Cerebral Atherosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Cerebral Atherosclerosis

MalaCards integrated aliases for Cerebral Atherosclerosis:

Name: Cerebral Atherosclerosis 12 54 15 17 70 32
Intracranial Arteriosclerosis 44 70


External Ids:

Disease Ontology 12 DOID:12720
ICD9CM 34 437.0
MeSH 44 D002537
NCIt 50 C34459
SNOMED-CT 67 266258005
ICD10 32 I67.2
UMLS 70 C0007771 C0007775

Summaries for Cerebral Atherosclerosis

MalaCards based summary : Cerebral Atherosclerosis, also known as intracranial arteriosclerosis, is related to atherosclerosis susceptibility and mild cognitive impairment. An important gene associated with Cerebral Atherosclerosis is APOE (Apolipoprotein E), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Selenium Micronutrient Network. The drugs Atorvastatin and Cilostazol have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and smooth muscle.

Wikipedia : 73 Cerebral atherosclerosis is a type of atherosclerosis where build-up of plaque in the blood vessels of... more...

Related Diseases for Cerebral Atherosclerosis

Diseases related to Cerebral Atherosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 222)
# Related Disease Score Top Affiliating Genes
1 atherosclerosis susceptibility 30.6 MTHFR CRP APOE APOB APOA1 ACE
2 mild cognitive impairment 30.1 MTHFR APOE ACE
3 arteriolosclerosis 30.0 SERPINA3 APOE
4 hypercholesterolemia, familial, 1 29.9 CRP APOE APOB APOA1 ACE
5 homocysteinemia 29.9 MTHFR CRP APOE
6 angina pectoris 29.9 CRP APOA1 ACE
7 arteriosclerosis 29.9 CRP APOE APOB APOA1 ACE
8 homozygous familial hypercholesterolemia 29.8 APOE APOB APOA1
9 vascular disease 29.7 MTHFR CRP APOE APOB APOA1 ACE
10 carotid stenosis 29.7 MTHFR CRP APOE ACE
11 moyamoya disease 1 29.6 RNF213 MTHFR CRP
12 sleep apnea 29.5 CRP APOE APOB ACE
13 vascular dementia 29.4 SERPINA3 MTHFR CRP APOE ACE
14 cerebrovascular disease 29.4 SERPINA3 MTHFR CRP APOE APOB APOA1
15 coronary heart disease 1 29.3 CRP APOE APOB APOA1 ACE
16 carotid artery disease 29.3 CRP APOE APOB APOA1 ACE
17 peripheral vascular disease 29.3 MTHFR CRP APOB APOA1 ACE
18 stroke, ischemic 29.2 SERPINA3 MTHFR CRP APOE APOB ACE
19 familial hypercholesterolemia 29.1 MTHFR CRP APOE APOB APOA1 ACE
20 arteries, anomalies of 29.0 SERPINA3 CRP APOE APOB APOA1 ACE
21 lipoprotein quantitative trait locus 28.8 SERPINA3 MTHFR CRP APOE APOB APOA1
22 intracranial arteriosclerosis 11.4
23 moderate and severe traumatic brain injury 10.4 APOE ACE
24 arteritic anterior ischemic optic neuropathy 10.4 MTHFR ACE
25 familial lcat deficiency 10.4 APOE APOA1
26 hepatic lipase deficiency 10.4 APOE APOA1
27 lateral myocardial infarction 10.3 MTHFR ACE
28 idiopathic nephrotic syndrome 10.3 APOE ACE
29 acute dacryoadenitis 10.3 CRP ACE
30 intracranial vasospasm 10.3 MTHFR APOE ACE
31 mediastinum teratoma 10.3 CRP ACE
32 cardiac tuberculosis 10.3 CRP ACE
33 anterior scleritis 10.3 CRP ACE
34 lemierre's syndrome 10.3 MTHFR CRP
35 multiple cranial nerve palsy 10.3 CRP ACE
36 cranial nerve palsy 10.3 CRP ACE
37 posterior scleritis 10.3 CRP ACE
38 tolosa-hunt syndrome 10.3 CRP ACE
39 chronic orbital inflammation 10.3 CRP ACE
40 intracranial sinus thrombosis 10.3 MTHFR CRP
41 xanthoma disseminatum 10.2 APOE APOB
42 glossopharyngeal nerve disease 10.2 CRP ACE
43 granulomatous angiitis 10.2 CRP ACE
44 urinary tract infection 10.2 CRP ACE
45 neuroretinitis 10.2 CRP ACE
46 cholesterol embolism 10.2 CRP ACE
47 optic papillitis 10.2 CRP ACE
48 defective apolipoprotein b-100 10.2 APOE APOB
49 asplenia, isolated congenital 10.2
50 granulomatous hepatitis 10.2 CRP ACE

Comorbidity relations with Cerebral Atherosclerosis via Phenotypic Disease Network (PDN): (show all 40)

Active Peptic Ulcer Disease Acute Cystitis
Alzheimer Disease Aortic Valve Disease 1
Basilar Artery Insufficiency Benign Essential Hypertension
Borderline Personality Disorder Bronchitis
Bronchopneumonia Cerebral Degeneration
Cerebrovascular Disease Chronic Kidney Disease
Decubitus Ulcer Deficiency Anemia
Encephalopathy Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Hypertensive Encephalopathy Hypoglycemia
Hypothyroidism Intracranial Embolism
Intracranial Thrombosis Iron Deficiency Anemia
Major Depressive Disorder Malignant Essential Hypertension
Osteoporosis Parkinson Disease, Late-Onset
Peripheral Vascular Disease Protein-Energy Malnutrition
Pseudobulbar Palsy Schizophreniform Disorder
Sinoatrial Node Disease Status Epilepticus
Swallowing Disorders Transient Cerebral Ischemia
Vascular Dementia Vertebral Artery Insufficiency

Graphical network of the top 20 diseases related to Cerebral Atherosclerosis:

Diseases related to Cerebral Atherosclerosis

Symptoms & Phenotypes for Cerebral Atherosclerosis

Drugs & Therapeutics for Cerebral Atherosclerosis

Drugs for Cerebral Atherosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 101)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Atorvastatin Approved Phase 4 134523-00-5 60823
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
Atenolol Approved Phase 4 29122-68-7 2249
Propranolol Approved, Investigational Phase 4 525-66-6 4946
tannic acid Approved Phase 4 1401-55-4
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
Phenylpropanolamine Approved, Vet_approved, Withdrawn Phase 4 14838-15-4 26934
Probucol Approved, Investigational Phase 4 23288-49-5 4912
Evolocumab Approved Phase 4 1256937-27-5
13 Rosuvastatin Calcium Phase 4 147098-20-2
14 Vasodilator Agents Phase 4
15 Respiratory System Agents Phase 4
16 Anti-Asthmatic Agents Phase 4
17 Phosphodiesterase 3 Inhibitors Phase 4
18 Phosphodiesterase Inhibitors Phase 4
19 Neuroprotective Agents Phase 4
20 Protective Agents Phase 4
21 Bronchodilator Agents Phase 4
22 Neurotransmitter Agents Phase 4
23 HIV Protease Inhibitors Phase 4
protease inhibitors Phase 4
25 Adrenergic beta-Antagonists Phase 4
26 Anti-Arrhythmia Agents Phase 4
27 Angiotensin-Converting Enzyme Inhibitors Phase 4
28 Cardiotonic Agents Phase 4
29 Adrenergic Antagonists Phase 4
30 Adrenergic Agents Phase 4
31 Adrenergic beta-1 Receptor Antagonists Phase 4
32 Sympatholytics Phase 4
33 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
34 Hormones Phase 4
35 Calcium, Dietary Phase 4
36 Antimetabolites Phase 4
37 Anticholesteremic Agents Phase 4
38 Hypolipidemic Agents Phase 4
39 Lipid Regulating Agents Phase 4
40 Antihypertensive Agents Phase 4
Calcium Nutraceutical Phase 4 7440-70-2 271
Colestipol Approved Phase 3 26658-42-4
Nicotinamide Approved, Investigational Phase 3 98-92-0 936
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
Niacin Approved, Investigational, Nutraceutical Phase 3 59-67-6 938
46 Vitamin B9 Phase 3
47 Vitamin B3 Phase 3
48 Folate Phase 3
49 Vitamin B Complex Phase 3
50 Nicotinic Acids Phase 3

Interventional clinical trials:

(show all 44)
# Name Status NCT ID Phase Drugs
1 Intensive Statin Treatment in Acute Ischemic Stroke Patients With INtracranial Atherosclerosis - High-Resolution Magnetic Resonance Imaging Study (STAMINA-MRI Study) Unknown status NCT02458755 Phase 4 High-dose statin: Atorvastatin 40mg or Rosuvastatin 20mg
2 Multicenter Double-blind Placebo-controlled Parallel-group Randomized Clinical Trial of Efficacy and Safety of Divaza in the Management of Oxidative Disturbances in Cerebral Atherosclerosis Completed NCT03485495 Phase 4 Divaza;Placebo
3 A Randomized, Control, Open Label, Multicentre Clinical Study to Evaluate the Efficacy and Safety of Cilostazol and Probucol Alone and in Combination on Atherosclerosis Related Biomarker---atherosclerosis Cerebral Infarction Patient as Study Subject Completed NCT00823875 Phase 4 Cilostazol group;Probucol group;Cilostazol + Probucol group;control group
4 Reducing Total Cardiovascular Risk in an Urban Community Completed NCT00241904 Phase 4 Antiplatelet Agents;Beta Blocker;ACE Inhibitors
5 The Effect of InTensive Statin in Ischemic Stroke With inTracranial Atherosclerotic Plaques: a Prospective, Random, Single-center Study Based on High Resolution Magnetic Resonance Imaging Recruiting NCT03753555 Phase 4 Atorvastatin Calcium;Atorvastatin Calcium;Probucol
6 Reducing Intracranial atheroSclErosis With Repatha Not yet recruiting NCT04573777 Phase 4 Repatha
7 Multicenter Clinical Trial for Development of Guidelines of Adequate Blood Pressure Lowering in the Subacute Ischemic Stroke Patients Due to Intracranial Atherosclerosis Terminated NCT01104311 Phase 4
8 Study of Urinary Kallikrein to Enhance Collateral Circulation in Symptomatic Intracranial Atherosclerosis: a Study Based on Whole-brain CTP Withdrawn NCT04325932 Phase 4 Urinary Kallikrein
9 Angioplasty and Stenting for Patients With Symptomatic Intracranial Atherosclerosis: Study Protocol of a Randomized Controlled Trial Unknown status NCT02689037 Phase 3 Aspirin plus clopidogrel
10 The Impact of Repeated Bilateral Limb Remote Ischemic Conditioning on Patients With Chronic Cerebral Ischemia: Establishment of Optimized Algorithm on the Basis of Feasibility, Safety and Efficacy Unknown status NCT03105141 Phase 2, Phase 3
11 Cilostazol-Aspirin Therapy Against Recurrent Stroke With Intracranial Artery Stenosis (CATHARSIS) Completed NCT00333164 Phase 3 Asprin, Cilostazol
12 Cholesterol-Lowering Atherosclerosis Study (CLAS) Completed NCT00000599 Phase 3 colestipol;niacin
13 Prevention for the Restenosis of Intracranial Artery Stent Implantation Treated With Herbal Medicine C117--PRISIT Trial Unknown status NCT03008798 Phase 2 Herbal Medicine C-117;The Placebo of Herbal Medicine C-117
14 Asymptomatic Carotid Artery Plaque Study (ACAPS) Completed NCT00000469 Phase 2 aspirin;lovastatin
15 Antioxidants and Prevention of Early Atherosclerosis Terminated NCT00000600 Phase 2 Vitamin E;Vitamin C
16 A Single/Multiple Ascending Dose Phase 1 Study of the Safety, Tolerability and Pharmacologic Activity of BT200 in Normal Human Volunteers Completed NCT04103034 Phase 1 BT200;Desmopressin;Placebo
17 Treatment Targets for Inflamed Intracranial Atherosclerosis on Vessel Wall MRI Enrolling by invitation NCT03084523 Phase 1 Ferumoxytol Injectable Product
18 Vessel Wall and Perfusion Imaging in Intracranial Atherosclerosis Unknown status NCT02719652
19 Wingspan Stenting for Symptomatic Severe Stenosis of Intracranial Atherosclerosis Registry in China Unknown status NCT00685308
20 Remote Ischemic Conditioning for Avoiding Recurrence of Ischemic Stroke in Patients With Symptomatic Intracranial Atherosclerotic Stenosis Unknown status NCT02534545
21 Clinical Trail of Hybrid Operating Technique in Management of Intracranial Aneurysms With Coexistence of Atherosclerotic Intracranial Arterial Stenosis Unknown status NCT03204435
22 Stroke Imaging Package Study Completed NCT02485275
23 An International Registry of the Wingspan™ Stent System for the Treatment of Intracranial Atherosclerotic Stenosis Completed NCT00929383
24 WEAVE™ Trial: Wingspan StEnt System Post MArket SurVEillance Study Completed NCT02034058
25 Identification of the Antiplatelet Compounds of Garlic Ex Vivo Completed NCT00200785
26 Epidemiology of Vascular Inflammation & Atherosclerosis Completed NCT00087893
27 Boston Scientific EPI: A Carotid Stenting Trial for High-Risk Surgical Patients Completed NCT00316108
28 Gene-by-Smoking Interactions and Risk of Atherosclerosis - Ancillary to ARIC Completed NCT00064545
29 Intracranial Atherosclerosis and Predictors of Post-CABG Depression Completed NCT01838356
30 EDAS (Surgical) Revascularization for Symptomatic Intracranial Arterial Stenosis Completed NCT01819597
31 Asymptomatic Intracranial Atherosclerotic Disease: Prevalence, Clinical and Lifestyle Determinants in Urban Pakistan Completed NCT02072876
32 Pilot Study of Pre-Ischemic Conditioning for Intracranial Atherosclerosis Completed NCT03208166
33 Coexistence of Cerebral and Coronary Atherosclerosis in Acute Ischemic Cerebrovascular Disease Patients Registry Recruiting NCT03788512
34 Stroke Imaging Package Study of Intracranial Atherosclerosis Recruiting NCT03719820 aggressive medical management
35 The Role of Additional Antiplatelet Therapy in the Ischemic Stroke With Atrial Fibrillation and Co-morbiD Atherosclerosis During edOxaban treatmeNt. (ADD-ON) Study, Multicenter Registry-based Analysis Recruiting NCT04010955 Edoxaban Monotherapy
36 Vessel Wall MR Imaging to Explore Sex-Differences of Intracranial Arterial Wall Changes After Suspected Stroke Recruiting NCT03990545
37 Morphology of Advanced Symptomatic Cerebral Plaques With High Embolic Potential Recruiting NCT03291652
38 CUHK Stroke Biobank Recruiting NCT03291392
39 Morphologic Evolution and Remodeling of Intracranial Atherosclerosis: A Longitudinal Study by 3D-rotational Angiography Recruiting NCT03295773
40 Study on Prevention and Treatment of Atherosclerotic Cerebral Occlusive Disease With Remote Ischemic Conditioning Not yet recruiting NCT04470492 Medical Management
41 Evaluation of the Safety and Efficacy of Drug Eluting Balloon Catheter for the Treatment of Patients With Symptomatic Intracranial Atherosclerosis Stenosis Not yet recruiting NCT04821726
42 A Prospective, Multicenter, Randomized Controlled Clinical Trial to Evaluate the Efficacy and Safety of Intracranial Drug-coated Balloon Catheters in the Treatment of Symptomatic Intracranial Atherosclerotic de Novo Stenosis Not yet recruiting NCT04631055
43 A Prospective, Multi-center, Randomized Controlled Trial to Evaluate the Safety and Feasibility of Intracranial Drug-coated Balloon Catheter in the Treatment of Intracranial In-stent Restenosis Not yet recruiting NCT04627870
44 PCSK9 Inhibition in Patients With Symptomatic Intracranial Atherosclerosis Terminated NCT03507374 Early Phase 1 Alirocumab;Placebo

Search NIH Clinical Center for Cerebral Atherosclerosis

Cochrane evidence based reviews: intracranial arteriosclerosis

Genetic Tests for Cerebral Atherosclerosis

Anatomical Context for Cerebral Atherosclerosis

MalaCards organs/tissues related to Cerebral Atherosclerosis:

Brain, Heart, Smooth Muscle, Endothelial, Cortex, Kidney, Adrenal Cortex

Publications for Cerebral Atherosclerosis

Articles related to Cerebral Atherosclerosis:

(show top 50) (show all 556)
# Title Authors PMID Year
[Sensitivity of atherosclerosis indices in patients with ischemic brain disease]. 54 61
8560842 1994
Association of Bone Mineral Density to Cerebral Small Vessel Disease Burden. 61
33431517 2021
Decreased 18F-Fluorodeoxyglucose Uptake in Lumbar Vertebrae of Stroke Patients. 61
33480197 2021
Chronic Periodontitis is Associated With Cerebral Atherosclerosis -A Nationwide Study. 61
33304705 2020
Role of activin receptor-like kinase 1 in vascular development and cerebrovascular diseases. 61
32246621 2020
Inappropriate use of antiplatelet agents for primary prevention in nursing homes: An Italian multicenter observational study. 61
32716596 2020
Publisher Correction: Shared proteomic effects of cerebral atherosclerosis and Alzheimer's disease on the human brain. 61
32576978 2020
Shared proteomic effects of cerebral atherosclerosis and Alzheimer's disease on the human brain. 61
32424284 2020
Cerebral atherosclerosis and early ischemic stroke after left-sided valve replacement surgery. 61
32616350 2020
Association between Plasma Adipocytokines Levels and Intracranial versus Extracranial Atherosclerotic among Chinese Patients with Stroke. 61
32548044 2020
Comparison of Prediction Models based on Risk Factors and Retinal Characteristics Associated with Recurrence One Year after Ischemic Stroke. 61
31928865 2020
32383700 2020
Distribution of cerebral artery stenosis and risk factors in ethnic Zhuang and Han patients with ischemic stroke in Guangxi province. 61
32156133 2020
Plasma RANTES level is correlated with cardio-cerebral atherosclerosis burden in patients with ischemic cerebrovascular disease. 61
32226934 2020
Circular RNA circ_0003204 inhibits proliferation, migration and tube formation of endothelial cell in atherosclerosis via miR-370-3p/TGFβR2/phosph-SMAD3 axis. 61
31900142 2020
[Incidence of postoperative cognitive dysfunction after simultaneous carotid surgery and coronary artery bypass grafting in patients with asymptomatic cerebral atherosclerosis]. 61
32307423 2020
Plasma Fibroblast Growth Factor 23 Concentration Is Associated with Intracranial Cerebral Atherosclerosis in Acute Ischemic Stroke Patients. 61
31942755 2020
[Prospects of clinical application of cilostazol for peripheral artery disease]. 61
33063749 2020
Coronary Calcium Score for the Prediction of Asymptomatic Coronary Artery Disease in Patients With Ischemic Stroke. 61
32292387 2020
Are Genetic Variants Associated with the Location of Cerebral Arterial Lesions in Stroke Patients? 61
32526736 2020
A cross-sectional feasibility study of neurovascular ultrasound in Malawian adults with acute stroke-like syndrome. 61
32032392 2020
[Expanding the possibilities of antithrombotic therapy of cerebrovascular pathology]. 61
32490629 2020
Late-Onset Wilson's Disease. 61
32118011 2020
The characterization of headache in patients with dyscirculatory encephalopathy of different genesis. 61
32723961 2020
Cognitive disorders in persons of working age with dyscirculatory encephalopathy. 61
32285811 2020
Effects of lncRNA gm4419 on rats with hypertensive cerebral atherosclerosis through NF-κB pathway. 61
31858567 2019
Subclinical Peripheral Arterial Disease in Patients with Acute Ischemic Stroke: A Study with Ultrasonography. 61
31522885 2019
Correlation between Metabolic Syndrome and Intracranial versus Extracranial Arteriosclerosis among Chinese Patients with Stroke. 61
31970098 2019
A Comprehensive Assessment of Vascular and Nonvascular Risk Factors Associated with Migraine. 61
31890393 2019
[Association between soluble receptor for advanced glycation end products (sRAGE) and coronary and cerebral atherosclerosis]. 61
31648447 2019
Serum Aldosterone Is Associated with Cerebral Artery Atherosclerosis and Calcification. 61
30528672 2019
[Applications of cerebral bypass surgery in modern neurosurgery]. 61
30931883 2019
Cigarette Smoking Preferentially Affects Intracranial Vessels in Young Males: A Propensity-Score Matching Analysis. 61
30827064 2019
A Simple Scoring Model for Prediction of Rupture Risk of Anterior Communicating Artery Aneurysms. 61
31214103 2019
Successful Endovascular Bailout Strategy for Retained Accunet Embolic Protection Device During Vertebral Artery Stenting. 61
30915017 2019
Characteristics and Factors for Short-Term Functional Outcome in Stroke Patients With Atrial Fibrillation, Nationwide Retrospective Cohort Study. 61
31681159 2019
Antiphospholipid Antibodies: Cognitive and Motor Decline, Neuroimaging and Neuropathology. 61
31067547 2019
Plasma miR-126 and miR-143 as Potential Novel Biomarkers for Cerebral Atherosclerosis. 61
30309729 2019
Intracranial Arterial Calcificationes Can Reflect Cerebral Atherosclerosis Burden. 61
30375758 2019
Width of sulcus and thickness of gyrus in patients with cerebral atherosclerosis: a new tool for the prevention of vascular cognitive impairment. 61
30673038 2018
Computed Tomography Angiography Evaluation of Risk Factors for Unstable Intracranial Aneurysms. 61
29567291 2018
Increase in perfused boundary region of endothelial glycocalyx is associated with higher prevalence of ischemic heart disease and lesions of microcirculation and vascular wall. 61
29608790 2018
Cerebrovascular Reactivity and Carotid Intima-Media Thickness in Opium Dependents: A Case-Control Study. 61
31069037 2018
Risk Factors for the Rupture of Intracranial Aneurysms Using Computed Tomography Angiography. 61
29129762 2018
The Prevalence and Distribution of Occlusive Lesions of the Cerebral Arteries in Patients Undergoing Coronary Artery Bypass Graft Surgery. 61
29518536 2018
Risk factors for ruptured intracranial aneurysms. 61
29749361 2018
Role of Noninvasive Imaging of Cerebral Arterial System in Ischemic Stroke: Comparison of Transcranial Color-coded Doppler Sonography with Magnetic Resonance Angiography. 61
29770267 2018
Association Between Net Vertebral Artery Flow Volume and Non-AF Stroke: A Retrospective 2-Year Analysis. 61
30713522 2018
[Clinical features of ischaemic stroke with cerebral venous insufficiency and its risk factors.] 61
30080335 2018
Association of Homocysteine with Aysmptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients. 61
29330520 2018

Variations for Cerebral Atherosclerosis

Expression for Cerebral Atherosclerosis

Search GEO for disease gene expression data for Cerebral Atherosclerosis.

Pathways for Cerebral Atherosclerosis

Pathways related to Cerebral Atherosclerosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
Show member pathways
Show member pathways
5 10.7 APOB APOA1

GO Terms for Cerebral Atherosclerosis

Cellular components related to Cerebral Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.03 SERPINA3 MIR660 MIR1306 CRP APOE APOB
2 blood microparticle GO:0072562 9.63 SERPINA3 APOE APOA1
3 high-density lipoprotein particle GO:0034364 9.54 APOE APOB APOA1
4 very-low-density lipoprotein particle GO:0034361 9.5 APOE APOB APOA1
5 endocytic vesicle lumen GO:0071682 9.43 APOE APOB APOA1
6 discoidal high-density lipoprotein particle GO:0034365 9.4 APOE APOA1
7 low-density lipoprotein particle GO:0034362 9.33 APOE APOB APOA1
8 chylomicron GO:0042627 9.13 APOE APOB APOA1
9 intermediate-density lipoprotein particle GO:0034363 8.8 APOE APOB APOA1

Biological processes related to Cerebral Atherosclerosis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 lipid transport GO:0006869 9.8 APOE APOB APOA1
2 steroid metabolic process GO:0008202 9.79 APOE APOB APOA1
3 cholesterol metabolic process GO:0008203 9.76 APOE APOB APOA1
4 cholesterol homeostasis GO:0042632 9.74 APOE APOB APOA1
5 retinoid metabolic process GO:0001523 9.65 APOE APOB APOA1
6 cholesterol transport GO:0030301 9.63 APOB APOA1
7 positive regulation of cholesterol efflux GO:0010875 9.63 APOE APOA1
8 positive regulation of lipid biosynthetic process GO:0046889 9.61 APOE APOA1
9 reverse cholesterol transport GO:0043691 9.61 APOE APOA1
10 high-density lipoprotein particle remodeling GO:0034375 9.6 APOE APOA1
11 low-density lipoprotein particle remodeling GO:0034374 9.59 APOE APOB
12 high-density lipoprotein particle assembly GO:0034380 9.58 APOE APOA1
13 intermembrane lipid transfer GO:0120009 9.58 APOE APOB APOA1
14 phospholipid efflux GO:0033700 9.56 APOE APOA1
15 high-density lipoprotein particle clearance GO:0034384 9.55 APOE APOA1
16 very-low-density lipoprotein particle remodeling GO:0034372 9.54 APOE APOA1
17 positive regulation of cholesterol esterification GO:0010873 9.52 APOE APOA1
18 chylomicron remnant clearance GO:0034382 9.51 APOE APOB
19 cholesterol efflux GO:0033344 9.5 APOE APOB APOA1
20 regulation of Cdc42 protein signal transduction GO:0032489 9.49 APOE APOA1
21 very-low-density lipoprotein particle clearance GO:0034447 9.46 APOE APOB
22 lipoprotein catabolic process GO:0042159 9.43 APOE APOB
23 lipoprotein metabolic process GO:0042157 9.43 APOE APOB APOA1
24 positive regulation of phospholipid efflux GO:1902995 9.37 APOE APOA1
25 chylomicron assembly GO:0034378 9.33 APOE APOB APOA1
26 chylomicron remodeling GO:0034371 9.13 APOE APOB APOA1
27 lipoprotein biosynthetic process GO:0042158 8.8 APOE APOB APOA1

Molecular functions related to Cerebral Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipid binding GO:0005543 9.54 APOE APOB APOA1
2 lipid transporter activity GO:0005319 9.33 APOE APOB APOA1
3 lipoprotein particle binding GO:0071813 9.32 APOE APOA1
4 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.26 APOE APOA1
5 low-density lipoprotein particle receptor binding GO:0050750 9.13 CRP APOE APOB
6 intermembrane cholesterol transfer activity GO:0120020 8.8 APOE APOB APOA1

Sources for Cerebral Atherosclerosis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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