MCID: CRB002
MIFTS: 28

Cerebral Primitive Neuroectodermal Tumor

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Cerebral Primitive Neuroectodermal Tumor

MalaCards integrated aliases for Cerebral Primitive Neuroectodermal Tumor:

Name: Cerebral Primitive Neuroectodermal Tumor 12 54 15 70
Pnet of Cerebrum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7398
MeSH 44 D018242
NCIt 50 C4970
UMLS 70 C0751675

Summaries for Cerebral Primitive Neuroectodermal Tumor

MalaCards based summary : Cerebral Primitive Neuroectodermal Tumor, also known as pnet of cerebrum, is related to rectum adenocarcinoma and hydrocephalus. An important gene associated with Cerebral Primitive Neuroectodermal Tumor is MYCN (MYCN Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are Interleukin-4 and 13 signaling and Pathways Affected in Adenoid Cystic Carcinoma. The drugs Etoposide and Thiotepa have been mentioned in the context of this disorder. Affiliated tissues include ovary, spinal cord and smooth muscle.

Related Diseases for Cerebral Primitive Neuroectodermal Tumor

Diseases related to Cerebral Primitive Neuroectodermal Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 rectum adenocarcinoma 30.3 MYC MSH2
2 hydrocephalus 10.2
3 signet ring cell adenocarcinoma 10.1 MUC1 MSH2
4 hydrocephalus, congenital, 1 10.1
5 oligodendroglioma 10.1
6 lynch syndrome 10.1
7 neuroblastoma 10.1
8 hypotonia 10.1
9 duodenum cancer 10.1 MUC1 MSH2
10 duodenum disease 10.1 MUC1 MSH2
11 liposarcoma 10.1 MYC MSH2
12 colorectal cancer 1 10.1 MUC1 MSH2
13 gallbladder signet ring cell adenocarcinoma 10.1 MYC MUC1
14 uterine corpus cancer 10.1 MYC MSH2
15 plasmablastic lymphoma 10.1 MYC MUC1
16 colonic benign neoplasm 10.1 MYC MSH2
17 keratoacanthoma 10.1 MYC MSH2
18 small intestine cancer 10.1 MUC1 MSH2
19 reticulosarcoma 10.0 MYC MUC1
20 ovarian cystadenocarcinoma 10.0 MYC MUC1
21 sclerosing perineurioma 10.0 S100B MUC1
22 perineurioma 10.0 S100B MUC1
23 localized hypertrophic neuropathy 10.0 S100B MUC1
24 reticular perineurioma 10.0 S100B MUC1
25 intracranial cysts 10.0 S100B MUC1
26 aggressive digital papillary adenocarcinoma 10.0 S100B MUC1
27 meningeal melanocytoma 10.0 S100B MUC1
28 non-functioning pituitary adenoma 10.0 S100B MUC1
29 cutaneous leiomyosarcoma 10.0 S100B MUC1
30 syringocystadenoma papilliferum 10.0 S100B MUC1
31 intraneural perineurioma 10.0 S100B MUC1
32 chordoid meningioma 10.0 S100B MUC1
33 anaplastic ependymoma 10.0 S100B MUC1
34 epithelioid malignant peripheral nerve sheath tumor 10.0 S100B MUC1
35 ossifying fibromyxoid tumor 10.0 S100B MUC1
36 polymorphous low-grade adenocarcinoma 10.0 S100B MUC1
37 eccrine porocarcinoma 10.0 S100B MUC1
38 chordoid glioma 10.0 S100B MUC1
39 dendritic cell tumor 10.0 S100B MUC1
40 fibrous meningioma 10.0 S100B MUC1
41 intestinal benign neoplasm 10.0 MYC MSH2
42 spiradenoma 10.0 S100B MUC1
43 pancreatic ductal carcinoma 10.0 MYC MUC1
44 optic nerve glioma 10.0 S100B MUC1
45 spindle cell rhabdomyosarcoma 10.0 S100B MUC1
46 ovarian small cell carcinoma 10.0 S100B MUC1
47 monophasic synovial sarcoma 10.0 S100B MUC1
48 clear cell meningioma 10.0 S100B MUC1
49 ovary adenocarcinoma 10.0 MYC MUC1
50 syringoma 10.0 S100B MUC1

Graphical network of the top 20 diseases related to Cerebral Primitive Neuroectodermal Tumor:



Diseases related to Cerebral Primitive Neuroectodermal Tumor

Symptoms & Phenotypes for Cerebral Primitive Neuroectodermal Tumor

Drugs & Therapeutics for Cerebral Primitive Neuroectodermal Tumor

Drugs for Cerebral Primitive Neuroectodermal Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 2 33419-42-0 36462
2
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
3
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
4
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
5 Alkylating Agents Phase 2
6 Etoposide phosphate Phase 2
7 Immunosuppressive Agents Phase 2
8 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of High-Risk Cerebral Primitive Neuroectodermal Tumors in Children Aged Over 5 Years Completed NCT00936156 Phase 2 Chemotherapy (carboplatin, etoposide, thiotepa)

Search NIH Clinical Center for Cerebral Primitive Neuroectodermal Tumor

Genetic Tests for Cerebral Primitive Neuroectodermal Tumor

Anatomical Context for Cerebral Primitive Neuroectodermal Tumor

MalaCards organs/tissues related to Cerebral Primitive Neuroectodermal Tumor:

40
Ovary, Spinal Cord, Smooth Muscle, Skeletal Muscle, Small Intestine, Pituitary, Brain

Publications for Cerebral Primitive Neuroectodermal Tumor

Articles related to Cerebral Primitive Neuroectodermal Tumor:

(show all 26)
# Title Authors PMID Year
1
Tumor disease and associated congenital abnormalities on prenatal MRI. 61
21316891 2012
2
Neurological complications without eclampsia during pregnancy in Turkey. 61
21159040 2011
3
Cerebral primitive neuroectodermal tumor in an adult with a heterozygous MSH2 mutation. 61
19390556 2009
4
Autologous hematopoietic stem cell transplantation for high-risk brain tumors in children. 61
17906911 2008
5
Neonatal macrocephaly: cerebral primitive neuroectodermal tumor or neuroblastoma as an infrequent cause--a case report and review of the literature. 61
17909991 2007
6
Temozolomide in resistant or relapsed pediatric solid tumors. 61
16047361 2006
7
Prenatal imaging of congenital cerebral primitive neuroectodermal tumor. 61
12711864 2003
8
Primitive neuroectodermal tumor of cerebrum with adipose tissue. 61
11175648 2001
9
Cerebral primitive neuroectodermal tumor in an adult male. A case report. 61
11127734 2000
10
High-dose chemotherapy with autologous hematopoietic stem-cell rescue for patients with malignant brain tumors. 61
10525848 1999
11
Gangliosides and neutral glycolipids in ependymal, neuronal and primitive neuroectodermal tumors. 61
10527455 1999
12
A cerebral primitive neuroectodermal tumor in a squirrel monkey (Saimiri sciureus). 61
10431699 1999
13
Rapid diagnosis of germline p53 mutation using the enzyme mismatch cleavage method. 61
8955618 1996
14
p53 gene mutation in cerebral primitive neuroectodermal tumor in Taiwan. 61
8640736 1996
15
Alternative RNA splicing of the hyaluronic acid receptor CD44 in the normal human brain and in brain tumors. 61
7536236 1995
16
Human interferon-beta therapy for cerebral primitive neuroectodermal tumors--two case reports. 61
7753313 1995
17
"Undifferentiated" cerebral primitive neuroectodermal tumor in a young adult--case report. 61
7533271 1994
18
Expression of N-myc, c-myc and c-erbB-1 proto-oncogenes in cerebral primitive neuroectodermal tumors (PNET). 54
7889335 1994
19
Adipose tissue and smooth muscle in a primitive neuroectodermal tumor of cerebrum. 61
8171973 1994
20
Neuraxis dissemination in pediatric brain tumors. Response to preirradiation chemotherapy. 61
1735073 1992
21
Cerebral primitive neuroectodermal tumor in an adult, with spinal cord metastasis after 18-year dormancy. 61
2170592 1990
22
Oncogene amplification in pediatric brain tumors. 61
2334901 1990
23
Congenital cerebral primitive neuroectodermal tumor with astrocytic differentiation and extracranial metastases. 61
2162735 1990
24
Ultrastructural study of nuclear evagination in neoplastic cells of a cerebral primitive neuroectodermal tumor. 61
2545397 1989
25
A midline cerebral primitive neuroectodermal tumor: immunohistochemical evidence for a germinal matrix origin. 61
2839313 1988
26
Preradiation chemotherapy for newly diagnosed childhood brain tumors. A modified Phase II trial. 61
6627214 1983

Variations for Cerebral Primitive Neuroectodermal Tumor

Expression for Cerebral Primitive Neuroectodermal Tumor

Search GEO for disease gene expression data for Cerebral Primitive Neuroectodermal Tumor.

Pathways for Cerebral Primitive Neuroectodermal Tumor

Pathways related to Cerebral Primitive Neuroectodermal Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.38 MYC MUC1
2 11.08 MYCN MYC
3 10.82 MYC MSH2
4
Show member pathways
10.6 MYC MSH2
5 9.32 MYCN MYC

GO Terms for Cerebral Primitive Neuroectodermal Tumor

Sources for Cerebral Primitive Neuroectodermal Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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