Cerebral Atherosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Cerebral Atherosclerosis

MalaCards integrated aliases for Cerebral Atherosclerosis:

Name: Cerebral Atherosclerosis 12 54 15 17 71 32
Intracranial Arteriosclerosis 43 71


External Ids:

Disease Ontology 12 DOID:12720
ICD9CM 34 437.0
MeSH 43 D002537
NCIt 49 C34459
SNOMED-CT 67 55382008
ICD10 32 I67.2
UMLS 71 C0007771 C0007775

Summaries for Cerebral Atherosclerosis

MalaCards based summary : Cerebral Atherosclerosis, also known as intracranial arteriosclerosis, is related to atherosclerosis susceptibility and homozygous familial hypercholesterolemia. An important gene associated with Cerebral Atherosclerosis is APOE (Apolipoprotein E), and among its related pathways/superpathways are Folate Metabolism and Statin Pathway. The drugs Aspirin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include brain, smooth muscle and endothelial.

Wikipedia : 74 Cerebral atherosclerosis is a type of atherosclerosis where build-up of plaque in the blood vessels of... more...

Related Diseases for Cerebral Atherosclerosis

Diseases related to Cerebral Atherosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 182)
# Related Disease Score Top Affiliating Genes
1 atherosclerosis susceptibility 30.5 MTHFR LPA CRP APOE APOA1 ACE
2 homozygous familial hypercholesterolemia 30.1 APOE APOA1
3 arteriolosclerosis 30.0 SERPINA3 APOE
4 hyperlipoproteinemia, type iii 29.9 LPA APOE APOA1
5 sleep apnea 29.7 CRP APOE ACE
6 hypercholesterolemia, familial, 1 29.7 LPA CRP APOE APOA1 ACE
7 arteriosclerosis 29.6 LPA CRP APOE APOA1 ACE
8 vascular disease 29.5 MTHFR LPA CRP APOE APOA1 ACE
9 migraine with or without aura 1 29.5 MTHFR CRP APOE ACE
10 moyamoya disease 1 29.4 RNF213 MTHFR LPA
11 homocysteinemia 29.3 MTHFR LPA CRP APOE
12 angina pectoris 29.3 LPA CRP APOA1 ACE
13 lipoprotein quantitative trait locus 29.2 LPA CRP APOA1 ACE
14 cerebrovascular disease 29.1 SERPINA3 MTHFR LPA CRP APOE APOA1
15 carotid stenosis 29.1 MTHFR LPA CRP APOE ACE
16 carotid artery disease 29.0 LPA CRP APOE APOA1 ACE
17 familial hypercholesterolemia 29.0 LPA CRP APOE APOA1 ACE
18 peripheral vascular disease 29.0 MTHFR LPA CRP APOA1 ACE
19 vascular dementia 29.0 SERPINA3 MTHFR CRP APOE APOA1 ACE
20 stroke, ischemic 28.9 SERPINA3 MTHFR LPA CRP APOE ACE
21 coronary heart disease 1 28.8 MTHFR LPA CRP APOE APOA1 ACE
22 heart disease 28.8 MTHFR LPA CRP APOE APOA1 ACE
23 arteries, anomalies of 28.7 SERPINA3 LPA CRP APOE APOA1 ACE
24 diabetes mellitus 28.3 REG1A MTHFR LPA CRP APOE APOA1
25 intracranial arteriosclerosis 12.6
26 moderate and severe traumatic brain injury 10.5 APOE ACE
27 familial lcat deficiency 10.5 APOE APOA1
28 arteritic anterior ischemic optic neuropathy 10.5 MTHFR ACE
29 hepatic lipase deficiency 10.5 APOE APOA1
30 familial lipoprotein lipase deficiency 10.4 APOE APOA1
31 c1 inhibitor deficiency 10.3 SERPINA3 ACE
32 pediatric testicular germ cell tumor 10.3 LPA APOA1
33 livedoid vasculitis 10.3 MTHFR LPA
34 lipoprotein glomerulopathy 10.3 LPA APOE
35 alzheimer disease 2 10.3 SERPINA3 APOE
36 tropical calcific pancreatitis 10.3 REG1A ACE
37 mediastinum teratoma 10.3 CRP ACE
38 exfoliation syndrome 10.3 SERPINA3 MTHFR APOE
39 acute dacryoadenitis 10.3 CRP ACE
40 cardiac tuberculosis 10.3 CRP ACE
41 normal pressure hydrocephalus 10.3 SERPINA3 APOE ACE
42 arcus corneae 10.3 LPA APOA1
43 posterior scleritis 10.3 CRP ACE
44 tolosa-hunt syndrome 10.3 CRP ACE
45 lemierre's syndrome 10.3 MTHFR CRP
46 pancreas sarcoma 10.3 SERPINA3 LPA
47 multiple cranial nerve palsy 10.3 CRP ACE
48 cranial nerve palsy 10.3 CRP ACE
49 granulomatous angiitis 10.3 CRP ACE
50 intracranial sinus thrombosis 10.3 MTHFR CRP

Comorbidity relations with Cerebral Atherosclerosis via Phenotypic Disease Network (PDN): (show all 39)

Active Peptic Ulcer Disease Acute Cystitis
Alzheimer Disease Aortic Valve Disease 1
Basilar Artery Insufficiency Benign Essential Hypertension
Borderline Personality Disorder Bronchitis
Bronchopneumonia Cerebral Degeneration
Cerebrovascular Disease Decubitus Ulcer
Deficiency Anemia Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hypertensive Encephalopathy
Hypoglycemia Hypothyroidism
Intracranial Embolism Intracranial Thrombosis
Iron Deficiency Anemia Major Depressive Disorder
Malignant Essential Hypertension Osteoporosis
Parkinson Disease, Late-Onset Peripheral Vascular Disease
Protein-Energy Malnutrition Pseudobulbar Palsy
Schizophreniform Disorder Sinoatrial Node Disease
Status Epilepticus Swallowing Disorders
Transient Cerebral Ischemia Vascular Dementia
Vertebral Artery Insufficiency

Graphical network of the top 20 diseases related to Cerebral Atherosclerosis:

Diseases related to Cerebral Atherosclerosis

Symptoms & Phenotypes for Cerebral Atherosclerosis

Drugs & Therapeutics for Cerebral Atherosclerosis

Drugs for Cerebral Atherosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 99)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
Lisinopril Approved, Investigational Phase 4 76547-98-3, 83915-83-7 5362119
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
Propranolol Approved, Investigational Phase 4 525-66-6 4946
Atenolol Approved Phase 4 29122-68-7 2249
Amlodipine Approved Phase 4 88150-42-9 2162
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
Atorvastatin Approved Phase 4 134523-00-5 60823
tannic acid Approved Phase 4 1401-55-4
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
Probucol Approved, Investigational Phase 4 23288-49-5 4912
15 Platelet Aggregation Inhibitors Phase 4
16 Analgesics, Non-Narcotic Phase 4
17 Fibrinolytic Agents Phase 4
18 Purinergic P2Y Receptor Antagonists Phase 4
19 Analgesics Phase 4
20 Antipyretics Phase 4
21 Cyclooxygenase Inhibitors Phase 4
22 Neurotransmitter Agents Phase 4
23 Anti-Inflammatory Agents Phase 4
24 Anti-Inflammatory Agents, Non-Steroidal Phase 4
25 Antirheumatic Agents Phase 4
26 Protective Agents Phase 4
27 Respiratory System Agents Phase 4
28 Phosphodiesterase 3 Inhibitors Phase 4
29 Anti-Asthmatic Agents Phase 4
30 Phosphodiesterase Inhibitors Phase 4
31 Vasodilator Agents Phase 4
32 Neuroprotective Agents Phase 4
33 Bronchodilator Agents Phase 4
protease inhibitors Phase 4
35 HIV Protease Inhibitors Phase 4
36 Adrenergic beta-Antagonists Phase 4
37 Adrenergic beta-1 Receptor Antagonists Phase 4
38 Cardiotonic Agents Phase 4
39 Angiotensin-Converting Enzyme Inhibitors Phase 4
40 Adrenergic Agents Phase 4
41 Adrenergic Antagonists Phase 4
42 Anti-Arrhythmia Agents Phase 4
43 Sympatholytics Phase 4
44 Telmisartan amlodipine combination Phase 4
45 calcium channel blockers Phase 4
46 Hypolipidemic Agents Phase 4
47 Lipid Regulating Agents Phase 4
48 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
49 Anticholesteremic Agents Phase 4
50 Calcium, Dietary Phase 4

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 Intensive Statin Treatment in Acute Ischemic Stroke Patients With INtracranial Atherosclerosis - High-Resolution Magnetic Resonance Imaging Study (STAMINA-MRI Study) Unknown status NCT02458755 Phase 4 High-dose statin: Atorvastatin 40mg or Rosuvastatin 20mg
2 Multicenter Double-blind Placebo-controlled Parallel-group Randomized Clinical Trial of Efficacy and Safety of Divaza in the Management of Oxidative Disturbances in Cerebral Atherosclerosis Completed NCT03485495 Phase 4 Divaza;Placebo
3 A Randomized, Control, Open Label, Multicentre Clinical Study to Evaluate the Efficacy and Safety of Cilostazol and Probucol Alone and in Combination on Atherosclerosis Related Biomarker---atherosclerosis Cerebral Infarction Patient as Study Subject Completed NCT00823875 Phase 4 Cilostazol group;Probucol group;Cilostazol + Probucol group;control group
4 Reducing Total Cardiovascular Risk in an Urban Community Completed NCT00241904 Phase 4 Antiplatelet Agents;Beta Blocker;ACE Inhibitors
5 Hypertension With Obesity Trial: Diabetes Mellitus Branch Completed NCT00847262 Phase 4 Temisartan;Amlodipine
6 The Effects of Physical Training, Aspirin, and Clopidogrel on the Walking Capacity of Patients With Stage II Peripheral Arterial Disease Completed NCT00189618 Phase 4 Aspirin;Clopidogrel
7 The Effect of InTensive Statin in Ischemic Stroke With inTracranial Atherosclerotic Plaques: a Prospective, Random, Single-center Study Based on High Resolution Magnetic Resonance Imaging Recruiting NCT03753555 Phase 4 Atorvastatin Calcium;Atorvastatin Calcium;Probucol
8 Multicenter Clinical Trial for Development of Guidelines of Adequate Blood Pressure Lowering in the Subacute Ischemic Stroke Patients Due to Intracranial Atherosclerosis Terminated NCT01104311 Phase 4
9 Study of Urinary Kallikrein to Enhance Collateral Circulation in Symptomatic Intracranial Atherosclerosis: a Study Based on Whole-brain CTP Withdrawn NCT04325932 Phase 4 Urinary Kallikrein
10 Angioplasty and Stenting for Patients With Symptomatic Intracranial Atherosclerosis: Study Protocol of a Randomized Controlled Trial Unknown status NCT02689037 Phase 3 Aspirin plus clopidogrel
11 The Impact of Repeated Bilateral Limb Remote Ischemic Conditioning on Patients With Chronic Cerebral Ischemia: Establishment of Optimized Algorithm on the Basis of Feasibility, Safety and Efficacy Unknown status NCT03105141 Phase 2, Phase 3
12 Cilostazol-Aspirin Therapy Against Recurrent Stroke With Intracranial Artery Stenosis (CATHARSIS) Completed NCT00333164 Phase 3 Asprin, Cilostazol
13 Cholesterol-Lowering Atherosclerosis Study (CLAS) Completed NCT00000599 Phase 3 colestipol;niacin
14 Prevention for the Restenosis of Intracranial Artery Stent Implantation Treated With Herbal Medicine C117--PRISIT Trial Unknown status NCT03008798 Phase 2 Herbal Medicine C-117;The Placebo of Herbal Medicine C-117
15 Asymptomatic Carotid Artery Plaque Study (ACAPS) Completed NCT00000469 Phase 2 aspirin;lovastatin
16 Antioxidants and Prevention of Early Atherosclerosis Terminated NCT00000600 Phase 2 Vitamin E;Vitamin C
17 A Single/Multiple Ascending Dose Phase 1 Study of the Safety, Tolerability and Pharmacologic Activity of BT200 in Normal Human Volunteers Recruiting NCT04103034 Phase 1 BT200;Desmopressin;Placebo
18 Treatment Targets for Inflamed Intracranial Atherosclerosis on Vessel Wall MRI Enrolling by invitation NCT03084523 Phase 1 Ferumoxytol Injectable Product
19 Wingspan Stenting for Symptomatic Severe Stenosis of Intracranial Atherosclerosis Registry in China Unknown status NCT00685308
20 Clinical Trail of Hybrid Operating Technique in Management of Intracranial Aneurysms With Coexistence of Atherosclerotic Intracranial Arterial Stenosis Unknown status NCT03204435
21 Remote Ischemic Conditioning for Avoiding Recurrence of Ischemic Stroke in Patients With Symptomatic Intracranial Atherosclerotic Stenosis Unknown status NCT02534545
22 Vessel Wall and Perfusion Imaging in Intracranial Atherosclerosis Unknown status NCT02719652
23 An Open-label, Single-centre Study Evaluating the Prevalence and Characteristics of Coronary and Cerebrovascular Arteriosclerosis as Measured by Combined Coronary and Cerebral Angiography, and Comparing the Efficacy and Safety of Simultaneous or Staged Coronary and Cerebral Interventional Strategy in Chinese Patients Unknown status NCT02315924
24 Intracranial Atherosclerosis and Predictors of Post-CABG Depression Completed NCT01838356
25 Stroke Imaging Package Study Completed NCT02485275
26 WEAVE™ Trial: Wingspan StEnt System Post MArket SurVEillance Study Completed NCT02034058
27 An International Registry of the Wingspan™ Stent System for the Treatment of Intracranial Atherosclerotic Stenosis Completed NCT00929383
28 Epidemiology of Vascular Inflammation & Atherosclerosis Completed NCT00087893
29 Pilot Study of Pre-Ischemic Conditioning for Intracranial Atherosclerosis Completed NCT03208166
30 Identification of the Antiplatelet Compounds of Garlic Ex Vivo Completed NCT00200785
31 Boston Scientific EPI: A Carotid Stenting Trial for High-Risk Surgical Patients Completed NCT00316108
32 Asymptomatic Intracranial Atherosclerotic Disease: Prevalence, Clinical and Lifestyle Determinants in Urban Pakistan Completed NCT02072876
33 Gene-by-Smoking Interactions and Risk of Atherosclerosis - Ancillary to ARIC Completed NCT00064545
34 EDAS (Surgical) Revascularization for Symptomatic Intracranial Arterial Stenosis Completed NCT01819597
35 Morphology of Advanced Symptomatic Cerebral Plaques With High Embolic Potential Recruiting NCT03291652
36 Morphologic Evolution and Remodeling of Intracranial Atherosclerosis: A Longitudinal Study by 3D-rotational Angiography Recruiting NCT03295773
37 Vessel Wall MR Imaging to Explore Sex-Differences of Intracranial Arterial Wall Changes After Suspected Stroke Recruiting NCT03990545
38 Stroke Imaging Package Study of Intracranial Atherosclerosis Recruiting NCT03719820 aggressive medical management
39 The Role of Additional Antiplatelet Therapy in the Ischemic Stroke With Atrial Fibrillation and Co-morbiD Atherosclerosis During edOxaban treatmeNt. (ADD-ON) Study, Multicenter Registry-based Analysis Recruiting NCT04010955 Edoxaban Monotherapy
40 CUHK Stroke Biobank Recruiting NCT03291392
41 Coexistence of Cerebral and Coronary Atherosclerosis in Acute Ischemic Cerebrovascular Disease Patients Registry Recruiting NCT03788512
42 PCSK9 Inhibition in Patients With Symptomatic Intracranial Atherosclerosis Terminated NCT03507374 Early Phase 1 Alirocumab;Placebo

Search NIH Clinical Center for Cerebral Atherosclerosis

Cochrane evidence based reviews: intracranial arteriosclerosis

Genetic Tests for Cerebral Atherosclerosis

Anatomical Context for Cerebral Atherosclerosis

MalaCards organs/tissues related to Cerebral Atherosclerosis:

Brain, Smooth Muscle, Endothelial, Heart, Cortex, Testes, Adrenal Cortex

Publications for Cerebral Atherosclerosis

Articles related to Cerebral Atherosclerosis:

(show top 50) (show all 549)
# Title Authors PMID Year
[Sensitivity of atherosclerosis indices in patients with ischemic brain disease]. 61 54
8560842 1994
Role of activin receptor-like kinase 1 in vascular development and cerebrovascular diseases. 61
32246621 2020
Are Genetic Variants Associated with the Location of Cerebral Arterial Lesions in Stroke Patients? 61
32526736 2020
Publisher Correction: Shared proteomic effects of cerebral atherosclerosis and Alzheimer's disease on the human brain. 61
32576978 2020
Shared proteomic effects of cerebral atherosclerosis and Alzheimer's disease on the human brain. 61
32424284 2020
Comparison of Prediction Models based on Risk Factors and Retinal Characteristics Associated with Recurrence One Year after Ischemic Stroke. 61
31928865 2020
Association between Plasma Adipocytokines Levels and Intracranial versus Extracranial Atherosclerotic among Chinese Patients with Stroke. 61
32548044 2020
32383700 2020
Distribution of cerebral artery stenosis and risk factors in ethnic Zhuang and Han patients with ischemic stroke in Guangxi province. 61
32156133 2020
Plasma RANTES level is correlated with cardio-cerebral atherosclerosis burden in patients with ischemic cerebrovascular disease. 61
32226934 2020
Plasma Fibroblast Growth Factor 23 Concentration Is Associated with Intracranial Cerebral Atherosclerosis in Acute Ischemic Stroke Patients. 61
31942755 2020
[Incidence of postoperative cognitive dysfunction after simultaneous carotid surgery and coronary artery bypass grafting in patients with asymptomatic cerebral atherosclerosis]. 61
32307423 2020
Coronary Calcium Score for the Prediction of Asymptomatic Coronary Artery Disease in Patients With Ischemic Stroke. 61
32292387 2020
A cross-sectional feasibility study of neurovascular ultrasound in Malawian adults with acute stroke-like syndrome. 61
32032392 2020
[Expanding the possibilities of antithrombotic therapy of cerebrovascular pathology]. 61
32490629 2020
Late-Onset Wilson's Disease. 61
32118011 2020
Circular RNA circ_0003204 inhibits proliferation, migration and tube formation of endothelial cell in atherosclerosis via miR-370-3p/TGFβR2/phosph-SMAD3 axis. 61
31900142 2020
Cognitive disorders in persons of working age with dyscirculatory encephalopathy. 61
32285811 2020
Effects of lncRNA gm4419 on rats with hypertensive cerebral atherosclerosis through NF-κB pathway. 61
31858567 2019
Correlation between Metabolic Syndrome and Intracranial versus Extracranial Arteriosclerosis among Chinese Patients with Stroke. 61
31970098 2019
Subclinical Peripheral Arterial Disease in Patients with Acute Ischemic Stroke: A Study with Ultrasonography. 61
31522885 2019
A Comprehensive Assessment of Vascular and Nonvascular Risk Factors Associated with Migraine. 61
31890393 2019
[Association between soluble receptor for advanced glycation end products (sRAGE) and coronary and cerebral atherosclerosis]. 61
31648447 2019
Serum Aldosterone Is Associated with Cerebral Artery Atherosclerosis and Calcification. 61
30528672 2019
Cigarette Smoking Preferentially Affects Intracranial Vessels in Young Males: A Propensity-Score Matching Analysis. 61
30827064 2019
[Applications of cerebral bypass surgery in modern neurosurgery]. 61
30931883 2019
Characteristics and Factors for Short-Term Functional Outcome in Stroke Patients With Atrial Fibrillation, Nationwide Retrospective Cohort Study. 61
31681159 2019
Antiphospholipid Antibodies: Cognitive and Motor Decline, Neuroimaging and Neuropathology. 61
31067547 2019
Successful Endovascular Bailout Strategy for Retained Accunet Embolic Protection Device During Vertebral Artery Stenting. 61
30915017 2019
A Simple Scoring Model for Prediction of Rupture Risk of Anterior Communicating Artery Aneurysms. 61
31214103 2019
Intracranial Arterial Calcificationes Can Reflect Cerebral Atherosclerosis Burden. 61
30375758 2019
Plasma miR-126 and miR-143 as Potential Novel Biomarkers for Cerebral Atherosclerosis. 61
30309729 2019
Width of sulcus and thickness of gyrus in patients with cerebral atherosclerosis: a new tool for the prevention of vascular cognitive impairment. 61
30673038 2018
Computed Tomography Angiography Evaluation of Risk Factors for Unstable Intracranial Aneurysms. 61
29567291 2018
Increase in perfused boundary region of endothelial glycocalyx is associated with higher prevalence of ischemic heart disease and lesions of microcirculation and vascular wall. 61
29608790 2018
Cerebrovascular Reactivity and Carotid Intima-Media Thickness in Opium Dependents: A Case-Control Study. 61
31069037 2018
Risk Factors for the Rupture of Intracranial Aneurysms Using Computed Tomography Angiography. 61
29129762 2018
Association Between Net Vertebral Artery Flow Volume and Non-AF Stroke: A Retrospective 2-Year Analysis. 61
30713522 2018
Role of Noninvasive Imaging of Cerebral Arterial System in Ischemic Stroke: Comparison of Transcranial Color-coded Doppler Sonography with Magnetic Resonance Angiography. 61
29770267 2018
The Prevalence and Distribution of Occlusive Lesions of the Cerebral Arteries in Patients Undergoing Coronary Artery Bypass Graft Surgery. 61
29518536 2018
Association of Homocysteine with Aysmptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients. 61
29330520 2018
[Clinical features of ischaemic stroke with cerebral venous insufficiency and its risk factors.] 61
30080335 2018
Risk factors for ruptured intracranial aneurysms. 61
29749361 2018
[Cerebral atherosclerosis: a biomarker profile]. 61
29927399 2018
Ethnic Differences in Intracranial Artery Tortuosity: A Possible Reason for Different Locations of Cerebral Atherosclerosis. 61
29402073 2018
[Experimental evaluation of the therapeutic potential of liposome-mediated apoe3 gene transfection for cerebral atherosclerosis]. 61
29783206 2018
The Impact of Cerebral Atherosclerosis According to Location on Prognosis after Coronary Artery Bypass Grafting. 61
30408800 2018
Location of cerebral atherosclerosis: Why is there a difference between East and West? 61
27145795 2018
Interarm Systolic and Diastolic Blood Pressure Difference Is Diversely Associated With Cerebral Atherosclerosis in Noncardioembolic Stroke Patients. 61
28985258 2017
Is obstructive sleep apnea associated with the presence of intracranial cerebral atherosclerosis? 61
28168435 2017

Variations for Cerebral Atherosclerosis

Expression for Cerebral Atherosclerosis

Search GEO for disease gene expression data for Cerebral Atherosclerosis.

Pathways for Cerebral Atherosclerosis

Pathways related to Cerebral Atherosclerosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways

GO Terms for Cerebral Atherosclerosis

Cellular components related to Cerebral Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.61 SERPINA3 APOE APOA1
2 extracellular space GO:0005615 9.56 SERPINA3 REG1A MIR660 MIR1306 CRP APOE
3 very-low-density lipoprotein particle GO:0034361 9.4 APOE APOA1
4 endocytic vesicle lumen GO:0071682 9.37 APOE APOA1
5 low-density lipoprotein particle GO:0034362 9.32 APOE APOA1
6 chylomicron GO:0042627 9.26 APOE APOA1
7 intermediate-density lipoprotein particle GO:0034363 9.16 APOE APOA1
8 discoidal high-density lipoprotein particle GO:0034365 8.62 APOE APOA1

Biological processes related to Cerebral Atherosclerosis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 lipid transport GO:0006869 9.73 LPA APOE APOA1
2 cholesterol efflux GO:0033344 9.57 APOE APOA1
3 positive regulation of cholesterol efflux GO:0010875 9.55 APOE APOA1
4 reverse cholesterol transport GO:0043691 9.54 APOE APOA1
5 high-density lipoprotein particle remodeling GO:0034375 9.52 APOE APOA1
6 positive regulation of lipid biosynthetic process GO:0046889 9.51 APOE APOA1
7 low-density lipoprotein particle remodeling GO:0034374 9.49 LPA APOE
8 high-density lipoprotein particle assembly GO:0034380 9.48 APOE APOA1
9 phospholipid efflux GO:0033700 9.46 APOE APOA1
10 high-density lipoprotein particle clearance GO:0034384 9.43 APOE APOA1
11 chylomicron assembly GO:0034378 9.4 APOE APOA1
12 very-low-density lipoprotein particle remodeling GO:0034372 9.37 APOE APOA1
13 chylomicron remodeling GO:0034371 9.32 APOE APOA1
14 positive regulation of cholesterol esterification GO:0010873 9.26 APOE APOA1
15 regulation of Cdc42 protein signal transduction GO:0032489 9.16 APOE APOA1
16 lipoprotein biosynthetic process GO:0042158 8.96 APOE APOA1
17 positive regulation of phospholipid efflux GO:1902995 8.62 APOE APOA1

Molecular functions related to Cerebral Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 low-density lipoprotein particle receptor binding GO:0050750 9.26 CRP APOE
2 intermembrane cholesterol transfer activity GO:0120020 9.16 APOE APOA1
3 lipoprotein particle binding GO:0071813 8.96 APOE APOA1
4 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 8.62 APOE APOA1

Sources for Cerebral Atherosclerosis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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