MCID: CRB001
MIFTS: 32

Cerebral Lymphoma

Categories: Cancer diseases, Immune diseases, Neuronal diseases

Aliases & Classifications for Cerebral Lymphoma

MalaCards integrated aliases for Cerebral Lymphoma:

Name: Cerebral Lymphoma 12 15
Primary Cerebral Lymphoma 12 73
Primary Lymphoma of Cerebrum 12
Brain Primary Lymphoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5815
NCIt 50 C7611
UMLS 73 C0240803

Summaries for Cerebral Lymphoma

Disease Ontology : 12 A cerebrum cancer that affects the lymph cells and derives from the brain.

MalaCards based summary : Cerebral Lymphoma, also known as primary cerebral lymphoma, is related to primary central nervous system lymphoma and lymphoma. An important gene associated with Cerebral Lymphoma is SST (Somatostatin). The drugs Methotrexate and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include brain, b cells and monocytes.

Related Diseases for Cerebral Lymphoma

Diseases related to Cerebral Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 primary central nervous system lymphoma 11.1
2 lymphoma 10.6
3 pernicious anemia 10.1 SST TCN2
4 stomach disease 10.1 SST TLR9
5 glucose metabolism disease 10.1 SST TLR9
6 gastrointestinal neuroendocrine tumor 10.0 SMUG1 SST
7 parasitic protozoa infectious disease 10.0 TCN2 TLR9
8 acquired metabolic disease 10.0 SST TLR9
9 ectopic cushing syndrome 10.0 SMUG1 SST
10 thyroid gland disease 10.0 SMUG1 SST
11 central nervous system vasculitis 10.0 SMUG1 TLR9
12 hypersensitivity reaction type iv disease 10.0 SMUG1 TLR9
13 lymphatic system disease 10.0 SMUG1 TLR9
14 cervix disease 10.0 SMUG1 TLR9
15 uterine anomalies 10.0 SMUG1 TLR9
16 leukocyte disease 10.0 SMUG1 TLR9
17 female reproductive system disease 10.0 SMUG1 TLR9
18 megaloblastic anemia 10.0 TCN2 TLR9
19 reproductive system disease 10.0 SMUG1 TLR9
20 respiratory system cancer 10.0 SMUG1 TLR9
21 intestinal disease 10.0 SMUG1 TLR9
22 respiratory system disease 9.9 SMUG1 TLR9
23 glioblastoma 9.9
24 meningioma, familial 9.9 SMUG1 SST
25 gastrointestinal system cancer 9.9 SMUG1 TLR9
26 thyroid cancer, nonmedullary, 2 9.9 SMUG1 SST
27 acquired immunodeficiency syndrome 9.9
28 encephalitis 9.9
29 anus cancer 9.9 SETD1A SMUG1
30 endocrine gland cancer 9.9 SMUG1 SST TLR9
31 gastrointestinal system disease 9.9 SMUG1 SST TLR9
32 pancreas adenocarcinoma 9.9 SMUG1 SST
33 nervous system disease 9.8 SMUG1 TLR9
34 glioma susceptibility 1 9.7
35 systemic lupus erythematosus 9.7
36 glioblastoma multiforme 9.7
37 lupus erythematosus 9.7
38 toxoplasmosis 9.7
39 multiple sclerosis 9.6
40 membranous nephropathy 9.6
41 intraocular lymphoma 9.6
42 leukemia 9.6
43 post-transplant lymphoproliferative disease 9.6
44 severe combined immunodeficiency 9.6
45 dementia 9.6
46 polyneuropathy 9.6
47 encephalomalacia 9.6
48 oligodendroglioma 9.6
49 craniopharyngioma 9.6
50 chiasmal syndrome 9.6

Graphical network of the top 20 diseases related to Cerebral Lymphoma:



Diseases related to Cerebral Lymphoma

Symptoms & Phenotypes for Cerebral Lymphoma

Drugs & Therapeutics for Cerebral Lymphoma

Drugs for Cerebral Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 2,Phase 1,Not Applicable 59-05-2, 1959-05-2 126941
2
Vincristine Approved, Investigational Phase 2,Not Applicable 57-22-7, 2068-78-2 5978
3
Procarbazine Approved, Investigational Phase 2,Not Applicable 671-16-9 4915
4
leucovorin Approved Phase 2,Phase 1 58-05-9 6006 143
5
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
6
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
7
Cytarabine Approved, Investigational Phase 2,Not Applicable 147-94-4 6253
8
rituximab Approved Phase 2,Phase 1,Not Applicable 174722-31-7 10201696
9
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
10
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
11
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
12
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
13
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2,Phase 1 59-30-3 6037
14
Doxil Approved June 1999 Phase 2 31703
15 Dermatologic Agents Phase 2,Phase 1
16 Nucleic Acid Synthesis Inhibitors Phase 2,Phase 1
17 Antirheumatic Agents Phase 2,Phase 1
18 Antiviral Agents Phase 2
19 Antineoplastic Agents, Alkylating Phase 2
20 Alkylating Agents Phase 2
21 Vitamin B Complex Phase 2,Phase 1
22 Immunologic Factors Phase 2,Phase 1
23 Folic Acid Antagonists Phase 2,Phase 1
24 Anti-Infective Agents Phase 2
25 Antimetabolites Phase 2,Phase 1
26 Antimitotic Agents Phase 2
27 Immunosuppressive Agents Phase 2,Phase 1
28 Antineoplastic Agents, Phytogenic Phase 2
29 Antimetabolites, Antineoplastic Phase 2,Phase 1
30 Folate Phase 2,Phase 1
31 Vitamin B9 Phase 2,Phase 1
32 Calcium, Dietary Phase 2
33
protease inhibitors Phase 2
34 BB 1101 Phase 2
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
36 Hormones Phase 2
37 Peripheral Nervous System Agents Phase 2
38 Antibiotics, Antitubercular Phase 2
39 Hormone Antagonists Phase 2
40 Antineoplastic Agents, Hormonal Phase 2
41 Autonomic Agents Phase 2
42 Antiemetics Phase 2
43 Anti-Bacterial Agents Phase 2
44 Topoisomerase Inhibitors Phase 2
45 HIV Protease Inhibitors Phase 2
46 Gastrointestinal Agents Phase 2
47 glucocorticoids Phase 2
48 Anti-Inflammatory Agents Phase 2
49
Pemetrexed Approved, Investigational Phase 1 150399-23-8, 137281-23-3 446556 60843

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Methotrexate and Temozolomide Versus Methotrexate, Procarbazine, Vincristine and Cytarabine Unknown status NCT00503594 Phase 2 Methotrexate and temozolomide;Methotrexate , procarbazine ,vincristine ,cytarabine
2 Phase II Study to Evaluate the Combination of Rituximab and DepoCyte® in the C5R Chemotherapy Protocol in Patients Between the Ages of 18 and 60 Years With Primary Cerebral Non-Hodgkin Lymphoma and Systemic Diffuse Large B-cell Lymphoma With Neuromeningeal Invasion at Diagnosis Completed NCT00553943 Phase 2 Rituximab;Cytarabine
3 Chemotherapy and HAART to Treat AIDS-related Primary Brain Lymphoma Recruiting NCT00267865 Phase 2 Methotrexate;Rituximab;Leucovorin
4 Copanlisib With Ibrutinib for Patients With Recurrent/ Refractory Primary Central Nervous System Lymphoma (PCNSL) Recruiting NCT03581942 Phase 1, Phase 2 Ibrutinib;Copanlisib
5 Phase II Study Evaluating a Combination of Pegylated Liposomal Doxorubicin and Dexamethasone for the Treatment of Immunocompetent Patients With Cerebral Lymphoma Relapsed or Refractory to First-line Chemotherapy With High Dose Methotrexate (MTXHD) and / or High-dose Cytarabine. Terminated NCT01848652 Phase 2 infusion of MYOCET
6 A Safety Study of Rituximab Plus MTX Injected Into the Cerebrospinal Fluid in the Treatment of Brain Lymphoma Completed NCT00221325 Phase 1 Intraventricular Rituximab Plus MTX
7 Treatment of Recurrent Primary or Secondary Central Nervous System (CNS) Lymphoma With ALIMTA (Pemetrexed) Completed NCT00916630 Phase 1 pemetrexed
8 Role of [18F]-FDG Brain PET in Newly Diagnosed Primary Cerebral Lymphoma, in Immunocompetent Patient Older Than 60 Years Recruiting NCT03582254 Not Applicable
9 SMOLY : Phenotype and Functions of Monocyte Subtypes in High Grade B Lymphoma: Towards New Biomarkers? Active, not recruiting NCT03672682
10 Lactate Imaging as a Tumour Biomarker Active, not recruiting NCT01881386
11 Integrated Discovery of New Immuno-Molecular Actionable Biomarkers for Tumors With Immune-suppressed Environment Not yet recruiting NCT03706625

Search NIH Clinical Center for Cerebral Lymphoma

Genetic Tests for Cerebral Lymphoma

Anatomical Context for Cerebral Lymphoma

MalaCards organs/tissues related to Cerebral Lymphoma:

41
Brain, B Cells, Monocytes, Kidney, Cervix, Thyroid, T Cells

Publications for Cerebral Lymphoma

Articles related to Cerebral Lymphoma:

(show top 50) (show all 119)
# Title Authors Year
1
Differentiation between Glioblastoma Multiforme and Primary Cerebral Lymphoma: Additional Benefits of Quantitative Diffusion-Weighted MR Imaging. ( 27631626 )
2016
2
Fluorescein sodium-guided surgery in cerebral lymphoma. ( 26432995 )
2015
3
Brain lesions in a long-term kidney transplant recipient: Primary cerebral lymphoma or cerebral toxoplasmosis? ( 26383060 )
2015
4
Cerebral Lymphoma in a Kidney Transplant: A Case Report. ( 26030159 )
2015
5
Non-invasive assessment of intratumoral vascularity using arterial spin labeling: A comparison to susceptibility-weighted imaging for the differentiation of primary cerebral lymphoma and glioblastoma. ( 24613549 )
2014
6
Chronic cough as a presenting feature of cerebral lymphoma. ( 25344556 )
2014
7
Differentiation between Primary Cerebral Lymphoma and Glioblastoma Using the Apparent Diffusion Coefficient: Comparison of Three Different ROI Methods. ( 25393543 )
2014
8
Primary cerebral lymphoma with spontaneous remission. ( 22037213 )
2013
9
Utility of FDG-PETCT and magnetic resonance spectroscopy in differentiating between cerebral lymphoma and non-malignant CNS lesions in HIV-infected patients. ( 23578921 )
2013
10
Does adding FDG-PET to MRI improve the differentiation between primary cerebral lymphoma and glioblastoma? Observer performance study. ( 21404136 )
2011
11
Fatal septicemia in a patient with cerebral lymphoma and an Amplatzer septal occluder: a case report. ( 22115504 )
2011
12
Imaging diagnosis-magnetic resonance imaging features of metastatic cerebral lymphoma in a dog. ( 21388473 )
2011
13
EBV related cerebral lymphoma in a leukemia patient treated with alemtuzumab. ( 21136270 )
2011
14
An atypical case of X-linked lymphoproliferative disease revealed as a late cerebral lymphoma. ( 19906447 )
2010
15
Therapeutic drug monitoring for busulfan in plasma during conditioning chemotherapy for autologous stem cell transplantation in relapsed primary cerebral lymphoma. ( 20386358 )
2010
16
EBV-positive B cell cerebral lymphoma 12 years after sex-mismatched kidney transplantation: post-transplant lymphoproliferative disorder or donor-derived lymphoma? ( 20348150 )
2010
17
Primary cerebral lymphoma with a 5-year remission to single-agent corticosteroids. ( 19637089 )
2009
18
Monoclonal gammopathy as a marker of primary cerebral lymphoma. ( 19453652 )
2009
19
A spontaneously vanishing primary cerebral lymphoma "ghost tumour". ( 18796594 )
2008
20
Primary cerebral lymphoma and glioblastoma multiforme: differences in diffusion characteristics evaluated with diffusion tensor imaging. ( 18065516 )
2008
21
Importance of functional MRI and the role of stereotactic biopsy in the diagnosis of cerebral lymphoma. ( 24256963 )
2008
22
Cerebral lymphoma: clinical and radiological findings in 90 cases. ( 17367223 )
2007
23
Primary cerebral lymphoma: clinical and aeromedical considerations. ( 17484350 )
2007
24
Contiguous synchronous occurrence of primary cerebral lymphoma and meningioma. ( 17453773 )
2007
25
Highly active antiretroviral therapy and human immunodeficiency virus-associated primary cerebral lymphoma. ( 16882946 )
2006
26
Cerebral lymphoma in an adenosine deaminase-deficient patient with severe combined immunodeficiency receiving polyethylene glycol-conjugated adenosine deaminase. ( 16263974 )
2005
27
Phenotypic APC resistance as a marker of hypercoagulability in primitive cerebral lymphoma. ( 15995637 )
2005
28
Side effects related to cancer treatment: CASE 3. Primary cerebral lymphoma after radiotherapy for recurrent meningioma. ( 16293883 )
2005
29
Atypical manifestation of childhood primary cerebral lymphoma restricted to the leptomeninges. ( 16044275 )
2005
30
Changing pattern of primary cerebral lymphoma in the highly active antiretroviral therapy era. ( 16540454 )
2005
31
Intraocular lymphoma as a masquerade syndrome complicating cerebral lymphoma of the corpus callosum. ( 15558282 )
2005
32
Clinical response following adjuvant Temozolomide in a patient with primary cerebral lymphoma. ( 15736462 )
2004
33
Primary cerebral lymphoma: a retrospective study in 22 immunocompetent patients. ( 15315308 )
2004
34
Reversible choreoathetosis in primary cerebral lymphoma: clinicoradiologic correlation. ( 12824713 )
2003
35
Diffusion-weighted imaging and single-voxel MR spectroscopy in a case of malignant cerebral lymphoma. ( 14605786 )
2003
36
Primary cerebral lymphoma presenting as diffuse leukoencephalopathy. ( 12700473 )
2003
37
Distinguishing of primary cerebral lymphoma from high-grade glioma with perfusion-weighted magnetic resonance imaging. ( 12566167 )
2003
38
Selective circadian rhythm disturbance in cerebral lymphoma. ( 14607354 )
2003
39
B cell non-Hodgkin cerebral lymphoma associated with an anaplastic oligodendroglioma. ( 12489671 )
2002
40
Primary cerebral lymphoma and membranous nephropathy: a still unreported association. ( 12046053 )
2002
41
Cerebral lymphoma presenting as a leukoencephalopathy. ( 11459903 )
2001
42
Central neurogenic hyperventilation with primary cerebral lymphoma: a case report. ( 11550722 )
2001
43
Acquired immunodeficiency syndrome-related primary cerebral lymphoma: response to irradiation. ( 10849981 )
2000
44
Giant anterior communicating artery aneurysm infiltrated with a primary cerebral lymphoma: case report. ( 10942022 )
2000
45
Ocular and fulminant cerebral lymphoma in AIDS. ( 10454187 )
1999
46
Treatment outcome in presumed and confirmed AIDS-related primary cerebral lymphoma. ( 10492634 )
1999
47
HIV-related primary cerebral lymphoma: the role of stereotactic biopsy. ( 10835171 )
1999
48
Acquired immunodeficiency syndrome-related primary cerebral lymphoma. ( 10194581 )
1999
49
Magnetic resonance imaging, thallium-201 SPET scanning, and laboratory analyses for discrimination of cerebral lymphoma and toxoplasmosis in AIDS. ( 9924465 )
1998
50
Methotrexate for suspected cerebral lymphoma in AIDS. ( 9677177 )
1998

Variations for Cerebral Lymphoma

Expression for Cerebral Lymphoma

Search GEO for disease gene expression data for Cerebral Lymphoma.

Pathways for Cerebral Lymphoma

GO Terms for Cerebral Lymphoma

Sources for Cerebral Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....