MCID: CRB008
MIFTS: 41

Cerebral Atherosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Cerebral Atherosclerosis

MalaCards integrated aliases for Cerebral Atherosclerosis:

Name: Cerebral Atherosclerosis 12 55 15 73
Intracranial Arteriosclerosis 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12720
ICD10 33 I67.2
ICD9CM 35 437.0
MeSH 44 D002537
NCIt 50 C34459
UMLS 73 C0007775

Summaries for Cerebral Atherosclerosis

MalaCards based summary : Cerebral Atherosclerosis, also known as intracranial arteriosclerosis, is related to stroke, ischemic and sleep apnea. An important gene associated with Cerebral Atherosclerosis is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Folate Metabolism. The drugs Cilostazol and Probucol have been mentioned in the context of this disorder. Affiliated tissues include brain, smooth muscle and heart, and related phenotypes are Increased LDL uptake and cardiovascular system

Wikipedia : 76 Cerebral atherosclerosis is a type of atherosclerosis where build-up of plaque in the blood vessels of... more...

Related Diseases for Cerebral Atherosclerosis

Diseases related to Cerebral Atherosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 stroke, ischemic 29.7 ACE APOE MTHFR
2 sleep apnea 29.4 ACE APOE
3 ischemic heart disease 29.1 ACE APOA1 APOE
4 coronary heart disease 1 29.1 ACE APOA1 APOE
5 heart disease 28.6 ACE APOA1 APOE MTHFR
6 cerebrovascular disease 28.5 ACE APOA1 APOE MTHFR
7 vascular disease 28.4 ACE APOA1 APOE MTHFR
8 intracranial arteriosclerosis 12.2
9 cerebritis 10.7
10 moderate and severe traumatic brain injury 10.4 ACE APOE
11 generalized atherosclerosis 10.4 ACE APOE
12 arteritic anterior ischemic optic neuropathy 10.4 ACE MTHFR
13 aortic atherosclerosis 10.4 ACE APOE
14 nephrosclerosis 10.3 ACE MTHFR
15 hemorrhage, intracerebral 10.3 ACE APOE
16 familial lcat deficiency 10.3 APOA1 APOE
17 exfoliation syndrome 10.3 APOE MTHFR
18 ischemic optic neuropathy 10.3 ACE MTHFR
19 hepatic lipase deficiency 10.3 APOA1 APOE
20 leukodystrophy, hypomyelinating, 3 10.3 APOA1 APOE
21 hyperlipidemia, familial combined 10.3 APOA1 APOE
22 hypobetalipoproteinemia, familial, 1 10.3 APOA1 APOE
23 hyperlipoproteinemia, type iv 10.3 APOA1 APOE
24 nonarteritic anterior ischemic optic neuropathy 10.3 ACE MTHFR
25 hypolipoproteinemia 10.3 APOA1 APOE
26 hyperlipoproteinemia, type iii 10.2 APOA1 APOE
27 arcus corneae 10.2 APOA1 APOE
28 hyperalphalipoproteinemia 1 10.2 APOA1 APOE
29 abetalipoproteinemia 10.2 APOA1 APOE
30 aging 10.2
31 lecithin:cholesterol acyltransferase deficiency 10.1 APOA1 APOE
32 familial hyperlipidemia 10.1 APOA1 APOE
33 gallbladder disease 10.1 APOA1 APOE
34 migraine with aura 10.1 ACE MTHFR
35 tangier disease 10.1 APOA1 APOE
36 inherited metabolic disorder 10.1 APOA1 MTHFR
37 cerebral palsy 10.0 APOE MTHFR
38 carotid stenosis 10.0 ACE APOE MTHFR
39 vascular dementia 10.0 ACE APOE MTHFR
40 fibromuscular dysplasia 9.9 ACE RNF213
41 alzheimer disease 9.8
42 coronary stenosis 9.8 ACE APOA1 APOE
43 carotid artery disease 9.8 ACE APOA1 APOE
44 lipid metabolism disorder 9.8 ACE APOA1 APOE
45 arteriosclerosis 9.8 ACE APOA1 APOE
46 peripheral vascular disease 9.7 ACE APOA1
47 cerebral arterial disease 9.7 RNF213 RPSA
48 moyamoya disease 1 9.6 RNF213 RPSA
49 apnea, obstructive sleep 9.6
50 hypercholesterolemia, familial 9.6

Comorbidity relations with Cerebral Atherosclerosis via Phenotypic Disease Network (PDN): (show all 42)


Active Peptic Ulcer Disease Acute Cystitis
Alzheimer Disease Aortic Valve Disease 1
Basilar Artery Insufficiency Benign Essential Hypertension
Borderline Personality Disorder Bronchitis
Bronchopneumonia Cerebral Degeneration
Cerebrovascular Disease Chronic Kidney Failure
Chronic Myocardial Ischemia Decubitus Ulcer
Deficiency Anemia Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hypertensive Encephalopathy
Hypoglycemia Hypothyroidism
Intracranial Embolism Intracranial Thrombosis
Iron Deficiency Anemia Ischemic Heart Disease
Major Depressive Disorder Malignant Essential Hypertension
Osteoporosis Parkinson Disease, Late-Onset
Peripheral Vascular Disease Protein-Energy Malnutrition
Pseudobulbar Palsy Schizophreniform Disorder
Sinoatrial Node Disease Status Epilepticus
Swallowing Disorders Transient Cerebral Ischemia
Vascular Dementia Vertebral Artery Insufficiency

Graphical network of the top 20 diseases related to Cerebral Atherosclerosis:



Diseases related to Cerebral Atherosclerosis

Symptoms & Phenotypes for Cerebral Atherosclerosis

GenomeRNAi Phenotypes related to Cerebral Atherosclerosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased LDL uptake GR00340-A-1 8.62 APOA1 APOE

MGI Mouse Phenotypes related to Cerebral Atherosclerosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.35 APOE RNF213 RPSA ACE APOA1
2 endocrine/exocrine gland MP:0005379 9.02 RNF213 RPSA ACE APOA1 APOE

Drugs & Therapeutics for Cerebral Atherosclerosis

Drugs for Cerebral Atherosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
2
Probucol Approved, Investigational Phase 4 23288-49-5 4912
3
Amlodipine Approved Phase 4 88150-42-9 2162
4
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
5
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
6 Anti-Asthmatic Agents Phase 4
7 Anticholesteremic Agents Phase 4
8 Antimetabolites Phase 4
9 Antioxidants Phase 4
10 Autonomic Agents Phase 4
11 Bronchodilator Agents Phase 4
12 Fibrinolytic Agents Phase 4
13 Hypolipidemic Agents Phase 4
14 Lipid Regulating Agents Phase 4
15 Neuroprotective Agents Phase 4
16 Peripheral Nervous System Agents Phase 4
17 Phosphodiesterase 3 Inhibitors Phase 4
18 Phosphodiesterase Inhibitors Phase 4
19 Platelet Aggregation Inhibitors Phase 4
20 Protective Agents Phase 4
21 Respiratory System Agents Phase 4
22 Vasodilator Agents Phase 4
23 Angiotensin II Type 1 Receptor Blockers Phase 4
24 Angiotensin Receptor Antagonists Phase 4
25 Angiotensinogen Phase 4
26 Antihypertensive Agents Phase 4
27 calcium channel blockers Phase 4
28 Calcium, Dietary Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Cilostazol and Probucol Alone and in Combination on Atherosclerosis Related Biomarker---atherosclerosis Cerebral Infarction Patient as Study Subject Completed NCT00823875 Phase 4 Cilostazol group;Probucol group;Cilostazol + Probucol group;control group
2 Trial Comparing Metabolic Effects of Telmisartan and Amlodipine on Hypertensive Patients With Obesity and Diabetes Completed NCT00847262 Phase 4 Temisartan;Amlodipine
3 Clinical Trial of Efficacy and Safety of Divaza in the Management of Oxidative Disturbances in Cerebral Atherosclerosis Recruiting NCT03485495 Phase 4 Divaza;Placebo
4 Combined Coronary and Cerebral Angiography and Intervention for Coronary and Cerebrovascular Atherosclerosis Unknown status NCT02315924 Not Applicable

Search NIH Clinical Center for Cerebral Atherosclerosis

Cochrane evidence based reviews: intracranial arteriosclerosis

Genetic Tests for Cerebral Atherosclerosis

Anatomical Context for Cerebral Atherosclerosis

MalaCards organs/tissues related to Cerebral Atherosclerosis:

41
Brain, Smooth Muscle, Heart, Globus Pallidus, Endothelial

Publications for Cerebral Atherosclerosis

Articles related to Cerebral Atherosclerosis:

(show top 50) (show all 136)
# Title Authors Year
1
Ethnic Differences in Intracranial Artery Tortuosity: A Possible Reason for Different Locations of Cerebral Atherosclerosis. ( 29402073 )
2018
2
Is obstructive sleep apnea associated with the presence of intracranial cerebral atherosclerosis? ( 28168435 )
2017
3
Interarm Systolic and Diastolic Blood Pressure Difference Is Diversely Associated With Cerebral Atherosclerosis in Noncardioembolic Stroke Patients. ( 28985258 )
2017
4
Differential impact of serum total bilirubin level on cerebral atherosclerosis and cerebral small vessel disease. ( 28319156 )
2017
5
Proteomic analysis and comparison of intraa89 and extracranial cerebral atherosclerosis responses to hyperlipidemia in rabbits. ( 28677755 )
2017
6
Location of cerebral atherosclerosis: Why is there a difference between East and West? ( 27145795 )
2016
7
Value of higher-resolution MRI in assessing middle cerebral atherosclerosis and predicting capsular warning syndrome. ( 27080075 )
2016
8
Intake of antioxidants and B vitamins is inversely associated with ischemic stroke and cerebral atherosclerosis. ( 27698959 )
2016
9
A pathological perspective on the natural history of cerebral atherosclerosis. ( 25854637 )
2015
10
Susceptibility vessel signs on T2*-weighted gradient echo images in patients with cerebral atherosclerosis. ( 25231582 )
2014
11
Letter by Tsuda regarding article, "Serum alkaline phosphatase and phosphate in cerebral atherosclerosis and functional outcomes after cerebral infarction". ( 24448990 )
2014
12
Response to letter regarding article, "Serum alkaline phosphatase and phosphate in cerebral atherosclerosis and functional outcomes after cerebral infarction". ( 24448989 )
2014
13
Elevated AI^42 in aged, non-demented individuals with cerebral atherosclerosis. ( 23919773 )
2013
14
Nonrelevant cerebral atherosclerosis is a strong prognostic factor in acute cerebral infarction. ( 23686972 )
2013
15
Relationship between Cerebral Atherosclerosis and Leukoaraiosis in Aged Patients: Results from DSA. ( 24033698 )
2013
16
Different impact of hyperhomocysteinemia on cerebral small vessel ischemia and cervico-cerebral atherosclerosis in non-stroke individuals. ( 23218488 )
2013
17
Serum alkaline phosphatase and phosphate in cerebral atherosclerosis and functional outcomes after cerebral infarction. ( 24021686 )
2013
18
Cerebral atherosclerosis is associated with cystic infarcts and microinfarcts but not Alzheimer pathologic changes. ( 23887837 )
2013
19
Increases in cerebral atherosclerosis according to CHADS2 scores in patients with stroke with nonvalvular atrial fibrillation. ( 21350200 )
2011
20
The association between cerebral atherosclerosis and arterial stiffness in acute ischemic stroke. ( 21974846 )
2011
21
Gender differences in risk factors for intracranial cerebral atherosclerosis among asymptomatic subjects. ( 21497768 )
2011
22
Plasma total homocysteine and the methylenetetrahydrofolate reductase 677C>T polymorphism do not contribute to the distribution of cervico-cerebral atherosclerosis in ischaemic stroke patients. ( 20825473 )
2011
23
Cerebral atherosclerosis causes neurodegenerative diseases. ( 20037498 )
2010
24
Classic risk factors for atherosclerosis are not major determinants for location of extracranial or intracranial cerebral atherosclerosis. ( 19169042 )
2009
25
Intracranial angioplasty and stenting for cerebral atherosclerosis: a position statement of the American Society of Interventional and Therapeutic Neuroradiology, Society of Interventional Radiology, and the American Society of Neuroradiology. ( 19560016 )
2009
26
Endothelial function in lacunar infarction: a comparison of lacunar infarction, cerebral atherosclerosis and control group. ( 19556769 )
2009
27
Large vessel cerebral atherosclerosis is not in direct association with neuropathological lesions of Alzheimer's disease. ( 19521084 )
2009
28
Risk factors of intracranial cerebral atherosclerosis among asymptomatics. ( 17690548 )
2007
29
Intracranial angioplasty and stenting for cerebral atherosclerosis: new treatments for stroke are needed! ( 16622698 )
2006
30
Correlation of coronary and cerebral atherosclerosis: difference between extracranial and intracranial arteries. ( 16340186 )
2006
31
Intracranial angioplasty & stenting for cerebral atherosclerosis: a position statement of the American Society of Interventional and Therapeutic Neuroradiology, Society of Interventional Radiology, and the American Society of Neuroradiology. ( 16223717 )
2005
32
Intracranial angioplasty & stenting for cerebral atherosclerosis: a position statement of the American Society of Interventional and Therapeutic Neuroradiology, Society of Interventional Radiology, and the American Society of Neuroradiology. ( 16221663 )
2005
33
[The predictors of ischemic stroke in cerebral atherosclerosis and ischemic heart disease]. ( 15997569 )
2005
34
Intracranial angioplasty and stent placement for cerebral atherosclerosis. ( 15101521 )
2004
35
Cerebral atherosclerosis and oxidative stress in Alzheimer's disease. ( 14757939 )
2003
36
Cerebral atherosclerosis and mild Alzheimer's disease. ( 12855821 )
2003
37
Cerebral atherosclerosis causes neurogenic hypertension. ( 11988586 )
2002
38
Cerebral atherosclerosis and coronary calcification. ( 12364716 )
2002
39
Cerebral atherosclerosis as predictor of stroke and mortality in representative elderly population. ( 11779914 )
2002
40
Cerebral atherosclerosis occurs spontaneously in homozygous WHHL rabbits. ( 11368997 )
2001
41
Early lesions of cerebral atherosclerosis from induced hypertension in Watanabe heritable hyperlipidemic rabbits. ( 11193506 )
2000
42
The influence of the degree of cerebral atherosclerosis on the changes in hemostatic system in patients with ischemic brain disease and atherosclerotic encephalopathy. ( 10645149 )
1999
43
Relation of plasma homocyst(e)ine to cerebral infarction and cerebral atherosclerosis. ( 9836754 )
1998
44
Cerebral atherosclerosis in Parkinsonian patients. ( 18591095 )
1998
45
Granule-laden perivascular cells observed in rabbits with experimental cerebral atherosclerosis. ( 8619506 )
1996
46
The lipoprotein profile of young adults with cerebral atherosclerosis. ( 9031424 )
1996
47
Race and sex differences in the distribution of cerebral atherosclerosis. ( 8898801 )
1996
48
Association between deletion polymorphism of the angiotensin-converting enzyme gene and cerebral atherosclerosis. ( 8704045 )
1996
49
Enhancement of the intracranial arterial wall at MR imaging: relationship to cerebral atherosclerosis. ( 7824729 )
1995
50
Pathology of cerebral atherosclerosis. Influence of age, race, and gender. ( 8249014 )
1993

Variations for Cerebral Atherosclerosis

Expression for Cerebral Atherosclerosis

Search GEO for disease gene expression data for Cerebral Atherosclerosis.

Pathways for Cerebral Atherosclerosis

GO Terms for Cerebral Atherosclerosis

Cellular components related to Cerebral Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular vesicle GO:1903561 9.43 APOA1 APOE
2 high-density lipoprotein particle GO:0034364 9.4 APOA1 APOE
3 very-low-density lipoprotein particle GO:0034361 9.37 APOA1 APOE
4 endocytic vesicle lumen GO:0071682 9.32 APOA1 APOE
5 low-density lipoprotein particle GO:0034362 9.26 APOA1 APOE
6 chylomicron GO:0042627 9.16 APOA1 APOE
7 intermediate-density lipoprotein particle GO:0034363 8.96 APOA1 APOE
8 discoidal high-density lipoprotein particle GO:0034365 8.62 APOA1 APOE

Biological processes related to Cerebral Atherosclerosis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cholesterol metabolic process GO:0008203 9.61 APOA1 APOE
2 cholesterol homeostasis GO:0042632 9.6 APOA1 APOE
3 retinoid metabolic process GO:0001523 9.59 APOA1 APOE
4 cholesterol biosynthetic process GO:0006695 9.58 APOA1 APOE
5 triglyceride homeostasis GO:0070328 9.58 APOA1 APOE
6 triglyceride catabolic process GO:0019433 9.57 APOA1 APOE
7 cholesterol efflux GO:0033344 9.56 APOA1 APOE
8 lipoprotein metabolic process GO:0042157 9.55 APOA1 APOE
9 reverse cholesterol transport GO:0043691 9.54 APOA1 APOE
10 high-density lipoprotein particle remodeling GO:0034375 9.52 APOA1 APOE
11 positive regulation of lipid biosynthetic process GO:0046889 9.51 APOA1 APOE
12 high-density lipoprotein particle assembly GO:0034380 9.49 APOA1 APOE
13 phospholipid efflux GO:0033700 9.48 APOA1 APOE
14 chylomicron assembly GO:0034378 9.46 APOA1 APOE
15 very-low-density lipoprotein particle remodeling GO:0034372 9.43 APOA1 APOE
16 positive regulation of cholesterol esterification GO:0010873 9.4 APOA1 APOE
17 high-density lipoprotein particle clearance GO:0034384 9.37 APOA1 APOE
18 chylomicron remodeling GO:0034371 9.32 APOA1 APOE
19 neuron projection regeneration GO:0031102 9.26 APOA1 APOE
20 regulation of cholesterol transport GO:0032374 9.16 APOA1 APOE
21 regulation of Cdc42 protein signal transduction GO:0032489 8.96 APOA1 APOE
22 lipoprotein biosynthetic process GO:0042158 8.62 APOA1 APOE

Molecular functions related to Cerebral Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amyloid-beta binding GO:0001540 9.37 APOA1 APOE
2 cholesterol binding GO:0015485 9.32 APOA1 APOE
3 lipid transporter activity GO:0005319 9.26 APOA1 APOE
4 cholesterol transporter activity GO:0017127 9.16 APOA1 APOE
5 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 8.96 APOA1 APOE
6 lipoprotein particle binding GO:0071813 8.62 APOA1 APOE

Sources for Cerebral Atherosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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