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MCID: CRB089
MIFTS: 22

Cerebral Beriberi

Categories: Neuronal diseases
Tissues Related diseases Publications Drugs
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Aliases & Classifications for Cerebral Beriberi

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MalaCards integrated aliases for Cerebral Beriberi:

Name: Cerebral Beriberi 55
Wernicke Encephalopathy 74

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

UMLS 74 C0043121
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Summaries for Cerebral Beriberi

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NINDS : 55 Wernicke's encephalopathy is a degenerative brain disorder caused by the lack of thiamine (vitamin B1). It may result from alcohol abuse, dietary deficiencies, prolonged vomiting, eating disorders, or the effects of chemotherapy. B1 deficiency causes damage to the brain's thalamus and hypothalamus. Symptoms include mental confusion, vision problems, coma, hypothermia, low blood pressure, and lack of muscle coordination (ataxia). Korsakoff syndrome (also called Korsakoff's amnesic syndrome) is a memory disorder that results from vitamin B1 deficiency and is associated with alcoholism. Korsakoff's syndrome damages nerve cells and supporting cells in the brain and spinal cord, as well as the part of the brain involved with memory. Symptoms include amnesia, tremor, coma, disorientation, and vision problems, The disorder's main features are problems in acquiring new information or establishing new memories, and in retrieving previous memories. Although Wernicke's and Korsakoff's are related disorders, some scientists believe them to be different stages of the same disorder, which is called Wernicke-Korsakoff syndrome. Wernicke's encephalopathy represents the "acute" phase of the disorder and Korsakoff's amnesic syndrome represents the disorder progressing to a "chronic" or long-lasting stage.

MalaCards based summary : Cerebral Beriberi, also known as wernicke encephalopathy, is related to beriberi and wernicke encephalopathy. The drugs Thiamine and Folic Acid have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and hypothalamus.

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Related Diseases for Cerebral Beriberi

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Diseases related to Cerebral Beriberi via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 beriberi 10.1
2 wernicke encephalopathy 10.1
3 encephalopathy 10.1

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Symptoms & Phenotypes for Cerebral Beriberi

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Drugs & Therapeutics for Cerebral Beriberi

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Drugs for Cerebral Beriberi (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 70-16-6, 59-43-8 1130
2
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
3 Vitamins Phase 4,Phase 2,Phase 3,Not Applicable
4 Thiamin Phase 4,Phase 2,Phase 3,Not Applicable
5 Nutrients Phase 4,Phase 2,Phase 3
6 Vitamin B Complex Phase 4,Phase 2,Phase 3
7 Trace Elements Phase 4,Phase 2,Phase 3
8 Micronutrients Phase 4,Phase 2,Phase 3
9 Vitamin B9 Phase 4,Phase 2,Phase 3
10 Folate Phase 4,Phase 2,Phase 3
11
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 2, Phase 3 7487-88-9 24083
12
Ethanol Approved Phase 2, Phase 3 64-17-5 702
13
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
14
Promethazine Approved, Investigational Phase 3 60-87-7 4927
15
Histamine Approved, Investigational Phase 3 51-45-6 774
16
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
17 Analgesics Phase 2, Phase 3
18 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3
19 Gastrointestinal Agents Phase 3
20 Anticonvulsants Phase 2, Phase 3
21 Calcium, Dietary Phase 2, Phase 3
22 Anesthetics Phase 2, Phase 3,Phase 3
23 calcium channel blockers Phase 2, Phase 3
24 Anti-Arrhythmia Agents Phase 2, Phase 3
25 Hormones Phase 2, Phase 3
26 Central Nervous System Depressants Phase 2, Phase 3,Phase 3
27 Tocolytic Agents Phase 2, Phase 3
28 Anti-Allergic Agents Phase 3
29
Histamine Phosphate Phase 3 51-74-1 65513
30 Autonomic Agents Phase 3
31 Neurotransmitter Agents Phase 3
32 Histamine H1 Antagonists Phase 3
33 Anesthetics, Local Phase 3
34 Antiemetics Phase 3
35 Antipruritics Phase 3
36 Dermatologic Agents Phase 3
37 Histamine Antagonists Phase 3
38 Hypnotics and Sedatives Phase 3
39
Etanercept Approved, Investigational 185243-69-0
40
Tofacitinib Approved, Investigational 477600-75-2
41 pyruvate Not Applicable
42 Anti-Inflammatory Agents
43 Immunosuppressive Agents
44 Anti-Inflammatory Agents, Non-Steroidal
45 Immunologic Factors
46 Analgesics, Non-Narcotic
47 Antirheumatic Agents
48 Protein Kinase Inhibitors

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Optimum Thiamine Intervention (OpTIn) Trial Recruiting NCT02788552 Phase 4 Thiamine Hydrochloride
2 Alcohol: Thiamine and or Magnesium 1 Recruiting NCT03466528 Phase 2, Phase 3 Magnesium Sulfate;Pabrinex
3 An Efficacy and Safety Trial of Fedratinib in Subjects With DIPSS, Intermediate or High-Risk Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib Recruiting NCT03755518 Phase 3 FEDRATINIB
4 An Efficacy and Safety Study of Fedratinib Compared to Best Available Therapy in Subjects With DIPSS-intermediate or High-risk Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, or Post-essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib Not yet recruiting NCT03952039 Phase 3 FEDRATINIB;Best Available Therapy (BAT)
5 Does Thiamine Help Vomiting and Nausea in Pregnancy? Terminated NCT00861523 Phase 3 thiamine & promethazine
6 Bilateral Repetitive Transcranial Magnetic Stimulation for Auditory Hallucinations Unknown status NCT00567281 Phase 2
7 Transcranial Magnetic Stimulation for "Voices" Completed NCT00308997 Phase 2
8 A Study of NCS-01 in Patients With Acute Ischemic Stroke Not yet recruiting NCT03915431 Phase 1, Phase 2
9 Study of the Effect of Transcranial Stimulations in Aphasic Subject Within a Year of Their Stroke Unknown status NCT02101398 Not Applicable
10 From Uncomplicated Alcoholism to Korsakoff's Syndrome Unknown status NCT01455207 Not Applicable
11 A Study To Evaluate The Efficacy Of Enbrel (REGISTERED) Etanercept Over A Period Of 12 Months In The Routine Treatment Of Patients With Rheumatoid Arthritis, Axial Spondyloarthritis, Psoriatic Arthritis, Or Plaque Psoriasis. Completed NCT02486302 Etanercept
12 Models of Disordered Knowledge and Memory Systems in Dementia and Related Disorders Completed NCT00004557
13 MRI and Diffusion Imaging of Eloquent Brain Areas to Optimize Brain Tumor Resection Planning Recruiting NCT01534104 Not Applicable
14 Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study Recruiting NCT03724136 Not Applicable
15 Modeling Treated Recovery From Aphasia Recruiting NCT03416738 Not Applicable
16 Observational Study to Determine How Physicians Make Treatment Decisions in Patients Treated With Tofacitinib for Moderate to Severe Active Rheumatoid Arthritis Recruiting NCT03387423 Tofacitinib
17 Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimer Disease Active, not recruiting NCT03270137 Not Applicable
18 The Effect of tDCS on Subcortical Brain Functioning Terminated NCT01602276 Not Applicable

Search NIH Clinical Center for Cerebral Beriberi

Inferred drug relations via UMLS 74 / NDF-RT 52 :
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Genetic Tests for Cerebral Beriberi

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Anatomical Context for Cerebral Beriberi

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MalaCards organs/tissues related to Cerebral Beriberi:

42
Brain, Spinal Cord, Hypothalamus, Thalamus, Liver, Lung, T Cells
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Publications for Cerebral Beriberi

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Articles related to Cerebral Beriberi:

(show top 50) (show all 208)
# Title Authors Year
1
An autopsied case of MM1-type sporadic Creutzfeldt-Jakob disease with pathology of Wernicke encephalopathy. ( 30409087 )
2019
2
FDG PET/MRI Findings Pointing Toward a Gayet-Wernicke Encephalopathy. ( 31058688 )
2019
3
Wernicke encephalopathy hearing loss and palinacousis. ( 30957373 )
2019
4
Non-alcoholic Wernicke encephalopathy presenting as bilateral hearing loss: a case report. ( 30729314 )
2019
5
Vision Loss As a Presenting Feature of Wernicke Encephalopathy. ( 30829946 )
2019
6
Wernicke encephalopathy concurrent with polyradiculoneuropathy in a young man after bariatric surgery: A case report. ( 30855500 )
2019
7
Non-alcoholic Wernicke encephalopathy: great masquerader. ( 30593527 )
2018
8
Dracula teeth-like image on MRI of a patient with non alcoholic Wernicke encephalopathy. ( 30453205 )
2018
9
Wernicke Encephalopathy with Atypical Findings on Magnetic Resonance Imaging. ( 30532369 )
2018
10
Wernicke Encephalopathy Due to Hyperemesis Gravidarum in Pregnancy: A Case Report. ( 30237950 )
2018
11
Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis. ( 30281514 )
2018
12
Conversion of upbeat to downbeat nystagmus in Wernicke encephalopathy. ( 30348852 )
2018
13
Wernicke encephalopathy in a lung cancer patient during treatment with nivolumab. ( 30073944 )
2018
14
Wernicke encephalopathy: (MRI) picture worth a thousand words. ( 29868178 )
2018
15
Preventing Wernicke Encephalopathy After Bariatric Surgery. ( 29693218 )
2018
16
Wernicke encephalopathy without delirium that appeared as agitation in a patient with lung cancer. ( 29747720 )
2018
17
A Case of Wernicke Encephalopathy Developing After Ileal Bypass Surgery. ( 29596284 )
2018
18
Convergence Spasm in Wernicke Encephalopathy. ( 29276567 )
2018
19
Wernicke Encephalopathy Following Laparoscopic Sleeve Gastrectomy-a Call to Evaluate Thiamine Deficiencies After Restrictive Bariatric Procedures. ( 29307105 )
2018
20
Optic Chiasm Involvement With Concurrent Typical Wernicke Encephalopathy Magnetic Resonance Findings: A Case Report. ( 29029866 )
2018
21
Wernicke encephalopathy without delirium in patients with cancer. ( 28464962 )
2018
22
Wernicke Encephalopathy in a Patient with Pulmonary and Abdominal Tuberculosis. ( 29133769 )
2017
23
A patient with a 'typical presentation' of Wernicke encephalopathy was found to have sporadic Creutzfeldt-Jakob disease. ( 28653943 )
2017
24
Wernicke encephalopathy in a patient after liver transplantation: A case report. ( 29308003 )
2017
25
Fundus Findings in Wernicke Encephalopathy. ( 28924437 )
2017
26
Hypomagnesaemia as a trigger of relapsing non-alcoholic Wernicke encephalopathy: a case report. ( 28730572 )
2017
27
More than a Case Report? Should Wernicke Encephalopathy After Sleeve Gastrectomy be a Concern? ( 28733807 )
2017
28
Differences Between Alcoholic and Nonalcoholic Patients With Wernicke Encephalopathy: A Multicenter Observational Study. ( 28578781 )
2017
29
A rare complication of vomiting in pregnancy: Wernicke encephalopathy. ( 28456382 )
2017
30
Hypothermia Presenting in Wernicke Encephalopathy: A Case Report. ( 28289649 )
2017
31
Malnutrition in the elderly and Wernicke encephalopathy. ( 28363380 )
2017
32
A case report: Non-alcoholic Wernicke encephalopathy associated with polyneuropathy. ( 28367669 )
2017
33
Delayed diagnosis of Wernicke encephalopathy with irreversible neural damage after subtotal gastrectomy for gastric cancer: A case of medical liability? ( 27988455 )
2017
34
Sleeve Gastrectomy and Wernicke Encephalopathy. ( 27415978 )
2017
35
Wernicke encephalopathy and systemic sclerosis: rare association of rare conditions. ( 27590483 )
2017
36
Wernicke encephalopathy as initial presentation of lymphoma. ( 26805632 )
2017
37
Cerebral vasospasm and wernicke encephalopathy secondary to adult cyclic vomiting syndrome: the role of magnesium. ( 27515947 )
2016
38
Wernicke Encephalopathy after Restrictive Bariatric Surgery: A Significant Increase of a Rare Complication. ( 28234175 )
2016
39
Wernicke Encephalopathy in Adolescents After Bariatric Surgery: Case Report and Review. ( 27940680 )
2016
40
Wernicke encephalopathy: SWI detects petechial hemorrhages in mammillary bodies in vivo. ( 27799475 )
2016
41
Cerebral salt-wasting syndrome in a child with Wernicke encephalopathy treated with fludrocortisone therapy: A case report. ( 27603336 )
2016
42
Magnetic Resonance Imaging and H-proton Spectroscopy assessment of maternal and foetal brains in a case of pregnancy-associated Wernicke encephalopathy. ( 27624910 )
2016
43
Nonalcoholic Wernicke Encephalopathy: An Entity Not to Be Missed! ( 27670213 )
2016
44
Wernicke encephalopathy in a patient with liver failure: Clinical case report. ( 27399058 )
2016
45
Gayet-Wernicke encephalopathy: A rare and serious complication of gastrointestinal involvement in HIV infection. ( 27079166 )
2016
46
Wernicke Encephalopathy after Restrictive Bariatric Surgery. ( 27097609 )
2016
47
Non-alcoholic Wernicke Encephalopathy. ( 26787276 )
2016
48
Challenges in Diagnosis and Treatment of Wernicke Encephalopathy: Report of 2 Cases. ( 26869612 )
2016
49
Early detection and successful treatment of Wernicke encephalopathy in a patient with advanced carcinoma of the external genitalia during chemotherapy. ( 26653343 )
2016
50
Wernicke Encephalopathy: a Future Problem Even After Sleeve Gastrectomy? A Systematic Literature Review. ( 26476834 )
2016
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Variations for Cerebral Beriberi

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Expression for Cerebral Beriberi

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Search GEO for disease gene expression data for Cerebral Beriberi.
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Pathways for Cerebral Beriberi

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GO Terms for Cerebral Beriberi

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Sources for Cerebral Beriberi

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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