MCID: CRB004
MIFTS: 45

Cerebral Artery Occlusion

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Cerebral Artery Occlusion

MalaCards integrated aliases for Cerebral Artery Occlusion:

Name: Cerebral Artery Occlusion 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:10127
ICD9CM 34 434 434.9
SNOMED-CT 67 20059004
UMLS 71 C0028790

Summaries for Cerebral Artery Occlusion

MalaCards based summary : Cerebral Artery Occlusion is related to brain injury and brain edema. An important gene associated with Cerebral Artery Occlusion is BDNF (Brain Derived Neurotrophic Factor), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. The drugs Labetalol and Nicardipine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and endothelial, and related phenotypes are homeostasis/metabolism and behavior/neurological

Related Diseases for Cerebral Artery Occlusion

Diseases related to Cerebral Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 287)
# Related Disease Score Top Affiliating Genes
1 brain injury 31.4 BDNF AQP4 APOE
2 brain edema 31.0 IL1RN IL1B AQP4
3 carotid stenosis 30.7 TNF NOS3 APOE
4 ischemia 30.7 NOS3 IL1RN HIF1A BDNF
5 traumatic brain injury 30.5 BDNF AQP4 APOE
6 retinal ischemia 30.3 TNF HIF1A CNTF BDNF
7 intracranial aneurysm 30.1 TNF NOS3 APOE
8 vascular dementia 30.1 TNF IL1B APOE
9 meningitis 29.9 TNF IL1B GDNF AQP4
10 atherosclerosis susceptibility 29.9 TNF NOS3 IL1B APOE
11 stroke, ischemic 29.9 NOS3 GDNF BDNF AQP4 APOE ADM
12 narcolepsy 29.8 TNF GDNF BDNF AQP4 APOE
13 migraine with or without aura 1 29.4 TNF PTGS2 NOS3 IL1B BDNF ADM
14 hydrocephalus 29.4 TNF GDNF CNTF BDNF AQP4 APOE
15 coronary artery anomaly 29.3 TNF NOS3 IL1RN IL1B ADM
16 diabetes mellitus 28.9 TNF PTGS2 NOS3 IL1RN IL1B BDNF
17 myocardial infarction 28.6 TNF PTGS2 NOS3 IL1RN IL1B HIF1A
18 alzheimer disease 28.5 TNF PTGS2 NOS3 IL1B GDNF CNTF
19 autoimmune disease 28.2 TNF IL1RN IL1RAPL2 IL1B IL16 AQP4
20 diabetes mellitus, noninsulin-dependent 28.1 TNF PTGS2 NOS3 IL1RN IL1B CNTF
21 hydrops, lactic acidosis, and sideroblastic anemia 10.6
22 hemiplegia 10.5
23 staphylococcal toxic shock syndrome 10.5 TNF IL1B
24 mesial temporal lobe epilepsy with hippocampal sclerosis 10.5 IL1B APOE
25 transient cerebral ischemia 10.5
26 jejunoileitis 10.5 TNF GDNF
27 palladium allergic contact dermatitis 10.4 TNF IL1B
28 kashin-beck disease 10.4 TNF IL1B
29 moyamoya disease 1 10.4
30 carotid artery occlusion 10.4
31 aphasia 10.4
32 hyperglycemia 10.4
33 meningoencephalitis 10.4 TNF GDNF BDNF
34 cerebrovascular disease 10.4
35 48,xyyy 10.4
36 apnea, obstructive sleep 10.4 TNF NOS3 APOE
37 congenital cytomegalovirus 10.4 TNF IL1B
38 dry eye syndrome 10.4 TNF GDNF BDNF
39 endometrial disease 10.3 TNF PTGS2 IL1B
40 viral encephalitis 10.3 TNF PTGS2 IL1B
41 peripheral artery disease 10.3 TNF NOS3 APOE
42 primary progressive multiple sclerosis 10.3 TNF BDNF APOE
43 lumbosacral plexus lesion 10.3 CNTF BDNF
44 actinic prurigo 10.3 TNF IL1B
45 autoimmune optic neuritis 10.3 CNTF AQP4
46 limb ischemia 10.3 TNF NOS3 HIF1A
47 age-related hearing loss 10.3 HIF1A APOE
48 intracranial hypertension 10.3 TNF IL1B AQP4
49 retinal vascular disease 10.3 TNF NOS3 IL1B
50 vascular disease 10.3

Graphical network of the top 20 diseases related to Cerebral Artery Occlusion:



Diseases related to Cerebral Artery Occlusion

Symptoms & Phenotypes for Cerebral Artery Occlusion

MGI Mouse Phenotypes related to Cerebral Artery Occlusion:

45 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.37 ADAMTS1 ADM APOE AQP4 BDNF CNTF
2 behavior/neurological MP:0005386 10.35 ADAMTS4 ADM APOE AQP4 BDNF CNTF
3 cardiovascular system MP:0005385 10.35 ADM APOE AQP4 CYGB EPHA3 GDNF
4 cellular MP:0005384 10.34 ADM APOE BDNF CNTF CYGB GDNF
5 growth/size/body region MP:0005378 10.34 ADAMTS1 APOE AQP4 BDNF GDNF HIF1A
6 mortality/aging MP:0010768 10.34 ADAMTS1 ADAMTS4 ADM APOE AQP4 BDNF
7 hematopoietic system MP:0005397 10.32 ADM APOE AQP4 CNTF GDNF HIF1A
8 endocrine/exocrine gland MP:0005379 10.31 ADAMTS1 ADM APOE AQP4 BDNF CNTF
9 immune system MP:0005387 10.29 ADM APOE AQP4 CNTF GDNF HIF1A
10 digestive/alimentary MP:0005381 10.15 APOE AQP4 BDNF GDNF HIF1A NOS3
11 liver/biliary system MP:0005370 10.11 ADM APOE CYGB EPHA3 HIF1A HYAL2
12 nervous system MP:0003631 10.11 ADAMTS4 APOE AQP4 BDNF CNTF GDNF
13 muscle MP:0005369 10.06 ADM APOE CNTF CYGB GDNF HIF1A
14 renal/urinary system MP:0005367 10 ADAMTS1 ADAMTS4 ADM APOE AQP4 CYGB
15 no phenotypic analysis MP:0003012 9.92 ADAMTS4 APOE AQP4 BDNF CNTF HYAL2
16 reproductive system MP:0005389 9.9 ADAMTS1 ADM APOE BDNF CNTF CYGB
17 respiratory system MP:0005388 9.61 ADM APOE AQP4 BDNF EPHA3 HIF1A
18 skeleton MP:0005390 9.28 ADAMTS4 APOE HIF1A HYAL2 IL1B IL1RN

Drugs & Therapeutics for Cerebral Artery Occlusion

Drugs for Cerebral Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Labetalol Approved Phase 4 36894-69-6 3869
2
Nicardipine Approved, Investigational Phase 4 55985-32-5 4474
3
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
4 Mitogens Phase 4
5 Neurotransmitter Agents Phase 4
6 Adrenergic Antagonists Phase 4
7 Sympathomimetics Phase 4
8 Hormones Phase 4
9 Adrenergic beta-Antagonists Phase 4
10 Adrenergic alpha-Antagonists Phase 4
11 Vasodilator Agents Phase 4
12 Autonomic Agents Phase 4
13 Adrenergic Agents Phase 4
14 Calcium, Dietary Phase 4
15 calcium channel blockers Phase 4
16 Antihypertensive Agents Phase 4
17
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
18
Clopidogrel Approved Phase 3 113665-84-2, 120202-66-6 60606
19 Fibrinolytic Agents Phase 3
20 Tissue Plasminogen Activator Phase 3
21 Platelet Aggregation Inhibitors Phase 3
22 Antipyretics Phase 3
23 Analgesics, Non-Narcotic Phase 3
24 Analgesics Phase 3
25 Anti-Inflammatory Agents, Non-Steroidal Phase 3
26 Cyclooxygenase Inhibitors Phase 3
27 Purinergic P2Y Receptor Antagonists Phase 3
28 Antirheumatic Agents Phase 3
29 Anti-Inflammatory Agents Phase 3
30
Deferoxamine Approved, Investigational Phase 2 70-51-9 2973
31
Iron Approved, Experimental Phase 2 7439-89-6, 15438-31-0 23925 27284
32
Fibrinolysin Investigational Phase 1, Phase 2 9004-09-5
33 Siderophores Phase 2
34 Iron Chelating Agents Phase 2
35 Chelating Agents Phase 2
36 Anesthetics

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Effects of Intranasal Nerve Growth Factor for Acute Ischemic Stroke Recruiting NCT03686163 Phase 4 Nerve Growth Factors;normal saline
2 Outcome in Patients Treated With Intraarterial Thrombectomy - optiMAL Blood Pressure Control (OPTIMAL-BP) Not yet recruiting NCT04205305 Phase 4 conventional blood pressure control (labetalol, nicardipine);intensive blood pressure control (labetalol, nicardipine)
3 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Unknown status NCT01758614 Phase 3 Aspirin;Clopidogrel
4 Transcranial Ultrasound Enhanced Thrombolysis (TRUST) Unknown status NCT00336596 Phase 3
5 A Phase 1/2a, Open Label, Dose Escalation, Safety Study of Intra-thrombus Plasmin (Human) Administration in Acute, Middle Cerebral Artery, Ischemic Stroke Completed NCT01014975 Phase 1, Phase 2
6 Double-blind, Randomized, Placebo Controlled, Dose-finding Phase 2 Clinical Trial of Intravenous Deferoxamine in Patients With Acute Ischemic Stroke Treated With Tissue Plasminogen Activator Completed NCT00777140 Phase 2 Deferoxamine
7 Randomized Therapeutic Study Assessing the Superiority of a Sequential Intravenous Thrombolysis Treatment (Rt-PA + Tenecteplase) in Comparison With Rt-PA Standard Treatment in Proximal Middle Cerebral Artery Occlusion (DIVA). Withdrawn NCT02338466 Phase 2 rt-PA;tenecteplase
8 Remote Ischaemic Conditioning in Endovascular Recanalization for Proximal Anterior Circulation Occlusion (RICE PAC) Study Not yet recruiting NCT03152799 Phase 1
9 Incidence, Nature and Consequences of Cortical Depolarizations in Human Brain Injury From Trauma and Ischemia: The COSBID Study Unknown status NCT00258505
10 Transcranial Direct Current Stimulation (tDCS) in Acute Stroke Patients Unknown status NCT02806856
11 Evaluation of Clinical Results of Treatment of Cerebral Artery Occlusion by Mechanical Thrombectomy, in the Acute Phase of Stroke Completed NCT02880579
12 FRench Acute Cerebral Multimodal Imaging to Select Patient for MEchanical Thrombectomy Completed NCT03045146
13 Remote Ischemic Preconditioning for Carotid Endarterectomy Completed NCT02808754
14 Benefits of the Endovascular Treatment in the Early Management of Proximal Sylvian Artery Thrombosis in Patients Refractory or Ineligible to Intravenous Fibrinolysis : a Multicenter Controled Randomized Trial Terminated NCT02216565 Alteplase if patient is eligible

Search NIH Clinical Center for Cerebral Artery Occlusion

Genetic Tests for Cerebral Artery Occlusion

Anatomical Context for Cerebral Artery Occlusion

MalaCards organs/tissues related to Cerebral Artery Occlusion:

40
Brain, Bone, Endothelial, Bone Marrow, Cortex, Neutrophil, T Cells

Publications for Cerebral Artery Occlusion

Articles related to Cerebral Artery Occlusion:

(show top 50) (show all 10476)
# Title Authors PMID Year
1
XingNaoJing injection ameliorates cerebral ischaemia/reperfusion injury via SIRT1-mediated inflammatory response inhibition. 61
31854225 2020
2
Modified constraint-induced movement therapy alters synaptic plasticity of rat contralateral hippocampus following middle cerebral artery occlusion. 61
31823884 2020
3
Achyranthes bidentata polypeptides prevent apoptosis by inhibiting the glutamate current in cultured hippocampal neurons. 61
31823889 2020
4
Selective brain hypothermia-induced neuroprotection against focal cerebral ischemia/reperfusion injury is associated with Fis1 inhibition. 61
31719256 2020
5
Upregulated microRNA-31 inhibits oxidative stress-induced neuronal injury through the JAK/STAT3 pathway by binding to PKD1 in mice with ischemic stroke. 61
31517390 2020
6
Neuroprotection of Cyperus esculentus L. orientin against cerebral ischemia/reperfusion induced brain injury. 61
31571667 2020
7
JNK-IN-8, a c-Jun N-terminal kinase inhibitor, improves functional recovery through suppressing neuroinflammation in ischemic stroke. 61
31541462 2020
8
Aglaia odorata Lour. extract inhibit ischemic neuronal injury potentially via suppressing p53/Puma-mediated mitochondrial apoptosis pathway. 61
31669102 2020
9
Neuroprotective mechanism of TMP269, a selective class IIA histone deacetylase inhibitor, after cerebral ischemia/reperfusion injury. 61
31552900 2020
10
Neuron-generated thrombin induces a protective astrocyte response via protease activated receptors. 61
31453648 2020
11
KIF2 mediates the neuroprotection in cerebral ischaemia injury by affecting NF-κB pathway. 61
31514228 2020
12
Electroacupuncture protects rats from ischemic brain injury via coffilin in mice. 61
31599049 2020
13
MST4 modulates the neuro-inflammatory response by regulating IκBα signaling pathway and affects the early outcome of experimental ischemic stroke in mice. 61
31722252 2020
14
Neuronal loss without amyloid-β deposits in the thalamus and hippocampus in the late period after middle cerebral artery occlusion in cynomolgus monkeys. 61
31278793 2020
15
Crotalus atrox disintegrin reduces hemorrhagic transformation by attenuating matrix metalloproteinase-9 activity after middle cerebral artery occlusion in hyperglycemic male rats. 61
30242872 2020
16
Selective activation of estrogen receptor β alleviates cerebral ischemia neuroinflammatory injury. 61
31676226 2020
17
Vitronectin mitigates stroke-increased neurogenesis only in female mice and through FAK-regulated IL-6. 61
31678139 2020
18
Attenuation of secondary damage and Aβ deposits in the ipsilateral thalamus of dMCAO rats through reduction of cathepsin B by bis(propyl)-cognitin, a multifunctional dimer. 61
31726074 2020
19
Acrolein is involved in ischemic stroke-induced neurotoxicity through spermidine/spermine-N1-acetyltransferase activation. 61
31629858 2020
20
Glimepiride and glibenclamide have comparable efficacy in treating acute ischemic stroke in mice. 61
31704276 2020
21
Pharmacokinetics, pharmacodynamics and toxicity of Baicalin liposome on cerebral ischemia reperfusion injury rats via intranasal administration. 61
31605698 2020
22
Deletion of Chitinase-3-like 1 accelerates stroke development through enhancement of Neuroinflammation by STAT6-dependent M2 microglial inactivation in Chitinase-3-like 1 knockout mice. 61
31669069 2020
23
Early acid/base and electrolyte changes in permanent middle cerebral artery occlusion: Aged male and female rats. 61
30942522 2020
24
Effect of ischemic lesions in medial prefrontal cortex and nucleus accumbens on affective behavior in rats. 61
31521735 2020
25
Chloroquine pretreatment attenuates ischemia-reperfusion injury in the brain of ob/ob diabetic mice as well as wildtype mice. 61
31647899 2020
26
Effects of dietary 5-methoxyindole-2-carboxylic acid on brain functional recovery after ischemic stroke. 61
31629836 2020
27
Protective effects of Corbrin Capsule against permanent cerebral ischemia in mice. 61
31739162 2020
28
Involvement of caveolin-1 in neurovascular unit remodeling after stroke: Effects on neovascularization and astrogliosis. 61
30354902 2020
29
Molecular switching from ubiquitin-proteasome to autophagy pathways in mice stroke model. 61
30375939 2020
30
Improvement in mitochondrial function underlies the effects of ANNAO tablets on attenuating cerebral ischemia-reperfusion injuries. 61
31494200 2020
31
Activation of G protein-coupled receptor 30 protects neurons by regulating autophagy in astrocytes. 61
31429156 2020
32
Longitudinal tracing of white matter integrity on diffusion tensor imaging in the chronic cerebral ischemia and acute cerebral ischemia. 61
31715314 2020
33
Ginsenoside Rb1 Promotes Motor Functional Recovery and Axonal Regeneration in Post-stroke Mice through cAMP/PKA/CREB Signaling Pathway. 61
31715311 2020
34
Roles of GluN2C in cerebral ischemia: GluN2C expressed in different cell types plays different role in ischemic damage. 61
31820502 2019
35
Protective effects of polygalasaponin F on oxidative stress and apoptosis-induced ischemic myocardial injury in neonatal rats with hypoxic-ischemic brain damage. 61
31609825 2019
36
A likely protective effect of dimethyl itaconate on cerebral ischemia/reperfusion injury. 61
31678864 2019
37
Sirtuin 3 promotes microglia migration by upregulating CX3CR1. 61
31208274 2019
38
RNPS1 inhibition aggravates ischemic brain injury and promotes neuronal death. 61
31831174 2019
39
"Energy-sensing pathways in ischemia: The counterbalance between AMPK and mTORC". 61
31820693 2019
40
Regulatory effects associated with changes in intracellular potassium level in susceptibility to mitochondrial depolarization and excitotoxicity. 61
31805298 2019
41
Increased Mortality and Vascular Phenotype in a Knock-In Mouse Model of Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations. 61
31805844 2019
42
Reduced Apoptotic Injury by Phenothiazine in Ischemic Stroke through the NOX-Akt/PKC Pathway. 61
31847503 2019
43
Wnt canonical pathway activator TWS119 drives microglial anti-inflammatory activation and facilitates neurological recovery following experimental stroke. 61
31810470 2019
44
Rosiglitazone ameliorates tissue plasminogen activator-induced brain hemorrhage after stroke. 61
31756041 2019
45
Statin Therapy in Ischemic Stroke Models: A Meta-Analysis. 61
31788761 2019
46
The Beneficial Effects of Raffinee in Permanent Occulted Stroke Mice. 61
31545135 2019
47
Mechanical Thrombectomy for Middle Cerebral Artery Occlusion Suspected of Ovarian Hyperstimulation Syndrome: Case Report and Review of the Literature. 61
31525479 2019
48
TRPP2 associates with STIM1 to regulate cerebral vasoconstriction and enhance high salt intake-induced hypertensive cerebrovascular spasm. 61
31541223 2019
49
Effect of Recanalization on Cerebral Edema in Ischemic Stroke Treated With Thrombolysis and/or Endovascular Therapy. 61
31818228 2019
50
Found in translation: The rationale behind the early development of glibenclamide in large hemispheric infarction. 61
31805373 2019

Variations for Cerebral Artery Occlusion

Expression for Cerebral Artery Occlusion

Search GEO for disease gene expression data for Cerebral Artery Occlusion.

Pathways for Cerebral Artery Occlusion

Pathways related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.47 TNF PTGS2 NOS3 IL1RN IL1B IL16
2
Show member pathways
13.17 TNF PTGS2 IL1RN IL1B IL16 HIF1A
3
Show member pathways
12.16 TNF PTGS2 IL1B APOE
4
Show member pathways
12.04 TNF PTGS2 IL1RN IL1B
5 11.76 TNF PTGS2 IL1B HIF1A
6
Show member pathways
11.76 TNF IL1B HYAL2 ADAMTS4 ADAMTS1
7 11.64 TNF IL1RN IL1B HIF1A BDNF AQP4
8 11.62 PTGS2 NOS3 HIF1A ADAMTS1
9 11.61 GDNF CNTF BDNF
10
Show member pathways
11.49 TNF PTGS2 IL1B
11 11.4 TNF PTGS2 IL1RN IL1B BDNF
12 11.31 TNF IL1B APOE
13 11.31 TNF PTGS2 IL1RN IL1B
14 11.18 TNF PTGS2 IL1B GDNF BDNF AQP4
15 10.85 TNF IL1B IL16 EPHA3 BDNF

GO Terms for Cerebral Artery Occlusion

Cellular components related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.1 PTGS2 ODC1 NOS3 IL1RN IL1B IL16
2 extracellular space GO:0005615 9.65 TNF IL1RN IL1B IL16 GDNF CNTF
3 nuclear speck GO:0016607 9.55 IL16 HIF1A CYGB BDNF ADAMTS4
4 extracellular region GO:0005576 9.44 TNF IL1RN IL1B IL16 GDNF EPHA3

Biological processes related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.24 IL1RN IL1RAPL2 IL1B IL16 HIF1A GDNF
2 positive regulation of gene expression GO:0010628 10.03 TNF NOS3 IL1B HIF1A CNTF
3 negative regulation of cell proliferation GO:0008285 10.03 PTGS2 NOS3 IL1B ADM ADAMTS1
4 inflammatory response GO:0006954 10 TNF PTGS2 IL1RN IL1B ADM
5 positive regulation of cell proliferation GO:0008284 10 PTGS2 ODC1 IL1B GDNF CNTF ADM
6 response to lipopolysaccharide GO:0032496 9.88 PTGS2 NOS3 IL1B ADM
7 positive regulation of angiogenesis GO:0045766 9.88 NOS3 IL1B HIF1A ADM
8 response to organic substance GO:0010033 9.84 TNF PTGS2 ADM
9 positive regulation of inflammatory response GO:0050729 9.84 TNF IL1B HYAL2
10 positive regulation of JNK cascade GO:0046330 9.83 TNF IL1RN IL1B
11 cellular oxidant detoxification GO:0098869 9.82 PTGS2 CYGB APOE
12 positive regulation of interleukin-6 production GO:0032755 9.8 TNF IL1RN IL1B
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.74 TNF PTGS2 IL1B
14 negative regulation of MAP kinase activity GO:0043407 9.72 IL1B HYAL2 APOE
15 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.71 TNF IL1B GDNF
16 positive regulation of interleukin-6 secretion GO:2000778 9.69 TNF IL1B HYAL2
17 response to reactive oxygen species GO:0000302 9.67 HYAL2 APOE
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 TNF NOS3 IL1B
19 positive regulation of neuroinflammatory response GO:0150078 9.66 TNF IL1B
20 negative regulation of fibroblast migration GO:0010764 9.65 HYAL2 CYGB
21 positive regulation of chemokine biosynthetic process GO:0045080 9.64 TNF IL1B
22 negative regulation of platelet activation GO:0010544 9.64 NOS3 APOE
23 positive regulation of vascular endothelial growth factor production GO:0010575 9.63 PTGS2 IL1B HIF1A
24 regulation of establishment of endothelial barrier GO:1903140 9.62 TNF IL1B
25 ovulation from ovarian follicle GO:0001542 9.61 NOS3 ADAMTS1
26 positive regulation of nitric-oxide synthase activity GO:0051000 9.61 TNF HIF1A APOE
27 positive regulation of prostaglandin biosynthetic process GO:0031394 9.6 PTGS2 IL1B
28 regulation of nitric-oxide synthase activity GO:0050999 9.58 NOS3 IL1B CYGB
29 sequestering of triglyceride GO:0030730 9.56 TNF IL1B
30 response to glucocorticoid GO:0051384 9.56 TNF PTGS2 IL1RN ADM
31 negative regulation of neuron apoptotic process GO:0043524 9.55 HIF1A GDNF CNTF BDNF APOE
32 astrocyte activation GO:0048143 9.54 TNF IL1B CNTF
33 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.5 TNF IL1B APOE
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.48 TNF IL1B
35 cytokine-mediated signaling pathway GO:0019221 9.23 TNF PTGS2 IL1RN IL1RAPL2 IL1B IL16
36 positive regulation of fever generation GO:0031622 9.13 TNF PTGS2 IL1B

Molecular functions related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 TNF PTGS2 ODC1 NOS3 IL1RN IL1RAPL2
2 interleukin-1 receptor binding GO:0005149 9.16 IL1RN IL1B
3 cytokine activity GO:0005125 9.02 TNF IL1RN IL1B IL16 CNTF

Sources for Cerebral Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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