MCID: CRB033
MIFTS: 39

Cerebral Degeneration

Categories: Neuronal diseases
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Aliases & Classifications for Cerebral Degeneration

MalaCards integrated aliases for Cerebral Degeneration:

Name: Cerebral Degeneration 11 14 75
Degenerative Brain Disorder 71
Brain Degeneration 11

Classifications:



External Ids:

Disease Ontology 11 DOID:1443
ICD9CM 34 331.9
SNOMED-CT 68 52522001
UMLS 71 C0154671

Summaries for Cerebral Degeneration

Disease Ontology: 11 A brain disease that is characterized by loss of structure or function of neurons, including death of neurons and loss of brain tissue.

MalaCards based summary: Cerebral Degeneration, also known as degenerative brain disorder, is related to hydrocephalus and leukodystrophy. An important gene associated with Cerebral Degeneration is CFAP47 (Cilia And Flagella Associated Protein 47), and among its related pathways/superpathways is Spinal cord injury. The drugs Glucagon and Hormones have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and endothelial, and related phenotypes are nervous system and behavior/neurological

Related Diseases for Cerebral Degeneration

Diseases related to Cerebral Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 183)
# Related Disease Score Top Affiliating Genes
1 hydrocephalus 32.1 SERPINA3 GFAP CFAP47 AQP4
2 leukodystrophy 31.7 SLC25A17 POLR3B POLR3A PLP1 NOTCH3 HEPACAM
3 amyotrophic lateral sclerosis 1 30.7 SERPINA3 GFAP ERCC6 EPRS1 CRYAA AQP4
4 hereditary ataxia 30.4 ERCC6 EPRS1 CRYAA
5 spinal cord disease 30.2 SERPINA3 GFAP AQP4
6 optic nerve disease 30.2 SERPINA3 GFAP ERCC6 EPRS1 CRYAA AQP4
7 alzheimer disease, familial, 1 30.2 SERPINA3 PLP1 PLA2G6 NOTCH3 GFAP CRYAA
8 myopathy 30.1 SERPINA3 PLA2G6 NOTCH3 ERCC6 EPRS1 CRYAA
9 mitochondrial dna depletion syndrome 4a 11.1
10 norrie disease 11.1
11 brain small vessel disease 2 11.1
12 niemann-pick disease 11.0
13 brain small vessel disease 1 with or without ocular anomalies 10.9
14 leukoencephalopathy, brain calcifications, and cysts 10.9
15 lipid storage disease 10.9
16 cerebrotendinous xanthomatosis 10.9
17 phacogenic glaucoma 10.5 SERPINA3 ERCC6 CRYAA
18 pelizaeus-merzbacher-like disease 10.5 PLP1 GJC2
19 cerebrooculofacioskeletal syndrome 2 10.5 POLR3B POLR3A ERCC6
20 binswanger's disease 10.5 NOTCH3 GFAP
21 childhood ataxia with central nervous system hypomyelination / vanishing white matter 10.5 EIF2B5 EIF2B1
22 polr3-related leukodystrophy 10.5 POLR3B POLR3A
23 leukodystrophy, hypomyelinating, 2 10.5 PLP1 GJC2 ASPA
24 leukodystrophy, hypomyelinating, 3 10.5 POLR3A PLP1 GJC2
25 degeneration of macula and posterior pole 10.5 SERPINA3 ERCC6 CRYAA
26 auditory system disease 10.5 ERCC6 EPRS1 CFAP47
27 normal pressure hydrocephalus 10.5 SERPINA3 ERCC6 CFAP47 AQP4
28 primary progressive multiple sclerosis 10.5 SERPINA3 PLP1 AQP4
29 ocular motility disease 10.5 ERCC6 CRYAA AQP4
30 refractive error 10.5 ERCC6 EPRS1 CRYAA
31 gordon holmes syndrome 10.5 POLR3B POLR3A PLA2G6
32 chromosomal disease 10.5 SERPINA3 ERCC6 EPRS1 CRYAA
33 cerebellar disease 10.5 SERPINA3 ERCC6 EPRS1 CRYAA
34 lens disease 10.5 SERPINA3 ERCC6 CRYAA B3GNT2
35 leukodystrophy, hypomyelinating, 4 10.5 POLR3A PLP1 GJC2 CRYAA
36 uveal disease 10.5 SERPINA3 ERCC6 CRYAA
37 hypomyelinating leukoencephalopathy 10.5 POLR3B POLR3A PLP1 GJC2
38 leukodystrophy, hypomyelinating, 9 10.5 POLR3B POLR3A GJC2 ERCC6
39 spasticity 10.5 POLR3A PLP1 GFAP
40 balo concentric sclerosis 10.5 GJC2 AQP4
41 sensory system disease 10.5 SERPINA3 ERCC6 EPRS1 CRYAA CFAP47
42 leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism 10.5 POLR3B POLR3A PLP1 GJC2
43 disease of mental health 10.5 SERPINA3 GFAP ERCC6 EPRS1
44 corneal disease 10.5 SERPINA3 ERCC6 CRYAA
45 optic neuritis 10.5 PLP1 GFAP AQP4
46 bile acid synthesis defect, congenital, 5 10.5 SLC25A17 ABCD1
47 arachnoiditis 10.5 GFAP AQP4
48 muscle tissue disease 10.5 SERPINA3 ERCC6 EPRS1 CRYAA B3GNT2
49 neuroma 10.5 SERPINA3 GFAP AQP4
50 communicating hydrocephalus 10.5 SERPINA3 ERCC6 CFAP47 B3GNT2 AQP4

Comorbidity relations with Cerebral Degeneration via Phenotypic Disease Network (PDN): (show all 23)


Acute Cystitis Alzheimer Disease, Familial, 1
Bronchitis Cerebral Atherosclerosis
Cerebrovascular Disease Decubitus Ulcer
Deficiency Anemia Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Impaired Intellectual Development Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hypothyroidism
Iron Deficiency Anemia Major Depressive Disorder
Obstructive Hydrocephalus Osteoporosis
Parkinson Disease, Late-Onset Protein-Energy Malnutrition
Schizophreniform Disorder Swallowing Disorders
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Cerebral Degeneration:



Diseases related to Cerebral Degeneration

Symptoms & Phenotypes for Cerebral Degeneration

GenomeRNAi Phenotypes related to Cerebral Degeneration according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.13 ABCD1 AQP4 ASPA B3GNT2 CFAP47 CRYAA
2 no effect GR00402-S-2 10.13 AQP4 ASPA B3GNT2 CFAP47 EIF2B1 ERCC6

MGI Mouse Phenotypes related to Cerebral Degeneration:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.22 ABCD1 AQP4 ASPA B3GNT2 EIF2B5 ERCC6
2 behavior/neurological MP:0005386 10.13 ABCD1 AQP4 ASPA B3GNT2 EIF2B5 ERCC6
3 cellular MP:0005384 10.11 B3GNT2 CFAP47 CRYAA EPRS1 ERCC6 GFAP
4 immune system MP:0005387 10.07 ABCD1 AQP4 B3GNT2 EIF2B5 ERCC6 GFAP
5 vision/eye MP:0005391 9.9 ABCD1 AQP4 ASPA CRYAA EIF2B5 ERCC6
6 hematopoietic system MP:0005397 9.77 ABCD1 AQP4 ASPA B3GNT2 EIF2B5 ERCC6
7 mortality/aging MP:0010768 9.47 ABCD1 AQP4 ASPA EIF2B5 EPRS1 ERCC6

Drugs & Therapeutics for Cerebral Degeneration

Drugs for Cerebral Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glucagon Approved 16941-32-5 16133228 16186314
2 Hormones
3 Hormone Antagonists
4 Glucagon-Like Peptide 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect of Glucagon-like Peptide-1 (GLP-1) on Cognitive and Non-cognitive Function in Human Completed NCT03414333 GLP-1

Search NIH Clinical Center for Cerebral Degeneration

Genetic Tests for Cerebral Degeneration

Anatomical Context for Cerebral Degeneration

Organs/tissues related to Cerebral Degeneration:

MalaCards : Brain, Temporal Lobe, Endothelial, Fetal Brain, Prefrontal Cortex, Skeletal Muscle, Occipital Lobe

Publications for Cerebral Degeneration

Articles related to Cerebral Degeneration:

(show top 50) (show all 501)
# Title Authors PMID Year
1
Audiological Findings in Children with PLA2G6-Associated Neurodegeneration. 62
35705187 2022
2
Electroencephalographic hallmarks of Alzheimer's disease. 62
36055410 2022
3
Propagation of Parkinson's disease by extracellular vesicle production and secretion. 62
36111783 2022
4
The Natural Neuroprotective Compounds Used in the 6-Hydroxydopamine-Induced Parkinson's Disease in Zebrafish: The Current Applications and Perspectives. 62
36306449 2022
5
My experience of living with nonfluent/agrammatic variant primary progressive aphasia: Challenges, compensatory strategies and adaptations. 62
36239167 2022
6
Crossed functional specialization between the basal ganglia and cerebellum during vocal emotion decoding: Insights from stroke and Parkinson's disease. 62
35474566 2022
7
Wilson disease diagnosed incidentally by targeted gene panel sequencing in a Korean boy with severe obesity. 62
34670068 2022
8
Huperzine aggravated neurochemical and volumetric changes induced by D-galactose in the model of neurodegeneration in rats. 62
35636645 2022
9
Microwave Radiation and the Brain: Mechanisms, Current Status, and Future Prospects. 62
36012552 2022
10
Extended anesthesia exposure for abdominal and pelvic procedures in older adults with colorectal cancer: Associations with chart dementia diagnoses. 62
35525395 2022
11
Effects of Alexander disease-associated mutations on the assembly and organization of GFAP intermediate filaments. 62
35511821 2022
12
Tissue-specific toxicity of clothianidin on rainbow trout (Oncorhynchus mykiss). 62
33641563 2022
13
Aberrant topological organization and age-related differences in the human connectome in subjective cognitive decline by using regional morphology from magnetic resonance imaging. 62
35579698 2022
14
Identification of novel and potential PPARγ stimulators as repurposed drugs for MCAO associated brain degeneration. 62
35550883 2022
15
D-galactose-induced aging in rats - The effect of metformin on bioenergetics of brain, skeletal muscle and liver. 62
35314269 2022
16
Kaempferol prevents the activation of complement C3 protein and the generation of reactive A1 astrocytes that mediate rat brain degeneration induced by 3-nitropropionic acid. 62
35452770 2022
17
A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer's disease. 62
35585302 2022
18
Dietary Soy Prevents Alcohol-Mediated Neurocognitive Dysfunction and Associated Impairments in Brain Insulin Pathway Signaling in an Adolescent Rat Model. 62
35625605 2022
19
Myeloid cells in retinal and brain degeneration. 62
34478598 2022
20
Distinct patterns of progressive gray and white matter degeneration in amyotrophic lateral sclerosis. 62
34908212 2022
21
Targeting estrogen signaling in the radiation-induced neurodegeneration: possible role of phytoestrogens. 62
35272592 2022
22
Physician Palliative Education Associated With High Use of Hospice Care Service. 62
33960206 2022
23
Magnetic Resonance Imaging and Its Clinical Correlation in Spinocerebellar Ataxia Type 3: A Systematic Review. 62
35757531 2022
24
Hippocampal Mitochondrial Abnormalities Induced the Dendritic Complexity Reduction and Cognitive Decline in a Rat Model of Spinal Cord Injury. 62
35571236 2022
25
The Effect of Multimodal Non-pharmacological Interventions on Cognitive Function Improvement for People With Dementia: A Systematic Review. 62
35903373 2022
26
The mechanism of Girdin in degenerative brain disease caused by high glucose stimulation. 62
36329890 2022
27
Sleep Quality Improvement Enhances Neuropsychological Recovery and Reduces Blood Aβ42/40 Ratio in Patients with Mild-Moderate Cognitive Impairment. 62
34946311 2021
28
Effect of carbon nanomaterial dimension on the functional activity and degeneration of neurons. 62
34739983 2021
29
Transcriptional signatures of synaptic vesicle genes define myotonic dystrophy type I neurodegeneration. 62
33955002 2021
30
Chemotherapy and the Risk of Alzheimer's Disease in Colorectal Cancer Survivors: Evidence From the Medicare System. 62
33630665 2021
31
Grey matter volume abnormalities in the first depressive episode of medication-naïve adult individuals: a systematic review of voxel based morphometric studies. 62
33351672 2021
32
Introducing ADNP and SIRT1 as new partners regulating microtubules and histone methylation. 62
33967268 2021
33
Longitudinal structural brain changes in Friedreich ataxia depend on disease severity: the IMAGE-FRDA study. 62
33860369 2021
34
Neuronal cell-based medicines from pluripotent stem cells: Development, production, and preclinical assessment. 62
34724724 2021
35
Bisphenol a Induces Autophagy Defects and AIF-Dependent Apoptosis via HO-1 and AMPK to Degenerate N2a Neurons. 62
34681608 2021
36
Cerebrospinal fluid may flow out from the brain through the frontal skull base and choroid plexus: a gold colloid and cadaverine injection study in mouse fetus. 62
34282473 2021
37
Structural and functional magnetic resonance imaging in isolated REM sleep behavior disorder: A systematic review of studies using neuroimaging software. 62
33979733 2021
38
Nystagmus may be the first neurological sign in early stages of spinocerebellar ataxia type 3. 62
34706018 2021
39
Progressive Neurochemical Abnormalities in Cognitive and Motor Subgroups of Amyotrophic Lateral Sclerosis: A Prospective Multicenter Study. 62
34426551 2021
40
Quantitative evaluation of brain volumes in drug-free major depressive disorder using MRI-Cloud method. 62
34075004 2021
41
Elevated complement mediator levels in endothelial-derived plasma exosomes implicate endothelial innate inflammation in diminished brain function of aging humans. 62
34376699 2021
42
Chronic colitis exacerbates NLRP3-dependent neuroinflammation and cognitive impairment in middle-aged brain. 62
34229722 2021
43
Development of a Palliative Care Approach for Primary Progressive Aphasia: My Experience as a Person Living With This Rare Disorder. 62
34210214 2021
44
Ameliorative effects of the aqueous extract of Khaya anthotheca (Welw.) C.DC (Meliaceae) in vanadium induced anxiety, memory loss and pathologies in the brain and ovary of mice. 62
33831470 2021
45
From Cerebellar Apoplexy in 1849 to Cerebellar Stroke in the 2020s: Robert Dunn's Contribution. 62
33646479 2021
46
Longitudinal Analysis of the Relation Between Clinical Impairment and Gray Matter Degeneration in Spinocerebellar Ataxia Type 7 Patients. 62
33184781 2021
47
High-Sensitivity and Trace-Amount Specimen Electrochemical Sensors for Exploring the Levels of β-Amyloid in Human Blood and Tears. 62
34047190 2021
48
Repetitive mild head trauma induces activity mediated lifelong brain deficits in a novel Drosophila model. 62
33958652 2021
49
The Relevance of Amyloid β-Calmodulin Complexation in Neurons and Brain Degeneration in Alzheimer's Disease. 62
34067061 2021
50
Vitamin D and Folate as Predictors of MMSE in Alzheimer's Disease: A Machine Learning Analysis. 62
34073931 2021

Variations for Cerebral Degeneration

Expression for Cerebral Degeneration

Search GEO for disease gene expression data for Cerebral Degeneration.

Pathways for Cerebral Degeneration

Pathways related to Cerebral Degeneration according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.86 PLA2G6 GFAP AQP4

GO Terms for Cerebral Degeneration

Cellular components related to Cerebral Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 eukaryotic translation initiation factor 2B complex GO:0005851 9.26 EIF2B5 EIF2B1
2 obsolete integral component of peroxisomal membrane GO:0005779 9.16 SLC25A17 ABCD1
3 astrocyte end-foot GO:0097450 8.92 GFAP AQP4

Biological processes related to Cerebral Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to heat GO:0009408 9.63 EIF2B5 EIF2B1 CRYAA
2 positive regulation of calcium ion transmembrane transport GO:1904427 9.26 PLP1 GJC2
3 astrocyte development GO:0014002 9.1 PLP1 GFAP EIF2B5

Sources for Cerebral Degeneration

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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