MCID: CRB008
MIFTS: 41

Cerebral Atherosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Cerebral Atherosclerosis

MalaCards integrated aliases for Cerebral Atherosclerosis:

Name: Cerebral Atherosclerosis 12 55 15 73
Intracranial Arteriosclerosis 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12720
ICD10 33 I67.2
ICD9CM 35 437.0
MeSH 44 D002537
NCIt 50 C34459
SNOMED-CT 68 55382008

Summaries for Cerebral Atherosclerosis

MalaCards based summary : Cerebral Atherosclerosis, also known as intracranial arteriosclerosis, is related to stroke, ischemic and sleep apnea. An important gene associated with Cerebral Atherosclerosis is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Selenium Micronutrient Network. The drugs Cilostazol and Probucol have been mentioned in the context of this disorder. Affiliated tissues include brain, smooth muscle and heart, and related phenotypes are Increased LDL uptake and cardiovascular system

Wikipedia : 76 Cerebral atherosclerosis is a type of atherosclerosis where build-up of plaque in the blood vessels of... more...

Related Diseases for Cerebral Atherosclerosis

Diseases related to Cerebral Atherosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 stroke, ischemic 30.1 ACE APOE MTHFR
2 sleep apnea 29.6 ACE APOE
3 heart disease 29.5 ACE APOA1 APOE MTHFR
4 hypercholesterolemia, familial 29.5 ACE APOA1 APOE
5 ischemic heart disease 29.3 ACE APOA1 APOE MTHFR
6 cerebrovascular disease 29.3 ACE APOA1 APOE MTHFR
7 vascular disease 29.3 ACE APOA1 APOE MTHFR
8 coronary heart disease 1 29.3 ACE APOA1 APOE MTHFR
9 intracranial arteriosclerosis 12.3
10 moderate and severe traumatic brain injury 10.1 ACE APOE
11 generalized atherosclerosis 10.1 ACE APOE
12 retinal artery occlusion 10.1 ACE MTHFR
13 arteritic anterior ischemic optic neuropathy 10.1 ACE MTHFR
14 ischemic optic neuropathy 10.1 ACE MTHFR
15 aortic atherosclerosis 10.1 ACE APOE
16 exfoliation syndrome 10.1 APOE MTHFR
17 nephrosclerosis 10.1 ACE MTHFR
18 hemorrhage, intracerebral 10.1 ACE APOE
19 familial lcat deficiency 10.1 APOA1 APOE
20 nonarteritic anterior ischemic optic neuropathy 10.1 ACE MTHFR
21 hepatic lipase deficiency 10.1 APOA1 APOE
22 hyperlipoproteinemia, type v 10.1 APOA1 APOE
23 leukodystrophy, hypomyelinating, 3 10.1 APOA1 APOE
24 retinal vascular disease 10.1 ACE MTHFR
25 hypolipoproteinemia 10.1 APOA1 APOE
26 hypertriglyceridemia, familial 10.1 APOA1 APOE
27 hyperlipoproteinemia, type iii 10.1 APOA1 APOE
28 arcus corneae 10.1 APOA1 APOE
29 hyperalphalipoproteinemia 1 10.1 APOA1 APOE
30 lecithin:cholesterol acyltransferase deficiency 10.1 APOA1 APOE
31 abetalipoproteinemia 10.0 APOA1 APOE
32 migraine with aura 10.0 ACE MTHFR
33 inherited metabolic disorder 10.0 APOA1 MTHFR
34 tangier disease 10.0 APOA1 APOE
35 gallbladder disease 10.0 APOA1 APOE
36 cerebral palsy 10.0 APOE MTHFR
37 peripheral vascular disease 10.0 ACE APOA1
38 carotid stenosis 10.0 ACE APOE MTHFR
39 vascular dementia 10.0 ACE APOE MTHFR
40 familial hyperlipidemia 10.0 APOA1 APOE
41 aortic aneurysm, familial abdominal, 1 10.0 ACE APOE
42 fibromuscular dysplasia 10.0 ACE RNF213
43 alzheimer disease 9.9
44 atherosclerosis susceptibility 9.9
45 coronary stenosis 9.9 ACE APOA1 APOE
46 carotid artery disease 9.9 ACE APOA1 APOE
47 arteries, anomalies of 9.9 ACE APOA1 APOE
48 lipid metabolism disorder 9.9 ACE APOA1 APOE
49 arteriosclerosis 9.9 ACE APOA1 APOE
50 cerebral arterial disease 9.9 RNF213 RPSA

Comorbidity relations with Cerebral Atherosclerosis via Phenotypic Disease Network (PDN): (show all 42)


Active Peptic Ulcer Disease Acute Cystitis
Alzheimer Disease Aortic Valve Disease 1
Basilar Artery Insufficiency Benign Essential Hypertension
Borderline Personality Disorder Bronchitis
Bronchopneumonia Cerebral Degeneration
Cerebrovascular Disease Chronic Kidney Failure
Chronic Myocardial Ischemia Decubitus Ulcer
Deficiency Anemia Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hypertensive Encephalopathy
Hypoglycemia Hypothyroidism
Intracranial Embolism Intracranial Thrombosis
Iron Deficiency Anemia Ischemic Heart Disease
Major Depressive Disorder Malignant Essential Hypertension
Osteoporosis Parkinson Disease, Late-Onset
Peripheral Vascular Disease Protein-Energy Malnutrition
Pseudobulbar Palsy Schizophreniform Disorder
Sinoatrial Node Disease Status Epilepticus
Swallowing Disorders Transient Cerebral Ischemia
Vascular Dementia Vertebral Artery Insufficiency

Graphical network of the top 20 diseases related to Cerebral Atherosclerosis:



Diseases related to Cerebral Atherosclerosis

Symptoms & Phenotypes for Cerebral Atherosclerosis

GenomeRNAi Phenotypes related to Cerebral Atherosclerosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased LDL uptake GR00340-A-1 8.62 APOA1 APOE

MGI Mouse Phenotypes related to Cerebral Atherosclerosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.55 ACE APOA1 APOE RNF213 RPSA
2 endocrine/exocrine gland MP:0005379 9.35 ACE APOA1 APOE RNF213 RPSA
3 liver/biliary system MP:0005370 8.92 ACE APOA1 APOE MTHFR

Drugs & Therapeutics for Cerebral Atherosclerosis

Drugs for Cerebral Atherosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
2
Probucol Approved, Investigational Phase 4 23288-49-5 4912
3
Amlodipine Approved Phase 4 88150-42-9 2162
4
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
5
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
6 Fibrinolytic Agents Phase 4
7 Vasodilator Agents Phase 4
8 Phosphodiesterase 3 Inhibitors Phase 4
9 Antioxidants Phase 4
10 Platelet Aggregation Inhibitors Phase 4
11 Autonomic Agents Phase 4
12 Peripheral Nervous System Agents Phase 4
13 Bronchodilator Agents Phase 4
14 Respiratory System Agents Phase 4
15 Anti-Asthmatic Agents Phase 4
16 Antimetabolites Phase 4
17 Anticholesteremic Agents Phase 4
18 Protective Agents Phase 4
19 Hypolipidemic Agents Phase 4
20 Lipid Regulating Agents Phase 4
21 Neuroprotective Agents Phase 4
22 Phosphodiesterase Inhibitors Phase 4
23 Antihypertensive Agents Phase 4
24 calcium channel blockers Phase 4
25 Calcium, Dietary Phase 4
26 Angiotensin II Type 1 Receptor Blockers Phase 4
27 Angiotensinogen Phase 4
28 Angiotensin Receptor Antagonists Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Cilostazol and Probucol Alone and in Combination on Atherosclerosis Related Biomarker---atherosclerosis Cerebral Infarction Patient as Study Subject Completed NCT00823875 Phase 4 Cilostazol group;Probucol group;Cilostazol + Probucol group;control group
2 Trial Comparing Metabolic Effects of Telmisartan and Amlodipine on Hypertensive Patients With Obesity and Diabetes Completed NCT00847262 Phase 4 Temisartan;Amlodipine
3 Clinical Trial of Efficacy and Safety of Divaza in the Management of Oxidative Disturbances in Cerebral Atherosclerosis Active, not recruiting NCT03485495 Phase 4 Divaza;Placebo
4 Combined Coronary and Cerebral Angiography and Intervention for Coronary and Cerebrovascular Atherosclerosis Unknown status NCT02315924 Not Applicable
5 Coexistence of Cerebral and Coronary Atherosclerosis in Acute Ischemic Cerebrovascular Disease Patients Registry Not yet recruiting NCT03788512

Search NIH Clinical Center for Cerebral Atherosclerosis

Cochrane evidence based reviews: intracranial arteriosclerosis

Genetic Tests for Cerebral Atherosclerosis

Anatomical Context for Cerebral Atherosclerosis

MalaCards organs/tissues related to Cerebral Atherosclerosis:

41
Brain, Smooth Muscle, Heart, Endothelial, Globus Pallidus

Publications for Cerebral Atherosclerosis

Articles related to Cerebral Atherosclerosis:

(show top 50) (show all 140)
# Title Authors Year
1
Ethnic Differences in Intracranial Artery Tortuosity: A Possible Reason for Different Locations of Cerebral Atherosclerosis. ( 29402073 )
2018
2
Plasma miR-126 and miR-143 as Potential Novel Biomarkers for Cerebral Atherosclerosis. ( 30309729 )
2018
3
Intracranial Arterial Calcificationes Can Reflect Cerebral Atherosclerosis Burden. ( 30375758 )
2018
4
The Impact of Cerebral Atherosclerosis According to Location on Prognosis after Coronary Artery Bypass Grafting. ( 30408800 )
2018
5
Is obstructive sleep apnea associated with the presence of intracranial cerebral atherosclerosis? ( 28168435 )
2017
6
Interarm Systolic and Diastolic Blood Pressure Difference Is Diversely Associated With Cerebral Atherosclerosis in Noncardioembolic Stroke Patients. ( 28985258 )
2017
7
Differential impact of serum total bilirubin level on cerebral atherosclerosis and cerebral small vessel disease. ( 28319156 )
2017
8
Proteomic analysis and comparison of intraa89 and extracranial cerebral atherosclerosis responses to hyperlipidemia in rabbits. ( 28677755 )
2017
9
Location of cerebral atherosclerosis: Why is there a difference between East and West? ( 27145795 )
2016
10
Value of higher-resolution MRI in assessing middle cerebral atherosclerosis and predicting capsular warning syndrome. ( 27080075 )
2016
11
Intake of antioxidants and B vitamins is inversely associated with ischemic stroke and cerebral atherosclerosis. ( 27698959 )
2016
12
Erratum: The role of shear stress and arteriogenesis in maintaining vascular homeostasis and preventing cerebral atherosclerosis. ( 30276281 )
2016
13
A pathological perspective on the natural history of cerebral atherosclerosis. ( 25854637 )
2015
14
Susceptibility vessel signs on T2*-weighted gradient echo images in patients with cerebral atherosclerosis. ( 25231582 )
2014
15
Letter by Tsuda regarding article, "Serum alkaline phosphatase and phosphate in cerebral atherosclerosis and functional outcomes after cerebral infarction". ( 24448990 )
2014
16
Response to letter regarding article, "Serum alkaline phosphatase and phosphate in cerebral atherosclerosis and functional outcomes after cerebral infarction". ( 24448989 )
2014
17
Elevated AI^42 in aged, non-demented individuals with cerebral atherosclerosis. ( 23919773 )
2013
18
Nonrelevant cerebral atherosclerosis is a strong prognostic factor in acute cerebral infarction. ( 23686972 )
2013
19
Relationship between Cerebral Atherosclerosis and Leukoaraiosis in Aged Patients: Results from DSA. ( 24033698 )
2013
20
Different impact of hyperhomocysteinemia on cerebral small vessel ischemia and cervico-cerebral atherosclerosis in non-stroke individuals. ( 23218488 )
2013
21
Serum alkaline phosphatase and phosphate in cerebral atherosclerosis and functional outcomes after cerebral infarction. ( 24021686 )
2013
22
Cerebral atherosclerosis is associated with cystic infarcts and microinfarcts but not Alzheimer pathologic changes. ( 23887837 )
2013
23
Increases in cerebral atherosclerosis according to CHADS2 scores in patients with stroke with nonvalvular atrial fibrillation. ( 21350200 )
2011
24
The association between cerebral atherosclerosis and arterial stiffness in acute ischemic stroke. ( 21974846 )
2011
25
Gender differences in risk factors for intracranial cerebral atherosclerosis among asymptomatic subjects. ( 21497768 )
2011
26
Plasma total homocysteine and the methylenetetrahydrofolate reductase 677C>T polymorphism do not contribute to the distribution of cervico-cerebral atherosclerosis in ischaemic stroke patients. ( 20825473 )
2011
27
Cerebral atherosclerosis causes neurodegenerative diseases. ( 20037498 )
2010
28
Classic risk factors for atherosclerosis are not major determinants for location of extracranial or intracranial cerebral atherosclerosis. ( 19169042 )
2009
29
Intracranial angioplasty and stenting for cerebral atherosclerosis: a position statement of the American Society of Interventional and Therapeutic Neuroradiology, Society of Interventional Radiology, and the American Society of Neuroradiology. ( 19560016 )
2009
30
Endothelial function in lacunar infarction: a comparison of lacunar infarction, cerebral atherosclerosis and control group. ( 19556769 )
2009
31
Large vessel cerebral atherosclerosis is not in direct association with neuropathological lesions of Alzheimer's disease. ( 19521084 )
2009
32
Risk factors of intracranial cerebral atherosclerosis among asymptomatics. ( 17690548 )
2007
33
Intracranial angioplasty and stenting for cerebral atherosclerosis: new treatments for stroke are needed! ( 16622698 )
2006
34
Correlation of coronary and cerebral atherosclerosis: difference between extracranial and intracranial arteries. ( 16340186 )
2006
35
Intracranial angioplasty & stenting for cerebral atherosclerosis: a position statement of the American Society of Interventional and Therapeutic Neuroradiology, Society of Interventional Radiology, and the American Society of Neuroradiology. ( 16223717 )
2005
36
Intracranial angioplasty & stenting for cerebral atherosclerosis: a position statement of the American Society of Interventional and Therapeutic Neuroradiology, Society of Interventional Radiology, and the American Society of Neuroradiology. ( 16221663 )
2005
37
[The predictors of ischemic stroke in cerebral atherosclerosis and ischemic heart disease]. ( 15997569 )
2005
38
Intracranial angioplasty and stent placement for cerebral atherosclerosis. ( 15101521 )
2004
39
Cerebral atherosclerosis and oxidative stress in Alzheimer's disease. ( 14757939 )
2003
40
Cerebral atherosclerosis and mild Alzheimer's disease. ( 12855821 )
2003
41
Cerebral atherosclerosis causes neurogenic hypertension. ( 11988586 )
2002
42
Cerebral atherosclerosis and coronary calcification. ( 12364716 )
2002
43
Cerebral atherosclerosis as predictor of stroke and mortality in representative elderly population. ( 11779914 )
2002
44
Cerebral atherosclerosis occurs spontaneously in homozygous WHHL rabbits. ( 11368997 )
2001
45
Early lesions of cerebral atherosclerosis from induced hypertension in Watanabe heritable hyperlipidemic rabbits. ( 11193506 )
2000
46
The influence of the degree of cerebral atherosclerosis on the changes in hemostatic system in patients with ischemic brain disease and atherosclerotic encephalopathy. ( 10645149 )
1999
47
Relation of plasma homocyst(e)ine to cerebral infarction and cerebral atherosclerosis. ( 9836754 )
1998
48
Cerebral atherosclerosis in Parkinsonian patients. ( 18591095 )
1998
49
Granule-laden perivascular cells observed in rabbits with experimental cerebral atherosclerosis. ( 8619506 )
1996
50
The lipoprotein profile of young adults with cerebral atherosclerosis. ( 9031424 )
1996

Variations for Cerebral Atherosclerosis

Expression for Cerebral Atherosclerosis

Search GEO for disease gene expression data for Cerebral Atherosclerosis.

GO Terms for Cerebral Atherosclerosis

Cellular components related to Cerebral Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.85 ACE APOA1 APOE RPSA TPM4
2 collagen-containing extracellular matrix GO:0062023 9.61 APOA1 APOE RPSA
3 extracellular vesicle GO:1903561 9.48 APOA1 APOE
4 high-density lipoprotein particle GO:0034364 9.4 APOA1 APOE
5 very-low-density lipoprotein particle GO:0034361 9.37 APOA1 APOE
6 endocytic vesicle lumen GO:0071682 9.32 APOA1 APOE
7 low-density lipoprotein particle GO:0034362 9.26 APOA1 APOE
8 chylomicron GO:0042627 9.16 APOA1 APOE
9 intermediate-density lipoprotein particle GO:0034363 8.96 APOA1 APOE
10 discoidal high-density lipoprotein particle GO:0034365 8.62 APOA1 APOE

Biological processes related to Cerebral Atherosclerosis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cholesterol homeostasis GO:0042632 9.6 APOA1 APOE
2 cholesterol metabolic process GO:0008203 9.59 APOA1 APOE
3 retinoid metabolic process GO:0001523 9.58 APOA1 APOE
4 cholesterol biosynthetic process GO:0006695 9.58 APOA1 APOE
5 triglyceride homeostasis GO:0070328 9.57 APOA1 APOE
6 triglyceride catabolic process GO:0019433 9.56 APOA1 APOE
7 cholesterol efflux GO:0033344 9.55 APOA1 APOE
8 lipoprotein metabolic process GO:0042157 9.54 APOA1 APOE
9 reverse cholesterol transport GO:0043691 9.52 APOA1 APOE
10 high-density lipoprotein particle remodeling GO:0034375 9.51 APOA1 APOE
11 positive regulation of lipid biosynthetic process GO:0046889 9.49 APOA1 APOE
12 high-density lipoprotein particle assembly GO:0034380 9.48 APOA1 APOE
13 phospholipid efflux GO:0033700 9.46 APOA1 APOE
14 chylomicron assembly GO:0034378 9.43 APOA1 APOE
15 high-density lipoprotein particle clearance GO:0034384 9.4 APOA1 APOE
16 positive regulation of cholesterol esterification GO:0010873 9.37 APOA1 APOE
17 very-low-density lipoprotein particle remodeling GO:0034372 9.32 APOA1 APOE
18 chylomicron remodeling GO:0034371 9.26 APOA1 APOE
19 regulation of Cdc42 protein signal transduction GO:0032489 9.16 APOA1 APOE
20 regulation of cholesterol transport GO:0032374 8.96 APOA1 APOE
21 lipoprotein biosynthetic process GO:0042158 8.62 APOA1 APOE

Molecular functions related to Cerebral Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amyloid-beta binding GO:0001540 9.37 APOA1 APOE
2 cholesterol binding GO:0015485 9.32 APOA1 APOE
3 lipid transporter activity GO:0005319 9.26 APOA1 APOE
4 cholesterol transporter activity GO:0017127 9.16 APOA1 APOE
5 lipoprotein particle binding GO:0071813 8.96 APOA1 APOE
6 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 8.62 APOA1 APOE

Sources for Cerebral Atherosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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