MCID: CRB009
MIFTS: 39

Cerebritis

Categories: Neuronal diseases

Aliases & Classifications for Cerebritis

MalaCards integrated aliases for Cerebritis:

Name: Cerebritis 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:3431
NCIt 51 C27199
UMLS 74 C0742115

Summaries for Cerebritis

Disease Ontology : 12 A brain disease that is characterized by inflammation of the brain tissue occurring as a result of an underlying condition.

MalaCards based summary : Cerebritis is related to immunodysregulation, polyendocrinopathy, and enteropathy, x-linked and maxillary sinusitis. An important gene associated with Cerebritis is WAC (WW Domain Containing Adaptor With Coiled-Coil), and among its related pathways/superpathways are PKMTs methylate histone lysines and Lysine degradation. The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and bone.

Wikipedia : 77 Cerebritis is an infection of the brain that normally leads to the formation of an abscess within the... more...

Related Diseases for Cerebritis

Diseases related to Cerebritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2542)
# Related Disease Score Top Affiliating Genes
1 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 29.1 IRAK4 SETD2
2 maxillary sinusitis 28.4 IRAK4 RHNO1
3 cerebral palsy 12.7
4 cerebral amyloid angiopathy, cst3-related 12.6
5 cerebral cavernous malformations 12.6
6 cerebral amyloid angiopathy, app-related 12.6
7 cerebral palsy, ataxic, autosomal recessive 12.5
8 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 12.5
9 cerebral cavernous malformations 2 12.4
10 cerebral cavernous malformations 3 12.4
11 vasculopathy, retinal, with cerebral leukodystrophy 12.4
12 cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 12.4
13 dyskinetic cerebral palsy 12.4
14 cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome 12.4
15 transient cerebral ischemia 12.4
16 cerebral atherosclerosis 12.4
17 cerebral aneurysms 12.4
18 cerebral atrophy 12.4
19 spastic diplegia cerebral palsy 12.4
20 spastic cerebral palsy 12.4
21 cerebral cavernous malformation, familial 12.3
22 cerebral folate deficiency 12.3
23 cerebral amyloid angiopathy, itm2b-related, 1 12.3
24 cerebral palsy, spastic quadriplegic, 1 12.3
25 cerebral hypoxia 12.3
26 microcephaly, progressive, with seizures and cerebral and cerebellar atrophy 12.3
27 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2 12.3
28 childhood-onset cerebral x-linked adrenoleukodystrophy 12.3
29 cerebral amyloid angiopathy, itm2b-related, 2 12.3
30 cerebral ventricle cancer 12.3
31 cerebral creatine deficiency syndrome 3 12.3
32 reversible cerebral vasoconstriction syndrome 12.3
33 cerebral arteriosclerosis 12.3
34 cerebral palsy, spastic quadriplegic, 2 12.3
35 keratosis follicularis, dwarfism, and cerebral atrophy 12.3
36 hereditary cerebral amyloid angiopathy 12.3
37 cerebral palsy, spastic quadriplegic, 3 12.2
38 fibrosis, neurodegeneration, and cerebral angiomatosis 12.2
39 deafness, dystonia, and cerebral hypomyelination 12.2
40 cerebral creatine deficiency syndrome 1 12.2
41 mixed cerebral palsy 12.2
42 cerebral creatine deficiency syndrome 2 12.2
43 cerebral arteritis 12.2
44 middle cerebral artery infarction 12.2
45 neurodegeneration due to cerebral folate transport deficiency 12.1
46 cerebral artery occlusion 12.1
47 malaria 12.1
48 lymphedema and cerebral arteriovenous anomaly 12.1
49 spastic quadriplegia 12.1
50 posterior cerebral artery infarction 12.1

Graphical network of the top 20 diseases related to Cerebritis:



Diseases related to Cerebritis

Symptoms & Phenotypes for Cerebritis

Drugs & Therapeutics for Cerebritis

Drugs for Cerebritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
3
Epinephrine Approved, Vet_approved Phase 3 51-43-4 5816
4
Racepinephrine Approved Phase 3 329-65-7 838
5 Neurotransmitter Agents Phase 3
6 Adrenergic Agonists Phase 3
7 Gastrointestinal Agents Phase 3
8 Adrenergic alpha-Agonists Phase 3
9 Anti-Asthmatic Agents Phase 3
10 Epinephryl borate Phase 3
11 HIV Protease Inhibitors Phase 3
12 Adrenergic beta-Agonists Phase 3
13 Antineoplastic Agents, Hormonal Phase 3
14 Hormones Phase 3
15 Peripheral Nervous System Agents Phase 3
16
protease inhibitors Phase 3
17 Respiratory System Agents Phase 3
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
19 Antiemetics Phase 3
20 glucocorticoids Phase 3
21 Vasoconstrictor Agents Phase 3
22 Mydriatics Phase 3
23 Autonomic Agents Phase 3
24 Anti-Inflammatory Agents Phase 3
25 Sympathomimetics Phase 3
26 BB 1101 Phase 3
27 Adrenergic Agents Phase 3
28 Bronchodilator Agents Phase 3
29 Pharmaceutical Solutions Phase 3,Phase 2
30 Hormone Antagonists Phase 3
31
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
32
Serine Approved, Nutraceutical Phase 2 56-45-1 5951
33 Fibrinolytic Agents Phase 2
34 Plasminogen Phase 2
35 Tissue Plasminogen Activator Phase 2
36 arginine Phase 2
37 valine Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bronchiolitis in Infants Placebo Versus Dexamethasone Study Recruiting NCT03567473 Phase 3 Oral dexamethasone;Nebulized Epinephrine;Oral placebo;Nebulized normal saline
2 Minimally Invasive Surgery and rtPA for Intracerebral Hemorrhage Evacuation Completed NCT00224770 Phase 2 MIS+Cathflo Activase (drug)
3 Evaluation of CN-105 in Subject With Acute Supratentorial Intracerebral Hemorrhage Not yet recruiting NCT03711903 Phase 2 Acetyl-Valine-Serine-Arginine-Arginine-Arginine-NH2 (Ac-VSRRR- NH2).;0.9% Sodium-chloride
4 External Ventricular Drain Placement Stealth Study Recruiting NCT03696043 Not Applicable
5 A Pilot Study of Inpatient Hospice With Procurement of Brain Tumor Tissue on Expiration for Research Purposes Terminated NCT01251913

Search NIH Clinical Center for Cerebritis

Genetic Tests for Cerebritis

Anatomical Context for Cerebritis

MalaCards organs/tissues related to Cerebritis:

42
Brain, Heart, Bone, Liver, Pituitary, Thyroid, Kidney

Publications for Cerebritis

Articles related to Cerebritis:

(show top 50) (show all 93)
# Title Authors Year
1
Suspected hematologic malignancy complicates lupus cerebritis treatment. ( 30913146 )
2019
2
Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits. ( 30610193 )
2019
3
Fungal Rhino-orbital Cerebritis in a Patient with Steroid-induced Ketoacidosis. ( 30443618 )
2018
4
Nephritis, cerebritis, and myositis after adalimumab therapy in a patient with rheumatoid arthritis: a case report. ( 29692623 )
2018
5
Programmed Cell Death Ligand 1-Induced Coma From Diffuse Cerebritis. ( 29016224 )
2018
6
Early cerebritis resulting in a first-time seizure in an otherwise healthy young man. ( 27840566 )
2016
7
Pathogenesis, clinical course and neuro-radiological signs of Proprionibacterium acnes cerebritis: Case report and literature review. ( 25762004 )
2015
8
Pseudomonas aeruginosa retro-orbital abscess and cerebritis leading to a diagnosis of interleukin-1 receptor-associated kinase-4 deficiency. ( 24183992 )
2015
9
A case of systemic lupus erythematosus associated with longitudinal extensive transverse myelitis, cerebral neutrophilic vasculitis, and cerebritis. ( 25986355 )
2014
10
A presentation of cerebritis secondary to granulomatosis with polyangiitis (wegener). ( 24900930 )
2014
11
Two case reports indicating the dilemma in diagnosing lupus cerebritis. ( 24479062 )
2013
12
Cerebritis arising from acute sinusitis evolving into a large brain abscess. ( 23668876 )
2013
13
Delayed cerebritis after bilateral stereotactic implantation of globus pallidus interna electrodes for treatment of dystonia. ( 23378545 )
2013
14
Immunocompetent young man with cerebral abscess and cortical venous infarction mimicking cerebritis caused by Gemella morbillorum. ( 23355562 )
2013
15
Imaging of cerebritis, encephalitis, and brain abscess. ( 23122258 )
2012
16
Systemic lupus erythematosus (SLE) cerebritis versus Listeria monocytogenes meningoencephalitis in a patient with systemic lupus erythematosus on chronic corticosteroid therapy: the diagnostic importance of cerebrospinal fluid (CSF) of lactic acid levels. ( 22177759 )
2012
17
A rare case of neonatal sepsis/meningitis caused by Pasteurella multocida complicated with status epilepticus and focal cerebritis. ( 22423481 )
2011
18
Cerebral spinal fluid penetration of tigecycline in a patient with Acinetobacter baumannii cerebritis. ( 20179255 )
2010
19
Periodic lateralized epileptiform discharges in neuropsychiatric lupus: association with cerebritis in magnetic resonance imaging and resolution after intravenous immunoglobulin. ( 20133346 )
2010
20
Lupus cerebritis after visiting a tanning salon. ( 20001946 )
2009
21
Cerebritis: an unusual complication of Klebsiella pneumoniae. ( 19881180 )
2009
22
Lupus activation with cerebritis following pegylated interferon in a hemodialysis patient. ( 19776782 )
2009
23
Fatal cerebritis and brain abscesses following a nontraumatic subdural hematoma in a chronic hemodialyzed patient. ( 19090864 )
2008
24
Absence of functional alternative complement pathway alleviates lupus cerebritis. ( 17523212 )
2007
25
Perfusion MR imaging and proton MR spectroscopic imaging in differentiating necrotizing cerebritis from glioblastoma multiforme. ( 17275620 )
2007
26
Vibrio fluvialis hemorrhagic cellulitis and cerebritis. ( 15825019 )
2005
27
Complement-dependent apoptosis and inflammatory gene changes in murine lupus cerebritis. ( 16339572 )
2005
28
Moxifloxacin in experimental Streptococcus pneumoniae cerebritis and meningitis. ( 16159084 )
2005
29
Listeria monocytogenes skin infection with cerebritis and haemophagocytosis syndrome in a bone marrow transplant recipient. ( 15845437 )
2005
30
Lupus cerebritis and steroid psychosis in mixed connective tissue disorder. ( 15829147 )
2004
31
Successful treatment of disseminated cerebritis complicating methicillin-resistant Staphylococcus aureus Endocarditis unresponsive to vancomycin therapy with linezolid. ( 15119370 )
2004
32
Streptococcus constellatus causing myocardial abscess complicated by cerebritis. ( 15060690 )
2004
33
Administration of the soluble complement inhibitor, Crry-Ig, reduces inflammation and aquaporin 4 expression in lupus cerebritis. ( 14636948 )
2003
34
The efficacy of trovafloxacin versus ceftriaxone in the treatment of experimental brain abscess/cerebritis in the rat. ( 12888116 )
2003
35
Diffusion-weighted imaging of cerebritis. ( 12812934 )
2003
36
Lupus cerebritis: a case study. ( 12197258 )
2002
37
Non-serogroup O:1 Vibrio cholerae bacteremia and cerebritis. ( 11264049 )
2001
38
Ommaya-catheter-related Staphylococcus epidermidis cerebritis and recurrent bacteremia documented by molecular typing. ( 11152314 )
2000
39
Diffusion magnetic resonance imaging findings in cerebritis and brain abscesses in a patient with septic encephalopathy. ( 10787125 )
2000
40
Encephalitis, cerebritis, and brain abscess: pathophysiology and imaging findings. ( 10775955 )
2000
41
Fatal Chaetomium cerebritis in a bone marrow transplant patient. ( 10414510 )
1999
42
Toxoplasma infection in systemic lupus erythematosus mimicking lupus cerebritis. ( 10377932 )
1999
43
Successful treatment of systemic lupus erythematosus cerebritis with intravenous immunoglobulin. ( 10357127 )
1999
44
Invasive sinusitis and cerebritis due to Curvularia clavata in an immunocompetent adult. ( 10194103 )
1999
45
Effect of neutrophil depletion in acute cerebritis. ( 9748561 )
1998
46
Fusobacterial cerebritis and myelitis presenting as acute paraplegia in an elderly man with congenital heart disease. ( 9314475 )
1997
47
Nursing care of a patient with lupus cerebritis. ( 8949210 )
1996
48
Cerebritis due to Listeria monocytogenes: CT and MR findings. ( 8797977 )
1996
49
Necrotizing cerebritis in an allogeneic bone marrow transplant recipient due to Cladophialophora bantiana. ( 8727934 )
1996
50
Meningitis, vasculitis, and cerebritis caused by CNS histoplasmosis: radiologic-pathologic correlation. ( 8571874 )
1996

Variations for Cerebritis

Expression for Cerebritis

Search GEO for disease gene expression data for Cerebritis.

Pathways for Cerebritis

Pathways related to Cerebritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.11 SETD1A SETD2
2 10.39 SETD1A SETD2

GO Terms for Cerebritis

Cellular components related to Cerebritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromosome GO:0005694 8.8 RHNO1 SETD1A SETD2

Biological processes related to Cerebritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 methylation GO:0032259 9.16 SETD1A SETD2
2 cellular response to DNA damage stimulus GO:0006974 9.13 WAC SETD2 RHNO1
3 chromatin organization GO:0006325 8.8 SETD2 SETD1A WAC

Molecular functions related to Cerebritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 methyltransferase activity GO:0008168 8.96 SETD1A SETD2
2 histone-lysine N-methyltransferase activity GO:0018024 8.62 SETD1A SETD2

Sources for Cerebritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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