MCID: CRB090
MIFTS: 45

Cerebral Hypoxia

Categories: Neuronal diseases

Aliases & Classifications for Cerebral Hypoxia

MalaCards integrated aliases for Cerebral Hypoxia:

Name: Cerebral Hypoxia 54 55
Brain Hypoxia 72

Classifications:



External Ids:

UMLS 72 C1527348

Summaries for Cerebral Hypoxia

NINDS : 54 Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.  In brain death, there is no measurable activity in the brain, although cardiovascular function is preserved. Life support is required for respiration.

MalaCards based summary : Cerebral Hypoxia, also known as brain hypoxia, is related to traumatic brain injury and ocular dominance. An important gene associated with Cerebral Hypoxia is CAMK4 (Calcium/Calmodulin Dependent Protein Kinase IV), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Propofol and Sevoflurane have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

Wikipedia : 75 Cerebral hypoxia is a form of hypoxia (reduced supply of oxygen), specifically involving the brain; when... more...

Related Diseases for Cerebral Hypoxia

Diseases related to Cerebral Hypoxia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 traumatic brain injury 29.6 IGF1 CASP3
2 ocular dominance 28.9 NOS1 CREB1
3 hypoxia 11.9
4 anoxia 11.8
5 ischemia 10.5
6 carotid artery occlusion 10.3
7 cardiac arrest 10.2
8 brain injury 10.2
9 neonatal hypoxic and ischemic brain injury 10.1
10 encephalopathy 10.1
11 ocular motor apraxia 10.0
12 morphine dependence 10.0 FOS CREB1
13 cerebral artery occlusion 10.0
14 respiratory failure 10.0
15 cerebrovascular disease 10.0
16 intracranial hypertension 10.0
17 myoclonus 10.0
18 cerebral palsy 9.9
19 neuroblastoma 1 9.8
20 stroke, ischemic 9.8
21 hydrops, lactic acidosis, and sideroblastic anemia 9.8
22 visual epilepsy 9.8
23 status epilepticus 9.8
24 dystonia 9.8
25 seizure disorder 9.8
26 posttransplant acute limbic encephalitis 9.8
27 atherosclerosis susceptibility 9.7
28 migraine with or without aura 1 9.7
29 triiodothyronine receptor auxiliary protein 9.7
30 moyamoya disease 1 9.7
31 sudden infant death syndrome 9.7
32 body mass index quantitative trait locus 11 9.7
33 yemenite deaf-blind hypopigmentation syndrome 9.7
34 body mass index quantitative trait locus 9 9.7
35 body mass index quantitative trait locus 8 9.7
36 body mass index quantitative trait locus 4 9.7
37 body mass index quantitative trait locus 10 9.7
38 body mass index quantitative trait locus 7 9.7
39 diabetes mellitus, ketosis-prone 9.7
40 body mass index quantitative trait locus 12 9.7
41 body mass index quantitative trait locus 14 9.7
42 body mass index quantitative trait locus 18 9.7
43 chorea, childhood-onset, with psychomotor retardation 9.7
44 body mass index quantitative trait locus 19 9.7
45 body mass index quantitative trait locus 20 9.7
46 pulmonary hypertension 9.7
47 metabolic acidosis 9.7
48 focal dystonia 9.7
49 sleep apnea 9.7
50 post-cardiac arrest syndrome 9.7

Graphical network of the top 20 diseases related to Cerebral Hypoxia:



Diseases related to Cerebral Hypoxia

Symptoms & Phenotypes for Cerebral Hypoxia

GenomeRNAi Phenotypes related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.92 CASP3 IGF1 PTK2
2 Decreased viability with paclitaxel GR00179-A-2 8.92 IGF1

MGI Mouse Phenotypes related to Cerebral Hypoxia:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.31 BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
2 growth/size/body region MP:0005378 10.26 BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
3 endocrine/exocrine gland MP:0005379 10.24 CAMK4 CASP3 CASP9 CREB1 FOS IGF1
4 cardiovascular system MP:0005385 10.23 BCAR1 CASP3 CASP9 CREB1 IGF1 ITGAV
5 mortality/aging MP:0010768 10.17 BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
6 hematopoietic system MP:0005397 10.16 CAMK4 CASP3 CASP9 FOS IGF1 ITGAV
7 homeostasis/metabolism MP:0005376 10.15 CAMK4 CASP3 CREB1 FOS IGF1 ITGAV
8 immune system MP:0005387 10.13 CAMK4 CASP3 CASP9 FOS IGF1 ITGAV
9 embryo MP:0005380 10.09 BCAR1 CASP9 CREB1 FOS ITGAV ITGB1
10 nervous system MP:0003631 10.02 CAMK4 CASP3 CASP9 CREB1 FOS IGF1
11 muscle MP:0005369 10.01 BCAR1 CASP3 CREB1 IGF1 ITGAV ITGB1
12 craniofacial MP:0005382 9.96 CASP3 CASP9 FOS ITGAV ITGB1
13 integument MP:0010771 9.93 CAMK4 CASP3 FOS IGF1 ITGB1 PTK2
14 normal MP:0002873 9.8 CAMK4 CREB1 FOS IGF1 ITGB1 NOS1
15 neoplasm MP:0002006 9.77 FOS IGF1 ITGAV ITGB1 PTK2
16 reproductive system MP:0005389 9.76 CAMK4 CASP3 CREB1 FOS IGF1 ITGB1
17 respiratory system MP:0005388 9.5 CASP3 CASP9 CREB1 IGF1 ITGB1 NOS1
18 skeleton MP:0005390 9.17 CAMK4 CASP3 CREB1 FOS IGF1 ITGB1

Drugs & Therapeutics for Cerebral Hypoxia

Drugs for Cerebral Hypoxia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
2
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
3
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
4
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
5
Racepinephrine Approved Phase 4 329-65-7 838
6 Hypnotics and Sedatives Phase 4
7 Anesthetics, Intravenous Phase 4
8 Ether Phase 4
9 Epinephryl borate Phase 4
10
Mannitol Approved, Investigational Phase 3 69-65-8 453 6251
11
Allopurinol Approved Phase 3 315-30-0 2094
12
Creatine Approved, Investigational, Nutraceutical Phase 3 57-00-1 586
13 Antioxidants Phase 3
14 Protective Agents Phase 3
15 Antirheumatic Agents Phase 3
16 Free Radical Scavengers Phase 3
17 Natriuretic Agents Phase 3
18 diuretics Phase 3
19 Antimetabolites Phase 3
20
Clonidine Approved Phase 1, Phase 2 4205-90-7 2803
21 Xenon Experimental Phase 2 7440-63-3
22 Central Nervous System Depressants Phase 2
23 Anesthetics Phase 2
24 Anesthetics, General Phase 2
25 Anesthetics, Inhalation Phase 2
26 Neurotransmitter Agents Phase 1, Phase 2
27 Peripheral Nervous System Agents Phase 1, Phase 2
28 Analgesics Phase 1, Phase 2
29 Antihypertensive Agents Phase 1, Phase 2
30 Adrenergic alpha-2 Receptor Agonists Phase 1, Phase 2
31 Adrenergic Agonists Phase 1, Phase 2
32 Adrenergic alpha-Agonists Phase 1, Phase 2
33 Adrenergic Agents Phase 1, Phase 2
34 Sympatholytics Phase 1, Phase 2
35 Autonomic Agents Phase 1, Phase 2
36
tannic acid Approved 1401-55-4
37
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
38
Resveratrol Approved, Experimental, Investigational 501-36-0 445154
39
Desflurane Approved 57041-67-5 42113
40
Temozolomide Approved, Investigational 85622-93-1 5394
41
Dexmedetomidine Approved, Vet_approved 113775-47-6 68602 5311068
42
Dobutamine Approved 34368-04-2 36811
43
Dopamine Approved 51-61-6, 62-31-7 681
44
Alprostadil Approved, Investigational 745-65-3 5280723 149351
45
Glutamic acid Approved, Nutraceutical 56-86-0 33032
46
Vitamin A Approved, Nutraceutical, Vet_approved 22737-96-8, 11103-57-4, 68-26-8 9904001 445354
47 Platelet Aggregation Inhibitors
48 Analgesics, Non-Narcotic
49 Antineoplastic Agents, Phytogenic
50 Anti-Inflammatory Agents, Non-Steroidal

Interventional clinical trials:

(show top 50) (show all 58)
# Name Status NCT ID Phase Drugs
1 Sevoflurane-based Volatile Induction and Maintenance of Anaesthesia (VIMA) Strategy Decreases the Risk of Postoperative Delirium in Elderly Patients With Registered Cerebral Hypoxemia Episodes During General Surgery Unknown status NCT02133638 Phase 4 Sevoflurane;Propofol
2 Does the Early Use of Sodium Bicarbonate Improve Results of Cardiopulmonary Resuscitation Following Out-of-Hospital Cardiac Arrest - a Prospective, Controlled Clinical Trial Unknown status NCT01377337 Phase 4 sodium bicarbonate
3 Hyperoxia: An Unrecognized Mechanism for Inducing "Hypoxia-Like" Symptoms Completed NCT03268590 Phase 4 Oxygen
4 Multicenter Double-blind Placebo-controlled Parallel-group Randomized Clinical Trial of Efficacy and Safety of Tenoten for Children Liquid Dosage Form Therapy in Infants With Sequelae of Perinatal Brain Injury Completed NCT03159611 Phase 3 Tenoten for children;Placebo
5 Randomized Controlled Trial of Hypothermia for Hypoxic-Ischemic Encephalopathy in Term Infants Completed NCT00005772 Phase 3
6 Evaluation of Systemic Hypothermia Initiated After 6 Hours of Age in Infants ≥36 Weeks Gestation With Hypoxic-Ischemic Encephalopathy: A Bayesian Evaluation. A Protocol for the NICHD Neonatal Research Network Completed NCT00614744 Phase 2, Phase 3
7 Creatine as a New Treatment for Schizophrenia:A Double-Blind Trial Completed NCT00140192 Phase 3 creatine
8 A Randomized Trial of Targeted Temperature Management With Whole Body Hypothermia For Moderate And Severe Hypoxic-Ischemic Encephalopathy In Premature Infants 33-35 Weeks Gestational Age. Recruiting NCT01793129 Phase 2, Phase 3
9 Effect of ALlopurinol in Addition to Hypothermia for Hypoxic-ischemic Brain Injury on Neurocognitive Outcome - a Blinded Randomized Placebo-controlled Parallel Group Multicenter Trial for Superiority (Phase III) Recruiting NCT03162653 Phase 3 Allopurinol;Mannitol
10 Transfusion Strategies in Acute Brain Injured Patients. A Prospective Multicenter Randomized Study. Recruiting NCT02968654 Phase 3
11 Optimizing Cooling Strategies at < 6 Hours of Age for Neonatal Hypoxic-Ischemic Encephalopathy Terminated NCT01192776 Phase 3
12 Neuroplasticity of Brain-Asphyxiated Infants: Efficacy of Intervention Completed NCT00006516 Phase 2
13 Anesthesia vs Aviation: Does Added Carbon Dioxide in Normobaric Hypoxia Have the Same Effect on Cerebral Oxygenation as in Hypobaric Hypoxia? Completed NCT03338907 Phase 2 Oxycarbon (5% CO2+ 95% O2)
14 Phase 2 Study of Effect of Xenon, in Combination With Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest Patients Completed NCT00879892 Phase 2 xenon
15 Phase I-II Clinical Trial to Determine the Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia Completed NCT01862250 Phase 1, Phase 2 Clonidine (Duraclon®)
16 Role of Cerebral Blood Flow on Ventilatory Stability During Sleep in Normoxia and Intermittent Hypoxia Not yet recruiting NCT03255408 Phase 1, Phase 2 Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep;Drug Lowering CBF and Intermittent Hypoxia Sleep;Placebo and Normoxia Sleep;Placebo and Intermittent Hypoxia Sleep
17 The Difference in Cerebral Oxygenation Between Propofol and Sevoflurane Completed NCT01757561
18 Perioperative Interventions to Optimize Cerebral Oxygen Saturation (rSO2) in High-risk Patients Undergoing Cardiac Surgery Should Have a Beneficial Systemic Effect for Enhancing Global Tissue Perfusion and Improve Outcomes. Completed NCT01432184
19 The Effects of Hypobaria vs Hypoxia on Cerebral Vasoreactivity, Brain's Electrical Activity and Concentration Performance on Pilots. Completed NCT03303118
20 Assessment of Tele-expertise for the Interpretation of MRI Among Neonates With High Risk of Neurological Sequelae Completed NCT03706651
21 Pilot Trial Concerning Glutamate Elimination With CRRT for Neurological Outcome After Cardiac Arrest Completed NCT02963298
22 Septic Shock and Delirium Because of rSO2 Abnormalities in Intensive Care Unit Patients (The SAD BRAIN Study) Completed NCT01836302
23 Near Infrared Spectroscopy in Aortic Valve Replacement Completed NCT01251328
24 The Impact of a Beach Chair Position During Shoulder Arthroscopy on Regional Cerebral Oxygen Saturation : Comparison of Interscalene Block and General Anesthesia Completed NCT02605005
25 Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia Completed NCT02482571
26 Oxygenation of the Neonatal Brain - a Study Using the INVOS Oximeter Completed NCT01690650 Oxygen
27 Oxygenation of the Neonatal Brain - a Study Using the INVOS Oximeter Completed NCT01684618
28 Effects of High Inspiratory Oxygen on Cerebral Tissue Oxygenation and Patient Recovery After Carotid Endarterectomy Completed NCT02991976
29 Postoperative Delirium in Patients Undergoing Hip Arthroplasty Completed NCT02323984
30 A Multicentre Prospective Study on Magnetic Resonance Biomarkers in Neonatal Encephalopathy Completed NCT01309711
31 The Effects of Acute Trans-resveratrol Supplementation on Aspects of Cognitive Function and Cerebral Blood Flow, During Hypoxia and Normoxia, in Healthy, Young Humans. Completed NCT03100019 Placebo
32 Comparison of Low Versus Normal Flow Anesthesia on Cerebral Oxygenation and Bispectral Index in Morbidly Obese Patients Undergoing Sleeve Gastrectomy: Prospective, Randomized Clinical Trial Completed NCT03438734
33 Retrospective Evaluation of Prognostic and/or Predictive Profile of Melanocortin Receptor-4 Gene Polymorphisms in Patient With a Diagnosis of Glioblastoma Treated With Upfront Concomitant Radio-chemotherapy or Chemotherapy Completed NCT02458508
34 Evaluation of the Cerebral Responses to Exercise in Hypoxia Completed NCT01614119
35 Brain-computer Interface in the Diagnosis of Disorders of Consciousness Completed NCT03998930
36 EARLY TRACHEOSTOMY VERSUS STANDARD OF CARE, A RANDOMIZED CONTROLLED CLINICAL TRIAL IN PATIENTS WITH SEVERE HEAD INJURY IN MULAGO HOSPITAL Completed NCT02442154
37 Hypoxia and Outcome Prediction in Early Stage Coma: Towards an Improvement of Clinical and Electrophysiological Predictors Completed NCT02231060
38 Optimizing Cerebral Oxygenation in Cardiac Surgery Completed NCT01539382
39 BiHiVE 2 Study. The Investigation and Validation of Predictive Biomarkers in Hypoxic-ischaemic Encephalopathy. Completed NCT02019147
40 Validation of the Predictive Value of the FORE-SIGHT™ Monitor for Early Detection of Hemodynamic Deterioration After Pediatric Cardiac Surgery. A Data-mining Study. Completed NCT01706497
41 NeoAdapt 3: An Observational Study Investigating Novel Biomarkers in the Evaluation and Treatment of Neonatal Circulatory Insufficiency in Infants Suffering From Hypoxic Ischemic Encephalopathy. Completed NCT02051894 Dobutamine
42 Impact of Early Optimization of Brain Oxygenation on Neurological Outcome After Severe Traumatic Brain Injury Recruiting NCT02754063
43 Correlating Brain Tissue Oxygen Tension (PbrO2) and Regional Cerebral Oximetry (rSO2) in Normal Human Brain Under the Conditions of Changing Ventilation Strategy Recruiting NCT03128957
44 TAME Cardiac Arrest Trial: Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest: A Phase III Multi-Centre Randomised Controlled Trial Recruiting NCT03114033
45 Cerebral Regional Tissue Oxygen Saturation to Guide Oxygen Delivery in Preterm Neonates During Immediate Transition After Birth: An Investigator-initiated Randomised Multi-centre Multinational Clinical Trial Recruiting NCT03166722
46 Predicting Neurological Outcome Following Out of Hospital Cardiac Arrest (OHCA) by Quantitative Measurement of Serial Serum Biomarkers of Brain Injury. Recruiting NCT03112486
47 Neuroprotective Role of Lactate Therapy in Humans With Traumatic Brain Injury Recruiting NCT01573507
48 Safety, Tolerability, and Early Efficacy of Immersive Virtual Reality for Early Neurocognitive Stimulation in the Intensive Care Unit. Recruiting NCT03569358
49 Impact of Obstructive Sleep Apnea in the Evolution of Alzheimer Disease. Role of Hypoxia and Sleep Fragmentation Recruiting NCT02814045
50 Multimodal Monitoring of Hemodynamics in Extremely Low Birth Weight Preterm Infant in a Canadian Tertiary Level Unit- Non-Blinded Randomized Control Trial Recruiting NCT03841929

Search NIH Clinical Center for Cerebral Hypoxia

Genetic Tests for Cerebral Hypoxia

Anatomical Context for Cerebral Hypoxia

MalaCards organs/tissues related to Cerebral Hypoxia:

41
Brain, Cortex, Heart, Endothelial, Testes, Kidney, Cerebellum

Publications for Cerebral Hypoxia

Articles related to Cerebral Hypoxia:

(show top 50) (show all 1638)
# Title Authors PMID Year
1
Effect of hypoxia on the expression of procaspase-9 and procaspase-3 in neuronal nuclear, mitochondrial and cytosolic fractions of the cerebral cortex of newborn piglets. 9 38
18468794 2008
2
ATP and cytochrome c-dependent activation of caspase-9 during hypoxia in the cerebral cortex of newborn piglets. 9 38
17976908 2007
3
Differential expression of apoptotic proteins following hypoxia-induced CREB phosphorylation in the cerebral cortex of newborn piglets. 9 38
17401658 2007
4
Mechanism of activation of caspase-9 and caspase-3 during hypoxia in the cerebral cortex of newborn piglets: the role of nuclear Ca2+ -influx. 9 38
17268855 2007
5
Hypoxia-induced Bax and Bcl-2 protein expression, caspase-9 activation, DNA fragmentation, and lipid peroxidation in mitochondria of the cerebral cortex of newborn piglets: the role of nitric oxide. 9 38
16777344 2006
6
Effect of 7-nitroindazole sodium on the cellular distribution of neuronal nitric oxide synthase in the cerebral cortex of hypoxic newborn piglets. 9 38
16804757 2006
7
Effect of neuronal nitric oxide synthase inhibition on caspase-9 activity during hypoxia in the cerebral cortex of newborn piglets. 9 38
16545906 2006
8
Anaemia and the brain. 9 38
17023891 2004
9
Effect of hypoxia on protein phosphatase 2A activity, subcellular distribution and expression in cerebral cortex of newborn piglets. 9 38
15262326 2004
10
Effects of novel hexahydropyrimidine derivatives as potential ligands of M1 muscarinic acetylcholine receptor on cognitive function, hypoxia-induced lethality, and oxidative stress in rodents. 38
31340175 2019
11
Suppression of PDGF induces neuronal apoptosis after neonatal cerebral hypoxia and ischemia by inhibiting P-PI3K and P-AKT signaling pathways. 38
31082354 2019
12
Intra- and interdialytic cerebral hypoxia: A culprit of cognitive decline going unpunished? 38
31034688 2019
13
Effect of nitrite on the electroencephalographic activity in the healthy brain. 38
31254718 2019
14
Continuous EEG monitoring after brain tumor surgery. 38
31278599 2019
15
Redox-Dependent Loss of Flavin by Mitochondrial Complex I in Brain Ischemia/Reperfusion Injury. 38
31037949 2019
16
LncRNA-ROR is involved in cerebral hypoxia/reoxygenation-induced injury via regulating miR-135a-5p/ROCK1/2. 38
31419405 2019
17
A case report of unusual clinical features of a spontaneous coronary artery rupture: pathologic findings in the rupture site. 38
31384915 2019
18
In chronic hypoxia, glucose availability and hypoxic severity dictate the balance between HIF-1 and HIF-2 in astrocytes. 38
31298941 2019
19
Limitations of near infrared spectroscopy (NIRS) in neurosurgical setting: our case experience. 38
30315489 2019
20
The Burden of Brain Hypoxia and Optimal Mean Arterial Pressure in Patients With Hypoxic Ischemic Brain Injury After Cardiac Arrest. 38
30889022 2019
21
Conventional and functional magnetic resonance imaging features of late subacute cortical laminar necrosis in a dog. 38
31120629 2019
22
Nitric oxide donor molsidomine favors features of atherosclerotic plaque stability and reduces myocardial infarction in mice. 38
31085310 2019
23
Cerebral perfusion and assessing hemodynamic significance for patent ductus arteriosus using near infrared red spectroscopy in very low birth weight infants. 38
31303077 2019
24
FGF21 promotes functional recovery after hypoxic-ischemic brain injury in neonatal rats by activating the PI3K/Akt signaling pathway via FGFR1/β-klotho. 38
30802446 2019
25
Echinacoside Alleviates Hypoxic-Ischemic Brain Injury in Neonatal Rat by Enhancing Antioxidant Capacity and Inhibiting Apoptosis. 38
30911982 2019
26
Continuous Near-Infrared Spectroscopy Monitoring in Adult Traumatic Brain Injury: A Systematic Review. 38
31306264 2019
27
Angioneurins - Key regulators of blood-brain barrier integrity during hypoxic and ischemic brain injury. 38
30970273 2019
28
Exposure Duration and History of Hypertension Predicted Neurological Sequelae in Patients with Carbon Monoxide Poisoning. 38
31181009 2019
29
Impact of inflammation on brain subcellular energetics in anesthetized rats. 38
31307382 2019
30
Clinical Usefulness of Transcranial Doppler as a Screening Tool for Early Cerebral Hypoxic Episodes in Patients with Moderate and Severe Traumatic Brain Injury. 38
31218643 2019
31
Burden of hypoxia and intraventricular haemorrhage in extremely preterm infants. 38
31256012 2019
32
Factors responsible for cerebral hypoxia in hemodialysis population. 38
31177793 2019
33
Respiratory depression and brain hypoxia induced by opioid drugs: Morphine, oxycodone, heroin, and fentanyl. 38
30735692 2019
34
Interactions of benzodiazepines with heroin: Respiratory depression, temperature effects, and behavior. 38
31228487 2019
35
Thyroid Hormone Protects Primary Cortical Neurons Exposed to Hypoxia By Reducing DNA Methylation and Apoptosis. 38
31095291 2019
36
Brain wave disturbance and cognitive impairment after CPR. 38
31010488 2019
37
Validation of a Second-Generation Near-Infrared Spectroscopy Monitor in Children With Congenital Heart Disease. 38
29324491 2019
38
Thoracic endovascular aortic repair for the treatment of ruptured acute type B aortic dissection. 38
30712166 2019
39
Protective effect of troxerutin and cerebroprotein hydrolysate injection on cerebral ischemia through inhibition of oxidative stress and promotion of angiogenesis in rats. 38
30816516 2019
40
HIF1α Signaling in the Endogenous Protective Responses after Neonatal Brain Hypoxia-Ischemia. 38
30836371 2019
41
Hypoxia Induces Astrocyte-Derived Lipocalin-2 in Ischemic Stroke. 38
30871254 2019
42
Cerebral regional tissue Oxygen Saturation to Guide Oxygen Delivery in preterm neonates during immediate transition after birth (COSGOD III): an investigator-initiated, randomized, multi-center, multi-national, clinical trial on additional cerebral tissue oxygen saturation monitoring combined with defined treatment guidelines versus standard monitoring and treatment as usual in premature infants during immediate transition: study protocol for a randomized controlled trial. 38
30894226 2019
43
Oxygen-Glucose Deprivation/Reoxygenation-Induced Barrier Disruption at the Human Blood-Brain Barrier is Partially Mediated Through the HIF-1 Pathway. 38
30911877 2019
44
Detection of Brain Hypoxia Based on Noninvasive Optical Monitoring of Cerebral Blood Flow with Diffuse Correlation Spectroscopy. 38
30030667 2019
45
Migrainous Infarction in a Patient With Sporadic Hemiplegic Migraine and Cystic Fibrosis: A 99mTc-HMPAO Brain SPECT Study. 38
30620050 2019
46
Cerebral malaria. 38
30658131 2019
47
Tonic electromyographic activity following bilateral tonic-clonic seizures is associated with periictal respiratory dysfunction and postictal generalized EEG suppression. 38
30630218 2019
48
Further options and survival results after failure following extracorporeal life support implantation. 38
29616522 2019
49
No neurodevelopmental benefit of cerebral oximetry in the first randomised trial (SafeBoosC II) in preterm infants during the first days of life. 38
29908039 2019
50
Haemodynamic Instability and Brain Injury in Neonates Exposed to Hypoxia⁻Ischaemia. 38
30818842 2019

Variations for Cerebral Hypoxia

Expression for Cerebral Hypoxia

Search GEO for disease gene expression data for Cerebral Hypoxia.

Pathways for Cerebral Hypoxia

Pathways related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.09 PTK2 ITGB1 ITGAV IGF1 CREB1 CASP9
2
Show member pathways
13.94 PTK2 NOS1 ITGB1 ITGAV FOS CREB1
3
Show member pathways
13.8 PTK2 ITGB1 ITGAV IGF1 FOS CREB1
4
Show member pathways
13.76 PTK2 ITGB1 ITGAV IGF1 FOS CREB1
5
Show member pathways
13.65 PTK2 ITGB1 ITGAV IGF1 FOS CREB1
6
Show member pathways
13.35 PTK2 ITGB1 ITGAV FOS CREB1 CASP3
7
Show member pathways
13.33 PTK2 ITGB1 ITGAV IGF1 FOS CREB1
8
Show member pathways
13.27 PTK2 NOS1 ITGB1 ITGAV IGF1 BCAR1
9
Show member pathways
13.24 PTK2 IGF1 FOS CASP9 CASP3
10
Show member pathways
13 PTK2 ITGB1 ITGAV IGF1 CREB1 CAMK4
11
Show member pathways
12.99 PTK2 IGF1 FOS CASP3 CAMK4 BCAR1
12
Show member pathways
12.96 PTK2 ITGB1 ITGAV IGF1 FOS
13
Show member pathways
12.93 PTK2 ITGB1 ITGAV IGF1 CREB1 CASP9
14
Show member pathways
12.9 PTK2 NOS1 ITGB1 ITGAV FOS BCAR1
15
Show member pathways
12.9 PTK2 ITGAV FOS CREB1 CASP9 CASP3
16
Show member pathways
12.88 PTK2 ITGB1 IGF1 FOS BCAR1
17
Show member pathways
12.87 PTK2 ITGB1 ITGAV IGF1 FOS BCAR1
18
Show member pathways
12.83 FOS CREB1 CASP9 CASP3
19
Show member pathways
12.81 PTK2 ITGB1 ITGAV IGF1 CREB1 CASP9
20
Show member pathways
12.79 PTK2 ITGB1 ITGAV FOS CREB1 CAMK4
21
Show member pathways
12.79 PTK2 ITGB1 IGF1 FOS CASP9 CASP3
22
Show member pathways
12.77 IGF1 FOS CASP9 CASP3
23 12.76 PTK2 ITGB1 ITGAV IGF1 FOS CASP9
24 12.73 IGF1 FOS CASP9 CASP3
25
Show member pathways
12.66 PTK2 IGF1 FOS CASP9
26
Show member pathways
12.65 FOS CREB1 CASP9 CASP3
27
Show member pathways
12.61 NOS1 FOS CREB1 CASP9 CASP3 CAMK4
28
Show member pathways
12.6 PTK2 ITGB1 ITGAV BCAR1
29 12.6 PTK2 ITGB1 ITGAV BCAR1
30
Show member pathways
12.59 PTK2 NOS1 ITGB1 FOS CASP9
31
Show member pathways
12.55 PTK2 IGF1 CASP9 BCAR1
32
Show member pathways
12.52 NOS1 FOS CREB1 CAMK4
33
Show member pathways
12.51 ITGB1 ITGAV FOS CREB1 CASP9 CASP3
34
Show member pathways
12.5 PTK2 ITGB1 IGF1 FOS CASP9 CASP3
35
Show member pathways
12.5 PTK2 ITGB1 IGF1 FOS CREB1 CASP9
36
Show member pathways
12.48 PTK2 ITGB1 FOS CREB1 CASP3
37
Show member pathways
12.44 PTK2 ITGB1 ITGAV CASP9 CASP3
38
Show member pathways
12.43 PTK2 ITGB1 ITGAV
39
Show member pathways
12.4 PTK2 ITGAV FOS CREB1 CASP9
40
Show member pathways
12.39 IGF1 FOS CREB1 CASP9
41
Show member pathways
12.38 IGF1 CREB1 CASP9 CASP3
42
Show member pathways
12.38 ITGB1 ITGAV IGF1 FOS BCAR1
43 12.31 PTK2 ITGB1 ITGAV IGF1 CASP3
44
Show member pathways
12.29 FOS CREB1 CAMK4
45 12.29 FOS CREB1 CAMK4
46
Show member pathways
12.28 IGF1 CREB1 CAMK4
47
Show member pathways
12.26 ITGB1 FOS CASP9 CASP3
48
Show member pathways
12.22 FOS CREB1 CASP3
49
Show member pathways
12.22 ITGB1 ITGAV IGF1
50
Show member pathways
12.22 FOS CASP9 CASP3

GO Terms for Cerebral Hypoxia

Cellular components related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lamellipodium GO:0030027 9.43 PTK2 ITGB1 BCAR1
2 dendritic spine GO:0043197 9.33 PTK2 NOS1 ITGB1
3 integrin complex GO:0008305 9.32 ITGB1 ITGAV
4 focal adhesion GO:0005925 9.26 PTK2 ITGB1 ITGAV BCAR1
5 alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867 8.62 ITGAV IGF1

Biological processes related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.92 PTK2 ITGB1 ITGAV IGF1
2 positive regulation of transcription, DNA-templated GO:0045893 9.88 NOS1 IGF1 FOS CREB1 CAMK4
3 extracellular matrix organization GO:0030198 9.81 PTK2 ITGB1 ITGAV
4 cell migration GO:0016477 9.81 ITGB1 ITGAV BCAR1
5 positive regulation of apoptotic process GO:0043065 9.8 ITGB1 CREB1 CASP9 CASP3
6 aging GO:0007568 9.78 FOS CREB1 CASP9
7 response to hypoxia GO:0001666 9.77 NOS1 CREB1 CASP3
8 positive regulation of cell migration GO:0030335 9.71 PTK2 ITGAV IGF1 BCAR1
9 response to organic cyclic compound GO:0014070 9.7 FOS CASP9 CASP3
10 response to antibiotic GO:0046677 9.63 CASP9 CASP3
11 ERK1 and ERK2 cascade GO:0070371 9.62 ITGAV IGF1
12 response to lipopolysaccharide GO:0032496 9.62 NOS1 FOS CASP9 CASP3
13 heterotypic cell-cell adhesion GO:0034113 9.61 ITGB1 ITGAV
14 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.61 PTK2 ITGAV BCAR1
15 positive regulation of cardiac muscle hypertrophy GO:0010613 9.6 PTK2 IGF1
16 cell adhesion mediated by integrin GO:0033627 9.58 ITGB1 ITGAV
17 positive regulation of osteoclast differentiation GO:0045672 9.58 FOS CREB1
18 neurotrophin TRK receptor signaling pathway GO:0048011 9.57 CASP3 BCAR1
19 platelet formation GO:0030220 9.56 CASP9 CASP3
20 cell-substrate adhesion GO:0031589 9.55 ITGB1 ITGAV
21 negative regulation of anoikis GO:2000811 9.54 PTK2 ITGB1
22 cellular response to hepatocyte growth factor stimulus GO:0035729 9.51 CREB1 BCAR1
23 response to cobalt ion GO:0032025 9.46 CASP9 CASP3
24 glial cell apoptotic process GO:0034349 9.37 CASP9 CASP3
25 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.33 ITGAV CASP9 CASP3
26 leukocyte apoptotic process GO:0071887 9.26 CASP9 CASP3
27 transforming growth factor beta receptor signaling pathway GO:0007179 9.26 PTK2 ITGB1 FOS CREB1
28 integrin-mediated signaling pathway GO:0007229 8.92 PTK2 ITGB1 ITGAV BCAR1

Molecular functions related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.5 ITGB1 ITGAV IGF1
2 coreceptor activity GO:0015026 9.4 ITGB1 ITGAV
3 fibronectin binding GO:0001968 9.37 ITGB1 ITGAV
4 protease binding GO:0002020 9.33 ITGB1 ITGAV CASP3
5 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.26 CASP9 CASP3
6 cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097199 8.96 CASP9 CASP3
7 C-X3-C chemokine binding GO:0019960 8.62 ITGB1 ITGAV

Sources for Cerebral Hypoxia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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