MCID: CRB009
MIFTS: 37

Cerebritis

Categories: Neuronal diseases

Aliases & Classifications for Cerebritis

MalaCards integrated aliases for Cerebritis:

Name: Cerebritis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3431
NCIt 50 C27199
UMLS 73 C0742115

Summaries for Cerebritis

Disease Ontology : 12 A brain disease that is characterized by inflammation of the brain tissue occurring as a result of an underlying condition.

MalaCards based summary : Cerebritis is related to immunodysregulation, polyendocrinopathy, and enteropathy, x-linked and cerebral palsy. An important gene associated with Cerebritis is WAC (WW Domain Containing Adaptor With Coiled-Coil), and among its related pathways/superpathways are Chromatin Regulation / Acetylation and PKMTs methylate histone lysines. The drugs Epinephrine and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and heart, and related phenotype is adipose tissue.

Wikipedia : 76 Cerebritis is an infection of the brain that normally leads to the formation of an abscess within the... more...

Related Diseases for Cerebritis

Diseases related to Cerebritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2333)
# Related Disease Score Top Affiliating Genes
1 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 28.8 IRAK4 SETD2
2 cerebral palsy 12.6
3 cerebral amyloid angiopathy, cst3-related 12.6
4 cerebral cavernous malformations 12.5
5 cerebral amyloid angiopathy, app-related 12.5
6 cerebral palsy, ataxic, autosomal recessive 12.5
7 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 12.4
8 cerebral cavernous malformations 2 12.4
9 cerebral cavernous malformations 3 12.4
10 vasculopathy, retinal, with cerebral leukodystrophy 12.4
11 cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 12.4
12 dyskinetic cerebral palsy 12.4
13 transient cerebral ischemia 12.3
14 cerebral atrophy 12.3
15 cerebral aneurysms 12.3
16 cerebral atherosclerosis 12.3
17 spastic cerebral palsy 12.3
18 spastic diplegia cerebral palsy 12.3
19 cerebral cavernous malformation, familial 12.3
20 cerebral folate deficiency 12.3
21 cerebral amyloid angiopathy, itm2b-related, 1 12.3
22 cerebral hypoxia 12.3
23 cerebral amyloid angiopathy, itm2b-related, 2 12.3
24 reversible cerebral vasoconstriction syndrome 12.3
25 childhood-onset cerebral x-linked adrenoleukodystrophy 12.3
26 cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome 12.3
27 cerebral arteriosclerosis 12.2
28 cerebral ventricle cancer 12.2
29 keratosis follicularis, dwarfism, and cerebral atrophy 12.2
30 hereditary cerebral amyloid angiopathy 12.2
31 cerebral palsy, spastic quadriplegic, 1 12.2
32 microcephaly, progressive, with seizures and cerebral and cerebellar atrophy 12.2
33 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2 12.2
34 cerebral creatine deficiency syndrome 3 12.2
35 cerebral palsy, spastic quadriplegic, 2 12.1
36 mixed cerebral palsy 12.1
37 cerebral creatine deficiency syndrome 1 12.1
38 cerebral arteritis 12.1
39 deafness, dystonia, and cerebral hypomyelination 12.1
40 cerebral creatine deficiency syndrome 2 12.1
41 neurodegeneration due to cerebral folate transport deficiency 12.1
42 middle cerebral artery infarction 12.1
43 cerebral palsy, spastic quadriplegic, 3 12.1
44 spastic quadriplegia 12.1
45 cerebral artery occlusion 12.1
46 lymphedema and cerebral arteriovenous anomaly 12.1
47 cerebral lymphoma 12.0
48 malaria 12.0
49 cerebral hemorrhage 12.0
50 cerebral palsy athetoid 12.0

Graphical network of the top 20 diseases related to Cerebritis:



Diseases related to Cerebritis

Symptoms & Phenotypes for Cerebritis

MGI Mouse Phenotypes related to Cerebritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 8.8 PRLR SETD1A SETD2

Drugs & Therapeutics for Cerebritis

Drugs for Cerebritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 3 51-43-4 5816
2
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
3
Racepinephrine Approved Phase 3 329-65-7 838
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
5 Anti-Asthmatic Agents Phase 3
6 Mydriatics Phase 3
7 Antineoplastic Agents, Hormonal Phase 3
8 Adrenergic beta-Agonists Phase 3
9 Anti-Inflammatory Agents Phase 3
10 Adrenergic Agents Phase 3
11 Neurotransmitter Agents Phase 3
12 Autonomic Agents Phase 3
13 Peripheral Nervous System Agents Phase 3
14 Sympathomimetics Phase 3
15 Respiratory System Agents Phase 3
16 Adrenergic alpha-Agonists Phase 3
17 Bronchodilator Agents Phase 3
18 Vasoconstrictor Agents Phase 3
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
20 Antiemetics Phase 3
21 Adrenergic Agonists Phase 3
22 HIV Protease Inhibitors Phase 3
23 Hormones Phase 3
24 BB 1101 Phase 3
25 Pharmaceutical Solutions Phase 3,Phase 2
26
protease inhibitors Phase 3
27 Hormone Antagonists Phase 3
28 Gastrointestinal Agents Phase 3
29 glucocorticoids Phase 3
30 Epinephryl borate Phase 3
31
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
32
Serine Approved, Nutraceutical Phase 2 56-45-1 5951
33 Plasminogen Phase 2
34 Tissue Plasminogen Activator Phase 2
35 Fibrinolytic Agents Phase 2
36 arginine Phase 2
37 valine Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bronchiolitis in Infants Placebo Versus Dexamethasone Study Recruiting NCT03567473 Phase 3 Oral dexamethasone;Nebulized Epinephrine;Oral placebo;Nebulized normal saline
2 Minimally Invasive Surgery and rtPA for Intracerebral Hemorrhage Evacuation Completed NCT00224770 Phase 2 MIS+Cathflo Activase (drug)
3 Evaluation of CN-105 in Subject With Acute Supratentorial Intracerebral Hemorrhage Not yet recruiting NCT03711903 Phase 2 Acetyl-Valine-Serine-Arginine-Arginine-Arginine-NH2 (Ac-VSRRR- NH2).;0.9% Sodium-chloride
4 External Ventricular Drain Placement Stealth Study Recruiting NCT03696043 Not Applicable
5 A Pilot Study of Inpatient Hospice With Procurement of Brain Tumor Tissue on Expiration for Research Purposes Terminated NCT01251913

Search NIH Clinical Center for Cerebritis

Genetic Tests for Cerebritis

Anatomical Context for Cerebritis

MalaCards organs/tissues related to Cerebritis:

41
Brain, Bone, Heart, Kidney, Liver, Thyroid, T Cells

Publications for Cerebritis

Articles related to Cerebritis:

(show top 50) (show all 91)
# Title Authors Year
1
Nephritis, cerebritis, and myositis after adalimumab therapy in a patient with rheumatoid arthritis: a case report. ( 29692623 )
2018
2
Programmed Cell Death Ligand 1-Induced Coma From Diffuse Cerebritis. ( 29016224 )
2018
3
Fungal Rhino-orbital Cerebritis in a Patient with Steroid-induced Ketoacidosis. ( 30443618 )
2018
4
Early cerebritis resulting in a first-time seizure in an otherwise healthy young man. ( 27840566 )
2016
5
Pathogenesis, clinical course and neuro-radiological signs of Proprionibacterium acnes cerebritis: Case report and literature review. ( 25762004 )
2015
6
A presentation of cerebritis secondary to granulomatosis with polyangiitis (wegener). ( 24900930 )
2014
7
A case of systemic lupus erythematosus associated with longitudinal extensive transverse myelitis, cerebral neutrophilic vasculitis, and cerebritis. ( 25986355 )
2014
8
Delayed cerebritis after bilateral stereotactic implantation of globus pallidus interna electrodes for treatment of dystonia. ( 23378545 )
2013
9
Immunocompetent young man with cerebral abscess and cortical venous infarction mimicking cerebritis caused by Gemella morbillorum. ( 23355562 )
2013
10
Two case reports indicating the dilemma in diagnosing lupus cerebritis. ( 24479062 )
2013
11
Pseudomonas aeruginosa retro-orbital abscess and cerebritis leading to a diagnosis of interleukin-1 receptor-associated kinase-4 deficiency. ( 24183992 )
2013
12
Cerebritis arising from acute sinusitis evolving into a large brain abscess. ( 23668876 )
2013
13
Imaging of cerebritis, encephalitis, and brain abscess. ( 23122258 )
2012
14
Systemic lupus erythematosus (SLE) cerebritis versus Listeria monocytogenes meningoencephalitis in a patient with systemic lupus erythematosus on chronic corticosteroid therapy: the diagnostic importance of cerebrospinal fluid (CSF) of lactic acid levels. ( 22177759 )
2012
15
A rare case of neonatal sepsis/meningitis caused by Pasteurella multocida complicated with status epilepticus and focal cerebritis. ( 22423481 )
2011
16
Cerebral spinal fluid penetration of tigecycline in a patient with Acinetobacter baumannii cerebritis. ( 20179255 )
2010
17
Periodic lateralized epileptiform discharges in neuropsychiatric lupus: association with cerebritis in magnetic resonance imaging and resolution after intravenous immunoglobulin. ( 20133346 )
2010
18
Lupus activation with cerebritis following pegylated interferon in a hemodialysis patient. ( 19776782 )
2009
19
Lupus cerebritis after visiting a tanning salon. ( 20001946 )
2009
20
Cerebritis: an unusual complication of Klebsiella pneumoniae. ( 19881180 )
2009
21
Fatal cerebritis and brain abscesses following a nontraumatic subdural hematoma in a chronic hemodialyzed patient. ( 19090864 )
2008
22
Perfusion MR imaging and proton MR spectroscopic imaging in differentiating necrotizing cerebritis from glioblastoma multiforme. ( 17275620 )
2007
23
Absence of functional alternative complement pathway alleviates lupus cerebritis. ( 17523212 )
2007
24
Complement-dependent apoptosis and inflammatory gene changes in murine lupus cerebritis. ( 16339572 )
2005
25
Moxifloxacin in experimental Streptococcus pneumoniae cerebritis and meningitis. ( 16159084 )
2005
26
Vibrio fluvialis hemorrhagic cellulitis and cerebritis. ( 15825019 )
2005
27
Listeria monocytogenes skin infection with cerebritis and haemophagocytosis syndrome in a bone marrow transplant recipient. ( 15845437 )
2005
28
Lupus cerebritis and steroid psychosis in mixed connective tissue disorder. ( 15829147 )
2004
29
Streptococcus constellatus causing myocardial abscess complicated by cerebritis. ( 15060690 )
2004
30
Successful treatment of disseminated cerebritis complicating methicillin-resistant Staphylococcus aureus Endocarditis unresponsive to vancomycin therapy with linezolid. ( 15119370 )
2004
31
The efficacy of trovafloxacin versus ceftriaxone in the treatment of experimental brain abscess/cerebritis in the rat. ( 12888116 )
2003
32
Administration of the soluble complement inhibitor, Crry-Ig, reduces inflammation and aquaporin 4 expression in lupus cerebritis. ( 14636948 )
2003
33
Diffusion-weighted imaging of cerebritis. ( 12812934 )
2003
34
Lupus cerebritis: a case study. ( 12197258 )
2002
35
Non-serogroup O:1 Vibrio cholerae bacteremia and cerebritis. ( 11264049 )
2001
36
Diffusion magnetic resonance imaging findings in cerebritis and brain abscesses in a patient with septic encephalopathy. ( 10787125 )
2000
37
Ommaya-catheter-related Staphylococcus epidermidis cerebritis and recurrent bacteremia documented by molecular typing. ( 11152314 )
2000
38
Encephalitis, cerebritis, and brain abscess: pathophysiology and imaging findings. ( 10775955 )
2000
39
Successful treatment of systemic lupus erythematosus cerebritis with intravenous immunoglobulin. ( 10357127 )
1999
40
Fatal Chaetomium cerebritis in a bone marrow transplant patient. ( 10414510 )
1999
41
Invasive sinusitis and cerebritis due to Curvularia clavata in an immunocompetent adult. ( 10194103 )
1999
42
Toxoplasma infection in systemic lupus erythematosus mimicking lupus cerebritis. ( 10377932 )
1999
43
Effect of neutrophil depletion in acute cerebritis. ( 9748561 )
1998
44
Fusobacterial cerebritis and myelitis presenting as acute paraplegia in an elderly man with congenital heart disease. ( 9314475 )
1997
45
Necrotizing cerebritis in an allogeneic bone marrow transplant recipient due to Cladophialophora bantiana. ( 8727934 )
1996
46
Nursing care of a patient with lupus cerebritis. ( 8949210 )
1996
47
Meningitis, vasculitis, and cerebritis caused by CNS histoplasmosis: radiologic-pathologic correlation. ( 8571874 )
1996
48
Cerebritis due to Listeria monocytogenes: CT and MR findings. ( 8797977 )
1996
49
Diagnosis of brainstem abscess in the cerebritis stage by magnetic resonance imaging--case report. ( 7477693 )
1995
50
Sjogren's cerebritis complicated by subarachnoid hemorrhage and bilateral superior cerebellar artery occlusion: case report. ( 7701423 )
1995

Variations for Cerebritis

Expression for Cerebritis

Search GEO for disease gene expression data for Cerebritis.

Pathways for Cerebritis

Pathways related to Cerebritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 SETD1A SETD2
2
Show member pathways
11.11 SETD1A SETD2
3 10.39 SETD1A SETD2

GO Terms for Cerebritis

Biological processes related to Cerebritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 methylation GO:0032259 8.96 SETD1A SETD2
2 chromatin organization GO:0006325 8.8 SETD1A SETD2 WAC

Molecular functions related to Cerebritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 methyltransferase activity GO:0008168 8.96 SETD1A SETD2
2 histone-lysine N-methyltransferase activity GO:0018024 8.62 SETD1A SETD2

Sources for Cerebritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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