MCID: CRB089
MIFTS: 20

Cerebral Beriberi

Categories: Neuronal diseases

Aliases & Classifications for Cerebral Beriberi

MalaCards integrated aliases for Cerebral Beriberi:

Name: Cerebral Beriberi 53
Wernicke Encephalopathy 71

Classifications:



External Ids:

UMLS 71 C0043121

Summaries for Cerebral Beriberi

NINDS : 53 Wernicke's encephalopathy is a degenerative brain disorder caused by the lack of thiamine (vitamin B1). It may result from alcohol abuse, dietary deficiencies, prolonged vomiting, eating disorders, or the effects of chemotherapy. B1 deficiency causes damage to the brain's thalamus and hypothalamus. Symptoms include mental confusion, vision problems, coma, hypothermia, low blood pressure, and lack of muscle coordination (ataxia). Korsakoff syndrome (also called Korsakoff's amnesic syndrome) is a memory disorder that results from vitamin B1 deficiency and is associated with alcoholism. Korsakoff's syndrome damages nerve cells and supporting cells in the brain and spinal cord, as well as the part of the brain involved with memory. Symptoms include amnesia, tremor, coma, disorientation, and vision problems, The disorder's main features are problems in acquiring new information or establishing new memories, and in retrieving previous memories. Although Wernicke's and Korsakoff's are related disorders, some scientists believe them to be different stages of the same disorder, which is called Wernicke-Korsakoff syndrome. Wernicke's encephalopathy represents the "acute" phase of the disorder and Korsakoff's amnesic syndrome represents the disorder progressing to a "chronic" or long-lasting stage.

MalaCards based summary : Cerebral Beriberi, also known as wernicke encephalopathy, is related to beriberi and wernicke encephalopathy. The drugs Ethanol and Magnesium Sulfate have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and thalamus.

Related Diseases for Cerebral Beriberi

Diseases related to Cerebral Beriberi via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 beriberi 10.3
2 wernicke encephalopathy 10.2
3 encephalopathy 10.2
4 alcohol dependence 9.9
5 kearns-sayre syndrome 9.9

Graphical network of the top 20 diseases related to Cerebral Beriberi:



Diseases related to Cerebral Beriberi

Symptoms & Phenotypes for Cerebral Beriberi

Drugs & Therapeutics for Cerebral Beriberi

Drugs for Cerebral Beriberi (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 2, Phase 3 64-17-5 702
2
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 2, Phase 3 7487-88-9 24083
3
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
4
Histamine Approved, Investigational Phase 3 51-45-6 774
5
Promethazine Approved, Investigational Phase 3 60-87-7 4927
6
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
7 Analgesics Phase 2, Phase 3
8 Tocolytic Agents Phase 2, Phase 3
9 Anti-Arrhythmia Agents Phase 2, Phase 3
10 Anticonvulsants Phase 2, Phase 3
11 calcium channel blockers Phase 2, Phase 3
12 Calcium, Dietary Phase 2, Phase 3
13 Hormones Phase 2, Phase 3
14 Anesthetics, Local Phase 3
15 Central Nervous System Depressants Phase 3
16 Antiemetics Phase 3
17 Gastrointestinal Agents Phase 3
18 Neurotransmitter Agents Phase 3
19 Anesthetics Phase 3
20 Hypnotics and Sedatives Phase 3
21 Dermatologic Agents Phase 3
22 Histamine H1 Antagonists Phase 3
23
Histamine Phosphate Phase 3 51-74-1 65513
24 Histamine Antagonists Phase 3
25 Antipruritics Phase 3
26 Autonomic Agents Phase 3
27 Anti-Allergic Agents Phase 3
28
Dopamine Approved 51-61-6, 62-31-7 681
29
Hydrocortisone acetate Approved, Vet_approved 50-03-3
30
Metoclopramide Approved, Investigational 364-62-5 4168
31
Hydrocortisone Approved, Vet_approved 50-23-7 5754
32
Thiamine Approved, Investigational, Nutraceutical, Vet_approved 70-16-6, 59-43-8 1130
33
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
34 pyruvate
35 Vitamins
36 Thiamin
37 Trace Elements
38 Micronutrients
39 Nutrients
40 Vitamin B Complex
41 Vitamin B9
42 Folate
43 Hydrocortisone hemisuccinate
44 Hydrocortisone-17-butyrate
45 Hydrocortisone 17-butyrate 21-propionate
46 Dopamine D2 Receptor Antagonists
47 Dopamine Agents
48 Dopamine Antagonists
49 Anti-Inflammatory Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimum Thiamine Intervention (OpT In) for Treatment and Prevention of Wernicke-Korsakoff Syndrome (WKS): A Randomised Controlled Trial Completed NCT02788552 Phase 4 Thiamine Hydrochloride
2 A Prospective Randomised Controlled Trial of the Effect of Magnesium Sulphate Administration on Red Cell Transketolase Activity in Alcohol Dependent Patients at Risk of Wernicke Korsakoff Syndrome Treated With Thiamine Completed NCT03466528 Phase 2, Phase 3 Magnesium Sulfate;Pabrinex
3 Comparison Between the Treatment of Thiamine and Promethazine for Improving Vomiting and Nausea in Pregnancy Terminated NCT00861523 Phase 3 thiamine & promethazine
4 From Uncomplicated Alcoholism to Korsakoff's Syndrome: Clinical, Genetic, Neuropsychological and Brain Examinations Unknown status NCT01455207
5 Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study Recruiting NCT03724136
6 Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock Patients: A Prospective Randomized Study Recruiting NCT03649009 Thiamine;Hydrocortisone

Search NIH Clinical Center for Cerebral Beriberi

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Thiamine hydrochloride
Thiamine Mononitrate

Genetic Tests for Cerebral Beriberi

Anatomical Context for Cerebral Beriberi

MalaCards organs/tissues related to Cerebral Beriberi:

40
Brain, Spinal Cord, Thalamus, Hypothalamus, Liver, Lung, Whole Blood

Publications for Cerebral Beriberi

Articles related to Cerebral Beriberi:

(show top 50) (show all 400)
# Title Authors PMID Year
1
Brain 18FDG-PET pattern in patients with alcohol-related cognitive impairment. 61
31428832 2020
2
CLINICAL PRACTICE GUIDELINES FOR THE PERIOPERATIVE NUTRITION, METABOLIC, AND NONSURGICAL SUPPORT OF PATIENTS UNDERGOING BARIATRIC PROCEDURES - 2019 UPDATE: COSPONSORED BY AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS/AMERICAN COLLEGE OF ENDOCRINOLOGY, THE OBESITY SOCIETY, AMERICAN SOCIETY FOR METABOLIC & BARIATRIC SURGERY, OBESITY MEDICINE ASSOCIATION, AND AMERICAN SOCIETY OF ANESTHESIOLOGISTS - EXECUTIVE SUMMARY. 61
31682518 2019
3
Wernicke encephalopathy associated with hyperemesis gravidarum. 61
31784394 2019
4
A Case of Ascending Sensory Neuropathy Due to Acute Onset Thiamine Deficiency After Intragastric Balloon Placement. 61
31134479 2019
5
Wernicke encephalopathy following gastrojejunostomy: A case report and review of the literature. 61
31687617 2019
6
Malnutrition in the elderly and Wernicke encephalopathy. 61
28363380 2019
7
Subclinical thiamine deficiency identified by preoperative evaluation in an ovarian cancer patient: Diagnosis and the need for preoperative thiamine measurement. 61
30168403 2019
8
Functional neurological symptoms masquerading as Wernicke encephalopathy following bariatric surgery. 61
31656438 2019
9
Thiamine Deficiency in a Child with Short Bowel Syndrome and Review. 61
31555575 2019
10
Rapid same-day resolution of internuclear ophthalmoplegia in Wernicke encephalopathy following parenteral high dose thiamine. 61
31712022 2019
11
Vision Loss As a Presenting Feature of Wernicke Encephalopathy. 61
30829946 2019
12
Nausea and vomiting of pregnancy and hyperemesis gravidarum. 61
31515515 2019
13
Posterior reversible encephalopathy syndrome and Wernicke encephalopathy in patient with acute graft-versus-host disease. 61
31193981 2019
14
Ataxia. 61
31356292 2019
15
Alcohol Induced Wernicke Encephalopathy with Atypical MRI Findings. 61
31565609 2019
16
FDG PET/MRI Findings Pointing Toward a Gayet-Wernicke Encephalopathy. 61
31058688 2019
17
Wernicke Encephalopathy-Clinical Pearls. 61
31171116 2019
18
Hypothalamic sydrome as an initial presentation of Wernicke encephalopathy: A case report. 61
31261554 2019
19
Wernicke's Encephalopathy Accompanying Acute Axonal Polyneuropathy: A Case Report. 61
31223251 2019
20
Wernicke's encephalopathy in hyperemesis gravidarum: A systematic review. 61
30889425 2019
21
Non-alcoholic Wernicke encephalopathy presenting as bilateral hearing loss: a case report. 61
30729314 2019
22
Wernicke encephalopathy hearing loss and palinacousis. 61
30957373 2019
23
A RARE CASE OF PRIMARY HYPERPARATHYROIDISM, HYPEREMESIS GRAVIDARUM, AND WERNICKE ENCEPHALOPATHY. 61
31967013 2019
24
Wernicke encephalopathy concurrent with polyradiculoneuropathy in a young man after bariatric surgery: A case report. 61
30855500 2019
25
[Bilateral loss of the horizontal vestibulo-ocular reflex in Wernicke encephalopathy - a specific and early clinical sign]. 61
30694522 2019
26
Thiamine Substitution in Alcohol Use Disorder: A Narrative Review of Medical Guidelines. 61
30897571 2019
27
An autopsied case of MM1-type sporadic Creutzfeldt-Jakob disease with pathology of Wernicke encephalopathy. 61
30409087 2019
28
Dracula teeth-like image on MRI of a patient with non alcoholic Wernicke encephalopathy. 61
30453205 2019
29
[Etiology and Treatment of Delirium]. 61
30674058 2019
30
A Case of Wernicke Encephalopathy Developing After Ileal Bypass Surgery. 61
29596284 2018
31
Wernicke encephalopathy without delirium that appeared as agitation in a patient with lung cancer. 61
29747720 2018
32
Non-alcoholic Wernicke encephalopathy: great masquerader. 61
30593527 2018
33
Isolated Mammillary Bodies Damage-An Atypical Presentation of Wernicke Syndrome. 61
30424509 2018
34
Optic Chiasm Involvement With Concurrent Typical Wernicke Encephalopathy Magnetic Resonance Findings: A Case Report. 61
29029866 2018
35
Wernicke Encephalopathy with Atypical Findings on Magnetic Resonance Imaging. 61
30532369 2018
36
Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis. 61
30281514 2018
37
Conversion of upbeat to downbeat nystagmus in Wernicke encephalopathy. 61
30348852 2018
38
Missing the early signs of thiamine deficiency. A case associated with a liquid-only diet. 61
30092713 2018
39
Wernicke encephalopathy in a lung cancer patient during treatment with nivolumab. 61
30073944 2018
40
Subclinical thiamine deficiency in patients with abdominal cancer. 61
29277168 2018
41
Prevalence and predictors of postoperative thiamine deficiency after vertical sleeve gastrectomy. 61
29803410 2018
42
Clinical Characteristics and Outcomes Associated With High-Dose Intravenous Thiamine Administration in Patients With Encephalopathy. 61
29482863 2018
43
Wernicke Encephalopathy Due to Hyperemesis Gravidarum in Pregnancy: A Case Report. 61
30237950 2018
44
Preventing Wernicke Encephalopathy After Bariatric Surgery. 61
29693218 2018
45
Wernicke encephalopathy: (MRI) picture worth a thousand words. 61
29868178 2018
46
Vitamin B1 Deficiency Related to Excessive Soft Drink Consumption in Japan. 61
29176478 2018
47
Wernicke Encephalopathy Following Laparoscopic Sleeve Gastrectomy-a Call to Evaluate Thiamine Deficiencies After Restrictive Bariatric Procedures. 61
29307105 2018
48
[A case of Wernicke encephalopathy with hypoacusia and MR high intensity of the inferior colliculi that normalized after thiamine administration]. 61
29386493 2018
49
Wernicke encephalopathy without delirium in patients with cancer. 61
28464962 2018
50
Central Lesions With Selective Semicircular Canal Involvement Mimicking Bilateral Vestibulopathy. 61
29740388 2018

Variations for Cerebral Beriberi

Expression for Cerebral Beriberi

Search GEO for disease gene expression data for Cerebral Beriberi.

Pathways for Cerebral Beriberi

GO Terms for Cerebral Beriberi

Sources for Cerebral Beriberi

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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