MCID: CRB090
MIFTS: 47

Cerebral Hypoxia

Categories: Neuronal diseases

Aliases & Classifications for Cerebral Hypoxia

MalaCards integrated aliases for Cerebral Hypoxia:

Name: Cerebral Hypoxia 54 55
Brain Hypoxia 73

Classifications:



External Ids:

UMLS 73 C1527348

Summaries for Cerebral Hypoxia

NINDS : 54 Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.  In brain death, there is no measurable activity in the brain, although cardiovascular function is preserved. Life support is required for respiration.

MalaCards based summary : Cerebral Hypoxia, also known as brain hypoxia, is related to ischemia and traumatic brain injury. An important gene associated with Cerebral Hypoxia is CAMK4 (Calcium/Calmodulin Dependent Protein Kinase IV), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Sevoflurane and Propofol have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and kidney, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

Wikipedia : 76 Cerebral hypoxia is a form of hypoxia (reduced supply of oxygen), specifically involving the brain; when... more...

Related Diseases for Cerebral Hypoxia

Diseases related to Cerebral Hypoxia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 ischemia 30.5 CASP3 CASP9 NOS1
2 traumatic brain injury 29.8 CASP3 IGF1
3 hypoxia 11.8
4 brain ischemia 11.1
5 brain injury 10.1
6 morphine dependence 10.0 CREB1 FOS
7 cardiac arrest 9.9
8 disuse amblyopia 9.8 FOS NOS1
9 ocular dominance 9.8 CREB1 NOS1
10 cerebral artery occlusion 9.8
11 dementia 9.8
12 encephalopathy 9.8
13 myeloma, multiple 9.7 CASP3 CASP9 IGF1
14 moyamoya disease 1 9.7
15 neuroblastoma 9.7
16 sudden infant death syndrome 9.7
17 focal dystonia 9.7
18 pulmonary edema 9.7
19 patulous eustachian tube 9.7
20 vascular disease 9.7
21 epilepsy 9.7
22 lactic acidosis 9.7
23 dystonia 9.7
24 intracranial hypertension 9.7
25 wallerian degeneration 9.7
26 myoclonus 9.7
27 syncope 9.7
28 dysphagia 9.7
29 large intestine cancer 9.6 CASP3 CASP9 IGF1 PTK2
30 ewing sarcoma 9.6 CASP3 CASP9 IGF1 PTK2
31 breast cancer 9.2 BCAR1 CASP3 CASP9 FOS IGF1 ITGB1

Graphical network of the top 20 diseases related to Cerebral Hypoxia:



Diseases related to Cerebral Hypoxia

Symptoms & Phenotypes for Cerebral Hypoxia

GenomeRNAi Phenotypes related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.92 CASP3 IGF1 PTK2
2 Decreased viability with paclitaxel GR00179-A-2 8.92 IGF1

MGI Mouse Phenotypes related to Cerebral Hypoxia:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.31 BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
2 growth/size/body region MP:0005378 10.26 BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
3 endocrine/exocrine gland MP:0005379 10.24 CAMK4 CASP3 CASP9 CREB1 FOS IGF1
4 cardiovascular system MP:0005385 10.23 BCAR1 CASP3 CASP9 CREB1 IGF1 ITGAV
5 mortality/aging MP:0010768 10.17 BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
6 hematopoietic system MP:0005397 10.16 CAMK4 CASP3 CASP9 FOS IGF1 ITGAV
7 homeostasis/metabolism MP:0005376 10.15 CAMK4 CASP3 CREB1 FOS IGF1 ITGAV
8 immune system MP:0005387 10.13 CAMK4 CASP3 CASP9 FOS IGF1 ITGAV
9 embryo MP:0005380 10.09 BCAR1 CASP9 CREB1 FOS ITGAV ITGB1
10 nervous system MP:0003631 10.02 CAMK4 CASP3 CASP9 CREB1 FOS IGF1
11 muscle MP:0005369 10.01 BCAR1 CASP3 CREB1 IGF1 ITGAV ITGB1
12 craniofacial MP:0005382 9.96 CASP3 CASP9 FOS ITGAV ITGB1
13 integument MP:0010771 9.93 CAMK4 CASP3 FOS IGF1 ITGB1 PTK2
14 normal MP:0002873 9.8 CAMK4 CREB1 FOS IGF1 ITGB1 NOS1
15 neoplasm MP:0002006 9.77 FOS IGF1 ITGAV ITGB1 PTK2
16 reproductive system MP:0005389 9.76 CAMK4 CASP3 CREB1 FOS IGF1 ITGB1
17 respiratory system MP:0005388 9.5 CASP3 CASP9 CREB1 IGF1 ITGB1 NOS1
18 skeleton MP:0005390 9.17 CAMK4 CASP3 CREB1 FOS IGF1 ITGB1

Drugs & Therapeutics for Cerebral Hypoxia

Drugs for Cerebral Hypoxia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
4
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
5
Racepinephrine Approved Phase 4 329-65-7 838
6 Anesthetics, Intravenous Phase 4
7 Anesthetics Phase 4,Phase 2,Not Applicable
8 Hypnotics and Sedatives Phase 4
9 Anesthetics, Inhalation Phase 4,Phase 2
10 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
11 Anesthetics, General Phase 4,Phase 2
12 Platelet Aggregation Inhibitors Phase 4
13 Ether Phase 4
14 Epinephryl borate Phase 4
15
Mannitol Approved, Investigational Phase 3 69-65-8 453 6251
16 Natriuretic Agents Phase 3,Not Applicable
17 diuretics Phase 3,Not Applicable
18 Xenon Phase 2
19
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
20 tannic acid Approved Not Applicable
21
Temozolomide Approved, Investigational 85622-93-1 5394
22
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
23
Furosemide Approved, Vet_approved Not Applicable 54-31-9 3440
24
Indapamide Approved Not Applicable 26807-65-8 3702
25
Spironolactone Approved Not Applicable 52-01-7, 1952-01-7 5833
26
Glutamic Acid Approved, Nutraceutical Not Applicable 56-86-0 33032
27 Neurotransmitter Agents Not Applicable
28 Psychotropic Drugs Not Applicable
29 Tranquilizing Agents Not Applicable
30 Dopamine agonists Not Applicable
31 Antipsychotic Agents Not Applicable
32 Dopamine Agents Not Applicable
33 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol Not Applicable
34 Hormones Not Applicable
35 Diuretics, Potassium Sparing Not Applicable
36 Mineralocorticoids Not Applicable
37 Sodium Potassium Chloride Symporter Inhibitors Not Applicable
38 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
39 Mineralocorticoid Receptor Antagonists Not Applicable
40 Hormone Antagonists Not Applicable

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Sevoflurane Decreases the Risk of Postoperative Delirium After Cerebral Hypoxemia During Surgery Unknown status NCT02133638 Phase 4 Sevoflurane;Propofol
2 Sodium Bicarbonate in Cardiopulmonary Resuscitation Unknown status NCT01377337 Phase 4 sodium bicarbonate
3 Hypertonic Saline vs. Mannitol for Elevated Intercranial Pressure Terminated NCT01111682 Phase 3 Mannitol;Hypertonic Saline
4 Effect of Xenon and Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest Patients Completed NCT00879892 Phase 2 xenon
5 Home Stimulation for Brain-Asphyxiated Infants Completed NCT00006516 Phase 2
6 CO2 (Carbon Dioxide) - Cerebral Oxygenation Recruiting NCT03338907 Phase 2 Oxycarbon (5% CO2+ 95% O2)
7 The Effects of Hypobaria vs Hypoxia on Cerebral Functions. Completed NCT03303118 Not Applicable
8 Feasibility Trial to Maintain Normal Cerebral Oxygen Saturation in High-Risk Cardiac Surgery Completed NCT01432184 Not Applicable
9 The Difference in Cerebral Oxygenation Between Propofol and Sevoflurane Completed NCT01757561
10 The Impact of a Beach Chair Position During Shoulder Arthroscopy on Regional Cerebral Oxygen Saturation : Comparison of Interscalene Block and General Anesthesia Completed NCT02605005
11 Cerebral Responses During Exercise in Hypoxia Completed NCT01614119 Not Applicable
12 Magnetic Resonance Biomarkers in Neonatal Encephalopathy Completed NCT01309711
13 Septic Shock and Delirium Because of rSO2 Abnormalities in Intensive Care Unit Patients (The SAD BRAIN Study) Completed NCT01836302
14 Near INfrared Spectroscopy in Aortic valvE ReplacemenT Completed NCT01251328 Not Applicable
15 CRRT for Glutamate Elimination After Cardiac Arrest Completed NCT02963298 Not Applicable
16 Retrospective Evaluation of Melanocortin Receptor 4 Polymorphisms in Patients With GBM Treated With Radiochemotherapy Completed NCT02458508
17 Observational Study in Preterm Infants With Intracranial Hemorrhage Recruiting NCT01620203
18 Correlating Brain Tissue Oxygen and Regional Cerebral Oximetry Recruiting NCT03128957 Not Applicable
19 Impact of Early Optimization of Brain Oxygenation on Neurological Outcome After Severe Traumatic Brain Injury Recruiting NCT02754063 Not Applicable
20 Lactate Therapy After Traumatic Brain Injury Recruiting NCT01573507 Not Applicable
21 Role of Active Deresuscitation After Resuscitation-2 Recruiting NCT03512392 Not Applicable
22 Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia Active, not recruiting NCT02482571 Not Applicable
23 Safeguarding the Brain of Our Smallest Infants Phase III Not yet recruiting NCT03770741 Not Applicable
24 Brain Oxygen Optimization in Severe TBI, Phase 3 Not yet recruiting NCT03754114 Not Applicable
25 A Prospective Study With a New Device for the Monitoring of Cerebral Oxygenation on Cardiac Surgery Patients Terminated NCT00598936
26 Continuous Neurophysiological Monitoring Detection of Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage Subjects Terminated NCT01343537 Early Phase 1

Search NIH Clinical Center for Cerebral Hypoxia

Genetic Tests for Cerebral Hypoxia

Anatomical Context for Cerebral Hypoxia

MalaCards organs/tissues related to Cerebral Hypoxia:

41
Brain, Cortex, Kidney, Endothelial, Lung, Spleen, Breast

Publications for Cerebral Hypoxia

Articles related to Cerebral Hypoxia:

(show top 50) (show all 357)
# Title Authors Year
1
Nocturnal cerebral hypoxia in obstructive sleep apnoea: a randomised controlled trial. ( 29700104 )
2018
2
Yap-Hippo pathway regulates cerebral hypoxia-reoxygenation injury in neuroblastoma N2a cells via inhibiting ROCK1/F-actin/mitochondrial fission pathways. ( 29796942 )
2018
3
Neuronal nitric oxide synthase inhibition reduces brain damage by promoting collateral recruitment in a cerebral hypoxia-ischemia mice model. ( 29863262 )
2018
4
Ameliorative Effect of Trans-Sinapic Acid and its Protective Role in Cerebral Hypoxia in Aluminium Chloride Induced Dementia of Alzheimer's Type. ( 29521253 )
2018
5
Noninvasive detection of acute cerebral hypoxia and subsequent matrix-metalloproteinase activity in a mouse model of cerebral ischemia using multispectral-optoacoustic-tomography. ( 29531962 )
2018
6
Magnesium sulphate induces preconditioning in preterm rodent models of cerebral hypoxia-ischemia. ( 29355709 )
2018
7
Dynamic TSPO-PET for assessing early effects of cerebral hypoxia and resuscitation in new born pigs. ( 30257223 )
2018
8
Comment on "Neuronal nitric oxide synthase inhibition reduces brain damage by promoting collateral recruitment" in a cerebral hypoxia-ischemia mice model. ( 30402827 )
2018
9
Dysphagia in cerebral hypoxia. ( 30412510 )
2018
10
Fentanyl-Induced Brain Hypoxia Triggers Brain Hyperglycemia and Biphasic Changes in Brain Temperature. ( 28849778 )
2018
11
Detection of Brain Hypoxia Based on Noninvasive Optical Monitoring of Cerebral Blood Flow with Diffuse Correlation Spectroscopy. ( 30030667 )
2018
12
Pathophysiology and Management of Intracranial Hypertension and Tissular Brain Hypoxia After Severe Traumatic Brain Injury: An Integrative Approach. ( 29502711 )
2018
13
Brain Oxygenation Optimization After Severe Traumatic Brain Injury: An Ode to Preventing Brain Hypoxia. ( 29538135 )
2018
14
NMNAT3 is protective against the effects of neonatal cerebral hypoxia-ischemia. ( 29046881 )
2017
15
Cerebral Hypoxia Caused by Flow Confliction During Minimally Invasive Cardiac Surgery With Retrograde Perfusion: A Word of Caution. ( 29126685 )
2017
16
Effect of Intranasally Delivered rh-VEGF165 on Angiogenesis Following Cerebral Hypoxia-Ischemia in the Cerebral Cortex of Newborn Piglets. ( 29112164 )
2017
17
The relationship between the Trendelenburg position and cerebral hypoxia inpatients who have undergone robot-assisted hysterectomy and prostatectomy ( 29306241 )
2017
18
The role of SUMOylation in cerebral hypoxia and ischemia. ( 28323006 )
2017
19
Persistent generalized periodic discharges: A specific marker of fatal outcome in cerebral hypoxia. ( 27894023 )
2017
20
Cerebral hypoxia during immediate transition after birth and short term neurological outcome. ( 28472725 )
2017
21
Effect of Src Kinase inhibition on Cytochrome c, Smac/DIABLO and Apoptosis Inducing Factor (AIF) Following Cerebral Hypoxia-Ischemia in Newborn Piglets. ( 29192254 )
2017
22
Preceding functional tooth loss delays recovery from acute cerebral hypoxia and locomotor hypoactivity after murine subarachnoid haemorrhage. ( 29044603 )
2017
23
Quantifying cerebral hypoxia by near-infrared spectroscopy tissue oximetry: the role of arterial-to-venous blood volume ratio. ( 28152128 )
2017
24
Administration of Huperzia quadrifariata Extract, a Cholinesterase Inhibitory Alkaloid Mixture, has Neuroprotective Effects in a Rat Model of Cerebral Hypoxia-Ischemia. ( 27885575 )
2017
25
Tetrahydrobiopterin in antenatal brain hypoxia-ischemia-induced motor impairments and cerebral palsy. ( 28803128 )
2017
26
Intravenous Heroin Induces Rapid Brain Hypoxia and Hyperglycemia that Precede Brain Metabolic Response. ( 28593192 )
2017
27
Sex-dependent consequences of neonatal brain hypoxia-ischemia in the rat. ( 27870406 )
2017
28
Mitochondria in brain hypoxia. ( 28258672 )
2017
29
Proteomic Analysis of Mouse Cortex Postsynaptic Density following Neonatal Brain Hypoxia-Ischemia. ( 28315865 )
2017
30
Brain hypoxia mapping in acute stroke: Back-to-back T2' MR versus 18F-fluoromisonidazole PET in rodents. ( 28523963 )
2017
31
Effects of Src Kinase Inhibition on Expression of Protein Tyrosine Phosphatase 1B after Brain Hypoxia in a Piglet Animal Model. ( 28626342 )
2017
32
Effects of Src kinase inhibition on expression of pro-caspase-2 after brain hypoxia in a piglet animal model. ( 28658050 )
2017
33
Transcranial Cerebral Oxymetric Monitoring Reduces Brain Hypoxia in Obese and Elderly Patients Undergoing General Anesthesia for Laparoscopic Cholecystectomy. ( 28708768 )
2017
34
Heroin Contaminated with Fentanyl Dramatically Enhances Brain Hypoxia and Induces Brain Hypothermia. ( 29085909 )
2017
35
The SafeBoosC II randomized trial: treatment guided by near-infrared spectroscopy reduces cerebral hypoxia without changing early biomarkers of brain injury. ( 26679155 )
2016
36
Application of a novel rectal cooling device in hypothermia therapy after cerebral hypoxia-ischemia in rats. ( 27613331 )
2016
37
Cerebral hypoxia/ischemia selectively disrupts tight junctions complexes in stem cell-derived human brain microvascular endothelial cells. ( 27724968 )
2016
38
Translational challenge models in support of efficacy studies: effect of cerebral hypoxia on cognitive performances in rodents. ( 27189464 )
2016
39
Does cerebral hypoxia facilitate central fatigue? ( 26891346 )
2016
40
Brain hypoxia before surgery; a tale of two cells: Astrocytes and oligodendrocytes. ( 26463653 )
2016
41
Isoflurane postconditioning induces concentration- and timing-dependent neuroprotection partly mediated by the GluR2 AMPA receptor in neonatal rats after brain hypoxia-ischemia. ( 26810756 )
2016
42
Dexmedetomidine Postconditioning Reduces Brain Injury after Brain Hypoxia-Ischemia in Neonatal Rats. ( 26932203 )
2016
43
Serum potassium concentration predicts brain hypoxia on CT after avalanche-induced cardiac arrest. ( 26935228 )
2016
44
Brain hypoxia is exacerbated in hypobaria during aeromedical evacuation in swine with traumatic brain injury. ( 26998778 )
2016
45
Brain Hypoxia and Ischemia After Traumatic Brain Injury: Is Oxygen the Right Metabolic Target? ( 27019352 )
2016
46
Potassium as a potential predictive biomarker of brain hypoxia in avalanche victims: preanalytical recommendations. ( 27198903 )
2016
47
Astrocytes and Brain Hypoxia. ( 27343098 )
2016
48
DHA but Not EPA Emulsions Preserve Neurological and Mitochondrial Function after Brain Hypoxia-Ischemia in Neonatal Mice. ( 27513579 )
2016
49
Cardiac Arrest-Induced Global Brain Hypoxia-Ischemia during Development Affects Spontaneous Activity Organization in Rat Sensory and Motor Thalamocortical Circuits during Adulthood. ( 27610077 )
2016
50
Genetic deletion of neuronal pentraxin 1 expression prevents brain injury in a neonatal mouse model of cerebral hypoxia-ischemia. ( 25554688 )
2015

Variations for Cerebral Hypoxia

Expression for Cerebral Hypoxia

Search GEO for disease gene expression data for Cerebral Hypoxia.

Pathways for Cerebral Hypoxia

Pathways related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.09 BCAR1 CAMK4 CASP3 CASP9 CREB1 IGF1
2
Show member pathways
13.94 CAMK4 CASP3 CASP9 CREB1 FOS ITGAV
3
Show member pathways
13.8 CASP3 CASP9 CREB1 FOS IGF1 ITGAV
4
Show member pathways
13.77 BCAR1 CASP3 CASP9 CREB1 FOS IGF1
5
Show member pathways
13.65 BCAR1 CAMK4 CREB1 FOS IGF1 ITGAV
6
Show member pathways
13.35 BCAR1 CASP3 CREB1 FOS ITGAV ITGB1
7
Show member pathways
13.33 CASP3 CASP9 CREB1 FOS IGF1 ITGAV
8
Show member pathways
13.27 BCAR1 IGF1 ITGAV ITGB1 NOS1 PTK2
9
Show member pathways
13.24 CASP3 CASP9 FOS IGF1 PTK2
10
Show member pathways
13 BCAR1 CAMK4 CREB1 IGF1 ITGAV ITGB1
11
Show member pathways
12.99 BCAR1 CAMK4 CASP3 FOS IGF1 PTK2
12
Show member pathways
12.99 BCAR1 CASP3 CASP9 CREB1 FOS ITGAV
13
Show member pathways
12.96 FOS IGF1 ITGAV ITGB1 PTK2
14
Show member pathways
12.93 CASP3 CASP9 CREB1 IGF1 ITGAV ITGB1
15
Show member pathways
12.9 BCAR1 FOS ITGAV ITGB1 NOS1 PTK2
16
Show member pathways
12.88 BCAR1 FOS IGF1 ITGB1 PTK2
17
Show member pathways
12.87 BCAR1 FOS IGF1 ITGAV ITGB1 PTK2
18
Show member pathways
12.83 CASP3 CASP9 CREB1 FOS
19
Show member pathways
12.82 BCAR1 CAMK4 CASP3 CASP9 FOS IGF1
20
Show member pathways
12.81 CAMK4 CASP9 CREB1 IGF1 ITGAV ITGB1
21
Show member pathways
12.79 CAMK4 CREB1 FOS ITGAV ITGB1 PTK2
22
Show member pathways
12.77 CASP3 CASP9 FOS IGF1
23 12.76 CASP3 CASP9 FOS IGF1 ITGAV ITGB1
24
Show member pathways
12.73 CASP9 FOS IGF1 PTK2
25 12.73 CASP3 CASP9 FOS IGF1
26
Show member pathways
12.65 CASP3 CASP9 CREB1 FOS
27
Show member pathways
12.61 BCAR1 ITGAV ITGB1 PTK2
28 12.6 BCAR1 ITGAV ITGB1 PTK2
29
Show member pathways
12.59 CASP9 FOS ITGB1 NOS1 PTK2
30
Show member pathways
12.55 BCAR1 CASP9 IGF1 PTK2
31
Show member pathways
12.53 CAMK4 CASP3 CASP9 FOS PTK2
32
Show member pathways
12.52 CAMK4 CREB1 FOS NOS1
33
Show member pathways
12.5 BCAR1 CASP3 CASP9 FOS IGF1 ITGB1
34
Show member pathways
12.5 BCAR1 CASP3 CASP9 CREB1 FOS IGF1
35
Show member pathways
12.48 CASP3 CREB1 FOS ITGB1 PTK2
36
Show member pathways
12.48 BCAR1 CASP3 CASP9 CREB1 FOS ITGAV
37
Show member pathways
12.47 CAMK4 CASP3 CASP9 CREB1 FOS NOS1
38
Show member pathways
12.44 CASP3 CASP9 ITGAV ITGB1 PTK2
39
Show member pathways
12.4 CASP9 CREB1 FOS ITGAV PTK2
40
Show member pathways
12.39 CASP9 CREB1 FOS IGF1
41
Show member pathways
12.38 CASP3 CASP9 CREB1 IGF1
42
Show member pathways
12.38 BCAR1 FOS IGF1 ITGAV ITGB1
43
Show member pathways
12.32 ITGAV ITGB1 PTK2
44 12.3 CASP3 IGF1 ITGAV ITGB1 PTK2
45
Show member pathways
12.29 CAMK4 CREB1 IGF1
46
Show member pathways
12.29 CAMK4 CREB1 FOS
47
Show member pathways
12.26 CAMK4 CREB1 FOS
48
Show member pathways
12.26 CASP3 CASP9 FOS ITGB1
49
Show member pathways
12.22 CASP3 CREB1 FOS
50
Show member pathways
12.22 CASP3 CASP9 FOS

GO Terms for Cerebral Hypoxia

Cellular components related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lamellipodium GO:0030027 9.43 BCAR1 ITGB1 PTK2
2 dendritic spine GO:0043197 9.33 ITGB1 NOS1 PTK2
3 integrin complex GO:0008305 9.32 ITGAV ITGB1
4 focal adhesion GO:0005925 9.26 BCAR1 ITGAV ITGB1 PTK2
5 alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867 8.62 IGF1 ITGAV

Biological processes related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.92 IGF1 ITGAV ITGB1 PTK2
2 positive regulation of transcription, DNA-templated GO:0045893 9.88 CAMK4 CREB1 FOS IGF1 NOS1
3 extracellular matrix organization GO:0030198 9.81 ITGAV ITGB1 PTK2
4 cell migration GO:0016477 9.81 BCAR1 ITGAV ITGB1
5 positive regulation of apoptotic process GO:0043065 9.8 CASP3 CASP9 CREB1 ITGB1
6 aging GO:0007568 9.78 CASP9 CREB1 FOS
7 response to hypoxia GO:0001666 9.77 CASP3 CREB1 NOS1
8 positive regulation of cell migration GO:0030335 9.71 BCAR1 IGF1 ITGAV PTK2
9 response to organic cyclic compound GO:0014070 9.7 CASP3 CASP9 FOS
10 response to antibiotic GO:0046677 9.63 CASP3 CASP9
11 ERK1 and ERK2 cascade GO:0070371 9.62 IGF1 ITGAV
12 response to lipopolysaccharide GO:0032496 9.62 CASP3 CASP9 FOS NOS1
13 heterotypic cell-cell adhesion GO:0034113 9.61 ITGAV ITGB1
14 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.61 BCAR1 ITGAV PTK2
15 positive regulation of cardiac muscle hypertrophy GO:0010613 9.6 IGF1 PTK2
16 cell adhesion mediated by integrin GO:0033627 9.58 ITGAV ITGB1
17 positive regulation of osteoclast differentiation GO:0045672 9.58 CREB1 FOS
18 neurotrophin TRK receptor signaling pathway GO:0048011 9.57 BCAR1 CASP3
19 platelet formation GO:0030220 9.56 CASP3 CASP9
20 cell-substrate adhesion GO:0031589 9.55 ITGAV ITGB1
21 negative regulation of anoikis GO:2000811 9.54 ITGB1 PTK2
22 cellular response to hepatocyte growth factor stimulus GO:0035729 9.51 BCAR1 CREB1
23 response to cobalt ion GO:0032025 9.46 CASP3 CASP9
24 glial cell apoptotic process GO:0034349 9.37 CASP3 CASP9
25 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.33 CASP3 CASP9 ITGAV
26 leukocyte apoptotic process GO:0071887 9.26 CASP3 CASP9
27 transforming growth factor beta receptor signaling pathway GO:0007179 9.26 CREB1 FOS ITGB1 PTK2
28 integrin-mediated signaling pathway GO:0007229 8.92 BCAR1 ITGAV ITGB1 PTK2

Molecular functions related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.5 IGF1 ITGAV ITGB1
2 coreceptor activity GO:0015026 9.4 ITGAV ITGB1
3 fibronectin binding GO:0001968 9.37 ITGAV ITGB1
4 protease binding GO:0002020 9.33 CASP3 ITGAV ITGB1
5 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.26 CASP3 CASP9
6 cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097199 8.96 CASP3 CASP9
7 C-X3-C chemokine binding GO:0019960 8.62 ITGAV ITGB1

Sources for Cerebral Hypoxia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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