MCID: CRB034
MIFTS: 29

Cerebral Hemisphere Lipoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Cerebral Hemisphere Lipoma

MalaCards integrated aliases for Cerebral Hemisphere Lipoma:

Name: Cerebral Hemisphere Lipoma 12 15 71
Lipoma of the Cerebral Hemisphere 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6291
NCIt 49 C6220
UMLS 71 C1332907

Summaries for Cerebral Hemisphere Lipoma

MalaCards based summary : Cerebral Hemisphere Lipoma, also known as lipoma of the cerebral hemisphere, is related to holoprosencephaly 7 and central nervous system lipoma. An important gene associated with Cerebral Hemisphere Lipoma is ALX3 (ALX Homeobox 3), and among its related pathways/superpathways are Pathways in cancer and Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. Affiliated tissues include spinal cord, skin and bone, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Cerebral Hemisphere Lipoma

Diseases related to Cerebral Hemisphere Lipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 holoprosencephaly 7 10.4 ZIC2 SIX3
2 central nervous system lipoma 10.4 ZIC2 SIX3 ALX3
3 munchausen by proxy 10.4 APELA ALX3
4 skin granular cell tumor 10.4 NF1 MAP2K1
5 patau syndrome 10.3 ZIC2 SIX3 SHH
6 factitious disorder 10.3 APELA ALX3
7 holoprosencephaly, recurrent infections, and monocytosis 10.3 SIX3 GLI2
8 melanotic medulloblastoma 10.3 SMARCB1 SHH
9 pica disease 10.2 PES1 LIG3
10 microcephaly and chorioretinopathy 1 10.2 PES1 LIG3
11 cerebellum cancer 10.2 SHH NF1
12 skin lipoma 10.2 NF1 FGFR1
13 cardiofaciocutaneous syndrome 1 10.2 NF1 MAP2K1 LIG3
14 epithelioid malignant peripheral nerve sheath tumor 10.2 SMARCB1 NF1
15 holoprosencephaly 9 10.2 ZIC2 SIX3 GLI2
16 syndromic craniosynostosis 10.2 MSX2 FGFR1
17 epithelioid neurofibroma 10.1 NF2 NF1
18 mayer-rokitansky-kuster-hauser syndrome 10.1 WNT9B SHOX
19 amyloid tumor 10.1 NF2 NF1
20 neurilemmoma of the fifth cranial nerve 10.1 NF2 NF1
21 trigeminal nerve neoplasm 10.1 NF2 NF1
22 plexiform schwannoma 10.1 NF2 NF1
23 small intestine leiomyoma 10.1 NF2 NF1
24 congenital hypopituitarism 10.1 SIX3 SHH GLI2
25 hypopituitarism 10.1 SIX3 SHH GLI2
26 lipomatosis, multiple 10.1 NF1 FGFR1 ALX3
27 skeletal muscle cancer 10.1 SMARCB1 SHH NF1
28 micronodular basal cell carcinoma 10.1 SHH GLI2
29 hemifacial microsomia 10.1 MSX2 FGFR1 ALX3
30 orbital cancer 10.1 NF2 NF1
31 hypertelorism, microtia, facial clefting syndrome 10.1 MSX2 FGFR1
32 polyp of corpus uteri 10.1 NF2 NF1
33 spinal cord oligodendroglioma 10.0 NF1 FGFR1
34 rete ovarii adenoma 10.0 NF2 NF1
35 rete ovarii neoplasm 10.0 NF2 NF1
36 brain stem glioma 10.0 SHH NF1 FGFR1
37 cellular schwannoma 10.0 NF2 NF1
38 monosomy 22 10.0 SMARCB1 NF2
39 saethre-chotzen syndrome 10.0 MSX2 FGFR1 ALX3
40 cleidocranial dysplasia 10.0 SHH MSX2 FGFR1
41 apert syndrome 10.0 SHH MSX2 FGFR1
42 cerebral falx meningioma 10.0 SMARCB1 NF2
43 adult medulloblastoma 10.0 SHH GLI2
44 anterior cranial fossa meningioma 10.0 SMARCB1 NF2
45 midline interhemispheric variant of holoprosencephaly 10.0 ZIC2 SIX3 SHH GLI2
46 septopreoptic holoprosencephaly 10.0 ZIC2 SIX3 SHH GLI2
47 holoprosencephaly 1 10.0 ZIC2 SIX3 SHH GLI2
48 holoprosencephaly 5 10.0 ZIC2 SIX3 SHH GLI2
49 holoprosencephaly 2 10.0 ZIC2 SIX3 SHH GLI2
50 holoprosencephaly 4 10.0 ZIC2 SIX3 SHH GLI2

Graphical network of the top 20 diseases related to Cerebral Hemisphere Lipoma:



Diseases related to Cerebral Hemisphere Lipoma

Symptoms & Phenotypes for Cerebral Hemisphere Lipoma

GenomeRNAi Phenotypes related to Cerebral Hemisphere Lipoma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00107-A-1 10.26 MAP2K1
2 Decreased viability GR00221-A-1 10.26 FGFR1 GLI2 NF1 SMARCB1
3 Decreased viability GR00221-A-2 10.26 CHEK2 FGFR1 GLI2 NF1 SMARCB1
4 Decreased viability GR00221-A-3 10.26 CHEK2 SMARCB1 MAP2K1 NF2 SHH
5 Decreased viability GR00221-A-4 10.26 CHEK2 NF1
6 Decreased viability GR00342-S-1 10.26 MAP2K1
7 Decreased viability GR00342-S-2 10.26 CHEK2 MAP2K1
8 Decreased viability GR00342-S-3 10.26 MAP2K1
9 Decreased viability GR00381-A-1 10.26 SMARCB1
10 Decreased viability GR00402-S-2 10.26 CHEK2 FGFR1 GLI2 NF1 SMARCB1 MAP2K1
11 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

MGI Mouse Phenotypes related to Cerebral Hemisphere Lipoma:

45 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.43 ALX3 FGFR1 GLI2 LHX8 LIG3 MAP2K1
2 embryo MP:0005380 10.42 ALX3 FGFR1 GLI2 LIG3 MAP2K1 MSX2
3 mortality/aging MP:0010768 10.39 ALX3 CHEK2 FGFR1 GLI2 LHX8 LIG3
4 craniofacial MP:0005382 10.38 ALX3 FGFR1 GLI2 LHX8 MAP2K1 MSX2
5 cellular MP:0005384 10.35 ALX3 CHEK2 FGFR1 GLI2 LHX8 LIG3
6 digestive/alimentary MP:0005381 10.34 ALX3 FGFR1 GLI2 LHX8 MAP2K1 MSX2
7 behavior/neurological MP:0005386 10.32 ALX3 FGFR1 GLI2 LHX8 LIG3 MSX2
8 endocrine/exocrine gland MP:0005379 10.24 ALX3 CHEK2 FGFR1 GLI2 MAP2K1 MSX2
9 nervous system MP:0003631 10.21 ALX3 CHEK2 FGFR1 GLI2 LHX8 LIG3
10 integument MP:0010771 10.15 FGFR1 GLI2 MAP2K1 MSX2 NF1 NF2
11 limbs/digits/tail MP:0005371 10.08 ALX3 FGFR1 GLI2 MSX2 NF1 SHH
12 hearing/vestibular/ear MP:0005377 10.05 FGFR1 GLI2 MAP2K1 MSX2 NF1 NF2
13 reproductive system MP:0005389 10 ALX3 CHEK2 FGFR1 GLI2 MAP2K1 NF1
14 muscle MP:0005369 9.98 FGFR1 GLI2 LIG3 MSX2 NF1 SHH
15 normal MP:0002873 9.92 FGFR1 GLI2 MAP2K1 MSX2 NF1 SHH
16 neoplasm MP:0002006 9.88 CHEK2 MAP2K1 NF1 NF2 SHH SMARCB1
17 respiratory system MP:0005388 9.7 ALX3 GLI2 NF1 NF2 SHH SIX3
18 skeleton MP:0005390 9.65 ALX3 FGFR1 GLI2 MAP2K1 MSX2 NF1
19 vision/eye MP:0005391 9.36 ALX3 FGFR1 GLI2 MAP2K1 MSX2 NF1

Drugs & Therapeutics for Cerebral Hemisphere Lipoma

Search Clinical Trials , NIH Clinical Center for Cerebral Hemisphere Lipoma

Genetic Tests for Cerebral Hemisphere Lipoma

Anatomical Context for Cerebral Hemisphere Lipoma

MalaCards organs/tissues related to Cerebral Hemisphere Lipoma:

40
Spinal Cord, Skin, Bone, Brain, Cerebellum, Skeletal Muscle, Small Intestine

Publications for Cerebral Hemisphere Lipoma

Variations for Cerebral Hemisphere Lipoma

Expression for Cerebral Hemisphere Lipoma

Search GEO for disease gene expression data for Cerebral Hemisphere Lipoma.

Pathways for Cerebral Hemisphere Lipoma

GO Terms for Cerebral Hemisphere Lipoma

Cellular components related to Cerebral Hemisphere Lipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.63 SMARCB1 SIX3 SHOX MSX2 LHX8 ALX3
2 nucleus GO:0005634 9.5 ZIC2 SMARCB1 SIX3 SHOX PES1 NF2
3 nucleolus GO:0005730 9.43 SMARCB1 PES1 NF2 NF1 GLI2 FGFR1

Biological processes related to Cerebral Hemisphere Lipoma according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 10.23 SIX3 SHOX SHH MSX2 LHX8 CHEK2
2 positive regulation of transcription, DNA-templated GO:0045893 10.08 ZIC2 SHH MAP2K1 GLI2 CHEK2
3 negative regulation of cell proliferation GO:0008285 10.02 SMARCB1 NF2 NF1 MSX2 MAP2K1
4 brain development GO:0007420 9.89 ZIC2 SIX3 NF2 NF1 FGFR1
5 neuron differentiation GO:0030182 9.87 WNT9B WNT3 MAP2K1 LHX8
6 kidney development GO:0001822 9.86 WNT9B SHH GLI2
7 osteoblast differentiation GO:0001649 9.85 NF1 MSX2 GLI2
8 heart development GO:0007507 9.85 SHH NF1 MAP2K1 GLI2 APELA
9 lung development GO:0030324 9.84 SHH GLI2 FGFR1
10 canonical Wnt signaling pathway GO:0060070 9.82 WNT9B WNT3 SHH
11 anterior/posterior pattern specification GO:0009952 9.81 WNT3 SHH MSX2 GLI2
12 regulation of cell proliferation GO:0042127 9.8 SIX3 SHH NF2 NF1 FGFR1
13 cell fate commitment GO:0045165 9.79 WNT9B WNT3 SHH
14 pattern specification process GO:0007389 9.77 SHH GLI2 ALX3
15 embryonic digit morphogenesis GO:0042733 9.77 SHH MSX2 GLI2
16 embryonic limb morphogenesis GO:0030326 9.76 SHH MSX2 FGFR1
17 anatomical structure development GO:0048856 9.73 SIX3 SHH GLI2
18 placenta blood vessel development GO:0060674 9.68 MAP2K1 APELA
19 dorsal/ventral neural tube patterning GO:0021904 9.67 SHH GLI2
20 ectoderm development GO:0007398 9.67 SHH NF2
21 lens fiber cell differentiation GO:0070306 9.66 SIX3 NF2
22 branching involved in salivary gland morphogenesis GO:0060445 9.66 SHH FGFR1
23 limb bud formation GO:0060174 9.65 WNT3 SHH
24 positive regulation of T cell differentiation in thymus GO:0033089 9.65 SHH GLI2
25 mammary gland epithelium development GO:0061180 9.65 WNT3 MSX2
26 branching morphogenesis of an epithelial tube GO:0048754 9.65 WNT9B SHH GLI2
27 regulation of neural precursor cell proliferation GO:2000177 9.64 SIX3 NF2
28 lung-associated mesenchyme development GO:0060484 9.63 SHH FGFR1
29 Bergmann glial cell differentiation GO:0060020 9.63 SHH MAP2K1
30 odontogenesis of dentin-containing tooth GO:0042475 9.62 SHH NF2 LHX8 GLI2
31 regulation of protein localization to nucleus GO:1900180 9.61 SHH NF2
32 telencephalon regionalization GO:0021978 9.61 SIX3 SHH
33 osteoblast development GO:0002076 9.61 SHH MSX2 GLI2
34 spinal cord dorsal/ventral patterning GO:0021513 9.58 SHH GLI2
35 positive regulation of cell differentiation GO:0045597 9.56 SHH NF2 MAP2K1 FGFR1
36 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.55 SHH GLI2
37 hindgut morphogenesis GO:0007442 9.54 SHH GLI2
38 anatomical structure formation involved in morphogenesis GO:0048646 9.54 WNT3 SHH GLI2
39 ventral midline development GO:0007418 9.52 SHH GLI2
40 embryonic forelimb morphogenesis GO:0035115 9.46 WNT3 SHH MSX2 ALX3
41 multicellular organism development GO:0007275 9.32 ZIC2 WNT9B WNT3 SIX3 SHOX SHH
42 embryonic hindlimb morphogenesis GO:0035116 9.26 WNT3 SHH MSX2 ALX3

Molecular functions related to Cerebral Hemisphere Lipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.81 ZIC2 SMARCB1 SIX3 SHOX MSX2 LIG3
2 sequence-specific DNA binding GO:0043565 9.43 SIX3 SHOX MSX2 LHX8 GLI2 ALX3
3 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.17 ZIC2 SIX3 SHOX MSX2 LHX8 GLI2

Sources for Cerebral Hemisphere Lipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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