MCID: CRB004
MIFTS: 46

Cerebral Artery Occlusion

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Cerebral Artery Occlusion

MalaCards integrated aliases for Cerebral Artery Occlusion:

Name: Cerebral Artery Occlusion 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:10127
ICD9CM 35 434 434.9
UMLS 73 C0028790

Summaries for Cerebral Artery Occlusion

MalaCards based summary : Cerebral Artery Occlusion is related to arteries, anomalies of and myocardial infarction. An important gene associated with Cerebral Artery Occlusion is BDNF (Brain Derived Neurotrophic Factor), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Abciximab and Fibrinolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and cortex, and related phenotypes are cardiovascular system and cellular

Related Diseases for Cerebral Artery Occlusion

Diseases related to Cerebral Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 155)
# Related Disease Score Top Affiliating Genes
1 arteries, anomalies of 29.1 IL1B NOS3 TNF
2 myocardial infarction 28.2 HIF1A IL1B NOS3 TNF
3 cerebritis 11.1
4 brachial plexus lesion 10.6 BDNF GDNF
5 ischemia 10.5
6 systemic onset juvenile idiopathic arthritis 10.5 IL1B TNF
7 staphylococcal toxic shock syndrome 10.5 IL1B TNF
8 autoimmune myocarditis 10.5 IL1B TNF
9 kashin-beck disease 10.5 IL1B TNF
10 burns 10.5 IL1B TNF
11 laryngitis 10.5 IL1B TNF
12 haemophilus influenzae 10.5 IL1B TNF
13 retinitis pigmentosa 60 10.5 IL1B TNF
14 early-onset schizophrenia 10.5 BDNF TNF
15 irritant dermatitis 10.5 IL1B TNF
16 actinic prurigo 10.5 IL1B TNF
17 poems syndrome 10.5 IL1B TNF
18 crohn's colitis 10.5 IL1B TNF
19 meningoencephalitis 10.5 BDNF GDNF
20 central nervous system vasculitis 10.5 IL1B TNF
21 stachybotrys chartarum 10.5 IL1B TNF
22 dental pulp disease 10.4 IL1B TNF
23 eales disease 10.4 IL1B TNF
24 blau syndrome 10.4 IL1B TNF
25 endometritis 10.4 IL1B TNF
26 scrub typhus 10.4 IL1B TNF
27 pulpitis 10.4 IL1B TNF
28 middle ear disease 10.4 IL1B TNF
29 critical limb ischemia 10.4 HIF1A TNF
30 pleural disease 10.4 IL1B TNF
31 neuronitis 10.4
32 commensal bacterial infectious disease 10.4 IL1B TNF
33 q fever 10.4 IL1B TNF
34 lacrimal apparatus disease 10.4 IL1B TNF
35 perinatal necrotizing enterocolitis 10.4 IL1B TNF
36 palindromic rheumatism 10.4 IL1B TNF
37 progressive multifocal leukoencephalopathy 10.3 HIF1A TNF
38 extrinsic cardiomyopathy 10.3 IL1B TNF
39 viral encephalitis 10.3 IL1B TNF
40 endogenous depression 10.3 BDNF IL1B
41 complex regional pain syndrome 10.3 IL1B TNF
42 uterine anomalies 10.3 IL1B TNF
43 retinal ischemia 10.2 HIF1A TNF
44 chikungunya 10.2 IL1B TNF
45 purulent labyrinthitis 10.2 IL1B NOS3
46 ischemic heart disease 10.2 NOS3 TNF
47 keratoconjunctivitis sicca 10.2 IL1B TNF
48 prostatitis 10.2 IL1B TNF
49 spinal cord injury 10.2 BDNF GDNF TNF
50 brain injury 10.2

Graphical network of the top 20 diseases related to Cerebral Artery Occlusion:



Diseases related to Cerebral Artery Occlusion

Symptoms & Phenotypes for Cerebral Artery Occlusion

MGI Mouse Phenotypes related to Cerebral Artery Occlusion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 IL1RN NOS3 EPHA3 TNF GDNF HIF1A
2 cellular MP:0005384 9.87 IL1RN NOS3 BDNF ODC1 TNF GDNF
3 growth/size/body region MP:0005378 9.76 IL1RN NOS3 BDNF ODC1 TNF GDNF
4 digestive/alimentary MP:0005381 9.65 NOS3 BDNF TNF GDNF HIF1A
5 mortality/aging MP:0010768 9.61 NOS3 BDNF ODC1 EPHA3 TNF GDNF
6 respiratory system MP:0005388 9.02 NOS3 BDNF EPHA3 TNF HIF1A

Drugs & Therapeutics for Cerebral Artery Occlusion

Drugs for Cerebral Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abciximab Approved Phase 4 143653-53-6
2 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Not Applicable
3 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2
4 Tissue Plasminogen Activator Phase 4,Phase 3,Phase 2,Not Applicable
5 Anticoagulants Phase 4,Phase 2
6 Plasminogen Phase 4,Phase 2,Not Applicable
7 Antibodies Phase 4
8 Antibodies, Monoclonal Phase 4
9 Immunoglobulin Fab Fragments Phase 4
10 Immunoglobulins Phase 4
11
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
12
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
13
Ticlopidine Approved Phase 3 55142-85-3 5472
14 Analgesics Phase 3
15 Analgesics, Non-Narcotic Phase 3
16 Anti-Inflammatory Agents Phase 3
17 Anti-Inflammatory Agents, Non-Steroidal Phase 3
18 Antipyretics Phase 3
19 Antirheumatic Agents Phase 3
20 Cyclooxygenase Inhibitors Phase 3
21 Cytochrome P-450 Enzyme Inhibitors Phase 3
22 Neurotransmitter Agents Phase 3
23 Peripheral Nervous System Agents Phase 3
24 Purinergic P2 Receptor Antagonists Phase 3
25 Purinergic P2Y Receptor Antagonists Phase 3
26
Deferoxamine Approved, Investigational Phase 2 70-51-9 2973
27
Iron Approved Phase 2 7439-89-6 23925
28
Argatroban Approved, Investigational Phase 2 74863-84-6 152951
29
Serine Approved, Nutraceutical Phase 2 56-45-1 5951
30 Chelating Agents Phase 2
31 Iron Chelating Agents Phase 2
32 Pharmaceutical Solutions Phase 2
33 Antithrombin III Phase 2
34 Antithrombins Phase 2
35 HIV Protease Inhibitors Phase 2
36
protease inhibitors Phase 2
37 Serine Proteinase Inhibitors Phase 2
38
Warfarin Approved 81-81-2 6691 54678486
39
Menthol Approved Not Applicable 2216-51-5 16666
40 Dabigatran

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 A Randomized Double Blind Placebo Control Study of Huang-Chi-Wu-Wu- Tang in Patients With Intracranial Arterial Stenosis Unknown status NCT01553643 Phase 4 Chinese Herb Huang-Chi-Wu-Wu-Tang;placebo
2 Thrombectomy Under Reopro Versus Alteplase to Treat Stoke Terminated NCT02016547 Phase 4 alteplase 0.9mg/kg (10% by IV bolus following by 90% by 1 hour IV drip)
3 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Unknown status NCT01758614 Phase 3 Aspirin;Clopidogrel
4 Ultrasound Enhanced Thrombolytic Therapy of Middle Cerebral Artery Occlusion Unknown status NCT00336596 Phase 3
5 Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion Completed NCT00777140 Phase 2 Deferoxamine
6 Safety and Feasibility of Argatroban, Tissue Plasminogen Activator and Intra-arterial Therapy in Stroke Completed NCT02448069 Phase 2 Argatroban
7 Superiority of Rt-PA + Tenecteplase in Comparison With Rt-PA Only in Proximal Middle Cerebral Artery Occlusion Withdrawn NCT02338466 Phase 2 rt-PA;tenecteplase
8 Use of Hypothermia During Robotic Prostatectomy Unknown status NCT00915031 Not Applicable
9 Neurothrombectomy France Completed NCT02880579
10 The Comparative Safety and Effectiveness of Warfarin and Dabigatran Prescribed in the Non-valvular Atrial Fibrillation Population With Humana Healthcare Coverage Completed NCT02061748 Observational
11 Berlin PRehospital Or Usual Delivery of Acute Stroke Care Recruiting NCT02869386 Not Applicable
12 Embolectomy in Acute SYlvian Thrombosis in Refractory or Ineligible Patients to ALteplase Terminated NCT02216565 Not Applicable Alteplase if patient is eligible

Search NIH Clinical Center for Cerebral Artery Occlusion

Genetic Tests for Cerebral Artery Occlusion

Anatomical Context for Cerebral Artery Occlusion

MalaCards organs/tissues related to Cerebral Artery Occlusion:

41
Brain, Endothelial, Cortex, Bone, Bone Marrow, Spinal Cord, Thalamus

Publications for Cerebral Artery Occlusion

Articles related to Cerebral Artery Occlusion:

(show top 50) (show all 711)
# Title Authors Year
1
Progression of vasogenic edema induced by activated microglia under permanent middle cerebral artery occlusion. ( 29353043 )
2018
2
Middle Cerebral Artery Occlusion by an Intraluminal Suture Method. ( 29222799 )
2018
3
Dietary nitrate supplementation reduces low frequency blood pressure fluctuations in rats following distal middle cerebral artery occlusion. ( 29856262 )
2018
4
Acute Right Middle Cerebral Artery Occlusion Resulting in Acute Systolic Heart Failure, Cerebral T-Waves, and QTc Prolongation: A Case Report. ( 29953038 )
2018
5
Delayed Recanalization Promotes Functional Recovery in Rats Following Permanent Middle Cerebral Artery Occlusion. ( 29354887 )
2018
6
Ginkgolide K promotes angiogenesis in a middle cerebral artery occlusion mouse model via activating JAK2/STAT3 pathway. ( 29890157 )
2018
7
Effect of laser Doppler flowmetry and occlusion time on outcome variability and mortality in rat middle cerebral artery occlusion: inconclusive results. ( 29673328 )
2018
8
Intravenously Delivered Allogeneic Mesenchymal Stem Cells Bidirectionally Regulate Inflammation and Induce Neurotrophic Effects in Distal Middle Cerebral Artery Occlusion Rats Within the First 7 Days After Stroke. ( 29719282 )
2018
9
Neuronal loss and gliosis in the rat striatum subjected to 15 and 30 minutes of middle cerebral artery occlusion. ( 29354885 )
2018
10
The degree of leukoaraiosis predicts clinical outcomes and prognosis in patients with middle cerebral artery occlusion after intravenous thrombolysis. ( 29288062 )
2018
11
Epigallocatechin-3-Gallate Reduces Neuronal Apoptosis in Rats after Middle Cerebral Artery Occlusion Injury via PI3K/AKT/eNOS Signaling Pathway. ( 29770336 )
2018
12
Ischemic Stroke Detection by Analyzing Heart Rate Variability in Rat Middle Cerebral Artery Occlusion Model. ( 29877839 )
2018
13
MicroRNA-149-5p regulates blood-brain barrier permeability after transient middle cerebral artery occlusion in rats by targeting S1PR2 of pericytes. ( 29401609 )
2018
14
Hypoxic postconditioning enhances functional recovery following endothelin-1 induced middle cerebral artery occlusion in conscious rats. ( 29778441 )
2018
15
Licorice Pretreatment Protects Against Brain Damage Induced by Middle Cerebral Artery Occlusion in Mice. ( 29341803 )
2018
16
Electroacupuncture: a new approach to open the blood-brain barrier in rats recovering from middle cerebral artery occlusion. ( 29903719 )
2018
17
Identification of Proteins Differentially Expressed by Quercetin Treatment in a Middle Cerebral Artery Occlusion Model: A Proteomics Approach. ( 29926355 )
2018
18
Bilateral Middle Cerebral Artery Occlusion In Rapid Succession During Thrombolysis. ( 29623161 )
2018
19
Long non-coding RNA RMST silencing protects against middle cerebral artery occlusion (MCAO)-induced ischemic stroke. ( 29258823 )
2018
20
Citalopram attenuated neurobehavioral, biochemical, and metabolic alterations in transient middle cerebral artery occlusion model of stroke in male Wistar rats. ( 29656429 )
2018
21
Evidence from functional ultrasound imaging of enhanced contralesional microvascular response to somatosensory stimulation in acute middle cerebral artery occlusion/reperfusion in rats: A marker of ultra-early network reorganization? ( 29972329 )
2018
22
Comparison of therapeutic efficacy between isolated encephaloduroarteriosynangiosis and medical treatment in patients with atherosclerotic middle cerebral artery occlusion. ( 29935318 )
2018
23
Tirofiban combined with rt-PA intraarterial thrombolysis improves the recanalization rate of acute middle cerebral artery occlusion in rabbits. ( 29771445 )
2018
24
Dipyridamole plus Triflusal versus Triflusal Alone in Infarct Reduction after Middle Cerebral Artery Occlusion. ( 29338983 )
2018
25
Tail Vein Infusion of Adipose-Derived Mesenchymal Stem Cell Alleviated Inflammatory Response and Improved Blood Brain Barrier Condition by Suppressing Endoplasmic Reticulum Stress in a Middle Cerebral Artery Occlusion Rat Model. ( 29888735 )
2018
26
Mechanical Thrombectomy of Acute Middle Cerebral Artery Occlusion using Trans-Anterior Communicating Artery Approach. ( 29339323 )
2018
27
Protective effects of beef decoction rich in carnosine on cerebral ischemia injury by permanent middle cerebral artery occlusion in rats. ( 29399121 )
2018
28
Targeted Temperature Management at 33A^C or 36A^C Produces Equivalent Neuroprotective Effects in the Middle Cerebral Artery Occlusion Rat Model of Ischemic Stroke. ( 29337840 )
2018
29
Repeated Endovascular Treatment of Early Recurrent Proximal Middle Cerebral Artery Occlusion: Case Report and Brief Review of the Literature. ( 29774008 )
2018
30
Predictors of short-term outcome in patients with acute middle cerebral artery occlusion: unsuitability of fluid-attenuated inversion recovery vascular hyperintensity scores. ( 29451209 )
2018
31
Ischemia Reperfusion Injury after Gradual versus Rapid Flow Restoration for Middle Cerebral Artery Occlusion Rats. ( 29374244 )
2018
32
Myricetin against ischemic cerebral injury in rat middle cerebral artery occlusion model. ( 29257250 )
2018
33
Characterization of the transient middle cerebral artery occlusion model of ischemic stroke in a HuR transgenic mouse line. ( 29854897 )
2018
34
Thrombectomy for M1-Middle Cerebral Artery Occlusion: Angiographic Aspect of the Arterial Occlusion and Recanalization: A Preliminary Observation. ( 29618557 )
2018
35
The effect of exercise preconditioning on stroke outcome in ovariectomized mice with permanent middle cerebral artery occlusion. ( 28873322 )
2017
36
Metabolite changes in the ipsilateral and contralateral cerebral hemispheres in rats with middle cerebral artery occlusion. ( 28761426 )
2017
37
Hyperglycemia reduces PP2A subunit B expression in a middle cerebral artery occlusion animal model. ( 28652527 )
2017
38
Infiltration and persistence of lymphocytes during late-stage cerebral ischemia in middle cerebral artery occlusion and photothrombotic stroke models. ( 29246244 )
2017
39
Early Thrombectomy of a Proximal Middle Cerebral Artery Occlusion Leading to Complete Recovery with No Infarct. ( 28559829 )
2017
40
Spontaneous recanalization of atherosclerotic middle cerebral artery occlusion: Case report. ( 28682888 )
2017
41
Leptomeningeal collateral status predicts outcome after middle cerebral artery occlusion. ( 28905995 )
2017
42
Acute Cerebral Artery Occlusion by a Calcified Embolus with False Patency Sign on Computed Tomographic Angiography. ( 27789151 )
2017
43
Assessment of the Neuroprotective Effects of Arginine-Rich Protamine Peptides, Poly-Arginine Peptides (R12-Cyclic, R22) and Arginine-Tryptophan-Containing Peptides Following In Vitro Excitotoxicity and/or Permanent Middle Cerebral Artery Occlusion in Rats. ( 28523591 )
2017
44
Subacute endovascular recanalization of symptomatic cerebral artery occlusion: a propensity score-matched analysis. ( 28899866 )
2017
45
Transfusion of Polynitroxylated Pegylated Hemoglobin Stabilizes Pial Arterial Dilation and Decreases Infarct Volume After Transient Middle Cerebral Artery Occlusion. ( 28899897 )
2017
46
Safe time duration for temporary middle cerebral artery occlusion in aneurysm surgery based on motor-evoked potential monitoring. ( 28584682 )
2017
47
Infarct morphology assessment in patients with carotid artery/middle cerebral artery occlusion using fast fluid-attenuated inversion recovery (FLAIR) vascular hyperintensity (FVH). ( 29190679 )
2017
48
Successful Revascularization of Acute Middle Cerebral Artery Occlusion by Intravenous Thrombolysis While on Apixaban. ( 28615907 )
2017
49
Clinical Manifestations of Isolated Chronic Middle Cerebral Artery Occlusion in Relation to Angiographic Features. ( 28893698 )
2017
50
Quercetin attenuates the injury-induced reduction of I^-enolase expression in a middle cerebral artery occlusion animal model. ( 29399028 )
2017

Variations for Cerebral Artery Occlusion

Expression for Cerebral Artery Occlusion

Search GEO for disease gene expression data for Cerebral Artery Occlusion.

Pathways for Cerebral Artery Occlusion

Pathways related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.14 BDNF EPHA3 GDNF IL1B IL1RN NOS3
2
Show member pathways
13.09 BDNF EPHA3 IL1B NOS3 TNF
3
Show member pathways
13.02 GDNF HIF1A IL1B IL1RN TNF
4
Show member pathways
12.23 IL1B IL1RN NOS3
5
Show member pathways
12.18 HIF1A IL1B TNF
6
Show member pathways
11.9 IL1B IL1RN TNF
7 11.72 IL1B NOS3 TNF
8 11.6 HIF1A IL1B TNF
9 11.49 IL1B NOS3 TNF
10 11.34 BDNF GDNF IL1B TNF
11 11.25 IL1B TNF
12 11.23 BDNF HIF1A IL1B IL1RN TNF
13
Show member pathways
11.22 IL1B TNF
14 11.12 IL1B TNF
15 11.11 IL1B TNF
16 11.06 IL1B TNF
17 11.03 IL1B TNF
18 11.02 IL1B IL1RN TNF
19 11 IL1B TNF
20 10.87 HIF1A NOS3
21 10.8 IL1B TNF
22 10.64 IL1B TNF

GO Terms for Cerebral Artery Occlusion

Cellular components related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 BDNF EPHA3 GDNF IL1B IL1RN TNF

Biological processes related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.8 GDNF IL1B TNF
2 cytokine-mediated signaling pathway GO:0019221 9.76 HIF1A IL1B IL1RN TNF
3 positive regulation of angiogenesis GO:0045766 9.72 HIF1A IL1B NOS3
4 negative regulation of neuron apoptotic process GO:0043524 9.69 BDNF GDNF HIF1A
5 positive regulation of interferon-gamma production GO:0032729 9.63 IL1B TNF
6 positive regulation of nitric oxide biosynthetic process GO:0045429 9.62 IL1B TNF
7 neural crest cell migration GO:0001755 9.62 GDNF HIF1A
8 positive regulation of phagocytosis GO:0050766 9.61 IL1B TNF
9 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.61 IL1B TNF
10 positive regulation of interleukin-8 production GO:0032757 9.6 IL1B TNF
11 positive regulation of vascular endothelial growth factor production GO:0010575 9.59 HIF1A IL1B
12 peripheral nervous system development GO:0007422 9.58 BDNF GDNF
13 regulation of nitric-oxide synthase activity GO:0050999 9.58 IL1B NOS3
14 positive regulation of chemokine production GO:0032722 9.57 HIF1A TNF
15 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.56 HIF1A IL1B
16 negative regulation of lipid catabolic process GO:0050995 9.54 IL1B TNF
17 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.52 IL1B TNF
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.49 IL1B TNF
19 positive regulation of chemokine biosynthetic process GO:0045080 9.48 IL1B TNF
20 regulation of establishment of endothelial barrier GO:1903140 9.43 IL1B TNF
21 positive regulation of fever generation GO:0031622 9.4 IL1B TNF
22 fever generation GO:0001660 9.37 IL1B IL1RN
23 regulation of signaling receptor activity GO:0010469 9.35 BDNF GDNF IL1B IL1RN TNF
24 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.33 GDNF IL1B TNF
25 sequestering of triglyceride GO:0030730 9.32 IL1B TNF
26 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 IL1B TNF
27 lipopolysaccharide-mediated signaling pathway GO:0031663 8.8 IL1B NOS3 TNF

Molecular functions related to Cerebral Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL1B IL1RN TNF
2 interleukin-1 receptor binding GO:0005149 8.62 IL1B IL1RN

Sources for Cerebral Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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