MCID: CRB004
MIFTS: 46

Cerebral Artery Occlusion

Categories: Cardiovascular diseases

Aliases & Classifications for Cerebral Artery Occlusion

MalaCards integrated aliases for Cerebral Artery Occlusion:

Name: Cerebral Artery Occlusion 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:10127
ICD9CM 36 434 434.9
SNOMED-CT 69 20059004
UMLS 74 C0028790

Summaries for Cerebral Artery Occlusion

MalaCards based summary : Cerebral Artery Occlusion is related to brain injury and stroke, ischemic. An important gene associated with Cerebral Artery Occlusion is BDNF (Brain Derived Neurotrophic Factor), and among its related pathways/superpathways are PEDF Induced Signaling and G-Beta Gamma Signaling. The drugs Abciximab and Fibrinolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and endothelial, and related phenotypes are cellular and behavior/neurological

Related Diseases for Cerebral Artery Occlusion

Diseases related to Cerebral Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 brain injury 31.0 APOE BDNF
2 stroke, ischemic 30.6 APOE GDNF NOS3
3 ischemia 10.8
4 brain edema 10.5
5 peripheral vascular disease 10.3
6 hypoxia 10.3
7 hyperglycemia 10.2
8 drug-induced hearing loss 10.2 BDNF GDNF
9 brain ischemia 10.2
10 depression 10.2
11 traumatic brain injury 10.2 APOE BDNF
12 intracranial vasospasm 10.2 APOE NOS3
13 brachial plexus lesion 10.1 BDNF GDNF
14 hemiplegia 10.1
15 ischemic heart disease 10.1 APOE NOS3
16 ocular dominance 10.1 BDNF NOS1
17 tetrahydrobiopterin deficiency 10.1 NOS1 NOS3
18 mutism 10.1
19 akinetic mutism 10.1
20 carotid artery dissection 10.1
21 alzheimer's disease 1 10.1 APOE NOS1
22 alzheimer disease 2 10.1 APOE NOS3
23 sexual disorder 10.1 NOS1 NOS3
24 renovascular hypertension 10.0 NOS1 NOS3
25 moyamoya disease 1 10.0
26 cerebral hemorrhage 10.0
27 endocarditis 10.0
28 wallerian degeneration 10.0 CNTF ODC1
29 nervous system disease 10.0 APOE BDNF GDNF
30 pyloric stenosis 10.0 GDNF NOS1
31 acute vascular insufficiency of intestine 9.9 GDNF MAPK1
32 insulin-like growth factor i 9.9
33 hemorrhage, intracerebral 9.9
34 neonatal stroke 9.9
35 infective endocarditis 9.9
36 thrombosis 9.9
37 pertussis 9.9
38 hypoglycemia 9.9
39 cerebral hypoxia 9.9
40 jejunoileitis 9.9 GDNF NOS1 NOS3
41 respiratory allergy 9.9 NOS1 NOS3
42 motor neuron disease 9.9 BDNF CNTF GDNF
43 aphasia 9.8 APOE BDNF
44 cerebral amyloid angiopathy, cst3-related 9.8
45 arteries, anomalies of 9.8
46 glioma susceptibility 1 9.8
47 retinoblastoma 9.8
48 neutrophil actin dysfunction 9.8
49 retinitis pigmentosa 9.8
50 sjogren syndrome 9.8

Graphical network of the top 20 diseases related to Cerebral Artery Occlusion:



Diseases related to Cerebral Artery Occlusion

Symptoms & Phenotypes for Cerebral Artery Occlusion

MGI Mouse Phenotypes related to Cerebral Artery Occlusion:

47 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.11 APOE BDNF CNTF GDNF MAPK1 NOS1
2 behavior/neurological MP:0005386 10.07 APOE BDNF CNTF GDNF MAPK1 NOS1
3 growth/size/body region MP:0005378 10 APOE BDNF GDNF MAPK1 NOS1 NOS3
4 hematopoietic system MP:0005397 9.98 APOE CNTF GDNF IL16 MAPK1 NOS1
5 digestive/alimentary MP:0005381 9.97 APOE BDNF GDNF MAPK1 NOS1 NOS3
6 endocrine/exocrine gland MP:0005379 9.95 APOE BDNF GDNF MAPK1 NOS1 NOS3
7 immune system MP:0005387 9.95 APOE CNTF GDNF IL16 MAPK1 NOS1
8 nervous system MP:0003631 9.87 APOE BDNF CNTF GDNF MAPK1 NOS1
9 muscle MP:0005369 9.85 APOE CNTF GDNF MAPK1 NOS1 NOS3
10 reproductive system MP:0005389 9.73 APOE BDNF GDNF MAPK1 NOS1 NOS3
11 respiratory system MP:0005388 9.55 APOE BDNF MAPK1 NOS1 NOS3
12 taste/olfaction MP:0005394 9.13 APOE BDNF MAPK1
13 vision/eye MP:0005391 9.02 APOE BDNF MAPK1 NOS1 NOS3

Drugs & Therapeutics for Cerebral Artery Occlusion

Drugs for Cerebral Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abciximab Approved Phase 4 143653-53-6
2 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Not Applicable
3 Tissue Plasminogen Activator Phase 4,Phase 3,Phase 2,Not Applicable
4 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2
5 Plasminogen Phase 4,Phase 2,Not Applicable
6 Anticoagulants Phase 4,Phase 2
7 Mitogens Phase 4
8
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
9
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
10 Purinergic P2Y Receptor Antagonists Phase 3
11 Antirheumatic Agents Phase 3
12 Analgesics, Non-Narcotic Phase 3
13 Analgesics Phase 3
14 Purinergic P2 Receptor Antagonists Phase 3
15 Anti-Inflammatory Agents, Non-Steroidal Phase 3
16 Antipyretics Phase 3
17 Neurotransmitter Agents Phase 3
18 Cyclooxygenase Inhibitors Phase 3
19 Anti-Inflammatory Agents Phase 3
20 Peripheral Nervous System Agents Phase 3
21
Tenecteplase Approved Phase 2 191588-94-0
22
Iron Approved, Experimental Phase 2 7439-89-6, 15438-31-0 23925 27284
23
Deferoxamine Approved, Investigational Phase 2 70-51-9 2973
24
Argatroban Approved, Investigational Phase 2 74863-84-6 152951
25
Serine Approved, Nutraceutical Phase 2 56-45-1 5951
26 Pharmaceutical Solutions Phase 2
27 Chelating Agents Phase 2
28 Iron Chelating Agents Phase 2
29 Siderophores Phase 2
30 Antithrombin III Phase 2
31 Serine Proteinase Inhibitors Phase 2
32 HIV Protease Inhibitors Phase 2
33 Antithrombins Phase 2
34
protease inhibitors Phase 2
35
Warfarin Approved 81-81-2 6691 54678486
36
Dabigatran Investigational 211914-51-1

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 A Randomized Double Blind Placebo Control Study of Huang-Chi-Wu-Wu- Tang in Patients With Intracranial Arterial Stenosis Unknown status NCT01553643 Phase 4 Chinese Herb Huang-Chi-Wu-Wu-Tang;placebo
2 Thrombectomy Under Reopro Versus Alteplase to Treat Stoke Terminated NCT02016547 Phase 4 alteplase 0.9mg/kg (10% by IV bolus following by 90% by 1 hour IV drip)
3 Effects of Intranasal Nerve Growth Factor for Acute Ischemic Stroke Recruiting NCT03686163 Phase 4 Nerve Growth Factors;normal saline
4 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Unknown status NCT01758614 Phase 3 Aspirin;Clopidogrel
5 Ultrasound Enhanced Thrombolytic Therapy of Middle Cerebral Artery Occlusion Unknown status NCT00336596 Phase 3
6 Superiority of Rt-PA + Tenecteplase in Comparison With Rt-PA Only in Proximal Middle Cerebral Artery Occlusion Withdrawn NCT02338466 Phase 2 rt-PA;tenecteplase
7 Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion Completed NCT00777140 Phase 2 Deferoxamine
8 Safety and Feasibility of Argatroban, Tissue Plasminogen Activator and Intra-arterial Therapy in Stroke Completed NCT02448069 Phase 2 Argatroban
9 Neurothrombectomy France Completed NCT02880579
10 Embolectomy in Acute SYlvian Thrombosis in Refractory or Ineligible Patients to ALteplase Terminated NCT02216565 Not Applicable Alteplase if patient is eligible
11 The Comparative Safety and Effectiveness of Warfarin and Dabigatran Prescribed in the Non-valvular Atrial Fibrillation Population With Humana Healthcare Coverage Completed NCT02061748 Observational
12 Berlin PRehospital Or Usual Delivery of Acute Stroke Care Recruiting NCT02869386 Not Applicable

Search NIH Clinical Center for Cerebral Artery Occlusion

Genetic Tests for Cerebral Artery Occlusion

Anatomical Context for Cerebral Artery Occlusion

MalaCards organs/tissues related to Cerebral Artery Occlusion:

42
Brain, Cortex, Endothelial, Bone, Spinal Cord, Thalamus, Neutrophil

Publications for Cerebral Artery Occlusion

Articles related to Cerebral Artery Occlusion:

(show top 50) (show all 1677)
# Title Authors Year
1
Using the behavioral flexibility operant task to detect long-term deficits in rats following middle cerebral artery occlusion. ( 30107224 )
2019
2
Oncostatin M-induced upregulation of SDF-1 improves Bone marrow stromal cell migration in a rat middle cerebral artery occlusion stroke model. ( 30213507 )
2019
3
'Governor vessel-unblocking and mind-regulating' acupuncture therapy ameliorates cognitive dysfunction in a rat model of middle cerebral artery occlusion. ( 30431067 )
2019
4
An enriched environment promotes synaptic plasticity and cognitive recovery after permanent middle cerebral artery occlusion in mice. ( 30539814 )
2019
5
Successful double mechanical thrombectomy in bilateral M1 middle cerebral artery occlusion. ( 30637667 )
2019
6
Bridging Therapy Versus Direct Mechanical Thrombectomy in Patients with Acute Ischemic Stroke due to Middle Cerebral Artery Occlusion: A Clinical-Histological Analysis of Retrieved Thrombi. ( 30654640 )
2019
7
Amide proton transfer-weighted MRI can detect tissue acidosis and monitor recovery in a transient middle cerebral artery occlusion model compared with a permanent occlusion model in rats. ( 30666450 )
2019
8
Increased expression of thymic stromal lymphopoietin receptor in a rat model of middle cerebral artery occlusion. ( 30676545 )
2019
9
Effects of thrombolysis within 6 hours on acute cerebral infarction in an improved rat embolic middle cerebral artery occlusion model for ischaemic stroke. ( 30697923 )
2019
10
A novel rat model of cerebral artery occlusion complicated with prior venous stagnation. ( 30703390 )
2019
11
Middle Cerebral Artery Occlusion Allowing Reperfusion via Common Carotid Artery Repair in Mice. ( 30735149 )
2019
12
Spreading depolarization and neuronal damage or survival in mouse neocortical brain slices immediately and 12 hours following middle cerebral artery occlusion. ( 30811255 )
2019
13
Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion. ( 30816157 )
2019
14
Correction to: Human adipose-derived stem cells partially rescue the stroke syndromes by promoting spatial learning and memory in mouse middle cerebral artery occlusion model. ( 30841898 )
2019
15
Development of a Novel Canine Model of Ischemic Stroke: Skull Base Approach with Transient Middle Cerebral Artery Occlusion. ( 30898757 )
2019
16
A Genome-Wide Analysis of the Penumbral Volume in Inbred Mice following Middle Cerebral Artery Occlusion. ( 30911049 )
2019
17
Identification and functional analysis of circular RNAs induced in rats by middle cerebral artery occlusion. ( 30914324 )
2019
18
Progression of vasogenic edema induced by activated microglia under permanent middle cerebral artery occlusion. ( 29353043 )
2018
19
Middle Cerebral Artery Occlusion by an Intraluminal Suture Method. ( 29222799 )
2018
20
Dietary nitrate supplementation reduces low frequency blood pressure fluctuations in rats following distal middle cerebral artery occlusion. ( 29856262 )
2018
21
Acute Right Middle Cerebral Artery Occlusion Resulting in Acute Systolic Heart Failure, Cerebral T-Waves, and QTc Prolongation: A Case Report. ( 29953038 )
2018
22
Delayed Recanalization Promotes Functional Recovery in Rats Following Permanent Middle Cerebral Artery Occlusion. ( 29354887 )
2018
23
Ginkgolide K promotes angiogenesis in a middle cerebral artery occlusion mouse model via activating JAK2/STAT3 pathway. ( 29890157 )
2018
24
Effect of laser Doppler flowmetry and occlusion time on outcome variability and mortality in rat middle cerebral artery occlusion: inconclusive results. ( 29673328 )
2018
25
Intravenously Delivered Allogeneic Mesenchymal Stem Cells Bidirectionally Regulate Inflammation and Induce Neurotrophic Effects in Distal Middle Cerebral Artery Occlusion Rats Within the First 7 Days After Stroke. ( 29719282 )
2018
26
Neuronal loss and gliosis in the rat striatum subjected to 15 and 30 minutes of middle cerebral artery occlusion. ( 29354885 )
2018
27
The degree of leukoaraiosis predicts clinical outcomes and prognosis in patients with middle cerebral artery occlusion after intravenous thrombolysis. ( 29288062 )
2018
28
Epigallocatechin-3-Gallate Reduces Neuronal Apoptosis in Rats after Middle Cerebral Artery Occlusion Injury via PI3K/AKT/eNOS Signaling Pathway. ( 29770336 )
2018
29
Ischemic Stroke Detection by Analyzing Heart Rate Variability in Rat Middle Cerebral Artery Occlusion Model. ( 29877839 )
2018
30
MicroRNA-149-5p regulates blood-brain barrier permeability after transient middle cerebral artery occlusion in rats by targeting S1PR2 of pericytes. ( 29401609 )
2018
31
Hypoxic postconditioning enhances functional recovery following endothelin-1 induced middle cerebral artery occlusion in conscious rats. ( 29778441 )
2018
32
Licorice Pretreatment Protects Against Brain Damage Induced by Middle Cerebral Artery Occlusion in Mice. ( 29341803 )
2018
33
Electroacupuncture: a new approach to open the blood-brain barrier in rats recovering from middle cerebral artery occlusion. ( 29903719 )
2018
34
Identification of Proteins Differentially Expressed by Quercetin Treatment in a Middle Cerebral Artery Occlusion Model: A Proteomics Approach. ( 29926355 )
2018
35
Bilateral Middle Cerebral Artery Occlusion In Rapid Succession During Thrombolysis. ( 29623161 )
2018
36
Long non-coding RNA RMST silencing protects against middle cerebral artery occlusion (MCAO)-induced ischemic stroke. ( 29258823 )
2018
37
Citalopram attenuated neurobehavioral, biochemical, and metabolic alterations in transient middle cerebral artery occlusion model of stroke in male Wistar rats. ( 29656429 )
2018
38
Evidence from functional ultrasound imaging of enhanced contralesional microvascular response to somatosensory stimulation in acute middle cerebral artery occlusion/reperfusion in rats: A marker of ultra-early network reorganization? ( 29972329 )
2018
39
Comparison of therapeutic efficacy between isolated encephaloduroarteriosynangiosis and medical treatment in patients with atherosclerotic middle cerebral artery occlusion. ( 29935318 )
2018
40
Tirofiban combined with rt-PA intraarterial thrombolysis improves the recanalization rate of acute middle cerebral artery occlusion in rabbits. ( 29771445 )
2018
41
Dipyridamole plus Triflusal versus Triflusal Alone in Infarct Reduction after Middle Cerebral Artery Occlusion. ( 29338983 )
2018
42
Tail Vein Infusion of Adipose-Derived Mesenchymal Stem Cell Alleviated Inflammatory Response and Improved Blood Brain Barrier Condition by Suppressing Endoplasmic Reticulum Stress in a Middle Cerebral Artery Occlusion Rat Model. ( 29888735 )
2018
43
Mechanical Thrombectomy of Acute Middle Cerebral Artery Occlusion using Trans-Anterior Communicating Artery Approach. ( 29339323 )
2018
44
Protective effects of beef decoction rich in carnosine on cerebral ischemia injury by permanent middle cerebral artery occlusion in rats. ( 29399121 )
2018
45
Targeted Temperature Management at 33A^C or 36A^C Produces Equivalent Neuroprotective Effects in the Middle Cerebral Artery Occlusion Rat Model of Ischemic Stroke. ( 29337840 )
2018
46
Repeated Endovascular Treatment of Early Recurrent Proximal Middle Cerebral Artery Occlusion: Case Report and Brief Review of the Literature. ( 29774008 )
2018
47
Predictors of short-term outcome in patients with acute middle cerebral artery occlusion: unsuitability of fluid-attenuated inversion recovery vascular hyperintensity scores. ( 29451209 )
2018
48
Ischemia Reperfusion Injury after Gradual versus Rapid Flow Restoration for Middle Cerebral Artery Occlusion Rats. ( 29374244 )
2018
49
Myricetin against ischemic cerebral injury in rat middle cerebral artery occlusion model. ( 29257250 )
2018
50
Characterization of the transient middle cerebral artery occlusion model of ischemic stroke in a HuR transgenic mouse line. ( 29854897 )
2018

Variations for Cerebral Artery Occlusion

Expression for Cerebral Artery Occlusion

Search GEO for disease gene expression data for Cerebral Artery Occlusion.

Pathways for Cerebral Artery Occlusion

Pathways related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.04 BDNF CNTF GDNF IL16 MAPK1 NOS1
2
Show member pathways
12.79 BDNF MAPK1 NOS1 NOS3
3
Show member pathways
12.33 MAPK1 NOS1 NOS3
4
Show member pathways
11.86 BDNF GDNF MAPK1
5 11.75 MAPK1 NOS1 NOS3
7 11.34 MAPK1 NOS3
8 11.33 BDNF CNTF GDNF
9 11.26 APOE MAPK1
10
Show member pathways
11.22 NOS1 NOS3
11
Show member pathways
11.19 NOS1 NOS3
12 11.16 GDNF MAPK1
13 11.1 BDNF MAPK1
14 11.09 MAPK1 NOS3
15 11 BDNF GDNF MAPK1 NOS1
16 10.99 MAPK1 NOS1
17 10.98 NOS1 NOS3
18 10.96 BDNF MAPK1
19
Show member pathways
10.93 NOS1 NOS3
20
Show member pathways
10.89 NOS1 NOS3 ODC1
21 10.87 MAPK1 NOS3
22 10.86 NOS1 NOS3
23 10.55 BDNF MAPK1
24 10.48 NOS1 NOS3
25 10.22 NOS1 NOS3

GO Terms for Cerebral Artery Occlusion

Cellular components related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.86 APOE BDNF CNTF IL16 MAPK1 NOS1
2 extracellular region GO:0005576 9.43 APOE BDNF CNTF GDNF IL16 MAPK1
3 vesicle membrane GO:0012506 9.16 NOS1 NOS3
4 caveola GO:0005901 8.8 MAPK1 NOS1 NOS3

Biological processes related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.84 CNTF GDNF MAPK1 ODC1
2 regulation of signaling receptor activity GO:0010469 9.8 BDNF CNTF GDNF IL16
3 regulation of gene expression GO:0010468 9.75 APOE GDNF MAPK1
4 axon guidance GO:0007411 9.72 BDNF GDNF MAPK1
5 response to lipopolysaccharide GO:0032496 9.7 MAPK1 NOS1 NOS3
6 response to heat GO:0009408 9.59 NOS1 NOS3
7 lipopolysaccharide-mediated signaling pathway GO:0031663 9.58 MAPK1 NOS3
8 negative regulation of blood pressure GO:0045776 9.57 NOS1 NOS3
9 peripheral nervous system development GO:0007422 9.56 BDNF GDNF
10 regulation of sodium ion transport GO:0002028 9.51 NOS1 NOS3
11 negative regulation of calcium ion transport GO:0051926 9.48 NOS1 NOS3
12 nitric oxide biosynthetic process GO:0006809 9.46 NOS1 NOS3
13 negative regulation of neuron apoptotic process GO:0043524 9.46 APOE BDNF CNTF GDNF
14 negative regulation of potassium ion transport GO:0043267 9.43 NOS1 NOS3
15 positive regulation of guanylate cyclase activity GO:0031284 9.4 NOS1 NOS3
16 negative regulation of platelet activation GO:0010544 9.37 APOE NOS3
17 arginine catabolic process GO:0006527 9.32 NOS1 NOS3
18 negative regulation of hydrolase activity GO:0051346 9.26 NOS1 NOS3
19 vasodilation GO:0042311 9.13 APOE NOS1 NOS3
20 nitric oxide mediated signal transduction GO:0007263 8.8 APOE NOS1 NOS3

Molecular functions related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.58 BDNF CNTF GDNF
2 NADP binding GO:0050661 9.43 NOS1 NOS3
3 FMN binding GO:0010181 9.37 NOS1 NOS3
4 arginine binding GO:0034618 9.32 NOS1 NOS3
5 NADPH-hemoprotein reductase activity GO:0003958 9.26 NOS1 NOS3
6 cadmium ion binding GO:0046870 9.16 NOS1 NOS3
7 tetrahydrobiopterin binding GO:0034617 8.96 NOS1 NOS3
8 nitric-oxide synthase activity GO:0004517 8.62 NOS1 NOS3

Sources for Cerebral Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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