MCID: CRB090
MIFTS: 43

Cerebral Hypoxia

Categories: Neuronal diseases

Aliases & Classifications for Cerebral Hypoxia

MalaCards integrated aliases for Cerebral Hypoxia:

Name: Cerebral Hypoxia 53 54
Brain Hypoxia 71

Classifications:



External Ids:

UMLS 71 C1527348

Summaries for Cerebral Hypoxia

NINDS : 53 Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.  In brain death, there is no measurable activity in the brain, although cardiovascular function is preserved. Life support is required for respiration.

MalaCards based summary : Cerebral Hypoxia, also known as brain hypoxia, is related to brain injury and traumatic brain injury. An important gene associated with Cerebral Hypoxia is CAMK4 (Calcium/Calmodulin Dependent Protein Kinase IV), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Sevoflurane and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

Wikipedia : 74 Cerebral hypoxia is a form of hypoxia (reduced supply of oxygen), specifically involving the brain; when... more...

Related Diseases for Cerebral Hypoxia

Diseases related to Cerebral Hypoxia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 brain injury 30.0 IGF1 CASP3
2 traumatic brain injury 29.9 IGF1 CASP3
3 ocular dominance 29.3 NOS1 CREB1
4 neuroblastoma 27.2 PTK2 ITGB1 IGF1 FOS CREB1 CASP9
5 anoxia 11.8
6 hypoxia 10.9
7 ischemia 10.6
8 carotid artery occlusion 10.3
9 cardiac arrest 10.2
10 neonatal hypoxic and ischemic brain injury 10.1
11 encephalopathy 10.1
12 retrograde amnesia 10.0 FOS CREB1
13 ocular motor apraxia 10.0
14 cerebral artery occlusion 10.0
15 respiratory failure 10.0
16 cerebrovascular disease 10.0
17 intracranial hypertension 10.0
18 myoclonus 10.0
19 cerebral palsy 9.9
20 opiate dependence 9.9 IGF1 FOS CREB1
21 amelogenesis imperfecta, type ig 9.9 IGF1 FOS CREB1
22 teeth hard tissue disease 9.9 IGF1 FOS CREB1
23 stroke, ischemic 9.8
24 hydrops, lactic acidosis, and sideroblastic anemia 9.8
25 visual epilepsy 9.8
26 status epilepticus 9.8
27 dystonia 9.8
28 seizure disorder 9.8
29 posttransplant acute limbic encephalitis 9.8
30 morphine dependence 9.8 FOS CREB1
31 atherosclerosis susceptibility 9.7
32 migraine with or without aura 1 9.7
33 triiodothyronine receptor auxiliary protein 9.7
34 moyamoya disease 1 9.7
35 sudden infant death syndrome 9.7
36 body mass index quantitative trait locus 11 9.7
37 yemenite deaf-blind hypopigmentation syndrome 9.7
38 body mass index quantitative trait locus 9 9.7
39 body mass index quantitative trait locus 8 9.7
40 body mass index quantitative trait locus 4 9.7
41 body mass index quantitative trait locus 10 9.7
42 body mass index quantitative trait locus 7 9.7
43 diabetes mellitus, ketosis-prone 9.7
44 body mass index quantitative trait locus 12 9.7
45 body mass index quantitative trait locus 14 9.7
46 body mass index quantitative trait locus 18 9.7
47 chorea, childhood-onset, with psychomotor retardation 9.7
48 body mass index quantitative trait locus 19 9.7
49 body mass index quantitative trait locus 20 9.7
50 pulmonary hypertension 9.7

Graphical network of the top 20 diseases related to Cerebral Hypoxia:



Diseases related to Cerebral Hypoxia

Symptoms & Phenotypes for Cerebral Hypoxia

GenomeRNAi Phenotypes related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.92 CASP3 IGF1 PTK2
2 Decreased viability with paclitaxel GR00179-A-2 8.92 IGF1

MGI Mouse Phenotypes related to Cerebral Hypoxia:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.29 BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
2 growth/size/body region MP:0005378 10.25 BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
3 endocrine/exocrine gland MP:0005379 10.22 CAMK4 CASP3 CASP9 CREB1 FOS IGF1
4 cardiovascular system MP:0005385 10.21 BCAR1 CASP3 CASP9 CREB1 IGF1 ITGAV
5 mortality/aging MP:0010768 10.17 BCAR1 CAMK4 CASP3 CASP9 CREB1 FOS
6 hematopoietic system MP:0005397 10.15 CAMK4 CASP3 CASP9 FOS IGF1 ITGAV
7 homeostasis/metabolism MP:0005376 10.13 CAMK4 CASP3 CREB1 FOS IGF1 ITGAV
8 immune system MP:0005387 10.11 CAMK4 CASP3 CASP9 FOS IGF1 ITGAV
9 embryo MP:0005380 10.08 BCAR1 CASP9 CREB1 FOS ITGAV ITGB1
10 nervous system MP:0003631 10.02 CAMK4 CASP3 CASP9 CREB1 FOS IGF1
11 muscle MP:0005369 10.01 BCAR1 CASP3 CREB1 IGF1 ITGAV ITGB1
12 normal MP:0002873 9.8 CAMK4 CREB1 FOS IGF1 ITGB1 NOS1
13 neoplasm MP:0002006 9.77 FOS IGF1 ITGAV ITGB1 PTK2
14 reproductive system MP:0005389 9.76 CAMK4 CASP3 CREB1 FOS IGF1 ITGB1
15 respiratory system MP:0005388 9.5 CASP3 CASP9 CREB1 IGF1 ITGB1 NOS1
16 skeleton MP:0005390 9.17 CAMK4 CASP3 CREB1 FOS IGF1 ITGB1

Drugs & Therapeutics for Cerebral Hypoxia

Drugs for Cerebral Hypoxia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
3
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
4
Racepinephrine Approved Phase 4 329-65-7 838
5 Ether Phase 4
6 Epinephryl borate Phase 4
7
Allopurinol Approved Phase 3 315-30-0 2094
8
Mannitol Approved, Investigational Phase 3 69-65-8 453 6251
9
Creatine Approved, Investigational, Nutraceutical Phase 3 57-00-1 586
10 Antioxidants Phase 3
11 Protective Agents Phase 3
12 Antirheumatic Agents Phase 3
13 Natriuretic Agents Phase 3
14 Free Radical Scavengers Phase 3
15 Antimetabolites Phase 3
16 diuretics Phase 3
17
Clonidine Approved Phase 1, Phase 2 4205-90-7 2803
18 Xenon Experimental Phase 2 7440-63-3
19 Anesthetics Phase 2
20 Anesthetics, General Phase 2
21 Anesthetics, Inhalation Phase 2
22 Central Nervous System Depressants Phase 2
23 Neurotransmitter Agents Phase 1, Phase 2
24 Antihypertensive Agents Phase 1, Phase 2
25 Analgesics Phase 1, Phase 2
26 Adrenergic Agonists Phase 1, Phase 2
27 Adrenergic alpha-2 Receptor Agonists Phase 1, Phase 2
28 Autonomic Agents Phase 1, Phase 2
29 Sympatholytics Phase 1, Phase 2
30 Adrenergic Agents Phase 1, Phase 2
31
tannic acid Approved 1401-55-4
32
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
33
Remifentanil Approved 132875-61-7 60815
34
Nitroglycerin Approved, Investigational 55-63-0 4510
35
Glycerol Approved, Investigational 56-81-5 753
36
Resveratrol Approved, Experimental, Investigational 501-36-0 445154
37
Desflurane Approved 57041-67-5 42113
38
Temozolomide Approved, Investigational 85622-93-1 5394
39
Dexmedetomidine Approved, Vet_approved 113775-47-6 68602 5311068
40
Dobutamine Approved 34368-04-2 36811
41
Dopamine Approved 51-61-6, 62-31-7 681
42
Alprostadil Approved, Investigational 745-65-3 149351 5280723
43
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
44
Glutamic acid Approved, Nutraceutical 56-86-0 33032
45
Vitamin A Approved, Nutraceutical, Vet_approved 68-26-8, 11103-57-4, 22737-96-8 445354 9904001
46
Cysteine Approved, Nutraceutical 52-90-4 5862
47 Platelet Aggregation Inhibitors
48 Pharmaceutical Solutions
49 Anti-Inflammatory Agents
50 Analgesics, Non-Narcotic

Interventional clinical trials:

(show top 50) (show all 64)
# Name Status NCT ID Phase Drugs
1 Sevoflurane-based Volatile Induction and Maintenance of Anaesthesia (VIMA) Strategy Decreases the Risk of Postoperative Delirium in Elderly Patients With Registered Cerebral Hypoxemia Episodes During General Surgery Unknown status NCT02133638 Phase 4 Sevoflurane;Propofol
2 Does the Early Use of Sodium Bicarbonate Improve Results of Cardiopulmonary Resuscitation Following Out-of-Hospital Cardiac Arrest - a Prospective, Controlled Clinical Trial Unknown status NCT01377337 Phase 4 sodium bicarbonate
3 Hyperoxia: An Unrecognized Mechanism for Inducing "Hypoxia-Like" Symptoms Completed NCT03268590 Phase 4 Oxygen
4 Multicenter Double-blind Placebo-controlled Parallel-group Randomized Clinical Trial of Efficacy and Safety of Tenoten for Children Liquid Dosage Form Therapy in Infants With Sequelae of Perinatal Brain Injury Completed NCT03159611 Phase 3 Tenoten for children;Placebo
5 Randomized Controlled Trial of Hypothermia for Hypoxic-Ischemic Encephalopathy in Term Infants Completed NCT00005772 Phase 3
6 Evaluation of Systemic Hypothermia Initiated After 6 Hours of Age in Infants ≥36 Weeks Gestation With Hypoxic-Ischemic Encephalopathy: A Bayesian Evaluation. A Protocol for the NICHD Neonatal Research Network Completed NCT00614744 Phase 2, Phase 3
7 Creatine as a New Treatment for Schizophrenia:A Double-Blind Trial Completed NCT00140192 Phase 3 creatine
8 Effect of ALlopurinol in Addition to Hypothermia for Hypoxic-ischemic Brain Injury on Neurocognitive Outcome - a Blinded Randomized Placebo-controlled Parallel Group Multicenter Trial for Superiority (Phase III) Recruiting NCT03162653 Phase 3 Allopurinol;Mannitol
9 A Randomized Trial of Targeted Temperature Management With Whole Body Hypothermia For Moderate And Severe Hypoxic-Ischemic Encephalopathy In Premature Infants 33-35 Weeks Gestational Age. Recruiting NCT01793129 Phase 2, Phase 3
10 Transfusion Strategies in Acute Brain Injured Patients. A Prospective Multicenter Randomized Study. Recruiting NCT02968654 Phase 3
11 Optimizing Cooling Strategies at < 6 Hours of Age for Neonatal Hypoxic-Ischemic Encephalopathy Terminated NCT01192776 Phase 3
12 Neuroplasticity of Brain-Asphyxiated Infants: Efficacy of Intervention Completed NCT00006516 Phase 2
13 Anesthesia vs Aviation: Does Added Carbon Dioxide in Normobaric Hypoxia Have the Same Effect on Cerebral Oxygenation as in Hypobaric Hypoxia? Completed NCT03338907 Phase 2 Oxycarbon (5% CO2+ 95% O2)
14 Phase 2 Study of Effect of Xenon, in Combination With Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest Patients Completed NCT00879892 Phase 2 xenon
15 Phase I-II Clinical Trial to Determine the Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia Completed NCT01862250 Phase 1, Phase 2 Clonidine (Duraclon®)
16 A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy for the Treatment of Traumatic Brain Injury and Hypoxic-Ischemic Encephalopathy Not yet recruiting NCT04063215 Phase 1, Phase 2 HB-adMSC
17 Role of Cerebral Blood Flow on Ventilatory Stability During Sleep in Normoxia and Intermittent Hypoxia Not yet recruiting NCT03255408 Phase 1, Phase 2 Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep;Drug Lowering CBF and Intermittent Hypoxia Sleep;Placebo and Normoxia Sleep;Placebo and Intermittent Hypoxia Sleep
18 The Difference in Cerebral Oxygenation Between Propofol and Sevoflurane Completed NCT01757561
19 Perioperative Interventions to Optimize Cerebral Oxygen Saturation (rSO2) in High-risk Patients Undergoing Cardiac Surgery Should Have a Beneficial Systemic Effect for Enhancing Global Tissue Perfusion and Improve Outcomes. Completed NCT01432184
20 The Effects of Hypobaria vs Hypoxia on Cerebral Vasoreactivity, Brain's Electrical Activity and Concentration Performance on Pilots. Completed NCT03303118
21 Assessment of Tele-expertise for the Interpretation of MRI Among Neonates With High Risk of Neurological Sequelae Completed NCT03706651
22 Pilot Trial Concerning Glutamate Elimination With CRRT for Neurological Outcome After Cardiac Arrest Completed NCT02963298
23 Septic Shock and Delirium Because of rSO2 Abnormalities in Intensive Care Unit Patients (The SAD BRAIN Study) Completed NCT01836302
24 Near Infrared Spectroscopy in Aortic Valve Replacement Completed NCT01251328
25 The Impact of a Beach Chair Position During Shoulder Arthroscopy on Regional Cerebral Oxygen Saturation : Comparison of Interscalene Block and General Anesthesia Completed NCT02605005
26 Metabolic Changes in the Activated Human Visual Cortex During Mild Hypoxia Completed NCT02482571
27 Oxygenation of the Neonatal Brain - a Study Using the INVOS Oximeter Completed NCT01684618
28 Oxygenation of the Neonatal Brain - a Study Using the INVOS Oximeter Completed NCT01690650 Oxygen
29 Effects of High Inspiratory Oxygen on Cerebral Tissue Oxygenation and Patient Recovery After Carotid Endarterectomy Completed NCT02991976
30 Postoperative Delirium in Patients Undergoing Hip Arthroplasty Completed NCT02323984
31 Effect of Hypotensive Anesthesia on Cerebral Perfusion and Blood Antioxidant Levels and HIF 1a Completed NCT04174417
32 A Multicentre Prospective Study on Magnetic Resonance Biomarkers in Neonatal Encephalopathy Completed NCT01309711
33 The Effects of Acute Trans-resveratrol Supplementation on Aspects of Cognitive Function and Cerebral Blood Flow, During Hypoxia and Normoxia, in Healthy, Young Humans. Completed NCT03100019 Placebo
34 Comparison of Low Versus Normal Flow Anesthesia on Cerebral Oxygenation and Bispectral Index in Morbidly Obese Patients Undergoing Sleeve Gastrectomy: Prospective, Randomized Clinical Trial Completed NCT03438734
35 Retrospective Evaluation of Prognostic and/or Predictive Profile of Melanocortin Receptor-4 Gene Polymorphisms in Patient With a Diagnosis of Glioblastoma Treated With Upfront Concomitant Radio-chemotherapy or Chemotherapy Completed NCT02458508
36 Evaluation of the Cerebral Responses to Exercise in Hypoxia Completed NCT01614119
37 Brain-computer Interface in the Diagnosis of Disorders of Consciousness Completed NCT03998930
38 Optimizing Cerebral Oxygenation in Cardiac Surgery Completed NCT01539382
39 Hypoxia and Outcome Prediction in Early Stage Coma: Towards an Improvement of Clinical and Electrophysiological Predictors Completed NCT02231060
40 EARLY TRACHEOSTOMY VERSUS STANDARD OF CARE, A RANDOMIZED CONTROLLED CLINICAL TRIAL IN PATIENTS WITH SEVERE HEAD INJURY IN MULAGO HOSPITAL Completed NCT02442154
41 BiHiVE 2 Study. The Investigation and Validation of Predictive Biomarkers in Hypoxic-ischaemic Encephalopathy. Completed NCT02019147
42 Cardio-respiratory Events in VLBW Preterm Infants During the Transitional Period: Clinical Features and Impact of Neonatal Characteristics. Completed NCT04123691
43 Validation of the Predictive Value of the FORE-SIGHT™ Monitor for Early Detection of Hemodynamic Deterioration After Pediatric Cardiac Surgery. A Data-mining Study. Completed NCT01706497
44 NeoAdapt 3: An Observational Study Investigating Novel Biomarkers in the Evaluation and Treatment of Neonatal Circulatory Insufficiency in Infants Suffering From Hypoxic Ischemic Encephalopathy. Completed NCT02051894 Dobutamine
45 Impact of Early Optimization of Brain Oxygenation on Neurological Outcome After Severe Traumatic Brain Injury Recruiting NCT02754063
46 Correlating Brain Tissue Oxygen Tension (PbrO2) and Regional Cerebral Oximetry (rSO2) in Normal Human Brain Under the Conditions of Changing Ventilation Strategy Recruiting NCT03128957
47 TAME Cardiac Arrest Trial: Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest: A Phase III Multi-Centre Randomised Controlled Trial Recruiting NCT03114033
48 Cerebral Regional Tissue Oxygen Saturation to Guide Oxygen Delivery in Preterm Neonates During Immediate Transition After Birth: An Investigator-initiated Randomised Multi-centre Multinational Clinical Trial Recruiting NCT03166722
49 Predicting Neurological Outcome Following Out of Hospital Cardiac Arrest (OHCA) by Quantitative Measurement of Serial Serum Biomarkers of Brain Injury. Recruiting NCT03112486
50 Neuroprotective Role of Lactate Therapy in Humans With Traumatic Brain Injury Recruiting NCT01573507

Search NIH Clinical Center for Cerebral Hypoxia

Genetic Tests for Cerebral Hypoxia

Anatomical Context for Cerebral Hypoxia

MalaCards organs/tissues related to Cerebral Hypoxia:

40
Brain, Cortex, Heart, Endothelial, Liver, Kidney, Testes

Publications for Cerebral Hypoxia

Articles related to Cerebral Hypoxia:

(show top 50) (show all 1677)
# Title Authors PMID Year
1
Effect of hypoxia on the expression of procaspase-9 and procaspase-3 in neuronal nuclear, mitochondrial and cytosolic fractions of the cerebral cortex of newborn piglets. 54 61
18468794 2008
2
ATP and cytochrome c-dependent activation of caspase-9 during hypoxia in the cerebral cortex of newborn piglets. 54 61
17976908 2007
3
Differential expression of apoptotic proteins following hypoxia-induced CREB phosphorylation in the cerebral cortex of newborn piglets. 54 61
17401658 2007
4
Mechanism of activation of caspase-9 and caspase-3 during hypoxia in the cerebral cortex of newborn piglets: the role of nuclear Ca2+ -influx. 54 61
17268855 2007
5
Hypoxia-induced Bax and Bcl-2 protein expression, caspase-9 activation, DNA fragmentation, and lipid peroxidation in mitochondria of the cerebral cortex of newborn piglets: the role of nitric oxide. 54 61
16777344 2006
6
Effect of 7-nitroindazole sodium on the cellular distribution of neuronal nitric oxide synthase in the cerebral cortex of hypoxic newborn piglets. 54 61
16804757 2006
7
Effect of neuronal nitric oxide synthase inhibition on caspase-9 activity during hypoxia in the cerebral cortex of newborn piglets. 54 61
16545906 2006
8
Anaemia and the brain. 54 61
17023891 2004
9
Effect of hypoxia on protein phosphatase 2A activity, subcellular distribution and expression in cerebral cortex of newborn piglets. 54 61
15262326 2004
10
Wheel running for 26 weeks is associated with sustained vascular plasticity in the rat motor cortex. 61
31870777 2020
11
Protective effect of Hydralazine on a cellular model of Parkinson's disease: a possible role of hypoxia-inducible factor (HIF)-1α. 61
31940231 2020
12
NIRS in the fetal to neonatal transition and immediate postnatal period. 61
32007425 2020
13
Aqueous extract of Dendrobium officinale confers neuroprotection against hypoxic-ischemic brain damage in neonatal rats. 61
31642199 2020
14
The Role of Peripheral Opioid Receptors in Triggering Heroin-induced Brain Hypoxia. 61
31964994 2020
15
Defining a Time Window for Neuroprotection and Glia Modulation by Caffeine After Neonatal Hypoxia-Ischaemia. 61
31974940 2020
16
Endothelial Autophagy: an Effective Target for Radiation-induced Cerebral Capillary Damage. 61
31953486 2020
17
Neonatal cerebral hypoxia-ischemia in mice triggers age-dependent vascular effects and disabilities in adults; implication of tissue plasminogen activator (tPA). 61
31697944 2020
18
A management algorithm for adult patients with both brain oxygen and intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC). 61
31965267 2020
19
Cerebral blood flow dynamic in foetuses with hypoplastic left heart syndrome: Incremental value of the first segment of the anterior cerebral artery over the middle cerebral artery? 61
31525274 2020
20
Neuroprotective effects of resveratrol against oxygen glucose deprivation induced mitochondrial dysfunction by activation of AMPK in SH-SY5Y cells with 3D gelatin scaffold. 61
31586626 2020
21
Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemia. 61
31941841 2020
22
Comprehensive Functional Echocardiographic Assessment of Transposition of the Great Arteries: From Fetus to Newborn. 61
31919591 2020
23
Multimodal monitoring to aid detection and management of intraoperative seizures: a case report. 61
31960222 2020
24
Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy. 61
31622925 2020
25
Cerebral near-infrared spectroscopy monitoring versus treatment as usual for extremely preterm infants: a protocol for the SafeBoosC randomised clinical phase III trial. 61
31888764 2019
26
Pharmacological HIF1 Inhibition Eliminates Downregulation of the Pentose Phosphate Pathway and Prevents Neuronal Apoptosis in Rat Hippocampus Caused by Severe Hypoxia. 61
31865524 2019
27
Oxygen-Glucose Deprivation/Reoxygenation-Induced Barrier Disruption at the Human Blood-Brain Barrier is Partially Mediated Through the HIF-1 Pathway. 61
30911877 2019
28
A mathematical model of cerebral blood flow control in anaemia and hypoxia. 61
31823369 2019
29
Phytoestrogen coumestrol attenuates brain mitochondrial dysfunction and long-term cognitive deficits following neonatal hypoxia-ischemia. 61
31693927 2019
30
Long noncoding RNA-regulator of reprogramming alleviates hypoxia-induced cerebral injury in mice model and human via modulating apoptosis complexes. 61
31912702 2019
31
Protective effects of polygalasaponin F on oxidative stress and apoptosis-induced ischemic myocardial injury in neonatal rats with hypoxic-ischemic brain damage. 61
31609825 2019
32
Metoprolol prevents neuronal dendrite remodeling in a canine model of chronic obstructive sleep apnea. 61
31863057 2019
33
Brain Hypoxia Secondary to Diffusion Limitation in Hypoxic Ischemic Brain Injury Postcardiac Arrest. 61
31789834 2019
34
Neuroimaging provides relevant clinical information in patients with burn injuries. 61
31787472 2019
35
Interactions of benzodiazepines with heroin: Respiratory depression, temperature effects, and behavior. 61
31228487 2019
36
Hypoxia-induced biosynthesis of gold nanoparticles in the living brain. 61
31539009 2019
37
Effects of novel hexahydropyrimidine derivatives as potential ligands of M1 muscarinic acetylcholine receptor on cognitive function, hypoxia-induced lethality, and oxidative stress in rodents. 61
31340175 2019
38
"Females Are Not Just 'Protected' Males": Sex-Specific Vulnerabilities in Placenta and Brain after Prenatal Immune Disruption. 61
31611335 2019
39
Effects of the duration of postresuscitation hyperoxic ventilation on neurological outcome and survival in an asphyxial cardiac arrest rat model. 61
31712629 2019
40
Possible Mechanisms of Biological Effects Observed in Living Systems during 2H/1H Isotope Fractionation and Deuterium Interactions with Other Biogenic Isotopes. 61
31766268 2019
41
Thyroid Hormone Protects Primary Cortical Neurons Exposed to Hypoxia by Reducing DNA Methylation and Apoptosis. 61
31095291 2019
42
In chronic hypoxia, glucose availability and hypoxic severity dictate the balance between HIF-1 and HIF-2 in astrocytes. 61
31298941 2019
43
A practical approach to cerebral near-infrared spectroscopy (NIRS) directed hemodynamic management in noncardiac pediatric anesthesia. 61
31437328 2019
44
First-in-Human study of the Safety, Tolerability, Pharmacokinetics and - Preliminary Dynamics of Neuroprotectant 2-Iminobiotin in Healthy Subjects. 61
31625480 2019
45
Impact of CPAP on Forehead Near-infrared Spectroscopy Measurements in Patients With Acute Respiratory Failure: Truth or Illusion. 61
30015697 2019
46
Quantification of the severity of hypoxic-ischemic brain injury in a neonatal preclinical model using measurements of cytochrome-c-oxidase from a miniature broadband-near-infrared spectroscopy system. 61
31737744 2019
47
Intra- and interdialytic cerebral hypoxia: A culprit of cognitive decline going unpunished? 61
31034688 2019
48
Suppression of PDGF induces neuronal apoptosis after neonatal cerebral hypoxia and ischemia by inhibiting P-PI3K and P-AKT signaling pathways. 61
31082354 2019
49
Near-Infrared Spectroscopy Reveals Brain Hypoxia and Cerebrovascular Dysregulation in Primary Biliary Cholangitis. 61
31535726 2019
50
Continuous EEG monitoring after brain tumor surgery. 61
31278599 2019

Variations for Cerebral Hypoxia

Expression for Cerebral Hypoxia

Search GEO for disease gene expression data for Cerebral Hypoxia.

Pathways for Cerebral Hypoxia

Pathways related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.09 PTK2 ITGB1 ITGAV IGF1 CREB1 CASP9
2
Show member pathways
13.94 PTK2 NOS1 ITGB1 ITGAV FOS CREB1
3
Show member pathways
13.77 PTK2 ITGB1 ITGAV IGF1 FOS CREB1
4
Show member pathways
13.71 PTK2 ITGB1 ITGAV IGF1 FOS CREB1
5
Show member pathways
13.63 PTK2 ITGB1 ITGAV IGF1 FOS CREB1
6
Show member pathways
13.35 PTK2 ITGB1 ITGAV FOS CREB1 CASP3
7
Show member pathways
13.31 PTK2 ITGB1 ITGAV IGF1 FOS CREB1
8
Show member pathways
13.27 PTK2 NOS1 ITGB1 ITGAV IGF1 BCAR1
9
Show member pathways
13.24 PTK2 IGF1 FOS CASP9 CASP3
10
Show member pathways
12.98 PTK2 ITGB1 ITGAV IGF1 CREB1 CAMK4
11
Show member pathways
12.96 PTK2 IGF1 FOS CASP3 CAMK4 BCAR1
12
Show member pathways
12.89 PTK2 NOS1 ITGB1 ITGAV FOS BCAR1
13
Show member pathways
12.89 PTK2 ITGB1 ITGAV IGF1 CREB1 CASP9
14
Show member pathways
12.88 PTK2 ITGB1 IGF1 FOS BCAR1
15
Show member pathways
12.86 PTK2 ITGB1 ITGAV IGF1 FOS BCAR1
16
Show member pathways
12.83 PTK2 ITGAV FOS CREB1 CASP9 CASP3
17
Show member pathways
12.79 PTK2 ITGB1 ITGAV FOS CREB1 CAMK4
18
Show member pathways
12.77 IGF1 FOS CASP9 CASP3
19
Show member pathways
12.76 PTK2 ITGB1 ITGAV FOS CREB1 CAMK4
20
Show member pathways
12.74 PTK2 ITGB1 ITGAV IGF1 CREB1 CASP9
21
Show member pathways
12.73 NOS1 FOS CREB1 CAMK4
22 12.72 IGF1 FOS CASP9 CASP3
23 12.7 PTK2 ITGB1 ITGAV IGF1 FOS CASP9
24
Show member pathways
12.7 PTK2 ITGB1 IGF1 FOS CASP9 CASP3
25
Show member pathways
12.66 PTK2 IGF1 FOS CASP9 CAMK4
26
Show member pathways
12.61 PTK2 NOS1 IGF1 FOS CREB1 BCAR1
27 12.6 PTK2 ITGB1 ITGAV BCAR1
28
Show member pathways
12.58 PTK2 NOS1 ITGB1 FOS CASP9
29
Show member pathways
12.56 FOS CASP9 CASP3 BCAR1
30
Show member pathways
12.55 PTK2 IGF1 CASP9 BCAR1
31
Show member pathways
12.51 NOS1 FOS CREB1 CAMK4
32
Show member pathways
12.5 PTK2 FOS CASP9 CASP3 CAMK4
33
Show member pathways
12.5 PTK2 ITGB1 IGF1 FOS CREB1 CASP9
34
Show member pathways
12.47 PTK2 ITGB1 FOS CREB1 CASP3
35
Show member pathways
12.43 PTK2 ITGB1 ITGAV CASP9 CASP3
36
Show member pathways
12.39 IGF1 FOS CREB1 CASP9
37
Show member pathways
12.38 IGF1 CREB1 CASP9 CASP3
38
Show member pathways
12.38 ITGB1 ITGAV IGF1 FOS BCAR1
39
Show member pathways
12.38 PTK2 ITGAV FOS CREB1 CASP9
40 12.3 ITGB1 FOS CASP9 CASP3
41
Show member pathways
12.28 IGF1 CREB1 CAMK4
42 12.28 PTK2 ITGB1 ITGAV IGF1 CASP3
43
Show member pathways
12.26 ITGB1 FOS CASP9 CASP3
44
Show member pathways
12.22 FOS CASP9 CASP3
45
Show member pathways
12.22 ITGB1 ITGAV IGF1
46
Show member pathways
12.2 PTK2 ITGB1 ITGAV
47 12.2 CREB1 CASP9 CASP3
48 12.19 PTK2 FOS CREB1 BCAR1
49
Show member pathways
12.19 PTK2 ITGB1 FOS CREB1 CASP9 CASP3
50
Show member pathways
12.18 FOS CREB1 CASP3

GO Terms for Cerebral Hypoxia

Cellular components related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lamellipodium GO:0030027 9.43 PTK2 ITGB1 BCAR1
2 dendritic spine GO:0043197 9.33 PTK2 NOS1 ITGB1
3 integrin complex GO:0008305 9.32 ITGB1 ITGAV
4 focal adhesion GO:0005925 9.26 PTK2 ITGB1 ITGAV BCAR1
5 alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867 8.62 ITGAV IGF1

Biological processes related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.91 PTK2 ITGB1 ITGAV IGF1
2 positive regulation of transcription, DNA-templated GO:0045893 9.88 NOS1 IGF1 FOS CREB1 CAMK4
3 positive regulation of apoptotic process GO:0043065 9.8 ITGB1 CREB1 CASP9 CASP3
4 aging GO:0007568 9.78 FOS CREB1 CASP9
5 response to hypoxia GO:0001666 9.77 NOS1 CREB1 CASP3
6 response to organic cyclic compound GO:0014070 9.69 FOS CASP9 CASP3
7 ERK1 and ERK2 cascade GO:0070371 9.63 ITGAV IGF1
8 response to antibiotic GO:0046677 9.62 CASP9 CASP3
9 heterotypic cell-cell adhesion GO:0034113 9.62 ITGB1 ITGAV
10 response to lipopolysaccharide GO:0032496 9.62 NOS1 FOS CASP9 CASP3
11 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.61 PTK2 ITGAV BCAR1
12 positive regulation of cardiac muscle hypertrophy GO:0010613 9.6 PTK2 IGF1
13 positive regulation of osteoclast differentiation GO:0045672 9.58 FOS CREB1
14 cell adhesion mediated by integrin GO:0033627 9.58 ITGB1 ITGAV
15 neurotrophin TRK receptor signaling pathway GO:0048011 9.57 CASP3 BCAR1
16 platelet formation GO:0030220 9.56 CASP9 CASP3
17 cell-substrate adhesion GO:0031589 9.55 ITGB1 ITGAV
18 negative regulation of anoikis GO:2000811 9.54 PTK2 ITGB1
19 cellular response to hepatocyte growth factor stimulus GO:0035729 9.52 CREB1 BCAR1
20 response to cobalt ion GO:0032025 9.46 CASP9 CASP3
21 transforming growth factor beta receptor signaling pathway GO:0007179 9.46 PTK2 ITGB1 FOS CREB1
22 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.43 ITGAV CASP9 CASP3
23 leukocyte apoptotic process GO:0071887 9.4 CASP9 CASP3
24 glial cell apoptotic process GO:0034349 9.37 CASP9 CASP3
25 integrin-mediated signaling pathway GO:0007229 9.26 PTK2 ITGB1 ITGAV BCAR1
26 positive regulation of cell migration GO:0030335 9.02 PTK2 ITGB1 ITGAV IGF1 BCAR1

Molecular functions related to Cerebral Hypoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.5 ITGB1 ITGAV IGF1
2 fibronectin binding GO:0001968 9.37 ITGB1 ITGAV
3 protease binding GO:0002020 9.33 ITGB1 ITGAV CASP3
4 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.26 CASP9 CASP3
5 cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097199 8.96 CASP9 CASP3
6 C-X3-C chemokine binding GO:0019960 8.62 ITGB1 ITGAV

Sources for Cerebral Hypoxia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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