Cerebral Degeneration disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CRB033 MIFTS: 42	Cerebral Degeneration Categories: Neuronal diseases
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Aliases & Classifications for Cerebral Degeneration

MalaCards integrated aliases for Cerebral Degeneration:

Name: Cerebral Degeneration ¹² ²⁹ ¹⁵

Degenerative Brain Disorder ⁷³

Brain Degeneration ¹²

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:1443

ICD9CM ³⁵ 331.9

SNOMED-CT ⁶⁸ 154994001 154998003 192824002 more

UMLS ⁷³ C0154671

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Summaries for Cerebral Degeneration

MalaCards based summary : Cerebral Degeneration, also known as degenerative brain disorder, is related to hydrocephalus and leukodystrophy. An important gene associated with Cerebral Degeneration is NOTCH3 (Notch 3), and among its related pathways/superpathways are Neuroscience and Thyroid hormone signaling pathway. The drugs Triamcinolone and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and cortex, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Cerebral Degeneration

Diseases related to Cerebral Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)

#	Related Disease	Score	Top Affiliating Genes
1	hydrocephalus	31.7	GFAP L1CAM PIK3R2 ZIC3
2	leukodystrophy	30.5	ASPA EIF2B2 EIF2B5 FA2H GJC2 PLP1
3	mitochondrial dna depletion syndrome 4a	11.4
4	norrie disease	10.9
5	pseudobulbar palsy	10.8	NOTCH3 NOTCH4
6	niemann-pick disease	10.8
7	porencephaly 2	10.8
8	adrenomyeloneuropathy	10.7	ABCD1 SLC25A17
9	binswanger's disease	10.6	GFAP NOTCH3 PLP1
10	canavan disease	10.6
11	lipid storage disease	10.6
12	pelizaeus-merzbacher-like disease	10.5	GJC2 PLP1
13	megalencephaly	10.5	EIF2B5 MLC1 PIK3R2
14	pelizaeus-merzbacher disease	10.5	GJC2 MLC1 PLP1
15	leukodystrophy, hypomyelinating, 4	10.5	GJC2 PLP1
16	leukodystrophy, hypomyelinating, 2	10.4	FA2H GJC2 PLP1
17	hypomyelinating leukoencephalopathy	10.4	GJC2 PLP1
18	leukoencephalopathy with vanishing white matter	10.4	EIF2B2 EIF2B5 MLC1
19	demyelinating disease	10.4	ABCD1 ABCD2 PLP1
20	cerebritis	10.3
21	spastic paraplegia 2, x-linked	10.3	GJC2 PLP1
22	atypical choroid plexus papilloma	10.2	NOTCH3 NOTCH4
23	adrenoleukodystrophy	10.2	ABCD1 ABCD2 ABCD3 PEX5
24	hereditary spastic paraplegia	10.1	FA2H GJC2 L1CAM PLP1
25	aging	9.9
26	amyotrophic lateral sclerosis 1	9.8
27	lateral sclerosis	9.8
28	neuronitis	9.8
29	trehalase deficiency	9.7	EIF2B5 FA2H GJC2 PIK3R2 PLP1
30	hepatitis	9.7
31	fetal brain disruption sequence	9.7
32	alzheimer disease	9.5
33	acute leukemia	9.5
34	leukemia	9.5
35	liver disease	9.5
36	apraxia	9.5
37	split hand-foot malformation	9.5
38	hemiplegia	9.5
39	bronchopneumonia	9.5
40	dementia	9.5
41	disease of mental health	9.5
42	epilepsy	9.5
43	dysgraphia	9.5
44	herpes simplex	9.5
45	encephalitis	9.5
46	neonatal herpes	9.5
47	encephalopathy	9.5
48	machado-joseph disease	9.5
49	spinocerebellar ataxia 2	9.5
50	wilson disease	9.5

Comorbidity relations with Cerebral Degeneration via Phenotypic Disease Network (PDN): (show all 26)

Acute Cystitis	Alzheimer Disease
Bronchitis	Cerebral Atherosclerosis
Cerebrovascular Disease	Chronic Myocardial Ischemia
Decubitus Ulcer	Deficiency Anemia
Encephalopathy	Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Familial Atrial Fibrillation	Generalized Atherosclerosis
Heart Disease	Hypertension, Essential
Hypothyroidism	Iron Deficiency Anemia
Ischemic Heart Disease	Major Depressive Disorder
Obstructive Hydrocephalus	Osteoporosis
Parkinson Disease, Late-Onset	Protein-Energy Malnutrition
Schizophreniform Disorder	Spinocerebellar Degeneration
Swallowing Disorders	Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Cerebral Degeneration:

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Symptoms & Phenotypes for Cerebral Degeneration

GenomeRNAi Phenotypes related to Cerebral Degeneration according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00173-A	10.13	PIK3R2
2	Decreased viability	GR00221-A-1	10.13	PIK3R2
3	Decreased viability	GR00221-A-2	10.13	PIK3R2
4	Decreased viability	GR00221-A-4	10.13	PIK3R2
5	Decreased viability	GR00240-S-1	10.13	ASAH1
6	Decreased viability	GR00301-A	10.13	PIK3R2
7	Decreased viability	GR00381-A-1	10.13	EIF2B5 FA2H GFAP ASAH1
8	Decreased viability	GR00402-S-2	10.13	FA2H GFAP GJC2 L1CAM MLC1 NOTCH3
9	no effect	GR00402-S-1	9.62	ABCD2 ABCD3 ASAH1 ASPA EIF2B2 EIF2B5

MGI Mouse Phenotypes related to Cerebral Degeneration:

⁴⁶ (show all 12)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.36	ZIC3 ABCD1 ABCD2 ASAH1 ASPA EIF2B5
2	homeostasis/metabolism	MP:0005376	10.28	ABCD1 ABCD2 ABCD3 ASAH1 ASPA EIF2B5
3	growth/size/body region	MP:0005378	10.27	ASAH1 ASPA EIF2B5 GFAP L1CAM MLC1
4	hematopoietic system	MP:0005397	10.21	ABCD1 ASAH1 ASPA EIF2B2 EIF2B5 GJC2
5	cellular	MP:0005384	10.19	ABCD3 ASAH1 GFAP GJC2 L1CAM PLP1
6	nervous system	MP:0003631	10.16	ABCD2 ASAH1 ASPA EIF2B5 FA2H GFAP
7	immune system	MP:0005387	10.11	NOTCH3 PEX5 PLP1 POLG ZIC3 ABCD1
8	endocrine/exocrine gland	MP:0005379	10.08	ABCD1 ABCD2 ASAH1 FA2H MLC1 NOTCH3
9	muscle	MP:0005369	9.87	ASPA GFAP NOTCH3 PEX5 PIK3R2 PLP1
10	reproductive system	MP:0005389	9.81	ABCD1 ASAH1 L1CAM MLC1 NOTCH3 PEX5
11	skeleton	MP:0005390	9.56	ASAH1 ASPA L1CAM NOTCH3 PEX5 PLP1
12	vision/eye	MP:0005391	9.32	ABCD1 ASPA FA2H GFAP GJC2 L1CAM

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Drugs & Therapeutics for Cerebral Degeneration

Drugs for Cerebral Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Triamcinolone

Approved, Vet_approved

Not Applicable

124-94-7

31307

Synonyms:

(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione

11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione

11b,16a,17a,21-Tetrahydroxy-9a-fluoro-1,4-pregnadiene-3,20-dione

11beta,16alpha,17alpha,21-Tetrahydroxy-9alpha-fluoro-1,4-pregnadiene-3,20-dione

11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione

11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione

124-94-7

4-08-00-03629 (Beilstein Handbook Reference)

83474-03-7

9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy

9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione

9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d

9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione

9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone

9a-fluoro-11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9a-fluoro-11b,16a,17a,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9a-fluoro-16a-Hydroxyprednisolone

9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione

9alpha-fluoro-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9alpha-fluoro-11beta,16alpha,17alpha,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9alpha-fluoro-16alpha-Hydroxyprednisolone

9alpha-Fluoro-16alpha-hydroxyprednisolone

9-alpha-Fluoro-16-alpha-hydroxyprednisolone

9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9-fluoro-11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9-fluoro-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione

9α-fluoro-16α-hydroxyprednisolone

AC1L1LDH

AC1Q5HJC

AC-2072

Adcortyl

Aristocort

Aristocort A

Aristocort Tablets

Aristogel

Aristospan

Azmacort

Bio-0662

BPBio1_000154

BRD-K77554836-001-03-3

BRN 2341955

BSPBio_000140

C21H27FO6

Celeste

CHEMBL1451

CID31307

Cinolone

Cinolone-T

CL 19823

D00385

D014221

DB00620

Delphicort

droxypregna-1,4-diene-3,20-dione

EINECS 204-718-7

EU-0101179

Fluoxiprednisolone

Fluoxyprednisolone

Flutex

Fougera

HMS1568G22

HMS2090D12

HSDB 3194

ione

Kenacort

Kenacort (TN)

Kenacort-A

Kenacort-Ag

Kenacort-AG

Kenalog

Kenalog in Orabase

Kenalog-10

Kenalog-40

Kenalog-H

Ledercort

Lopac0_001179

LS-698

MLS000028542

MLS001066543

MLS002695935

MolPort-002-528-981

Mycolog

Nasacort

Nasacort Aq

Nasacort Hfa

NCGC00021580-03

NCGC00021580-04

NCGC00021580-05

NCGC00021580-06

NCGC00021580-07

nchembio.2007.53-comp7

NCI60_000750

NSC 13397

NSC13397

Omcilon

Omicilon

Oracort

Oralone

Orion

Polcortolon

Pregna-1,4-diene-3,20-dio

Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)

Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)

Prestwick_438

Prestwick0_000120

Prestwick1_000120

Prestwick2_000120

Prestwick3_000120

Rodinolone

S1933_Selleck

Sk-Triamcinolone

SK-Triamcinolone

SMP1_000300

SMR000058333

SPBio_002079

T6376_SIGMA

Tiamcinolonum

Tiamcinolonum [INN-Latin]

Triacet

Triacort

Triamcet

Triamcinalone

Triamcinlon

Triamcinolon

Triamcinolona

Triamcinolona [INN-Spanish]

triamcinolone

Triamcinolone (JP15/USP/INN)

TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))

Triamcinolone [USAN:INN:BAN:JAN]

Triamcinolone acetonide

Triamcinolone diacetate

Triamcinolone hexacetonide

Triamcinolonum

Triamcinolonum [INN]

Triam-Tablinen

Triatex

Tricortale

Triderm

Trilone

Tri-Nasal

Tristoject

Trymex

UNII-1ZK20VI6TY

Vetalog

Volon

Volon A

WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ

ZINC03882036

Gastrointestinal Agents

Not Applicable

glucagon

Not Applicable

Glucagon-Like Peptide 1

Not Applicable

Hormone Antagonists

Not Applicable

Hormones

Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Not Applicable

Incretins

Not Applicable

triamcinolone acetonide

Not Applicable

Triamcinolone diacetate

Not Applicable

Triamcinolone hexacetonide

Not Applicable

Fluorodeoxyglucose F18

Not Applicable

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	MRI Biomarkers in ALS	Recruiting	NCT02405182
2	To Determine the Effect of GLP1 on Cognitive Function, Brain Glucose Metabolism and Neuroplasticity.	Recruiting	NCT03414333	Not Applicable	GLP-1
3	Application of Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance	Recruiting	NCT03112902	Not Applicable
4	Responsive Deep Brain Stimulator for Essential Tremor	Recruiting	NCT02649166	Not Applicable
5	Coaching for Cognition in Alzheimer's (COCOA)	Recruiting	NCT03424200	Not Applicable
6	The Motor Network in Essential Tremor: Mechanisms of Therapy	Recruiting	NCT02712515
7	Longitudinal Study of Neurodegenerative Disorders	Recruiting	NCT03333200
8	Early Diagnosis of Alzheimer-like Dementia: Benefit of MRI and PET Imaging	Terminated	NCT01815112	Not Applicable

Search NIH Clinical Center for Cerebral Degeneration

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Genetic Tests for Cerebral Degeneration

Genetic tests related to Cerebral Degeneration:

#	Genetic test	Affiliating Genes
1	Cerebral Degeneration ²⁹

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Anatomical Context for Cerebral Degeneration

MalaCards organs/tissues related to Cerebral Degeneration:

⁴¹

Brain, Liver, Cortex

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Publications for Cerebral Degeneration

Articles related to Cerebral Degeneration:

(show all 40)

#	Title	Authors	Year
1	Cerebral Degeneration in Amyotrophic Lateral Sclerosis Revealed by 3-Dimensional Texture Analysis. ( 27064416 )	Maani R....Kalra S.	2016
2	Split Hand / Foot Malformation Syndrome with Cerebral Degeneration. ( 27730782 )	Mahavar S.K....Sharma R.	2016
3	Proteomic analysis of aging brain in SAMP10 mouse: a model of age-related cerebral degeneration. ( 20471994 )	Furukawa A....Shimada A.	2010
4	Limbic structures are prone to age-related impairments in proteasome activity and neuronal ubiquitinated inclusions in SAMP10 mouse: a model of cerebral degeneration. ( 17973906 )	Shimada A....Hosokawa M.	2008
5	Reduced response of splenocytes after mitogen-stimulation in the prion protein (PrP) gene-deficient mouse: PrPLP/Doppel production and cerebral degeneration. ( 17498663 )	Kim C.K....Onodera T.	2007
6	Cerebral degeneration predicts survival in amyotrophic lateral sclerosis. ( 16835288 )	Kalra S....Arnold D.L.	2006
7	Apical vulnerability to dendritic retraction in prefrontal neurones of ageing SAMP10 mouse: a model of cerebral degeneration. ( 16409548 )	Shimada A....Hosokawa M.	2006
8	Detection of cerebral degeneration in amyotrophic lateral sclerosis using high-field magnetic resonance spectroscopy. ( 16908742 )	Kalra S....Johnston W.S.	2006
9	Age-related loss of synapses in the frontal cortex of SAMP10 mouse: a model of cerebral degeneration. ( 12687639 )	Shimada A....Hosokawa M.	2003
10	Slowly progressive pure dysgraphia with late apraxia of speech: a further variant of the focal cerebral degeneration. ( 14642538 )	Luzzi S....Piccirilli M.	2003
11	Age-related progressive neuronal DNA damage associated with cerebral degeneration in a mouse model of accelerated senescence. ( 12456731 )	Shimada A....Hosokawa M.	2002
12	Progressive cerebral degeneration of childhood with liver disease (Alpers Huttenlocher disease) with cytochrome oxidase deficiency presenting with epilepsia partialis continua as the first clinical manifestation. ( 9561326 )	WAPrle H....Bastanier C.K.	1998
13	Spino-cerebello-cerebral degeneration with amyloid plaques (Gerstmann, StrAoussler, Scheinker syndrome). ( 7151028 )	Dolman C.L....Daly L.L.	1982
14	Cerebral degeneration in Down's syndrome. ( 6459258 )	Gath A.	1981
15	Electroencephalographic studies on hepato-cerebral degeneration. ( 7291928 )	Popoviciu L....SipoA9 C.	1981
16	Multicystic cerebral degeneration in neonatal herpes simplex virus encephalitis. ( 193394 )	Smith J.B....Houser O.W.	1977
17	Infantile diffuse cerebral degeneration with hepatic cirrhosis. ( 1252162 )	Huttenlocher P.R....Adams G.	1976
18	Distribution of cerebral degeneration in Alzheimer's disease. A clinico-pathological study. ( 828039 )	Brun A....Gustafson L.	1976
19	Letter: Adult acute leukemia: cerebral degeneration. ( 4529107 )	Law I.P.	1974
20	Norrie's disease (hereditary oculo-acoustic-cerebral degeneration). Report of a United States family. ( 4201220 )	TOWNES P.L....Roca P.D.	1973
21	Cerebral degeneration with hypertrophy of the contralateral pyramid. ( 5008324 )	Scales D.A....Collins G.H.	1972
22	The old age syndrome: subtle cerebral degeneration and bronchopneumonia. ( 5012283 )	Parker J.C.	1972
23	Norrie's disease. Congenital progressive oculo-acoustico-cerebral degeneration. ( 5000913 )	Fradkin A.H.	1971
24	Combined hepatic and cerebral degeneration in infancy. ( 5667851 )	CAMERON A.H....Wood B.S.	1968
25	On some aspects of cerebral degeneration in later life. ( 20918952 )	Nevin S.	1967
26	Norrie's disease. A congenital progressive oculo-acoustico-cerebral degeneration. ( 6013082 )	Warburg M.	1966
27	Bilateral cherry-red spots without clinical cerebral degeneration. ( 5841578 )	Mednick J....Crowther D.	1965
28	Diffuse cerebral degeneration in infancy (Alpers' disease). ( 13971413 )	BLACKWOOD W....Tucker S.M.	1963
29	Progessive cerebral degeneration of infancy. ( 13792917 )	ALPERS B.J.	1960
30	Affective disorders arising in the senium. I. Their association with organic cerebral degeneration. ( 13243045 )	KAY D.W....HOPKINS B.	1955
31	Rapidly progressive cerebral degeneration (subacute vascular encephalopathy) with mental disorder, focal disturbances, and myoclonic epilepsy. ( 13163708 )	Jones D.P....Nevin S.	1954
32	Heredofamilial infantile cerebral degeneration: the relationship of systemic factors to the pathogenicity. ( 13152645 )	STADLER H.E....Donato A.M.	1954
33	Two Cases of Early Familial Maculo-cerebral Degeneration. ( 19983252 )	Hine M.L.	1923
34	Case of Cerebral Degeneration. ( 19983330 )	Ingleby H.	1923
35	Familial Cerebral Degeneration. ( 19982580 )	Paterson D.	1922
36	Cerebral Degeneration and Epileptiform Fits, with Amaurosis, in an Only Child. ( 19979882 )	Weber F.P.	1917
37	Family Cerebral Degeneration with Macular Changes. ( 19978990 )	Batten F.E....Mayou M.S.	1915
38	Cerebral Degeneration with Changes at the Macula in four members of a family. ( 19973149 )	Mayou M.S.	1908
39	Infantile Cerebral Degeneration with Symmetrical Changes at the Macula. ( 20896909 )	Kingdon E.C....Russell J.S.	1897
40	Case of Grave Lesion of Both Corpora Striata: Recovery from Hemiplegia; Extensive Cerebral Degeneration; Dementia; Death Twelve Days after Rupture of Intrathoracic Aneurism. ( 20748050 )	Mickle W.J.	1875

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Genes for Cerebral Degeneration

Genes related to Cerebral Degeneration (0 elite genes):

(show all 27)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NOTCH3	Notch 3	Protein Coding	19.59	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	NOTCH4	Notch 4	Protein Coding	19.46	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	19.22	DISEASES inferred ¹⁵ ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	ABCD1	ATP Binding Cassette Subfamily D Member 1	Protein Coding	18.76	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	PLP1	Proteolipid Protein 1	Protein Coding	18.68	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	ASAH1	N-Acylsphingosine Amidohydrolase 1	Protein Coding	17.52	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	ZIC3	Zic Family Member 3	Protein Coding	17.44	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	L1CAM	L1 Cell Adhesion Molecule	Protein Coding	17.38	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	MLC1	Megalencephalic Leukoencephalopathy With Subcortical Cysts 1	Protein Coding	17.38	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	POLG	DNA Polymerase Gamma, Catalytic Subunit	Protein Coding	17.35	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	PEX5	Peroxisomal Biogenesis Factor 5	Protein Coding	17.24	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	ABCD3	ATP Binding Cassette Subfamily D Member 3	Protein Coding	17.22	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	EIF2B2	Eukaryotic Translation Initiation Factor 2B Subunit Beta	Protein Coding	17.18	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
14	ASPA	Aspartoacylase	Protein Coding	17.15	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
15	GFAP	Glial Fibrillary Acidic Protein	Protein Coding	17.15	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
16	EIF2B5	Eukaryotic Translation Initiation Factor 2B Subunit Epsilon	Protein Coding	17.12	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
17	GJC2	Gap Junction Protein Gamma 2	Protein Coding	17.02	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
18	FA2H	Fatty Acid 2-Hydroxylase	Protein Coding	17	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
19	SLC25A17	Solute Carrier Family 25 Member 17	Protein Coding	7.59	DISEASES inferred ¹⁵
20	ABCD2	ATP Binding Cassette Subfamily D Member 2	Protein Coding	7.43	DISEASES inferred ¹⁵
21	LMNB1	Lamin B1	Protein Coding	6.92	DISEASES inferred ¹⁵
22	HTRA1	HtrA Serine Peptidase 1	Protein Coding	6.77	DISEASES inferred ¹⁵
23	EIF2B1	Eukaryotic Translation Initiation Factor 2B Subunit Alpha	Protein Coding	6.76	DISEASES inferred ¹⁵
24	ABCD4	ATP Binding Cassette Subfamily D Member 4	Protein Coding	6.63	DISEASES inferred ¹⁵
25	TREX1	Three Prime Repair Exonuclease 1	Protein Coding	6.62	DISEASES inferred ¹⁵
26	POLR3B	RNA Polymerase III Subunit B	Protein Coding	6.53	DISEASES inferred ¹⁵
27	POLR3A	RNA Polymerase III Subunit A	Protein Coding	6.52	DISEASES inferred ¹⁵

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Variations for Cerebral Degeneration

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Expression for Cerebral Degeneration

Search GEO for disease gene expression data for Cerebral Degeneration.

Sources

Pathways for Cerebral Degeneration

Pathways related to Cerebral Degeneration according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ⁴	12.09	GFAP L1CAM NOTCH3 NOTCH4
2	Thyroid hormone signaling pathway ³⁷	11.4	NOTCH3 NOTCH4 PIK3R2
3	Neural Crest Differentiation ¹	11.14	GFAP NOTCH3 NOTCH4
4	Peroxisome ³⁷	10.94	ABCD1 ABCD2 ABCD3 PEX5 SLC25A17

Sources

GO Terms for Cerebral Degeneration

Cellular components related to Cerebral Degeneration according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	myelin sheath	GO:0043209	9.5	GFAP GJC2 PLP1
2	peroxisome	GO:0005777	9.35	ABCD1 ABCD2 ABCD3 PEX5 SLC25A17
3	integral component of peroxisomal membrane	GO:0005779	9.26	ABCD1 SLC25A17
4	eukaryotic translation initiation factor 2B complex	GO:0005851	9.16	EIF2B2 EIF2B5
5	peroxisomal membrane	GO:0005778	9.02	ABCD1 ABCD2 ABCD3 PEX5 SLC25A17

Biological processes related to Cerebral Degeneration according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane transport	GO:0055085	9.89	ABCD1 ABCD2 ABCD3 GJC2 SLC25A17
2	myelination	GO:0042552	9.61	EIF2B2 EIF2B5 PLP1
3	oligodendrocyte development	GO:0014003	9.51	EIF2B2 EIF2B5
4	peroxisome organization	GO:0007031	9.5	ABCD1 ABCD3 PEX5
5	positive regulation of transcription of Notch receptor target	GO:0007221	9.48	NOTCH3 NOTCH4
6	central nervous system myelination	GO:0022010	9.46	ASPA PLP1
7	astrocyte development	GO:0014002	9.43	EIF2B5 GFAP PLP1
8	regulation of developmental process	GO:0050793	9.4	NOTCH3 NOTCH4
9	peroxisomal long-chain fatty acid import	GO:0015910	9.37	ABCD1 ABCD3
10	axon development	GO:0061564	9.33	GFAP L1CAM PLP1
11	very long-chain fatty acid catabolic process	GO:0042760	9.13	ABCD1 ABCD2 ABCD3
12	fatty acid beta-oxidation	GO:0006635	9.02	ABCD1 ABCD2 ABCD3 PEX5 SLC25A17

Molecular functions related to Cerebral Degeneration according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ATPase activity, coupled to transmembrane movement of substances	GO:0042626	9.13	ABCD1 ABCD2 ABCD3
2	long-chain fatty acid transporter activity	GO:0005324	8.8	ABCD1 ABCD2 ABCD3
3	protein binding	GO:0005515	10.09	ABCD1 ABCD2 ABCD3 ASPA EIF2B2 EIF2B5

Sources

Sources for Cerebral Degeneration

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia