MCID: CRB132
MIFTS: 33

Cerebral Sinovenous Thrombosis

Categories: Neuronal diseases, Rare diseases, Blood diseases

Aliases & Classifications for Cerebral Sinovenous Thrombosis

MalaCards integrated aliases for Cerebral Sinovenous Thrombosis:

Name: Cerebral Sinovenous Thrombosis 59
Csvt 59

Characteristics:

Orphanet epidemiological data:

59
cerebral sinovenous thrombosis
Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA329217
ICD10 via Orphanet 34 I67.6

Summaries for Cerebral Sinovenous Thrombosis

MalaCards based summary : Cerebral Sinovenous Thrombosis, also known as csvt, is related to papilledema and thrombosis. An important gene associated with Cerebral Sinovenous Thrombosis is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include brain, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Cerebral Sinovenous Thrombosis

Diseases related to Cerebral Sinovenous Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
# Related Disease Score Top Affiliating Genes
1 papilledema 29.8 APOH F2
2 thrombosis 28.7 APOH F2 F3 F5 PROS1
3 antiphospholipid syndrome 28.5 APOH F2 F3 F5
4 thrombophilia 27.6 APOH F2 F3 F5 PROS1
5 cerebritis 10.9
6 may-thurner syndrome 10.5 APOH F5
7 acanthamoeba keratitis 10.5 APOH F5
8 pregnancy loss, recurrent 1 10.5 APOH F5
9 carotid artery occlusion 10.5 APOH F5
10 acquired hemophilia a 10.5 F3 F5
11 acquired hemophilia 10.4 F3 F5
12 factor xiii deficiency 10.4 F3 F5
13 hemophilia a 10.3 F3 F5
14 severe pre-eclampsia 10.3 APOH F5
15 thrombotic thrombocytopenic purpura 10.1 APOH F3
16 homocystinuria 10.1
17 meningitis 10.1
18 otitis media 10.1
19 iron deficiency anemia 10.1
20 iron metabolism disease 10.1
21 deficiency anemia 10.1
22 paracetamol poisoning 10.1 F2 F5
23 sudden sensorineural hearing loss 10.1 F2 F5
24 hemoglobin e disease 10.1 F2 F5
25 cryptogenic cirrhosis 10.0 F2 F5
26 factor viii deficiency 10.0 F2 F5
27 mastoiditis 10.0
28 head injury 10.0
29 neonatal antiphospholipid syndrome 10.0
30 lymphoblastic leukemia 10.0
31 nephrotic syndrome 10.0
32 leukemia, acute lymphoblastic 10.0
33 porencephaly 10.0 F2 F5
34 post-thrombotic syndrome 10.0 F2 F5
35 scott syndrome 10.0 F2 F5
36 patent foramen ovale 10.0 F2 F5
37 arteritic anterior ischemic optic neuropathy 10.0 F2 F5
38 splenic infarction 10.0 APOH F2
39 dysfibrinogenemia 10.0 F2 F5
40 catastrophic antiphospholipid syndrome 10.0 APOH F3 F5
41 intracranial thrombosis 10.0 APOH F3 F5
42 acute liver failure 9.9 F2 F5
43 factor xii deficiency 9.9 APOH F3 F5
44 protein c deficiency 9.9 F2 F5
45 placenta disease 9.9 APOH F3 F5
46 buerger disease 9.9 APOH F2
47 cerebral falx meningioma 9.9 F2 F3
48 intestinal impaction 9.9 F2 F3
49 fournier gangrene 9.9 F2 F3
50 leech infestation 9.9 F2 F3

Graphical network of the top 20 diseases related to Cerebral Sinovenous Thrombosis:



Diseases related to Cerebral Sinovenous Thrombosis

Symptoms & Phenotypes for Cerebral Sinovenous Thrombosis

MGI Mouse Phenotypes related to Cerebral Sinovenous Thrombosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.35 F2 F3 F5 PROS1 PROZ
2 homeostasis/metabolism MP:0005376 9.17 ABCC8 APOH F2 F3 F5 PROS1

Drugs & Therapeutics for Cerebral Sinovenous Thrombosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Modern Ultrasound Techniques in the Evaluation of Cerebral Venous Sinuses in Neonates Completed NCT00555932 Not Applicable
2 Database for Stroke in Infants and Children Recruiting NCT00084292

Search NIH Clinical Center for Cerebral Sinovenous Thrombosis

Genetic Tests for Cerebral Sinovenous Thrombosis

Anatomical Context for Cerebral Sinovenous Thrombosis

MalaCards organs/tissues related to Cerebral Sinovenous Thrombosis:

41
Brain

Publications for Cerebral Sinovenous Thrombosis

Articles related to Cerebral Sinovenous Thrombosis:

(show top 50) (show all 99)
# Title Authors Year
1
Neonatal cerebral sinovenous thrombosis: the anticoagulation debate. ( 29675894 )
2018
2
Conservative management of neonatal cerebral sinovenous thrombosis with coexisting thrombophilia. ( 29708897 )
2018
3
Clinical and neuroimaging characteristics of cerebral sinovenous thrombosis in neonates undergoing cardiac surgery. ( 29221746 )
2018
4
Anticoagulation in the management of neonatal cerebral sinovenous thrombosis: a systematic review and meta-analysis. ( 29675941 )
2018
5
Symptomatic Cerebral Sinovenous Thrombosis Associated With L-Asparaginase In Children With Acute Lymphoblastic Leukemia: A Single Institution Experience Over 17 Years. ( 29554021 )
2018
6
Neonatal cerebral sinovenous thrombosis: Two cases, two different gene polymorphisms and risk factors. ( 29168367 )
2017
7
Cerebral Sinovenous Thrombosis in the Asphyxiated Cooled Infants: A Prospective Observational Study. ( 27823842 )
2017
8
Cerebral Sinovenous Thrombosis. ( 28798906 )
2017
9
Pediatric cerebral sinovenous thrombosis following cranial surgery. ( 28091816 )
2017
10
Patterns of retinal hemorrhage associated with pediatric cerebral sinovenous thrombosis. ( 28087346 )
2017
11
Cerebral Sinovenous Thrombosis Mimicking Intracranial Mass. ( 27604041 )
2016
12
Radiological and clinical features of cerebral sinovenous thrombosis in newborns and older children. ( 26970861 )
2016
13
Contralateral Hypoplastic Venous Draining Sinuses Are Associated with Elevated Intracranial Pressure in Unilateral Cerebral Sinovenous Thrombosis. ( 27469210 )
2016
14
Prognostication Value of Descending Corticospinal Tract DWI Signal in Neonatal Cerebral Sinovenous Thrombosis: A Case Report. ( 27025187 )
2016
15
Cerebral sinovenous thrombosis in children and young adults with acute lymphoblastic leukaemia - a cohort study from the United Kingdom. ( 27392277 )
2016
16
Cerebral sinovenous thrombosis mimicking intracranial mass. ( 27312828 )
2016
17
Cerebral Sinovenous Thrombosis in Neonates and Children. ( 27396366 )
2016
18
Cerebral sinovenous thrombosis (CSVT) in children: what the pediatric radiologists need to know. ( 27025499 )
2016
19
Paediatric arterial ischaemic stroke and cerebral sinovenous thrombosis. First report from the Italian Registry of Pediatric Thrombosis (R.a88I.a88T.a88I., Registro Italiano Trombosi Infantili). ( 25761414 )
2015
20
Homocystinuria: A Rare Disorder Presenting as Cerebral Sinovenous Thrombosis. ( 26221164 )
2015
21
Cerebral sinovenous thrombosis in a child with homocystinuria. ( 26265866 )
2015
22
Cerebral Sinovenous Thrombosis in a Patient with Transient Eosinophilia. ( 26278316 )
2015
23
Acute paraplegia in a preterm infant with cerebral sinovenous thrombosis. ( 26012477 )
2015
24
Cerebral sinovenous thrombosis in a child with Crohn's disease, otitis media, and meningitis. ( 26246095 )
2015
25
A novel association between cerebral sinovenous thrombosis and nonketotic hyperglycinemia in a neonate. ( 26213552 )
2015
26
Neuroimaging findings in pediatric cerebral sinovenous thrombosis. ( 25715842 )
2015
27
Cerebral sinovenous thrombosis in neonatal antiphospholipid syndrome: a new entity? ( 25504650 )
2015
28
Tachyarrhythmia-induced cerebral sinovenous thrombosis in a neonate without cardiac malformation. ( 24877884 )
2014
29
Inaugural Cerebral Sinovenous Thrombosis Revealing Homocystinuria in a 2-Year-Old Boy. ( 24598125 )
2014
30
Paediatric cerebral sinovenous thrombosis: findings of the International Paediatric Stroke Study. ( 25288688 )
2014
31
Anticoagulant therapy in head injury-associated cerebral sinovenous thrombosis in children. ( 25111001 )
2014
32
Cerebral Sinovenous Thrombosis in Children and Neonates: Clinical Experience, Laboratory, Treatment, and Outcome. ( 24550550 )
2014
33
A novel activating ABCC8 mutation underlying neonatal diabetes mellitus in an infant presenting with cerebral sinovenous thrombosis. ( 24468609 )
2014
34
Cerebral sinovenous thrombosis in a patient with transient eosinophilia. ( 25224203 )
2014
35
Abducens palsy as a clue of unexpected contralateral cerebral sinovenous thrombosis. ( 23682669 )
2013
36
Cerebral sinovenous thrombosis in pediatric practice. ( 23212594 )
2013
37
Potential pitfalls in imaging of paediatric cerebral sinovenous thrombosis. ( 22948810 )
2013
38
Serial cranial US for detection of cerebral sinovenous thrombosis in preterm infants. ( 23985276 )
2013
39
Cerebral sinovenous thrombosis associated with mastoiditis due to recurrent otitis media. ( 23011163 )
2013
40
Extensive cerebral Sinovenous Thrombosis in a 5 Year Old Girl, Following Mild Dehydration. (Case Report and Review of Literature). ( 24693409 )
2013
41
Cerebral sinovenous thrombosis associated with MTHFR A1298C mutation in the newborn: a case report. ( 22797907 )
2013
42
Cerebral Sinovenous Thrombosis Associated With Iron Deficiency Anemia Secondary to Severe Menorrhagia: A Case Report. ( 24056151 )
2013
43
EPNS/SFNP guideline on the anticoagulant treatment of cerebral sinovenous thrombosis in children and neonates. ( 22425391 )
2012
44
Cerebral sinovenous thrombosis (CSVT) in a neonate with different manifestations. ( 22837125 )
2012
45
Isolated cerebral sinovenous thrombosis: a rare case of neonatal antiphospholipid syndrome. ( 22700668 )
2012
46
Predictors of quality of life in pediatric survivors of arterial ischemic stroke and cerebral sinovenous thrombosis. ( 21836124 )
2011
47
The spectrum of associated brain lesions in cerebral sinovenous thrombosis: relation to gestational age and outcome. ( 21317440 )
2011
48
Paediatric arterial ischaemic stroke and cerebral sinovenous thrombosis in Denmark 1994-2006: a nationwide population-based study. ( 21114523 )
2011
49
Impact of anticoagulation on the short-term outcome in a population of neonates with cerebral sinovenous thrombosis: a retrospective study. ( 21551369 )
2011
50
Coexistance of cerebral sinovenous thrombosis and Dandy Walker malformation in newborn. ( 21648352 )
2011

Variations for Cerebral Sinovenous Thrombosis

Expression for Cerebral Sinovenous Thrombosis

Search GEO for disease gene expression data for Cerebral Sinovenous Thrombosis.

Pathways for Cerebral Sinovenous Thrombosis

Pathways related to Cerebral Sinovenous Thrombosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.8 APOH F2 F3 F5 PROS1
2
Show member pathways
12.39 F2 F3 F5 PROS1
3
Show member pathways
11.66 F2 F3 F5 PROS1
4
Show member pathways
11.47 F2 PROS1 PROZ
5 11.4 F2 F3 F5 PROS1
6 11.05 ABCC8 F2
7 9.98 F2 PROS1 PROZ

GO Terms for Cerebral Sinovenous Thrombosis

Cellular components related to Cerebral Sinovenous Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 APOH F2 F3 F5 PROS1 PROZ
2 endoplasmic reticulum lumen GO:0005788 9.43 F2 F5 PROZ
3 platelet alpha granule lumen GO:0031093 9.32 F5 PROS1
4 Golgi lumen GO:0005796 9.13 F2 PROS1 PROZ
5 extracellular space GO:0005615 9.1 APOH F2 F3 F5 PROS1 PROZ

Biological processes related to Cerebral Sinovenous Thrombosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 ER to Golgi vesicle-mediated transport GO:0006888 9.67 F2 F5 PROS1 PROZ
2 platelet degranulation GO:0002576 9.61 APOH F5 PROS1
3 fibrinolysis GO:0042730 9.51 F2 PROS1
4 signal peptide processing GO:0006465 9.5 F2 PROS1 PROZ
5 blood coagulation, intrinsic pathway GO:0007597 9.49 APOH F2
6 positive regulation of blood coagulation GO:0030194 9.48 APOH F2
7 regulation of blood coagulation GO:0030193 9.46 APOH F2
8 negative regulation of blood coagulation GO:0030195 9.43 APOH PROS1 PROZ
9 negative regulation of fibrinolysis GO:0051918 9.4 APOH F2
10 blood coagulation GO:0007596 9.35 F2 F3 F5 PROS1 PROZ
11 peptidyl-glutamic acid carboxylation GO:0017187 9.33 F2 PROS1 PROZ
12 hemostasis GO:0007599 9.02 F2 F3 F5 PROS1 PROZ

Molecular functions related to Cerebral Sinovenous Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.8 F2 F3 PROZ

Sources for Cerebral Sinovenous Thrombosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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