MCID: CRB004
MIFTS: 45

Cerebral Artery Occlusion

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Cerebral Artery Occlusion

MalaCards integrated aliases for Cerebral Artery Occlusion:

Name: Cerebral Artery Occlusion 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:10127
ICD9CM 34 434
SNOMED-CT 67 20059004
UMLS 71 C0028790

Summaries for Cerebral Artery Occlusion

MalaCards based summary : Cerebral Artery Occlusion is related to brain edema and brain injury. An important gene associated with Cerebral Artery Occlusion is BDNF (Brain Derived Neurotrophic Factor), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. The drugs Aspirin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and bone marrow, and related phenotypes are behavior/neurological and cardiovascular system

Related Diseases for Cerebral Artery Occlusion

Diseases related to Cerebral Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 283)
# Related Disease Score Top Affiliating Genes
1 brain edema 31.5 NOS2 IL1B AQP4
2 brain injury 31.2 IL1B BDNF AQP4 APOE
3 carotid artery occlusion 31.2 NOS3 IL1B BDNF
4 ischemia 30.8 NOS3 NOS2 NOS1 HIF1A BDNF ADM
5 carotid stenosis 30.8 TNF NOS3 APOE
6 encephalomalacia 30.5 TNF IL1B BDNF
7 retinal ischemia 30.5 TNF HIF1A CNTF BDNF
8 stroke, ischemic 30.4 TNF NOS3 IL1B GDNF BDNF AQP4
9 traumatic brain injury 30.4 IL1B BDNF AQP4 APOE
10 meningitis 30.1 TNF IL1B GDNF AQP4
11 congestive heart failure 30.1 TNF NOS3 IL1B ADM
12 vascular dementia 30.1 TNF IL1B APOE
13 pain agnosia 30.1 TNF PTGS2 IL1B BDNF
14 renovascular hypertension 30.1 NOS3 NOS1 ADM
15 vascular disease 30.0 TNF PTGS2 NOS3 NOS2 NOS1 APOE
16 arteries, anomalies of 30.0 TNF NOS3 IL1B APOE
17 intracranial aneurysm 30.0 TNF NOS3 APOE
18 hydrocephalus 29.9 TNF GDNF BDNF AQP4 APOE
19 sleep disorder 29.9 TNF IL1B HIF1A BDNF APOE
20 narcolepsy 29.8 TNF IL1B GDNF BDNF AQP4 APOE
21 sleep apnea 29.7 TNF NOS3 IL1B HIF1A BDNF APOE
22 migraine with or without aura 1 29.3 TNF PTGS2 NOS3 NOS1 IL1B BDNF
23 parkinson disease, late-onset 28.9 NOS1 GDNF EPHA3 CNTF BDNF APOE
24 lipoprotein quantitative trait locus 28.9 TNF NOS3 NOS2 IL1B HIF1A CYGB
25 heart disease 28.8 TNF PTGS2 NOS3 NOS2 IL1B HIF1A
26 diabetes mellitus 28.8 TNF PTGS2 NOS3 NOS2 NOS1 IL1B
27 alzheimer disease 28.8 TNF PTGS2 NOS3 NOS1 IL1B GDNF
28 transient cerebral ischemia 10.6
29 hemiplegia 10.5
30 48,xyyy 10.5
31 aphasia 10.5
32 moyamoya disease 1 10.5
33 hyperglycemia 10.5
34 cerebrovascular disease 10.4
35 aneurysm 10.4
36 physiological polycythemia 10.4 TNF IL1B
37 hypoxia 10.4
38 staphylococcal toxic shock syndrome 10.4 TNF IL1B
39 subjective cognitive decline 10.4 BDNF APOE
40 mesial temporal lobe epilepsy with hippocampal sclerosis 10.4 IL1B APOE
41 vulvar vestibulitis syndrome 10.3 TNF IL1B
42 palladium allergic contact dermatitis 10.3 TNF IL1B
43 kashin-beck disease 10.3 TNF IL1B
44 cerebral aneurysms 10.3
45 cerebral hypoxia 10.3
46 inflammatory bowel disease 25 10.3 TNF PTGS2
47 lumbosacral lipoma 10.3 IL1B HIF1A
48 platelet membrane fluidity 10.3 NOS3 NOS2
49 arachnoiditis 10.3 TNF IL1B AQP4
50 cerebritis 10.3 TNF IL1B AQP4

Graphical network of the top 20 diseases related to Cerebral Artery Occlusion:



Diseases related to Cerebral Artery Occlusion

Symptoms & Phenotypes for Cerebral Artery Occlusion

MGI Mouse Phenotypes related to Cerebral Artery Occlusion:

46 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.46 ADAMTS4 ADM APOE AQP4 BDNF CNTF
2 cardiovascular system MP:0005385 10.42 ADAMTS1 ADM APOE AQP4 CYGB EPHA3
3 growth/size/body region MP:0005378 10.41 ADAMTS1 APOE AQP4 BDNF CYGB GDNF
4 homeostasis/metabolism MP:0005376 10.41 ADAMTS1 ADM APOE AQP4 BDNF CNTF
5 hematopoietic system MP:0005397 10.4 ADAMTS1 ADM APOE AQP4 CNTF GDNF
6 endocrine/exocrine gland MP:0005379 10.39 ADAMTS1 ADM APOE AQP4 BDNF CNTF
7 mortality/aging MP:0010768 10.39 ADAMTS1 ADAMTS4 ADM APOE AQP4 BDNF
8 cellular MP:0005384 10.38 ADM APOE BDNF CNTF CYGB GDNF
9 immune system MP:0005387 10.37 ADAMTS1 ADM APOE AQP4 CNTF GDNF
10 digestive/alimentary MP:0005381 10.26 APOE AQP4 BDNF GDNF HIF1A NOS1
11 liver/biliary system MP:0005370 10.22 ADM APOE CYGB EPHA3 HIF1A HYAL2
12 nervous system MP:0003631 10.22 ADAMTS4 APOE AQP4 BDNF CNTF GDNF
13 muscle MP:0005369 10.17 ADM APOE CNTF CYGB GDNF HIF1A
14 renal/urinary system MP:0005367 10.13 ADAMTS1 ADAMTS4 ADM APOE AQP4 CYGB
15 reproductive system MP:0005389 10.03 ADAMTS1 ADM APOE BDNF CNTF CYGB
16 no phenotypic analysis MP:0003012 10.02 ADAMTS4 APOE AQP4 BDNF CNTF HYAL2
17 respiratory system MP:0005388 9.93 ADM APOE AQP4 BDNF CYGB EPHA3
18 skeleton MP:0005390 9.65 ADAMTS4 APOE HIF1A HYAL2 IL1B NOS1
19 vision/eye MP:0005391 9.36 ADAMTS1 APOE AQP4 BDNF HIF1A HYAL2

Drugs & Therapeutics for Cerebral Artery Occlusion

Drugs for Cerebral Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
2
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
3 Anti-Inflammatory Agents Phase 3
4 Neurotransmitter Agents Phase 3
5 Analgesics, Non-Narcotic Phase 3
6 Anti-Inflammatory Agents, Non-Steroidal Phase 3
7 Platelet Aggregation Inhibitors Phase 3
8 Analgesics Phase 3
9 Antirheumatic Agents Phase 3
10 Cyclooxygenase Inhibitors Phase 3
11 Purinergic P2Y Receptor Antagonists Phase 3
12 Antipyretics Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Active, not recruiting NCT01758614 Phase 3 Aspirin;Clopidogrel
2 Randomized Therapeutic Study Assessing the Superiority of a Sequential Intravenous Thrombolysis Treatment (Rt-PA + Tenecteplase) in Comparison With Rt-PA Standard Treatment in Proximal Middle Cerebral Artery Occlusion (DIVA). Withdrawn NCT02338466 Phase 2 rt-PA;tenecteplase
3 Evaluation of Clinical Results of Treatment of Cerebral Artery Occlusion by Mechanical Thrombectomy, in the Acute Phase of Stroke Completed NCT02880579
4 Predicting Value of DWI Total Posterior-circulation Infarct Volume for Endovascular Treatment Outcomes of Acute Basilar Artery Occlusion Completed NCT04650022
5 DWI Cerebellar Infarct Volume as Predictor of Outcomes After Endovascular Treatment of Acute Basilar Artery Occlusion Completed NCT04611178
6 Endovascular Thrombectomy in COVID-19 Infected Patients: Intrahospital and Peri-operative Outcomes Completed NCT04406090
7 Systemic Inflammation During Recanalization of Cerebral Arterial Occlusion Not yet recruiting NCT04731584

Search NIH Clinical Center for Cerebral Artery Occlusion

Genetic Tests for Cerebral Artery Occlusion

Anatomical Context for Cerebral Artery Occlusion

MalaCards organs/tissues related to Cerebral Artery Occlusion:

40
Brain, Endothelial, Bone Marrow, Cortex, Thalamus, Neutrophil, T Cells

Publications for Cerebral Artery Occlusion

Articles related to Cerebral Artery Occlusion:

(show top 50) (show all 11453)
# Title Authors PMID Year
1
Extremely low frequency electromagnetic fields promote cognitive function and hippocampal neurogenesis of rats with cerebral ischemia. 61
33318402 2021
2
Apelin-13 inhibits apoptosis and excessive autophagy in cerebral ischemia/reperfusion injury. 61
33269749 2021
3
Normobaric oxygen therapy attenuates hyperglycolysis in ischemic stroke. 61
33269745 2021
4
An integrative multivariate approach for predicting functional recovery using magnetic resonance imaging parameters in a translational pig ischemic stroke model. 61
33229718 2021
5
Enriched environment boosts the post-stroke recovery of neurological function by promoting autophagy. 61
33229714 2021
6
Kellerin from Ferula sinkiangensis exerts neuroprotective effects after focal cerebral ischemia in rats by inhibiting microglia-mediated inflammatory responses. 61
33352239 2021
7
Treadmill exercise enhances synaptic plasticity in the ischemic penumbra of MCAO mice by inducing the expression of Camk2a via CYFIP1 upregulation. 61
33497737 2021
8
Selective-cerebral-hypothermia-induced neuroprotection against-focal cerebral ischemia/reperfusion injury is associated with an increase in SUMO2/3 conjugation. 61
33539797 2021
9
MicroRNA-376b-5p targets SOX7 to alleviate ischemic brain injury in a mouse model through activating Wnt/β-catenin signaling pathway. 61
33482187 2021
10
Dynamic changes of inflammation and apoptosis in cerebral ischemia‑reperfusion injury in mice investigated by ferumoxytol‑enhanced magnetic resonance imaging. 61
33604682 2021
11
Carthamin yellow improves cerebral ischemia‑reperfusion injury by attenuating inflammation and ferroptosis in rats. 61
33576458 2021
12
Orexin-A alleviates cerebral ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress-mediated apoptosis. 61
33576468 2021
13
Study of common quantification methods of amide proton transfer magnetic resonance imaging for ischemic stroke detection. 61
33107119 2021
14
Salvianolic Acids for Injection alleviates cerebral ischemia/reperfusion injury by switching M1/M2 phenotypes and inhibiting NLRP3 inflammasome/pyroptosis axis in microglia in vivo and in vitro. 61
33421597 2021
15
Expression of fibroblast growth factor 9 and its receptors in the dentate gyrus of hippocampus in poststroke depression rats. 61
33470768 2021
16
Up-regulating lncRNA OIP5-AS1 protects neuron injury against cerebral hypoxia-ischemia induced inflammation and oxidative stress in microglia/macrophage through activating CTRP3 via sponging miR-186-5p. 61
33516048 2021
17
Mutant erythropoietin enhances white matter repair via the JAK2/STAT3 and C/EBPβ pathway in middle-aged mice following cerebral ischemia and reperfusion. 61
33309747 2021
18
GJ-4 ameliorates memory impairment in focal cerebral ischemia/reperfusion of rats via inhibiting JAK2/STAT1-mediated neuroinflammation. 61
33091490 2021
19
Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR pathway. 61
33212156 2021
20
Down-Regulation of miR-181a-5p Prevents Cerebral Ischemic Injury by Upregulating En2 and Activating Wnt/β-catenin Pathway. 61
33360253 2021
21
Continuous Glibenclamide Prevents Hemorrhagic Transformation in a Rodent Model of Severe Ischemia-Reperfusion. 61
33450605 2021
22
Astragaloside IV promotes microglia/macrophages M2 polarization and enhances neurogenesis and angiogenesis through PPARγ pathway after cerebral ischemia/reperfusion injury in rats. 61
33429332 2021
23
Comparison Between Three Commonly Used Large-Bore Aspiration Catheters in Terms of Successful Recanalization and First-Passage Effect. 61
33360517 2021
24
Xanthoangelol alleviates cerebral ischemia reperfusion injury in rats. 61
32589370 2021
25
Knockdown of TRIM22 Relieves Oxygen-Glucose Deprivation/Reoxygenation-Induced Apoptosis and Inflammation Through Inhibition of NF-κB/NLRP3 Axis. 61
32335773 2021
26
Evans Blue Might Produce Pathologically Activated Neuroprotective Effects via the Inhibition of the P2X4R/p38 Signaling Pathway. 61
32382851 2021
27
Development of fast multi-slice apparent T1 mapping for improved arterial spin labeling MRI measurement of cerebral blood flow. 61
32970848 2021
28
Neuroprotective effects of troxerutin and cerebroprotein hydrolysate injection on the neurovascular unit in a rat model of Middle cerebral artery occlusion. 61
32125198 2021
29
Electric Acupuncture Treatment Promotes Angiogenesis in Rats with Middle Cerebral Artery Occlusion Through EphB4/EphrinB2 Mediated Src/PI3K Signal Pathway. 61
33360522 2021
30
The effects of hyperbaric oxygen therapy on the brain with middle cerebral artery occlusion. 61
32692455 2021
31
Feasibility and safety of thrombectomy for isolated occlusions of the posterior cerebral artery: a multicenter experience and systematic literature review. 61
32527938 2021
32
Intensive treadmill training promotes cognitive recovery after cerebral ischemia-reperfusion in juvenile rats. 61
33358915 2021
33
The conditioned medium of human embryonic stem cell-derived mesenchymal stem cells alleviates neurological deficits and improves synaptic recovery in experimental stroke. 61
32730642 2021
34
ECM hydrogel improves the delivery of PEG microsphere-encapsulated neural stem cells and endothelial cells into tissue cavities caused by stroke. 61
33373665 2021
35
The pathophysiological mechanism of ischemic stroke after hypobaric hypoxia simulation at high altitude. 61
33411214 2021
36
Activin A improves the neurological outcome after ischemic stroke in mice by promoting oligodendroglial ACVR1B-mediated white matter remyelination. 61
33345977 2021
37
Neuroprotective effects of microRNA-140-5p on ischemic stroke in mice via regulation of the TLR4/NF-κB axis. 61
33246036 2021
38
QSM in canine model of acute cerebral ischemia: A pilot study. 61
33034078 2021
39
Electroacupuncture alleviates ischaemic brain injury by regulating the miRNA-34/Wnt/autophagy axis. 61
33556563 2021
40
Exosomal microRNA-22-3p alleviates cerebral ischemic injury by modulating KDM6B/BMP2/BMF axis. 61
33546766 2021
41
Phosphorylation at S548 as a Functional Switch of Sterile Alpha and TIR Motif-Containing 1 in Cerebral Ischemia/Reperfusion Injury in Rats. 61
32968873 2021
42
Long non‑coding RNA H19 inhibition ameliorates oxygen‑glucose deprivation‑induced cell apoptosis and inflammatory cytokine expression by regulating the microRNA‑29b/SIRT1/PGC‑1α axis. 61
33313940 2021
43
Progranulin promotes functional recovery and neurogenesis in the subventricular zone of adult mice after cerebral ischemia. 61
33539798 2021
44
CQMUH-011 Inhibits LPS-Induced Microglia Activation and Ameliorates Brain Ischemic Injury in Mice. 61
33528726 2021
45
Lipoxin A4 regulates microglial M1/M2 polarization after cerebral ischemia-reperfusion injury via the Notch signaling pathway. 61
33600815 2021
46
DDAH-1, via regulation of ADMA levels, protects against ischemia-induced blood-brain barrier leakage. 61
33574439 2021
47
The neuroprotective role of SIRT1/PGC-1α signaling in limb postconditioning in cerebral ischemia/reperfusion injury. 61
33600904 2021
48
miR-374 improves cerebral ischemia reperfusion injury by targeting Wnt5a. 61
33116025 2021
49
Circular RNA TTC3 regulates cerebral ischemia-reperfusion injury and neural stem cells by miR-372-3p/TLR4 axis in cerebral infarction. 61
33579365 2021
50
MicroRNA-26b-5p alleviates cerebral ischemia-reperfusion injury in rats via inhibiting the N-myc/PTEN axis by downregulating KLF10 expression. 61
33559506 2021

Variations for Cerebral Artery Occlusion

Expression for Cerebral Artery Occlusion

Search GEO for disease gene expression data for Cerebral Artery Occlusion.

Pathways for Cerebral Artery Occlusion

Pathways related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 TNF PTGS2 NOS3 NOS2 NOS1 IL1B
2
Show member pathways
13.24 TNF PTGS2 NOS2 IL1B IL16 HIF1A
3
Show member pathways
12.51 TNF NOS3 NOS2 NOS1 IL1B
4 12.33 NOS3 NOS2 NOS1 GDNF
5
Show member pathways
12.27 TNF PTGS2 IL1B APOE
6
Show member pathways
12.25 TNF PTGS2 NOS2 IL1B
7
Show member pathways
12.19 TNF PTGS2 NOS2 IL1B
8 12.04 TNF NOS1 IL1B APOE
9 12.01 TNF IL1B HIF1A BDNF AQP4
10 11.73 PTGS2 NOS3 HIF1A ADAMTS1
11 11.72 GDNF CNTF BDNF
12 11.7 TNF NOS2 IL1B
13 11.63 NOS3 NOS2 HIF1A
14 11.62 NOS2 HIF1A ADM
15 11.61 TNF PTGS2 NOS2 IL1B HIF1A
16
Show member pathways
11.57 NOS3 NOS2 NOS1
17
Show member pathways
11.56 TNF PTGS2 NOS2 IL1B
18 11.49 PTGS2 NOS2 HIF1A
19 11.47 TNF PTGS2 IL1B
20 11.46 TNF NOS2 IL1B
21 11.42 TNF IL1B APOE
22
Show member pathways
11.39 TNF NOS1 IL1B
23
Show member pathways
11.39 ODC1 NOS3 NOS2 NOS1
24
Show member pathways
11.36 NOS3 NOS2 NOS1
25
Show member pathways
11.33 NOS3 NOS2 NOS1
26 11.3 TNF PTGS2 NOS2 NOS1 IL1B GDNF
27 11.28 PTGS2 NOS2 HIF1A
28
Show member pathways
11.12 NOS3 NOS2 NOS1
29 11.05 NOS3 NOS2 NOS1
30 10.72 NOS3 NOS2 NOS1
31 10.7 PTGS2 NOS3 NOS2 NOS1
32 10.34 NOS3 NOS2 NOS1

GO Terms for Cerebral Artery Occlusion

Cellular components related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.13 PTGS2 ODC1 NOS3 NOS2 NOS1 IL1B
2 extracellular space GO:0005615 9.81 TNF IL1B IL16 GDNF CNTF BDNF
3 extracellular region GO:0005576 9.4 TNF IL1B IL16 GDNF EPHA3 CNTF
4 vesicle membrane GO:0012506 9.13 NOS3 NOS2 NOS1

Biological processes related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.08 TNF NOS3 IL1B HIF1A CNTF
2 negative regulation of cell proliferation GO:0008285 10.06 PTGS2 NOS3 IL1B ADM ADAMTS1
3 inflammatory response GO:0006954 10.04 TNF PTGS2 NOS2 IL1B ADM
4 regulation of cell proliferation GO:0042127 9.96 TNF PTGS2 NOS2 HIF1A
5 positive regulation of angiogenesis GO:0045766 9.92 NOS3 IL1B HIF1A ADM
6 response to organic substance GO:0010033 9.86 TNF PTGS2 ADM
7 cellular oxidant detoxification GO:0098869 9.86 PTGS2 CYGB APOE
8 positive regulation of inflammatory response GO:0050729 9.86 TNF IL1B IL16 HYAL2
9 regulation of insulin secretion GO:0050796 9.85 TNF NOS2 IL1B
10 positive regulation of interleukin-6 production GO:0032755 9.85 TNF IL1B IL16 HYAL2
11 response to hypoxia GO:0001666 9.85 NOS2 NOS1 HIF1A CYGB ADM
12 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.84 TNF PTGS2 NOS1 BDNF
13 response to glucocorticoid GO:0051384 9.83 TNF PTGS2 ADM
14 cell redox homeostasis GO:0045454 9.83 NOS3 NOS2 NOS1
15 negative regulation of neuron apoptotic process GO:0043524 9.83 HIF1A GDNF CNTF BDNF APOE
16 response to hormone GO:0009725 9.82 NOS3 NOS2 NOS1
17 positive regulation of interleukin-8 production GO:0032757 9.82 TNF IL1B HYAL2
18 positive regulation of nitric oxide biosynthetic process GO:0045429 9.8 TNF PTGS2 IL1B
19 negative regulation of MAP kinase activity GO:0043407 9.79 IL1B HYAL2 APOE
20 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.78 TNF IL1B GDNF
21 positive regulation of vascular endothelial growth factor production GO:0010575 9.77 PTGS2 IL1B HIF1A
22 negative regulation of blood pressure GO:0045776 9.76 NOS3 NOS2 NOS1
23 vasodilation GO:0042311 9.75 NOS3 NOS1 APOE
24 positive regulation of nitric-oxide synthase activity GO:0051000 9.74 TNF HIF1A APOE
25 regulation of nitric-oxide synthase activity GO:0050999 9.7 NOS3 IL1B CYGB
26 negative regulation of fibroblast migration GO:0010764 9.69 HYAL2 CYGB
27 response to reactive oxygen species GO:0000302 9.69 HYAL2 HIF1A APOE
28 positive regulation of neuroinflammatory response GO:0150078 9.68 TNF IL1B
29 regulation of establishment of endothelial barrier GO:1903140 9.68 TNF IL1B
30 negative regulation of platelet activation GO:0010544 9.67 NOS3 APOE
31 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.67 TNF IL1B APOE
32 positive regulation of prostaglandin biosynthetic process GO:0031394 9.65 PTGS2 IL1B
33 nitric oxide biosynthetic process GO:0006809 9.65 NOS3 NOS2 NOS1
34 peptidyl-cysteine S-nitrosylation GO:0018119 9.63 NOS2 NOS1
35 response to lipopolysaccharide GO:0032496 9.63 PTGS2 NOS3 NOS2 NOS1 IL1B ADM
36 sequestering of triglyceride GO:0030730 9.61 TNF IL1B
37 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.6 TNF IL1B
38 positive regulation of guanylate cyclase activity GO:0031284 9.58 NOS3 NOS2 NOS1
39 vascular endothelial growth factor production GO:0010573 9.54 TNF IL1B HIF1A
40 arginine catabolic process GO:0006527 9.5 NOS3 NOS2 NOS1
41 cytokine-mediated signaling pathway GO:0019221 9.5 TNF PTGS2 NOS2 IL1B IL16 HIF1A
42 positive regulation of fever generation GO:0031622 9.43 TNF PTGS2 IL1B
43 nitric oxide mediated signal transduction GO:0007263 8.92 NOS3 NOS2 NOS1 APOE

Molecular functions related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.49 TNF PTGS2 ODC1 NOS3 NOS2 NOS1
2 cytokine activity GO:0005125 9.8 TNF IL1B IL16 CNTF
3 heme binding GO:0020037 9.72 PTGS2 NOS3 NOS2 NOS1 CYGB
4 flavin adenine dinucleotide binding GO:0050660 9.65 NOS3 NOS2 NOS1
5 NADP binding GO:0050661 9.61 NOS3 NOS2 NOS1
6 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 9.58 NOS3 NOS2 NOS1
7 FMN binding GO:0010181 9.54 NOS3 NOS2 NOS1
8 cadmium ion binding GO:0046870 9.46 NOS3 NOS1
9 arginine binding GO:0034618 9.43 NOS3 NOS2 NOS1
10 NADPH-hemoprotein reductase activity GO:0003958 9.33 NOS3 NOS2 NOS1
11 tetrahydrobiopterin binding GO:0034617 9.13 NOS3 NOS2 NOS1
12 nitric-oxide synthase activity GO:0004517 8.8 NOS3 NOS2 NOS1

Sources for Cerebral Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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