Cerebral Hypoxia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CRB090 MIFTS: 45	Cerebral Hypoxia Categories: Neuronal diseases
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Aliases & Classifications for Cerebral Hypoxia

MalaCards integrated aliases for Cerebral Hypoxia:

Name: Cerebral Hypoxia ⁵⁴ ⁵⁵

Brain Hypoxia ⁷²

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

UMLS ⁷² C1527348

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Summaries for Cerebral Hypoxia

NINDS : ⁵⁴ Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death. In brain death, there is no measurable activity in the brain, although cardiovascular function is preserved. Life support is required for respiration.

MalaCards based summary : Cerebral Hypoxia, also known as brain hypoxia, is related to traumatic brain injury and ocular dominance. An important gene associated with Cerebral Hypoxia is CAMK4 (Calcium/Calmodulin Dependent Protein Kinase IV), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Propofol and Sevoflurane have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

Wikipedia : ⁷⁵ Cerebral hypoxia is a form of hypoxia (reduced supply of oxygen), specifically involving the brain; when... more...

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Related Diseases for Cerebral Hypoxia

Diseases related to Cerebral Hypoxia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)

#	Related Disease	Score	Top Affiliating Genes
1	traumatic brain injury	29.6	IGF1 CASP3
2	ocular dominance	28.9	NOS1 CREB1
3	hypoxia	11.9
4	anoxia	11.8
5	ischemia	10.5
6	carotid artery occlusion	10.3
7	cardiac arrest	10.2
8	brain injury	10.2
9	neonatal hypoxic and ischemic brain injury	10.1
10	encephalopathy	10.1
11	ocular motor apraxia	10.0
12	morphine dependence	10.0	FOS CREB1
13	cerebral artery occlusion	10.0
14	respiratory failure	10.0
15	cerebrovascular disease	10.0
16	intracranial hypertension	10.0
17	myoclonus	10.0
18	cerebral palsy	9.9
19	neuroblastoma 1	9.8
20	stroke, ischemic	9.8
21	hydrops, lactic acidosis, and sideroblastic anemia	9.8
22	visual epilepsy	9.8
23	status epilepticus	9.8
24	dystonia	9.8
25	seizure disorder	9.8
26	posttransplant acute limbic encephalitis	9.8
27	atherosclerosis susceptibility	9.7
28	migraine with or without aura 1	9.7
29	triiodothyronine receptor auxiliary protein	9.7
30	moyamoya disease 1	9.7
31	sudden infant death syndrome	9.7
32	body mass index quantitative trait locus 11	9.7
33	yemenite deaf-blind hypopigmentation syndrome	9.7
34	body mass index quantitative trait locus 9	9.7
35	body mass index quantitative trait locus 8	9.7
36	body mass index quantitative trait locus 4	9.7
37	body mass index quantitative trait locus 10	9.7
38	body mass index quantitative trait locus 7	9.7
39	diabetes mellitus, ketosis-prone	9.7
40	body mass index quantitative trait locus 12	9.7
41	body mass index quantitative trait locus 14	9.7
42	body mass index quantitative trait locus 18	9.7
43	chorea, childhood-onset, with psychomotor retardation	9.7
44	body mass index quantitative trait locus 19	9.7
45	body mass index quantitative trait locus 20	9.7
46	pulmonary hypertension	9.7
47	metabolic acidosis	9.7
48	focal dystonia	9.7
49	sleep apnea	9.7
50	post-cardiac arrest syndrome	9.7

Graphical network of the top 20 diseases related to Cerebral Hypoxia:

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Symptoms & Phenotypes for Cerebral Hypoxia

GenomeRNAi Phenotypes related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability with paclitaxel	GR00179-A-1	8.92	CASP3 IGF1 PTK2
2	Decreased viability with paclitaxel	GR00179-A-2	8.92	IGF1

MGI Mouse Phenotypes related to Cerebral Hypoxia:

⁴⁶ (show all 18)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.31	BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
2	growth/size/body region	MP:0005378	10.26	BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
3	endocrine/exocrine gland	MP:0005379	10.24	CAMK4 CASP3 CASP9 CREB1 FOS IGF1
4	cardiovascular system	MP:0005385	10.23	BCAR1 CASP3 CASP9 CREB1 IGF1 ITGAV
5	mortality/aging	MP:0010768	10.17	BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
6	hematopoietic system	MP:0005397	10.16	CAMK4 CASP3 CASP9 FOS IGF1 ITGAV
7	homeostasis/metabolism	MP:0005376	10.15	CAMK4 CASP3 CREB1 FOS IGF1 ITGAV
8	immune system	MP:0005387	10.13	CAMK4 CASP3 CASP9 FOS IGF1 ITGAV
9	embryo	MP:0005380	10.09	BCAR1 CASP9 CREB1 FOS ITGAV ITGB1
10	nervous system	MP:0003631	10.02	CAMK4 CASP3 CASP9 CREB1 FOS IGF1
11	muscle	MP:0005369	10.01	BCAR1 CASP3 CREB1 IGF1 ITGAV ITGB1
12	craniofacial	MP:0005382	9.96	CASP3 CASP9 FOS ITGAV ITGB1
13	integument	MP:0010771	9.93	CAMK4 CASP3 FOS IGF1 ITGB1 PTK2
14	normal	MP:0002873	9.8	CAMK4 CREB1 FOS IGF1 ITGB1 NOS1
15	neoplasm	MP:0002006	9.77	FOS IGF1 ITGAV ITGB1 PTK2
16	reproductive system	MP:0005389	9.76	CAMK4 CASP3 CREB1 FOS IGF1 ITGB1
17	respiratory system	MP:0005388	9.5	CASP3 CASP9 CREB1 IGF1 ITGB1 NOS1
18	skeleton	MP:0005390	9.17	CAMK4 CASP3 CREB1 FOS IGF1 ITGB1

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Drugs & Therapeutics for Cerebral Hypoxia

Drugs for Cerebral Hypoxia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Propofol

Approved, Investigational, Vet_approved

Phase 4

2078-54-8

4943

Sevoflurane

Approved, Vet_approved

Phase 4

28523-86-6

5206

Fentanyl

Approved, Illicit, Investigational, Vet_approved

Phase 4

437-38-7

3345

Epinephrine

Approved, Vet_approved

Phase 4

51-43-4

5816

Racepinephrine

Approved

Phase 4

329-65-7

838

Hypnotics and Sedatives

Phase 4

Anesthetics, Intravenous

Phase 4

Ether

Phase 4

Epinephryl borate

Phase 4

Mannitol

Approved, Investigational

Phase 3

69-65-8

453 6251

Allopurinol

Approved

Phase 3

315-30-0

2094

Creatine

Approved, Investigational, Nutraceutical

Phase 3

57-00-1

586

Antioxidants

Phase 3

Protective Agents

Phase 3

Antirheumatic Agents

Phase 3

Free Radical Scavengers

Phase 3

Natriuretic Agents

Phase 3

diuretics

Phase 3

Antimetabolites

Phase 3

Clonidine

Approved

Phase 1, Phase 2

4205-90-7

2803

Xenon

Experimental

Phase 2

7440-63-3

Central Nervous System Depressants

Phase 2

Anesthetics

Phase 2

Anesthetics, General

Phase 2

Anesthetics, Inhalation

Phase 2

Neurotransmitter Agents

Phase 1, Phase 2

Peripheral Nervous System Agents

Phase 1, Phase 2

Analgesics

Phase 1, Phase 2

Antihypertensive Agents

Phase 1, Phase 2

Adrenergic alpha-2 Receptor Agonists

Phase 1, Phase 2

Adrenergic Agonists

Phase 1, Phase 2

Adrenergic alpha-Agonists

Phase 1, Phase 2

Adrenergic Agents

Phase 1, Phase 2

Sympatholytics

Phase 1, Phase 2

Autonomic Agents

Phase 1, Phase 2

tannic acid

Approved

1401-55-4

Benzocaine

Approved, Investigational

94-09-7, 1994-09-7

2337

Resveratrol

Approved, Experimental, Investigational

501-36-0

445154

Desflurane

Approved

57041-67-5

42113

Temozolomide

Approved, Investigational

85622-93-1

5394

Dexmedetomidine

Approved, Vet_approved

113775-47-6

68602 5311068

Dobutamine

Approved

34368-04-2

36811

Dopamine

Approved

51-61-6, 62-31-7

681

Alprostadil

Approved, Investigational

745-65-3

5280723 149351

Glutamic acid

Approved, Nutraceutical

56-86-0

33032

Vitamin A

Approved, Nutraceutical, Vet_approved

22737-96-8, 11103-57-4, 68-26-8

9904001 445354

Platelet Aggregation Inhibitors

Analgesics, Non-Narcotic

Antineoplastic Agents, Phytogenic

Anti-Inflammatory Agents, Non-Steroidal

Interventional clinical trials:

(show top 50) (show all 58)

#	Name	Status	NCT ID	Phase	Drugs
1	Sevoflurane-based Volatile Induction and Maintenance of Anaesthesia (VIMA) Strategy Decreases the Risk of Postoperative Delirium in Elderly Patients With Registered Cerebral Hypoxemia Episodes During General Surgery	Unknown status	NCT02133638	Phase 4	Sevoflurane;Propofol
2	Does the Early Use of Sodium Bicarbonate Improve Results of Cardiopulmonary Resuscitation Following Out-of-Hospital Cardiac Arrest - a Prospective, Controlled Clinical Trial	Unknown status	NCT01377337	Phase 4	sodium bicarbonate
3	Hyperoxia: An Unrecognized Mechanism for Inducing "Hypoxia-Like" Symptoms	Completed	NCT03268590	Phase 4	Oxygen
4	Multicenter Double-blind Placebo-controlled Parallel-group Randomized Clinical Trial of Efficacy and Safety of Tenoten for Children Liquid Dosage Form Therapy in Infants With Sequelae of Perinatal Brain Injury	Completed	NCT03159611	Phase 3	Tenoten for children;Placebo
5	Randomized Controlled Trial of Hypothermia for Hypoxic-Ischemic Encephalopathy in Term Infants	Completed	NCT00005772	Phase 3
6	Evaluation of Systemic Hypothermia Initiated After 6 Hours of Age in Infants ≥36 Weeks Gestation With Hypoxic-Ischemic Encephalopathy: A Bayesian Evaluation. A Protocol for the NICHD Neonatal Research Network	Completed	NCT00614744	Phase 2, Phase 3
7	Creatine as a New Treatment for Schizophrenia:A Double-Blind Trial	Completed	NCT00140192	Phase 3	creatine
8	A Randomized Trial of Targeted Temperature Management With Whole Body Hypothermia For Moderate And Severe Hypoxic-Ischemic Encephalopathy In Premature Infants 33-35 Weeks Gestational Age.	Recruiting	NCT01793129	Phase 2, Phase 3
9	Effect of ALlopurinol in Addition to Hypothermia for Hypoxic-ischemic Brain Injury on Neurocognitive Outcome - a Blinded Randomized Placebo-controlled Parallel Group Multicenter Trial for Superiority (Phase III)	Recruiting	NCT03162653	Phase 3	Allopurinol;Mannitol
10	Transfusion Strategies in Acute Brain Injured Patients. A Prospective Multicenter Randomized Study.	Recruiting	NCT02968654	Phase 3
11	Optimizing Cooling Strategies at < 6 Hours of Age for Neonatal Hypoxic-Ischemic Encephalopathy	Terminated	NCT01192776	Phase 3
12	Neuroplasticity of Brain-Asphyxiated Infants: Efficacy of Intervention	Completed	NCT00006516	Phase 2
13	Anesthesia vs Aviation: Does Added Carbon Dioxide in Normobaric Hypoxia Have the Same Effect on Cerebral Oxygenation as in Hypobaric Hypoxia?	Completed	NCT03338907	Phase 2	Oxycarbon (5% CO2+ 95% O2)
14	Phase 2 Study of Effect of Xenon, in Combination With Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest Patients	Completed	NCT00879892	Phase 2	xenon
15	Phase I-II Clinical Trial to Determine the Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia	Completed	NCT01862250	Phase 1, Phase 2	Clonidine (Duraclon®)
16	Role of Cerebral Blood Flow on Ventilatory Stability During Sleep in Normoxia and Intermittent Hypoxia	Not yet recruiting	NCT03255408	Phase 1, Phase 2	Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep;Drug Lowering CBF and Intermittent Hypoxia Sleep;Placebo and Normoxia Sleep;Placebo and Intermittent Hypoxia Sleep
17	The Difference in Cerebral Oxygenation Between Propofol and Sevoflurane	Completed	NCT01757561
18	Perioperative Interventions to Optimize Cerebral Oxygen Saturation (rSO2) in High-risk Patients Undergoing Cardiac Surgery Should Have a Beneficial Systemic Effect for Enhancing Global Tissue Perfusion and Improve Outcomes.	Completed	NCT01432184
19	The Effects of Hypobaria vs Hypoxia on Cerebral Vasoreactivity, Brain's Electrical Activity and Concentration Performance on Pilots.	Completed	NCT03303118
20	Assessment of Tele-expertise for the Interpretation of MRI Among Neonates With High Risk of Neurological Sequelae	Completed	NCT03706651
21	Pilot Trial Concerning Glutamate Elimination With CRRT for Neurological Outcome After Cardiac Arrest	Completed	NCT02963298
22	Septic Shock and Delirium Because of rSO2 Abnormalities in Intensive Care Unit Patients (The SAD BRAIN Study)	Completed	NCT01836302
23	Near Infrared Spectroscopy in Aortic Valve Replacement	Completed	NCT01251328
24	The Impact of a Beach Chair Position During Shoulder Arthroscopy on Regional Cerebral Oxygen Saturation : Comparison of Interscalene Block and General Anesthesia	Completed	NCT02605005
25	Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia	Completed	NCT02482571
26	Oxygenation of the Neonatal Brain - a Study Using the INVOS Oximeter	Completed	NCT01690650		Oxygen
27	Oxygenation of the Neonatal Brain - a Study Using the INVOS Oximeter	Completed	NCT01684618
28	Effects of High Inspiratory Oxygen on Cerebral Tissue Oxygenation and Patient Recovery After Carotid Endarterectomy	Completed	NCT02991976
29	Postoperative Delirium in Patients Undergoing Hip Arthroplasty	Completed	NCT02323984
30	A Multicentre Prospective Study on Magnetic Resonance Biomarkers in Neonatal Encephalopathy	Completed	NCT01309711
31	The Effects of Acute Trans-resveratrol Supplementation on Aspects of Cognitive Function and Cerebral Blood Flow, During Hypoxia and Normoxia, in Healthy, Young Humans.	Completed	NCT03100019		Placebo
32	Comparison of Low Versus Normal Flow Anesthesia on Cerebral Oxygenation and Bispectral Index in Morbidly Obese Patients Undergoing Sleeve Gastrectomy: Prospective, Randomized Clinical Trial	Completed	NCT03438734
33	Retrospective Evaluation of Prognostic and/or Predictive Profile of Melanocortin Receptor-4 Gene Polymorphisms in Patient With a Diagnosis of Glioblastoma Treated With Upfront Concomitant Radio-chemotherapy or Chemotherapy	Completed	NCT02458508
34	Evaluation of the Cerebral Responses to Exercise in Hypoxia	Completed	NCT01614119
35	Brain-computer Interface in the Diagnosis of Disorders of Consciousness	Completed	NCT03998930
36	EARLY TRACHEOSTOMY VERSUS STANDARD OF CARE, A RANDOMIZED CONTROLLED CLINICAL TRIAL IN PATIENTS WITH SEVERE HEAD INJURY IN MULAGO HOSPITAL	Completed	NCT02442154
37	Hypoxia and Outcome Prediction in Early Stage Coma: Towards an Improvement of Clinical and Electrophysiological Predictors	Completed	NCT02231060
38	Optimizing Cerebral Oxygenation in Cardiac Surgery	Completed	NCT01539382
39	BiHiVE 2 Study. The Investigation and Validation of Predictive Biomarkers in Hypoxic-ischaemic Encephalopathy.	Completed	NCT02019147
40	Validation of the Predictive Value of the FORE-SIGHT™ Monitor for Early Detection of Hemodynamic Deterioration After Pediatric Cardiac Surgery. A Data-mining Study.	Completed	NCT01706497
41	NeoAdapt 3: An Observational Study Investigating Novel Biomarkers in the Evaluation and Treatment of Neonatal Circulatory Insufficiency in Infants Suffering From Hypoxic Ischemic Encephalopathy.	Completed	NCT02051894		Dobutamine
42	Impact of Early Optimization of Brain Oxygenation on Neurological Outcome After Severe Traumatic Brain Injury	Recruiting	NCT02754063
43	Correlating Brain Tissue Oxygen Tension (PbrO2) and Regional Cerebral Oximetry (rSO2) in Normal Human Brain Under the Conditions of Changing Ventilation Strategy	Recruiting	NCT03128957
44	TAME Cardiac Arrest Trial: Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest: A Phase III Multi-Centre Randomised Controlled Trial	Recruiting	NCT03114033
45	Cerebral Regional Tissue Oxygen Saturation to Guide Oxygen Delivery in Preterm Neonates During Immediate Transition After Birth: An Investigator-initiated Randomised Multi-centre Multinational Clinical Trial	Recruiting	NCT03166722
46	Predicting Neurological Outcome Following Out of Hospital Cardiac Arrest (OHCA) by Quantitative Measurement of Serial Serum Biomarkers of Brain Injury.	Recruiting	NCT03112486
47	Neuroprotective Role of Lactate Therapy in Humans With Traumatic Brain Injury	Recruiting	NCT01573507
48	Safety, Tolerability, and Early Efficacy of Immersive Virtual Reality for Early Neurocognitive Stimulation in the Intensive Care Unit.	Recruiting	NCT03569358
49	Impact of Obstructive Sleep Apnea in the Evolution of Alzheimer Disease. Role of Hypoxia and Sleep Fragmentation	Recruiting	NCT02814045
50	Multimodal Monitoring of Hemodynamics in Extremely Low Birth Weight Preterm Infant in a Canadian Tertiary Level Unit- Non-Blinded Randomized Control Trial	Recruiting	NCT03841929

Search NIH Clinical Center for Cerebral Hypoxia

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Genetic Tests for Cerebral Hypoxia

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Anatomical Context for Cerebral Hypoxia

MalaCards organs/tissues related to Cerebral Hypoxia:

⁴¹

Brain, Cortex, Heart, Endothelial, Testes, Kidney, Cerebellum

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Publications for Cerebral Hypoxia

Articles related to Cerebral Hypoxia:

(show top 50) (show all 1638)

#	Title	Authors	PMID	Year
1	Effect of hypoxia on the expression of procaspase-9 and procaspase-3 in neuronal nuclear, mitochondrial and cytosolic fractions of the cerebral cortex of newborn piglets. ⁹ ³⁸	Delivoria-Papadopoulos M...Mishra OP	18468794	2008
2	ATP and cytochrome c-dependent activation of caspase-9 during hypoxia in the cerebral cortex of newborn piglets. ⁹ ³⁸	Delivoria-Papadopoulos M...Mishra OP	17976908	2007
3	Differential expression of apoptotic proteins following hypoxia-induced CREB phosphorylation in the cerebral cortex of newborn piglets. ⁹ ³⁸	Delivoria-Papadopoulos M...Mishra OP	17401658	2007
4	Mechanism of activation of caspase-9 and caspase-3 during hypoxia in the cerebral cortex of newborn piglets: the role of nuclear Ca2+ -influx. ⁹ ³⁸	Delivoria-Papadopoulos M...Mishra OP	17268855	2007
5	Hypoxia-induced Bax and Bcl-2 protein expression, caspase-9 activation, DNA fragmentation, and lipid peroxidation in mitochondria of the cerebral cortex of newborn piglets: the role of nitric oxide. ⁹ ³⁸	Mishra OP...Delivoria-Papadopoulos M	16777344	2006
6	Effect of 7-nitroindazole sodium on the cellular distribution of neuronal nitric oxide synthase in the cerebral cortex of hypoxic newborn piglets. ⁹ ³⁸	Katsetos CD...Mishra OP	16804757	2006
7	Effect of neuronal nitric oxide synthase inhibition on caspase-9 activity during hypoxia in the cerebral cortex of newborn piglets. ⁹ ³⁸	Mishra OP...Delivoria-Papadopoulos M	16545906	2006
8	Anaemia and the brain. ⁹ ³⁸	Hare GM	17023891	2004
9	Effect of hypoxia on protein phosphatase 2A activity, subcellular distribution and expression in cerebral cortex of newborn piglets. ⁹ ³⁸	Truttmann AC...Delivoria-Papadopoulos M	15262326	2004
10	Effects of novel hexahydropyrimidine derivatives as potential ligands of M1 muscarinic acetylcholine receptor on cognitive function, hypoxia-induced lethality, and oxidative stress in rodents. ³⁸	Sapozhnikova TA...Zarudii FS	31340175	2019
11	Suppression of PDGF induces neuronal apoptosis after neonatal cerebral hypoxia and ischemia by inhibiting P-PI3K and P-AKT signaling pathways. ³⁸	Xiong LL...Wang TH	31082354	2019
12	Intra- and interdialytic cerebral hypoxia: A culprit of cognitive decline going unpunished? ³⁸	Kovarova L...Malik J	31034688	2019
13	Effect of nitrite on the electroencephalographic activity in the healthy brain. ³⁸	Franko E...Pattinson K	31254718	2019
14	Continuous EEG monitoring after brain tumor surgery. ³⁸	Elf K...Zetterling M	31278599	2019
15	Redox-Dependent Loss of Flavin by Mitochondrial Complex I in Brain Ischemia/Reperfusion Injury. ³⁸	Stepanova A...Galkin A	31037949	2019
16	LncRNA-ROR is involved in cerebral hypoxia/reoxygenation-induced injury via regulating miR-135a-5p/ROCK1/2. ³⁸	Chen H...Li X	31419405	2019
17	A case report of unusual clinical features of a spontaneous coronary artery rupture: pathologic findings in the rupture site. ³⁸	Fujimoto D...Shite J	31384915	2019
18	In chronic hypoxia, glucose availability and hypoxic severity dictate the balance between HIF-1 and HIF-2 in astrocytes. ³⁸	Guo M...Zhao Y	31298941	2019
19	Limitations of near infrared spectroscopy (NIRS) in neurosurgical setting: our case experience. ³⁸	Ajayan N...Hrishi AP	30315489	2019
20	The Burden of Brain Hypoxia and Optimal Mean Arterial Pressure in Patients With Hypoxic Ischemic Brain Injury After Cardiac Arrest. ³⁸	Sekhon MS...Griesdale DEG	30889022	2019
21	Conventional and functional magnetic resonance imaging features of late subacute cortical laminar necrosis in a dog. ³⁸	Alisauskaite N...Beckmann K	31120629	2019
22	Nitric oxide donor molsidomine favors features of atherosclerotic plaque stability and reduces myocardial infarction in mice. ³⁸	Roth L...De Meyer GRY	31085310	2019
23	Cerebral perfusion and assessing hemodynamic significance for patent ductus arteriosus using near infrared red spectroscopy in very low birth weight infants. ³⁸	Poon WB...Tagamolila V	31303077	2019
24	FGF21 promotes functional recovery after hypoxic-ischemic brain injury in neonatal rats by activating the PI3K/Akt signaling pathway via FGFR1/β-klotho. ³⁸	Ye L...Lin Z	30802446	2019
25	Echinacoside Alleviates Hypoxic-Ischemic Brain Injury in Neonatal Rat by Enhancing Antioxidant Capacity and Inhibiting Apoptosis. ³⁸	Wei W...Yu JQ	30911982	2019
26	Continuous Near-Infrared Spectroscopy Monitoring in Adult Traumatic Brain Injury: A Systematic Review. ³⁸	Mathieu F...Zeiler FA	31306264	2019
27	Angioneurins - Key regulators of blood-brain barrier integrity during hypoxic and ischemic brain injury. ³⁸	Kunze R...Marti HH	30970273	2019
28	Exposure Duration and History of Hypertension Predicted Neurological Sequelae in Patients with Carbon Monoxide Poisoning. ³⁸	Huang CC...Guo HR	31181009	2019
29	Impact of inflammation on brain subcellular energetics in anesthetized rats. ³⁸	Thiele RH...Zuo Z	31307382	2019
30	Clinical Usefulness of Transcranial Doppler as a Screening Tool for Early Cerebral Hypoxic Episodes in Patients with Moderate and Severe Traumatic Brain Injury. ³⁸	Sokoloff C...ERESI Reseach Group (Equipe de Recherche En Soins Intensifs)	31218643	2019
31	Burden of hypoxia and intraventricular haemorrhage in extremely preterm infants. ³⁸	Ng IHX...Austin T	31256012	2019
32	Factors responsible for cerebral hypoxia in hemodialysis population. ³⁸	Valerianova A...Malik J	31177793	2019
33	Respiratory depression and brain hypoxia induced by opioid drugs: Morphine, oxycodone, heroin, and fentanyl. ³⁸	Kiyatkin EA	30735692	2019
34	Interactions of benzodiazepines with heroin: Respiratory depression, temperature effects, and behavior. ³⁸	Afzal A...Kiyatkin EA	31228487	2019
35	Thyroid Hormone Protects Primary Cortical Neurons Exposed to Hypoxia By Reducing DNA Methylation and Apoptosis. ³⁸	Li J...Brent GA	31095291	2019
36	Brain wave disturbance and cognitive impairment after CPR. ³⁸	Jand Y...Dehpour AR	31010488	2019
37	Validation of a Second-Generation Near-Infrared Spectroscopy Monitor in Children With Congenital Heart Disease. ³⁸	Nasr VG...Kussman BD	29324491	2019
38	Thoracic endovascular aortic repair for the treatment of ruptured acute type B aortic dissection. ³⁸	Chino S...Sakuma H	30712166	2019
39	Protective effect of troxerutin and cerebroprotein hydrolysate injection on cerebral ischemia through inhibition of oxidative stress and promotion of angiogenesis in rats. ³⁸	Ma W...Feng W	30816516	2019
40	HIF1α Signaling in the Endogenous Protective Responses after Neonatal Brain Hypoxia-Ischemia. ³⁸	Liang X...Ferriero DM	30836371	2019
41	Hypoxia Induces Astrocyte-Derived Lipocalin-2 in Ischemic Stroke. ³⁸	Ranjbar Taklimie F...Zendedel A	30871254	2019
42	Cerebral regional tissue Oxygen Saturation to Guide Oxygen Delivery in preterm neonates during immediate transition after birth (COSGOD III): an investigator-initiated, randomized, multi-center, multi-national, clinical trial on additional cerebral tissue oxygen saturation monitoring combined with defined treatment guidelines versus standard monitoring and treatment as usual in premature infants during immediate transition: study protocol for a randomized controlled trial. ³⁸	Pichler G...Schmolzer GM	30894226	2019
43	Oxygen-Glucose Deprivation/Reoxygenation-Induced Barrier Disruption at the Human Blood-Brain Barrier is Partially Mediated Through the HIF-1 Pathway. ³⁸	Page S...Al-Ahmad A	30911877	2019
44	Detection of Brain Hypoxia Based on Noninvasive Optical Monitoring of Cerebral Blood Flow with Diffuse Correlation Spectroscopy. ³⁸	Busch DR...Kofke WA	30030667	2019
45	Migrainous Infarction in a Patient With Sporadic Hemiplegic Migraine and Cystic Fibrosis: A 99mTc-HMPAO Brain SPECT Study. ³⁸	Mancini V...Di Piero V	30620050	2019
46	Cerebral malaria. ³⁸	Luzolo AL...Ngoyi DM	30658131	2019
47	Tonic electromyographic activity following bilateral tonic-clonic seizures is associated with periictal respiratory dysfunction and postictal generalized EEG suppression. ³⁸	Park KJ...Seyal M	30630218	2019
48	Further options and survival results after failure following extracorporeal life support implantation. ³⁸	Rupprecht L...Keyser A	29616522	2019
49	No neurodevelopmental benefit of cerebral oximetry in the first randomised trial (SafeBoosC II) in preterm infants during the first days of life. ³⁸	Plomgaard AM...Greisen G	29908039	2019
50	Haemodynamic Instability and Brain Injury in Neonates Exposed to Hypoxia⁻Ischaemia. ³⁸	Badurdeen S...Polglase G	30818842	2019

Sources

Genes for Cerebral Hypoxia

Genes related to Cerebral Hypoxia (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CAMK4	Calcium/Calmodulin Dependent Protein Kinase IV	Protein Coding	17.16	Novoseek inferred ⁵⁵	15262326
2	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	16.37	GeneCards inferred via : Publications (show sections)
3	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	16.37	GeneCards inferred via : Publications (show sections)
4	IGF1	Insulin Like Growth Factor 1	Protein Coding	16.37	GeneCards inferred via : Publications (show sections)
5	ITGAV	Integrin Subunit Alpha V	Protein Coding	16.37	GeneCards inferred via : Publications (show sections)
6	ITGB1	Integrin Subunit Beta 1	Protein Coding	16.37	GeneCards inferred via : Publications (show sections)
7	CASP9	Caspase 9	Protein Coding	15.38	Novoseek inferred ⁵⁵	17268855 16777344 17976908 (more) 18468794 16545906
8	NOS1	Nitric Oxide Synthase 1	Protein Coding	14.39	Novoseek inferred ⁵⁵	17023891 16804757
9	CASP3	Caspase 3	Protein Coding	13.95	Novoseek inferred ⁵⁵	17268855 17976908
10	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	12.04	Novoseek inferred ⁵⁵	17401658
11	PTK2	Protein Tyrosine Kinase 2	Protein Coding	6.37	GeneCards inferred via : Publications (show sections)

Sources

Variations for Cerebral Hypoxia

Sources

Expression for Cerebral Hypoxia

Search GEO for disease gene expression data for Cerebral Hypoxia.

Sources

Pathways for Cerebral Hypoxia

Pathways related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

(show top 50) (show all 113)

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by GPCR ⁶⁶ Show member pathways GPCR downstream signaling ⁶⁶ Signal Transduction ⁶⁶	14.09	PTK2 ITGB1 ITGAV IGF1 CREB1 CASP9
2	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.94	PTK2 NOS1 ITGB1 ITGAV FOS CREB1
3	Apoptotic Pathways in Synovial Fibroblasts ⁶⁴ Show member pathways Actin-Based Motility by Rho Family GTPases ⁶⁴ Cellular Apoptosis Pathway ⁶⁴ DHA Signaling ⁶⁴ eIF2 Pathway ⁶⁴ ERK5 Signaling ⁶⁴ Glioma Invasiveness ⁶⁴ Mitochondrial Apoptosis ⁶⁴ Nuclear Receptor Activation by Vitamin-A ⁶⁴ p53 Mediated Apoptosis ⁶⁴ PPAR Pathway ⁶⁴ Rac1 Pathway ⁶⁴ Rap1 Pathway ⁶⁴ Telomerase Components in Cell Signaling ⁶⁴	13.8	PTK2 ITGB1 ITGAV IGF1 FOS CREB1
4	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.76	PTK2 ITGB1 ITGAV IGF1 FOS CREB1
5	GPCR Pathway ⁶⁴ Show member pathways Breast Cancer Regulation by Stathmin1 ⁶⁴ Estrogen Pathway ⁶⁴ NFAT in Immune Response ⁶⁴ P2Y Receptor Signaling ⁶⁴ Pancreatic Adenocarcinoma ⁶⁴ Paxillin Interactions ⁶⁴ Ras Pathway ⁶⁴	13.65	PTK2 ITGB1 ITGAV IGF1 FOS CREB1
6	Integrin Pathway ⁶⁴ Show member pathways FAK1 Signaling ⁶⁴ GnRH Signaling ⁶⁴ Inhibition of Angiogenesis by TSP1 ⁶⁴ Transendothelial Migration of Leukocytes ⁶⁴ UPA-UPAR Pathway ⁶⁴	13.35	PTK2 ITGB1 ITGAV FOS CREB1 CASP3
7	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.33	PTK2 ITGB1 ITGAV IGF1 FOS CREB1
8	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet activation, signaling and aggregation ⁶⁶ Platelet degranulation ⁶⁶	13.27	PTK2 NOS1 ITGB1 ITGAV IGF1 BCAR1
9	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.24	PTK2 IGF1 FOS CASP9 CASP3
10	Phospholipase-C Pathway ⁶⁴ Show member pathways PTEN Pathway ⁶⁴	13	PTK2 ITGB1 ITGAV IGF1 CREB1 CAMK4
11	fMLP Pathway ⁶⁴ Show member pathways Alpha-Adrenergic Signaling ⁶⁴ CCR3 Pathway in Eosinophils ⁶⁴ CXCR4 Pathway ⁶⁴ Huntington's Disease Pathway ⁶⁴ Internalin Pathway ⁶⁴ Signal transduction Activation of PKC via G-Protein coupled receptor ²² VEGF and S-1P Signaling ⁶⁴	12.99	PTK2 IGF1 FOS CASP3 CAMK4 BCAR1
12	Actin Nucleation by ARP-WASP Complex ⁶⁴ Show member pathways Actin Nucleation and Branching ⁶⁴ CDC42 Pathway ⁶⁴ RhoA Pathway ⁶⁴	12.96	PTK2 ITGB1 ITGAV IGF1 FOS
13	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.93	PTK2 ITGB1 ITGAV IGF1 CREB1 CASP9
14	Sertoli-Sertoli Cell Junction Dynamics ⁶⁴ Show member pathways Epithelial Tight Junctions ⁶⁴ Germ Cell-Sertoli Cell Junction Dynamics ⁶⁴	12.9	PTK2 NOS1 ITGB1 ITGAV FOS BCAR1
15	Human cytomegalovirus infection ³⁷ Show member pathways Human immunodeficiency virus 1 infection ³⁷ Kaposi sarcoma-associated herpesvirus infection ³⁷	12.9	PTK2 ITGAV FOS CREB1 CASP9 CASP3
16	Regulation of lipid metabolism Insulin signaling-generic cascades ²² Show member pathways acetyl-CoA biosynthesis from citrate ¹ Butyrate-induced histone acetylation ¹ Cell adhesion PLAU signaling ²² Class IB PI3K non-lipid kinase events ¹ Development CNTF receptor signaling ²² Development Growth hormone signaling via PI3K/AKT and MAPK cascades ²² ErbB2/ErbB3 signaling events ¹ Glucose Homeostasis ¹ Insulin signaling pathway ³⁷ IRS activation ⁶⁶ Signal attenuation ⁶⁶ Transcription Receptor-mediated HIF regulation ²² Translation Regulation of EIF2 activity ²² Translation Regulation of EIF4F activity ²² Translation Insulin regulation of translation ²²	12.88	PTK2 ITGB1 IGF1 FOS BCAR1
17	Focal Adhesion ³⁷ ¹ Show member pathways HGF Pathway ⁶⁴ Integrin-mediated Cell Adhesion ¹	12.87	PTK2 ITGB1 ITGAV IGF1 FOS BCAR1
18	Allograft rejection ³⁷ ¹ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.83	FOS CREB1 CASP9 CASP3
19	NFAT and Cardiac Hypertrophy ⁶⁴ Show member pathways IGF1R Signaling ⁶⁴ Signaling Involved in Cardiac Hypertrophy ⁶⁴	12.81	PTK2 ITGB1 ITGAV IGF1 CREB1 CASP9
20	MAPK-Erk Pathway ⁶⁷ Show member pathways Actin Dynamics Signaling Pathway ⁶⁷ G Protein-coupled Receptors Signaling ⁶⁷	12.79	PTK2 ITGB1 ITGAV FOS CREB1 CAMK4
21	TNFR1 Pathway ⁶⁴ Show member pathways Apoptosis and survival TNFR1 signaling pathway ²² Apoptosis through Death Receptors ⁶⁴ Apoptotic Pathways Triggered By HIV1 ⁶⁴ DR3 Signaling ⁶⁴ Fas Signaling ⁶⁴ GITR Pathway ⁶⁴ HIV-1 Nef- Negative effector of Fas and TNF-alpha ¹ Stimulation of the cell death response by PAK-2p34 ⁶⁶ TNF alpha Signaling Pathway ¹ TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway ¹ TNF Signaling ⁶⁴ TRAIL Pathway ⁶⁴ TWEAK Pathway ⁶⁴	12.79	PTK2 ITGB1 IGF1 FOS CASP9 CASP3
22	Apoptosis Modulation and Signaling ¹ Show member pathways Apoptosis ³⁷ Apoptosis ¹ Apoptosis and survival Apoptotic TNF-family pathways ²² Apoptosis Signaling Pathways ⁶⁵ Death Receptor Signaling ⁶⁷	12.77	IGF1 FOS CASP9 CASP3
23	Pathways in cancer ³⁷	12.76	PTK2 ITGB1 ITGAV IGF1 FOS CASP9
24	MAPK signaling pathway ³⁷ ¹	12.73	IGF1 FOS CASP9 CASP3
25	Glioma ³⁷ Show member pathways Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.66	PTK2 IGF1 FOS CASP9
26	4-1BB Pathway ⁶⁴ Show member pathways CD27 Pathway ⁶⁴ CD40 Signaling ⁶⁴ CMV and MAPK Pathways ⁶⁴ NF-KappaB Activation by EBV ⁶⁴ NF-kappaB Activation by Viruses ⁶⁴ PKR Pathway ⁶⁴ SUMO Pathway ⁶⁴ TNFR2 Pathway ⁶⁴	12.65	FOS CREB1 CASP9 CASP3
27	DREAM Repression and Dynorphin Expression ⁶⁴ Show member pathways BMP Pathway ⁶⁴ Calpain Protease Regulates Cellular Mechanics ⁶⁴ Caspase Cascade ⁶⁴ Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels ⁶⁶ nNOS Signaling in Skeletal Muscle ⁶⁴ TOB in Osteoblast Signaling ⁶⁴	12.61	NOS1 FOS CREB1 CASP9 CASP3 CAMK4
28	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases ²² Show member pathways Cell adhesion Integrin-mediated cell adhesion and migration ²² Cell adhesion Tight junctions ²² Cytoskeleton remodeling Integrin outside-in signaling ²² Development MAG-dependent inhibition of neurite outgrowth ²²	12.6	PTK2 ITGB1 ITGAV BCAR1
29	Regulation of actin cytoskeleton ³⁷ ¹	12.6	PTK2 ITGB1 ITGAV BCAR1
30	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.59	PTK2 NOS1 ITGB1 FOS CASP9
31	Development Dopamine D2 receptor transactivation of EGFR ²² Show member pathways Apoptosis and survival BAD phosphorylation ²² BAD Phosphorylation ⁶⁴ Chemotaxis CXCR4 signaling pathway ²² Development Alpha-2 adrenergic receptor activation of ERK ²²	12.55	PTK2 IGF1 CASP9 BCAR1
32	Myometrial Relaxation and Contraction Pathways ¹ Show member pathways Calcium Regulation in the Cardiac Cell ¹	12.52	NOS1 FOS CREB1 CAMK4
33	TRAF Pathway ⁶⁴ Show member pathways 14-3-3 Induced Apoptosis ⁶⁴ TNF Superfamily Pathway ⁶⁴ Toll-Like Receptors Pathway ⁶⁴	12.51	ITGB1 ITGAV FOS CREB1 CASP9 CASP3
34	Development Endothelin-1/EDNRA signaling ²² Show member pathways Cytoskeleton remodeling FAK signaling ²² Development Endothelin-1/EDNRA transactivation of EGFR ²² GnRH signaling pathway ³⁷ Inflammatory mediator regulation of TRP channels ³⁷	12.5	PTK2 ITGB1 IGF1 FOS CASP9 CASP3
35	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.5	PTK2 ITGB1 IGF1 FOS CREB1 CASP9
36	Prolactin Signaling Pathway ¹ ³⁷ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	12.48	PTK2 ITGB1 FOS CREB1 CASP3
37	Apoptosis Pathway ⁷¹ Show member pathways Akt Pathway ⁷¹ NF-kappaB Pathway ⁷¹	12.44	PTK2 ITGB1 ITGAV CASP9 CASP3
38	MET promotes cell motility ⁶⁶ Show member pathways Alpha 6 Beta 4 signaling pathway ¹ Laminin interactions ⁶⁶ MET activates PTK2 signaling ⁶⁶ MET activates RAP1 and RAC1 ⁶⁶ MET activates RAS signaling ⁶⁶ MET interacts with TNS proteins ⁶⁶ MET Receptor Activation ⁶⁶ MET receptor recycling ⁶⁶ Non-integrin membrane-ECM interactions ⁶⁶ Signaling by MET ⁶⁶ Syndecan interactions ⁶⁶	12.43	PTK2 ITGB1 ITGAV
39	Development VEGF signaling via VEGFR2 - generic cascades ²² Show member pathways Development VEGF signaling and activation ²² VEGF - VEGF R2 Signaling Pathways ⁶⁵	12.4	PTK2 ITGAV FOS CREB1 CASP9
40	Development IGF-1 receptor signaling ²² Show member pathways IL-4 Signaling Pathway ¹ Immune response IL-4 signaling pathway ²² Signal transduction AKT signaling ²²	12.39	IGF1 FOS CREB1 CASP9
41	DNA Damage Response ¹ Show member pathways miRNA Regulation of DNA Damage Response ¹ p53 signaling pathway ³⁷	12.38	IGF1 CREB1 CASP9 CASP3
42	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ¹	12.38	ITGB1 ITGAV IGF1 FOS BCAR1
43	Proteoglycans in cancer ³⁷	12.31	PTK2 ITGB1 ITGAV IGF1 CASP3
44	B Cell Receptor Signaling Pathway (sino) ⁶⁷ Show member pathways B Cell Receptor Signaling Pathway ⁶⁷	12.29	FOS CREB1 CAMK4
45	cAMP signaling pathway ³⁷	12.29	FOS CREB1 CAMK4
46	Development Ligand-independent activation of ESR1 and ESR2 ²² Show member pathways Transcription CREB pathway ²² Transcription PPAR Pathway ²²	12.28	IGF1 CREB1 CAMK4
47	Toxoplasmosis ³⁷ Show member pathways Leishmaniasis ³⁷	12.26	ITGB1 FOS CASP9 CASP3
48	G-protein signaling Ras family GTPases in kinase cascades (scheme) ²² Show member pathways Activation of the AP-1 family of transcription factors ⁶⁶ Immune response Oncostatin M signaling via MAPK in human cells ²² MAPK Cascade ¹ Oncostatin M Signaling Pathway ¹	12.22	FOS CREB1 CASP3
49	Dilated cardiomyopathy (DCM) ³⁷ Show member pathways Hypertrophic cardiomyopathy (HCM) ³⁷	12.22	ITGB1 ITGAV IGF1
50	p53 Signaling ⁶⁴ Show member pathways p53 Pathway ⁶⁷	12.22	FOS CASP9 CASP3

Sources

GO Terms for Cerebral Hypoxia

Cellular components related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lamellipodium	GO:0030027	9.43	PTK2 ITGB1 BCAR1
2	dendritic spine	GO:0043197	9.33	PTK2 NOS1 ITGB1
3	integrin complex	GO:0008305	9.32	ITGB1 ITGAV
4	focal adhesion	GO:0005925	9.26	PTK2 ITGB1 ITGAV BCAR1
5	alphav-beta3 integrin-IGF-1-IGF1R complex	GO:0035867	8.62	ITGAV IGF1

Biological processes related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

(show all 28)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:0008284	9.92	PTK2 ITGB1 ITGAV IGF1
2	positive regulation of transcription, DNA-templated	GO:0045893	9.88	NOS1 IGF1 FOS CREB1 CAMK4
3	extracellular matrix organization	GO:0030198	9.81	PTK2 ITGB1 ITGAV
4	cell migration	GO:0016477	9.81	ITGB1 ITGAV BCAR1
5	positive regulation of apoptotic process	GO:0043065	9.8	ITGB1 CREB1 CASP9 CASP3
6	aging	GO:0007568	9.78	FOS CREB1 CASP9
7	response to hypoxia	GO:0001666	9.77	NOS1 CREB1 CASP3
8	positive regulation of cell migration	GO:0030335	9.71	PTK2 ITGAV IGF1 BCAR1
9	response to organic cyclic compound	GO:0014070	9.7	FOS CASP9 CASP3
10	response to antibiotic	GO:0046677	9.63	CASP9 CASP3
11	ERK1 and ERK2 cascade	GO:0070371	9.62	ITGAV IGF1
12	response to lipopolysaccharide	GO:0032496	9.62	NOS1 FOS CASP9 CASP3
13	heterotypic cell-cell adhesion	GO:0034113	9.61	ITGB1 ITGAV
14	vascular endothelial growth factor receptor signaling pathway	GO:0048010	9.61	PTK2 ITGAV BCAR1
15	positive regulation of cardiac muscle hypertrophy	GO:0010613	9.6	PTK2 IGF1
16	cell adhesion mediated by integrin	GO:0033627	9.58	ITGB1 ITGAV
17	positive regulation of osteoclast differentiation	GO:0045672	9.58	FOS CREB1
18	neurotrophin TRK receptor signaling pathway	GO:0048011	9.57	CASP3 BCAR1
19	platelet formation	GO:0030220	9.56	CASP9 CASP3
20	cell-substrate adhesion	GO:0031589	9.55	ITGB1 ITGAV
21	negative regulation of anoikis	GO:2000811	9.54	PTK2 ITGB1
22	cellular response to hepatocyte growth factor stimulus	GO:0035729	9.51	CREB1 BCAR1
23	response to cobalt ion	GO:0032025	9.46	CASP9 CASP3
24	glial cell apoptotic process	GO:0034349	9.37	CASP9 CASP3
25	extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	9.33	ITGAV CASP9 CASP3
26	leukocyte apoptotic process	GO:0071887	9.26	CASP9 CASP3
27	transforming growth factor beta receptor signaling pathway	GO:0007179	9.26	PTK2 ITGB1 FOS CREB1
28	integrin-mediated signaling pathway	GO:0007229	8.92	PTK2 ITGB1 ITGAV BCAR1

Molecular functions related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integrin binding	GO:0005178	9.5	ITGB1 ITGAV IGF1
2	coreceptor activity	GO:0015026	9.4	ITGB1 ITGAV
3	fibronectin binding	GO:0001968	9.37	ITGB1 ITGAV
4	protease binding	GO:0002020	9.33	ITGB1 ITGAV CASP3
5	cysteine-type endopeptidase activity involved in apoptotic process	GO:0097153	9.26	CASP9 CASP3
6	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	GO:0097199	8.96	CASP9 CASP3
7	C-X3-C chemokine binding	GO:0019960	8.62	ITGB1 ITGAV

Sources

Sources for Cerebral Hypoxia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ TGDB

⁷¹ Tocris

⁷² UMLS

⁷³ UMLS via Orphanet

⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia