MCID: CRB001
MIFTS: 37

Cerebral Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases, Neuronal diseases

Aliases & Classifications for Cerebral Lymphoma

MalaCards integrated aliases for Cerebral Lymphoma:

Name: Cerebral Lymphoma 12 15
Primary Cerebral Lymphoma 12 70
Primary Lymphoma of Cerebrum 12
Brain Primary Lymphoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5815
NCIt 50 C7611
SNOMED-CT 67 276836002
UMLS 70 C0240803

Summaries for Cerebral Lymphoma

Disease Ontology : 12 A cerebrum cancer that affects the lymph cells and derives from the brain.

MalaCards based summary : Cerebral Lymphoma, also known as primary cerebral lymphoma, is related to reticulum cell sarcoma and diffuse large b-cell lymphoma. An important gene associated with Cerebral Lymphoma is SST (Somatostatin), and among its related pathways/superpathways are NF-kappaB Signaling and Cell adhesion molecules. The drugs Cytarabine and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and bone, and related phenotype is immune system.

Related Diseases for Cerebral Lymphoma

Diseases related to Cerebral Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 313)
# Related Disease Score Top Affiliating Genes
1 reticulum cell sarcoma 29.9 TNFRSF8 CD4
2 diffuse large b-cell lymphoma 29.6 TNFRSF8 MME CD79A CD19
3 membranous nephropathy 29.4 MME LRP2 CD79A
4 demyelinating disease 29.2 MAG CD8A CD4
5 immune deficiency disease 29.1 TNFRSF8 CD8A CD79A CD4
6 lymphoma, non-hodgkin, familial 29.0 TNFRSF8 MME CD8A CD79A CD4 CD19
7 peripheral t-cell lymphoma 28.7 TNFRSF8 MME CD8A CD19
8 primary central nervous system lymphoma 11.1
9 central nervous system lymphoma 10.4
10 angular cheilitis 10.4 SST CD4
11 acquired immunodeficiency syndrome 10.4
12 congenital syphilis 10.3 CD79A CD4
13 sporotrichosis 10.3 CD79A CD4
14 lobomycosis 10.3 CD4 CD19
15 monoclonal paraproteinemia 10.3 CD79A CD19
16 strongyloidiasis 10.3 CD79A CD4
17 mononeuritis of upper limb and mononeuritis multiplex 10.3 MAG CD4
18 mononeuritis multiplex 10.3 MAG CD4
19 alpha chain disease 10.2 CD79A CD19
20 autoimmune peripheral neuropathy 10.2 MAG CD4
21 aids phobia 10.2 MME CD4
22 american histoplasmosis 10.2 TNFRSF8 CD4
23 appendix lymphoma 10.2 SST MME
24 b-cell lymphoma 10.2
25 autoimmune neuropathy 10.2 MAG CD4
26 bladder lymphoma 10.2 MME CD79A
27 hilar lung carcinoma 10.2 MME CD79A
28 lung hilum cancer 10.2 MME CD79A
29 hodgkin's lymphoma, lymphocytic depletion 10.2 TNFRSF8 CD79A
30 cat-scratch disease 10.2 TNFRSF8 CD4
31 toxoplasmosis 10.2
32 epiglottis neoplasm 10.2 MME CD79A
33 liver lymphoma 10.2 MME CD79A
34 infected hydrocele 10.2 TNFRSF8 CD79A
35 mediastinal malignant lymphoma 10.2 TNFRSF8 CD79A
36 colon lymphoma 10.2 MME CD79A
37 hodgkin's lymphoma, nodular sclerosis 10.2 TNFRSF8 CD79A
38 mediastinal gray zone lymphoma 10.2 TNFRSF8 CD79A
39 bartonellosis 10.2 TNFRSF8 CD4
40 sclerosing hepatic carcinoma 10.2 MME CD79A
41 mite infestation 10.2 TNFRSF8 CD4
42 vaginal cancer 10.2 MME CD4
43 mononeuropathy 10.2 MAG CD4
44 polyclonal hypergammaglobulinemia 10.2 MME CD4
45 lymphoma, hodgkin, classic 10.2
46 lymphoma 10.2
47 breast osteosarcoma 10.2 MME CD79A
48 mediastinal cancer 10.2 TNFRSF8 CD79A
49 uveitis 10.2
50 central nervous system leukemia 10.2 MME CD19

Graphical network of the top 20 diseases related to Cerebral Lymphoma:



Diseases related to Cerebral Lymphoma

Symptoms & Phenotypes for Cerebral Lymphoma

MGI Mouse Phenotypes related to Cerebral Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 CD19 CD4 CD79A CD8A LRP2 MAG

Drugs & Therapeutics for Cerebral Lymphoma

Drugs for Cerebral Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
2
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
3
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
5
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
6 Anti-Infective Agents Phase 2
7 Antineoplastic Agents, Immunological Phase 2
8 Antirheumatic Agents Phase 2
9 Immunosuppressive Agents Phase 2
10 Immunologic Factors Phase 2
11 Antiviral Agents Phase 2
12 Antimetabolites Phase 2
13
Liposomal doxorubicin Phase 2 31703
14 Antibiotics, Antitubercular Phase 2
15 Anti-Bacterial Agents Phase 2
16
rituximab Approved 174722-31-7 10201696
17
Vincristine Approved, Investigational 2068-78-2, 57-22-7 5978
18
Procarbazine Approved, Investigational 671-16-9 4915

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective Multicentre Phase II Study to Evaluate the Combination of Rituximab and DepoCyte® by Intrathecal Injection in the C5R Chemotherapy Protocol in Patients Between the Ages of 18 and 60 Years With Primary Cerebral Non-Hodgkin Lymphoma and Systemic Diffuse Large B-cell Lymphoma With Neuromeningeal Invasion at Diagnosis Completed NCT00553943 Phase 2 Rituximab;Cytarabine
2 Phase II Study Evaluating the Combination Pegylated Liposomal Doxorubicin and Dexamethasone for the Treatment of Immunocompetent Patients With Cerebral Lymphoma Relapsed or Refractory to First-line Chemotherapy Containing High Dose Methotrexate (MTXHD) and / or High-dose Cytarabine. Terminated NCT01848652 Phase 2 infusion of MYOCET
3 Role of [18F]-FDG Brain PET in Newly Diagnosed Primary Cerebral Lymphoma, in Immunocompetent Patient Older Than 60 Years Recruiting NCT03582254

Search NIH Clinical Center for Cerebral Lymphoma

Genetic Tests for Cerebral Lymphoma

Anatomical Context for Cerebral Lymphoma

MalaCards organs/tissues related to Cerebral Lymphoma:

40
Brain, Lung, Bone, Colon, Heart, Breast, Skin

Publications for Cerebral Lymphoma

Articles related to Cerebral Lymphoma:

(show top 50) (show all 358)
# Title Authors PMID Year
1
Incidental Finding of a Large Right Atrial Thrombus in a Patient With Cerebral Lymphoma. 61
33749363 2021
2
Classification of Primary Cerebral Lymphoma and Glioblastoma Featuring Dynamic Susceptibility Contrast and Apparent Diffusion Coefficient. 61
33233698 2020
3
Differentiating glioblastoma multiforme from cerebral lymphoma: application of advanced texture analysis of quantitative apparent diffusion coefficients. 61
32628089 2020
4
Primary cerebral lymphoma' characteristics, incidence, survival, and causes of death in the United States. 61
32428760 2020
5
Analysis of soluble interleukin-2 receptor as CSF biomarker for neurosarcoidosis. 61
32393650 2020
6
Pearls and Pitfalls in Interpretation of 68Ga-DOTATOC PET Imaging. 61
32332303 2020
7
Management and outcome of primary CNS lymphoma in the modern era: An LOC network study. 61
31907289 2020
8
CAR T-Cell Therapy Is Effective but Not Long-Lasting in B-Cell Lymphoma of the Brain. 61
32903866 2020
9
Effect of Brivaracetam on Efficacy and Tolerability in Patients With Brain Tumor-Related Epilepsy: A Retrospective Multicenter Study. 61
32973649 2020
10
13N-NH3 PET/CT in oncological disease. 61
31599383 2019
11
Developing infrared spectroscopic detection for stratifying brain tumour patients: glioblastoma multiforme vs. lymphoma. 61
31612875 2019
12
Ibrutinib monotherapy for relapse or refractory primary CNS lymphoma and primary vitreoretinal lymphoma: Final analysis of the phase II 'proof-of-concept' iLOC study by the Lymphoma study association (LYSA) and the French oculo-cerebral lymphoma (LOC) network. 61
31279304 2019
13
Cerebral lymphoma presenting as a rhombencephalitis: Case report and review of the literature. 61
31030899 2019
14
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†. 61
30698644 2019
15
Post-transplant lymphoproliferative disease may be an adverse risk factor for patient survival but not graft loss in kidney transplant recipients. 61
30173897 2018
16
Presentation, etiology, and outcome of brain infections in an Indonesian hospital: A cohort study. 61
30564491 2018
17
[Presentation of a case of primary cerebral lymphoma diagnosed in an immunocompetent patient during a dementia study]. 61
29496301 2018
18
Associations between apparent diffusion coefficient (ADC) and KI 67 in different tumors: a meta-analysis. Part 2: ADCmin. 61
29492226 2018
19
[Central Neurological Diagnosis in Patients Infected with HIV in the Infectious Diseases Unit of University Hospital of Casablanca, Morocco]. 61
30763499 2018
20
Associations between apparent diffusion coefficient (ADC) and KI 67 in different tumors: a meta-analysis. Part 1: ADCmean. 61
29088879 2017
21
Differentiating enhancing multiple sclerosis lesions, glioblastoma, and lymphoma with dynamic texture parameters analysis (DTPA): A feasibility study. 61
28543071 2017
22
Brain lesions in a long-term kidney transplant recipient: Primary cerebral lymphoma or cerebral toxoplasmosis? 61
26383060 2017
23
Toxoplasmosis versus lymphoma: Cerebral lesion characterization using DSC-MRI revisited. 61
27940418 2017
24
Differentiation between Glioblastoma Multiforme and Primary Cerebral Lymphoma: Additional Benefits of Quantitative Diffusion-Weighted MR Imaging. 61
27631626 2016
25
Diagnosing HIV-associated cerebral diseases - the importance of Neuropathology in understanding HIV. 61
27833967 2016
26
Fluorescein sodium-guided surgery in cerebral lymphoma. 61
26432995 2015
27
Cerebral Lymphoma in a Kidney Transplant: A Case Report. 61
26030159 2015
28
Outcomes after intensive care unit admission of patients with newly diagnosed lymphoma. 61
25098426 2015
29
[Cerebral lymphoma: a classic presentation?]. 61
25854049 2015
30
Evaluation of regional cerebral glucose metabolism in patients with malignant lymphoma of the body using statistical image analysis. 61
25113148 2014
31
Chronic cough as a presenting feature of cerebral lymphoma. 61
25344556 2014
32
A case of delayed methotrexate clearance following administration of a complementary medication containing chlorophyll. 61
23824495 2014
33
Non-invasive assessment of intratumoral vascularity using arterial spin labeling: A comparison to susceptibility-weighted imaging for the differentiation of primary cerebral lymphoma and glioblastoma. 61
24613549 2014
34
A rare presentation of atypical demyelination: tumefactive multiple sclerosis causing Gerstmann's syndrome. 61
24694183 2014
35
Diagnosis of primary cerebral lymphomas: possible value of PCR testing in equivocal cases requiring rebiopsy. 61
23875881 2014
36
Primary extranodal non-Hodgkin's lymphoma: clinicopathological features, survival and treatment outcome in two cancer centers of southern Turkey. 61
25227815 2014
37
Differentiation between primary cerebral lymphoma and glioblastoma using the apparent diffusion coefficient: comparison of three different ROI methods. 61
25393543 2014
38
Treatment of immigrants and residents suffering from neuro-AIDS on a neurological intensive care unit: epidemiology and predictors of outcome. 61
23460392 2013
39
[Cognitive evaluation during brain radiotherapy in adults: a simple assessment is possible]. 61
24007953 2013
40
Difficulties with diagnosis and consequential poor outcome due to stigma of acquired immunodeficiency syndrome - a case report. 61
24091082 2013
41
Utility of FDG-PETCT and magnetic resonance spectroscopy in differentiating between cerebral lymphoma and non-malignant CNS lesions in HIV-infected patients. 61
23578921 2013
42
Preclinical study of Ublituximab, a Glycoengineered anti-human CD20 antibody, in murine models of primary cerebral and intraocular B-cell lymphomas. 61
23611989 2013
43
Lymphoma B-cell responsiveness to CpG-DNA depends on the tumor microenvironment. 61
23561041 2013
44
Primary cerebral lymphoma with spontaneous remission. 61
22037213 2013
45
A case of oculo-cerebral B-cell lymphoma in a cat. 61
22520020 2013
46
Brain tumors. 61
23026359 2012
47
[Primary cerebral lymphoma]. 61
23096518 2012
48
[Causes of death among 91 HIV-infected adults in the era of potent antiretroviral therapy]. 61
22350063 2012
49
Primary central nervous system lymphoma masquerading as bilateral vitreous floaters. 61
22498134 2012
50
Fatal septicemia in a patient with cerebral lymphoma and an Amplatzer septal occluder: a case report. 61
22115504 2011

Variations for Cerebral Lymphoma

Expression for Cerebral Lymphoma

Search GEO for disease gene expression data for Cerebral Lymphoma.

Pathways for Cerebral Lymphoma

GO Terms for Cerebral Lymphoma

Cellular components related to Cerebral Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.35 LRP2 CD8A CD79A CD4 CD19
2 membrane raft GO:0045121 9.02 MME MAG CD79A CD4 CD19

Biological processes related to Cerebral Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.46 CD8A CD79A CD4 CD19
2 amyloid-beta clearance GO:0097242 8.96 MME LRP2
3 cell surface receptor signaling pathway GO:0007166 8.92 SST CD8A CD79A CD4

Sources for Cerebral Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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