MCID: CRB090
MIFTS: 42

Cerebral Hypoxia

Categories: Neuronal diseases

Aliases & Classifications for Cerebral Hypoxia

MalaCards integrated aliases for Cerebral Hypoxia:

Name: Cerebral Hypoxia 53 54
Brain Hypoxia 71

Classifications:



External Ids:

UMLS 71 C1527348

Summaries for Cerebral Hypoxia

NINDS : 53 Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.  In brain death, there is no measurable activity in the brain, although cardiovascular function is preserved. Life support is required for respiration.

MalaCards based summary : Cerebral Hypoxia, also known as brain hypoxia, is related to brain injury and traumatic brain injury. An important gene associated with Cerebral Hypoxia is CAMK4 (Calcium/Calmodulin Dependent Protein Kinase IV), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Fentanyl and Ether have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and endothelial, and related phenotypes are Increased viability with paclitaxel and cellular

Wikipedia : 74 Cerebral hypoxia is a form of hypoxia (reduced supply of oxygen), specifically involving the brain; when... more...

Related Diseases for Cerebral Hypoxia

Diseases related to Cerebral Hypoxia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 brain injury 30.2 IGF1 CASP3
2 traumatic brain injury 30.1 IGF1 CASP3
3 ocular dominance 29.5 NOS1 CREB1
4 asphyxia neonatorum 29.2 NOS1 CASP3
5 neuroblastoma 28.1 PTK2 ITGB1 IGF1 FOS CREB1 CASP9
6 hypoxia 11.4
7 anoxia 11.3
8 ischemia 10.4
9 carotid artery occlusion 10.3
10 encephalopathy 10.2
11 neonatal hypoxic and ischemic brain injury 10.2
12 cardiac arrest 10.1
13 gastric fundus cancer 10.1 ITGB1 ITGAV
14 cerebral artery occlusion 10.1
15 retrograde amnesia 10.1 FOS CREB1
16 ocular motor apraxia 10.1
17 cerebrovascular disease 10.1
18 intracranial hypertension 10.1
19 myoclonus 10.1
20 respiratory failure 10.0
21 cerebral palsy 10.0
22 48,xyyy 10.0
23 opiate dependence 10.0 IGF1 FOS CREB1
24 teeth hard tissue disease 9.9 IGF1 FOS CREB1
25 specific developmental disorder 9.9 IGF1 FOS CREB1
26 status epilepticus 9.9
27 dystonia 9.9
28 cerebral atrophy 9.9
29 seizure disorder 9.9
30 posttransplant acute limbic encephalitis 9.9
31 occlusion precerebral artery 9.9 FOS CASP3
32 morphine dependence 9.9 FOS CREB1
33 cardiomyopathy, familial hypertrophic, 25 9.8 FOS CASP3
34 migraine with or without aura 1 9.8
35 triiodothyronine receptor auxiliary protein 9.8
36 moyamoya disease 1 9.8
37 sudden infant death syndrome 9.8
38 yemenite deaf-blind hypopigmentation syndrome 9.8
39 diabetes mellitus, ketosis-prone 9.8
40 chorea, childhood-onset, with psychomotor retardation 9.8
41 agenesis of corpus callosum, cardiac, ocular, and genital syndrome 9.8
42 metabolic acidosis 9.8
43 focal dystonia 9.8
44 sleep apnea 9.8
45 post-cardiac arrest syndrome 9.8
46 parkinsonism 9.8
47 hydrocephalus 9.8
48 amnestic disorder 9.8
49 intracranial aneurysm 9.8
50 pulmonary edema 9.8

Graphical network of the top 20 diseases related to Cerebral Hypoxia:



Diseases related to Cerebral Hypoxia

Symptoms & Phenotypes for Cerebral Hypoxia

GenomeRNAi Phenotypes related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with paclitaxel GR00179-A-1 8.32 CASP3

MGI Mouse Phenotypes related to Cerebral Hypoxia:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.29 BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
2 cardiovascular system MP:0005385 10.26 BCAR1 CASP3 CASP9 CREB1 FOS IGF1
3 growth/size/body region MP:0005378 10.25 BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
4 endocrine/exocrine gland MP:0005379 10.22 CAMK4 CASP3 CASP9 CREB1 FOS IGF1
5 mortality/aging MP:0010768 10.17 BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
6 hematopoietic system MP:0005397 10.15 CAMK4 CASP3 CASP9 FOS IGF1 ITGAV
7 homeostasis/metabolism MP:0005376 10.13 CAMK4 CASP3 CREB1 FOS IGF1 ITGAV
8 immune system MP:0005387 10.11 CAMK4 CASP3 CASP9 FOS IGF1 ITGAV
9 embryo MP:0005380 10.08 BCAR1 CASP9 CREB1 FOS ITGAV ITGB1
10 nervous system MP:0003631 10.02 CAMK4 CASP3 CASP9 CREB1 FOS IGF1
11 muscle MP:0005369 10.01 BCAR1 CASP3 CREB1 IGF1 ITGAV ITGB1
12 normal MP:0002873 9.8 CAMK4 CREB1 FOS IGF1 ITGB1 NOS1
13 neoplasm MP:0002006 9.77 FOS IGF1 ITGAV ITGB1 PTK2
14 reproductive system MP:0005389 9.76 CAMK4 CASP3 CREB1 FOS IGF1 ITGB1
15 respiratory system MP:0005388 9.5 CASP3 CASP9 CREB1 IGF1 ITGB1 NOS1
16 skeleton MP:0005390 9.17 CAMK4 CASP3 CREB1 FOS IGF1 ITGB1

Drugs & Therapeutics for Cerebral Hypoxia

Drugs for Cerebral Hypoxia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
2 Ether Phase 4
3
Sevoflurane Approved, Vet_approved 28523-86-6 5206
4
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
5
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
6
tannic acid Approved 1401-55-4
7
Glutamic acid Approved, Nutraceutical 56-86-0 33032
8 Hypnotics and Sedatives
9 Anesthetics, Intravenous
10 Platelet Aggregation Inhibitors
11 Anesthetics, General
12 Anesthetics, Inhalation
13 Anesthetics

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Sevoflurane-based Volatile Induction and Maintenance of Anaesthesia (VIMA) Strategy Decreases the Risk of Postoperative Delirium in Elderly Patients With Registered Cerebral Hypoxemia Episodes During General Surgery Unknown status NCT02133638 Phase 4 Sevoflurane;Propofol
2 Anesthesia vs Aviation: Does Added Carbon Dioxide in Normobaric Hypoxia Have the Same Effect on Cerebral Oxygenation as in Hypobaric Hypoxia? Completed NCT03338907 Phase 2 Oxycarbon (5% CO2+ 95% O2)
3 Perioperative Interventions to Optimize Cerebral Oxygen Saturation (rSO2) in High-risk Patients Undergoing Cardiac Surgery Should Have a Beneficial Systemic Effect for Enhancing Global Tissue Perfusion and Improve Outcomes. Completed NCT01432184
4 The Difference in Cerebral Oxygenation Between Propofol and Sevoflurane Completed NCT01757561
5 The Effects of Hypobaria vs Hypoxia on Cerebral Vasoreactivity, Brain's Electrical Activity and Concentration Performance on Pilots. Completed NCT03303118
6 Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia Completed NCT02482571
7 Evaluation of the Cerebral Responses to Exercise in Hypoxia Completed NCT01614119
8 General Movement Assessment - Ancillary Study to SafeBoosC III Trial Recruiting NCT04555915
9 Continuous, Non-invasive Monitoring of Intraoperative Cerebral Perfusion and Oxidative Metabolism (CPOM): a Knowledge Translation Study. Recruiting NCT03907904
10 COOLPRIME: Comparative Effectiveness for Cooling Prospectively Infants With Mild Encephalopathy Not yet recruiting NCT04621279
11 Monitoring Of REgional Cerebral Oxygenation (rcSO2 ) With Near INFrared SpectrOscopy (NIRS) During Non-cardiac Surgery in Preterms, Neonates and Infants in Addition to Standard Monitoring to Guide Intraoperative Management Not yet recruiting NCT04132414
12 Targeted Cerebral Saturations in Extremely Preterm Infants Not yet recruiting NCT04439968

Search NIH Clinical Center for Cerebral Hypoxia

Genetic Tests for Cerebral Hypoxia

Anatomical Context for Cerebral Hypoxia

MalaCards organs/tissues related to Cerebral Hypoxia:

40
Brain, Cortex, Endothelial, Cerebellum, Skin, Fetal Brain, Hypothalamus

Publications for Cerebral Hypoxia

Articles related to Cerebral Hypoxia:

(show top 50) (show all 1737)
# Title Authors PMID Year
1
Effect of hypoxia on the expression of procaspase-9 and procaspase-3 in neuronal nuclear, mitochondrial and cytosolic fractions of the cerebral cortex of newborn piglets. 61 54
18468794 2008
2
ATP and cytochrome c-dependent activation of caspase-9 during hypoxia in the cerebral cortex of newborn piglets. 54 61
17976908 2007
3
Differential expression of apoptotic proteins following hypoxia-induced CREB phosphorylation in the cerebral cortex of newborn piglets. 54 61
17401658 2007
4
Mechanism of activation of caspase-9 and caspase-3 during hypoxia in the cerebral cortex of newborn piglets: the role of nuclear Ca2+ -influx. 61 54
17268855 2007
5
Hypoxia-induced Bax and Bcl-2 protein expression, caspase-9 activation, DNA fragmentation, and lipid peroxidation in mitochondria of the cerebral cortex of newborn piglets: the role of nitric oxide. 54 61
16777344 2006
6
Effect of 7-nitroindazole sodium on the cellular distribution of neuronal nitric oxide synthase in the cerebral cortex of hypoxic newborn piglets. 54 61
16804757 2006
7
Effect of neuronal nitric oxide synthase inhibition on caspase-9 activity during hypoxia in the cerebral cortex of newborn piglets. 61 54
16545906 2006
8
Anaemia and the brain. 54 61
17023891 2004
9
Effect of hypoxia on protein phosphatase 2A activity, subcellular distribution and expression in cerebral cortex of newborn piglets. 61 54
15262326 2004
10
Up-regulating lncRNA OIP5-AS1 protects neuron injury against cerebral hypoxia-ischemia induced inflammation and oxidative stress in microglia/macrophage through activating CTRP3 via sponging miR-186-5p. 61
33516048 2021
11
Crocin mitigated cognitive impairment and brain molecular alterations induced by different intensities of prenatal hypoxia in neonatal rats. 61
33586916 2021
12
Multimodal monitoring to aid detection and management of intraoperative seizures: a case report. 61
31960222 2021
13
Association between early cerebral oxygenation and neurodevelopmental impairment or death in premature infants. 61
33589727 2021
14
Neonatal NIRS monitoring: recommendations for data capture and review of analytics. 61
33589724 2021
15
Mitigation of acute radiation-induced brain injury in a mouse model using anlotinib. 61
33545766 2021
16
A Rationale for Hypoxic and Chemical Conditioning in Huntington's Disease. 61
33430140 2021
17
Alpha coma EEG pattern in patients with severe COVID-19 related encephalopathy. 61
33060058 2021
18
Relationship of common hemodynamic and respiratory target parameters with brain tissue oxygen tension in the absence of hypoxemia or hypotension after cardiac arrest: A post-hoc analysis of an experimental study using a pig model. 61
33539360 2021
19
Selective Neuronal Mitochondrial Targeting in SARS-CoV-2 Infection Affects Cognitive Processes to Induce 'Brain Fog' and Results in Behavioral Changes that Favor Viral Survival. 61
33487628 2021
20
The Relationship Between Brain Tissue Oxygen Tension (PbtO2) and Transcranial Doppler Ultrasonography. 61
33513443 2021
21
Hypoxia-Induced S100A8 Expression Activates Microglial Inflammation and Promotes Neuronal Apoptosis. 61
33530496 2021
22
Inactivation of HIF-prolyl 4-hydroxylases 1, 2 and 3 in NG2-expressing cells induces HIF2-mediated neurovascular expansion independent of erythropoietin. 61
32846048 2021
23
Ten physiological commandments for severe head injury. 61
33487456 2021
24
Serum-neuroproteins, near-infrared spectroscopy, and cognitive outcome after beach-chair shoulder surgery: Observational cohort study analyses. 61
32812646 2021
25
Monocytic Infiltrates Contribute to Autistic-like Behaviors in a Two-Hit Model of Neurodevelopmental Defects. 61
33127853 2020
26
A physiologically validated rat model of term birth asphyxia with seizure generation after, not during, brain hypoxia. 61
33338272 2020
27
In a Rat Model of Opioid Maintenance, the G Protein-Biased Mu Opioid Receptor Agonist TRV130 Decreases Relapse to Oxycodone Seeking and Taking and Prevents Oxycodone-Induced Brain Hypoxia. 61
32305216 2020
28
Hypoxia, Oxidative Stress, and Inflammation: Three Faces of Neurodegenerative Diseases. 61
33325385 2020
29
Hanging disguised as bondage: accidental or suicidal death? 61
32495262 2020
30
Human umbilical cord mesenchymal stromal cells as an adjunct therapy with therapeutic hypothermia in a piglet model of perinatal asphyxia. 61
33262073 2020
31
Incidence and characteristics of cerebral hypoxia after craniectomy in brain-injured patients: a cohort study. 61
33157533 2020
32
Amyloid-beta peptide and phosphorylated tau in the frontopolar cerebral cortex and in the cerebellum of toothed whales: aging versus hypoxia. 61
33037014 2020
33
Efficacy of Citicoline as a Neuroprotector in children with post cardiac arrest: a randomized controlled clinical trial. 61
33169240 2020
34
Cocaine added to heroin fails to affect heroin-induced brain hypoxia. 61
32645379 2020
35
Unannotated single nucleotide polymorphisms in the TATA box of erythropoiesis genes show in vitro positive involvements in cognitive and mental disorders. 61
33092544 2020
36
Continuous Near-infrared Spectroscopy Monitoring in Adult Traumatic Brain Injury: A Systematic Review. 61
31306264 2020
37
Influenza A virus causes maternal and fetal pathology via innate and adaptive vascular inflammation in mice. 61
32958663 2020
38
The hidden consequence of intraventricular hemorrhage: persistent cerebral desaturation after IVH in preterm infants. 61
33038871 2020
39
TRPM4 inhibition improves spatial memory impairment and hippocampal long-term potentiation deficit in chronic cerebral hypoperfused rats. 61
32619565 2020
40
Storms and silence: a case report of catatonia and paroxysmal sympathetic hyperactivity following cerebral hypoxia. 61
32993556 2020
41
Cognitive impairment and psychopathology in out-of-hospital cardiac arrest survivors in Denmark: The REVIVAL cohort study protocol. 61
32994252 2020
42
Cardiovascular and cerebrovascular responses to cardio-respiratory events in preterm infants during the transitional period. 61
32592405 2020
43
Offspring of rats with cerebral hypoxia-ischemia manifest cognitive dysfunction in learning and memory abilities. 61
32209770 2020
44
Does intentional asphyxiation by strangulation have addictive properties? 61
32888239 2020
45
Landmark clinical observations and immunopathogenesis pathways linked to HIV and Cryptococcus fatal central nervous system co-infection. 61
32472727 2020
46
Accelerated loss of hypoxia response in zebrafish with familial Alzheimer's disease-like mutation of presenilin 1. 61
32588886 2020
47
Social cognition in an adult epilepsy patient with developmental amnesia. 61
32657245 2020
48
MiR-17-5p inhibits cerebral hypoxia/reoxygenationinjury by targeting PTEN through regulation of PI3K/AKT/mTOR signaling pathway. 61
32762281 2020
49
Yap-Hippo pathway regulates cerebral hypoxia-reoxygenation injury in neuroblastoma N2a cells via inhibiting ROCK1/F-actin/mitochondrial fission pathways. 61
29796942 2020
50
MicroRNA-195 prevents hippocampal microglial/macrophage polarization towards the M1 phenotype induced by chronic brain hypoperfusion through regulating CX3CL1/CX3CR1 signaling. 61
32819407 2020

Variations for Cerebral Hypoxia

Expression for Cerebral Hypoxia

Search GEO for disease gene expression data for Cerebral Hypoxia.

Pathways for Cerebral Hypoxia

Pathways related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.08 PTK2 ITGB1 ITGAV IGF1 CREB1 CASP9
2
Show member pathways
13.94 PTK2 NOS1 ITGB1 ITGAV FOS CREB1
3
Show member pathways
13.77 PTK2 ITGB1 ITGAV IGF1 FOS CREB1
4
Show member pathways
13.72 PTK2 ITGB1 ITGAV IGF1 FOS CREB1
5
Show member pathways
13.62 PTK2 ITGB1 ITGAV IGF1 FOS CREB1
6
Show member pathways
13.36 PTK2 ITGB1 ITGAV FOS CREB1 CASP3
7
Show member pathways
13.32 PTK2 ITGB1 ITGAV IGF1 FOS CREB1
8
Show member pathways
13.27 PTK2 NOS1 ITGB1 ITGAV IGF1 BCAR1
9
Show member pathways
13.24 PTK2 IGF1 FOS CASP9 CASP3
10
Show member pathways
13 PTK2 ITGB1 ITGAV IGF1 CREB1 CAMK4
11
Show member pathways
12.96 PTK2 IGF1 FOS CASP3 CAMK4 BCAR1
12
Show member pathways
12.91 PTK2 ITGB1 IGF1 FOS CASP9 CASP3
13
Show member pathways
12.9 PTK2 ITGB1 ITGAV IGF1 CREB1 CASP9
14
Show member pathways
12.89 PTK2 NOS1 ITGB1 ITGAV FOS BCAR1
15
Show member pathways
12.88 PTK2 ITGB1 IGF1 FOS BCAR1
16
Show member pathways
12.86 PTK2 ITGB1 ITGAV IGF1 FOS BCAR1
17
Show member pathways
12.84 PTK2 ITGAV FOS CREB1 CASP9 CASP3
18
Show member pathways
12.77 PTK2 ITGB1 ITGAV FOS CREB1 CAMK4
19
Show member pathways
12.76 PTK2 ITGB1 ITGAV IGF1 CREB1 CASP9
20
Show member pathways
12.73 NOS1 FOS CREB1 CAMK4
21 12.73 PTK2 ITGB1 ITGAV IGF1 FOS CASP9
22 12.72 IGF1 FOS CASP9 CASP3
23
Show member pathways
12.7 ITGB1 FOS CASP9 CASP3
24
Show member pathways
12.67 IGF1 FOS CASP9 CASP3
25
Show member pathways
12.67 PTK2 IGF1 FOS CASP9 CAMK4
26
Show member pathways
12.62 PTK2 NOS1 IGF1 FOS CREB1 BCAR1
27 12.6 PTK2 ITGB1 ITGAV BCAR1
28
Show member pathways
12.57 PTK2 NOS1 ITGB1 FOS CASP9
29
Show member pathways
12.56 FOS CASP9 CASP3 BCAR1
30
Show member pathways
12.55 PTK2 IGF1 CASP9 BCAR1
31
Show member pathways
12.51 NOS1 FOS CREB1 CAMK4
32
Show member pathways
12.5 PTK2 ITGB1 IGF1 FOS CREB1 CASP9
33
Show member pathways
12.47 PTK2 ITGB1 FOS CREB1 CASP3
34
Show member pathways
12.43 PTK2 ITGB1 ITGAV CASP9 CASP3
35
Show member pathways
12.39 IGF1 FOS CREB1 CASP9
36
Show member pathways
12.39 PTK2 ITGAV FOS CREB1 CASP9
37
Show member pathways
12.38 IGF1 CREB1 CASP9 CASP3
38
Show member pathways
12.38 ITGB1 ITGAV IGF1 FOS BCAR1
39 12.3 PTK2 ITGB1 ITGAV IGF1 CASP3
40 12.29 FOS CREB1 CAMK4
41
Show member pathways
12.29 PTK2 ITGB1 FOS CREB1 CASP3
42
Show member pathways
12.28 IGF1 CREB1 CAMK4
43
Show member pathways
12.27 PTK2 NOS1 ITGAV FOS CASP9 CASP3
44
Show member pathways
12.26 ITGB1 FOS CASP9 CASP3
45
Show member pathways
12.24 PTK2 ITGB1 ITGAV FOS CREB1 CASP9
46
Show member pathways
12.22 FOS CASP9 CASP3
47
Show member pathways
12.22 ITGB1 ITGAV IGF1
48 12.2 CREB1 CASP9 CASP3
49 12.2 PTK2 ITGB1 ITGAV
50 12.19 PTK2 FOS CREB1 BCAR1

GO Terms for Cerebral Hypoxia

Cellular components related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.55 PTK2 NOS1 ITGB1 ITGAV BCAR1
2 integrin complex GO:0008305 9.26 ITGB1 ITGAV
3 focal adhesion GO:0005925 9.26 PTK2 ITGB1 ITGAV BCAR1
4 alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867 8.62 ITGAV IGF1

Biological processes related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.88 NOS1 IGF1 FOS CREB1 CAMK4
2 positive regulation of apoptotic process GO:0043065 9.8 ITGB1 CREB1 CASP9 CASP3
3 aging GO:0007568 9.79 FOS CREB1 CASP9
4 response to hypoxia GO:0001666 9.77 NOS1 CREB1 CASP3
5 response to organic cyclic compound GO:0014070 9.71 FOS CASP9 CASP3
6 ERK1 and ERK2 cascade GO:0070371 9.63 ITGAV IGF1
7 response to antibiotic GO:0046677 9.63 CASP9 CASP3
8 heterotypic cell-cell adhesion GO:0034113 9.62 ITGB1 ITGAV
9 response to lipopolysaccharide GO:0032496 9.62 NOS1 FOS CASP9 CASP3
10 execution phase of apoptosis GO:0097194 9.61 CASP9 CASP3
11 positive regulation of wound healing GO:0090303 9.61 PTK2 ITGB1
12 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.61 PTK2 ITGAV BCAR1
13 positive regulation of osteoclast differentiation GO:0045672 9.59 FOS CREB1
14 cell adhesion mediated by integrin GO:0033627 9.58 ITGB1 ITGAV
15 neurotrophin TRK receptor signaling pathway GO:0048011 9.58 CASP3 BCAR1
16 cell-substrate adhesion GO:0031589 9.57 ITGB1 ITGAV
17 negative regulation of anoikis GO:2000811 9.56 PTK2 ITGB1
18 platelet formation GO:0030220 9.55 CASP9 CASP3
19 cellular response to hepatocyte growth factor stimulus GO:0035729 9.52 CREB1 BCAR1
20 positive regulation of fibroblast migration GO:0010763 9.51 PTK2 ITGB1
21 response to cobalt ion GO:0032025 9.46 CASP9 CASP3
22 transforming growth factor beta receptor signaling pathway GO:0007179 9.46 PTK2 ITGB1 FOS CREB1
23 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.43 ITGAV CASP9 CASP3
24 leukocyte apoptotic process GO:0071887 9.4 CASP9 CASP3
25 glial cell apoptotic process GO:0034349 9.37 CASP9 CASP3
26 integrin-mediated signaling pathway GO:0007229 9.26 PTK2 ITGB1 ITGAV BCAR1
27 positive regulation of cell migration GO:0030335 9.02 PTK2 ITGB1 ITGAV IGF1 BCAR1

Molecular functions related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.43 ITGB1 ITGAV CASP3
2 fibronectin binding GO:0001968 9.4 ITGB1 ITGAV
3 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.37 CASP9 CASP3
4 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 9.32 CASP9 CASP3
5 cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097199 9.16 CASP9 CASP3
6 C-X3-C chemokine binding GO:0019960 8.96 ITGB1 ITGAV
7 integrin binding GO:0005178 8.92 PTK2 ITGB1 ITGAV IGF1

Sources for Cerebral Hypoxia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....