MCID: CRB033
MIFTS: 42

Cerebral Degeneration

Categories: Neuronal diseases

Aliases & Classifications for Cerebral Degeneration

MalaCards integrated aliases for Cerebral Degeneration:

Name: Cerebral Degeneration 12 15
Degenerative Brain Disorder 71
Brain Degeneration 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1443
ICD9CM 34 331.9
SNOMED-CT 67 52522001
UMLS 71 C0154671

Summaries for Cerebral Degeneration

Disease Ontology : 12 A brain disease that is characterized by loss of structure or function of neurons, including death of neurons and loss of brain tissue.

MalaCards based summary : Cerebral Degeneration, also known as degenerative brain disorder, is related to leukodystrophy and amyotrophic lateral sclerosis 1. An important gene associated with Cerebral Degeneration is DLG4 (Discs Large MAGUK Scaffold Protein 4), and among its related pathways/superpathways is Peroxisome. The drugs Galantamine and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, retina and cortex, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 74 Neurodegeneration is the progressive loss of structure or function of neurons, including death of... more...

Related Diseases for Cerebral Degeneration

Diseases related to Cerebral Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)
# Related Disease Score Top Affiliating Genes
1 leukodystrophy 32.4 SLC25A17 SERPINA3 PLP1 NOTCH3 GJC2 GFAP
2 amyotrophic lateral sclerosis 1 30.9 SERPINA3 PRODH H2AC18 GFAP ERCC6 EPRS1
3 autosomal dominant cerebellar ataxia 30.8 SERPINA3 H2AC18 ERCC6 CRYAA
4 mitochondrial dna depletion syndrome 4a 11.6
5 norrie disease 11.2
6 niemann-pick disease 11.1
7 brain small vessel disease 1 with or without ocular anomalies 11.1
8 brain small vessel disease 2 11.1
9 hydrocephalus 11.1
10 cerebrotendinous xanthomatosis 10.9
11 canavan disease 10.9
12 lipid storage disease 10.9
13 ossifying fibroma 10.8 SERPINA3 NOTCH3 ERCC6
14 binswanger's disease 10.8 PLP1 NOTCH3 GFAP
15 leukodystrophy, hypomyelinating, 5 10.8 PLP1 GJC2 ERCC6
16 fatal familial insomnia 10.8 SERPINA3 PRODH ERCC6
17 arteriolosclerosis 10.8 SERPINA3 NOTCH3 HTRA1
18 vasculopathy, retinal, with cerebral leukodystrophy 10.8 SERPINA3 NOTCH3 HTRA1
19 auditory system disease 10.8 SERPINA3 PRODH ERCC6 EPRS1
20 leukodystrophy, hypomyelinating, 4 10.8 PLP1 GJC2 CRYAA
21 epilepsy, familial temporal lobe, 1 10.8 H2AC18 ERCC6 EPRS1
22 adrenomyeloneuropathy 10.8 SLC25A17 ABCD1
23 fibrillary astrocytoma 10.8 SERPINA3 H2AC18 GFAP
24 robinow syndrome, autosomal recessive 1 10.8 H2AC18 ERCC6 EPRS1
25 cerebellar ataxia type 47 10.8 SERPINA3 ERCC6
26 cranial nerve disease 10.8 SERPINA3 GFAP ERCC6 CRYAA
27 robinow syndrome 10.8 H2AC18 ERCC6 EPRS1
28 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 10.7 SERPINA3 NOTCH3 HTRA1
29 cerebellar disease 10.7 SERPINA3 PRODH H2AC18 ERCC6
30 lens disease 10.7 SERPINA3 H2AC18 ERCC6 CRYAA
31 central nervous system benign neoplasm 10.7 SERPINA3 H2AC18 GFAP
32 alexander disease 10.7 PLP1 GFAP CRYAA
33 toxic encephalopathy 10.7 SERPINA3 H2AC18 GFAP DLG4
34 corneal disease 10.7 SERPINA3 H2AC18 ERCC6 CRYAA
35 acute cystitis 10.7 SERPINA3 H2AC18 EPRS1
36 teeth hard tissue disease 10.7 SERPINA3 H2AC18 ERCC6
37 parasitic protozoa infectious disease 10.7 SERPINA3 PRODH H2AC18 EPRS1
38 carbohydrate metabolic disorder 10.7 PRODH H2AC18 ERCC6 CRYAA
39 optic nerve disease 10.7 SERPINA3 GFAP ERCC6 CRYAA
40 spinal cord disease 10.7 H2AC18 GFAP ABCD1
41 prion disease 10.7 SERPINA3 H2AC18 GFAP CRYAA
42 substance abuse 10.7 SERPINA3 PRODH PLP1 H2AC18
43 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2 10.7 NOTCH3 HTRA1
44 disorders of sexual development 10.7 H2AC18 ERCC6 EPRS1
45 testicular disease 10.7 SERPINA3 H2AC18 ERCC6
46 bone structure disease 10.7 PRODH HTRA1 ERCC6
47 early-onset parkinson's disease 10.7 PRODH PLA2G6 CRYAA
48 amino acid metabolic disorder 10.7 SERPINA3 PRODH H2AC18 EPRS1 CRYAA
49 germ cell and embryonal cancer 10.7 SERPINA3 PRODH H2AC18
50 chromosomal disease 10.7 SERPINA3 PRODH H2AC18 EPRS1 CRYAA

Comorbidity relations with Cerebral Degeneration via Phenotypic Disease Network (PDN): (show all 24)


Acute Cystitis Alzheimer Disease
Bronchitis Cerebral Atherosclerosis
Cerebrovascular Disease Decubitus Ulcer
Deficiency Anemia Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hypothyroidism
Iron Deficiency Anemia Major Depressive Disorder
Obstructive Hydrocephalus Osteoporosis
Parkinson Disease, Late-Onset Protein-Energy Malnutrition
Schizophreniform Disorder Spinocerebellar Degeneration
Swallowing Disorders Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Cerebral Degeneration:



Diseases related to Cerebral Degeneration

Symptoms & Phenotypes for Cerebral Degeneration

MGI Mouse Phenotypes related to Cerebral Degeneration:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.28 ABCD1 ABCD2 ASPA B3GNT2 DLG4 EIF2B5
2 growth/size/body region MP:0005378 10.18 ASPA B3GNT2 DLG4 EIF2B5 EPRS1 ERCC6
3 homeostasis/metabolism MP:0005376 10.13 ABCD1 ABCD2 ASPA DLG4 EIF2B5 EPRS1
4 hematopoietic system MP:0005397 10.11 ABCD1 ABCD2 ASPA B3GNT2 DLG4 EIF2B5
5 immune system MP:0005387 10 ABCD1 ABCD2 B3GNT2 DLG4 EIF2B5 ERCC6
6 nervous system MP:0003631 9.97 ABCD1 ABCD2 ASPA B3GNT2 DLG4 EIF2B5
7 skeleton MP:0005390 9.61 ASPA DLG4 EPRS1 ERCC6 HTRA1 NOTCH3
8 vision/eye MP:0005391 9.32 ABCD1 ASPA EIF2B5 ERCC6 GFAP GJC2

Drugs & Therapeutics for Cerebral Degeneration

Drugs for Cerebral Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Galantamine Approved Phase 3 357-70-0 9651
2 Neurotransmitter Agents Phase 3
3 Cholinesterase Inhibitors Phase 3
4 Cholinergic Agents Phase 3
5
Montelukast Approved Phase 2 158966-92-8 5281040
6 Respiratory System Agents Phase 2
7 Hormone Antagonists Phase 2
8 Hormones Phase 2
9 Leukotriene Antagonists Phase 2
10 Anti-Asthmatic Agents Phase 2
11
Triamcinolone Approved, Vet_approved 124-94-7 31307
12 Triamcinolone hexacetonide
13 Triamcinolone diacetate
14 triamcinolone acetonide
15 Fluorodeoxyglucose F18

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 A European Multi-Center Study to Determine the Safety and Efficacy of Galanthamine Hydrobromide 40mg/Day (32 mg /Day GAL Base, Tid Dose Regimen) in Patients Diagnosed With Alzheimer-Type Dementia Completed NCT00338117 Phase 3 Galantamine hydrobromide
2 Effects of Montelukast Therapy on Alzheimer's Disease (EMERALD) Recruiting NCT03991988 Phase 2 Montelukast;Placebo oral tablet
3 Magnetic Resonance Imaging Biomarkers in Amyotrophic Lateral Sclerosis Completed NCT02405182
4 Quantitative Assessment of the Retina Using Optical Coherence Tomography (OCT) and Fundus and Associations With Brain Function Recruiting NCT04226729
5 Closing the Loop on Tremor: A Responsive Deep Brain Stimulator for the Treatment of Essential Tremor Recruiting NCT02649166
6 The Motor Network in Essential Tremor: Mechanisms of Therapy Recruiting NCT02712515
7 Application of Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance Recruiting NCT03112902
8 Novel MRI Biomarkers for Monitoring Disease Progression in ALS Recruiting NCT03362658
9 Coaching for Cognition in Alzheimer's (COCOA) Recruiting NCT03424200
10 Dual Lead Thalamic DBR-DBS Interface for Closed Loop Control of Severe Essential Tremor Not yet recruiting NCT04212780
11 University of Washington Alzheimer's Disease Research Center (UW ADRC) Imaging & Biomarker Core Not yet recruiting NCT04437290 investigational radiotracer [18F]MK6240
12 Benefit of MRI and 18F-FDG PET Imaging in the Early Diagnosis of Alzheimer-like Dementia Terminated NCT01815112
13 Treating Sleep Wake Cycle Disturbances in Basal Ganglia Neurodegenerative Disorder Subjects With Ramelteon- A Double Blind, Placebo Controlled Trial Withdrawn NCT00907595 Ramelteon;Placebo

Search NIH Clinical Center for Cerebral Degeneration

Genetic Tests for Cerebral Degeneration

Anatomical Context for Cerebral Degeneration

MalaCards organs/tissues related to Cerebral Degeneration:

40
Brain, Retina, Cortex, Liver, Skin, Testes, Amygdala

Publications for Cerebral Degeneration

Articles related to Cerebral Degeneration:

(show top 50) (show all 183)
# Title Authors PMID Year
1
Multimodal longitudinal study of structural brain involvement in amyotrophic lateral sclerosis. 61
32414878 2020
2
Spectroscopic markers of neurodegeneration in the mesial prefrontal cortex predict survival in ALS. 61
32067510 2020
3
Reliability of 3D texture analysis: A multicenter MRI study of the brain. 61
31423714 2020
4
Salivary Redox Biomarkers in Selected Neurodegenerative Diseases. 61
32059422 2020
5
Cerebral degeneration in amyotrophic lateral sclerosis: A prospective multicenter magnetic resonance spectroscopy study. 61
31750025 2019
6
Quantifying changes on susceptibility weighted images in amyotrophic lateral sclerosis using MRI texture analysis. 61
31025885 2019
7
Leukoencephalopathy, Intracranial Calcifications, Cysts, and SNORD118 Mutation (Labrune Syndrome) with Obstructive Hydrocephalus. 61
30794980 2019
8
Management of concussion in soccer. 61
30687899 2019
9
Alabama Brief Cognitive Screener: Utility of a New Cognitive Screening Instrument in a Memory Disorders Clinic. 61
30896091 2019
10
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects of PF-06751979, a Potent and Selective Oral BACE1 Inhibitor: Results from Phase I Studies in Healthy Adults and Healthy Older Subjects. 61
31424395 2019
11
Antioxidant Defense, Redox Homeostasis, and Oxidative Damage in Children With Ataxia Telangiectasia and Nijmegen Breakage Syndrome. 61
31611883 2019
12
A study of the effects of 8-week acupuncture treatment on patients with Parkinson's disease. 61
30557997 2018
13
Evaluating the cerebral correlates of survival in amyotrophic lateral sclerosis. 61
30480029 2018
14
Texture Analysis to Detect Cerebral Degeneration in Amyotrophic Lateral Sclerosis. 61
30234470 2018
15
The role of Alu-derived RNAs in Alzheimer's and other neurodegenerative conditions. 61
29685192 2018
16
Interaction between the AAA ATPase p97/VCP and a concealed UBX domain in the copper transporter ATP7A is associated with motor neuron degeneration. 61
29599289 2018
17
A strategy to find novel candidate anti-Alzheimer's disease drugs by constructing interaction networks between drug targets and natural compounds in medical plants. 61
29770277 2018
18
Type-I interferons in Parkinson's disease: innate inflammatory response drives fate of neurons in model of degenerative brain disorder: An editorial comment on 'Type-I interferons mediate the neuroinflammatory response and neurotoxicity induced by rotenone'. 61
28332229 2017
19
Widespread temporo-occipital lobe dysfunction in amyotrophic lateral sclerosis. 61
28067298 2017
20
Abnormal Brain Connectivity Spectrum Disorders Following Thimerosal Administration: A Prospective Longitudinal Case-Control Assessment of Medical Records in the Vaccine Safety Datalink. 61
28539852 2017
21
Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication Stage V). 61
27716404 2016
22
Dispersion entropy for the analysis of resting-state MEG regularity in Alzheimer's disease. 61
28269715 2016
23
Crosstalk between 6-OHDA-induced autophagy and apoptosis in PC12 cells is mediated by phosphorylation of Raf-1/ERK1/2. 61
29442034 2016
24
Split Hand / Foot Malformation Syndrome with Cerebral Degeneration. 61
27730782 2016
25
High Content, Multi-Parameter Analyses in Buccal Cells to Identify Alzheimer's Disease. 61
26975368 2016
26
Cerebral Degeneration in Amyotrophic Lateral Sclerosis Revealed by 3-Dimensional Texture Analysis. 61
27064416 2016
27
Thimerosal exposure and increased risk for diagnosed tic disorder in the United States: a case-control study. 61
27486363 2015
28
Early detection of widespread progressive brain injury after cardiac arrest: a single case DTI and post-mortem histology study. 61
24633135 2014
29
[Genetic aspects of Alzheimer's disease (Review)]. 61
24035416 2013
30
Improved prediction of Alzheimer's disease with longitudinal white matter/gray matter contrast changes. 61
22674625 2013
31
Specific needs of dopamine neurons for stimulation in order to survive: implication for Parkinson disease. 61
23699175 2013
32
Mentalizing in preclinical Huntington's disease: an fMRI study using cartoon picture stories. 61
23179063 2013
33
Mitochondrial aldehyde dehydrogenase-2 activation prevents β-amyloid-induced endothelial cell dysfunction and restores angiogenesis. 61
23447675 2013
34
Phenotypic spectrum of COL4A1 mutations: porencephaly to schizencephaly. 61
23225343 2013
35
The response of cerebral cortex to haemorrhagic damage: experimental evidence from a penetrating injury model. 61
23555765 2013
36
Disease-specific expression of the serotonin-receptor 5-HT(2C) in natural killer cells in Alzheimer's dementia. 61
22766135 2012
37
Acupuncture stimulation on GB34 activates neural responses associated with Parkinson's disease. 61
22943145 2012
38
Fractional anisotropy of water diffusion in cerebral white matter across the lifespan. 61
20122755 2012
39
De novo and inherited mutations in COL4A2, encoding the type IV collagen α2 chain cause porencephaly. 61
22209246 2012
40
Intranasal treatment of neurodegenerative diseases and stroke. 61
22202044 2012
41
Transient improvement of acquired hepatocerebral degeneration with parkinsonian symptoms after failed liver transplant: case report and literature review. 61
22142042 2011
42
The multiple phenotypes of corticobasal syndrome and corticobasal degeneration: implications for further study. 61
21853287 2011
43
Association between environmental exposure to pesticides and neurodegenerative diseases. 61
21601587 2011
44
The extrinsic and intrinsic apoptotic pathways are involved in manganese toxicity in rat astrocytoma C6 cells. 61
21704098 2011
45
Punica granatum protects against oxidative stress in PC12 cells and oxidative stress-induced Alzheimer's symptoms in mice. 61
21631359 2011
46
Visual signs and symptoms of progressive supranuclear palsy. 61
20629667 2011
47
"Theory of mind" is impaired in Huntington's disease. 61
21384426 2011
48
Impulsive behavior and associated clinical variables in Parkinson's disease. 61
21300194 2011
49
Xanthene food dye, as a modulator of Alzheimer's disease amyloid-beta peptide aggregation and the associated impaired neuronal cell function. 61
21998691 2011
50
Progression of brain atrophy and cognitive decline in diabetes mellitus: a 3-year follow-up. 61
20837967 2010

Variations for Cerebral Degeneration

Expression for Cerebral Degeneration

Search GEO for disease gene expression data for Cerebral Degeneration.

Pathways for Cerebral Degeneration

Pathways related to Cerebral Degeneration according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.72 SLC25A17 ABCD2 ABCD1

GO Terms for Cerebral Degeneration

Cellular components related to Cerebral Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of peroxisomal membrane GO:0005779 8.96 SLC25A17 ABCD1
2 peroxisomal membrane GO:0005778 8.8 SLC25A17 ABCD2 ABCD1

Biological processes related to Cerebral Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of reactive oxygen species biosynthetic process GO:1903427 9.46 ABCD2 ABCD1
2 central nervous system myelination GO:0022010 9.43 PLP1 ASPA
3 neuron projection maintenance GO:1990535 9.4 ABCD2 ABCD1
4 positive regulation of fatty acid beta-oxidation GO:0032000 9.37 ABCD2 ABCD1
5 fatty acid beta-oxidation GO:0006635 9.33 SLC25A17 ABCD2 ABCD1
6 myelin maintenance GO:0043217 9.32 ABCD2 ABCD1
7 very long-chain fatty acid catabolic process GO:0042760 9.26 ABCD2 ABCD1
8 positive regulation of unsaturated fatty acid biosynthetic process GO:2001280 8.96 ABCD2 ABCD1
9 astrocyte development GO:0014002 8.8 PLP1 GFAP EIF2B5

Molecular functions related to Cerebral Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.17 NOTCH3 HTRA1 GFAP EPRS1 CRYAA ASPA

Sources for Cerebral Degeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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