MCID: CRB132
MIFTS: 36

Cerebral Sinovenous Thrombosis

Categories: Blood diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Cerebral Sinovenous Thrombosis

MalaCards integrated aliases for Cerebral Sinovenous Thrombosis:

Name: Cerebral Sinovenous Thrombosis 60
Csvt 60

Characteristics:

Orphanet epidemiological data:

60
cerebral sinovenous thrombosis
Age of onset: All ages;

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 35 I67.6
Orphanet 60 ORPHA329217

Summaries for Cerebral Sinovenous Thrombosis

MalaCards based summary : Cerebral Sinovenous Thrombosis, also known as csvt, is related to thrombosis and papilledema. An important gene associated with Cerebral Sinovenous Thrombosis is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include t cells, brain and liver, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Cerebral Sinovenous Thrombosis

Diseases related to Cerebral Sinovenous Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
# Related Disease Score Top Affiliating Genes
1 thrombosis 30.8 APOH F2 F3 F5 PROS1
2 papilledema 30.4 APOH F2
3 protein c deficiency 30.3 F2 F5
4 antiphospholipid syndrome 29.9 APOH F2 F3 F5
5 thrombophilia 29.6 APOH F2 F3 F5 PROS1
6 may-thurner syndrome 10.4 APOH F5
7 acanthamoeba keratitis 10.4 APOH F5
8 pregnancy loss, recurrent 1 10.4 APOH F5
9 otitis media 10.3
10 carotid artery occlusion 10.3 APOH F5
11 legg-calve-perthes disease 10.3 APOH F5
12 autoimmune atherosclerosis 10.3 APOH IL10
13 deficiency anemia 10.3
14 iron deficiency anemia 10.3
15 nephrotic syndrome 10.3
16 iron metabolism disease 10.3
17 homocystinuria 10.3
18 meningitis 10.3
19 hypereosinophilic syndrome 10.3
20 head injury 10.3
21 discoid lupus erythematosus 10.3 APOH IL10
22 myelitis 10.3 APOH IL17A
23 paracetamol poisoning 10.3 F2 F5
24 hemoglobin e disease 10.2 F2 F5
25 cryptogenic cirrhosis 10.2 F2 F5
26 factor viii deficiency 10.2 F2 F5
27 porencephaly 10.2 F2 F5
28 sneddon syndrome 10.2 APOH F2
29 post-thrombotic syndrome 10.2 F2 F5
30 livedoid vasculitis 10.2 APOH F2
31 buerger disease 10.2 APOH F2
32 palladium allergic contact dermatitis 10.2 IL10 IL17A
33 dysfibrinogenemia 10.2 F2 F5
34 acquired hemophilia 10.2 F3 F5
35 leukemia, acute lymphoblastic 10.2
36 leukemia 10.2
37 mastoiditis 10.2
38 lymphocytic leukemia 10.2
39 neonatal antiphospholipid syndrome 10.2
40 acquired hemophilia a 10.2 F3 F5
41 neurosyphilis 10.2 IL10 IL17A
42 arteritic anterior ischemic optic neuropathy 10.2 F2 F5
43 hemophilia a 10.2 F3 F5
44 mixed connective tissue disease 10.2 APOH IL10
45 acute liver failure 10.2 F2 F5
46 cystic echinococcosis 10.2 IL10 IL17A
47 echinococcosis 10.2 IL10 IL17A
48 autoimmune disease of eyes, ear, nose and throat 10.2 IL10 IL17A
49 primary systemic mycosis 10.2 IL10 IL17A
50 factor xiii deficiency 10.2 F3 F5

Graphical network of the top 20 diseases related to Cerebral Sinovenous Thrombosis:



Diseases related to Cerebral Sinovenous Thrombosis

Symptoms & Phenotypes for Cerebral Sinovenous Thrombosis

MGI Mouse Phenotypes related to Cerebral Sinovenous Thrombosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.63 F2 F3 F5 IL10 PROS1 PROZ
2 homeostasis/metabolism MP:0005376 9.61 ABCC8 APOH F2 F3 F5 IL10
3 mortality/aging MP:0010768 9.23 APOH F2 F3 F5 IL10 IL17A

Drugs & Therapeutics for Cerebral Sinovenous Thrombosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Modern Ultrasound Techniques in the Evaluation of Cerebral Venous Sinuses in Neonates Completed NCT00555932 Not Applicable
2 Database for Stroke in Infants and Children Recruiting NCT00084292

Search NIH Clinical Center for Cerebral Sinovenous Thrombosis

Genetic Tests for Cerebral Sinovenous Thrombosis

Anatomical Context for Cerebral Sinovenous Thrombosis

MalaCards organs/tissues related to Cerebral Sinovenous Thrombosis:

42
T Cells, Brain, Liver, Eye, Spinal Cord, Prostate, Placenta

Publications for Cerebral Sinovenous Thrombosis

Articles related to Cerebral Sinovenous Thrombosis:

(show top 50) (show all 109)
# Title Authors Year
1
Endovascular Treatment of a Dural Arteriovenous Fistula after Cerebral Sinovenous Thrombosis in a Child. ( 30481758 )
2019
2
Qualitative protein C deficiency due to PROC c.577_579delAAG mutation not detected by chromogenic assays: A case of intractable cerebral sinovenous thrombosis. ( 30255615 )
2019
3
Cerebral sinovenous thrombosis as a complication of otitis media. ( 30656038 )
2019
4
The Role of Factor V Leiden, Prothrombin G20210A, and MTHFR C677T Mutations in Neonatal Cerebral Sinovenous Thrombosis. ( 31025572 )
2019
5
Circulating Levels of Interleukin-10 and -17 in Patients with Cerebral Sinovenous Thrombosis (CSVT) in Acute and Subacute Stages: A Prospective Case-Control Study. ( 30246697 )
2018
6
Child Neurology: Mimics of cerebral sinovenous thrombosis: A pediatric case series. ( 30323079 )
2018
7
Anatomical Venous Variants in Children With Cerebral Sinovenous Thrombosis. ( 30580715 )
2018
8
Clinical and neuroimaging characteristics of cerebral sinovenous thrombosis in neonates undergoing cardiac surgery. ( 29221746 )
2018
9
Symptomatic Cerebral Sinovenous Thrombosis Associated With L-Asparaginase In Children With Acute Lymphoblastic Leukemia: A Single Institution Experience Over 17 Years. ( 29554021 )
2018
10
Neonatal cerebral sinovenous thrombosis: the anticoagulation debate. ( 29675894 )
2018
11
Anticoagulation in the management of neonatal cerebral sinovenous thrombosis: a systematic review and meta-analysis. ( 29675941 )
2018
12
Conservative management of neonatal cerebral sinovenous thrombosis with coexisting thrombophilia. ( 29708897 )
2018
13
Cerebral sinovenous thrombosis in children and young adults with acute lymphoblastic leukaemia - a cohort study from the United Kingdom. ( 27392277 )
2017
14
Cerebral Sinovenous Thrombosis in the Asphyxiated Cooled Infants: A Prospective Observational Study. ( 27823842 )
2017
15
Patterns of retinal hemorrhage associated with pediatric cerebral sinovenous thrombosis. ( 28087346 )
2017
16
Pediatric cerebral sinovenous thrombosis following cranial surgery. ( 28091816 )
2017
17
Cerebral Sinovenous Thrombosis. ( 28798906 )
2017
18
Neonatal cerebral sinovenous thrombosis: Two cases, two different gene polymorphisms and risk factors. ( 29168367 )
2017
19
Radiological and clinical features of cerebral sinovenous thrombosis in newborns and older children. ( 26970861 )
2016
20
Prognostication Value of Descending Corticospinal Tract DWI Signal in Neonatal Cerebral Sinovenous Thrombosis. ( 27025187 )
2016
21
Cerebral sinovenous thrombosis (CSVT) in children: what the pediatric radiologists need to know. ( 27025499 )
2016
22
Cerebral sinovenous thrombosis mimicking intracranial mass. ( 27312828 )
2016
23
Cerebral Sinovenous Thrombosis in Neonates and Children. ( 27396366 )
2016
24
Contralateral Hypoplastic Venous Draining Sinuses Are Associated with Elevated Intracranial Pressure in Unilateral Cerebral Sinovenous Thrombosis. ( 27469210 )
2016
25
Cerebral Sinovenous Thrombosis Mimicking Intracranial Mass. ( 27604041 )
2016
26
Cerebral sinovenous thrombosis in neonatal antiphospholipid syndrome: a new entity? ( 25504650 )
2015
27
Cerebral sinovenous thrombosis in children and neonates: clinical experience, laboratory, treatment, and outcome. ( 24550550 )
2015
28
Inaugural cerebral sinovenous thrombosis revealing homocystinuria in a 2-year-old boy. ( 24598125 )
2015
29
Paediatric cerebral sinovenous thrombosis: findings of the International Paediatric Stroke Study. ( 25288688 )
2015
30
Neuroimaging findings in pediatric cerebral sinovenous thrombosis. ( 25715842 )
2015
31
Paediatric arterial ischaemic stroke and cerebral sinovenous thrombosis. First report from the Italian Registry of Pediatric Thrombosis (R. I. T. I., Registro Italiano Trombosi Infantili). ( 25761414 )
2015
32
Acute paraplegia in a preterm infant with cerebral sinovenous thrombosis. ( 26012477 )
2015
33
A novel association between cerebral sinovenous thrombosis and nonketotic hyperglycinemia in a neonate. ( 26213552 )
2015
34
Homocystinuria: A Rare Disorder Presenting as Cerebral Sinovenous Thrombosis. ( 26221164 )
2015
35
Cerebral sinovenous thrombosis in a child with Crohn's disease, otitis media, and meningitis. ( 26246095 )
2015
36
Cerebral sinovenous thrombosis in a child with homocystinuria. ( 26265866 )
2015
37
Cerebral Sinovenous Thrombosis in a Patient with Transient Eosinophilia. ( 26278316 )
2015
38
Cerebral sinovenous thrombosis associated with iron deficiency anemia secondary to severe menorrhagia: a case report. ( 24056151 )
2014
39
A novel activating ABCC8 mutation underlying neonatal diabetes mellitus in an infant presenting with cerebral sinovenous thrombosis. ( 24468609 )
2014
40
Tachyarrhythmia-induced cerebral sinovenous thrombosis in a neonate without cardiac malformation. ( 24877884 )
2014
41
Anticoagulant therapy in head injury-associated cerebral sinovenous thrombosis in children. ( 25111001 )
2014
42
Cerebral sinovenous thrombosis in a patient with transient eosinophilia. ( 25224203 )
2014
43
Abducens palsy as a clue of unexpected contralateral cerebral sinovenous thrombosis. ( 23682669 )
2013
44
Cerebral sinovenous thrombosis associated with MTHFR A1298C mutation in the newborn: a case report. ( 22797907 )
2013
45
Potential pitfalls in imaging of paediatric cerebral sinovenous thrombosis. ( 22948810 )
2013
46
Cerebral sinovenous thrombosis associated with mastoiditis due to recurrent otitis media. ( 23011163 )
2013
47
Cerebral sinovenous thrombosis in pediatric practice. ( 23212594 )
2013
48
Serial cranial US for detection of cerebral sinovenous thrombosis in preterm infants. ( 23985276 )
2013
49
Extensive cerebral Sinovenous Thrombosis in a 5 Year Old Girl, Following Mild Dehydration. (Case Report and Review of Literature). ( 24693409 )
2013
50
Isolated cerebral sinovenous thrombosis: a rare case of neonatal antiphospholipid syndrome. ( 22700668 )
2012

Variations for Cerebral Sinovenous Thrombosis

Expression for Cerebral Sinovenous Thrombosis

Search GEO for disease gene expression data for Cerebral Sinovenous Thrombosis.

Pathways for Cerebral Sinovenous Thrombosis

Pathways related to Cerebral Sinovenous Thrombosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 APOH F2 F3 F5 PROS1
2
Show member pathways
12.34 F2 F3 F5 PROS1
3
Show member pathways
11.66 F2 F3 F5 PROS1
4
Show member pathways
11.47 F2 PROS1 PROZ
5 11.4 F2 F3 F5 PROS1
6 11.05 ABCC8 F2
7 9.98 F2 PROS1 PROZ

GO Terms for Cerebral Sinovenous Thrombosis

Cellular components related to Cerebral Sinovenous Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 APOH F2 F3 F5 IL10 IL17A
2 endoplasmic reticulum lumen GO:0005788 9.43 F2 F5 PROZ
3 Golgi lumen GO:0005796 9.33 F2 PROS1 PROZ
4 extracellular space GO:0005615 9.23 APOH F2 F3 F5 IL10 IL17A

Biological processes related to Cerebral Sinovenous Thrombosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.67 F3 IL10 IL17A
2 platelet degranulation GO:0002576 9.5 APOH F5 PROS1
3 fibrinolysis GO:0042730 9.48 F2 PROS1
4 blood coagulation, intrinsic pathway GO:0007597 9.46 APOH F2
5 ER to Golgi vesicle-mediated transport GO:0006888 9.46 F2 F5 PROS1 PROZ
6 negative regulation of blood coagulation GO:0030195 9.43 APOH PROS1
7 positive regulation of blood coagulation GO:0030194 9.4 APOH F2
8 regulation of blood coagulation GO:0030193 9.37 APOH F2
9 blood coagulation GO:0007596 9.35 F2 F3 F5 PROS1 PROZ
10 negative regulation of fibrinolysis GO:0051918 9.26 APOH F2
11 hemostasis GO:0007599 9.02 F2 F3 F5 PROS1 PROZ

Molecular functions related to Cerebral Sinovenous Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.8 F2 F3 PROZ

Sources for Cerebral Sinovenous Thrombosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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