CSVT
MCID: CRB132
MIFTS: 31

Cerebral Sinovenous Thrombosis (CSVT)

Categories: Blood diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Cerebral Sinovenous Thrombosis

MalaCards integrated aliases for Cerebral Sinovenous Thrombosis:

Name: Cerebral Sinovenous Thrombosis 58
Csvt 58

Characteristics:

Orphanet epidemiological data:

58
cerebral sinovenous thrombosis
Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 33 I67.6
Orphanet 58 ORPHA329217

Summaries for Cerebral Sinovenous Thrombosis

MalaCards based summary : Cerebral Sinovenous Thrombosis, also known as csvt, is related to mastoiditis and papilledema. An important gene associated with Cerebral Sinovenous Thrombosis is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include heart, monocytes and brain, and related phenotypes are homeostasis/metabolism and integument

Related Diseases for Cerebral Sinovenous Thrombosis

Diseases related to Cerebral Sinovenous Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 272)
# Related Disease Score Top Affiliating Genes
1 mastoiditis 30.8 MTHFR F2
2 papilledema 30.7 F3 F2 APOH
3 sagittal sinus thrombosis 30.5 F5 F3 F2
4 thrombosis 30.4 PROS1 MTHFR F5 F3 F2 APOH
5 prothrombin thrombophilia 30.3 MTHFR F2
6 protein c deficiency 30.1 MTHFR F5 F2 APOH
7 cerebral palsy 29.9 MTHFR IL10 F5 F2
8 antithrombin iii deficiency 29.8 MTHFR F5 F2 APOH
9 homocysteinemia 29.8 MTHFR F5 F2 APOH
10 cerebrovascular disease 29.8 MTHFR F5 F2 APOH
11 antiphospholipid syndrome 29.7 MTHFR F5 F3 F2 APOH
12 thrombophilia due to thrombin defect 29.7 MTHFR F5 F3 F2 APOH
13 intracranial hypertension 29.7 MTHFR F5 F3 F2 APOH ABCC8
14 migraine with or without aura 1 29.7 MTHFR IL10 F2 APOH
15 thrombophilia 29.6 PROS1 MTHFR F5 F3 F2 APOH
16 intracranial thrombosis 29.5 MTHFR F5 F3 F2 APOH
17 thrombophilia due to activated protein c resistance 29.5 MTHFR F5 F3 F2 APOH
18 vascular disease 29.1 MTHFR IL10 F5 F3 F2 APOH
19 stroke, ischemic 29.1 PROZ MTHFR F5 F3 F2 APOH
20 protein s deficiency 29.1 PROS1 MTHFR F5 F3 F2 APOH
21 inflammatory bowel disease 29.0 MTHFR IL17A IL10 F5 F3 F2
22 diabetes mellitus 28.9 MTHFR IL17A IL10 F3 F2 ABCC8
23 pulmonary embolism 28.8 PROS1 MTHFR F5 F3 F2 APOH
24 nephrotic syndrome 10.5
25 deficiency anemia 10.4
26 otitis media 10.4
27 iron deficiency anemia 10.4
28 iron metabolism disease 10.4
29 head injury 10.4
30 paracetamol poisoning 10.3 F5 F2
31 aspirin resistance 10.3 F5 F2
32 may-thurner syndrome 10.3 F5 APOH
33 acanthamoeba keratitis 10.3 F5 APOH
34 prothrombin deficiency 10.3 F3 F2
35 ocular motor apraxia 10.3
36 homocystinuria 10.3
37 meningitis 10.3
38 hypereosinophilic syndrome 10.3
39 achenbach syndrome 10.3 F3 F2
40 pregnancy loss, recurrent 1 10.3 F5 APOH
41 renal pelvis squamous cell carcinoma 10.3 F3 F2
42 synovial angioma 10.3 F3 F2
43 papillary adenofibroma 10.3 F3 F2
44 femoral neuropathy 10.3 F3 F2
45 emphysematous cholecystitis 10.3 F3 F2
46 giant hemangioma 10.3 F3 F2
47 hemopneumothorax 10.3 F3 F2
48 dic in newborn 10.3 F3 F2
49 cerebral falx meningioma 10.3 F3 F2
50 acquired hemophilia 10.3 F5 F3

Graphical network of the top 20 diseases related to Cerebral Sinovenous Thrombosis:



Diseases related to Cerebral Sinovenous Thrombosis

Symptoms & Phenotypes for Cerebral Sinovenous Thrombosis

MGI Mouse Phenotypes related to Cerebral Sinovenous Thrombosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.85 ABCC8 APOH F2 F3 F5 IL10
2 integument MP:0010771 9.56 ASPG F2 F3 F5 IL10 IL17A
3 mortality/aging MP:0010768 9.28 APOH F2 F3 F5 IL10 IL17A

Drugs & Therapeutics for Cerebral Sinovenous Thrombosis

Search Clinical Trials , NIH Clinical Center for Cerebral Sinovenous Thrombosis

Genetic Tests for Cerebral Sinovenous Thrombosis

Anatomical Context for Cerebral Sinovenous Thrombosis

MalaCards organs/tissues related to Cerebral Sinovenous Thrombosis:

40
Heart, Monocytes, Brain, Spinal Cord, Liver, Placenta, Pituitary

Publications for Cerebral Sinovenous Thrombosis

Articles related to Cerebral Sinovenous Thrombosis:

(show top 50) (show all 299)
# Title Authors PMID Year
1
Pediatric Ischemic Stroke: An Infrequent Complication of SARS-CoV-2. 61
33332607 2021
2
Swallowing, Oral Motor, Motor Speech, and Language Impairments Following Acute Pediatric Ischemic Stroke. 61
33641384 2021
3
Clinical Diversity of Cerebral Sinovenous Thrombosis and Arterial Ischaemic Stroke in the Neonate: A Surveillance Study. 61
33784682 2021
4
Pediatric Otogenic Cerebral Sinus Vein Thrombosis and Thrombophilia. 61
33595215 2021
5
Correspondence on "Too Much of a Good Thing? Cerebral Sinovenous Thrombosis Due to Excessive Milk Intake Associated Anemia". 61
32880503 2021
6
Response to Correspondence on "Too Much of a Good Thing? Cerebral Sinovenous Thrombosis Due to Excessive Milk Intake Associated Anemia". 61
32851905 2021
7
Incidence and risk factors of cerebral sinovenous thrombosis in infants. 61
33506500 2021
8
Venous thrombosis in neonates. 61
33718937 2021
9
Cerebral Sinovenous Thrombosis due to Hypernatremic Dehydration in a Neonate. 61
33642292 2021
10
Unilateral persistent disc oedema due to cerebral sinus venous thrombosis (CSVT): diagnostic and management challenge. 61
33372010 2020
11
Long-term cognitive outcomes after cerebral sinovenous thrombosis in childhood. 61
32909303 2020
12
Population Based Birth Prevalence of Disease-Specific Perinatal Stroke. 61
33115795 2020
13
Deep medullary vein engorgement and superficial medullary vein engorgement: two patterns of perinatal venous stroke. 61
33090246 2020
14
Cancer and Tumor-Associated Childhood Stroke: Results From the International Pediatric Stroke Study. 61
32951663 2020
15
Risk factors for pediatric cerebral sinovenous thrombosis: A case-control study with case validation. 61
32554256 2020
16
Jak2 mutation expands the thrombophilic panel in children. 61
32654426 2020
17
Point-of-care ultrasound in the diagnosis of neonatal cerebral sinovenous thrombosis. 61
32357253 2020
18
Too Much of a Good Thing? Cerebral Sinovenous Thrombosis Due to Excessive Milk Intake Associated Anemia. 61
32429785 2020
19
Bleeder With a Clot: Thrombosis Following Treatment of Bleeding in a Child With Severe Hemophilia B. 61
32769563 2020
20
Factors associated with pregnancy outcomes in women with a history of cerebral sinus venous thrombosis. 61
31655969 2020
21
Cerebrovascular Complications of Pediatric Blunt Trauma. 61
32111560 2020
22
Treatment and outcome of childhood cerebral sinovenous thrombosis. 61
32642325 2020
23
[Cerebral sinovenous thrombosis in a newborn with mutation of MTHFR C677T treated with enoxaparin]. 61
32730524 2020
24
Pediatric abusive head trauma. 61
32330675 2020
25
Cerebral sinovenous thrombosis in pediatric hemolytic uremic syndrome. 61
32548566 2020
26
Screening for paroxysmal nocturnal hemoglobinuria (PNH) in patients presenting with cerebral sinovenous thrombosis (CSVT): Results of a FLAER based flowcytometry study in Indian patients. 61
31701360 2020
27
Transient water-electrolyte disturbance after hemispherotomy in young infants with epileptic encephalopathy. 61
31845027 2020
28
Seizures and Outcome One Year After Neonatal and Childhood Cerebral Sinovenous Thrombosis. 61
31882182 2020
29
Outcome Trajectories after Primary Perinatal Hemorrhagic Stroke. 61
31952959 2020
30
Role of platelet gene polymorphisms in ischemic pediatric stroke subtypes: a case-control study. 61
32118374 2020
31
Epidemiology of neonatal stroke: A population-based study. 61
33390736 2020
32
Analysis of 10 Pediatric Nephrotic Syndrome Cases With Complications of Cerebral Sinovenous Thrombosis. 61
33425818 2020
33
COVID-19 and Cerebrovascular Diseases: A Systematic Review and Perspectives for Stroke Management. 61
33250845 2020
34
Cerebral Venous Thrombosis: A Comprehensive Review. 61
32877892 2020
35
Cerebral Venous Sinus Thrombosis in Women: Subgroup Analysis of the VENOST Study. 61
32953038 2020
36
Bivalirudin anticoagulation to overcome heparin resistance in a neonate with cerebral sinovenus thrombosis. 61
31833869 2020
37
Cerebral Venous Sinus Thrombosis Manifesting as a Recurrent Spontaneous Subdural Hematoma: A Case Report. 61
32066113 2020
38
Cerebral sinovenous thrombosis in a child with ulcerative colitis: A case report. 61
31914047 2020
39
Perinatal stroke. 61
32736758 2020
40
Paediatric stroke - a review of current guidelines for diagnosis and treatment. 61
31985031 2020
41
Perinatal Stroke. 61
31813521 2019
42
Incidence and features of thrombosis in children with inherited antithrombin deficiency. 61
30975910 2019
43
Pediatric cerebral sinovenous thrombosis: Optimal treatment may differ by etiology. 61
31323481 2019
44
Recurrent cerebral venous sinus thrombosis in a young man- A case report of JAK2-negative polycythemia vera. 61
31742182 2019
45
Characteristics and Outcome in Children With Craniectomy Following Acute Ischemic Stroke in the International Pediatric Stroke Study. 61
31282248 2019
46
Cause or Consequence: The Relationship Between Cerebral Venous Thrombosis and Idiopathic Intracranial Hypertension. 61
31479000 2019
47
Highly Anisotropic P3HT Film Fabricated via Epitaxy on an Oriented Polyethylene Film and Solvent Vapor Treatment. 61
31082249 2019
48
Neurological complications in childhood nephrotic syndrome: A systematic review. 61
30837193 2019
49
PREVAPIX-ALL: Apixaban Compared to Standard of Care for Prevention of Venous Thrombosis in Paediatric Acute Lymphoblastic Leukaemia (ALL)-Rationale and Design. 61
30861550 2019
50
Short-term neurological outcomes in ischemic and hemorrhagic pediatric stroke. 61
30449056 2019

Variations for Cerebral Sinovenous Thrombosis

Expression for Cerebral Sinovenous Thrombosis

Search GEO for disease gene expression data for Cerebral Sinovenous Thrombosis.

Pathways for Cerebral Sinovenous Thrombosis

Pathways related to Cerebral Sinovenous Thrombosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 PROS1 F5 F3 F2 APOH
2
Show member pathways
12.36 PROS1 F5 F3 F2
3
Show member pathways
11.66 PROS1 F5 F3 F2
4
Show member pathways
11.47 PROZ PROS1 F2
5 11.42 PROS1 F5 F3 F2
6 9.98 PROZ PROS1 F2

GO Terms for Cerebral Sinovenous Thrombosis

Cellular components related to Cerebral Sinovenous Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 PROZ PROS1 IL17A IL10 F5 F3
2 Golgi lumen GO:0005796 9.33 PROZ PROS1 F2
3 extracellular space GO:0005615 9.23 PROZ PROS1 IL17A IL10 F5 F3

Biological processes related to Cerebral Sinovenous Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.58 PROS1 F5 APOH
2 fibrinolysis GO:0042730 9.48 PROS1 F2
3 blood coagulation, intrinsic pathway GO:0007597 9.46 F2 APOH
4 ER to Golgi vesicle-mediated transport GO:0006888 9.46 PROZ PROS1 F5 F2
5 positive regulation of blood coagulation GO:0030194 9.43 F2 APOH
6 negative regulation of blood coagulation GO:0030195 9.37 PROS1 APOH
7 blood coagulation GO:0007596 9.35 PROZ PROS1 F5 F3 F2
8 regulation of blood coagulation GO:0030193 9.32 F2 APOH
9 negative regulation of fibrinolysis GO:0051918 9.26 F2 APOH
10 hemostasis GO:0007599 9.02 PROZ PROS1 F5 F3 F2

Molecular functions related to Cerebral Sinovenous Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.8 PROZ F3 F2

Sources for Cerebral Sinovenous Thrombosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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