting BMF and BCL2L13. 38
31200256 2019
35
Molecular Insights into NR4A2(Nurr1): an Emerging Target for Neuroprotective Therapy Against Neuroinflammation and Neuronal Cell Death. 38
30684217 2019
36
Mild hypothermia alleviates diabetes aggravated cerebral ischemic injury via activating autophagy and inhibiting pyroptosis. 38
31082455 2019
37
Melatonin attenuates white matter damage after focal brain ischemia in rats by regulating the TLR4/NF-κB pathway. 38
31158461 2019
38
The role of Interleukin-33 in the modulation of splenic T-cell immune responses after experimental ischemic stroke. 38
31146104 2019
39
Transient Focal Ischemia Significantly Alters the m6A Epitranscriptomic Tagging of RNAs in the Brain. 38
31436138 2019
40
Botch protects neurons from ischemic insult by antagonizing Notch-mediated neuroinflammation. 38
31377404 2019
41
Nitrogen-doped carbon nanocages and human umbilical cord mesenchymal stem cells cooperatively inhibit neuroinflammation and protect against ischemic stroke. 38
31229624 2019
42
Change in CSF Dynamics Responsible for ICP Elevation After Ischemic Stroke in Rats: a New Mechanism for Unexplained END? 38
31418164 2019
43
Parkin-Dependent Mitophagy is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats. 38
31416289 2019
44
Clematichinenoside Facilitates Recovery of Neurological and Motor Function in Rats after Cerebral Ischemic Injury through Inhibiting Notch/NF-κB Pathway. 38
31395423 2019
45
Dual PPARα/γ agonist aleglitazar confers stroke protection in a model of mild focal brain ischemia in mice. 38
31147725 2019
46
PAI-1 but Not PAI-2 Gene Deficiency Attenuates Ischemic Brain Injury After Experimental Stroke. 38
29978354 2019
47
ZIPK mediates endothelial cell contraction through myosin light chain phosphorylation and is required for ischemic-reperfusion injury. 38
31180722 2019
48
Yangyin Tongnao granules enhance neurogenesis in the peri-infarct area and upregulate brain-derived neurotrophic factor and vascular endothelial growth factor after focal cerebral ischemic infarction in rats. 38
31006100 2019
49
Treadmill training improves neurological deficits and suppresses neuronal apoptosis in cerebral ischemic stroke rats. 38
30964064 2019
50
Sevoflurane prevents miR-181a-induced cerebral ischemia/reperfusion injury. 38
31170386 2019
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Variations for Cerebral Artery Occlusion

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Expression for Cerebral Artery Occlusion

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Search GEO for disease gene expression data for Cerebral Artery Occlusion.
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Pathways for Cerebral Artery Occlusion

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Pathways related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Spinal Cord Injury 1
11.21 GDNF BDNF AQP4
2
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 65
10.7 GDNF CNTF BDNF
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GO Terms for Cerebral Artery Occlusion

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Cellular components related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 GDNF EPHA3 CNTF BDNF APOE ADM

Biological processes related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.26 ODC1 GDNF CNTF ADM
2 peripheral nervous system development GO:0007422 9.16 GDNF BDNF
3 negative regulation of neuron apoptotic process GO:0043524 8.92 GDNF CNTF BDNF APOE

Molecular functions related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.8 GDNF CNTF BDNF
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Sources for Cerebral Artery Occlusion

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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