MCID: CRB036
MIFTS: 35

Cerebral Meningioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Cerebral Meningioma

MalaCards integrated aliases for Cerebral Meningioma:

Name: Cerebral Meningioma 12 54 15 70
Meningioma of Cerebrum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6112
NCIt 50 C4807
SNOMED-CT 67 189164002
UMLS 70 C0542564

Summaries for Cerebral Meningioma

MalaCards based summary : Cerebral Meningioma, also known as meningioma of cerebrum, is related to brain meningioma and meningioma, familial, and has symptoms including seizures and headache. An important gene associated with Cerebral Meningioma is DRD1 (Dopamine Receptor D1), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. Affiliated tissues include lung, thyroid and skin, and related phenotypes are Increased HDAC inhibitor resistance and behavior/neurological

Related Diseases for Cerebral Meningioma

Diseases related to Cerebral Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 brain meningioma 29.9 PGR LIFR
2 meningioma, familial 10.6
3 intracranial meningioma 10.6
4 secretory meningioma 10.6
5 lymphoplasmacyte-rich meningioma 10.6
6 calcifying aponeurotic fibroma 10.2 PGR EGF
7 sodoku disease 10.2 OSM LIF
8 mixed cell adenoma 10.1 IGF1 EGF
9 donohue syndrome 10.1 IGF1 EGF
10 diffuse idiopathic skeletal hyperostosis 10.1 IGF1 EGF
11 osteochondrosis 10.1 OSM IGF1
12 prostatic hypertrophy 10.1 PGR EGF
13 null-cell leukemia 10.0 LIF IL6
14 chronic ulcer of skin 10.0 IL6 EGF
15 stachybotrys chartarum 10.0 LIF IL6
16 trachoma 10.0 IL6 EGF
17 autoimmune gastritis 10.0 IL6 EGF
18 human herpesvirus 8 10.0 IL6R IL6
19 opiate dependence 10.0 IGF1 DRD1
20 arthrogryposis, distal, type 1a 10.0 OSM LIFR LIF
21 perinatal necrotizing enterocolitis 10.0 IL6 EGF
22 traumatic brain injury 10.0 IL6 IGF1
23 brain injury 10.0 IL6 IGF1
24 vaginal discharge 10.0 PGR IL6
25 decubitus ulcer 10.0 IL6 IGF1
26 nerve compression syndrome 9.9 IL6 IGF1
27 thyroid cancer, nonmedullary, 1 9.9
28 parkinsonism 9.9
29 adenoma 9.9
30 parathyroid adenoma 9.9
31 thyroid carcinoma 9.9
32 chickenpox 9.9 PGR IL6
33 endometritis 9.9 PGR IL6
34 galactorrhea 9.9 PRLR IGF1
35 lipid-rich breast carcinoma 9.9 PRLR PGR
36 estrogen-receptor negative breast cancer 9.9 PGR IGF1 EGF
37 endometrial adenocarcinoma 9.9 PGR IGF1 EGF
38 breast adenoma 9.9 PRLR PGR
39 lipid-rich carcinoma 9.9 PRLR PGR
40 ischemic bone disease 9.9 IL6 IGF1
41 short syndrome 9.9 PGR IL6
42 apnea, obstructive sleep 9.8 IL6 IGF1
43 short bowel syndrome 9.8 IL6 IGF1 EGF
44 lobular neoplasia 9.8 PRLR PGR
45 lipomatosis, multiple 9.8
46 migraine with or without aura 1 9.8
47 parkinson disease, late-onset 9.8
48 ataxia and polyneuropathy, adult-onset 9.8
49 anorexia nervosa 9.8
50 gastrointestinal ulceration, recurrent, with dysfunctional platelets 9.8

Graphical network of the top 20 diseases related to Cerebral Meningioma:



Diseases related to Cerebral Meningioma

Symptoms & Phenotypes for Cerebral Meningioma

UMLS symptoms related to Cerebral Meningioma:


seizures; headache

GenomeRNAi Phenotypes related to Cerebral Meningioma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased HDAC inhibitor resistance GR00115-A-0 8.62 LIF LIFR

MGI Mouse Phenotypes related to Cerebral Meningioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 DRD1 IL6 IL6R LIF LIFR OSM
2 homeostasis/metabolism MP:0005376 10.02 DRD1 IGF1 IL6 IL6R LIF LIFR
3 endocrine/exocrine gland MP:0005379 10.01 EGF IGF1 IL6 IL6R LIF LIFR
4 adipose tissue MP:0005375 9.93 DRD1 IGF1 IL6 IL6R LIF PRLR
5 immune system MP:0005387 9.92 DRD1 EGF IGF1 IL6 IL6R LIF
6 integument MP:0010771 9.86 DRD1 EGF IGF1 IL6 LIF OSM
7 nervous system MP:0003631 9.56 DRD1 IGF1 IL6 IL6R LIF LIFR
8 neoplasm MP:0002006 9.55 IGF1 IL6 IL6R PGR PRLR
9 reproductive system MP:0005389 9.17 EGF IGF1 IL6 LIF LIFR PGR

Drugs & Therapeutics for Cerebral Meningioma

Search Clinical Trials , NIH Clinical Center for Cerebral Meningioma

Genetic Tests for Cerebral Meningioma

Anatomical Context for Cerebral Meningioma

MalaCards organs/tissues related to Cerebral Meningioma:

40
Lung, Thyroid, Skin, Lymph Node, Breast, Cervix

Publications for Cerebral Meningioma

Articles related to Cerebral Meningioma:

(show top 50) (show all 59)
# Title Authors PMID Year
1
[Estrogen and progesterone receptors in cerebral meningioma and their clinical value]. 61 54
12378940 2002
2
Inhibition of proliferation of human cerebral meningioma cells by suramin: effects on cell growth, cell cycle phases, extracellular growth factors, and PDGF-BB autocrine growth loop. 61 54
7897522 1995
3
Presence of dopamine D1 receptors and absence of dopamine D2 receptors in human cerebral meningioma tissue. 61 54
1385626 1992
4
Altered Cerebrospinal Fluid (CSF) in Children with Ataxia Telangiectasia. 61
32815118 2021
5
A Secretory Variant of Cerebral Meningioma with Partial Spontaneous Regression in a Cow. 61
33222879 2020
6
Clinical and Etiological Characteristics of Epilepsy in the Elderly: A Hospital-Based Study from a Tertiary Care Referral Center of Niamey, Niger. 61
31831973 2019
7
Participation restrictions in patients after surgery for cerebral meningioma. 61
30264851 2018
8
Periocular manifestations of trigeminal trophic syndrome: A case series and literature review. 61
28812959 2018
9
MR diffusion kurtosis imaging predicts malignant potential and the histological type of meningioma. 61
28987682 2017
10
Uncommon association of cerebral meningioma, parathyroid adenoma and papillary thyroid carcinoma in a patient harbouring a rare germline variant in the CDKN1B gene. 61
26762354 2016
11
Uptake and tracer kinetics of O-(2-(18)F-fluoroethyl)-L-tyrosine in meningiomas: preliminary results. 61
25331459 2015
12
Cognitive and emotional problems in patients after cerebral meningioma surgery. 61
24763925 2014
13
Cerebral meningioma presenting as dystonic head tremor. 61
24259285 2014
14
Unexpected finding of cerebral meningioma on (11)C-PiB PET. 61
23429388 2013
15
Patterns in neurosurgical adverse events: intracranial neoplasm surgery. 61
23116096 2012
16
An incidental finding of cerebral meningioma on 99mTc-TRODAT-1 dopamine transporter SPECT/CT. 61
22889784 2012
17
Unexpected finding on I-123 FP-CIT SPECT leading to the diagnosis of cerebral meningioma. 61
21220989 2011
18
A pregnant female with a large intracranial mass: Reviewing the evidence to obtain management guidelines for intracranial meningiomas during pregnancy. 61
21245945 2010
19
[Frontal pneumosinus dilatans associated with multiple cerebral meningioma]. 61
18313639 2008
20
"Benign" metastatic meningioma: clinico-pathological analysis of one case metastasising to the lung and overview on the concepts of either primitive or metastatic meningiomas of the lung. 61
17431673 2007
21
Neuroparalytic keratopathy as the first sign of a cerebral meningioma. 61
17894293 2007
22
An unusual association of cerebral meningioma, parathyroid adenoma and thyroid papillary carcinoma. 61
16724700 2006
23
[The diagnosis of cerebral meningiomas at the stage of early clinical manifestation]. 61
17117669 2006
24
[Quadruple sectoranopia]. 61
16395210 2005
25
Can the calcitonin used for a shoulder-hand syndrome have a role in the revelation of a cerebral meningioma? 61
15589451 2004
26
Radiotherapy after surgery for benign cerebral meningioma. 61
15066300 2004
27
Meningioma: is there an association with human leukocyte antigens? 61
14693734 2003
28
Acromegaly due to GHRH-secreting large bronchial carcinoid. Complete recovery following tumor surgery. 61
12058343 2002
29
Radiation-induced skin ulcer, cerebral meningioma, and skin cancer following radiation and radium treatment for actinomycosis. 61
11994636 2002
30
"Anorexia saved my life": coincidental anorexia nervosa and cerebral meningioma. 61
11746295 2001
31
Post-operative computed tomography in two dogs with cerebral meningioma. 61
11052366 2000
32
Formation of autocrine loops in human cerebral meningioma tissue by leukemia inhibitor factor, interleukin-6, and oncostatin M: inhibition of meningioma cell growth in vitro by recombinant oncostatin M. 61
9488310 1998
33
[A case of digestive epilepsy with late diagnosis: a disease not to be disregarded]. 61
9762197 1998
34
Aspiration biopsy cytology of pleuro-pulmonary metastasis from a recurrent meningioma. 61
21590214 1997
35
Prolactin receptors in human meningiomas: characterization and biological role. 61
9203990 1997
36
Dopamine D1, dopamine D2, and prolactin receptor messenger ribonucleic acid expression by the polymerase chain reaction in human meningiomas. 54
8869066 1996
37
Results of craniotomy for the treatment of cerebral meningioma in 42 cats. 61
8191679 1994
38
[Diagnosis of cerebral meningioma before hospitalization]. 61
7785249 1994
39
Metastasis of breast carcinoma to intracranial meningioma. Case report. 61
7838405 1994
40
Wound infection with meningitis caused by Salmonella typhimurium. 61
8338654 1993
41
[2 cases of coexistence of meningioma and glioma]. 61
1660111 1991
42
[Intracranial hemorrhages in cerebral meningioma]. 61
1664596 1991
43
Treatment of intracranial meningiomas in patients over 70 years old. 61
2096608 1990
44
Conjunctival flap-cosmetic shell-ptosis procedure. Treatment of blepharoptosis in severe keratopathy. 61
2597074 1989
45
[Anatomo-clinical conference. Hôpital Cochin. Case No. 3-1989. Cerebral meningioma and adrenal mass in a 70-year-old woman]. 61
2782771 1989
46
[Migraine and epilepsy in cerebral meningioma]. 61
3129348 1988
47
Neurosurgical, obstetric and endocrine aspects of meningioma during pregnancy. 61
3319945 1987
48
[Cerebral meningioma associated with thrombocytosis]. 61
2952986 1987
49
[Febrile cerebral arterial accident disclosing myxoma of the left atrium. Association with cerebral meningioma and lipoma]. 61
6239258 1984
50
Radiation-induced cerebral meningioma: a recognizable entity. 61
6593438 1984

Variations for Cerebral Meningioma

Expression for Cerebral Meningioma

Search GEO for disease gene expression data for Cerebral Meningioma.

Pathways for Cerebral Meningioma

Pathways related to Cerebral Meningioma according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 OSM LIFR LIF IL6R IL6 IGF1
2
Show member pathways
13.47 PRLR OSM LIFR LIF IL6R IL6
3
Show member pathways
13.31 PRLR LIFR IL6R IL6 IGF1 EGF
4
Show member pathways
13.19 OSM LIFR LIF IL6R IL6 IGF1
5
Show member pathways
13.11 PRLR OSM LIFR LIF IL6R IL6
6
Show member pathways
12.98 OSM LIFR LIF IL6R IL6 IGF1
7
Show member pathways
12.72 PRLR OSM IL6R IL6 IGF1 EGF
8
Show member pathways
12.68 LIFR LIF IL6 IGF1
9 12.66 IL6R IL6 IGF1 EGF
10
Show member pathways
12.43 IL6R IL6 IGF1 EGF
11
Show member pathways
12.21 LIFR IL6 IGF1 EGF
12
Show member pathways
12.16 IGF1 EGF DRD1
13
Show member pathways
12.15 IL6R IL6 IGF1 EGF
14 12.03 IL6R IL6 EGF
15
Show member pathways
12.01 LIF IGF1 EGF
16 11.94 LIFR LIF IGF1
17 11.94 LIF IL6 IGF1 EGF
18
Show member pathways
11.92 IL6 IGF1 EGF
19 11.84 OSM LIF IL6R IL6
20
Show member pathways
11.8 PRLR PGR EGF
21 11.79 IL6R IL6 IGF1
22 11.77 IL6R IL6 IGF1 EGF
23 11.72 IL6 IGF1 EGF
24
Show member pathways
11.57 PRLR OSM LIFR LIF IL6R IL6
25 11.55 PRLR OSM LIFR LIF IL6 IGF1
26 11.54 LIFR IL6 IGF1 EGF
27 11.51 IL6 IGF1 EGF
28
Show member pathways
11.32 OSM LIFR LIF IL6R IL6
29
Show member pathways
11.29 IL6R IL6
30 11.24 IL6R IL6 IGF1 EGF
31 11.2 LIF IL6
32 11.18 IL6R IL6
33 11.16 PRLR PGR
34
Show member pathways
11.06 IGF1 EGF
35 10.9 OSM LIFR
36 10.7 OSM LIFR LIF IL6 IGF1 EGF

GO Terms for Cerebral Meningioma

Cellular components related to Cerebral Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 OSM LIF IL6R IL6 IGF1 EGF
2 receptor complex GO:0043235 9.43 PRLR LIFR IL6R
3 extracellular region GO:0005576 9.23 PRLR OSM LIFR LIF IL6R IL6
4 interleukin-6 receptor complex GO:0005896 8.96 IL6R IL6

Biological processes related to Cerebral Meningioma according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.02 PGR OSM LIF IL6 IGF1
2 positive regulation of gene expression GO:0010628 9.85 LIF IL6 IGF1 EGF DRD1
3 positive regulation of cell migration GO:0030335 9.84 IGF1 EGF DRD1
4 cytokine-mediated signaling pathway GO:0019221 9.8 PRLR OSM LIFR LIF IL6R IL6
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.73 OSM IGF1 EGF
6 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.72 OSM LIF IL6
7 positive regulation of osteoblast differentiation GO:0045669 9.69 IL6R IL6 IGF1
8 positive regulation of chemokine production GO:0032722 9.66 IL6R IL6
9 acute-phase response GO:0006953 9.65 IL6R IL6
10 embryo implantation GO:0007566 9.65 PRLR LIF
11 lung alveolus development GO:0048286 9.65 PGR LIF
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.65 IL6R IL6 IGF1
13 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 OSM LIF IL6R IL6 IGF1
14 ERK1 and ERK2 cascade GO:0070371 9.64 IGF1 EGF
15 positive regulation of DNA binding GO:0043388 9.64 IGF1 EGF
16 positive regulation of mitotic nuclear division GO:0045840 9.63 IGF1 EGF
17 endocrine pancreas development GO:0031018 9.63 IL6R IL6
18 positive regulation of MAPK cascade GO:0043410 9.63 OSM LIF IL6R IL6 IGF1 EGF
19 interleukin-6-mediated signaling pathway GO:0070102 9.62 IL6R IL6
20 negative regulation of collagen biosynthetic process GO:0032966 9.61 IL6R IL6
21 positive regulation of interleukin-17 production GO:0032740 9.61 OSM IL6
22 positive regulation of leukocyte chemotaxis GO:0002690 9.6 IL6R IL6
23 positive regulation of acute inflammatory response GO:0002675 9.59 OSM IL6
24 activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 9.58 PRLR EGF
25 negative regulation of hormone secretion GO:0046888 9.58 OSM LIF
26 leukemia inhibitory factor signaling pathway GO:0048861 9.58 PRLR LIFR LIF
27 neutrophil mediated immunity GO:0002446 9.57 IL6R IL6
28 positive regulation of cell proliferation GO:0008284 9.56 PRLR OSM LIFR LIF IL6R IL6
29 T-helper 17 cell lineage commitment GO:0072540 9.54 IL6R IL6
30 oncostatin-M-mediated signaling pathway GO:0038165 9.54 PRLR OSM LIFR
31 vascular endothelial growth factor production GO:0010573 9.52 IL6R IL6
32 ciliary neurotrophic factor-mediated signaling pathway GO:0070120 9.49 LIFR IL6R
33 hepatic immune response GO:0002384 9.43 IL6R IL6
34 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.1 OSM LIF IL6R IL6 IGF1 EGF

Molecular functions related to Cerebral Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.63 OSM LIF IL6
2 ciliary neurotrophic factor receptor binding GO:0005127 9.43 PRLR LIFR
3 interleukin-6 receptor binding GO:0005138 9.4 IL6R IL6
4 oncostatin-M receptor activity GO:0004924 9.37 PRLR LIFR
5 cytokine receptor activity GO:0004896 9.33 PRLR LIFR IL6R
6 leukemia inhibitory factor receptor activity GO:0004923 9.32 PRLR LIFR
7 ciliary neurotrophic factor receptor activity GO:0004897 9.26 LIFR IL6R
8 cytokine binding GO:0019955 9.13 PRLR LIFR IL6R
9 growth factor activity GO:0008083 9.02 OSM LIF IL6 IGF1 EGF

Sources for Cerebral Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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