MCID: CRB090
MIFTS: 46

Cerebral Hypoxia

Categories: Neuronal diseases

Aliases & Classifications for Cerebral Hypoxia

MalaCards integrated aliases for Cerebral Hypoxia:

Name: Cerebral Hypoxia 54 55
Brain Hypoxia 73

Classifications:



External Ids:

UMLS 73 C1527348

Summaries for Cerebral Hypoxia

NINDS : 54 Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.  In brain death, there is no measurable activity in the brain, although cardiovascular function is preserved. Life support is required for respiration.

MalaCards based summary : Cerebral Hypoxia, also known as brain hypoxia, is related to traumatic brain injury and hypoxia. An important gene associated with Cerebral Hypoxia is CAMK4 (Calcium/Calmodulin Dependent Protein Kinase IV), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Sevoflurane and Propofol have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and endothelial, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

Wikipedia : 76 Cerebral hypoxia is a form of hypoxia (reduced supply of oxygen), specifically involving the brain; when... more...

Related Diseases for Cerebral Hypoxia

Diseases related to Cerebral Hypoxia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 traumatic brain injury 29.1 CASP3 IGF1
2 hypoxia 11.6
3 anoxia 11.5
4 brain ischemia 11.0
5 cerebritis 10.8
6 ischemia 10.6
7 neuronitis 10.2
8 brain injury 10.0
9 cardiac arrest 9.8
10 aging 9.7
11 encephalopathy 9.7
12 cerebral artery occlusion 9.7
13 dementia 9.7
14 endotheliitis 9.7
15 moyamoya disease 1 9.6
16 laryngitis 9.6
17 neuroblastoma 9.6
18 lactic acidosis 9.6
19 sudden infant death syndrome 9.6
20 dystonia 9.6
21 intracranial hypertension 9.6
22 wallerian degeneration 9.6
23 focal dystonia 9.6
24 myoclonus 9.6
25 pulmonary edema 9.6
26 syncope 9.6
27 vascular disease 9.6
28 epilepsy 9.6
29 ocular dominance 9.2 CREB1 NOS1
30 myeloma, multiple 9.0 CASP3 CASP9 IGF1
31 breast cancer 7.4 BCAR1 CASP3 CASP9 FOS IGF1 ITGB1

Graphical network of the top 20 diseases related to Cerebral Hypoxia:



Diseases related to Cerebral Hypoxia

Symptoms & Phenotypes for Cerebral Hypoxia

GenomeRNAi Phenotypes related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.92 CASP3 IGF1 PTK2
2 Decreased viability with paclitaxel GR00179-A-2 8.92 IGF1

MGI Mouse Phenotypes related to Cerebral Hypoxia:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.31 BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
2 growth/size/body region MP:0005378 10.26 BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
3 endocrine/exocrine gland MP:0005379 10.24 IGF1 ITGAV ITGB1 NOS1 PTK2 CAMK4
4 cardiovascular system MP:0005385 10.23 BCAR1 CASP3 CASP9 CREB1 IGF1 ITGAV
5 mortality/aging MP:0010768 10.17 CAMK4 CASP3 CASP9 CREB1 FOS IGF1
6 hematopoietic system MP:0005397 10.16 IGF1 ITGAV ITGB1 NOS1 PTK2 CAMK4
7 homeostasis/metabolism MP:0005376 10.15 CAMK4 CASP3 CREB1 FOS IGF1 ITGAV
8 immune system MP:0005387 10.13 CAMK4 CASP3 CASP9 FOS IGF1 ITGAV
9 embryo MP:0005380 10.09 BCAR1 CASP9 CREB1 FOS ITGAV ITGB1
10 nervous system MP:0003631 10.02 CAMK4 CASP3 CASP9 CREB1 FOS PTK2
11 muscle MP:0005369 10.01 BCAR1 CASP3 CREB1 IGF1 ITGAV ITGB1
12 craniofacial MP:0005382 9.96 CASP3 CASP9 FOS ITGAV ITGB1
13 integument MP:0010771 9.93 CAMK4 CASP3 FOS IGF1 ITGB1 PTK2
14 normal MP:0002873 9.8 FOS IGF1 ITGB1 NOS1 PTK2 CAMK4
15 neoplasm MP:0002006 9.77 FOS IGF1 ITGAV ITGB1 PTK2
16 reproductive system MP:0005389 9.76 CAMK4 CASP3 CREB1 FOS IGF1 ITGB1
17 respiratory system MP:0005388 9.5 CASP3 CASP9 CREB1 IGF1 ITGB1 NOS1
18 skeleton MP:0005390 9.17 CAMK4 CASP3 CREB1 FOS IGF1 ITGB1

Drugs & Therapeutics for Cerebral Hypoxia

Drugs for Cerebral Hypoxia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
4
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
5
Racepinephrine Approved Phase 4 329-65-7 838
6 Ether Phase 4
7 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
8 Anesthetics Phase 4,Phase 2,Not Applicable
9 Anesthetics, General Phase 4,Phase 2
10 Anesthetics, Inhalation Phase 4,Phase 2
11 Anesthetics, Intravenous Phase 4
12 Epinephryl borate Phase 4
13 Hypnotics and Sedatives Phase 4
14 Platelet Aggregation Inhibitors Phase 4
15
Mannitol Approved, Investigational Phase 3 69-65-8 453 6251
16 diuretics Phase 3
17 Natriuretic Agents Phase 3
18 Xenon Phase 2
19
Temozolomide Approved, Investigational 85622-93-1 5394
20
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
21
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
22
Glutamic Acid Approved, Nutraceutical Not Applicable 56-86-0 33032
23 tannic acid Approved, Nutraceutical Not Applicable
24 Dopamine agonists Not Applicable
25 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol Not Applicable
26 Neurotransmitter Agents Not Applicable
27 Tranquilizing Agents Not Applicable
28 Dopamine Agents Not Applicable
29 Antipsychotic Agents Not Applicable
30 Psychotropic Drugs Not Applicable

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Sevoflurane Decreases the Risk of Postoperative Delirium After Cerebral Hypoxemia During Surgery Unknown status NCT02133638 Phase 4 Sevoflurane;Propofol
2 Sodium Bicarbonate in Cardiopulmonary Resuscitation Unknown status NCT01377337 Phase 4 sodium bicarbonate
3 Hypertonic Saline vs. Mannitol for Elevated Intercranial Pressure Terminated NCT01111682 Phase 3 Mannitol;Hypertonic Saline
4 Effect of Xenon and Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest Patients Completed NCT00879892 Phase 2 xenon
5 Home Stimulation for Brain-Asphyxiated Infants Completed NCT00006516 Phase 2
6 CO2 (Carbon Dioxide) - Cerebral Oxygenation Recruiting NCT03338907 Phase 2 Oxycarbon (5% CO2+ 95% O2)
7 The Effects of Hypobaria vs Hypoxia on Cerebral Functions. Completed NCT03303118 Not Applicable
8 Feasibility Trial to Maintain Normal Cerebral Oxygen Saturation in High-Risk Cardiac Surgery Completed NCT01432184 Not Applicable
9 The Difference in Cerebral Oxygenation Between Propofol and Sevoflurane Completed NCT01757561
10 The Impact of a Beach Chair Position During Shoulder Arthroscopy on Regional Cerebral Oxygen Saturation : Comparison of Interscalene Block and General Anesthesia Completed NCT02605005
11 Cerebral Responses During Exercise in Hypoxia Completed NCT01614119 Not Applicable
12 Magnetic Resonance Biomarkers in Neonatal Encephalopathy Completed NCT01309711
13 Septic Shock and Delirium Because of rSO2 Abnormalities in Intensive Care Unit Patients (The SAD BRAIN Study) Completed NCT01836302
14 Near INfrared Spectroscopy in Aortic valvE ReplacemenT Completed NCT01251328 Not Applicable
15 CRRT for Glutamate Elimination After Cardiac Arrest Completed NCT02963298 Not Applicable
16 Retrospective Evaluation of Melanocortin Receptor 4 Polymorphisms in Patients With GBM Treated With Radiochemotherapy Completed NCT02458508
17 Observational Study in Preterm Infants With Intracranial Hemorrhage Recruiting NCT01620203
18 Correlating Brain Tissue Oxygen and Regional Cerebral Oximetry Recruiting NCT03128957 Not Applicable
19 Impact of Early Optimization of Brain Oxygenation on Neurological Outcome After Severe Traumatic Brain Injury Recruiting NCT02754063 Not Applicable
20 Lactate Therapy After Traumatic Brain Injury Recruiting NCT01573507 Not Applicable
21 Role of Active Deresuscitation After Resuscitation-2 Recruiting NCT03512392 Not Applicable
22 Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia Active, not recruiting NCT02482571 Not Applicable
23 A Prospective Study With a New Device for the Monitoring of Cerebral Oxygenation on Cardiac Surgery Patients Terminated NCT00598936
24 Continuous Neurophysiological Monitoring Detection of Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage Subjects Terminated NCT01343537 Early Phase 1

Search NIH Clinical Center for Cerebral Hypoxia

Genetic Tests for Cerebral Hypoxia

Anatomical Context for Cerebral Hypoxia

MalaCards organs/tissues related to Cerebral Hypoxia:

41
Brain, Cortex, Endothelial, Monocytes, Lung, Spleen

Publications for Cerebral Hypoxia

Articles related to Cerebral Hypoxia:

(show top 50) (show all 264)
# Title Authors Year
1
Nocturnal cerebral hypoxia in obstructive sleep apnoea: a randomised controlled trial. ( 29700104 )
2018
2
Yap-Hippo pathway regulates cerebral hypoxia-reoxygenation injury in neuroblastoma N2a cells via inhibiting ROCK1/F-actin/mitochondrial fission pathways. ( 29796942 )
2018
3
Neuronal nitric oxide synthase inhibition reduces brain damage by promoting collateral recruitment in a cerebral hypoxia-ischemia mice model. ( 29863262 )
2018
4
Ameliorative Effect of Trans-Sinapic Acid and its Protective Role in Cerebral Hypoxia in Aluminium Chloride Induced Dementia of Alzheimer's Type. ( 29521253 )
2018
5
Noninvasive detection of acute cerebral hypoxia and subsequent matrix-metalloproteinase activity in a mouse model of cerebral ischemia using multispectral-optoacoustic-tomography. ( 29531962 )
2018
6
Magnesium sulphate induces preconditioning in preterm rodent models of cerebral hypoxia-ischemia. ( 29355709 )
2018
7
NMNAT3 is protective against the effects of neonatal cerebral hypoxia-ischemia. ( 29046881 )
2017
8
Cerebral Hypoxia Caused by Flow Confliction During Minimally Invasive Cardiac Surgery With Retrograde Perfusion: A Word of Caution. ( 29126685 )
2017
9
Effect of Intranasally Delivered rh-VEGF165 on Angiogenesis Following Cerebral Hypoxia-Ischemia in the Cerebral Cortex of Newborn Piglets. ( 29112164 )
2017
10
The relationship between the Trendelenburg position and cerebral hypoxia inpatients who have undergone robot-assisted hysterectomy and prostatectomy ( 29306241 )
2017
11
The role of SUMOylation in cerebral hypoxia and ischemia. ( 28323006 )
2017
12
Persistent generalized periodic discharges: A specific marker of fatal outcome in cerebral hypoxia. ( 27894023 )
2017
13
Cerebral hypoxia during immediate transition after birth and short term neurological outcome. ( 28472725 )
2017
14
Effect of Src Kinase inhibition on Cytochrome c, Smac/DIABLO and Apoptosis Inducing Factor (AIF) Following Cerebral Hypoxia-Ischemia in Newborn Piglets. ( 29192254 )
2017
15
Preceding functional tooth loss delays recovery from acute cerebral hypoxia and locomotor hypoactivity after murine subarachnoid haemorrhage. ( 29044603 )
2017
16
Quantifying cerebral hypoxia by near-infrared spectroscopy tissue oximetry: the role of arterial-to-venous blood volume ratio. ( 28152128 )
2017
17
Administration of Huperzia quadrifariata Extract, a Cholinesterase Inhibitory Alkaloid Mixture, has Neuroprotective Effects in a Rat Model of Cerebral Hypoxia-Ischemia. ( 27885575 )
2017
18
The SafeBoosC II randomized trial: treatment guided by near-infrared spectroscopy reduces cerebral hypoxia without changing early biomarkers of brain injury. ( 26679155 )
2016
19
Application of a novel rectal cooling device in hypothermia therapy after cerebral hypoxia-ischemia in rats. ( 27613331 )
2016
20
Cerebral hypoxia/ischemia selectively disrupts tight junctions complexes in stem cell-derived human brain microvascular endothelial cells. ( 27724968 )
2016
21
Translational challenge models in support of efficacy studies: effect of cerebral hypoxia on cognitive performances in rodents. ( 27189464 )
2016
22
Does cerebral hypoxia facilitate central fatigue? ( 26891346 )
2016
23
Genetic deletion of neuronal pentraxin 1 expression prevents brain injury in a neonatal mouse model of cerebral hypoxia-ischemia. ( 25554688 )
2015
24
Neuronal death after perinatal cerebral hypoxia-ischemia: Focus on autophagy-mediated cell death. ( 26225751 )
2015
25
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia. ( 26325524 )
2015
26
Prophylactic Subacute Administration of Zinc Increases CCL2, CCR2, FGF2, and IGF-1 Expression and Prevents the Long-Term Memory Loss in a Rat Model of Cerebral Hypoxia-Ischemia. ( 26355725 )
2015
27
Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia. ( 26437227 )
2015
28
Poloxamer 188 Attenuates Cerebral Hypoxia/Ischemia Injury in Parallel with Preventing Mitochondrial Membrane Permeabilization and Autophagic Activation. ( 25966641 )
2015
29
Brain barrier properties and cerebral blood flow in neonatal mice exposed to cerebral hypoxia-ischemia. ( 25627141 )
2015
30
Cerebral hypoxia-ischemia increases toll-like receptor 2 and 4 expression in the hippocampus of neonatal rats. ( 25530127 )
2014
31
Cerebral hypoxia-ischemia causes cardiac damage in a rat model. ( 24840931 )
2014
32
Cerebral hypoxia, missing cortical somatosensory evoked potentials and recovery of consciousness. ( 24720818 )
2014
33
Catatonia After Cerebral Hypoxia: Do the Usual Treatments Apply? ( 25262046 )
2014
34
A combination of mild hypothermia and sevoflurane affords long-term protection in a modified neonatal mouse model of cerebral hypoxia-ischemia. ( 24878681 )
2014
35
Therapeutic benefits of delayed lithium administration in the neonatal rat after cerebral hypoxia-ischemia. ( 25211332 )
2014
36
Evaluation of 2-[A^a8,F]fluoroacetate kinetics in rodent models of cerebral hypoxia-ischemia. ( 24517980 )
2014
37
Cerebral hypoxia immediately following delivery of very low birth weight infants. ( 24393297 )
2014
38
The impact of Ly6Clow monocytes after cerebral hypoxia-ischemia in adult mice. ( 24780898 )
2014
39
Simulating NIRS and MRS measurements during cerebral hypoxia-ischaemia in piglets using a computational model. ( 24729232 )
2014
40
Brain mitochondrial oxidative metabolism during and after cerebral hypoxia-ischemia studied by simultaneous phosphorus magnetic-resonance and broadband near-infrared spectroscopy. ( 23959202 )
2013
41
Pathology of the right ventricle: a comparison between traumatic brain injury, afterload mismatch and cerebral hypoxia. ( 23375752 )
2013
42
Erythropoietin: a neuroprotective agent in cerebral hypoxia, neurodegeneration, and epilepsy. ( 23530506 )
2013
43
Subacute zinc administration and L-NAME caused an increase of NO, zinc, lipoperoxidation, and caspase-3 during a cerebral hypoxia-ischemia process in the rat. ( 23997853 )
2013
44
Cerebral hypoxia in a cat following pharyngoscopy involving use of a mouth gag. ( 22924887 )
2013
45
Amiloride but not memantine reduces neurodegeneration, seizures and myoclonic jerks in rats with cardiac arrest-induced global cerebral hypoxia and reperfusion. ( 23593189 )
2013
46
Targeted drug delivery to treat pain and cerebral hypoxia. ( 23343976 )
2013
47
Use of serum biomarkers to predict cerebral hypoxia after severe traumatic brain injury. ( 22360297 )
2012
48
Chronic cerebral hypoxia promotes arteriogenic remodeling events that can be identified by reduced endoglin (CD105) expression and a switch in I^1 integrins. ( 22739620 )
2012
49
Cognitive decline in moyamoya: influence of chronic cerebral hypoxia, history of stroke, or comorbid conditions? ( 22171927 )
2012
50
The increased activity of TRPV4 channel in the astrocytes of the adult rat hippocampus after cerebral hypoxia/ischemia. ( 22761937 )
2012

Variations for Cerebral Hypoxia

Expression for Cerebral Hypoxia

Search GEO for disease gene expression data for Cerebral Hypoxia.

Pathways for Cerebral Hypoxia

Pathways related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.08 BCAR1 CAMK4 CASP3 CASP9 CREB1 IGF1
2
Show member pathways
13.93 CAMK4 CASP3 CASP9 CREB1 FOS ITGAV
3
Show member pathways
13.78 CASP3 CASP9 CREB1 FOS IGF1 ITGAV
4
Show member pathways
13.75 BCAR1 CASP3 CASP9 CREB1 FOS IGF1
5
Show member pathways
13.63 BCAR1 CAMK4 CREB1 FOS IGF1 ITGAV
6
Show member pathways
13.34 BCAR1 CASP3 CREB1 FOS ITGAV ITGB1
7
Show member pathways
13.3 CASP3 CASP9 CREB1 FOS IGF1 ITGAV
8
Show member pathways
13.25 BCAR1 IGF1 ITGAV ITGB1 NOS1 PTK2
9
Show member pathways
13.23 CASP3 CASP9 FOS IGF1 PTK2
10
Show member pathways
12.97 BCAR1 CAMK4 CASP3 FOS IGF1 PTK2
11
Show member pathways
12.96 BCAR1 CAMK4 CREB1 IGF1 ITGAV ITGB1
12
Show member pathways
12.88 CASP3 CASP9 CREB1 IGF1 ITGAV ITGB1
13
Show member pathways
12.87 BCAR1 FOS ITGAV ITGB1 NOS1 PTK2
14
Show member pathways
12.86 BCAR1 FOS IGF1 ITGB1 PTK2
15
Show member pathways
12.84 BCAR1 FOS IGF1 ITGAV ITGB1 PTK2
16
Show member pathways
12.77 CASP3 CASP9 FOS IGF1
17
Show member pathways
12.77 CAMK4 CREB1 FOS ITGAV ITGB1 PTK2
18
Show member pathways
12.76 CAMK4 CASP9 CREB1 IGF1 ITGAV ITGB1
19
Show member pathways
12.72 CASP9 FOS IGF1 PTK2
20 12.72 CASP3 CASP9 FOS IGF1
21 12.72 CASP3 CASP9 FOS IGF1 ITGAV ITGB1
22
Show member pathways
12.59 BCAR1 ITGAV ITGB1 PTK2
23 12.58 BCAR1 ITGAV ITGB1 PTK2
24
Show member pathways
12.57 CASP9 FOS ITGB1 NOS1 PTK2
25
Show member pathways
12.53 BCAR1 CASP9 IGF1 PTK2
26
Show member pathways
12.53 CASP3 CASP9 CREB1 FOS
27
Show member pathways
12.5 CAMK4 CREB1 FOS NOS1
28
Show member pathways
12.5 CAMK4 CASP3 CASP9 FOS PTK2
29
Show member pathways
12.5 BCAR1 CASP3 CASP9 CREB1 FOS IGF1
30
Show member pathways
12.47 CASP3 CASP9 FOS
31
Show member pathways
12.45 CASP3 CREB1 FOS ITGB1 PTK2
32
Show member pathways
12.45 BCAR1 CASP3 CASP9 FOS IGF1 ITGB1
33
Show member pathways
12.43 CAMK4 CASP3 CASP9 CREB1 FOS NOS1
34
Show member pathways
12.41 CASP3 CASP9 ITGAV ITGB1 PTK2
35
Show member pathways
12.37 CASP9 CREB1 FOS ITGAV PTK2
36
Show member pathways
12.37 BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
37
Show member pathways
12.36 CASP3 CASP9 CREB1 IGF1
38
Show member pathways
12.29 CAMK4 CREB1 FOS
39
Show member pathways
12.28 CAMK4 CREB1 IGF1
40 12.26 CASP3 IGF1 ITGAV ITGB1 PTK2
41
Show member pathways
12.25 CAMK4 CREB1 FOS
42
Show member pathways
12.24 CASP3 CASP9 FOS ITGB1
43
Show member pathways
12.22 CASP3 CASP9 FOS
44 12.2 CASP3 CASP9 CREB1
45
Show member pathways
12.19 ITGAV ITGB1 PTK2
46
Show member pathways
12.18 IGF1 ITGAV ITGB1
47
Show member pathways
12.18 CASP3 CREB1 FOS
48
Show member pathways
12.17 CASP3 CASP9 IGF1
49 12.17 BCAR1 CREB1 FOS PTK2
50
Show member pathways
12.17 BCAR1 CASP9 CREB1 FOS ITGAV ITGB1

GO Terms for Cerebral Hypoxia

Cellular components related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lamellipodium GO:0030027 9.43 BCAR1 ITGB1 PTK2
2 dendritic spine GO:0043197 9.33 ITGB1 NOS1 PTK2
3 integrin complex GO:0008305 9.32 ITGAV ITGB1
4 focal adhesion GO:0005925 9.26 BCAR1 ITGAV ITGB1 PTK2
5 alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867 8.62 IGF1 ITGAV

Biological processes related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.93 IGF1 ITGAV ITGB1 PTK2
2 positive regulation of transcription, DNA-templated GO:0045893 9.89 CAMK4 CREB1 FOS IGF1 NOS1
3 positive regulation of apoptotic process GO:0043065 9.84 CASP3 CASP9 CREB1 ITGB1
4 extracellular matrix organization GO:0030198 9.82 ITGAV ITGB1 PTK2
5 aging GO:0007568 9.8 CASP9 CREB1 FOS
6 response to hypoxia GO:0001666 9.8 CASP3 CREB1 NOS1
7 response to organic cyclic compound GO:0014070 9.74 CASP3 CASP9 FOS
8 positive regulation of cell migration GO:0030335 9.73 BCAR1 IGF1 ITGAV PTK2
9 response to organic substance GO:0010033 9.7 CASP3 CREB1 IGF1
10 response to lipopolysaccharide GO:0032496 9.67 CASP3 CASP9 FOS NOS1
11 response to antibiotic GO:0046677 9.65 CASP3 CASP9
12 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.65 BCAR1 ITGAV PTK2
13 ERK1 and ERK2 cascade GO:0070371 9.64 IGF1 ITGAV
14 positive regulation of cardiac muscle hypertrophy GO:0010613 9.62 IGF1 PTK2
15 heterotypic cell-cell adhesion GO:0034113 9.61 ITGAV ITGB1
16 positive regulation of osteoclast differentiation GO:0045672 9.61 CREB1 FOS
17 platelet formation GO:0030220 9.6 CASP3 CASP9
18 cell-substrate adhesion GO:0031589 9.59 ITGAV ITGB1
19 cell adhesion mediated by integrin GO:0033627 9.58 ITGAV ITGB1
20 negative regulation of anoikis GO:2000811 9.58 ITGB1 PTK2
21 neurotrophin TRK receptor signaling pathway GO:0048011 9.56 BCAR1 CASP3
22 cellular response to hepatocyte growth factor stimulus GO:0035729 9.55 BCAR1 CREB1
23 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 9.51 CASP3 CASP9
24 protein kinase B signaling GO:0043491 9.5 CASP9 CREB1 IGF1
25 response to cobalt ion GO:0032025 9.46 CASP3 CASP9
26 execution phase of apoptosis GO:0097194 9.43 CASP3 CASP9 PTK2
27 glial cell apoptotic process GO:0034349 9.4 CASP3 CASP9
28 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.33 CASP3 CASP9 ITGAV
29 transforming growth factor beta receptor signaling pathway GO:0007179 9.26 CREB1 FOS ITGB1 PTK2
30 integrin-mediated signaling pathway GO:0007229 8.92 BCAR1 ITGAV ITGB1 PTK2

Molecular functions related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibronectin binding GO:0001968 9.4 ITGAV ITGB1
2 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001190 9.37 CREB1 FOS
3 integrin binding GO:0005178 9.33 IGF1 ITGAV ITGB1
4 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.32 CASP3 CASP9
5 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 9.26 CASP3 CASP9
6 protease binding GO:0002020 9.13 CASP3 ITGAV ITGB1
7 C-X3-C chemokine binding GO:0019960 8.62 ITGAV ITGB1

Sources for Cerebral Hypoxia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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