Cerebral Hypoxia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CRB090 MIFTS: 43	Cerebral Hypoxia Categories: Neuronal diseases
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Aliases & Classifications for Cerebral Hypoxia

MalaCards integrated aliases for Cerebral Hypoxia:

Name: Cerebral Hypoxia ⁵³ ⁵⁴

Brain Hypoxia ⁷¹

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

UMLS ⁷¹ C1527348

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Summaries for Cerebral Hypoxia

NINDS : ⁵³ Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death. In brain death, there is no measurable activity in the brain, although cardiovascular function is preserved. Life support is required for respiration.

MalaCards based summary : Cerebral Hypoxia, also known as brain hypoxia, is related to brain injury and traumatic brain injury. An important gene associated with Cerebral Hypoxia is CAMK4 (Calcium/Calmodulin Dependent Protein Kinase IV), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Sevoflurane and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart, and related phenotypes are Increased viability with paclitaxel and cellular

Wikipedia : ⁷⁴ Cerebral hypoxia is a form of hypoxia (reduced supply of oxygen), specifically involving the brain; when... more...

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Related Diseases for Cerebral Hypoxia

Diseases related to Cerebral Hypoxia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)

#	Related Disease	Score	Top Affiliating Genes
1	brain injury	30.0	IGF1 CASP3
2	traumatic brain injury	29.8	IGF1 CASP3
3	ocular dominance	29.3	NOS1 CREB1
4	neuroblastoma	27.2	PTK2 ITGB1 IGF1 FOS CREB1 CASP9
5	hypoxia	11.9
6	anoxia	11.8
7	ischemia	10.6
8	carotid artery occlusion	10.3
9	cardiac arrest	10.2
10	encephalopathy	10.1
11	neonatal hypoxic and ischemic brain injury	10.1
12	retrograde amnesia	10.0	FOS CREB1
13	ocular motor apraxia	10.0
14	cerebral artery occlusion	10.0
15	respiratory failure	10.0
16	cerebrovascular disease	10.0
17	intracranial hypertension	10.0
18	myoclonus	10.0
19	cerebral palsy	9.9
20	opiate dependence	9.9	IGF1 FOS CREB1
21	amelogenesis imperfecta, type ig	9.9	IGF1 FOS CREB1
22	teeth hard tissue disease	9.9	IGF1 FOS CREB1
23	morphine dependence	9.9	FOS CREB1
24	stroke, ischemic	9.8
25	visual epilepsy	9.8
26	status epilepticus	9.8
27	dystonia	9.8
28	cerebral atrophy	9.8
29	seizure disorder	9.8
30	posttransplant acute limbic encephalitis	9.8
31	occlusion precerebral artery	9.8	FOS CASP3
32	cardiomyopathy, familial hypertrophic, 25	9.8	FOS CASP3
33	atherosclerosis susceptibility	9.7
34	migraine with or without aura 1	9.7
35	triiodothyronine receptor auxiliary protein	9.7
36	moyamoya disease 1	9.7
37	sudden infant death syndrome	9.7
38	body mass index quantitative trait locus 11	9.7
39	yemenite deaf-blind hypopigmentation syndrome	9.7
40	body mass index quantitative trait locus 9	9.7
41	body mass index quantitative trait locus 8	9.7
42	body mass index quantitative trait locus 4	9.7
43	body mass index quantitative trait locus 10	9.7
44	body mass index quantitative trait locus 7	9.7
45	diabetes mellitus, ketosis-prone	9.7
46	body mass index quantitative trait locus 12	9.7
47	body mass index quantitative trait locus 14	9.7
48	body mass index quantitative trait locus 18	9.7
49	chorea, childhood-onset, with psychomotor retardation	9.7
50	body mass index quantitative trait locus 19	9.7

Graphical network of the top 20 diseases related to Cerebral Hypoxia:

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Symptoms & Phenotypes for Cerebral Hypoxia

GenomeRNAi Phenotypes related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased viability with paclitaxel	GR00179-A-1	8.32	CASP3

MGI Mouse Phenotypes related to Cerebral Hypoxia:

⁴⁵ (show all 16)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.29	BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
2	growth/size/body region	MP:0005378	10.25	BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
3	endocrine/exocrine gland	MP:0005379	10.22	CAMK4 CASP3 CASP9 CREB1 FOS IGF1
4	cardiovascular system	MP:0005385	10.21	BCAR1 CASP3 CASP9 CREB1 IGF1 ITGAV
5	mortality/aging	MP:0010768	10.17	BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
6	hematopoietic system	MP:0005397	10.15	CAMK4 CASP3 CASP9 FOS IGF1 ITGAV
7	homeostasis/metabolism	MP:0005376	10.13	CAMK4 CASP3 CREB1 FOS IGF1 ITGAV
8	immune system	MP:0005387	10.11	CAMK4 CASP3 CASP9 FOS IGF1 ITGAV
9	embryo	MP:0005380	10.08	BCAR1 CASP9 CREB1 FOS ITGAV ITGB1
10	nervous system	MP:0003631	10.02	CAMK4 CASP3 CASP9 CREB1 FOS IGF1
11	muscle	MP:0005369	10.01	BCAR1 CASP3 CREB1 IGF1 ITGAV ITGB1
12	normal	MP:0002873	9.8	CAMK4 CREB1 FOS IGF1 ITGB1 NOS1
13	neoplasm	MP:0002006	9.77	FOS IGF1 ITGAV ITGB1 PTK2
14	reproductive system	MP:0005389	9.76	CAMK4 CASP3 CREB1 FOS IGF1 ITGB1
15	respiratory system	MP:0005388	9.5	CASP3 CASP9 CREB1 IGF1 ITGB1 NOS1
16	skeleton	MP:0005390	9.17	CAMK4 CASP3 CREB1 FOS IGF1 ITGB1

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Drugs & Therapeutics for Cerebral Hypoxia

Drugs for Cerebral Hypoxia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Sevoflurane

Approved, Vet_approved

Phase 4

28523-86-6

5206

Fentanyl

Approved, Illicit, Investigational, Vet_approved

Phase 4

437-38-7

3345

Epinephrine

Approved, Vet_approved

Phase 4

51-43-4

5816

Racepinephrine

Approved

Phase 4

329-65-7

838

Anesthetics, Intravenous

Phase 4

Ether

Phase 4

Epinephryl borate

Phase 4

Mannitol

Approved, Investigational

Phase 3

69-65-8

6251 453

Allopurinol

Approved

Phase 3

315-30-0

2094

Creatine

Approved, Investigational, Nutraceutical

Phase 3

57-00-1

586

Antioxidants

Phase 3

Protective Agents

Phase 3

Antirheumatic Agents

Phase 3

diuretics

Phase 3

Antimetabolites

Phase 3

Clonidine

Approved

Phase 1, Phase 2

4205-90-7

2803

Xenon

Experimental

Phase 2

7440-63-3

Anesthetics, General

Phase 2

Anesthetics, Inhalation

Phase 2

Neurotransmitter Agents

Phase 1, Phase 2

Antihypertensive Agents

Phase 1, Phase 2

Analgesics

Phase 1, Phase 2

Adrenergic alpha-Agonists

Phase 1, Phase 2

Adrenergic Agents

Phase 1, Phase 2

Sympatholytics

Phase 1, Phase 2

Adrenergic Agonists

Phase 1, Phase 2

Propofol

Approved, Investigational, Vet_approved

2078-54-8

4943

Remifentanil

Approved

132875-61-7

60815

Nitroglycerin

Approved, Investigational

55-63-0

4510

Glycerol

Approved, Investigational

56-81-5

753

Desflurane

Approved

57041-67-5

42113

Temozolomide

Approved, Investigational

85622-93-1

5394

Dexmedetomidine

Approved, Vet_approved

113775-47-6

5311068 68602

Dopamine

Approved

51-61-6, 62-31-7

681

Alprostadil

Approved, Investigational

745-65-3

149351 5280723

tannic acid

Approved

1401-55-4

Benzocaine

Approved, Investigational

94-09-7, 1994-09-7

2337

Glutamic acid

Approved, Nutraceutical

56-86-0

33032

Vitamin A

Approved, Nutraceutical, Vet_approved

22737-96-8, 68-26-8, 11103-57-4

9904001 445354

Cysteine

Approved, Nutraceutical

52-90-4

5862

Resveratrol

Investigational

501-36-0

445154

Platelet Aggregation Inhibitors

Pharmaceutical Solutions

Analgesics, Non-Narcotic

Anti-Inflammatory Agents

Anti-Inflammatory Agents, Non-Steroidal

Antipyretics

Dopamine Agents

Dopamine agonists

3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol

Interventional clinical trials:

(show top 50) (show all 66)

#	Name	Status	NCT ID	Phase	Drugs
1	Sevoflurane-based Volatile Induction and Maintenance of Anaesthesia (VIMA) Strategy Decreases the Risk of Postoperative Delirium in Elderly Patients With Registered Cerebral Hypoxemia Episodes During General Surgery	Unknown status	NCT02133638	Phase 4	Sevoflurane;Propofol
2	Does the Early Use of Sodium Bicarbonate Improve Results of Cardiopulmonary Resuscitation Following Out-of-Hospital Cardiac Arrest - a Prospective, Controlled Clinical Trial	Unknown status	NCT01377337	Phase 4	sodium bicarbonate
3	Hyperoxia: An Unrecognized Mechanism for Inducing "Hypoxia-Like" Symptoms	Completed	NCT03268590	Phase 4	Oxygen
4	Multicenter Double-blind Placebo-controlled Parallel-group Randomized Clinical Trial of Efficacy and Safety of Tenoten for Children Liquid Dosage Form Therapy in Infants With Sequelae of Perinatal Brain Injury	Completed	NCT03159611	Phase 3	Tenoten for children;Placebo
5	Randomized Controlled Trial of Hypothermia for Hypoxic-Ischemic Encephalopathy in Term Infants	Completed	NCT00005772	Phase 3
6	Evaluation of Systemic Hypothermia Initiated After 6 Hours of Age in Infants ≥36 Weeks Gestation With Hypoxic-Ischemic Encephalopathy: A Bayesian Evaluation. A Protocol for the NICHD Neonatal Research Network	Completed	NCT00614744	Phase 2, Phase 3
7	Creatine as a New Treatment for Schizophrenia:A Double-Blind Trial	Completed	NCT00140192	Phase 3	creatine
8	Effect of ALlopurinol in Addition to Hypothermia for Hypoxic-ischemic Brain Injury on Neurocognitive Outcome - a Blinded Randomized Placebo-controlled Parallel Group Multicenter Trial for Superiority (Phase III)	Recruiting	NCT03162653	Phase 3	Allopurinol;Mannitol
9	A Randomized Trial of Targeted Temperature Management With Whole Body Hypothermia For Moderate And Severe Hypoxic-Ischemic Encephalopathy In Premature Infants 33-35 Weeks Gestational Age.	Recruiting	NCT01793129	Phase 2, Phase 3
10	Optimizing Cooling Strategies at < 6 Hours of Age for Neonatal Hypoxic-Ischemic Encephalopathy	Terminated	NCT01192776	Phase 3
11	Neuroplasticity of Brain-Asphyxiated Infants: Efficacy of Intervention	Completed	NCT00006516	Phase 2
12	Anesthesia vs Aviation: Does Added Carbon Dioxide in Normobaric Hypoxia Have the Same Effect on Cerebral Oxygenation as in Hypobaric Hypoxia?	Completed	NCT03338907	Phase 2	Oxycarbon (5% CO2+ 95% O2)
13	Phase 2 Study of Effect of Xenon, in Combination With Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest Patients	Completed	NCT00879892	Phase 2	xenon
14	Phase I-II Clinical Trial to Determine the Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia	Completed	NCT01862250	Phase 1, Phase 2	Clonidine (Duraclon®)
15	Role of Cerebral Blood Flow on Ventilatory Stability During Sleep in Normoxia and Intermittent Hypoxia	Not yet recruiting	NCT03255408	Phase 1, Phase 2	Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep;Drug Lowering CBF and Intermittent Hypoxia Sleep;Placebo and Normoxia Sleep;Placebo and Intermittent Hypoxia Sleep
16	Neuroprotective Role of Lactate Therapy in Humans With Traumatic Brain Injury	Unknown status	NCT01573507
17	The Difference in Cerebral Oxygenation Between Propofol and Sevoflurane	Completed	NCT01757561
18	Perioperative Interventions to Optimize Cerebral Oxygen Saturation (rSO2) in High-risk Patients Undergoing Cardiac Surgery Should Have a Beneficial Systemic Effect for Enhancing Global Tissue Perfusion and Improve Outcomes.	Completed	NCT01432184
19	The Effects of Hypobaria vs Hypoxia on Cerebral Vasoreactivity, Brain's Electrical Activity and Concentration Performance on Pilots.	Completed	NCT03303118
20	Assessment of Tele-expertise for the Interpretation of MRI Among Neonates With High Risk of Neurological Sequelae	Completed	NCT03706651
21	Pilot Trial Concerning Glutamate Elimination With CRRT for Neurological Outcome After Cardiac Arrest	Completed	NCT02963298
22	Septic Shock and Delirium Because of rSO2 Abnormalities in Intensive Care Unit Patients (The SAD BRAIN Study)	Completed	NCT01836302
23	Near Infrared Spectroscopy in Aortic Valve Replacement	Completed	NCT01251328
24	The Impact of a Beach Chair Position During Shoulder Arthroscopy on Regional Cerebral Oxygen Saturation : Comparison of Interscalene Block and General Anesthesia	Completed	NCT02605005
25	Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia	Completed	NCT02482571
26	Oxygenation of the Neonatal Brain - a Study Using the INVOS Oximeter	Completed	NCT01690650		Oxygen
27	Oxygenation of the Neonatal Brain - a Study Using the INVOS Oximeter	Completed	NCT01684618
28	Assessment of Hypoxic Brain Injury by Analyzing Propofol-induced EEG Changes	Completed	NCT03485781
29	Effects of High Inspiratory Oxygen on Cerebral Tissue Oxygenation and Patient Recovery After Carotid Endarterectomy	Completed	NCT02991976
30	Postoperative Delirium in Patients Undergoing Hip Arthroplasty	Completed	NCT02323984
31	Effect of Hypotensive Anesthesia on Cerebral Perfusion and Blood Antioxidant Levels and HIF 1a	Completed	NCT04174417
32	A Multicentre Prospective Study on Magnetic Resonance Biomarkers in Neonatal Encephalopathy	Completed	NCT01309711
33	The Effects of Acute Trans-resveratrol Supplementation on Aspects of Cognitive Function and Cerebral Blood Flow, During Hypoxia and Normoxia, in Healthy, Young Humans.	Completed	NCT03100019		Placebo
34	Comparison of Low Versus Normal Flow Anesthesia on Cerebral Oxygenation and Bispectral Index in Morbidly Obese Patients Undergoing Sleeve Gastrectomy: Prospective, Randomized Clinical Trial	Completed	NCT03438734
35	Retrospective Evaluation of Prognostic and/or Predictive Profile of Melanocortin Receptor-4 Gene Polymorphisms in Patient With a Diagnosis of Glioblastoma Treated With Upfront Concomitant Radio-chemotherapy or Chemotherapy	Completed	NCT02458508
36	Evaluation of the Cerebral Responses to Exercise in Hypoxia	Completed	NCT01614119
37	Predicting Neurological Outcome Following Out of Hospital Cardiac Arrest (OHCA) by Quantitative Measurement of Serial Serum Biomarkers of Brain Injury.	Completed	NCT03112486
38	Brain-computer Interface in the Diagnosis of Disorders of Consciousness	Completed	NCT03998930
39	Hypoxia and Outcome Prediction in Early Stage Coma: Towards an Improvement of Clinical and Electrophysiological Predictors	Completed	NCT02231060
40	EARLY TRACHEOSTOMY VERSUS STANDARD OF CARE, A RANDOMIZED CONTROLLED CLINICAL TRIAL IN PATIENTS WITH SEVERE HEAD INJURY IN MULAGO HOSPITAL	Completed	NCT02442154
41	Optimizing Cerebral Oxygenation in Cardiac Surgery	Completed	NCT01539382
42	BiHiVE 2 Study. The Investigation and Validation of Predictive Biomarkers in Hypoxic-ischaemic Encephalopathy.	Completed	NCT02019147
43	Cardio-respiratory Events in VLBW Preterm Infants During the Transitional Period: Clinical Features and Impact of Neonatal Characteristics.	Completed	NCT04123691
44	Validation of the Predictive Value of the FORE-SIGHT™ Monitor for Early Detection of Hemodynamic Deterioration After Pediatric Cardiac Surgery. A Data-mining Study.	Completed	NCT01706497
45	Impact of Early Optimization of Brain Oxygenation on Neurological Outcome After Severe Traumatic Brain Injury	Recruiting	NCT02754063
46	Correlating Brain Tissue Oxygen Tension (PbrO2) and Regional Cerebral Oximetry (rSO2) in Normal Human Brain Under the Conditions of Changing Ventilation Strategy	Recruiting	NCT03128957
47	Cerebral Regional Tissue Oxygen Saturation to Guide Oxygen Delivery in Preterm Neonates During Immediate Transition After Birth: An Investigator-initiated Randomised Multi-centre Multinational Clinical Trial	Recruiting	NCT03166722
48	TAME Cardiac Arrest Trial: Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest: A Phase III Multi-Centre Randomised Controlled Trial	Recruiting	NCT03114033
49	Transfusion Strategies in Acute Brain Injured Patients. A Prospective Multicenter Randomized Study.	Recruiting	NCT02968654
50	Safety, Tolerability, and Early Efficacy of Immersive Virtual Reality for Early Neurocognitive Stimulation in the Intensive Care Unit.	Recruiting	NCT03569358

Search NIH Clinical Center for Cerebral Hypoxia

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Genetic Tests for Cerebral Hypoxia

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Anatomical Context for Cerebral Hypoxia

MalaCards organs/tissues related to Cerebral Hypoxia:

⁴⁰

Brain, Cortex, Heart, Endothelial, Liver, Testes, Kidney

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Publications for Cerebral Hypoxia

Articles related to Cerebral Hypoxia:

(show top 50) (show all 1697)

#	Title	Authors	PMID	Year
1	Effect of hypoxia on the expression of procaspase-9 and procaspase-3 in neuronal nuclear, mitochondrial and cytosolic fractions of the cerebral cortex of newborn piglets. ⁶¹ ⁵⁴	Delivoria-Papadopoulos M...Mishra OP	18468794	2008
2	ATP and cytochrome c-dependent activation of caspase-9 during hypoxia in the cerebral cortex of newborn piglets. ⁵⁴ ⁶¹	Delivoria-Papadopoulos M...Mishra OP	17976908	2007
3	Differential expression of apoptotic proteins following hypoxia-induced CREB phosphorylation in the cerebral cortex of newborn piglets. ⁶¹ ⁵⁴	Delivoria-Papadopoulos M...Mishra OP	17401658	2007
4	Mechanism of activation of caspase-9 and caspase-3 during hypoxia in the cerebral cortex of newborn piglets: the role of nuclear Ca2+ -influx. ⁵⁴ ⁶¹	Delivoria-Papadopoulos M...Mishra OP	17268855	2007
5	Hypoxia-induced Bax and Bcl-2 protein expression, caspase-9 activation, DNA fragmentation, and lipid peroxidation in mitochondria of the cerebral cortex of newborn piglets: the role of nitric oxide. ⁵⁴ ⁶¹	Mishra OP...Delivoria-Papadopoulos M	16777344	2006
6	Effect of 7-nitroindazole sodium on the cellular distribution of neuronal nitric oxide synthase in the cerebral cortex of hypoxic newborn piglets. ⁶¹ ⁵⁴	Katsetos CD...Mishra OP	16804757	2006
7	Effect of neuronal nitric oxide synthase inhibition on caspase-9 activity during hypoxia in the cerebral cortex of newborn piglets. ⁵⁴ ⁶¹	Mishra OP...Delivoria-Papadopoulos M	16545906	2006
8	Anaemia and the brain. ⁶¹ ⁵⁴	Hare GM	17023891	2004
9	Effect of hypoxia on protein phosphatase 2A activity, subcellular distribution and expression in cerebral cortex of newborn piglets. ⁵⁴ ⁶¹	Truttmann AC...Delivoria-Papadopoulos M	15262326	2004
10	Offspring of rats with cerebral hypoxia-ischemia manifest cognitive dysfunction in learning and memory abilities. ⁶¹	Xue LL...Xiong LL	32209770	2020
11	Endogenous brain-sparing responses in brain pH and PO2 in a rodent model of birth asphyxia. ⁶¹	Pospelov AS...Voipio J	32174009	2020
12	Nitric oxide and the brain. Part 2: Effects following neonatal brain injury-friend or foe? ⁶¹	Angelis D...Chalak L	32563184	2020
13	Microglial-specific depletion of TAK1 is neuroprotective in the acute phase after ischemic stroke. ⁶¹	Zeyen T...Habib P	32382778	2020
14	Hypoxia-induced apoptosis of astrocytes is mediated by reduction of Dicer and activation of caspase-1. ⁶¹	Kang YW...Cho WG	32129540	2020
15	Genetically Encoded Tools for Research of Cell Signaling and Metabolism under Brain Hypoxia. ⁶¹	Kostyuk AI...Bilan DS	32545356	2020
16	Flavin Adenine Dinucleotide Fluorescence as an Early Marker of Mitochondrial Impairment During Brain Hypoxia. ⁶¹	Berndt N...Liotta A	32492921	2020
17	Nitric oxide and the brain. Part 1: Mechanisms of regulation, transport and effects on the developing brain. ⁶¹	Angelis D...Chalak L	32563183	2020
18	Hanging disguised as bondage: accidental or suicidal death? ⁶¹	Alongi A...Ventura Spagnolo E	32495262	2020
19	Protective effect of hydralazine on a cellular model of Parkinson's disease: a possible role of hypoxia-inducible factor (HIF)-1α. ⁶¹	Mehrabani M...Mirzamohammadi S	31940231	2020
20	Changes in arginase isoforms in a murine model of neonatal brain hypoxia-ischemia. ⁶¹	Mike JK...Ferriero DM	32464635	2020
21	Metoprolol prevents neuronal dendrite remodeling in a canine model of chronic obstructive sleep apnea. ⁶¹	Yang L...Ai J	31863057	2020
22	Is jugular bulb oximetry monitoring associated with outcome in out of hospital cardiac arrest patients? ⁶¹	Richter J...Chatterjee N	32435933	2020
23	Landmark clinical observations and immunopathogenesis pathways linked to HIV and Cryptococcus fatal central nervous system co-infection. ⁶¹	Okurut S...Meya DB	32472727	2020
24	A management algorithm for adult patients with both brain oxygen and intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC). ⁶¹	Chesnut R...Hawryluk GWJ	31965267	2020
25	Pharmacological HIF1 Inhibition Eliminates Downregulation of the Pentose Phosphate Pathway and Prevents Neuronal Apoptosis in Rat Hippocampus Caused by Severe Hypoxia. ⁶¹	Vetrovoy O...Rybnikova E	31865524	2020
26	Determining the impacts of venoarterial extracorporeal membrane oxygenation on cerebral oxygenation using a one-dimensional blood flow simulator. ⁶¹	Feiger B...Randles A	32220425	2020
27	Burden of hypoxia and intraventricular haemorrhage in extremely preterm infants. ⁶¹	Ng IHX...Austin T	31256012	2020
28	Neuroimaging provides relevant clinical information in patients with burn injuries. ⁶¹	Concannon E...Shelley O	31787472	2020
29	Defining a Time Window for Neuroprotection and Glia Modulation by Caffeine After Neonatal Hypoxia-Ischaemia. ⁶¹	Di Martino E...Aden U	31974940	2020
30	Clinical Usefulness of Transcranial Doppler as a Screening Tool for Early Cerebral Hypoxic Episodes in Patients with Moderate and Severe Traumatic Brain Injury. ⁶¹	Sokoloff C...ERESI Reseach Group (Equipe de Recherche En Soins Intensifs)	31218643	2020
31	Comprehensive Functional Echocardiographic Assessment of Transposition of the Great Arteries: From Fetus to Newborn. ⁶¹	Walter C...Sanchez-de-Toledo J	31919591	2020
32	Near-Infrared Spectroscopy Reveals Brain Hypoxia and Cerebrovascular Dysregulation in Primary Biliary Cholangitis. ⁶¹	Duszynski CC...Swain MG	31535726	2020
33	Maternal Undernourishment in Guinea Pigs Leads to Fetal Growth Restriction with Increased Hypoxic Cells and Oxidative Stress in the Brain. ⁶¹	Maki Y...Richardson BS	32316015	2020
34	NIRS in the fetal to neonatal transition and immediate postnatal period. ⁶¹	Bruckner M...Urlesberger B	32007425	2020
35	Brain Hypoxia Secondary to Diffusion Limitation in Hypoxic Ischemic Brain Injury Postcardiac Arrest. ⁶¹	Sekhon MS...Griesdale DE	31789834	2020
36	In a Rat Model of Opioid Maintenance, the G Protein-Biased Mu Opioid Receptor Agonist TRV130 Decreases Relapse to Oxycodone Seeking and Taking and Prevents Oxycodone-Induced Brain Hypoxia. ⁶¹	Bossert JM...Shaham Y	32305216	2020
37	Wheel running for 26 weeks is associated with sustained vascular plasticity in the rat motor cortex. ⁶¹	Stevenson ME...Swain RA	31870777	2020
38	A mathematical model of cerebral blood flow control in anaemia and hypoxia. ⁶¹	Duffin J...Fisher JA	31823369	2020
39	Cerebral blood flow dynamic in foetuses with hypoplastic left heart syndrome: Incremental value of the first segment of the anterior cerebral artery over the middle cerebral artery? ⁶¹	Liu Y...Zhao B	31525274	2020
40	Neuroprotective effects of resveratrol against oxygen glucose deprivation induced mitochondrial dysfunction by activation of AMPK in SH-SY5Y cells with 3D gelatin scaffold. ⁶¹	Lin CH...Chiang MC	31586626	2020
41	[APOΕ gene polymorphism and markers of brain damage in the outcomes of severe traumatic brain injury in children]. ⁶¹	Sorokina EG...Pinelis VG	32490622	2020
42	Neonatal cerebral hypoxia-ischemia in mice triggers age-dependent vascular effects and disabilities in adults; implication of tissue plasminogen activator (tPA). ⁶¹	Dupre N...Leroux P	31697944	2020
43	A New Rat Model of Chronic Cerebral Hypoperfusion Resulting in Early-Stage Vascular Cognitive Impairment. ⁶¹	Wang J...Yang Z	32351379	2020
44	Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy. ⁶¹	Obradovic M...Isenovic ER	31622925	2020
45	δ-Opioid Receptors, microRNAs, and Neuroinflammation in Cerebral Ischemia/Hypoxia. ⁶¹	Chen YM...Xia Y	32269564	2020
46	Multimodal monitoring to aid detection and management of intraoperative seizures: a case report. ⁶¹	Ajayan N...Prathapadas U	31960222	2020
47	Superimposed Guillain-Barré Syndrome (GBS) in pediatric hypoxic brain injury. ⁶¹	Leung E...Erlandson E	32176662	2020
48	Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemia. ⁶¹	Fernandez AF...Levine B	31941841	2020
49	The Role of Peripheral Opioid Receptors in Triggering Heroin-induced Brain Hypoxia. ⁶¹	Perekopskiy D...Kiyatkin EA	31964994	2020
50	Aqueous extract of Dendrobium officinale confers neuroprotection against hypoxic-ischemic brain damage in neonatal rats. ⁶¹	Li XL...Hong M	31642199	2020

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Genes for Cerebral Hypoxia

Genes related to Cerebral Hypoxia (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CAMK4	Calcium/Calmodulin Dependent Protein Kinase IV	Protein Coding	7.16	Novoseek inferred ⁵⁴	15262326
2	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	5.86	GeneCards inferred via : Publications (show sections)
3	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	5.86	GeneCards inferred via : Publications (show sections)
4	IGF1	Insulin Like Growth Factor 1	Protein Coding	5.86	GeneCards inferred via : Publications (show sections)
5	ITGAV	Integrin Subunit Alpha V	Protein Coding	5.86	GeneCards inferred via : Publications (show sections)
6	ITGB1	Integrin Subunit Beta 1	Protein Coding	5.86	GeneCards inferred via : Publications (show sections)
7	PTK2	Protein Tyrosine Kinase 2	Protein Coding	5.86	GeneCards inferred via : Publications (show sections)
8	CASP9	Caspase 9	Protein Coding	5.38	Novoseek inferred ⁵⁴	17268855 16777344 17976908 (more) 18468794 16545906
9	NOS1	Nitric Oxide Synthase 1	Protein Coding	4.39	Novoseek inferred ⁵⁴	17023891 16804757
10	CASP3	Caspase 3	Protein Coding	3.95	Novoseek inferred ⁵⁴	17268855 17976908
11	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	2.04	Novoseek inferred ⁵⁴	17401658

Sources

Variations for Cerebral Hypoxia

Sources

Expression for Cerebral Hypoxia

Search GEO for disease gene expression data for Cerebral Hypoxia.

Sources

Pathways for Cerebral Hypoxia

Pathways related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

(show top 50) (show all 103)

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by GPCR ⁶⁵ Show member pathways GPCR downstream signaling ⁶⁵ Signal Transduction ⁶⁵	14.08	PTK2 ITGB1 ITGAV IGF1 CREB1 CASP9
2	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.94	PTK2 NOS1 ITGB1 ITGAV FOS CREB1
3	Apoptotic Pathways in Synovial Fibroblasts ⁶³ Show member pathways Actin-Based Motility by Rho Family GTPases ⁶³ Cellular Apoptosis Pathway ⁶³ DHA Signaling ⁶³ eIF2 Pathway ⁶³ ERK5 Signaling ⁶³ Glioma Invasiveness ⁶³ Mitochondrial Apoptosis ⁶³ Nuclear Receptor Activation by Vitamin-A ⁶³ p53 Mediated Apoptosis ⁶³ PPAR Pathway ⁶³ Rac1 Pathway ⁶³ Rap1 Pathway ⁶³ Telomerase Components in Cell Signaling ⁶³	13.77	PTK2 ITGB1 ITGAV IGF1 FOS CREB1
4	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.73	PTK2 ITGB1 ITGAV IGF1 FOS CREB1
5	GPCR Pathway ⁶³ Show member pathways Breast Cancer Regulation by Stathmin1 ⁶³ Estrogen Pathway ⁶³ NFAT in Immune Response ⁶³ P2Y Receptor Signaling ⁶³ Pancreatic Adenocarcinoma ⁶³ Paxillin Interactions ⁶³ Ras Pathway ⁶³	13.63	PTK2 ITGB1 ITGAV IGF1 FOS CREB1
6	Integrin Pathway ⁶³ Show member pathways FAK1 Signaling ⁶³ GnRH Signaling ⁶³ Inhibition of Angiogenesis by TSP1 ⁶³ Transendothelial Migration of Leukocytes ⁶³ UPA-UPAR Pathway ⁶³	13.36	PTK2 ITGB1 ITGAV FOS CREB1 CASP3
7	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.33	PTK2 ITGB1 ITGAV IGF1 FOS CREB1
8	Response to elevated platelet cytosolic Ca2+ ⁶⁵ Show member pathways Disinhibition of SNARE formation ⁶⁵ Hemostasis ⁶⁵ Platelet activation, signaling and aggregation ⁶⁵ Platelet degranulation ⁶⁵	13.27	PTK2 NOS1 ITGB1 ITGAV IGF1 BCAR1
9	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.24	PTK2 IGF1 FOS CASP9 CASP3
10	Phospholipase-C Pathway ⁶³ Show member pathways PTEN Pathway ⁶³	13.01	PTK2 ITGB1 ITGAV IGF1 CREB1 CAMK4
11	fMLP Pathway ⁶³ Show member pathways Alpha-Adrenergic Signaling ⁶³ CCR3 Pathway in Eosinophils ⁶³ CXCR4 Pathway ⁶³ Huntington's Disease Pathway ⁶³ Internalin Pathway ⁶³ Signal transduction Activation of PKC via G-Protein coupled receptor ²² VEGF and S-1P Signaling ⁶³	12.96	PTK2 IGF1 FOS CASP3 CAMK4 BCAR1
12	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	12.92	PTK2 ITGB1 ITGAV IGF1 CREB1 CASP9
13	TNFR1 Pathway ⁶³ Show member pathways Apoptosis and survival TNFR1 signaling pathway ²² Apoptosis through Death Receptors ⁶³ Apoptotic Pathways Triggered By HIV1 ⁶³ Death Receptor Signaling ⁶⁶ DR3 Signaling ⁶³ Fas Signaling ⁶³ GITR Pathway ⁶³ HIV-1 Nef- Negative effector of Fas and TNF-alpha ¹ Stimulation of the cell death response by PAK-2p34 ⁶⁵ TNF alpha Signaling Pathway ¹ TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway ¹ TNF Signaling ⁶³ TNF Signaling ⁶⁶ TRAIL Pathway ⁶³ TWEAK Pathway ⁶³	12.91	PTK2 ITGB1 IGF1 FOS CASP9 CASP3
14	Sertoli-Sertoli Cell Junction Dynamics ⁶³ Show member pathways Epithelial Tight Junctions ⁶³ Germ Cell-Sertoli Cell Junction Dynamics ⁶³	12.9	PTK2 NOS1 ITGB1 ITGAV FOS BCAR1
15	Regulation of lipid metabolism Insulin signaling-generic cascades ²² Show member pathways acetyl-CoA biosynthesis from citrate ¹ Butyrate-induced histone acetylation ¹ Cell adhesion PLAU signaling ²² Class IB PI3K non-lipid kinase events ¹ Development CNTF receptor signaling ²² Development Growth hormone signaling via PI3K/AKT and MAPK cascades ²² ErbB2/ErbB3 signaling events ¹ Glucose Homeostasis ¹ Insulin signaling pathway ³⁶ IRS activation ⁶⁵ Signal attenuation ⁶⁵ Transcription Receptor-mediated HIF regulation ²² Translation Regulation of EIF2 activity ²² Translation Regulation of EIF4F activity ²² Translation Insulin regulation of translation ²²	12.88	PTK2 ITGB1 IGF1 FOS BCAR1
16	Focal Adhesion ³⁶ ¹ Show member pathways HGF Pathway ⁶³ Integrin-mediated Cell Adhesion ¹	12.87	PTK2 ITGB1 ITGAV IGF1 FOS BCAR1
17	Human cytomegalovirus infection ³⁶ Show member pathways Human immunodeficiency virus 1 infection ³⁶ Kaposi sarcoma-associated herpesvirus infection ³⁶	12.85	PTK2 ITGAV FOS CREB1 CASP9 CASP3
18	Development Angiotensin activation of ERK ²² Show member pathways Cell adhesion Integrin inside-out signaling ²² Development ACM2 and ACM4 activation of ERK ²² Development Angiotensin signaling via PYK2 ²² Development EDNRB signaling ²² Development EPO-induced MAPK pathway ²² Development G-Proteins mediated regulation MARK-ERK signaling ²² Signal transduction IP3 signaling ²²	12.79	PTK2 ITGB1 ITGAV FOS CREB1 CAMK4
19	NFAT and Cardiac Hypertrophy ⁶³ Show member pathways IGF1R Signaling ⁶³ Signaling Involved in Cardiac Hypertrophy ⁶³	12.78	PTK2 ITGB1 ITGAV IGF1 CREB1 CASP9
20	MAPK Erk Pathway ⁶⁶ Show member pathways Actin Dynamics Signaling Pathway ⁶⁶ G Protein coupled Receptors Signaling ⁶⁶	12.78	PTK2 NOS1 ITGB1 ITGAV FOS CREB1
21	Circadian entrainment ³⁶ Show member pathways Cholinergic synapse ³⁶ Dopaminergic synapse ³⁶ Glutamatergic synapse ³⁶ Synaptic Neurotransmission: Glutamatergic Excitation ⁶⁴	12.73	NOS1 FOS CREB1 CAMK4
22	Pathways in cancer ³⁶	12.73	PTK2 ITGB1 ITGAV IGF1 FOS CASP9
23	MAPK signaling pathway ³⁶ ¹	12.72	IGF1 FOS CASP9 CASP3
24	Apoptosis Modulation and Signaling ¹ Show member pathways Apoptosis ³⁶ Apoptosis ¹ Apoptosis and survival Apoptotic TNF-family pathways ²² Apoptosis Signaling Pathways ⁶⁴	12.67	IGF1 FOS CASP9 CASP3
25	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.66	PTK2 IGF1 FOS CASP9 CAMK4
26	Relaxin signaling pathway ³⁶ Show member pathways Estrogen signaling pathway ³⁶ Growth hormone synthesis, secretion and action ³⁶ Relaxin receptors ⁶⁵	12.63	PTK2 NOS1 IGF1 FOS CREB1 BCAR1
27	Regulation of actin cytoskeleton ³⁶ ¹	12.6	PTK2 ITGB1 ITGAV BCAR1
28	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶³ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.58	PTK2 NOS1 ITGB1 FOS CASP9
29	TRAF Pathway ⁶³ Show member pathways 14-3-3 Induced Apoptosis ⁶³ TNF Superfamily Pathway ⁶³ Toll-Like Receptors Pathway ⁶³	12.56	FOS CASP9 CASP3 BCAR1
30	Development Dopamine D2 receptor transactivation of EGFR ²² Show member pathways Apoptosis and survival BAD phosphorylation ²² BAD Phosphorylation ⁶³ Chemotaxis CXCR4 signaling pathway ²² Development Alpha-2 adrenergic receptor activation of ERK ²²	12.55	PTK2 IGF1 CASP9 BCAR1
31	Myometrial Relaxation and Contraction Pathways ¹ Show member pathways Calcium Regulation in the Cardiac Cell ¹	12.52	NOS1 FOS CREB1 CAMK4
32	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²² Thyroid cancer ³⁶	12.5	PTK2 ITGB1 IGF1 FOS CREB1 CASP9
33	Prolactin Signaling Pathway ³⁶ ¹ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	12.48	PTK2 ITGB1 FOS CREB1 CASP3
34	Apoptosis Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ NF-kappaB Pathway ⁷⁰	12.44	PTK2 ITGB1 ITGAV CASP9 CASP3
35	Development VEGF signaling via VEGFR2 - generic cascades ²² Show member pathways Development VEGF signaling and activation ²² VEGF - VEGF R2 Signaling Pathways ⁶⁴	12.4	PTK2 ITGAV FOS CREB1 CASP9
36	Development IGF-1 receptor signaling ²² Show member pathways IL-4 Signaling Pathway ¹ Immune response IL-4 signaling pathway ²² Signal transduction AKT signaling ²²	12.39	IGF1 FOS CREB1 CASP9
37	DNA Damage Response ¹ Show member pathways miRNA Regulation of DNA Damage Response ¹ p53 signaling pathway ³⁶	12.38	IGF1 CREB1 CASP9 CASP3
38	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ¹	12.38	ITGB1 ITGAV IGF1 FOS BCAR1
39	Proteoglycans in cancer ³⁶	12.31	PTK2 ITGB1 ITGAV IGF1 CASP3
40	G-protein signaling Ras family GTPases in kinase cascades (scheme) ²² Show member pathways Activation of the AP-1 family of transcription factors ⁶⁵ Immune response Oncostatin M signaling via MAPK in human cells ²² MAPK Cascade ¹ Nanoparticle-mediated activation of receptor signaling ¹ Oncostatin M Signaling Pathway ¹	12.29	PTK2 ITGB1 FOS CREB1 CASP3
41	Development Ligand-independent activation of ESR1 and ESR2 ²² Show member pathways Transcription CREB pathway ²² Transcription PPAR Pathway ²²	12.28	IGF1 CREB1 CAMK4
42	Pathogenic Escherichia coli infection ³⁶	12.27	ITGB1 FOS CASP9 CASP3
43	VEGF Signaling ⁶⁶ Show member pathways EGFR Signaling Pathway ⁶⁶ TGF-beta Signaling Pathway ⁶⁶ VEGF Signaling Pathway ⁶⁰	12.27	PTK2 NOS1 ITGAV FOS CASP9 CASP3
44	Toxoplasmosis ³⁶ Show member pathways Leishmaniasis ³⁶	12.26	ITGB1 FOS CASP9 CASP3
45	VEGF Pathway (Qiagen) ⁶³ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶³ Development VEGF-family signaling ²² Neurophilin interactions with VEGF and VEGFR ⁶⁵ VEGF Pathway ⁶³	12.24	PTK2 ITGB1 ITGAV FOS CREB1 CASP9
46	p53 Signaling ⁶³ Show member pathways P53 Pathway ⁶⁶	12.22	FOS CASP9 CASP3
47	Dilated cardiomyopathy (DCM) ³⁶ Show member pathways Hypertrophic cardiomyopathy (HCM) ³⁶	12.22	ITGB1 ITGAV IGF1
48	Tuberculosis ³⁶	12.2	CREB1 CASP9 CASP3
49	EGF/EGFR Signaling Pathway ¹	12.19	PTK2 FOS CREB1 BCAR1
50	MAPK Signaling: Mitogens ⁶⁴ Show member pathways Akt Signaling Pathway ⁶⁴	12.19	PTK2 ITGB1 ITGAV CREB1 CASP9 CASP3

Sources

GO Terms for Cerebral Hypoxia

Cellular components related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lamellipodium	GO:0030027	9.5	PTK2 ITGB1 BCAR1
2	focal adhesion	GO:0005925	9.46	PTK2 ITGB1 ITGAV BCAR1
3	dendritic spine	GO:0043197	9.43	PTK2 NOS1 ITGB1
4	integrin complex	GO:0008305	9.37	ITGB1 ITGAV
5	cell junction	GO:0030054	9.35	PTK2 NOS1 ITGB1 ITGAV BCAR1
6	alphav-beta3 integrin-IGF-1-IGF1R complex	GO:0035867	8.62	ITGAV IGF1

Biological processes related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

(show all 28)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:0008284	9.92	PTK2 ITGB1 ITGAV IGF1
2	positive regulation of transcription, DNA-templated	GO:0045893	9.88	NOS1 IGF1 FOS CREB1 CAMK4
3	positive regulation of apoptotic process	GO:0043065	9.8	ITGB1 CREB1 CASP9 CASP3
4	aging	GO:0007568	9.79	FOS CREB1 CASP9
5	response to hypoxia	GO:0001666	9.78	NOS1 CREB1 CASP3
6	response to organic cyclic compound	GO:0014070	9.7	FOS CASP9 CASP3
7	ERK1 and ERK2 cascade	GO:0070371	9.64	ITGAV IGF1
8	response to antibiotic	GO:0046677	9.63	CASP9 CASP3
9	heterotypic cell-cell adhesion	GO:0034113	9.63	ITGB1 ITGAV
10	response to lipopolysaccharide	GO:0032496	9.62	NOS1 FOS CASP9 CASP3
11	positive regulation of cardiac muscle hypertrophy	GO:0010613	9.61	PTK2 IGF1
12	vascular endothelial growth factor receptor signaling pathway	GO:0048010	9.61	PTK2 ITGAV BCAR1
13	positive regulation of wound healing	GO:0090303	9.6	PTK2 ITGB1
14	positive regulation of osteoclast differentiation	GO:0045672	9.59	FOS CREB1
15	cell adhesion mediated by integrin	GO:0033627	9.58	ITGB1 ITGAV
16	neurotrophin TRK receptor signaling pathway	GO:0048011	9.58	CASP3 BCAR1
17	cell-substrate adhesion	GO:0031589	9.57	ITGB1 ITGAV
18	platelet formation	GO:0030220	9.56	CASP9 CASP3
19	negative regulation of anoikis	GO:2000811	9.55	PTK2 ITGB1
20	cellular response to hepatocyte growth factor stimulus	GO:0035729	9.54	CREB1 BCAR1
21	positive regulation of fibroblast migration	GO:0010763	9.51	PTK2 ITGB1
22	response to cobalt ion	GO:0032025	9.46	CASP9 CASP3
23	transforming growth factor beta receptor signaling pathway	GO:0007179	9.46	PTK2 ITGB1 FOS CREB1
24	extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	9.43	ITGAV CASP9 CASP3
25	leukocyte apoptotic process	GO:0071887	9.4	CASP9 CASP3
26	glial cell apoptotic process	GO:0034349	9.37	CASP9 CASP3
27	integrin-mediated signaling pathway	GO:0007229	9.26	PTK2 ITGB1 ITGAV BCAR1
28	positive regulation of cell migration	GO:0030335	9.02	PTK2 ITGB1 ITGAV IGF1 BCAR1

Molecular functions related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protease binding	GO:0002020	9.43	ITGB1 ITGAV CASP3
2	fibronectin binding	GO:0001968	9.4	ITGB1 ITGAV
3	cysteine-type endopeptidase activity involved in apoptotic process	GO:0097153	9.37	CASP9 CASP3
4	cysteine-type endopeptidase activity involved in execution phase of apoptosis	GO:0097200	9.32	CASP9 CASP3
5	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	GO:0097199	9.16	CASP9 CASP3
6	C-X3-C chemokine binding	GO:0019960	8.96	ITGB1 ITGAV
7	integrin binding	GO:0005178	8.92	PTK2 ITGB1 ITGAV IGF1

Sources

Sources for Cerebral Hypoxia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia