MCID: CRB009
MIFTS: 36

Cerebritis

Categories: Neuronal diseases

Aliases & Classifications for Cerebritis

MalaCards integrated aliases for Cerebritis:

Name: Cerebritis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:3431
NCIt 49 C27199
UMLS 71 C0742115

Summaries for Cerebritis

Disease Ontology : 12 A brain disease that is characterized by inflammation of the brain tissue occurring as a result of an underlying condition.

MalaCards based summary : Cerebritis is related to cerebral lymphoma and neurosarcoidosis. An important gene associated with Cerebritis is CSTL1 (Cystatin Like 1), and among its related pathways/superpathways are Creation of C4 and C2 activators and Immune response Lectin induced complement pathway. The drugs Mechlorethamine and Valine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and bone.

Wikipedia : 74 Cerebritis is an infection of the brain that normally leads to the formation of an abscess within the... more...

Related Diseases for Cerebritis

Diseases related to Cerebritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 3817)
# Related Disease Score Top Affiliating Genes
1 cerebral lymphoma 34.0 CD40LG CD4
2 neurosarcoidosis 32.0 CRP CD8A CD4
3 papilledema 31.1 CRP CD40LG CD4
4 nocardiosis 31.0 CRP CD4
5 asymptomatic neurosyphilis 30.8 CD40LG CD4
6 acquired immunodeficiency syndrome 30.8 CRP CD40LG CD4
7 mastoiditis 30.7 CRP CD4
8 subdural empyema 30.7 RHNO1 CRP
9 pleural empyema 30.7 CRP CD40LG CD4
10 cavernous sinus thrombosis 30.7 RHNO1 CRP
11 acute cystitis 30.5 CRP CD40LG CD4
12 subacute bacterial endocarditis 30.5 CRP CD40LG
13 toxocariasis 30.5 CRP CD40LG
14 optic nerve disease 30.4 CRP CD40LG CD4
15 multiple cranial nerve palsy 30.4 RHNO1 CRP
16 neuroretinitis 30.3 CRP CD40LG CD4
17 aortitis 30.3 CRP CD40LG
18 maxillary sinusitis 30.3 CRP CD40LG
19 splenic infarction 30.3 CRP CD40LG
20 cranial nerve palsy 30.3 RHNO1 CRP CD40LG CD4
21 orbital cellulitis 30.3 RHNO1 CRP
22 central retinal artery occlusion 30.2 RHNO1 CRP CD40LG
23 kawasaki disease 30.2 CRP CD40LG CD4
24 pericardial effusion 30.2 CRP CD40LG CD4
25 granulomatosis with polyangiitis 30.2 CRP CD40LG CD4
26 facial paralysis 30.2 CRP CD8A CD40LG CD4
27 chlamydia pneumonia 30.2 CRP CD40LG CD4
28 hypertensive retinopathy 30.2 CRP ATP6V1D
29 poliomyelitis 30.2 CD8A CD40LG CD4
30 chickenpox 30.2 CRP CD8A CD40LG CD4
31 chronic meningitis 30.2 CRP CD40LG CD4
32 syphilis 30.1 CRP CD8A CD40LG CD4
33 sphenoid sinusitis 30.1 RHNO1 KAT8
34 progressive multifocal leukoencephalopathy 30.1 CD8A CD40LG CD4
35 ethmoid sinusitis 30.1 RHNO1 CRP
36 epidural abscess 30.1 KAT8 CRP
37 exanthem 30.0 CRP CD8A CD40LG CD4
38 otitis externa 30.0 RHNO1 CRP
39 viral encephalitis 30.0 CD8A CD40LG CD4
40 dysentery 30.0 CRP CD40LG CD4
41 sarcoidosis 1 30.0 CRP CD8A CD40LG CD4
42 peripheral nervous system disease 30.0 CRP CD8A CD40LG CD4
43 mononeuritis multiplex 30.0 CRP CD40LG CD4
44 iridocyclitis 30.0 CRP CD40LG CD4
45 acute proliferative glomerulonephritis 30.0 CRP CD40LG CD4
46 kwashiorkor 29.9 CRP CD4
47 variola major 29.9 CD8A CD4
48 blastomycosis 29.9 CD8A CD40LG CD4
49 histoplasmosis 29.9 CD8A CD40LG CD4
50 herpes zoster 29.9 CRP CD8A CD40LG CD4

Graphical network of the top 20 diseases related to Cerebritis:



Diseases related to Cerebritis

Symptoms & Phenotypes for Cerebritis

Drugs & Therapeutics for Cerebritis

Drugs for Cerebritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
2
Valine Approved, Nutraceutical Phase 2 72-18-4 6287
3 Pharmaceutical Solutions Phase 2
4
Serine Investigational, Nutraceutical Phase 2 56-45-1 5951
5
Arginine Investigational, Nutraceutical Phase 2 74-79-3 6322

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Immune Ablation and Hematopoietic Stem Cell Support in Patients With Poor Prognostic Indicators and Systemic Lupus Erythematosus:A Phase II Study Completed NCT00271934 Phase 2
2 A Phase 2, Randomized, Double Blind, Placebo , Controlled Study To Evaluate The Administration of CN-105 In Participants With Acute Supratentorial Intracerebral Hemorrhage Not yet recruiting NCT03711903 Phase 2 Acetyl-Valine-Serine-Arginine-Arginine-Arginine-NH2 (Ac-VSRRR- NH2).;0.9% Sodium-chloride
3 A Pilot Study of Inpatient Hospice With Procurement of Brain Tumor Tissue on Expiration for Research Purposes Terminated NCT01251913

Search NIH Clinical Center for Cerebritis

Genetic Tests for Cerebritis

Anatomical Context for Cerebritis

MalaCards organs/tissues related to Cerebritis:

40
Brain, Heart, Bone, Thyroid, Kidney, T Cells, Pituitary

Publications for Cerebritis

Articles related to Cerebritis:

(show top 50) (show all 387)
# Title Authors PMID Year
1
Dual-Use Intraoperative MRI in Glioblastoma Surgery: Results of Resection, Histopathologic Assessment, and Surgical Site Infections. 61
31272122 2019
2
A case report of multiple cerebral abscess formation complicating serogroup B Neisseria meningitidis meningitis. 61
31638913 2019
3
Holohemispheric Invasive Aspergillus Granulomatous Cerebritis of the Brain. 61
31562969 2019
4
Comparison of CSF and MRI Findings among Neonates and Infants with E coli or Group B Streptococcal Meningitis. 61
31320464 2019
5
Suspected hematologic malignancy complicates lupus cerebritis treatment. 61
30913146 2019
6
Tocilizumab for the management of immune mediated adverse events secondary to PD-1 blockade. 61
29207939 2019
7
A versatile imaging platform with fluorescence and CT imaging capabilities that detects myeloperoxidase activity and inflammation at different scales. 61
31695784 2019
8
Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits. 61
30610193 2019
9
Fungal Rhino-orbital Cerebritis in a Patient with Steroid-induced Ketoacidosis. 61
30443618 2018
10
Fatal orbital cellulitis with intracranial complications: a case report. 61
31179919 2018
11
Fatal cryptococcal meningitis in an AIDS patient complicated with immune reconstitution syndrome refractory to prolonged amphotericin B treatment. 61
29749873 2018
12
Nanoscale mechanics of brain abscess: An atomic force microscopy study. 61
29957562 2018
13
Neuroinfections caused by fungi. 61
29785613 2018
14
Therapeutic plasma exchange for pediatric nonrenal disease indications and outcomes: A single-center experience. 61
30692797 2018
15
Nickel-Related Adverse Reactions in the Treatment of Cerebral Aneurysms: A Literature Review. 61
29684517 2018
16
Capnocytophaga canimorsus: An Emerging Pathogen in Immunocompetent Patients-Experience from an Emergency Department. 61
29523423 2018
17
Radiosurgery versus open surgery for mesial temporal lobe epilepsy: The randomized, controlled ROSE trial. 61
29600809 2018
18
Steroid-Induced Psychosis in the Pediatric Population: A New Case and Review of the Literature. 61
29638141 2018
19
Angiocentric lymph proliferative disorder (lymphomatoid granulomatosis) in a person with newly-diagnosed HIV infection: a case report. 61
29739366 2018
20
Simultaneous treatment of intracranial complications of paranasal sinusitis. 61
29536253 2018
21
Multiple cortical brain abscesses due to Listeria monocytogenes in an immunocompetent patient. 61
28849735 2018
22
Incidence and pattern of brain lesions in paediatric septic shock patients. 61
29293365 2018
23
Programmed Cell Death Ligand 1-Induced Coma From Diffuse Cerebritis. 61
29016224 2018
24
First Reported Case of Neuroleptospirosis Complicated With Anton's Syndrome. 61
30564184 2018
25
Nephritis, cerebritis, and myositis after adalimumab therapy in a patient with rheumatoid arthritis: a case report. 61
29692623 2018
26
The role of hydroxychloroquine in catastrophic antiphospholipid syndrome case: Series of two case reports and review of literature. 61
30046446 2018
27
Magnetic resonance imaging spectrum of intracranial tubercular lesions: one disease, many faces. 61
30800191 2018
28
Subdural empyema case report of a rare disease with a high mortality. 61
30442008 2018
29
An update on bacterial brain abscess in immunocompetent patients. 61
28501669 2017
30
A Pott's Puffy Tumor Associated with Epidural - Cutaneous Fistula and Epidural Abscess: Case Report. 61
28443599 2017
31
Neonatal cranial sonography: ultrasound findings in neonatal meningitis-a pictorial review. 61
28275563 2017
32
Expressive aphasia caused by Streptococcus intermedius brain abscess in an immunocompetent patient. 61
28176963 2017
33
A 54-year-old male with rapidly progressive neurologic syndrome: Clinicopathologic correlation of a rare diagnosis. 61
28195100 2017
34
Disseminated melioidosis in the head and neck. 61
28096229 2017
35
Antigen presentation for priming T cells in central system. 61
27903432 2017
36
Parasitic and fungal infections. 61
28987173 2017
37
Giant Recurrent Supratentorial Neurenteric Cyst As a Cause of Medically Refractory Epilepsy. 61
30047676 2016
38
Ischaemic stroke and Clostridium septicum sepsis and meningitis in a patient with occult colon carcinoma - a case report and review of the literature. 61
27881097 2016
39
Early cerebritis resulting in a first-time seizure in an otherwise healthy young man. 61
27840566 2016
40
Neurological sequelae of bacterial meningitis. 61
27105658 2016
41
From suspected Creutzfeldt-Jakob disease to confirmed histoplasma meningitis. 61
27389723 2016
42
Postneurosurgical Central Nervous System Infection Due to Enterococcus faecalis Successfully Treated With Intraventricular Vancomycin. 61
27226704 2016
43
Implant Site Infection and Bone Flap Osteomyelitis Associated with the NeuroPace Responsive Neurostimulation System. 61
26743382 2016
44
Pneumococcal meningitis: clinical-pathological correlations (MeninGene-Path). 61
27001057 2016
45
Mycoplasma pneumoniae, a trigger for Weston Hurst syndrome. 61
26819961 2016
46
A case report of racemose pattern of intracranial tuberculoma with brain stem and hypophyseal involvement developing paradoxically during treatment. 61
30460000 2016
47
Anti-MDA5 Antibody Dermatomyositis Overlap with Systemic Lupus Erythematosus: A Case Report and Review of the Literature. 61
28077979 2016
48
Fungal Infections of the Central Nervous System: A Pictorial Review. 61
27403402 2016
49
An unusual case of a brain abscess arising from an odontogenic infection. 61
25484130 2015
50
An unusual presentation of herpes simplex encephalitis with negative PCR. 61
26243746 2015

Variations for Cerebritis

Expression for Cerebritis

Search GEO for disease gene expression data for Cerebritis.

Pathways for Cerebritis

Pathways related to Cerebritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.49 CRP C5AR2 C5AR1
2
Show member pathways
11.26 CRP C5AR2 C5AR1
3 10.38 CD8A CD40LG CD4

GO Terms for Cerebritis

Biological processes related to Cerebritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.65 CXCL2 CD8A CD40LG CD4 C5AR1
2 inflammatory response GO:0006954 9.55 CXCL2 CRP CD40LG C5AR2 C5AR1
3 complement receptor mediated signaling pathway GO:0002430 9.32 C5AR2 C5AR1
4 regulation of interleukin-8 secretion GO:2000482 8.96 CRP C5AR2
5 complement component C5a signaling pathway GO:0038178 8.62 C5AR2 C5AR1

Molecular functions related to Cerebritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 complement component C5a receptor activity GO:0004878 8.62 C5AR2 C5AR1

Sources for Cerebritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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