MCID: CRB009
MIFTS: 37

Cerebritis

Categories: Neuronal diseases

Aliases & Classifications for Cerebritis

MalaCards integrated aliases for Cerebritis:

Name: Cerebritis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:3431
NCIt 49 C27199
UMLS 71 C0742115

Summaries for Cerebritis

Disease Ontology : 12 A brain disease that is characterized by inflammation of the brain tissue occurring as a result of an underlying condition.

MalaCards based summary : Cerebritis is related to cerebral lymphoma and cerebrovascular disease. An important gene associated with Cerebritis is CSTL1 (Cystatin Like 1), and among its related pathways/superpathways are T cell receptor signaling pathway and Hematopoietic Stem Cells and Lineage-specific Markers. The drugs Mechlorethamine and Valine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and bone marrow.

Wikipedia : 74 Cerebritis is the inflammation of the cerebrum which performs a number of important functions, such as... more...

Related Diseases for Cerebritis

Diseases related to Cerebritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 3865)
# Related Disease Score Top Affiliating Genes
1 cerebral lymphoma 33.9 CD40LG CD4
2 cerebrovascular disease 32.3 TNF CRP CD40LG APOH
3 aseptic meningitis 32.1 TNF CRP CD40LG
4 neurosarcoidosis 31.7 TNF CRP CD8A CD4
5 malaria 31.4 TNF CRP CD8A CD40LG CD4 C5AR1
6 plasmodium falciparum malaria 31.4 TNF CRP CD40LG
7 meningitis 31.3 TNF CRP CD40LG
8 mucormycosis 31.2 RHNO1 CRP CD4
9 cryptococcosis 31.1 TNF CD8A CD4
10 endocarditis 31.1 TNF CRP APOH
11 vasculitis 31.1 TNF CRP CD40LG APOH
12 arachnoiditis 30.9 CRP CD4
13 migraine with or without aura 1 30.9 TNF CRP CD40LG APOH
14 infective endocarditis 30.9 TNF CRP APOH
15 pulmonary embolism 30.9 CRP CD40LG APOH
16 patent foramen ovale 30.8 CRP CD40LG APOH
17 vascular disease 30.8 TNF CRP CD40LG CD4 APOH
18 asymptomatic neurosyphilis 30.7 CD40LG CD4
19 subdural empyema 30.7 RHNO1 CRP
20 sickle cell anemia 30.7 TNF CRP CD40LG
21 cavernous sinus thrombosis 30.7 RHNO1 CRP
22 papilledema 30.6 CRP CD40LG CD4 APOH
23 nocardiosis 30.6 TNF CRP CD4
24 pleural empyema 30.6 CRP CD40LG CD4
25 thrombophlebitis 30.6 TNF CRP CD40LG APOH
26 acquired immunodeficiency syndrome 30.6 TNF CRP CD40LG CD4
27 marantic endocarditis 30.5 CRP APOH
28 antiphospholipid syndrome 30.5 TNF CRP CD40LG APOH
29 toxic shock syndrome 30.5 TNF CRP CD40LG
30 mastoiditis 30.5 CRP CD40LG CD4
31 echinococcosis 30.5 TNF CD8A CD40LG
32 purpura 30.4 TNF CRP CD40LG APOH
33 myelitis 30.4 TNF CD40LG APOH
34 multiple cranial nerve palsy 30.4 RHNO1 CRP
35 subacute bacterial endocarditis 30.4 CRP CD40LG
36 toxocariasis 30.3 CRP CD40LG
37 respiratory failure 30.3 TNF CRP CD40LG CD4
38 central retinal artery occlusion 30.3 RHNO1 CRP CD40LG
39 maxillary sinusitis 30.3 CRP CD40LG
40 orbital cellulitis 30.3 RHNO1 CRP
41 cranial nerve palsy 30.3 RHNO1 CRP CD40LG CD4
42 neuroretinitis 30.2 CRP CD40LG CD4
43 intermittent claudication 30.2 CRP CD40LG APOH
44 tetanus 30.2 TNF CRP CD40LG
45 facial paralysis 30.2 CRP CD8A CD40LG CD4
46 transverse myelitis 30.2 TNF APOH
47 brucellosis 30.2 TNF CRP CD40LG
48 otitis media 30.2 TNF CRP CD40LG
49 ethmoid sinusitis 30.1 RHNO1 CRP
50 central nervous system tuberculosis 30.1 TNF CD4

Graphical network of the top 20 diseases related to Cerebritis:



Diseases related to Cerebritis

Symptoms & Phenotypes for Cerebritis

Drugs & Therapeutics for Cerebritis

Drugs for Cerebritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
2
Valine Approved, Nutraceutical Phase 2 72-18-4 6287
3 Pharmaceutical Solutions Phase 2
4
Serine Investigational, Nutraceutical Phase 2 56-45-1 5951
5
Arginine Investigational, Nutraceutical Phase 2 74-79-3 6322

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Immune Ablation and Hematopoietic Stem Cell Support in Patients With Poor Prognostic Indicators and Systemic Lupus Erythematosus:A Phase II Study Completed NCT00271934 Phase 2
2 A Phase 2, Randomized, Double Blind, Placebo , Controlled Study To Evaluate The Administration of CN-105 In Participants With Acute Supratentorial Intracerebral Hemorrhage Not yet recruiting NCT03711903 Phase 2 Acetyl-Valine-Serine-Arginine-Arginine-Arginine-NH2 (Ac-VSRRR- NH2).;0.9% Sodium-chloride
3 A Pilot Study of Inpatient Hospice With Procurement of Brain Tumor Tissue on Expiration for Research Purposes Terminated NCT01251913

Search NIH Clinical Center for Cerebritis

Genetic Tests for Cerebritis

Anatomical Context for Cerebritis

MalaCards organs/tissues related to Cerebritis:

40
Brain, Bone, Bone Marrow, Heart, Kidney, Liver, Neutrophil

Publications for Cerebritis

Articles related to Cerebritis:

(show top 50) (show all 392)
# Title Authors PMID Year
1
Rhino-orbital-cerebral mucormycosis (ROCM) and associated cerebritis treated with adjuvant retrobulbar amphotericin B. 61
32551404 2020
2
Aspergillus and Rhizopus Fungal Coinfection in a Patient With Multiple Myeloma. 61
32537269 2020
3
Multiple Intracranial Tuberculomas with an Intra-medullary Spinal Cord Tuberculoma in a Pediatric Patient. 61
32292663 2020
4
Holohemispheric Invasive Aspergillus Granulomatous Cerebritis of the Brain. 61
31562969 2020
5
Listeria Cerebritis with Tumor Necrosis Factor Inhibition. 61
32373374 2020
6
Invasion of Host Cells by Microsporidia. 61
32132983 2020
7
Dual-Use Intraoperative MRI in Glioblastoma Surgery: Results of Resection, Histopathologic Assessment, and Surgical Site Infections. 61
31272122 2019
8
A case report of multiple cerebral abscess formation complicating serogroup B Neisseria meningitidis meningitis. 61
31638913 2019
9
Comparison of CSF and MRI Findings among Neonates and Infants with E coli or Group B Streptococcal Meningitis. 61
31320464 2019
10
Suspected hematologic malignancy complicates lupus cerebritis treatment. 61
30913146 2019
11
Tocilizumab for the management of immune mediated adverse events secondary to PD-1 blockade. 61
29207939 2019
12
A versatile imaging platform with fluorescence and CT imaging capabilities that detects myeloperoxidase activity and inflammation at different scales. 61
31695784 2019
13
Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits. 61
30610193 2019
14
Fungal Rhino-orbital Cerebritis in a Patient with Steroid-induced Ketoacidosis. 61
30443618 2018
15
Fatal orbital cellulitis with intracranial complications: a case report. 61
31179919 2018
16
Fatal cryptococcal meningitis in an AIDS patient complicated with immune reconstitution syndrome refractory to prolonged amphotericin B treatment. 61
29749873 2018
17
Nanoscale mechanics of brain abscess: An atomic force microscopy study. 61
29957562 2018
18
Neuroinfections caused by fungi. 61
29785613 2018
19
Nickel-Related Adverse Reactions in the Treatment of Cerebral Aneurysms: A Literature Review. 61
29684517 2018
20
Therapeutic plasma exchange for pediatric nonrenal disease indications and outcomes: A single-center experience. 61
30692797 2018
21
Capnocytophaga canimorsus: An Emerging Pathogen in Immunocompetent Patients-Experience from an Emergency Department. 61
29523423 2018
22
Radiosurgery versus open surgery for mesial temporal lobe epilepsy: The randomized, controlled ROSE trial. 61
29600809 2018
23
Steroid-Induced Psychosis in the Pediatric Population: A New Case and Review of the Literature. 61
29638141 2018
24
Angiocentric lymph proliferative disorder (lymphomatoid granulomatosis) in a person with newly-diagnosed HIV infection: a case report. 61
29739366 2018
25
Simultaneous treatment of intracranial complications of paranasal sinusitis. 61
29536253 2018
26
Multiple cortical brain abscesses due to Listeria monocytogenes in an immunocompetent patient. 61
28849735 2018
27
Incidence and pattern of brain lesions in paediatric septic shock patients. 61
29293365 2018
28
Programmed Cell Death Ligand 1-Induced Coma From Diffuse Cerebritis. 61
29016224 2018
29
First Reported Case of Neuroleptospirosis Complicated With Anton's Syndrome. 61
30564184 2018
30
Nephritis, cerebritis, and myositis after adalimumab therapy in a patient with rheumatoid arthritis: a case report. 61
29692623 2018
31
The role of hydroxychloroquine in catastrophic antiphospholipid syndrome case: Series of two case reports and review of literature. 61
30046446 2018
32
Magnetic resonance imaging spectrum of intracranial tubercular lesions: one disease, many faces. 61
30800191 2018
33
Subdural empyema case report of a rare disease with a high mortality. 61
30442008 2018
34
An update on bacterial brain abscess in immunocompetent patients. 61
28501669 2017
35
A Pott's Puffy Tumor Associated with Epidural - Cutaneous Fistula and Epidural Abscess: Case Report. 61
28443599 2017
36
Neonatal cranial sonography: ultrasound findings in neonatal meningitis-a pictorial review. 61
28275563 2017
37
Expressive aphasia caused by Streptococcus intermedius brain abscess in an immunocompetent patient. 61
28176963 2017
38
A 54-year-old male with rapidly progressive neurologic syndrome: Clinicopathologic correlation of a rare diagnosis. 61
28195100 2017
39
Disseminated melioidosis in the head and neck. 61
28096229 2017
40
Parasitic and fungal infections. 61
28987173 2017
41
Antigen presentation for priming T cells in central system. 61
27903432 2017
42
Giant Recurrent Supratentorial Neurenteric Cyst As a Cause of Medically Refractory Epilepsy. 61
30047676 2016
43
Ischaemic stroke and Clostridium septicum sepsis and meningitis in a patient with occult colon carcinoma - a case report and review of the literature. 61
27881097 2016
44
Early cerebritis resulting in a first-time seizure in an otherwise healthy young man. 61
27840566 2016
45
Neurological sequelae of bacterial meningitis. 61
27105658 2016
46
From suspected Creutzfeldt-Jakob disease to confirmed histoplasma meningitis. 61
27389723 2016
47
Postneurosurgical Central Nervous System Infection Due to Enterococcus faecalis Successfully Treated With Intraventricular Vancomycin. 61
27226704 2016
48
Implant Site Infection and Bone Flap Osteomyelitis Associated with the NeuroPace Responsive Neurostimulation System. 61
26743382 2016
49
Pneumococcal meningitis: clinical-pathological correlations (MeninGene-Path). 61
27001057 2016
50
Mycoplasma pneumoniae, a trigger for Weston Hurst syndrome. 61
26819961 2016

Variations for Cerebritis

Expression for Cerebritis

Search GEO for disease gene expression data for Cerebritis.

Pathways for Cerebritis

GO Terms for Cerebritis

Cellular components related to Cerebritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.63 TNF SLC15A2 CD8A CD40LG CD4 C5AR1
2 external side of plasma membrane GO:0009897 9.26 TNF CD8A CD40LG CD4
3 cell surface GO:0009986 9.02 TNF CD40LG CD4 C5AR1 APOH

Biological processes related to Cerebritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 9.5 TNF CRP C5AR1
2 astrocyte activation GO:0048143 9.37 TNF C5AR1
3 inflammatory response GO:0006954 9.35 TNF CXCL2 CRP CD40LG C5AR1
4 negative regulation of lipid storage GO:0010888 9.26 TNF CRP
5 regulation of immunoglobulin secretion GO:0051023 9.16 TNF CD40LG
6 immune response GO:0006955 9.1 TNF CXCL2 CD8A CD40LG CD4 C5AR1

Sources for Cerebritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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