MCID: CRB090
MIFTS: 43

Cerebral Hypoxia

Categories: Neuronal diseases

Aliases & Classifications for Cerebral Hypoxia

MalaCards integrated aliases for Cerebral Hypoxia:

Name: Cerebral Hypoxia 53 54
Brain Hypoxia 71

Classifications:



External Ids:

UMLS 71 C1527348

Summaries for Cerebral Hypoxia

NINDS : 53 Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.  In brain death, there is no measurable activity in the brain, although cardiovascular function is preserved. Life support is required for respiration.

MalaCards based summary : Cerebral Hypoxia, also known as brain hypoxia, is related to brain injury and traumatic brain injury. An important gene associated with Cerebral Hypoxia is CAMK4 (Calcium/Calmodulin Dependent Protein Kinase IV), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Sevoflurane and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart, and related phenotypes are Increased viability with paclitaxel and cellular

Wikipedia : 74 Cerebral hypoxia is a form of hypoxia (reduced supply of oxygen), specifically involving the brain; when... more...

Related Diseases for Cerebral Hypoxia

Diseases related to Cerebral Hypoxia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 brain injury 30.0 IGF1 CASP3
2 traumatic brain injury 29.8 IGF1 CASP3
3 ocular dominance 29.3 NOS1 CREB1
4 neuroblastoma 27.2 PTK2 ITGB1 IGF1 FOS CREB1 CASP9
5 hypoxia 11.9
6 anoxia 11.8
7 ischemia 10.6
8 carotid artery occlusion 10.3
9 cardiac arrest 10.2
10 encephalopathy 10.1
11 neonatal hypoxic and ischemic brain injury 10.1
12 retrograde amnesia 10.0 FOS CREB1
13 ocular motor apraxia 10.0
14 cerebral artery occlusion 10.0
15 respiratory failure 10.0
16 cerebrovascular disease 10.0
17 intracranial hypertension 10.0
18 myoclonus 10.0
19 cerebral palsy 9.9
20 opiate dependence 9.9 IGF1 FOS CREB1
21 amelogenesis imperfecta, type ig 9.9 IGF1 FOS CREB1
22 teeth hard tissue disease 9.9 IGF1 FOS CREB1
23 morphine dependence 9.9 FOS CREB1
24 stroke, ischemic 9.8
25 visual epilepsy 9.8
26 status epilepticus 9.8
27 dystonia 9.8
28 cerebral atrophy 9.8
29 seizure disorder 9.8
30 posttransplant acute limbic encephalitis 9.8
31 occlusion precerebral artery 9.8 FOS CASP3
32 cardiomyopathy, familial hypertrophic, 25 9.8 FOS CASP3
33 atherosclerosis susceptibility 9.7
34 migraine with or without aura 1 9.7
35 triiodothyronine receptor auxiliary protein 9.7
36 moyamoya disease 1 9.7
37 sudden infant death syndrome 9.7
38 body mass index quantitative trait locus 11 9.7
39 yemenite deaf-blind hypopigmentation syndrome 9.7
40 body mass index quantitative trait locus 9 9.7
41 body mass index quantitative trait locus 8 9.7
42 body mass index quantitative trait locus 4 9.7
43 body mass index quantitative trait locus 10 9.7
44 body mass index quantitative trait locus 7 9.7
45 diabetes mellitus, ketosis-prone 9.7
46 body mass index quantitative trait locus 12 9.7
47 body mass index quantitative trait locus 14 9.7
48 body mass index quantitative trait locus 18 9.7
49 chorea, childhood-onset, with psychomotor retardation 9.7
50 body mass index quantitative trait locus 19 9.7

Graphical network of the top 20 diseases related to Cerebral Hypoxia:



Diseases related to Cerebral Hypoxia

Symptoms & Phenotypes for Cerebral Hypoxia

GenomeRNAi Phenotypes related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with paclitaxel GR00179-A-1 8.32 CASP3

MGI Mouse Phenotypes related to Cerebral Hypoxia:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.29 BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
2 growth/size/body region MP:0005378 10.25 BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
3 endocrine/exocrine gland MP:0005379 10.22 CAMK4 CASP3 CASP9 CREB1 FOS IGF1
4 cardiovascular system MP:0005385 10.21 BCAR1 CASP3 CASP9 CREB1 IGF1 ITGAV
5 mortality/aging MP:0010768 10.17 BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
6 hematopoietic system MP:0005397 10.15 CAMK4 CASP3 CASP9 FOS IGF1 ITGAV
7 homeostasis/metabolism MP:0005376 10.13 CAMK4 CASP3 CREB1 FOS IGF1 ITGAV
8 immune system MP:0005387 10.11 CAMK4 CASP3 CASP9 FOS IGF1 ITGAV
9 embryo MP:0005380 10.08 BCAR1 CASP9 CREB1 FOS ITGAV ITGB1
10 nervous system MP:0003631 10.02 CAMK4 CASP3 CASP9 CREB1 FOS IGF1
11 muscle MP:0005369 10.01 BCAR1 CASP3 CREB1 IGF1 ITGAV ITGB1
12 normal MP:0002873 9.8 CAMK4 CREB1 FOS IGF1 ITGB1 NOS1
13 neoplasm MP:0002006 9.77 FOS IGF1 ITGAV ITGB1 PTK2
14 reproductive system MP:0005389 9.76 CAMK4 CASP3 CREB1 FOS IGF1 ITGB1
15 respiratory system MP:0005388 9.5 CASP3 CASP9 CREB1 IGF1 ITGB1 NOS1
16 skeleton MP:0005390 9.17 CAMK4 CASP3 CREB1 FOS IGF1 ITGB1

Drugs & Therapeutics for Cerebral Hypoxia

Drugs for Cerebral Hypoxia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
3
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
4
Racepinephrine Approved Phase 4 329-65-7 838
5 Anesthetics, Intravenous Phase 4
6 Ether Phase 4
7 Epinephryl borate Phase 4
8
Mannitol Approved, Investigational Phase 3 69-65-8 6251 453
9
Allopurinol Approved Phase 3 315-30-0 2094
10
Creatine Approved, Investigational, Nutraceutical Phase 3 57-00-1 586
11 Antioxidants Phase 3
12 Protective Agents Phase 3
13 Antirheumatic Agents Phase 3
14 diuretics Phase 3
15 Antimetabolites Phase 3
16
Clonidine Approved Phase 1, Phase 2 4205-90-7 2803
17 Xenon Experimental Phase 2 7440-63-3
18 Anesthetics, General Phase 2
19 Anesthetics, Inhalation Phase 2
20 Neurotransmitter Agents Phase 1, Phase 2
21 Antihypertensive Agents Phase 1, Phase 2
22 Analgesics Phase 1, Phase 2
23 Adrenergic alpha-Agonists Phase 1, Phase 2
24 Adrenergic Agents Phase 1, Phase 2
25 Sympatholytics Phase 1, Phase 2
26 Adrenergic Agonists Phase 1, Phase 2
27
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
28
Remifentanil Approved 132875-61-7 60815
29
Nitroglycerin Approved, Investigational 55-63-0 4510
30
Glycerol Approved, Investigational 56-81-5 753
31
Desflurane Approved 57041-67-5 42113
32
Temozolomide Approved, Investigational 85622-93-1 5394
33
Dexmedetomidine Approved, Vet_approved 113775-47-6 5311068 68602
34
Dopamine Approved 51-61-6, 62-31-7 681
35
Alprostadil Approved, Investigational 745-65-3 149351 5280723
36
tannic acid Approved 1401-55-4
37
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
38
Glutamic acid Approved, Nutraceutical 56-86-0 33032
39
Vitamin A Approved, Nutraceutical, Vet_approved 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
40
Cysteine Approved, Nutraceutical 52-90-4 5862
41
Resveratrol Investigational 501-36-0 445154
42 Platelet Aggregation Inhibitors
43 Pharmaceutical Solutions
44 Analgesics, Non-Narcotic
45 Anti-Inflammatory Agents
46 Anti-Inflammatory Agents, Non-Steroidal
47 Antipyretics
48 Dopamine Agents
49 Dopamine agonists
50 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol

Interventional clinical trials:

(show top 50) (show all 66)
# Name Status NCT ID Phase Drugs
1 Sevoflurane-based Volatile Induction and Maintenance of Anaesthesia (VIMA) Strategy Decreases the Risk of Postoperative Delirium in Elderly Patients With Registered Cerebral Hypoxemia Episodes During General Surgery Unknown status NCT02133638 Phase 4 Sevoflurane;Propofol
2 Does the Early Use of Sodium Bicarbonate Improve Results of Cardiopulmonary Resuscitation Following Out-of-Hospital Cardiac Arrest - a Prospective, Controlled Clinical Trial Unknown status NCT01377337 Phase 4 sodium bicarbonate
3 Hyperoxia: An Unrecognized Mechanism for Inducing "Hypoxia-Like" Symptoms Completed NCT03268590 Phase 4 Oxygen
4 Multicenter Double-blind Placebo-controlled Parallel-group Randomized Clinical Trial of Efficacy and Safety of Tenoten for Children Liquid Dosage Form Therapy in Infants With Sequelae of Perinatal Brain Injury Completed NCT03159611 Phase 3 Tenoten for children;Placebo
5 Randomized Controlled Trial of Hypothermia for Hypoxic-Ischemic Encephalopathy in Term Infants Completed NCT00005772 Phase 3
6 Evaluation of Systemic Hypothermia Initiated After 6 Hours of Age in Infants ≥36 Weeks Gestation With Hypoxic-Ischemic Encephalopathy: A Bayesian Evaluation. A Protocol for the NICHD Neonatal Research Network Completed NCT00614744 Phase 2, Phase 3
7 Creatine as a New Treatment for Schizophrenia:A Double-Blind Trial Completed NCT00140192 Phase 3 creatine
8 Effect of ALlopurinol in Addition to Hypothermia for Hypoxic-ischemic Brain Injury on Neurocognitive Outcome - a Blinded Randomized Placebo-controlled Parallel Group Multicenter Trial for Superiority (Phase III) Recruiting NCT03162653 Phase 3 Allopurinol;Mannitol
9 A Randomized Trial of Targeted Temperature Management With Whole Body Hypothermia For Moderate And Severe Hypoxic-Ischemic Encephalopathy In Premature Infants 33-35 Weeks Gestational Age. Recruiting NCT01793129 Phase 2, Phase 3
10 Optimizing Cooling Strategies at < 6 Hours of Age for Neonatal Hypoxic-Ischemic Encephalopathy Terminated NCT01192776 Phase 3
11 Neuroplasticity of Brain-Asphyxiated Infants: Efficacy of Intervention Completed NCT00006516 Phase 2
12 Anesthesia vs Aviation: Does Added Carbon Dioxide in Normobaric Hypoxia Have the Same Effect on Cerebral Oxygenation as in Hypobaric Hypoxia? Completed NCT03338907 Phase 2 Oxycarbon (5% CO2+ 95% O2)
13 Phase 2 Study of Effect of Xenon, in Combination With Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest Patients Completed NCT00879892 Phase 2 xenon
14 Phase I-II Clinical Trial to Determine the Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia Completed NCT01862250 Phase 1, Phase 2 Clonidine (Duraclon®)
15 Role of Cerebral Blood Flow on Ventilatory Stability During Sleep in Normoxia and Intermittent Hypoxia Not yet recruiting NCT03255408 Phase 1, Phase 2 Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep;Drug Lowering CBF and Intermittent Hypoxia Sleep;Placebo and Normoxia Sleep;Placebo and Intermittent Hypoxia Sleep
16 Neuroprotective Role of Lactate Therapy in Humans With Traumatic Brain Injury Unknown status NCT01573507
17 The Difference in Cerebral Oxygenation Between Propofol and Sevoflurane Completed NCT01757561
18 Perioperative Interventions to Optimize Cerebral Oxygen Saturation (rSO2) in High-risk Patients Undergoing Cardiac Surgery Should Have a Beneficial Systemic Effect for Enhancing Global Tissue Perfusion and Improve Outcomes. Completed NCT01432184
19 The Effects of Hypobaria vs Hypoxia on Cerebral Vasoreactivity, Brain's Electrical Activity and Concentration Performance on Pilots. Completed NCT03303118
20 Assessment of Tele-expertise for the Interpretation of MRI Among Neonates With High Risk of Neurological Sequelae Completed NCT03706651
21 Pilot Trial Concerning Glutamate Elimination With CRRT for Neurological Outcome After Cardiac Arrest Completed NCT02963298
22 Septic Shock and Delirium Because of rSO2 Abnormalities in Intensive Care Unit Patients (The SAD BRAIN Study) Completed NCT01836302
23 Near Infrared Spectroscopy in Aortic Valve Replacement Completed NCT01251328
24 The Impact of a Beach Chair Position During Shoulder Arthroscopy on Regional Cerebral Oxygen Saturation : Comparison of Interscalene Block and General Anesthesia Completed NCT02605005
25 Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia Completed NCT02482571
26 Oxygenation of the Neonatal Brain - a Study Using the INVOS Oximeter Completed NCT01690650 Oxygen
27 Oxygenation of the Neonatal Brain - a Study Using the INVOS Oximeter Completed NCT01684618
28 Assessment of Hypoxic Brain Injury by Analyzing Propofol-induced EEG Changes Completed NCT03485781
29 Effects of High Inspiratory Oxygen on Cerebral Tissue Oxygenation and Patient Recovery After Carotid Endarterectomy Completed NCT02991976
30 Postoperative Delirium in Patients Undergoing Hip Arthroplasty Completed NCT02323984
31 Effect of Hypotensive Anesthesia on Cerebral Perfusion and Blood Antioxidant Levels and HIF 1a Completed NCT04174417
32 A Multicentre Prospective Study on Magnetic Resonance Biomarkers in Neonatal Encephalopathy Completed NCT01309711
33 The Effects of Acute Trans-resveratrol Supplementation on Aspects of Cognitive Function and Cerebral Blood Flow, During Hypoxia and Normoxia, in Healthy, Young Humans. Completed NCT03100019 Placebo
34 Comparison of Low Versus Normal Flow Anesthesia on Cerebral Oxygenation and Bispectral Index in Morbidly Obese Patients Undergoing Sleeve Gastrectomy: Prospective, Randomized Clinical Trial Completed NCT03438734
35 Retrospective Evaluation of Prognostic and/or Predictive Profile of Melanocortin Receptor-4 Gene Polymorphisms in Patient With a Diagnosis of Glioblastoma Treated With Upfront Concomitant Radio-chemotherapy or Chemotherapy Completed NCT02458508
36 Evaluation of the Cerebral Responses to Exercise in Hypoxia Completed NCT01614119
37 Predicting Neurological Outcome Following Out of Hospital Cardiac Arrest (OHCA) by Quantitative Measurement of Serial Serum Biomarkers of Brain Injury. Completed NCT03112486
38 Brain-computer Interface in the Diagnosis of Disorders of Consciousness Completed NCT03998930
39 Hypoxia and Outcome Prediction in Early Stage Coma: Towards an Improvement of Clinical and Electrophysiological Predictors Completed NCT02231060
40 EARLY TRACHEOSTOMY VERSUS STANDARD OF CARE, A RANDOMIZED CONTROLLED CLINICAL TRIAL IN PATIENTS WITH SEVERE HEAD INJURY IN MULAGO HOSPITAL Completed NCT02442154
41 Optimizing Cerebral Oxygenation in Cardiac Surgery Completed NCT01539382
42 BiHiVE 2 Study. The Investigation and Validation of Predictive Biomarkers in Hypoxic-ischaemic Encephalopathy. Completed NCT02019147
43 Cardio-respiratory Events in VLBW Preterm Infants During the Transitional Period: Clinical Features and Impact of Neonatal Characteristics. Completed NCT04123691
44 Validation of the Predictive Value of the FORE-SIGHT™ Monitor for Early Detection of Hemodynamic Deterioration After Pediatric Cardiac Surgery. A Data-mining Study. Completed NCT01706497
45 Impact of Early Optimization of Brain Oxygenation on Neurological Outcome After Severe Traumatic Brain Injury Recruiting NCT02754063
46 Correlating Brain Tissue Oxygen Tension (PbrO2) and Regional Cerebral Oximetry (rSO2) in Normal Human Brain Under the Conditions of Changing Ventilation Strategy Recruiting NCT03128957
47 Cerebral Regional Tissue Oxygen Saturation to Guide Oxygen Delivery in Preterm Neonates During Immediate Transition After Birth: An Investigator-initiated Randomised Multi-centre Multinational Clinical Trial Recruiting NCT03166722
48 TAME Cardiac Arrest Trial: Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest: A Phase III Multi-Centre Randomised Controlled Trial Recruiting NCT03114033
49 Transfusion Strategies in Acute Brain Injured Patients. A Prospective Multicenter Randomized Study. Recruiting NCT02968654
50 Safety, Tolerability, and Early Efficacy of Immersive Virtual Reality for Early Neurocognitive Stimulation in the Intensive Care Unit. Recruiting NCT03569358

Search NIH Clinical Center for Cerebral Hypoxia

Genetic Tests for Cerebral Hypoxia

Anatomical Context for Cerebral Hypoxia

MalaCards organs/tissues related to Cerebral Hypoxia:

40
Brain, Cortex, Heart, Endothelial, Liver, Testes, Kidney

Publications for Cerebral Hypoxia

Articles related to Cerebral Hypoxia:

(show top 50) (show all 1697)
# Title Authors PMID Year
1
Effect of hypoxia on the expression of procaspase-9 and procaspase-3 in neuronal nuclear, mitochondrial and cytosolic fractions of the cerebral cortex of newborn piglets. 61 54
18468794 2008
2
ATP and cytochrome c-dependent activation of caspase-9 during hypoxia in the cerebral cortex of newborn piglets. 54 61
17976908 2007
3
Differential expression of apoptotic proteins following hypoxia-induced CREB phosphorylation in the cerebral cortex of newborn piglets. 61 54
17401658 2007
4
Mechanism of activation of caspase-9 and caspase-3 during hypoxia in the cerebral cortex of newborn piglets: the role of nuclear Ca2+ -influx. 54 61
17268855 2007
5
Hypoxia-induced Bax and Bcl-2 protein expression, caspase-9 activation, DNA fragmentation, and lipid peroxidation in mitochondria of the cerebral cortex of newborn piglets: the role of nitric oxide. 54 61
16777344 2006
6
Effect of 7-nitroindazole sodium on the cellular distribution of neuronal nitric oxide synthase in the cerebral cortex of hypoxic newborn piglets. 61 54
16804757 2006
7
Effect of neuronal nitric oxide synthase inhibition on caspase-9 activity during hypoxia in the cerebral cortex of newborn piglets. 54 61
16545906 2006
8
Anaemia and the brain. 61 54
17023891 2004
9
Effect of hypoxia on protein phosphatase 2A activity, subcellular distribution and expression in cerebral cortex of newborn piglets. 54 61
15262326 2004
10
Offspring of rats with cerebral hypoxia-ischemia manifest cognitive dysfunction in learning and memory abilities. 61
32209770 2020
11
Endogenous brain-sparing responses in brain pH and PO2 in a rodent model of birth asphyxia. 61
32174009 2020
12
Nitric oxide and the brain. Part 2: Effects following neonatal brain injury-friend or foe? 61
32563184 2020
13
Microglial-specific depletion of TAK1 is neuroprotective in the acute phase after ischemic stroke. 61
32382778 2020
14
Hypoxia-induced apoptosis of astrocytes is mediated by reduction of Dicer and activation of caspase-1. 61
32129540 2020
15
Genetically Encoded Tools for Research of Cell Signaling and Metabolism under Brain Hypoxia. 61
32545356 2020
16
Flavin Adenine Dinucleotide Fluorescence as an Early Marker of Mitochondrial Impairment During Brain Hypoxia. 61
32492921 2020
17
Nitric oxide and the brain. Part 1: Mechanisms of regulation, transport and effects on the developing brain. 61
32563183 2020
18
Hanging disguised as bondage: accidental or suicidal death? 61
32495262 2020
19
Protective effect of hydralazine on a cellular model of Parkinson's disease: a possible role of hypoxia-inducible factor (HIF)-1α. 61
31940231 2020
20
Changes in arginase isoforms in a murine model of neonatal brain hypoxia-ischemia. 61
32464635 2020
21
Metoprolol prevents neuronal dendrite remodeling in a canine model of chronic obstructive sleep apnea. 61
31863057 2020
22
Is jugular bulb oximetry monitoring associated with outcome in out of hospital cardiac arrest patients? 61
32435933 2020
23
Landmark clinical observations and immunopathogenesis pathways linked to HIV and Cryptococcus fatal central nervous system co-infection. 61
32472727 2020
24
A management algorithm for adult patients with both brain oxygen and intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC). 61
31965267 2020
25
Pharmacological HIF1 Inhibition Eliminates Downregulation of the Pentose Phosphate Pathway and Prevents Neuronal Apoptosis in Rat Hippocampus Caused by Severe Hypoxia. 61
31865524 2020
26
Determining the impacts of venoarterial extracorporeal membrane oxygenation on cerebral oxygenation using a one-dimensional blood flow simulator. 61
32220425 2020
27
Burden of hypoxia and intraventricular haemorrhage in extremely preterm infants. 61
31256012 2020
28
Neuroimaging provides relevant clinical information in patients with burn injuries. 61
31787472 2020
29
Defining a Time Window for Neuroprotection and Glia Modulation by Caffeine After Neonatal Hypoxia-Ischaemia. 61
31974940 2020
30
Clinical Usefulness of Transcranial Doppler as a Screening Tool for Early Cerebral Hypoxic Episodes in Patients with Moderate and Severe Traumatic Brain Injury. 61
31218643 2020
31
Comprehensive Functional Echocardiographic Assessment of Transposition of the Great Arteries: From Fetus to Newborn. 61
31919591 2020
32
Near-Infrared Spectroscopy Reveals Brain Hypoxia and Cerebrovascular Dysregulation in Primary Biliary Cholangitis. 61
31535726 2020
33
Maternal Undernourishment in Guinea Pigs Leads to Fetal Growth Restriction with Increased Hypoxic Cells and Oxidative Stress in the Brain. 61
32316015 2020
34
NIRS in the fetal to neonatal transition and immediate postnatal period. 61
32007425 2020
35
Brain Hypoxia Secondary to Diffusion Limitation in Hypoxic Ischemic Brain Injury Postcardiac Arrest. 61
31789834 2020
36
In a Rat Model of Opioid Maintenance, the G Protein-Biased Mu Opioid Receptor Agonist TRV130 Decreases Relapse to Oxycodone Seeking and Taking and Prevents Oxycodone-Induced Brain Hypoxia. 61
32305216 2020
37
Wheel running for 26 weeks is associated with sustained vascular plasticity in the rat motor cortex. 61
31870777 2020
38
A mathematical model of cerebral blood flow control in anaemia and hypoxia. 61
31823369 2020
39
Cerebral blood flow dynamic in foetuses with hypoplastic left heart syndrome: Incremental value of the first segment of the anterior cerebral artery over the middle cerebral artery? 61
31525274 2020
40
Neuroprotective effects of resveratrol against oxygen glucose deprivation induced mitochondrial dysfunction by activation of AMPK in SH-SY5Y cells with 3D gelatin scaffold. 61
31586626 2020
41
[APOΕ gene polymorphism and markers of brain damage in the outcomes of severe traumatic brain injury in children]. 61
32490622 2020
42
Neonatal cerebral hypoxia-ischemia in mice triggers age-dependent vascular effects and disabilities in adults; implication of tissue plasminogen activator (tPA). 61
31697944 2020
43
A New Rat Model of Chronic Cerebral Hypoperfusion Resulting in Early-Stage Vascular Cognitive Impairment. 61
32351379 2020
44
Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy. 61
31622925 2020
45
δ-Opioid Receptors, microRNAs, and Neuroinflammation in Cerebral Ischemia/Hypoxia. 61
32269564 2020
46
Multimodal monitoring to aid detection and management of intraoperative seizures: a case report. 61
31960222 2020
47
Superimposed Guillain-Barré Syndrome (GBS) in pediatric hypoxic brain injury. 61
32176662 2020
48
Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemia. 61
31941841 2020
49
The Role of Peripheral Opioid Receptors in Triggering Heroin-induced Brain Hypoxia. 61
31964994 2020
50
Aqueous extract of Dendrobium officinale confers neuroprotection against hypoxic-ischemic brain damage in neonatal rats. 61
31642199 2020

Variations for Cerebral Hypoxia

Expression for Cerebral Hypoxia

Search GEO for disease gene expression data for Cerebral Hypoxia.

Pathways for Cerebral Hypoxia

Pathways related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.08 PTK2 ITGB1 ITGAV IGF1 CREB1 CASP9
2
Show member pathways
13.94 PTK2 NOS1 ITGB1 ITGAV FOS CREB1
3
Show member pathways
13.77 PTK2 ITGB1 ITGAV IGF1 FOS CREB1
4
Show member pathways
13.73 PTK2 ITGB1 ITGAV IGF1 FOS CREB1
5
Show member pathways
13.63 PTK2 ITGB1 ITGAV IGF1 FOS CREB1
6
Show member pathways
13.36 PTK2 ITGB1 ITGAV FOS CREB1 CASP3
7
Show member pathways
13.33 PTK2 ITGB1 ITGAV IGF1 FOS CREB1
8
Show member pathways
13.27 PTK2 NOS1 ITGB1 ITGAV IGF1 BCAR1
9
Show member pathways
13.24 PTK2 IGF1 FOS CASP9 CASP3
10
Show member pathways
13.01 PTK2 ITGB1 ITGAV IGF1 CREB1 CAMK4
11
Show member pathways
12.96 PTK2 IGF1 FOS CASP3 CAMK4 BCAR1
12
Show member pathways
12.92 PTK2 ITGB1 ITGAV IGF1 CREB1 CASP9
13
Show member pathways
12.91 PTK2 ITGB1 IGF1 FOS CASP9 CASP3
14
Show member pathways
12.9 PTK2 NOS1 ITGB1 ITGAV FOS BCAR1
15
Show member pathways
12.88 PTK2 ITGB1 IGF1 FOS BCAR1
16
Show member pathways
12.87 PTK2 ITGB1 ITGAV IGF1 FOS BCAR1
17
Show member pathways
12.85 PTK2 ITGAV FOS CREB1 CASP9 CASP3
18
Show member pathways
12.79 PTK2 ITGB1 ITGAV FOS CREB1 CAMK4
19
Show member pathways
12.78 PTK2 ITGB1 ITGAV IGF1 CREB1 CASP9
20
Show member pathways
12.78 PTK2 NOS1 ITGB1 ITGAV FOS CREB1
21
Show member pathways
12.73 NOS1 FOS CREB1 CAMK4
22 12.73 PTK2 ITGB1 ITGAV IGF1 FOS CASP9
23 12.72 IGF1 FOS CASP9 CASP3
24
Show member pathways
12.67 IGF1 FOS CASP9 CASP3
25
Show member pathways
12.66 PTK2 IGF1 FOS CASP9 CAMK4
26
Show member pathways
12.63 PTK2 NOS1 IGF1 FOS CREB1 BCAR1
27 12.6 PTK2 ITGB1 ITGAV BCAR1
28
Show member pathways
12.58 PTK2 NOS1 ITGB1 FOS CASP9
29
Show member pathways
12.56 FOS CASP9 CASP3 BCAR1
30
Show member pathways
12.55 PTK2 IGF1 CASP9 BCAR1
31
Show member pathways
12.52 NOS1 FOS CREB1 CAMK4
32
Show member pathways
12.5 PTK2 ITGB1 IGF1 FOS CREB1 CASP9
33
Show member pathways
12.48 PTK2 ITGB1 FOS CREB1 CASP3
34
Show member pathways
12.44 PTK2 ITGB1 ITGAV CASP9 CASP3
35
Show member pathways
12.4 PTK2 ITGAV FOS CREB1 CASP9
36
Show member pathways
12.39 IGF1 FOS CREB1 CASP9
37
Show member pathways
12.38 IGF1 CREB1 CASP9 CASP3
38
Show member pathways
12.38 ITGB1 ITGAV IGF1 FOS BCAR1
39 12.31 PTK2 ITGB1 ITGAV IGF1 CASP3
40
Show member pathways
12.29 PTK2 ITGB1 FOS CREB1 CASP3
41
Show member pathways
12.28 IGF1 CREB1 CAMK4
42 12.27 ITGB1 FOS CASP9 CASP3
43
Show member pathways
12.27 PTK2 NOS1 ITGAV FOS CASP9 CASP3
44
Show member pathways
12.26 ITGB1 FOS CASP9 CASP3
45
Show member pathways
12.24 PTK2 ITGB1 ITGAV FOS CREB1 CASP9
46
Show member pathways
12.22 FOS CASP9 CASP3
47
Show member pathways
12.22 ITGB1 ITGAV IGF1
48 12.2 CREB1 CASP9 CASP3
49 12.19 PTK2 FOS CREB1 BCAR1
50
Show member pathways
12.19 PTK2 ITGB1 ITGAV CREB1 CASP9 CASP3

GO Terms for Cerebral Hypoxia

Cellular components related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lamellipodium GO:0030027 9.5 PTK2 ITGB1 BCAR1
2 focal adhesion GO:0005925 9.46 PTK2 ITGB1 ITGAV BCAR1
3 dendritic spine GO:0043197 9.43 PTK2 NOS1 ITGB1
4 integrin complex GO:0008305 9.37 ITGB1 ITGAV
5 cell junction GO:0030054 9.35 PTK2 NOS1 ITGB1 ITGAV BCAR1
6 alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867 8.62 ITGAV IGF1

Biological processes related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.92 PTK2 ITGB1 ITGAV IGF1
2 positive regulation of transcription, DNA-templated GO:0045893 9.88 NOS1 IGF1 FOS CREB1 CAMK4
3 positive regulation of apoptotic process GO:0043065 9.8 ITGB1 CREB1 CASP9 CASP3
4 aging GO:0007568 9.79 FOS CREB1 CASP9
5 response to hypoxia GO:0001666 9.78 NOS1 CREB1 CASP3
6 response to organic cyclic compound GO:0014070 9.7 FOS CASP9 CASP3
7 ERK1 and ERK2 cascade GO:0070371 9.64 ITGAV IGF1
8 response to antibiotic GO:0046677 9.63 CASP9 CASP3
9 heterotypic cell-cell adhesion GO:0034113 9.63 ITGB1 ITGAV
10 response to lipopolysaccharide GO:0032496 9.62 NOS1 FOS CASP9 CASP3
11 positive regulation of cardiac muscle hypertrophy GO:0010613 9.61 PTK2 IGF1
12 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.61 PTK2 ITGAV BCAR1
13 positive regulation of wound healing GO:0090303 9.6 PTK2 ITGB1
14 positive regulation of osteoclast differentiation GO:0045672 9.59 FOS CREB1
15 cell adhesion mediated by integrin GO:0033627 9.58 ITGB1 ITGAV
16 neurotrophin TRK receptor signaling pathway GO:0048011 9.58 CASP3 BCAR1
17 cell-substrate adhesion GO:0031589 9.57 ITGB1 ITGAV
18 platelet formation GO:0030220 9.56 CASP9 CASP3
19 negative regulation of anoikis GO:2000811 9.55 PTK2 ITGB1
20 cellular response to hepatocyte growth factor stimulus GO:0035729 9.54 CREB1 BCAR1
21 positive regulation of fibroblast migration GO:0010763 9.51 PTK2 ITGB1
22 response to cobalt ion GO:0032025 9.46 CASP9 CASP3
23 transforming growth factor beta receptor signaling pathway GO:0007179 9.46 PTK2 ITGB1 FOS CREB1
24 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.43 ITGAV CASP9 CASP3
25 leukocyte apoptotic process GO:0071887 9.4 CASP9 CASP3
26 glial cell apoptotic process GO:0034349 9.37 CASP9 CASP3
27 integrin-mediated signaling pathway GO:0007229 9.26 PTK2 ITGB1 ITGAV BCAR1
28 positive regulation of cell migration GO:0030335 9.02 PTK2 ITGB1 ITGAV IGF1 BCAR1

Molecular functions related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.43 ITGB1 ITGAV CASP3
2 fibronectin binding GO:0001968 9.4 ITGB1 ITGAV
3 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.37 CASP9 CASP3
4 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 9.32 CASP9 CASP3
5 cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097199 9.16 CASP9 CASP3
6 C-X3-C chemokine binding GO:0019960 8.96 ITGB1 ITGAV
7 integrin binding GO:0005178 8.92 PTK2 ITGB1 ITGAV IGF1

Sources for Cerebral Hypoxia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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