MCID: CRB089
MIFTS: 20

Cerebral Beriberi

Categories: Neuronal diseases

Aliases & Classifications for Cerebral Beriberi

MalaCards integrated aliases for Cerebral Beriberi:

Name: Cerebral Beriberi 54
Wernicke Encephalopathy 72

Classifications:



External Ids:

UMLS 72 C0043121

Summaries for Cerebral Beriberi

NINDS : 54 Wernicke's encephalopathy is a degenerative brain disorder caused by the lack of thiamine (vitamin B1). It may result from alcohol abuse, dietary deficiencies, prolonged vomiting, eating disorders, or the effects of chemotherapy. B1 deficiency causes damage to the brain's thalamus and hypothalamus. Symptoms include mental confusion, vision problems, coma, hypothermia, low blood pressure, and lack of muscle coordination (ataxia). Korsakoff syndrome (also called Korsakoff's amnesic syndrome) is a memory disorder that results from vitamin B1 deficiency and is associated with alcoholism. Korsakoff's syndrome damages nerve cells and supporting cells in the brain and spinal cord, as well as the part of the brain involved with memory. Symptoms include amnesia, tremor, coma, disorientation, and vision problems, The disorder's main features are problems in acquiring new information or establishing new memories, and in retrieving previous memories. Although Wernicke's and Korsakoff's are related disorders, some scientists believe them to be different stages of the same disorder, which is called Wernicke-Korsakoff syndrome. Wernicke's encephalopathy represents the "acute" phase of the disorder and Korsakoff's amnesic syndrome represents the disorder progressing to a "chronic" or long-lasting stage.

MalaCards based summary : Cerebral Beriberi, also known as wernicke encephalopathy, is related to beriberi and wernicke encephalopathy. The drugs Ethanol and Magnesium Sulfate have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and hypothalamus.

Related Diseases for Cerebral Beriberi

Diseases related to Cerebral Beriberi via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 beriberi 10.3
2 wernicke encephalopathy 10.2
3 encephalopathy 10.2
4 alcohol dependence 9.9
5 kearns-sayre syndrome 9.9

Graphical network of the top 20 diseases related to Cerebral Beriberi:



Diseases related to Cerebral Beriberi

Symptoms & Phenotypes for Cerebral Beriberi

Drugs & Therapeutics for Cerebral Beriberi

Drugs for Cerebral Beriberi (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 2, Phase 3 64-17-5 702
2
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 2, Phase 3 7487-88-9 24083
3
Promethazine Approved, Investigational Phase 3 60-87-7 4927
4
Histamine Approved, Investigational Phase 3 51-45-6 774
5
Diphenhydramine Approved, Investigational Phase 3 58-73-1, 147-24-0 3100
6
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
7 Analgesics Phase 2, Phase 3
8 Hormones Phase 2, Phase 3
9 Tocolytic Agents Phase 2, Phase 3
10 Anti-Arrhythmia Agents Phase 2, Phase 3
11 Anticonvulsants Phase 2, Phase 3
12 Calcium, Dietary Phase 2, Phase 3
13 calcium channel blockers Phase 2, Phase 3
14 Neurotransmitter Agents Phase 3
15 Anesthetics, Local Phase 3
16 Anti-Allergic Agents Phase 3
17 Central Nervous System Depressants Phase 3
18 Gastrointestinal Agents Phase 3
19 Antiemetics Phase 3
20 Peripheral Nervous System Agents Phase 3
21 Histamine H1 Antagonists Phase 3
22 Histamine Antagonists Phase 3
23 Hypnotics and Sedatives Phase 3
24 Dermatologic Agents Phase 3
25 Anesthetics Phase 3
26
Histamine Phosphate Phase 3 51-74-1 65513
27 Antipruritics Phase 3
28 Autonomic Agents Phase 3
29
Dopamine Approved 51-61-6, 62-31-7 681
30
Metoclopramide Approved, Investigational 364-62-5 4168
31
Hydrocortisone Approved, Vet_approved 50-23-7 5754
32
Hydrocortisone acetate Approved, Vet_approved 50-03-3
33
Thiamine Approved, Investigational, Nutraceutical, Vet_approved 59-43-8, 70-16-6 1130
34
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
35 pyruvate
36 Vitamins
37 Thiamin
38 Micronutrients
39 Trace Elements
40 Vitamin B9
41 Vitamin B Complex
42 Folate
43 Nutrients
44 Anti-Inflammatory Agents
45 Dopamine Agents
46 Hydrocortisone-17-butyrate
47 Dopamine Antagonists
48 Hydrocortisone 17-butyrate 21-propionate
49 Hydrocortisone hemisuccinate
50 Dopamine D2 Receptor Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimum Thiamine Intervention (OpT In) for Treatment and Prevention of Wernicke-Korsakoff Syndrome (WKS): A Randomised Controlled Trial Completed NCT02788552 Phase 4 Thiamine Hydrochloride
2 A Prospective Randomised Controlled Trial of the Effect of Magnesium Sulphate Administration on Red Cell Transketolase Activity in Alcohol Dependent Patients at Risk of Wernicke Korsakoff Syndrome Treated With Thiamine Completed NCT03466528 Phase 2, Phase 3 Magnesium Sulfate;Pabrinex
3 Comparison Between the Treatment of Thiamine and Promethazine for Improving Vomiting and Nausea in Pregnancy Terminated NCT00861523 Phase 3 thiamine & promethazine
4 From Uncomplicated Alcoholism to Korsakoff's Syndrome: Clinical, Genetic, Neuropsychological and Brain Examinations Unknown status NCT01455207
5 Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study Recruiting NCT03724136
6 Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock Patients: A Prospective Randomized Study Recruiting NCT03649009 Thiamine;Hydrocortisone

Search NIH Clinical Center for Cerebral Beriberi

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Thiamine hydrochloride
Thiamine Mononitrate

Genetic Tests for Cerebral Beriberi

Anatomical Context for Cerebral Beriberi

MalaCards organs/tissues related to Cerebral Beriberi:

41
Brain, Spinal Cord, Hypothalamus, Thalamus, Liver, Lung, Whole Blood

Publications for Cerebral Beriberi

Articles related to Cerebral Beriberi:

(show top 50) (show all 392)
# Title Authors PMID Year
1
Vision Loss As a Presenting Feature of Wernicke Encephalopathy. 38
30829946 2019
2
Brain 18FDG-PET pattern in patients with alcohol-related cognitive impairment. 38
31428832 2019
3
Posterior reversible encephalopathy syndrome and Wernicke encephalopathy in patient with acute graft-versus-host disease. 38
31193981 2019
4
Ataxia. 38
31356292 2019
5
FDG PET/MRI Findings Pointing Toward a Gayet-Wernicke Encephalopathy. 38
31058688 2019
6
Wernicke Encephalopathy-Clinical Pearls. 38
31171116 2019
7
Wernicke's Encephalopathy Accompanying Acute Axonal Polyneuropathy: A Case Report. 38
31223251 2019
8
Hypothalamic sydrome as an initial presentation of Wernicke encephalopathy: A case report. 38
31261554 2019
9
A Case of Ascending Sensory Neuropathy Due to Acute Onset Thiamine Deficiency After Intragastric Balloon Placement. 38
31134479 2019
10
Wernicke's encephalopathy in hyperemesis gravidarum: A systematic review. 38
30889425 2019
11
Non-alcoholic Wernicke encephalopathy presenting as bilateral hearing loss: a case report. 38
30729314 2019
12
Wernicke encephalopathy hearing loss and palinacousis. 38
30957373 2019
13
Wernicke encephalopathy concurrent with polyradiculoneuropathy in a young man after bariatric surgery: A case report. 38
30855500 2019
14
An autopsied case of MM1-type sporadic Creutzfeldt-Jakob disease with pathology of Wernicke encephalopathy. 38
30409087 2019
15
[Bilateral loss of the horizontal vestibulo-ocular reflex in Wernicke encephalopathy - a specific and early clinical sign]. 38
30694522 2019
16
Thiamine Substitution in Alcohol Use Disorder: A Narrative Review of Medical Guidelines. 38
30897571 2019
17
Dracula teeth-like image on MRI of a patient with non alcoholic Wernicke encephalopathy. 38
30453205 2019
18
[Etiology and Treatment of Delirium]. 38
30674058 2019
19
Wernicke encephalopathy without delirium that appeared as agitation in a patient with lung cancer. 38
29747720 2018
20
A Case of Wernicke Encephalopathy Developing After Ileal Bypass Surgery. 38
29596284 2018
21
Non-alcoholic Wernicke encephalopathy: great masquerader. 38
30593527 2018
22
Isolated Mammillary Bodies Damage-An Atypical Presentation of Wernicke Syndrome. 38
30424509 2018
23
Optic Chiasm Involvement With Concurrent Typical Wernicke Encephalopathy Magnetic Resonance Findings: A Case Report. 38
29029866 2018
24
Wernicke Encephalopathy with Atypical Findings on Magnetic Resonance Imaging. 38
30532369 2018
25
Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis. 38
30281514 2018
26
Conversion of upbeat to downbeat nystagmus in Wernicke encephalopathy. 38
30348852 2018
27
Subclinical thiamine deficiency in patients with abdominal cancer. 38
29277168 2018
28
Missing the early signs of thiamine deficiency. A case associated with a liquid-only diet. 38
30092713 2018
29
Wernicke encephalopathy in a lung cancer patient during treatment with nivolumab. 38
30073944 2018
30
Subclinical thiamine deficiency identified by preoperative evaluation in an ovarian cancer patient: Diagnosis and the need for preoperative thiamine measurement. 38
30168403 2018
31
Preventing Wernicke Encephalopathy After Bariatric Surgery. 38
29693218 2018
32
Wernicke Encephalopathy Due to Hyperemesis Gravidarum in Pregnancy: A Case Report. 38
30237950 2018
33
Clinical Characteristics and Outcomes Associated With High-Dose Intravenous Thiamine Administration in Patients With Encephalopathy. 38
29482863 2018
34
Prevalence and predictors of postoperative thiamine deficiency after vertical sleeve gastrectomy. 38
29803410 2018
35
Wernicke encephalopathy: (MRI) picture worth a thousand words. 38
29868178 2018
36
Vitamin B1 Deficiency Related to Excessive Soft Drink Consumption in Japan. 38
29176478 2018
37
Wernicke Encephalopathy Following Laparoscopic Sleeve Gastrectomy-a Call to Evaluate Thiamine Deficiencies After Restrictive Bariatric Procedures. 38
29307105 2018
38
[A case of Wernicke encephalopathy with hypoacusia and MR high intensity of the inferior colliculi that normalized after thiamine administration]. 38
29386493 2018
39
Wernicke encephalopathy without delirium in patients with cancer. 38
28464962 2018
40
Central Lesions With Selective Semicircular Canal Involvement Mimicking Bilateral Vestibulopathy. 38
29740388 2018
41
Toxic-induced cerebellar syndrome: from the fetal period to the elderly. 38
29891070 2018
42
Convergence Spasm in Wernicke Encephalopathy. 38
29276567 2018
43
Polyneuropathy, Myocardial Dysfunction and Pericardial Effusion Following Duodenal Switch. 38
30543517 2018
44
Postseizure aphasia in Wernicke's encephalopathy: a case report and review of literature. 38
30349257 2018
45
Epileptic seizures in nonalcoholic Wernicke's encephalopathy: a case report and literature review. 38
28875427 2017
46
A case report: Non-alcoholic Wernicke encephalopathy associated with polyneuropathy. 38
28367669 2017
47
A rare complication of vomiting in pregnancy: Wernicke encephalopathy. 38
28456382 2017
48
Wernicke encephalopathy in a patient after liver transplantation: A case report. 38
29308003 2017
49
Wernicke encephalopathy as initial presentation of lymphoma. 38
26805632 2017
50
Wernicke Encephalopathy in a Patient with Pulmonary and Abdominal Tuberculosis. 38
29133769 2017

Variations for Cerebral Beriberi

Expression for Cerebral Beriberi

Search GEO for disease gene expression data for Cerebral Beriberi.

Pathways for Cerebral Beriberi

GO Terms for Cerebral Beriberi

Sources for Cerebral Beriberi

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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