MCID: CRB001
MIFTS: 40

Cerebral Lymphoma

Categories: Cancer diseases, Immune diseases, Neuronal diseases

Aliases & Classifications for Cerebral Lymphoma

MalaCards integrated aliases for Cerebral Lymphoma:

Name: Cerebral Lymphoma 12 15
Primary Cerebral Lymphoma 12 74
Primary Lymphoma of Cerebrum 12
Brain Primary Lymphoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5815
NCIt 51 C7611
UMLS 74 C0240803

Summaries for Cerebral Lymphoma

Disease Ontology : 12 A cerebrum cancer that affects the lymph cells and derives from the brain.

MalaCards based summary : Cerebral Lymphoma, also known as primary cerebral lymphoma, is related to primary central nervous system lymphoma and lymphoma. An important gene associated with Cerebral Lymphoma is SST (Somatostatin), and among its related pathways/superpathways are Peptide ligand-binding receptors and cAMP signaling pathway. The drugs leucovorin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and b cells, and related phenotype is homeostasis/metabolism.

Related Diseases for Cerebral Lymphoma

Diseases related to Cerebral Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 primary central nervous system lymphoma 11.1
2 lymphoma 10.7
3 ectopic cushing syndrome 10.1 SST SSTR1
4 type c thymoma 10.1 SST SSTR2
5 carcinoid tumors, intestinal 10.1 SST SSTR2
6 growth hormone secreting pituitary adenoma 10.1 SST SSTR2
7 functioning pituitary adenoma 10.1 SST SSTR5
8 serotonin syndrome 10.1 SST SSTR1
9 mixed ductal-endocrine carcinoma 10.0 SST SSTR2
10 pituitary tumors 10.0 SST SSTR5
11 cell type benign neoplasm 10.0 SST SSTR5
12 neuroendocrine tumor 10.0 SST SSTR2
13 acquired immunodeficiency syndrome 10.0
14 glioblastoma 10.0
15 meningioma, familial 9.9 SST SSTR2
16 encephalitis 9.9
17 thyroid cancer, nonmedullary, 2 9.9 SST SSTR2
18 oncogenic osteomalacia 9.8 SSTR1 SSTR3 SSTR5
19 hormone producing pituitary cancer 9.8 SST SSTR2 SSTR5
20 pancreatic endocrine carcinoma 9.8 SST SSTR2 SSTR5
21 glioma susceptibility 1 9.8
22 systemic lupus erythematosus 9.8
23 intraocular lymphoma 9.8
24 glioblastoma multiforme 9.8
25 lupus erythematosus 9.8
26 toxoplasmosis 9.8
27 small cell cancer of the lung 9.8 SST SSTR2
28 multiple sclerosis 9.6
29 membranous nephropathy 9.6
30 leukemia 9.6
31 post-transplant lymphoproliferative disease 9.6
32 severe combined immunodeficiency 9.6
33 lymphoproliferative syndrome 9.6
34 dementia 9.6
35 polyneuropathy 9.6
36 encephalomalacia 9.6
37 wernicke encephalopathy 9.6
38 cystadenoma 9.6
39 oligodendroglioma 9.6
40 craniopharyngioma 9.6
41 chiasmal syndrome 9.6
42 combined t cell and b cell immunodeficiency 9.6
43 herpes simplex 9.6
44 neuropathy 9.6
45 diabetes insipidus 9.6
46 meningitis 9.6
47 anaplastic oligodendroglioma 9.6
48 glioma 9.6
49 tuberculous meningitis 9.6
50 encephalopathy 9.6

Graphical network of the top 20 diseases related to Cerebral Lymphoma:



Diseases related to Cerebral Lymphoma

Symptoms & Phenotypes for Cerebral Lymphoma

MGI Mouse Phenotypes related to Cerebral Lymphoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.1 SLC19A1 SST SSTR1 SSTR2 SSTR5 SYNE1

Drugs & Therapeutics for Cerebral Lymphoma

Drugs for Cerebral Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 2,Phase 1 58-05-9 143 6006
2
Methotrexate Approved Phase 2,Phase 1,Not Applicable 1959-05-2, 59-05-2 126941
3
Cytarabine Approved, Experimental, Investigational Phase 2,Not Applicable 147-94-4, 65-46-3 6253
4
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
5
Vincristine Approved, Investigational Phase 2,Not Applicable 2068-78-2, 57-22-7 5978
6
Procarbazine Approved, Investigational Phase 2,Not Applicable 671-16-9 4915
7
rituximab Approved Phase 2,Phase 1,Not Applicable 174722-31-7 10201696
8
Levoleucovorin Approved, Investigational Phase 2 68538-85-2
9
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
10
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
11
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
12
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2,Phase 1 59-30-3 6037
13
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
14
Doxil Approved June 1999 Phase 2 31703
15 Immunologic Factors Phase 2,Phase 1
16 Antimitotic Agents Phase 2
17 Antimetabolites, Antineoplastic Phase 2,Phase 1
18 Antiviral Agents Phase 2
19 Vitamin B Complex Phase 2,Phase 1
20 Folate Phase 2,Phase 1
21 Antirheumatic Agents Phase 2,Phase 1
22 Vitamin B9 Phase 2,Phase 1
23 Antineoplastic Agents, Alkylating Phase 2
24 Folic Acid Antagonists Phase 2,Phase 1
25 Immunosuppressive Agents Phase 2,Phase 1
26 Alkylating Agents Phase 2
27 Dermatologic Agents Phase 2,Phase 1
28 Anti-Infective Agents Phase 2
29 Nucleic Acid Synthesis Inhibitors Phase 2,Phase 1
30 Antimetabolites Phase 2,Phase 1
31 Antineoplastic Agents, Phytogenic Phase 2
32 Antineoplastic Agents, Immunological Phase 2,Phase 1
33 Calcium, Dietary Phase 2
34 Anti-Retroviral Agents Phase 2
35 Autonomic Agents Phase 2
36 Hormone Antagonists Phase 2
37 Anti-Bacterial Agents Phase 2
38 Peripheral Nervous System Agents Phase 2
39 Antiemetics Phase 2
40 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
41 Gastrointestinal Agents Phase 2
42 Antineoplastic Agents, Hormonal Phase 2
43 Hormones Phase 2
44 glucocorticoids Phase 2
45 Antibiotics, Antitubercular Phase 2
46 Topoisomerase Inhibitors Phase 2
47 BB 1101 Phase 2
48 Anti-Inflammatory Agents Phase 2
49
Pemetrexed Approved, Investigational Phase 1 150399-23-8, 137281-23-3 60843 446556

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Methotrexate and Temozolomide Versus Methotrexate, Procarbazine, Vincristine and Cytarabine Unknown status NCT00503594 Phase 2 Methotrexate and temozolomide;Methotrexate , procarbazine ,vincristine ,cytarabine
2 Phase II Study to Evaluate the Combination of Rituximab and DepoCyte® in the C5R Chemotherapy Protocol in Patients Between the Ages of 18 and 60 Years With Primary Cerebral Non-Hodgkin Lymphoma and Systemic Diffuse Large B-cell Lymphoma With Neuromeningeal Invasion at Diagnosis Completed NCT00553943 Phase 2 Rituximab;Cytarabine
3 Chemotherapy and HAART to Treat AIDS-related Primary Brain Lymphoma Recruiting NCT00267865 Phase 2 Methotrexate;Rituximab;Leucovorin
4 Copanlisib With Ibrutinib for Patients With Recurrent/ Refractory Primary Central Nervous System Lymphoma (PCNSL) Recruiting NCT03581942 Phase 1, Phase 2 Ibrutinib;Copanlisib
5 Phase II Study Evaluating a Combination of Pegylated Liposomal Doxorubicin and Dexamethasone for the Treatment of Immunocompetent Patients With Cerebral Lymphoma Relapsed or Refractory to First-line Chemotherapy With High Dose Methotrexate (MTXHD) and / or High-dose Cytarabine. Terminated NCT01848652 Phase 2 infusion of MYOCET
6 A Safety Study of Rituximab Plus MTX Injected Into the Cerebrospinal Fluid in the Treatment of Brain Lymphoma Completed NCT00221325 Phase 1 Intraventricular Rituximab Plus MTX
7 Treatment of Recurrent Primary or Secondary Central Nervous System (CNS) Lymphoma With ALIMTA (Pemetrexed) Completed NCT00916630 Phase 1 pemetrexed
8 Role of [18F]-FDG Brain PET in Newly Diagnosed Primary Cerebral Lymphoma, in Immunocompetent Patient Older Than 60 Years Recruiting NCT03582254 Not Applicable
9 SMOLY : Phenotype and Functions of Monocyte Subtypes in High Grade B Lymphoma: Towards New Biomarkers? Active, not recruiting NCT03672682
10 Lactate Imaging as a Tumour Biomarker Active, not recruiting NCT01881386
11 Integrated Discovery of New Immuno-Molecular Actionable Biomarkers for Tumors With Immune-suppressed Environment Not yet recruiting NCT03706625

Search NIH Clinical Center for Cerebral Lymphoma

Genetic Tests for Cerebral Lymphoma

Anatomical Context for Cerebral Lymphoma

MalaCards organs/tissues related to Cerebral Lymphoma:

42
Brain, Pituitary, B Cells, Thyroid, Monocytes, Kidney, Eye

Publications for Cerebral Lymphoma

Articles related to Cerebral Lymphoma:

(show top 50) (show all 121)
# Title Authors Year
1
Lenalidomide in Combination with Intravenous Rituximab (REVRI) in Relapsed/Refractory Primary CNS Lymphoma or Primary Intraocular Lymphoma: a Multicenter Prospective "Proof of Concept" Phase II Study of the French Oculo-Cerebral Lymphoma (LOC) Network and the Lymphoma Study Association (LYSA). ( 30698644 )
2019
2
Cerebral lymphoma presenting as a rhombencephalitis: Case report and review of the literature. ( 31030899 )
2019
3
Brain lesions in a long-term kidney transplant recipient: Primary cerebral lymphoma or cerebral toxoplasmosis? ( 26383060 )
2017
4
Differentiation between Glioblastoma Multiforme and Primary Cerebral Lymphoma: Additional Benefits of Quantitative Diffusion-Weighted MR Imaging. ( 27631626 )
2016
5
Cerebral Lymphoma in a Kidney Transplant: A Case Report. ( 26030159 )
2015
6
Fluorescein sodium-guided surgery in cerebral lymphoma. ( 26432995 )
2015
7
Non-invasive assessment of intratumoral vascularity using arterial spin labeling: A comparison to susceptibility-weighted imaging for the differentiation of primary cerebral lymphoma and glioblastoma. ( 24613549 )
2014
8
Chronic cough as a presenting feature of cerebral lymphoma. ( 25344556 )
2014
9
Differentiation between primary cerebral lymphoma and glioblastoma using the apparent diffusion coefficient: comparison of three different ROI methods. ( 25393543 )
2014
10
Primary cerebral lymphoma with spontaneous remission. ( 22037213 )
2013
11
Utility of FDG-PETCT and magnetic resonance spectroscopy in differentiating between cerebral lymphoma and non-malignant CNS lesions in HIV-infected patients. ( 23578921 )
2013
12
EBV related cerebral lymphoma in a leukemia patient treated with alemtuzumab. ( 21136270 )
2011
13
Imaging diagnosis-magnetic resonance imaging features of metastatic cerebral lymphoma in a dog. ( 21388473 )
2011
14
Does adding FDG-PET to MRI improve the differentiation between primary cerebral lymphoma and glioblastoma? Observer performance study. ( 21404136 )
2011
15
Fatal septicemia in a patient with cerebral lymphoma and an Amplatzer septal occluder: a case report. ( 22115504 )
2011
16
An atypical case of X-linked lymphoproliferative disease revealed as a late cerebral lymphoma. ( 19906447 )
2010
17
EBV-positive B cell cerebral lymphoma 12 years after sex-mismatched kidney transplantation: post-transplant lymphoproliferative disorder or donor-derived lymphoma? ( 20348150 )
2010
18
Therapeutic drug monitoring for busulfan in plasma during conditioning chemotherapy for autologous stem cell transplantation in relapsed primary cerebral lymphoma. ( 20386358 )
2010
19
Monoclonal gammopathy as a marker of primary cerebral lymphoma. ( 19453652 )
2009
20
Primary cerebral lymphoma with a 5-year remission to single-agent corticosteroids. ( 19637089 )
2009
21
Primary cerebral lymphoma and glioblastoma multiforme: differences in diffusion characteristics evaluated with diffusion tensor imaging. ( 18065516 )
2008
22
A spontaneously vanishing primary cerebral lymphoma "ghost tumour". ( 18796594 )
2008
23
Importance of functional MRI and the role of stereotactic biopsy in the diagnosis of cerebral lymphoma. ( 24256963 )
2008
24
Cerebral lymphoma: clinical and radiological findings in 90 cases. ( 17367223 )
2007
25
Contiguous synchronous occurrence of primary cerebral lymphoma and meningioma. ( 17453773 )
2007
26
Primary cerebral lymphoma: clinical and aeromedical considerations. ( 17484350 )
2007
27
Highly active antiretroviral therapy and human immunodeficiency virus-associated primary cerebral lymphoma. ( 16882946 )
2006
28
Intraocular lymphoma as a masquerade syndrome complicating cerebral lymphoma of the corpus callosum. ( 15558282 )
2005
29
Phenotypic APC resistance as a marker of hypercoagulability in primitive cerebral lymphoma. ( 15995637 )
2005
30
Atypical manifestation of childhood primary cerebral lymphoma restricted to the leptomeninges. ( 16044275 )
2005
31
Cerebral lymphoma in an adenosine deaminase-deficient patient with severe combined immunodeficiency receiving polyethylene glycol-conjugated adenosine deaminase. ( 16263974 )
2005
32
Side effects related to cancer treatment: CASE 3. Primary cerebral lymphoma after radiotherapy for recurrent meningioma. ( 16293883 )
2005
33
Changing pattern of primary cerebral lymphoma in the highly active antiretroviral therapy era. ( 16540454 )
2005
34
Primary cerebral lymphoma: a retrospective study in 22 immunocompetent patients. ( 15315308 )
2004
35
Clinical response following adjuvant Temozolomide in a patient with primary cerebral lymphoma. ( 15736462 )
2004
36
Distinguishing of primary cerebral lymphoma from high-grade glioma with perfusion-weighted magnetic resonance imaging. ( 12566167 )
2003
37
Primary cerebral lymphoma presenting as diffuse leukoencephalopathy. ( 12700473 )
2003
38
Reversible choreoathetosis in primary cerebral lymphoma: clinicoradiologic correlation. ( 12824713 )
2003
39
Diffusion-weighted imaging and single-voxel MR spectroscopy in a case of malignant cerebral lymphoma. ( 14605786 )
2003
40
Selective circadian rhythm disturbance in cerebral lymphoma. ( 14607354 )
2003
41
B cell non-Hodgkin cerebral lymphoma associated with an anaplastic oligodendroglioma. ( 12489671 )
2002
42
Primary cerebral lymphoma and membranous nephropathy: a still unreported association. ( 12046053 )
2002
43
Cerebral lymphoma presenting as a leukoencephalopathy. ( 11459903 )
2001
44
Central neurogenic hyperventilation with primary cerebral lymphoma: a case report. ( 11550722 )
2001
45
Acquired immunodeficiency syndrome-related primary cerebral lymphoma: response to irradiation. ( 10849981 )
2000
46
Giant anterior communicating artery aneurysm infiltrated with a primary cerebral lymphoma: case report. ( 10942022 )
2000
47
Acquired immunodeficiency syndrome-related primary cerebral lymphoma. ( 10194581 )
1999
48
Ocular and fulminant cerebral lymphoma in AIDS. ( 10454187 )
1999
49
Treatment outcome in presumed and confirmed AIDS-related primary cerebral lymphoma. ( 10492634 )
1999
50
HIV-related primary cerebral lymphoma: the role of stereotactic biopsy. ( 10835171 )
1999

Variations for Cerebral Lymphoma

Expression for Cerebral Lymphoma

Search GEO for disease gene expression data for Cerebral Lymphoma.

Pathways for Cerebral Lymphoma

GO Terms for Cerebral Lymphoma

Cellular components related to Cerebral Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.43 SLC19A1 SSTR1 SSTR2 SSTR3 SSTR5 SYNE1
2 integral component of plasma membrane GO:0005887 9.02 SLC19A1 SSTR1 SSTR2 SSTR3 SSTR5

Biological processes related to Cerebral Lymphoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.91 SST SSTR1 SSTR2 SSTR3 SSTR5
2 spermatogenesis GO:0007283 9.8 SSTR1 SSTR2 SSTR3 SYNE1
3 negative regulation of cell proliferation GO:0008285 9.72 SST SSTR1 SSTR2 SSTR3 SSTR5
4 forebrain development GO:0030900 9.63 SSTR1 SSTR2 SSTR3
5 cerebellum development GO:0021549 9.61 SSTR1 SSTR2 SSTR3
6 cellular response to estradiol stimulus GO:0071392 9.58 SSTR1 SSTR2 SSTR3
7 response to starvation GO:0042594 9.54 SSTR1 SSTR2 SSTR3
8 hormone-mediated apoptotic signaling pathway GO:0008628 9.48 SST SSTR3
9 neuropeptide signaling pathway GO:0007218 9.46 SSTR1 SSTR2 SSTR3 SSTR5
10 cellular response to glucocorticoid stimulus GO:0071385 9.43 SSTR2 SSTR3 SSTR5
11 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.26 SSTR1 SSTR2 SSTR3 SSTR5
12 somatostatin signaling pathway GO:0038170 8.92 SSTR1 SSTR2 SSTR3 SSTR5

Molecular functions related to Cerebral Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.46 SSTR1 SSTR2 SSTR3 SSTR5
2 neuropeptide binding GO:0042923 9.26 SSTR1 SSTR2 SSTR3 SSTR5
3 somatostatin receptor activity GO:0004994 8.92 SSTR1 SSTR2 SSTR3 SSTR5

Sources for Cerebral Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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