MCID: CRB001
MIFTS: 32

Cerebral Lymphoma

Categories: Cancer diseases, Neuronal diseases, Immune diseases

Aliases & Classifications for Cerebral Lymphoma

MalaCards integrated aliases for Cerebral Lymphoma:

Name: Cerebral Lymphoma 12 15
Primary Cerebral Lymphoma 12 73
Primary Lymphoma of Cerebrum 12
Brain Primary Lymphoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5815
NCIt 50 C7611
SNOMED-CT 68 276836002
UMLS 73 C0240803

Summaries for Cerebral Lymphoma

Disease Ontology : 12 A cerebrum cancer that affects the lymph cells and derives from the brain.

MalaCards based summary : Cerebral Lymphoma, also known as primary cerebral lymphoma, is related to primary central nervous system lymphoma and lymphoma. An important gene associated with Cerebral Lymphoma is SST (Somatostatin). The drugs rituximab and Dacarbazine have been mentioned in the context of this disorder. Affiliated tissues include brain, b cells and kidney.

Related Diseases for Cerebral Lymphoma

Diseases related to Cerebral Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 primary central nervous system lymphoma 10.9
2 lymphoma 10.5
3 cerebritis 10.5
4 stomach disease 10.3 SST TLR9
5 pernicious anemia 10.2 SST TCN2
6 glucose metabolism disease 10.2 SST TLR9
7 acquired metabolic disease 10.1 SST TLR9
8 gastrointestinal neuroendocrine tumor 10.1 SMUG1 SST
9 parasitic protozoa infectious disease 10.1 TCN2 TLR9
10 ectopic cushing syndrome 10.1 SMUG1 SST
11 central nervous system vasculitis 10.0 SMUG1 TLR9
12 gastrointestinal system disease 10.0 SST TLR9
13 hypersensitivity reaction type iv disease 10.0 SMUG1 TLR9
14 female reproductive organ cancer 10.0 SMUG1 TLR9
15 endocrine gland cancer 10.0 SMUG1 SST
16 respiratory system cancer 10.0 SMUG1 TLR9
17 cell type cancer 9.9 SMUG1 TLR9
18 gastrointestinal system cancer 9.8 SMUG1 TLR9
19 glioblastoma 9.8
20 acquired immunodeficiency syndrome 9.8
21 encephalitis 9.8
22 central nervous system disease 9.7 SMUG1 TLR9
23 nervous system disease 9.7 SMUG1 TLR9
24 glioma susceptibility 1 9.6
25 systemic lupus erythematosus 9.6
26 glioblastoma multiforme 9.6
27 lupus erythematosus 9.6
28 toxoplasmosis 9.6
29 thyroid cancer, nonmedullary, 2 9.6 SMUG1 SST
30 multiple sclerosis 9.5
31 combined immunodeficiency, x-linked 9.5
32 membranous nephropathy 9.5
33 autoimmune lymphoproliferative syndrome, type v 9.5
34 intraocular lymphoma 9.5
35 leukemia 9.5
36 severe combined immunodeficiency 9.5
37 dementia 9.5
38 polyneuropathy 9.5
39 encephalomalacia 9.5
40 oligodendroglioma 9.5
41 craniopharyngioma 9.5
42 chiasmal syndrome 9.5
43 adenosine deaminase deficiency 9.5
44 herpes simplex 9.5
45 neuropathy 9.5
46 diabetes insipidus 9.5
47 meningitis 9.5
48 anaplastic oligodendroglioma 9.5
49 glioma 9.5
50 tuberculous meningitis 9.5

Graphical network of the top 20 diseases related to Cerebral Lymphoma:



Diseases related to Cerebral Lymphoma

Symptoms & Phenotypes for Cerebral Lymphoma

Drugs & Therapeutics for Cerebral Lymphoma

Drugs for Cerebral Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 2,Phase 1 174722-31-7 10201696
2
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
3
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
4
Methotrexate Approved Phase 2,Phase 1 1959-05-2, 59-05-2 126941
5
Procarbazine Approved, Investigational Phase 2 671-16-9 4915
6
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
7
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
8
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
9
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
10
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
11
leucovorin Approved, Nutraceutical Phase 2,Phase 1 58-05-9 143 6006
12
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2,Phase 1 59-30-3 6037
13
Doxil Approved June 1999 Phase 2 31703
14 Alkylating Agents Phase 2
15 Folic Acid Antagonists Phase 2,Phase 1
16 Dermatologic Agents Phase 2,Phase 1
17 Nucleic Acid Synthesis Inhibitors Phase 2,Phase 1
18 Vitamin B Complex Phase 2,Phase 1
19 Immunosuppressive Agents Phase 2,Phase 1
20 Anti-Infective Agents Phase 2
21 Antirheumatic Agents Phase 2,Phase 1
22 Antimetabolites Phase 2,Phase 1
23 Antiviral Agents Phase 2
24 Antimetabolites, Antineoplastic Phase 2,Phase 1
25 Antimitotic Agents Phase 2
26 Antineoplastic Agents, Alkylating Phase 2
27 Antineoplastic Agents, Phytogenic Phase 2
28 Calcium, Dietary Phase 2
29 Dexamethasone acetate Phase 2 1177-87-3
30 glucocorticoids Phase 2
31
protease inhibitors Phase 2
32 Gastrointestinal Agents Phase 2
33 HIV Protease Inhibitors Phase 2
34 Topoisomerase Inhibitors Phase 2
35 Hormone Antagonists Phase 2
36 Hormones Phase 2
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
38 Peripheral Nervous System Agents Phase 2
39 Anti-Bacterial Agents Phase 2
40 Antibiotics, Antitubercular Phase 2
41 Antiemetics Phase 2
42 Anti-Inflammatory Agents Phase 2
43 BB 1101 Phase 2
44 Autonomic Agents Phase 2
45 Antineoplastic Agents, Hormonal Phase 2
46 Folate Nutraceutical Phase 2,Phase 1
47 Vitamin B9 Nutraceutical Phase 2,Phase 1
48
Pemetrexed Approved, Investigational Phase 1 150399-23-8, 137281-23-3 446556 60843

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study to Evaluate the Combination of Rituximab and DepoCyte® in the C5R Chemotherapy Protocol in Patients Between the Ages of 18 and 60 Years With Primary Cerebral Non-Hodgkin Lymphoma and Systemic Diffuse Large B-cell Lymphoma With Neuromeningea Unknown status NCT00553943 Phase 2 Rituximab, Cytarabine
2 Methotrexate and Temozolomide Versus Methotrexate, Procarbazine, Vincristine and Cytarabine Unknown status NCT00503594 Phase 2 Methotrexate and temozolomide;Methotrexate , procarbazine ,vincristine ,cytarabine
3 Chemotherapy and HAART to Treat AIDS-related Primary Brain Lymphoma Recruiting NCT00267865 Phase 2 Methotrexate;Rituximab;Leucovorin
4 Phase II Study Evaluating a Combination of Pegylated Liposomal Doxorubicin and Dexamethasone for the Treatment of Immunocompetent Patients With Cerebral Lymphoma Relapsed or Refractory to First-line Chemotherapy With High Dose Methotrexate (MTXHD) and / o Terminated NCT01848652 Phase 2 infusion of MYOCET
5 A Safety Study of Rituximab Plus MTX Injected Into the Cerebrospinal Fluid in the Treatment of Brain Lymphoma Completed NCT00221325 Phase 1 Intraventricular Rituximab Plus MTX
6 Treatment of Recurrent Primary or Secondary Central Nervous System (CNS) Lymphoma With ALIMTA (Pemetrexed) Completed NCT00916630 Phase 1 pemetrexed
7 Role of [18F]-FDG Brain PET in Newly Diagnosed Primary Cerebral Lymphoma, in Immunocompetent Patient Older Than 60 Years Recruiting NCT03582254 Not Applicable
8 Lactate Imaging as a Tumour Biomarker Active, not recruiting NCT01881386

Search NIH Clinical Center for Cerebral Lymphoma

Genetic Tests for Cerebral Lymphoma

Anatomical Context for Cerebral Lymphoma

MalaCards organs/tissues related to Cerebral Lymphoma:

41
Brain, B Cells, Kidney, Eye, Testes

Publications for Cerebral Lymphoma

Articles related to Cerebral Lymphoma:

(show top 50) (show all 120)
# Title Authors Year
1
Differentiation between Glioblastoma Multiforme and Primary Cerebral Lymphoma: Additional Benefits of Quantitative Diffusion-Weighted MR Imaging. ( 27631626 )
2016
2
Fluorescein sodium-guided surgery in cerebral lymphoma. ( 26432995 )
2015
3
Brain lesions in a long-term kidney transplant recipient: Primary cerebral lymphoma or cerebral toxoplasmosis? ( 26383060 )
2015
4
Cerebral Lymphoma in a Kidney Transplant: A Case Report. ( 26030159 )
2015
5
Non-invasive assessment of intratumoral vascularity using arterial spin labeling: A comparison to susceptibility-weighted imaging for the differentiation of primary cerebral lymphoma and glioblastoma. ( 24613549 )
2014
6
Chronic cough as a presenting feature of cerebral lymphoma. ( 25344556 )
2014
7
Differentiation between Primary Cerebral Lymphoma and Glioblastoma Using the Apparent Diffusion Coefficient: Comparison of Three Different ROI Methods. ( 25393543 )
2014
8
Primary cerebral lymphoma with spontaneous remission. ( 22037213 )
2013
9
Utility of FDG-PETCT and magnetic resonance spectroscopy in differentiating between cerebral lymphoma and non-malignant CNS lesions in HIV-infected patients. ( 23578921 )
2013
10
Does adding FDG-PET to MRI improve the differentiation between primary cerebral lymphoma and glioblastoma? Observer performance study. ( 21404136 )
2011
11
Fatal septicemia in a patient with cerebral lymphoma and an Amplatzer septal occluder: a case report. ( 22115504 )
2011
12
Imaging diagnosis-magnetic resonance imaging features of metastatic cerebral lymphoma in a dog. ( 21388473 )
2011
13
EBV related cerebral lymphoma in a leukemia patient treated with alemtuzumab. ( 21136270 )
2011
14
An atypical case of X-linked lymphoproliferative disease revealed as a late cerebral lymphoma. ( 19906447 )
2010
15
Therapeutic drug monitoring for busulfan in plasma during conditioning chemotherapy for autologous stem cell transplantation in relapsed primary cerebral lymphoma. ( 20386358 )
2010
16
Metallothionein-I + II and receptor megalin are altered in relation to oxidative stress in cerebral lymphomas. ( 20038220 )
2010
17
EBV-positive B cell cerebral lymphoma 12 years after sex-mismatched kidney transplantation: post-transplant lymphoproliferative disorder or donor-derived lymphoma? ( 20348150 )
2010
18
Primary cerebral lymphoma with a 5-year remission to single-agent corticosteroids. ( 19637089 )
2009
19
Monoclonal gammopathy as a marker of primary cerebral lymphoma. ( 19453652 )
2009
20
A spontaneously vanishing primary cerebral lymphoma "ghost tumour". ( 18796594 )
2008
21
Primary cerebral lymphoma and glioblastoma multiforme: differences in diffusion characteristics evaluated with diffusion tensor imaging. ( 18065516 )
2008
22
Importance of functional MRI and the role of stereotactic biopsy in the diagnosis of cerebral lymphoma. ( 24256963 )
2008
23
Cerebral lymphoma: clinical and radiological findings in 90 cases. ( 17367223 )
2007
24
Primary cerebral lymphoma: clinical and aeromedical considerations. ( 17484350 )
2007
25
Contiguous synchronous occurrence of primary cerebral lymphoma and meningioma. ( 17453773 )
2007
26
Highly active antiretroviral therapy and human immunodeficiency virus-associated primary cerebral lymphoma. ( 16882946 )
2006
27
Cerebral lymphoma in an adenosine deaminase-deficient patient with severe combined immunodeficiency receiving polyethylene glycol-conjugated adenosine deaminase. ( 16263974 )
2005
28
Phenotypic APC resistance as a marker of hypercoagulability in primitive cerebral lymphoma. ( 15995637 )
2005
29
Side effects related to cancer treatment: CASE 3. Primary cerebral lymphoma after radiotherapy for recurrent meningioma. ( 16293883 )
2005
30
Atypical manifestation of childhood primary cerebral lymphoma restricted to the leptomeninges. ( 16044275 )
2005
31
Changing pattern of primary cerebral lymphoma in the highly active antiretroviral therapy era. ( 16540454 )
2005
32
Intraocular lymphoma as a masquerade syndrome complicating cerebral lymphoma of the corpus callosum. ( 15558282 )
2005
33
Clinical response following adjuvant Temozolomide in a patient with primary cerebral lymphoma. ( 15736462 )
2004
34
Primary cerebral lymphoma: a retrospective study in 22 immunocompetent patients. ( 15315308 )
2004
35
Reversible choreoathetosis in primary cerebral lymphoma: clinicoradiologic correlation. ( 12824713 )
2003
36
Diffusion-weighted imaging and single-voxel MR spectroscopy in a case of malignant cerebral lymphoma. ( 14605786 )
2003
37
Primary cerebral lymphoma presenting as diffuse leukoencephalopathy. ( 12700473 )
2003
38
Distinguishing of primary cerebral lymphoma from high-grade glioma with perfusion-weighted magnetic resonance imaging. ( 12566167 )
2003
39
Selective circadian rhythm disturbance in cerebral lymphoma. ( 14607354 )
2003
40
B cell non-Hodgkin cerebral lymphoma associated with an anaplastic oligodendroglioma. ( 12489671 )
2002
41
Primary cerebral lymphoma and membranous nephropathy: a still unreported association. ( 12046053 )
2002
42
Cerebral lymphoma presenting as a leukoencephalopathy. ( 11459903 )
2001
43
Central neurogenic hyperventilation with primary cerebral lymphoma: a case report. ( 11550722 )
2001
44
Acquired immunodeficiency syndrome-related primary cerebral lymphoma: response to irradiation. ( 10849981 )
2000
45
Giant anterior communicating artery aneurysm infiltrated with a primary cerebral lymphoma: case report. ( 10942022 )
2000
46
Ocular and fulminant cerebral lymphoma in AIDS. ( 10454187 )
1999
47
Treatment outcome in presumed and confirmed AIDS-related primary cerebral lymphoma. ( 10492634 )
1999
48
HIV-related primary cerebral lymphoma: the role of stereotactic biopsy. ( 10835171 )
1999
49
Acquired immunodeficiency syndrome-related primary cerebral lymphoma. ( 10194581 )
1999
50
Magnetic resonance imaging, thallium-201 SPET scanning, and laboratory analyses for discrimination of cerebral lymphoma and toxoplasmosis in AIDS. ( 9924465 )
1998

Variations for Cerebral Lymphoma

Expression for Cerebral Lymphoma

Search GEO for disease gene expression data for Cerebral Lymphoma.

Pathways for Cerebral Lymphoma

GO Terms for Cerebral Lymphoma

Sources for Cerebral Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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