Cerebral Degeneration disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CRB033 MIFTS: 42	Cerebral Degeneration Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Cerebral Degeneration

MalaCards integrated aliases for Cerebral Degeneration:

Name: Cerebral Degeneration ¹² ¹⁵

Degenerative Brain Disorder ⁷¹

Brain Degeneration ¹²

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:1443

ICD9CM ³⁴ 331.9

SNOMED-CT ⁶⁷ 52522001 73768007

UMLS ⁷¹ C0154671

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Summaries for Cerebral Degeneration

Disease Ontology : ¹² A brain disease that is characterized by loss of structure or function of neurons, including death of neurons and loss of brain tissue.

MalaCards based summary : Cerebral Degeneration, also known as degenerative brain disorder, is related to leukodystrophy and amyotrophic lateral sclerosis 1. An important gene associated with Cerebral Degeneration is DLG4 (Discs Large MAGUK Scaffold Protein 4), and among its related pathways/superpathways is Peroxisome. The drugs Galantamine and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and cortex, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : ⁷⁴ Neurodegeneration is the progressive loss of structure or function of neurons, including death of... more...

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Related Diseases for Cerebral Degeneration

Diseases related to Cerebral Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)

#	Related Disease	Score	Top Affiliating Genes
1	leukodystrophy	32.5	SLC25A17 PLP1 NOTCH3 GJC2 GFAP EPRS1
2	amyotrophic lateral sclerosis 1	30.9	SERPINA3 PRODH H2AC18 GFAP ERCC6 EPRS1
3	autosomal dominant cerebellar ataxia	30.7	SERPINA3 POLG H2AC18 ERCC6 CRYAA
4	aceruloplasminemia	30.4	SERPINA3 POLG PLA2G6 H2AC18 GFAP
5	retinitis pigmentosa	30.2	PRODH POLG H2AC18 GFAP ERCC6 EPRS1
6	pick disease of brain	29.7	SERPINA3 GFAP DLG4
7	mitochondrial dna depletion syndrome 4a	11.6
8	norrie disease	11.2
9	niemann-pick disease	11.1
10	brain small vessel disease 1 with or without ocular anomalies	11.1
11	brain small vessel disease 2	11.1
12	hydrocephalus	11.1
13	cerebrotendinous xanthomatosis	10.9
14	canavan disease	10.9
15	lipid storage disease	10.9
16	ossifying fibroma	10.8	SERPINA3 NOTCH3 ERCC6
17	binswanger's disease	10.8	PLP1 NOTCH3 GFAP
18	leukodystrophy, hypomyelinating, 5	10.8	PLP1 GJC2 ERCC6
19	adrenomyeloneuropathy	10.7	SLC25A17 ABCD1
20	communicating hydrocephalus	10.7	ZIC3 SERPINA3 ERCC6
21	robinow syndrome, autosomal recessive 1	10.7	H2AC18 ERCC6 EPRS1
22	leukodystrophy, hypomyelinating, 4	10.7	PLP1 GJC2 CRYAA
23	degeneration of macula and posterior pole	10.7	SERPINA3 H2AC18 ERCC6 CRYAA
24	ocular motility disease	10.7	SERPINA3 POLG CRYAA
25	fatal familial insomnia	10.7	SERPINA3 PRODH GFAP ERCC6
26	cranial nerve disease	10.7	SERPINA3 POLG ERCC6 CRYAA
27	xeroderma pigmentosum, complementation group d	10.7	H2AC18 ERCC6 CRYAA
28	lens disease	10.7	SERPINA3 H2AC18 ERCC6 CRYAA
29	mixed cell type cancer	10.7	SERPINA3 PRODH H2AC18
30	toxic encephalopathy	10.7	SERPINA3 H2AC18 GFAP DLG4
31	electroclinical syndrome	10.7	PRODH POLG EPRS1 CRYAA
32	spinal cord disease	10.7	H2AC18 GFAP ABCD1
33	connective tissue cancer	10.7	SERPINA3 H2AC18 ERCC6 CRYAA
34	parasitic protozoa infectious disease	10.7	SERPINA3 PRODH H2AC18 EPRS1
35	alexander disease	10.7	PLP1 GJC2 GFAP CRYAA
36	cerebellar disease	10.7	SERPINA3 POLG H2AC18
37	uveal disease	10.7	SERPINA3 H2AC18 CRYAA
38	optic nerve disease	10.7	SERPINA3 POLG GFAP ERCC6 CRYAA
39	testicular disease	10.7	SERPINA3 H2AC18 ERCC6
40	sphingolipidosis	10.7	SERPINA3 H2AC18 CRYAA
41	amino acid metabolic disorder	10.7	SERPINA3 PRODH H2AC18 EPRS1 CRYAA
42	substance abuse	10.7	SERPINA3 PRODH PLP1 H2AC18
43	congenital nervous system abnormality	10.7	PRODH H2AC18 ERCC6 EPRS1 CRYAA
44	carbohydrate metabolic disorder	10.7	PRODH H2AC18 CRYAA
45	physical disorder	10.7	PRODH H2AC18 ERCC6 EPRS1 CRYAA
46	contractures, pterygia, and variable skeletal fusions syndrome 1a	10.7	SERPINA3 PRODH H2AC18 ERCC6 CRYAA
47	inherited metabolic disorder	10.7	SERPINA3 PRODH H2AC18 EPRS1 CRYAA
48	intestinal benign neoplasm	10.7	SERPINA3 H2AC18 ERCC6
49	immune system disease	10.7	SERPINA3 PRODH H2AC18 EPRS1
50	peroxisome biogenesis disorder 1b	10.7	ZIC3 SLC25A17 ASPA ABCD1

Comorbidity relations with Cerebral Degeneration via Phenotypic Disease Network (PDN): (show all 24)

Acute Cystitis	Alzheimer Disease
Bronchitis	Cerebral Atherosclerosis
Cerebrovascular Disease	Decubitus Ulcer
Deficiency Anemia	Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation	Familial Atrial Fibrillation
Generalized Atherosclerosis	Heart Disease
Hypertension, Essential	Hypothyroidism
Iron Deficiency Anemia	Major Depressive Disorder
Obstructive Hydrocephalus	Osteoporosis
Parkinson Disease, Late-Onset	Protein-Energy Malnutrition
Schizophreniform Disorder	Spinocerebellar Degeneration
Swallowing Disorders	Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Cerebral Degeneration:

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Symptoms & Phenotypes for Cerebral Degeneration

MGI Mouse Phenotypes related to Cerebral Degeneration:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.29	ABCD1 ABCD2 ASPA DLG4 EIF2B5 ERCC6
2	growth/size/body region	MP:0005378	10.23	ASPA DLG4 EIF2B5 EPRS1 ERCC6 GFAP
3	hematopoietic system	MP:0005397	10.18	ABCD1 ABCD2 ASPA DLG4 EIF2B5 ERCC6
4	homeostasis/metabolism	MP:0005376	10.18	ABCD1 ABCD2 ASPA DLG4 EIF2B5 EPRS1
5	immune system	MP:0005387	10.1	ABCD1 ABCD2 DLG4 EIF2B5 ERCC6 GFAP
6	mortality/aging	MP:0010768	10.07	ABCD1 ASPA DLG4 EIF2B5 EPRS1 ERCC6
7	nervous system	MP:0003631	10	ABCD1 ABCD2 ASPA DLG4 EIF2B5 ERCC6
8	hearing/vestibular/ear	MP:0005377	9.91	ASPA ERCC6 NOTCH3 PLP1 POLG ZIC3
9	skeleton	MP:0005390	9.65	ASPA DLG4 EPRS1 ERCC6 NOTCH3 PLA2G6
10	vision/eye	MP:0005391	9.32	ABCD1 ASPA EIF2B5 ERCC6 GFAP GJC2

Sources

Drugs & Therapeutics for Cerebral Degeneration

Drugs for Cerebral Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Galantamine

Approved

Phase 3

357-70-0

9651

Synonyms:

(-)-Galanthamine

(-)-GALANTHAMINE

(4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro(3a,3,2-ef)(2)benzazepin-6-ol

1551-02-6

1953-04-4

1dx6

1qti

357-70-0

4-27-00-02184 (Beilstein Handbook Reference)

736-79-8

AC1L1TIM

AC-20240

BIDD:GT0517

BPBio1_000480

BRD-K49481516-004-03-5

BRD-K49481516-004-04-3

BRN 0093736

BSPBio_000436

BSPBio_003416

C08526

CHEBI:42944

CHEMBL659

CID9651

D04292

DivK1c_000590

Galantamin

Galantamina

Galantamina [INN-Spanish]

Galantamine

Galantamine (USAN/INN)

Galantamine [USAN:INN]

Galantaminum

Galantaminum [INN-Latin]

galanthamine

Galanthamine

Galanthamine hydrobromide

Galanthaminum

GNT

HMS2089H03

HSDB 7361

IDI1_000590

InChI=1/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1

Jilkon

KBio1_000590

KBio2_001751

KBio2_004319

KBio2_006887

KBio3_002636

KBioGR_001417

KBioSS_001751

LS-71039

Lycoremin

Lycoremine

MolPort-002-521-885

NCGC00024731-02

NINDS_000590

Nivalin

Nivaline

NSC 100058

ortho McNeil neurologics brand OF galantamine

ortho-McNeil neurologics brand OF galantamine

Prestwick0_000588

Prestwick1_000588

Prestwick2_000588

Prestwick3_000588

Probes1_000055

Probes2_000395

Razadyne

Razadyne ER

Reminyl

Reminyl (TN)

SDCCGMLS-0066737.P001

SMP1_000131

SPBio_002655

Spectrum_001271

Spectrum3_001738

Spectrum4_000839

Spectrum5_001673

STOCK1N-46108

UNII-0D3Q044KCA

Neurotransmitter Agents

Phase 3

Nootropic Agents

Phase 3

Autonomic Agents

Phase 3

Cholinergic Agents

Phase 3

Cholinesterase Inhibitors

Phase 3

Montelukast

Approved

Phase 2

158966-92-8

5281040

Synonyms:

(R-(e))-1-(((1-(3-(2-(7-chloro-2-Quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetate

(R-(e))-1-(((1-(3-(2-(7-chloro-2-Quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid

(R-(E))-1-(((1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid

{1-[({(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl}sulfanyl)methyl]cyclopropyl}acetic acid

1-((((1R)-1-(3-((1E)-2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid

1-[[[(1 R)-1-[3-[(1E)-2-(7-chloro-2-Quinolinyl)ethenyl] phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetate

1-[[[(1 R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl] phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid

1-[[[(1 R)-1-[3-[(1E)-2-(7-chloro-2-Quinolinyl)ethenyl] phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid

1-[[[(1 R)-1-[3-[(1E)-2-(7-chloro-2-Quinolinyl)ethenyl] phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulphanyl]methyl]cyclopropaneacetate

1-[[[(1 R)-1-[3-[(1E)-2-(7-chloro-2-Quinolinyl)ethenyl] phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulphanyl]methyl]cyclopropaneacetic acid

151767-02-1 (sodium)

158966-92-8

2-[1-[[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid

AC1NQXXW

Apxi toxin

BIDD:GT0394

Brondilat

Brondilat (TN)

C07482

C35H36ClNO3S

Cahill may roberts brand OF montelukast sodium

CHEBI:50730

CHEMBL787

CID5281040

D08229

DB00471

HMS2089D07

HSDB 7582

LS-173539

Merck brand OF montelukast sodium

Merck frosst brand OF montelukast sodium

Merck sharp and dohme brand OF montelukast sodium

MK 0476

MK-0476

Montair

montelukast

Montelukast

Montélukast

Montelukast (INN)

Montelukast [INN:BAN]

Montelukast sodium

Montelukastum

Singulair

Singular

sodium 1-(((1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropylacetate

Sodium 1-(((1-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropylacetate

UNII-MHM278SD3E

Respiratory System Agents

Phase 2

Anti-Asthmatic Agents

Phase 2

Hormone Antagonists

Phase 2

Leukotriene Antagonists

Phase 2

Hormones

Phase 2

Triamcinolone

Approved, Vet_approved

124-94-7

31307

Synonyms:

(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione

11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione

11b,16a,17a,21-Tetrahydroxy-9a-fluoro-1,4-pregnadiene-3,20-dione

11beta,16alpha,17alpha,21-Tetrahydroxy-9alpha-fluoro-1,4-pregnadiene-3,20-dione

11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione

11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione

124-94-7

4-08-00-03629 (Beilstein Handbook Reference)

83474-03-7

9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy

9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione

9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d

9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione

9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone

9a-fluoro-11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9a-fluoro-11b,16a,17a,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9a-fluoro-16a-Hydroxyprednisolone

9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione

9alpha-fluoro-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9alpha-fluoro-11beta,16alpha,17alpha,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9alpha-fluoro-16alpha-Hydroxyprednisolone

9alpha-Fluoro-16alpha-hydroxyprednisolone

9-alpha-Fluoro-16-alpha-hydroxyprednisolone

9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9-fluoro-11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9-fluoro-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione

9α-fluoro-16α-hydroxyprednisolone

AC1L1LDH

AC1Q5HJC

AC-2072

Adcortyl

Aristocort

Aristocort A

Aristocort Tablets

Aristogel

Aristospan

Azmacort

Bio-0662

BPBio1_000154

BRD-K77554836-001-03-3

BRN 2341955

BSPBio_000140

C21H27FO6

Celeste

CHEMBL1451

CID31307

Cinolone

Cinolone-T

CL 19823

D00385

D014221

DB00620

Delphicort

droxypregna-1,4-diene-3,20-dione

EINECS 204-718-7

EU-0101179

Fluoxiprednisolone

Fluoxyprednisolone

Flutex

Fougera

HMS1568G22

HMS2090D12

HSDB 3194

ione

Kenacort

Kenacort (TN)

Kenacort-A

Kenacort-Ag

Kenacort-AG

Kenalog

Kenalog in Orabase

Kenalog-10

Kenalog-40

Kenalog-H

Ledercort

Lopac0_001179

LS-698

MLS000028542

MLS001066543

MLS002695935

MolPort-002-528-981

Mycolog

Nasacort

Nasacort Aq

Nasacort Hfa

NCGC00021580-03

NCGC00021580-04

NCGC00021580-05

NCGC00021580-06

NCGC00021580-07

nchembio.2007.53-comp7

NCI60_000750

NSC 13397

NSC13397

Omcilon

Omicilon

Oracort

Oralone

Orion

Polcortolon

Pregna-1,4-diene-3,20-dio

Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)

Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)

Prestwick_438

Prestwick0_000120

Prestwick1_000120

Prestwick2_000120

Prestwick3_000120

Rodinolone

S1933_Selleck

Sk-Triamcinolone

SK-Triamcinolone

SMP1_000300

SMR000058333

SPBio_002079

T6376_SIGMA

Tiamcinolonum

Tiamcinolonum [INN-Latin]

Triacet

Triacort

Triamcet

Triamcinalone

Triamcinlon

Triamcinolon

Triamcinolona

Triamcinolona [INN-Spanish]

triamcinolone

Triamcinolone

Triamcinolone (JP15/USP/INN)

TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))

Triamcinolone [USAN:INN:BAN:JAN]

Triamcinolone acetonide

Triamcinolone diacetate

Triamcinolone hexacetonide

Triamcinolonum

Triamcinolonum [INN]

Triam-Tablinen

Triatex

Tricortale

Triderm

Trilone

Tri-Nasal

Tristoject

Trymex

UNII-1ZK20VI6TY

Vetalog

Volon

Volon A

WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ

ZINC03882036

Triamcinolone diacetate

Triamcinolone hexacetonide

triamcinolone acetonide

Fluorodeoxyglucose F18

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A European Multi-Center Study to Determine the Safety and Efficacy of Galanthamine Hydrobromide 40mg/Day (32 mg /Day GAL Base, Tid Dose Regimen) in Patients Diagnosed With Alzheimer-Type Dementia	Completed	NCT00338117	Phase 3	Galantamine hydrobromide
2	Effects of Montelukast Therapy on Alzheimer's Disease (EMERALD)	Recruiting	NCT03991988	Phase 2	Montelukast;Placebo oral tablet
3	Magnetic Resonance Imaging Biomarkers in Amyotrophic Lateral Sclerosis	Completed	NCT02405182
4	The Motor Network in Essential Tremor: Mechanisms of Therapy	Recruiting	NCT02712515
5	Closing the Loop on Tremor: A Responsive Deep Brain Stimulator for the Treatment of Essential Tremor	Recruiting	NCT02649166
6	Application of Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance	Recruiting	NCT03112902
7	Novel MRI Biomarkers for Monitoring Disease Progression in ALS	Recruiting	NCT03362658
8	Coaching for Cognition in Alzheimer's (COCOA)	Recruiting	NCT03424200
9	Benefit of MRI and 18F-FDG PET Imaging in the Early Diagnosis of Alzheimer-like Dementia	Terminated	NCT01815112
10	Treating Sleep Wake Cycle Disturbances in Basal Ganglia Neurodegenerative Disorder Subjects With Ramelteon- A Double Blind, Placebo Controlled Trial	Withdrawn	NCT00907595		Ramelteon;Placebo

Search NIH Clinical Center for Cerebral Degeneration

Sources

Genetic Tests for Cerebral Degeneration

Sources

Anatomical Context for Cerebral Degeneration

MalaCards organs/tissues related to Cerebral Degeneration:

⁴⁰

Brain, Liver, Cortex, Skin, Testes, Amygdala, Breast

Sources

Publications for Cerebral Degeneration

Articles related to Cerebral Degeneration:

(show top 50) (show all 180)

#	Title	Authors	PMID	Year
1	Cerebral degeneration in amyotrophic lateral sclerosis: A prospective multicenter magnetic resonance spectroscopy study. ⁶¹	Srivastava O...Kalra S	31750025	2019
2	Quantifying changes on susceptibility weighted images in amyotrophic lateral sclerosis using MRI texture analysis. ⁶¹	Johns SLM...Kalra S	31025885	2019
3	Reliability of 3D texture analysis: A multicenter MRI study of the brain. ⁶¹	Ta D...Kalra S	31423714	2019
4	Leukoencephalopathy, Intracranial Calcifications, Cysts, and SNORD118 Mutation (Labrune Syndrome) with Obstructive Hydrocephalus. ⁶¹	Shtaya A...Hettige S	30794980	2019
5	Management of concussion in soccer. ⁶¹	Hubertus V...Vajkoczy P	30687899	2019
6	Alabama Brief Cognitive Screener: Utility of a New Cognitive Screening Instrument in a Memory Disorders Clinic. ⁶¹	Love MCN...Geldmacher DS	30896091	2019
7	Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects of PF-06751979, a Potent and Selective Oral BACE1 Inhibitor: Results from Phase I Studies in Healthy Adults and Healthy Older Subjects. ⁶¹	Qiu R...Chen D	31424395	2019
8	Antioxidant Defense, Redox Homeostasis, and Oxidative Damage in Children With Ataxia Telangiectasia and Nijmegen Breakage Syndrome. ⁶¹	Maciejczyk M...Mikoluc B	31611883	2019
9	A study of the effects of 8-week acupuncture treatment on patients with Parkinson's disease. ⁶¹	Yeo S...Lim S	30557997	2018
10	Evaluating the cerebral correlates of survival in amyotrophic lateral sclerosis. ⁶¹	Ishaque A...Kalra S	30480029	2018
11	Texture Analysis to Detect Cerebral Degeneration in Amyotrophic Lateral Sclerosis. ⁶¹	Ishaque A...Kalra S	30234470	2018
12	The role of Alu-derived RNAs in Alzheimer's and other neurodegenerative conditions. ⁶¹	Polesskaya O...Myakishev-Rempel M	29685192	2018
13	Interaction between the AAA ATPase p97/VCP and a concealed UBX domain in the copper transporter ATP7A is associated with motor neuron degeneration. ⁶¹	Yi L...Kaler SG	29599289	2018
14	A strategy to find novel candidate anti-Alzheimer's disease drugs by constructing interaction networks between drug targets and natural compounds in medical plants. ⁶¹	Chen BW...Huang JF	29770277	2018
15	Type-I interferons in Parkinson's disease: innate inflammatory response drives fate of neurons in model of degenerative brain disorder: An editorial comment on 'Type-I interferons mediate the neuroinflammatory response and neurotoxicity induced by rotenone'. ⁶¹	Kanninen KM...White AR	28332229	2017
16	Widespread temporo-occipital lobe dysfunction in amyotrophic lateral sclerosis. ⁶¹	Loewe K...Schoenfeld MA	28067298	2017
17	Abnormal Brain Connectivity Spectrum Disorders Following Thimerosal Administration: A Prospective Longitudinal Case-Control Assessment of Medical Records in the Vaccine Safety Datalink. ⁶¹	Geier DA...Geier MR	28539852	2017
18	Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication Stage V). ⁶¹	Hayashi K...Isozaki E	27716404	2016
19	Dispersion entropy for the analysis of resting-state MEG regularity in Alzheimer's disease. ⁶¹	Azami H...Escudero J	28269715	2016
20	Crosstalk between 6-OHDA-induced autophagy and apoptosis in PC12 cells is mediated by phosphorylation of Raf-1/ERK1/2. ⁶¹	Li J...Wu B	29442034	2016
21	Split Hand / Foot Malformation Syndrome with Cerebral Degeneration. ⁶¹	Mahavar SK...Sharma R	27730782	2016
22	High Content, Multi-Parameter Analyses in Buccal Cells to Identify Alzheimer's Disease. ⁶¹	Francois M...The Australian Imaging Biomarkers And Lifestyle Study Research Group	26975368	2016
23	Cerebral Degeneration in Amyotrophic Lateral Sclerosis Revealed by 3-Dimensional Texture Analysis. ⁶¹	Maani R...Kalra S	27064416	2016
24	Thimerosal exposure and increased risk for diagnosed tic disorder in the United States: a case-control study. ⁶¹	Geier DA...Geier MR	27486363	2015
25	Early detection of widespread progressive brain injury after cardiac arrest: a single case DTI and post-mortem histology study. ⁶¹	Gerdes JS...Deppe M	24633135	2014
26	[Genetic aspects of Alzheimer's disease (Review)]. ⁶¹	El Kadmiri N...Nadifi S	24035416	2013
27	Improved prediction of Alzheimer's disease with longitudinal white matter/gray matter contrast changes. ⁶¹	Grydeland H...Fjell AM	22674625	2013
28	Specific needs of dopamine neurons for stimulation in order to survive: implication for Parkinson disease. ⁶¹	Michel PP...Hirsch EC	23699175	2013
29	Mentalizing in preclinical Huntington's disease: an fMRI study using cartoon picture stories. ⁶¹	Saft C...Brune M	23179063	2013
30	Mitochondrial aldehyde dehydrogenase-2 activation prevents β-amyloid-induced endothelial cell dysfunction and restores angiogenesis. ⁶¹	Solito R...Donnini S	23447675	2013
31	Phenotypic spectrum of COL4A1 mutations: porencephaly to schizencephaly. ⁶¹	Yoneda Y...Saitsu H	23225343	2013
32	The response of cerebral cortex to haemorrhagic damage: experimental evidence from a penetrating injury model. ⁶¹	Purushothuman S...Stone J	23555765	2013
33	Disease-specific expression of the serotonin-receptor 5-HT(2C) in natural killer cells in Alzheimer's dementia. ⁶¹	Martins LC...Reis HJ	22766135	2012
34	Acupuncture stimulation on GB34 activates neural responses associated with Parkinson's disease. ⁶¹	Yeo S...Kim SH	22943145	2012
35	Fractional anisotropy of water diffusion in cerebral white matter across the lifespan. ⁶¹	Kochunov P...Glahn DC	20122755	2012
36	De novo and inherited mutations in COL4A2, encoding the type IV collagen α2 chain cause porencephaly. ⁶¹	Yoneda Y...Saitsu H	22209246	2012
37	Intranasal treatment of neurodegenerative diseases and stroke. ⁶¹	Gomez D...Toth CC	22202044	2012
38	Transient improvement of acquired hepatocerebral degeneration with parkinsonian symptoms after failed liver transplant: case report and literature review. ⁶¹	Chen Y...Yoshida EM	22142042	2011
39	The multiple phenotypes of corticobasal syndrome and corticobasal degeneration: implications for further study. ⁶¹	Boeve BF	21853287	2011
40	Association between environmental exposure to pesticides and neurodegenerative diseases. ⁶¹	Parron T...Alarcon R	21601587	2011
41	The extrinsic and intrinsic apoptotic pathways are involved in manganese toxicity in rat astrocytoma C6 cells. ⁶¹	Alaimo A...Kotler ML	21704098	2011
42	Punica granatum protects against oxidative stress in PC12 cells and oxidative stress-induced Alzheimer's symptoms in mice. ⁶¹	Choi SJ...Shin DH	21631359	2011
43	Visual signs and symptoms of progressive supranuclear palsy. ⁶¹	Armstrong RA	20629667	2011
44	"Theory of mind" is impaired in Huntington's disease. ⁶¹	Brune M...Saft C	21384426	2011
45	Impulsive behavior and associated clinical variables in Parkinson's disease. ⁶¹	Abosch A...Grant JE	21300194	2011
46	Xanthene food dye, as a modulator of Alzheimer's disease amyloid-beta peptide aggregation and the associated impaired neuronal cell function. ⁶¹	Wong HE...Kwon I	21998691	2011
47	Progression of brain atrophy and cognitive decline in diabetes mellitus: a 3-year follow-up. ⁶¹	van Elderen SG...van der Grond J	20837967	2010
48	Proteomic analysis of aging brain in SAMP10 mouse: a model of age-related cerebral degeneration. ⁶¹	Furukawa A...Shimada A	20471994	2010
49	Amygdala size reduction is associated with memory deficits in complicated hereditary spastic paraparesis: an MRI study. ⁶¹	Pinkhardt EH...Kassubek J	20664204	2010
50	The role of stress and anxiety in the onset of familial Creutzfeldt-Jakob Disease (CJD): review. ⁶¹	Gigi A	19051123	2009

Sources

Genes for Cerebral Degeneration

Genes related to Cerebral Degeneration (0 elite genes):

(show top 50) (show all 72)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	DLG4	Discs Large MAGUK Scaffold Protein 4	Protein Coding	11.62	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	SERPINA3	Serpin Family A Member 3	Protein Coding	10.66	DISEASES inferred ¹⁵ ¹⁵
3	ERCC6	ERCC Excision Repair 6, Chromatin Remodeling Factor	Protein Coding	9.55	DISEASES inferred ¹⁵ ¹⁵
4	NOTCH3	Notch Receptor 3	Protein Coding	9.24	DISEASES inferred ¹⁵
5	EPRS1	Glutamyl-Prolyl-TRNA Synthetase 1	Protein Coding	8.93	DISEASES inferred ¹⁵ ¹⁵
6	ABCD1	ATP Binding Cassette Subfamily D Member 1	Protein Coding	8.81	DISEASES inferred ¹⁵
7	PLP1	Proteolipid Protein 1	Protein Coding	8.62	DISEASES inferred ¹⁵
8	CRYAA	Crystallin Alpha A	Protein Coding	8.6	DISEASES inferred ¹⁵ ¹⁵
9	ASPA	Aspartoacylase	Protein Coding	8.15	DISEASES inferred ¹⁵
10	HCG15	HLA Complex Group 15	RNA Gene	7.98	DISEASES inferred ¹⁵ ¹⁵
11	GFAP	Glial Fibrillary Acidic Protein	Protein Coding	7.72	DISEASES inferred ¹⁵
12	H2AC18	H2A Clustered Histone 18	Protein Coding	7.67	DISEASES inferred ¹⁵ ¹⁵
13	POLG	DNA Polymerase Gamma, Catalytic Subunit	Protein Coding	7.67	DISEASES inferred ¹⁵
14	SLC25A17	Solute Carrier Family 25 Member 17	Protein Coding	7.6	DISEASES inferred ¹⁵
15	PLA2G6	Phospholipase A2 Group VI	Protein Coding	7.57	DISEASES inferred ¹⁵
16	PRODH	Proline Dehydrogenase 1	Protein Coding	7.57	DISEASES inferred ¹⁵ ¹⁵
17	ABCD2	ATP Binding Cassette Subfamily D Member 2	Protein Coding	7.51	DISEASES inferred ¹⁵
18	EIF2B5	Eukaryotic Translation Initiation Factor 2B Subunit Epsilon	Protein Coding	7.42	DISEASES inferred ¹⁵
19	ZIC3	Zic Family Member 3	Protein Coding	7.41	DISEASES inferred ¹⁵
20	GJC2	Gap Junction Protein Gamma 2	Protein Coding	7.4	DISEASES inferred ¹⁵
21	HTRA1	HtrA Serine Peptidase 1	Protein Coding	7.27	DISEASES inferred ¹⁵
22	HEPACAM	Hepatic And Glial Cell Adhesion Molecule	Protein Coding	7.25	DISEASES inferred ¹⁵
23	ABCD3	ATP Binding Cassette Subfamily D Member 3	Protein Coding	7.24	DISEASES inferred ¹⁵
24	POLR3B	RNA Polymerase III Subunit B	Protein Coding	7.19	DISEASES inferred ¹⁵
25	L1CAM	L1 Cell Adhesion Molecule	Protein Coding	7.18	DISEASES inferred ¹⁵
26	MBP	Myelin Basic Protein	Protein Coding	7.15	DISEASES inferred ¹⁵
27	EIF2B2	Eukaryotic Translation Initiation Factor 2B Subunit Beta	Protein Coding	7.15	DISEASES inferred ¹⁵
28	AQP4	Aquaporin 4	Protein Coding	7.14	DISEASES inferred ¹⁵
29	LMNB1	Lamin B1	Protein Coding	7.14	DISEASES inferred ¹⁵
30	EIF2B1	Eukaryotic Translation Initiation Factor 2B Subunit Alpha	Protein Coding	7.13	DISEASES inferred ¹⁵
31	FA2H	Fatty Acid 2-Hydroxylase	Protein Coding	7.05	DISEASES inferred ¹⁵
32	HYDIN	HYDIN Axonemal Central Pair Apparatus Protein	Protein Coding	7.03	DISEASES inferred ¹⁵
33	POLR3A	RNA Polymerase III Subunit A	Protein Coding	6.98	DISEASES inferred ¹⁵
34	PRDM10	PR/SET Domain 10	Protein Coding	6.97	DISEASES inferred ¹⁵
35	ALB	Albumin	Protein Coding	6.95	DISEASES inferred ¹⁵
36	NOTCH1	Notch Receptor 1	Protein Coding	6.94	DISEASES inferred ¹⁵
37	TREX1	Three Prime Repair Exonuclease 1	Protein Coding	6.93	DISEASES inferred ¹⁵
38	APP	Amyloid Beta Precursor Protein	Protein Coding	6.88	DISEASES inferred ¹⁵
39	OLIG2	Oligodendrocyte Transcription Factor 2	Protein Coding	6.88	DISEASES inferred ¹⁵
40	GAPDH	Glyceraldehyde-3-Phosphate Dehydrogenase	Protein Coding	6.84	DISEASES inferred ¹⁵
41	APOE	Apolipoprotein E	Protein Coding	6.84	DISEASES inferred ¹⁵
42	NES	Nestin	Protein Coding	6.84	DISEASES inferred ¹⁵
43	FOXJ1	Forkhead Box J1	Protein Coding	6.8	DISEASES inferred ¹⁵
44	GALC	Galactosylceramidase	Protein Coding	6.8	DISEASES inferred ¹⁵
45	MYCBP2	MYC Binding Protein 2	Protein Coding	6.77	DISEASES inferred ¹⁵
46	ABCD4	ATP Binding Cassette Subfamily D Member 4	Protein Coding	6.73	DISEASES inferred ¹⁵
47	PANK2	Pantothenate Kinase 2	Protein Coding	6.73	DISEASES inferred ¹⁵
48	STXBP1	Syntaxin Binding Protein 1	Protein Coding	6.72	DISEASES inferred ¹⁵
49	EIF2B4	Eukaryotic Translation Initiation Factor 2B Subunit Delta	Protein Coding	6.68	DISEASES inferred ¹⁵
50	SOX10	SRY-Box Transcription Factor 10	Protein Coding	6.68	DISEASES inferred ¹⁵

Sources

Variations for Cerebral Degeneration

Sources

Expression for Cerebral Degeneration

Search GEO for disease gene expression data for Cerebral Degeneration.

Sources

Pathways for Cerebral Degeneration

Pathways related to Cerebral Degeneration according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Peroxisome ³⁶	10.72	SLC25A17 ABCD2 ABCD1

Sources

GO Terms for Cerebral Degeneration

Cellular components related to Cerebral Degeneration according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of peroxisomal membrane	GO:0005779	8.96	SLC25A17 ABCD1
2	peroxisomal membrane	GO:0005778	8.8	SLC25A17 ABCD2 ABCD1

Biological processes related to Cerebral Degeneration according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of reactive oxygen species biosynthetic process	GO:1903427	9.46	ABCD2 ABCD1
2	central nervous system myelination	GO:0022010	9.43	PLP1 ASPA
3	neuron projection maintenance	GO:1990535	9.4	ABCD2 ABCD1
4	positive regulation of fatty acid beta-oxidation	GO:0032000	9.37	ABCD2 ABCD1
5	fatty acid beta-oxidation	GO:0006635	9.33	SLC25A17 ABCD2 ABCD1
6	myelin maintenance	GO:0043217	9.32	ABCD2 ABCD1
7	very long-chain fatty acid catabolic process	GO:0042760	9.26	ABCD2 ABCD1
8	positive regulation of unsaturated fatty acid biosynthetic process	GO:2001280	8.96	ABCD2 ABCD1
9	astrocyte development	GO:0014002	8.8	PLP1 GFAP EIF2B5

Sources

Sources for Cerebral Degeneration

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia