MCID: CRB036
MIFTS: 34

Cerebral Meningioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Cerebral Meningioma

MalaCards integrated aliases for Cerebral Meningioma:

Name: Cerebral Meningioma 12 54 15 71
Meningioma of Cerebrum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6112
NCIt 49 C4807
SNOMED-CT 67 189164002
UMLS 71 C0542564

Summaries for Cerebral Meningioma

MalaCards based summary : Cerebral Meningioma, also known as meningioma of cerebrum, is related to spinal meningioma and meningioma, radiation-induced, and has symptoms including seizures and headache. An important gene associated with Cerebral Meningioma is DRD1 (Dopamine Receptor D1), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. Affiliated tissues include lung, thyroid and skin, and related phenotypes are Increased HDAC inhibitor resistance and endocrine/exocrine gland

Related Diseases for Cerebral Meningioma

Diseases related to Cerebral Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 spinal meningioma 30.5 PGR NF2
2 meningioma, radiation-induced 30.4 PGR NF2
3 meningioma, familial 29.8 PGR NF2 IGF1
4 galactorrhea 29.6 PRLR IGF1
5 benign meningioma 29.4 PGR NF2
6 secretory meningioma 10.6
7 lymphoplasmacyte-rich meningioma 10.6
8 mixed cell adenoma 10.2 IGF1 EGF
9 sodoku disease 10.1 OSM LIF
10 donohue syndrome 10.1 IGF1 EGF
11 osteochondrosis 10.0 OSM IGF1
12 opiate dependence 10.0 IGF1 DRD1
13 breast cyst 10.0 IGF1 EGF
14 calcifying aponeurotic fibroma 9.9 PGR EGF
15 thyroid cancer, nonmedullary, 1 9.9
16 epilepsy 9.9
17 tinea capitis 9.9
18 adenoma 9.9
19 parathyroid adenoma 9.9
20 dermatophytosis 9.9
21 thyroid carcinoma 9.9
22 arthrogryposis, distal, type 1a 9.9 OSM LIFR LIF
23 plasmacytoma 9.9 OSM LIF IL6R
24 prostatic hypertrophy 9.8 PGR EGF
25 functioning pituitary adenoma 9.8 PRLR IGF1
26 lung meningioma 9.8 PGR NF2
27 mammographic density 9.8 PGR IGF1
28 polyp of corpus uteri 9.8 PGR NF2
29 lipomatosis, multiple 9.8
30 migraine with or without aura 1 9.8
31 parkinson disease, late-onset 9.8
32 anorexia nervosa 9.8
33 hyperprolactinemia 9.8
34 gastrointestinal ulceration, recurrent, with dysfunctional platelets 9.8
35 multinodular goiter 9.8
36 brain meningioma 9.8
37 pleomorphic lipoma 9.8
38 cholesteatoma of middle ear 9.8
39 goiter 9.8
40 leukemia 9.8
41 typhoid fever 9.8
42 amenorrhea 9.8
43 thrombocytosis 9.8
44 keratopathy 9.8
45 acute kidney failure 9.8
46 astrocytoma 9.8
47 papillary carcinoma 9.8
48 multiple endocrine neoplasia 9.8
49 skin carcinoma 9.8
50 cavernous sinus meningioma 9.8

Graphical network of the top 20 diseases related to Cerebral Meningioma:



Diseases related to Cerebral Meningioma

Symptoms & Phenotypes for Cerebral Meningioma

UMLS symptoms related to Cerebral Meningioma:


seizures, headache

GenomeRNAi Phenotypes related to Cerebral Meningioma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased HDAC inhibitor resistance GR00115-A-0 8.62 LIF LIFR

MGI Mouse Phenotypes related to Cerebral Meningioma:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.08 EGF IGF1 IL6R LIF LIFR NF2
2 growth/size/body region MP:0005378 10.06 DRD1 EGF IGF1 IL6R LIF LIFR
3 homeostasis/metabolism MP:0005376 10.06 DRD1 IGF1 IL6R LIF LIFR NF2
4 immune system MP:0005387 10.02 DRD1 EGF IGF1 IL6R LIF LIFR
5 hematopoietic system MP:0005397 9.98 DRD1 IGF1 IL6R LIF LIFR OSM
6 integument MP:0010771 9.92 DRD1 EGF IGF1 LIF NF2 OSM
7 adipose tissue MP:0005375 9.89 DRD1 IGF1 IL6R LIF PRLR
8 nervous system MP:0003631 9.76 DRD1 IGF1 IL6R LIF LIFR NF2
9 neoplasm MP:0002006 9.65 IGF1 IL6R NF2 PGR PRLR
10 reproductive system MP:0005389 9.5 EGF IGF1 LIF LIFR NF2 PGR
11 skeleton MP:0005390 9.1 IGF1 LIF LIFR NF2 PGR PRLR

Drugs & Therapeutics for Cerebral Meningioma

Search Clinical Trials , NIH Clinical Center for Cerebral Meningioma

Genetic Tests for Cerebral Meningioma

Anatomical Context for Cerebral Meningioma

MalaCards organs/tissues related to Cerebral Meningioma:

40
Lung, Thyroid, Skin, Lymph Node, Breast, Cervix

Publications for Cerebral Meningioma

Articles related to Cerebral Meningioma:

(show top 50) (show all 57)
# Title Authors PMID Year
1
[Estrogen and progesterone receptors in cerebral meningioma and their clinical value]. 61 54
12378940 2002
2
Inhibition of proliferation of human cerebral meningioma cells by suramin: effects on cell growth, cell cycle phases, extracellular growth factors, and PDGF-BB autocrine growth loop. 61 54
7897522 1995
3
Presence of dopamine D1 receptors and absence of dopamine D2 receptors in human cerebral meningioma tissue. 61 54
1385626 1992
4
Clinical and Etiological Characteristics of Epilepsy in the Elderly: A Hospital-Based Study from a Tertiary Care Referral Center of Niamey, Niger. 61
31831973 2019
5
Participation restrictions in patients after surgery for cerebral meningioma. 61
30264851 2018
6
Periocular manifestations of trigeminal trophic syndrome: A case series and literature review. 61
28812959 2018
7
MR diffusion kurtosis imaging predicts malignant potential and the histological type of meningioma. 61
28987682 2017
8
Uncommon association of cerebral meningioma, parathyroid adenoma and papillary thyroid carcinoma in a patient harbouring a rare germline variant in the CDKN1B gene. 61
26762354 2016
9
Uptake and tracer kinetics of O-(2-(18)F-fluoroethyl)-L-tyrosine in meningiomas: preliminary results. 61
25331459 2015
10
Cognitive and emotional problems in patients after cerebral meningioma surgery. 61
24763925 2014
11
Cerebral meningioma presenting as dystonic head tremor. 61
24259285 2014
12
Unexpected finding of cerebral meningioma on (11)C-PiB PET. 61
23429388 2013
13
Patterns in neurosurgical adverse events: intracranial neoplasm surgery. 61
23116096 2012
14
An incidental finding of cerebral meningioma on 99mTc-TRODAT-1 dopamine transporter SPECT/CT. 61
22889784 2012
15
Unexpected finding on I-123 FP-CIT SPECT leading to the diagnosis of cerebral meningioma. 61
21220989 2011
16
A pregnant female with a large intracranial mass: Reviewing the evidence to obtain management guidelines for intracranial meningiomas during pregnancy. 61
21245945 2010
17
[Frontal pneumosinus dilatans associated with multiple cerebral meningioma]. 61
18313639 2008
18
"Benign" metastatic meningioma: clinico-pathological analysis of one case metastasising to the lung and overview on the concepts of either primitive or metastatic meningiomas of the lung. 61
17431673 2007
19
Neuroparalytic keratopathy as the first sign of a cerebral meningioma. 61
17894293 2007
20
An unusual association of cerebral meningioma, parathyroid adenoma and thyroid papillary carcinoma. 61
16724700 2006
21
[The diagnosis of cerebral meningiomas at the stage of early clinical manifestation]. 61
17117669 2006
22
[Quadruple sectoranopia]. 61
16395210 2005
23
Can the calcitonin used for a shoulder-hand syndrome have a role in the revelation of a cerebral meningioma? 61
15589451 2004
24
Radiotherapy after surgery for benign cerebral meningioma. 61
15066300 2004
25
Meningioma: is there an association with human leukocyte antigens? 61
14693734 2003
26
Acromegaly due to GHRH-secreting large bronchial carcinoid. Complete recovery following tumor surgery. 61
12058343 2002
27
Radiation-induced skin ulcer, cerebral meningioma, and skin cancer following radiation and radium treatment for actinomycosis. 61
11994636 2002
28
"Anorexia saved my life": coincidental anorexia nervosa and cerebral meningioma. 61
11746295 2001
29
Post-operative computed tomography in two dogs with cerebral meningioma. 61
11052366 2000
30
Formation of autocrine loops in human cerebral meningioma tissue by leukemia inhibitor factor, interleukin-6, and oncostatin M: inhibition of meningioma cell growth in vitro by recombinant oncostatin M. 61
9488310 1998
31
[A case of digestive epilepsy with late diagnosis: a disease not to be disregarded]. 61
9762197 1998
32
Aspiration biopsy cytology of pleuro-pulmonary metastasis from a recurrent meningioma. 61
21590214 1997
33
Prolactin receptors in human meningiomas: characterization and biological role. 61
9203990 1997
34
Dopamine D1, dopamine D2, and prolactin receptor messenger ribonucleic acid expression by the polymerase chain reaction in human meningiomas. 54
8869066 1996
35
Results of craniotomy for the treatment of cerebral meningioma in 42 cats. 61
8191679 1994
36
[Diagnosis of cerebral meningioma before hospitalization]. 61
7785249 1994
37
Metastasis of breast carcinoma to intracranial meningioma. Case report. 61
7838405 1994
38
Wound infection with meningitis caused by Salmonella typhimurium. 61
8338654 1993
39
[2 cases of coexistence of meningioma and glioma]. 61
1660111 1991
40
[Intracranial hemorrhages in cerebral meningioma]. 61
1664596 1991
41
Treatment of intracranial meningiomas in patients over 70 years old. 61
2096608 1990
42
Conjunctival flap-cosmetic shell-ptosis procedure. Treatment of blepharoptosis in severe keratopathy. 61
2597074 1989
43
[Anatomo-clinical conference. Hôpital Cochin. Case No. 3-1989. Cerebral meningioma and adrenal mass in a 70-year-old woman]. 61
2782771 1989
44
[Migraine and epilepsy in cerebral meningioma]. 61
3129348 1988
45
Neurosurgical, obstetric and endocrine aspects of meningioma during pregnancy. 61
3319945 1987
46
[Cerebral meningioma associated with thrombocytosis]. 61
2952986 1987
47
Radiation-induced cerebral meningioma: a recognizable entity. 61
6593438 1984
48
[Febrile cerebral arterial accident disclosing myxoma of the left atrium. Association with cerebral meningioma and lipoma]. 61
6239258 1984
49
Fatal hypereosinophilia with chromosome 15q- in a patient with multiple primary and familial neoplasms. 61
6297705 1983
50
Metastasis of carcinoma of cervix uteri to convexity meningioma. 61
918829 1977

Variations for Cerebral Meningioma

Expression for Cerebral Meningioma

Search GEO for disease gene expression data for Cerebral Meningioma.

Pathways for Cerebral Meningioma

Pathways related to Cerebral Meningioma according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 OSM LIFR LIF IL6R IGF1 EGF
2
Show member pathways
13.08 OSM LIFR LIF IL6R IGF1 EGF
3
Show member pathways
12.99 PRLR OSM LIFR LIF IL6R EGF
4
Show member pathways
12.91 OSM LIFR LIF IL6R IGF1 EGF
5
Show member pathways
12.67 PRLR OSM IL6R IGF1 EGF
6
Show member pathways
12.66 NF2 LIFR IGF1 EGF
7
Show member pathways
12.1 IGF1 EGF DRD1
8
Show member pathways
12.09 IL6R IGF1 EGF
9
Show member pathways
11.94 LIF IGF1 EGF
10 11.88 LIFR LIF IGF1
11 11.84 LIF IGF1 EGF
12
Show member pathways
11.83 PRLR OSM LIFR LIF IL6R EGF
13 11.76 OSM LIF IL6R
14 11.73 NF2 IGF1 EGF
15 11.71 IL6R IGF1 EGF
16
Show member pathways
11.69 PRLR PGR EGF
17 11.32 PRLR EGF
18
Show member pathways
11.22 OSM LIFR LIF IL6R
19 11.14 PRLR OSM LIFR LIF IGF1
20 11.11 PRLR PGR
21 11.11 IL6R IGF1 EGF
22
Show member pathways
10.99 IGF1 EGF
23 10.84 OSM LIFR
24 10.62 OSM LIFR LIF IGF1 EGF

GO Terms for Cerebral Meningioma

Cellular components related to Cerebral Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 PRLR OSM LIFR LIF IL6R IGF1
2 receptor complex GO:0043235 8.92 PRLR LIFR IL6R EGF

Biological processes related to Cerebral Meningioma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.81 LIF IGF1 EGF DRD1
2 positive regulation of cell migration GO:0030335 9.74 IGF1 EGF DRD1
3 cytokine-mediated signaling pathway GO:0019221 9.65 PRLR OSM LIFR LIF IL6R
4 positive regulation of MAPK cascade GO:0043410 9.62 OSM LIF IGF1 EGF
5 embryo implantation GO:0007566 9.58 PRLR LIF
6 lung alveolus development GO:0048286 9.56 PGR LIF
7 positive regulation of DNA binding GO:0043388 9.55 IGF1 EGF
8 ERK1 and ERK2 cascade GO:0070371 9.54 IGF1 EGF
9 positive regulation of mitotic nuclear division GO:0045840 9.52 IGF1 EGF
10 positive regulation of cell proliferation GO:0008284 9.5 PRLR OSM LIFR LIF IL6R IGF1
11 mammary gland alveolus development GO:0060749 9.49 PRLR EGF
12 activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 9.48 PRLR EGF
13 negative regulation of hormone secretion GO:0046888 9.46 OSM LIF
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.46 OSM LIF IL6R IGF1
15 ciliary neurotrophic factor-mediated signaling pathway GO:0070120 9.43 LIFR IL6R
16 leukemia inhibitory factor signaling pathway GO:0048861 9.4 LIFR LIF
17 oncostatin-M-mediated signaling pathway GO:0038165 9.37 OSM LIFR
18 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.02 OSM LIF IL6R IGF1 EGF

Molecular functions related to Cerebral Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor activity GO:0004896 9.43 PRLR LIFR IL6R
2 ciliary neurotrophic factor receptor binding GO:0005127 9.4 PRLR LIFR
3 oncostatin-M receptor activity GO:0004924 9.37 PRLR LIFR
4 leukemia inhibitory factor receptor activity GO:0004923 9.32 PRLR LIFR
5 ciliary neurotrophic factor receptor activity GO:0004897 9.16 LIFR IL6R
6 cytokine binding GO:0019955 9.13 PRLR LIFR IL6R
7 growth factor activity GO:0008083 8.92 OSM LIF IGF1 EGF

Sources for Cerebral Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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