MCID: CRB004
MIFTS: 45

Cerebral Artery Occlusion

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Cerebral Artery Occlusion

MalaCards integrated aliases for Cerebral Artery Occlusion:

Name: Cerebral Artery Occlusion 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:10127
ICD9CM 34 434
SNOMED-CT 67 20059004
UMLS 71 C0028790

Summaries for Cerebral Artery Occlusion

MalaCards based summary : Cerebral Artery Occlusion is related to brain edema and carotid stenosis. An important gene associated with Cerebral Artery Occlusion is BDNF (Brain Derived Neurotrophic Factor), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. The drugs Nicardipine and Labetalol have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and endothelial, and related phenotypes are homeostasis/metabolism and growth/size/body region

Related Diseases for Cerebral Artery Occlusion

Diseases related to Cerebral Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 301)
# Related Disease Score Top Affiliating Genes
1 brain edema 31.2 NOS2 IL1B AQP4
2 carotid stenosis 30.7 TNF NOS3 APOE
3 encephalomalacia 30.6 TNF IL1B BDNF
4 traumatic brain injury 30.5 BDNF AQP4 APOE
5 arteriovenous malformation 30.4 TNF IL1B APOE
6 aphasia 30.3 PLG BDNF APOE
7 retinal ischemia 30.3 TNF IL1B HIF1A CNTF BDNF
8 sleep disorder 30.1 TNF IL1B BDNF APOE
9 meningitis 30.1 TNF IL1B GDNF AQP4
10 intracranial aneurysm 30.0 TNF NOS3 APOE
11 atherosclerosis susceptibility 30.0 TNF NOS3 IL1B APOE
12 carotid artery occlusion 30.0 TSPAN33 PLG NOS3 IL1B
13 congestive heart failure 29.9 TNF NOS3 IL1B ADM
14 narcolepsy 29.8 TNF IL1B BDNF AQP4 APOE
15 hydrocephalus 29.8 TNF GDNF BDNF AQP4 APOE
16 sleep apnea 29.6 TNF NOS3 IL1B HIF1A BDNF APOE
17 vascular disease 29.4 TNF PTGS2 PLG NOS3 NOS2 APOE
18 basilar artery occlusion 29.3 TSPAN33 PLG
19 microvascular complications of diabetes 5 29.3 PLG NOS3 NOS2 HIF1A
20 diabetes mellitus 29.2 TNF PTGS2 NOS3 NOS2 IL1B BDNF
21 cerebral arterial disease 29.2 TSPAN33 PLG NOS3
22 arteries, anomalies of 29.1 TNF PLG NOS3 IL1B APOE
23 lipoprotein quantitative trait locus 28.8 TNF PLG NOS3 IL1B HIF1A ADM
24 retinitis pigmentosa 28.5 TNF IL1B HIF1A GDNF CYGB CNTF
25 myocardial infarction 28.4 TNF PTGS2 PLG NOS3 IL1B HIF1A
26 alzheimer disease 28.4 TNF PTGS2 NOS3 NOS2 IL1B GDNF
27 migraine with or without aura 1 28.0 TNF PTGS2 PLG NOS3 IL1B BDNF
28 stroke, ischemic 27.9 TSPAN33 TNF PLG NOS3 IL1B GDNF
29 diabetes mellitus, noninsulin-dependent 27.6 TNF PTGS2 PLG NOS3 IL1B HIF1A
30 physiological polycythemia 10.6 TNF IL1B
31 systemic onset juvenile idiopathic arthritis 10.5 TNF IL1B
32 staphylococcal toxic shock syndrome 10.5 TNF IL1B
33 vulvar vestibulitis syndrome 10.5 TNF IL1B
34 brain injury 10.5
35 palladium allergic contact dermatitis 10.5 TNF IL1B
36 mesial temporal lobe epilepsy with hippocampal sclerosis 10.5 IL1B APOE
37 kashin-beck disease 10.5 TNF IL1B
38 ischemia 10.5
39 platelet membrane fluidity 10.5 NOS3 NOS2
40 hemiplegia 10.5
41 transient cerebral ischemia 10.5
42 inflammatory bowel disease 25 10.5 TNF PTGS2
43 spotted fever rickettsiosis 10.4 TNF NOS2
44 diabetic encephalopathy 10.4 IL1B GDNF BDNF
45 jejunoileitis 10.4 TNF IL1B GDNF
46 lumbosacral lipoma 10.4 TNF IL1B HIF1A
47 cerebrovascular disease 10.4
48 somatoform disorder 10.4 TNF IL1B BDNF
49 moyamoya disease 1 10.4
50 ectodermal dysplasia 1, hypohidrotic, x-linked 10.4 TNF IL1B BDNF

Graphical network of the top 20 diseases related to Cerebral Artery Occlusion:



Diseases related to Cerebral Artery Occlusion

Symptoms & Phenotypes for Cerebral Artery Occlusion

MGI Mouse Phenotypes related to Cerebral Artery Occlusion:

45 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.43 ADAMTS1 ADM APOE AQP4 BDNF CNTF
2 growth/size/body region MP:0005378 10.42 ADAMTS1 ADAMTS4 APOE AQP4 BDNF GDNF
3 behavior/neurological MP:0005386 10.4 ADAMTS4 ADM APOE AQP4 BDNF CNTF
4 cardiovascular system MP:0005385 10.4 ADM APOE AQP4 CYGB EPHA3 GDNF
5 endocrine/exocrine gland MP:0005379 10.4 ADAMTS1 ADM APOE AQP4 BDNF CNTF
6 cellular MP:0005384 10.39 ADM APOE BDNF CNTF CYGB GDNF
7 mortality/aging MP:0010768 10.39 ADAMTS1 ADAMTS4 ADM APOE AQP4 BDNF
8 hematopoietic system MP:0005397 10.38 ADM APOE AQP4 CNTF GDNF HIF1A
9 immune system MP:0005387 10.36 ADM APOE AQP4 CNTF GDNF HIF1A
10 digestive/alimentary MP:0005381 10.27 APOE AQP4 BDNF GDNF HIF1A NOS2
11 liver/biliary system MP:0005370 10.22 ADM APOE CYGB EPHA3 HIF1A HYAL2
12 nervous system MP:0003631 10.18 ADAMTS4 APOE AQP4 BDNF CNTF GDNF
13 integument MP:0010771 10.15 ADM APOE BDNF HIF1A IL1B NOS2
14 adipose tissue MP:0005375 10.14 ADAMTS1 APOE NOS2 NOS3 ODC1 PTGS2
15 muscle MP:0005369 10.13 ADM APOE CNTF CYGB GDNF HIF1A
16 renal/urinary system MP:0005367 10.07 ADAMTS1 ADAMTS4 ADM APOE AQP4 CYGB
17 neoplasm MP:0002006 10.01 CYGB HIF1A IL1B NOS2 PLG PTGS2
18 reproductive system MP:0005389 9.93 ADAMTS1 ADM APOE BDNF CNTF CYGB
19 no phenotypic analysis MP:0003012 9.92 ADAMTS4 APOE AQP4 BDNF CNTF HYAL2
20 respiratory system MP:0005388 9.7 ADM APOE AQP4 BDNF EPHA3 HIF1A
21 vision/eye MP:0005391 9.32 APOE AQP4 BDNF HIF1A HYAL2 NOS2

Drugs & Therapeutics for Cerebral Artery Occlusion

Drugs for Cerebral Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nicardipine Approved, Investigational Phase 4 55985-32-5 4474
2
Labetalol Approved Phase 4 36894-69-6 3869
3 Mitogens Phase 4
4 Neurotransmitter Agents Phase 4
5 Adrenergic alpha-Antagonists Phase 4
6 Adrenergic beta-Antagonists Phase 4
7 Antihypertensive Agents Phase 4
8 Adrenergic Agents Phase 4
9 Hormones Phase 4
10 Adrenergic Antagonists Phase 4
11 Vasodilator Agents Phase 4
12 Sympathomimetics Phase 4
13 Adrenergic alpha-1 Receptor Antagonists Phase 4
14 Calcium, Dietary Phase 4
15 calcium channel blockers Phase 4
16
Calcium Nutraceutical Phase 4 7440-70-2 271
17
Clopidogrel Approved Phase 3 113665-84-2, 120202-66-6 60606
18
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
19 Fibrinolytic Agents Phase 3
20 Tissue Plasminogen Activator Phase 3
21 Analgesics, Non-Narcotic Phase 3
22 Purinergic P2Y Receptor Antagonists Phase 3
23 Cyclooxygenase Inhibitors Phase 3
24 Analgesics Phase 3
25 Platelet Aggregation Inhibitors Phase 3
26 Antipyretics Phase 3
27 Antirheumatic Agents Phase 3
28 Anti-Inflammatory Agents Phase 3
29 Anti-Inflammatory Agents, Non-Steroidal Phase 3
30
Deferoxamine Approved, Investigational Phase 2 70-51-9 2973
31
Iron Approved, Experimental Phase 2 15438-31-0, 7439-89-6 27284 23925
32
Fibrinolysin Investigational Phase 1, Phase 2 9004-09-5
33 Plasminogen Phase 2
34 Chelating Agents Phase 2
35 Iron Chelating Agents Phase 2
36 Anesthetics

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Effects of Intranasal Nerve Growth Factor for Acute Ischemic Stroke Recruiting NCT03686163 Phase 4 Nerve Growth Factors;normal saline
2 Outcome in Patients Treated With Intraarterial Thrombectomy - optiMAL Blood Pressure Control (OPTIMAL-BP) Not yet recruiting NCT04205305 Phase 4 conventional blood pressure control (labetalol, nicardipine);intensive blood pressure control (labetalol, nicardipine)
3 Transcranial Ultrasound Enhanced Thrombolysis (TRUST) Unknown status NCT00336596 Phase 3
4 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Active, not recruiting NCT01758614 Phase 3 Aspirin;Clopidogrel
5 A Phase 1/2a, Open Label, Dose Escalation, Safety Study of Intra-thrombus Plasmin (Human) Administration in Acute, Middle Cerebral Artery, Ischemic Stroke Completed NCT01014975 Phase 1, Phase 2
6 Double-blind, Randomized, Placebo Controlled, Dose-finding Phase 2 Clinical Trial of Intravenous Deferoxamine in Patients With Acute Ischemic Stroke Treated With Tissue Plasminogen Activator Completed NCT00777140 Phase 2 Deferoxamine
7 Randomized Therapeutic Study Assessing the Superiority of a Sequential Intravenous Thrombolysis Treatment (Rt-PA + Tenecteplase) in Comparison With Rt-PA Standard Treatment in Proximal Middle Cerebral Artery Occlusion (DIVA). Withdrawn NCT02338466 Phase 2 rt-PA;tenecteplase
8 Remote Ischaemic Conditioning in Endovascular Recanalization for Proximal Anterior Circulation Occlusion (RICE PAC) Study Unknown status NCT03152799 Phase 1
9 Incidence, Nature and Consequences of Cortical Depolarizations in Human Brain Injury From Trauma and Ischemia: The COSBID Study Unknown status NCT00258505
10 Transcranial Direct Current Stimulation (tDCS) in Acute Stroke Patients Unknown status NCT02806856
11 Evaluation of Clinical Results of Treatment of Cerebral Artery Occlusion by Mechanical Thrombectomy, in the Acute Phase of Stroke Completed NCT02880579
12 FRench Acute Cerebral Multimodal Imaging to Select Patient for MEchanical Thrombectomy Completed NCT03045146
13 Remote Ischemic Preconditioning for Carotid Endarterectomy Completed NCT02808754
14 Benefits of the Endovascular Treatment in the Early Management of Proximal Sylvian Artery Thrombosis in Patients Refractory or Ineligible to Intravenous Fibrinolysis : a Multicenter Controled Randomized Trial Terminated NCT02216565 Alteplase if patient is eligible

Search NIH Clinical Center for Cerebral Artery Occlusion

Genetic Tests for Cerebral Artery Occlusion

Anatomical Context for Cerebral Artery Occlusion

MalaCards organs/tissues related to Cerebral Artery Occlusion:

40
Brain, Bone, Endothelial, Bone Marrow, Cortex, Neutrophil, T Cells

Publications for Cerebral Artery Occlusion

Articles related to Cerebral Artery Occlusion:

(show top 50) (show all 10879)
# Title Authors PMID Year
1
RVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery. 61
32400219 2020
2
XingNaoJing injection ameliorates cerebral ischaemia/reperfusion injury via SIRT1-mediated inflammatory response inhibition. 61
31854225 2020
3
Paired associated magnetic stimulation promotes neural repair in the rat middle cerebral artery occlusion model of stroke. 61
32394960 2020
4
Demonstration of magnetization transfer and relaxation normalized pH-specific pulse-amide proton transfer imaging in an animal model of acute stroke. 61
32080897 2020
5
The Akt/glycogen synthase kinase-3β pathway participates in the neuroprotective effect of interleukin-4 against cerebral ischemia/reperfusion injury. 61
32209778 2020
6
An enriched environment increases the expression of fibronectin type III domain-containing protein 5 and brain-derived neurotrophic factor in the cerebral cortex of the ischemic mouse brain. 61
32209771 2020
7
Antioxidant nanomedicine with cytoplasmic distribution in neuronal cells shows superior neurovascular protection properties. 61
32504549 2020
8
An increase in AMPK/e-NOS signaling and attenuation of MMP-9 may contribute to remote ischemic perconditioning associated neuroprotection in rat model of focal ischemia. 61
32353433 2020
9
Delayed recanalization after MCAO ameliorates ischemic stroke by inhibiting apoptosis via HGF/c-Met/STAT3/Bcl-2 pathway in rats. 61
32428505 2020
10
Resveratrol reduces cerebral edema through inhibition of de novo SUR1 expression induced after focal ischemia. 61
32380020 2020
11
Moderate exercise has beneficial effects on mouse ischemic stroke by enhancing the functions of circulating endothelial progenitor cell-derived exosomes. 61
32325158 2020
12
Therapeutic treatment with vitamin C reduces focal cerebral ischemia-induced brain infarction in rats by attenuating disruptions of blood brain barrier and cerebral neuronal apoptosis. 61
32450129 2020
13
miR-18b attenuates cerebral ischemia/reperfusion injury through regulation of ANXA3 and PI3K/Akt signaling pathway. 61
32380186 2020
14
Triad3A displays a critical role in suppression of cerebral ischemic/reperfusion (I/R) injury by regulating necroptosis. 61
32460187 2020
15
miR-330 regulates Drp-1 mediated mitophagy by targeting PGAM5 in a rat model of permanent focal cerebral ischemia. 61
32360974 2020
16
HMGB1 promoted P-glycoprotein at the blood-brain barrier in MCAO rats via TLR4/NF-κB signaling pathway. 61
32417325 2020
17
Neuroprotective effect of low-intensity transcranial ultrasound stimulation in endothelin-1-induced middle cerebral artery occlusion in rats. 61
32439337 2020
18
Presynaptic Caytaxin prevents apoptosis via deactivating DAPK1 in the acute phase of cerebral ischemic stroke. 61
32277960 2020
19
rLj-RGD4, the shortened peptide of rLj-RGD3 from Lampetra japonica, protects against cerebral ischemia/reperfusion injury via the PI3K/Akt pathway. 61
32389578 2020
20
Environmental enrichment enhances post-ischemic cerebral blood flow and functional hyperemia in the ipsilesional somatosensory cortex. 61
32388014 2020
21
Pigment Epithelium-Derived Factor Improves Paracellular Blood-Brain Barrier Integrity in the Normal and Ischemic Mouse Brain. 61
31858356 2020
22
Human neural stem cells improve early stage stroke outcome in delayed tissue plasminogen activator-treated aged stroke brains. 61
32147438 2020
23
Adiponectin peptide alleviates oxidative stress and NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK/GSK-3β. 61
32275928 2020
24
AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice. 61
32201254 2020
25
Memantine ameliorates tau protein deposition and secondary damage in the ipsilateral thalamus and sensory decline following focal cortical infarction in rats. 61
32454152 2020
26
Contralesional Application of Transcranial Direct Current Stimulation on Functional Improvement in Ischemic Stroke Mice. 61
32521221 2020
27
Effect of hyperglycemia on stroke outcome is not homogeneous to all patients treated with mechanical thrombectomy. 61
32248045 2020
28
Neuroprotective Effects of Trilobatin, a Novel Naturally Occurring Sirt3 Agonist from Lithocarpus polystachyus Rehd., Mitigate Cerebral Ischemia/Reperfusion Injury: Involvement of TLR4/NF-κB and Nrf2/Keap-1 Signaling. 61
32212827 2020
29
Waggle needling wields preferable neuroprotective and anti-spastic effects on post-stroke spasticity rats by attenuating γ-aminobutyric acid transaminase and enhancing γ-aminobutyric acid. 61
32453018 2020
30
Antithrombin gamma attenuates macrophage/microglial activation and brain damage after transient focal cerebral ischemia in mice. 61
32305521 2020
31
Constraint-induced movement therapy improves functional recovery after ischemic stroke and its impacts on synaptic plasticity in sensorimotor cortex and hippocampus. 61
32298779 2020
32
miR-211-5p alleviates focal cerebral ischemia-reperfusion injury in rats by down-regulating the expression of COX2. 61
32311346 2020
33
Altered COVID-19 receptor ACE2 expression in a higher risk group for cerebrovascular disease and ischemic stroke. 61
32513532 2020
34
Impaired glymphatic system in secondary degeneration areas after ischemic stroke in rats. 61
32404284 2020
35
Neuroprotective and neuro-rehabilitative effects of acute purinergic receptor P2X4 (P2X4R) blockade after ischemic stroke. 61
32289314 2020
36
Shuxuening injection facilitates neurofunctional recovery via down-regulation of G-CSF-mediated granulocyte adhesion and diapedesis pathway in a subacute stroke mouse model. 61
32417690 2020
37
Sex differences in T cell immune responses, gut permeability and outcome after ischemic stroke in aged mice. 61
32058038 2020
38
Cepharanthine attenuates cerebral ischemia/reperfusion injury by reducing NLRP3 inflammasome-induced inflammation and oxidative stress via inhibiting 12/15-LOX signaling. 61
32559840 2020
39
Astilbin protects against cerebral ischaemia/reperfusion injury by inhibiting cellular apoptosis and ROS-NLRP3 inflammasome axis activation. 61
32413740 2020
40
let-7g counteracts endothelial dysfunction and ameliorating neurological functions in mouse ischemia/reperfusion stroke model. 61
32017988 2020
41
Primary endovascular treatment for acute ischemic stroke in teenage patients: a short case series. 61
32307558 2020
42
Up-regulation of sphingosine-1-phosphate receptors and sphingosine kinase 1 in the peri-ischemic area after transient middle cerebral artery occlusion in mice. 61
32278723 2020
43
Effect of fluoxetine on HIF-1α- Netrin/VEGF cascade, angiogenesis and neuroprotection in a rat model of transient middle cerebral artery occlusion. 61
32294470 2020
44
Baicalein attenuates caspase-independent cells death via inhibiting PARP-1 activation and AIF nuclear translocation in cerebral ischemia/reperfusion rats. 61
32338336 2020
45
Protective Effect of ApoA1 (Apolipoprotein A1)-Milano in a Rat Model of Large Vessel Occlusion Stroke. 61
32404037 2020
46
Roles of GluN2C in cerebral ischemia: GluN2C expressed in different cell types plays different role in ischemic damage. 61
31820502 2020
47
Design and development of novel thiazolidin-4-one-1,3,5-triazine derivatives as neuro-protective agent against cerebral ischemia reperfusion injury in mice via attenuation of NF-ĸB. 61
32543026 2020
48
tDCS Accelerates the Rehabilitation of MCAO-Induced Motor Function Deficits via Neurogenesis Modulated by the Notch1 Signaling Pathway. 61
32543269 2020
49
Prothymosin alpha and its mimetic hexapeptide improve delayed tissue plasminogen activator-induced brain damage following cerebral ischemia. 61
31454420 2020
50
Functional connectivity of the retrosplenial cortex in rats with ischemic stroke is improved by electroacupuncture. 61
32529883 2020

Variations for Cerebral Artery Occlusion

Expression for Cerebral Artery Occlusion

Search GEO for disease gene expression data for Cerebral Artery Occlusion.

Pathways for Cerebral Artery Occlusion

Pathways related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.55 TNF PTGS2 NOS3 NOS2 IL1B GDNF
2
Show member pathways
13.25 TNF PTGS2 NOS2 IL1B HIF1A GDNF
3
Show member pathways
13.07 TNF PTGS2 NOS2 IL1B BDNF APOE
4
Show member pathways
12.39 TNF PLG NOS3 NOS2 IL1B
5
Show member pathways
12.21 TNF PTGS2 NOS2 IL1B
6
Show member pathways
12.13 TNF PTGS2 NOS2 IL1B
7
Show member pathways
12.05 TNF PTGS2 PLG IL1B APOE
8 11.76 TNF IL1B HIF1A BDNF AQP4
9 11.68 GDNF CNTF BDNF
10 11.65 TNF NOS2 IL1B
11 11.62 PTGS2 NOS3 HIF1A ADAMTS1
12 11.57 NOS3 NOS2 HIF1A
13 11.56 NOS2 HIF1A ADM
14
Show member pathways
11.47 ODC1 NOS3 NOS2
15 11.41 PTGS2 NOS2 HIF1A
16 11.41 TNF PTGS2 NOS2 IL1B HIF1A
17 11.38 TNF PTGS2 IL1B
18
Show member pathways
11.36 TNF PTGS2 NOS2 IL1B
19 11.35 TNF NOS2 IL1B
20 11.31 TNF IL1B APOE
21 11.25 TNF PTGS2 NOS2 IL1B GDNF BDNF
22 11.18 PTGS2 NOS2 HIF1A
23 11.03 PTGS2 NOS3 NOS2
24 10.73 NOS3 NOS2
25 10.49 NOS3 NOS2

GO Terms for Cerebral Artery Occlusion

Cellular components related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.7 PLG NOS3 NOS2 HIF1A AQP4 APOE
2 extracellular space GO:0005615 9.61 TNF PLG IL1B GDNF CNTF BDNF
3 extracellular region GO:0005576 9.4 TNF PLG IL1B GDNF EPHA3 CNTF

Biological processes related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.05 TNF NOS3 IL1B HIF1A CNTF
2 inflammatory response GO:0006954 10.02 TNF PTGS2 NOS2 IL1B ADM
3 positive regulation of cell proliferation GO:0008284 10.02 PTGS2 ODC1 IL1B GDNF CNTF ADM
4 negative regulation of cell proliferation GO:0008285 9.95 PTGS2 PLG NOS3 IL1B ADM ADAMTS1
5 regulation of cell proliferation GO:0042127 9.94 TNF PTGS2 NOS2 HIF1A
6 response to hypoxia GO:0001666 9.91 NOS2 HIF1A CYGB ADM
7 positive regulation of angiogenesis GO:0045766 9.9 NOS3 IL1B HIF1A ADM
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.85 TNF PTGS2 BDNF
9 cellular oxidant detoxification GO:0098869 9.83 PTGS2 CYGB APOE
10 regulation of insulin secretion GO:0050796 9.83 TNF NOS2 IL1B
11 response to glucocorticoid GO:0051384 9.81 TNF PTGS2 ADM
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 TNF PTGS2 IL1B
13 positive regulation of interleukin-6 secretion GO:2000778 9.76 TNF IL1B HYAL2
14 negative regulation of MAP kinase activity GO:0043407 9.75 IL1B HYAL2 APOE
15 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.73 TNF IL1B GDNF
16 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 TNF NOS3 IL1B
17 positive regulation of vascular endothelial growth factor production GO:0010575 9.69 PTGS2 IL1B HIF1A
18 positive regulation of chemokine biosynthetic process GO:0045080 9.68 TNF IL1B
19 nitric oxide biosynthetic process GO:0006809 9.68 NOS3 NOS2
20 positive regulation of neuroinflammatory response GO:0150078 9.67 TNF IL1B
21 negative regulation of fibroblast migration GO:0010764 9.67 HYAL2 CYGB
22 positive regulation of guanylate cyclase activity GO:0031284 9.66 NOS3 NOS2
23 negative regulation of platelet activation GO:0010544 9.65 NOS3 APOE
24 response to lipopolysaccharide GO:0032496 9.65 PTGS2 NOS3 NOS2 IL1B ADM
25 regulation of establishment of endothelial barrier GO:1903140 9.63 TNF IL1B
26 ovulation from ovarian follicle GO:0001542 9.63 NOS3 ADAMTS1
27 positive regulation of nitric-oxide synthase activity GO:0051000 9.63 TNF HIF1A APOE
28 arginine catabolic process GO:0006527 9.62 NOS3 NOS2
29 positive regulation of prostaglandin biosynthetic process GO:0031394 9.61 PTGS2 IL1B
30 regulation of nitric-oxide synthase activity GO:0050999 9.61 NOS3 IL1B CYGB
31 nitric oxide mediated signal transduction GO:0007263 9.58 NOS3 NOS2 APOE
32 sequestering of triglyceride GO:0030730 9.57 TNF IL1B
33 negative regulation of neuron apoptotic process GO:0043524 9.55 HIF1A GDNF CNTF BDNF APOE
34 astrocyte activation GO:0048143 9.54 TNF IL1B CNTF
35 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.52 TNF IL1B
36 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.5 TNF IL1B APOE
37 regulation of retinal cell programmed cell death GO:0046668 9.49 CNTF BDNF
38 cytokine-mediated signaling pathway GO:0019221 9.43 TNF PTGS2 NOS2 IL1B HIF1A CNTF
39 positive regulation of fever generation GO:0031622 8.8 TNF PTGS2 IL1B

Molecular functions related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.36 TSPAN33 TNF PTGS2 PLG ODC1 NOS3
2 signaling receptor binding GO:0005102 9.77 PLG GDNF BDNF APOE ADM
3 enzyme binding GO:0019899 9.65 TSPAN33 PTGS2 PLG HYAL2 HIF1A
4 arginine binding GO:0034618 9.43 NOS3 NOS2
5 NADPH-hemoprotein reductase activity GO:0003958 9.32 NOS3 NOS2
6 heme binding GO:0020037 9.26 PTGS2 NOS3 NOS2 CYGB
7 tetrahydrobiopterin binding GO:0034617 9.16 NOS3 NOS2
8 nitric-oxide synthase activity GO:0004517 8.62 NOS3 NOS2

Sources for Cerebral Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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