MCID: CRB079
MIFTS: 35

Cerebrospinal Fluid Leak

Categories: Ear diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Cerebrospinal Fluid Leak

MalaCards integrated aliases for Cerebrospinal Fluid Leak:

Name: Cerebrospinal Fluid Leak 19 71 75 31
Spinal Cerebrospinal Fluid Leak 71
Cerebrospinal Fluid Rhinorrhea 71
Spinal Csf Leak 19
Csf Rhinorrhea 19
Csf Otorrhea 19
Csf Leak 19

Classifications:



External Ids:

ICD10 31 G96.0
UMLS 71 C0007815 C0023182 C2936821

Summaries for Cerebrospinal Fluid Leak

GARD: 19 It is a rare but very serious condition that requires rapid intervention. Symptoms include leak of clear fluid through the ear, inflammation of the membranes that cover the brain (meningitis), hearing loss, and seizures. The cause of a spinal fluid leak through the ear is a defect of the bone and meningeal layers covering the brain that separate the subarachnoid space of the brain from the middle ear and mastoid bone (located just behind the ear). The leaks occur after a surgery in the base of the skull, temporal bone fractures, congenital defects of the inner ear, trauma, or they may be spontaneous.

MalaCards based summary: Cerebrospinal Fluid Leak, also known as spinal cerebrospinal fluid leak, is related to spontaneous intracranial hypotension and intracranial hypotension, and has symptoms including vertigo, pain and seizures. An important gene associated with Cerebrospinal Fluid Leak is PTGDS (Prostaglandin D2 Synthase). The drugs Thrombin and Fibrin Tissue Adhesive have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and brain.

Wikipedia: 75 A cerebrospinal fluid leak (CSF leak or CSFL) is a medical condition where the cerebrospinal fluid (CSF)... more...

Related Diseases for Cerebrospinal Fluid Leak

Diseases related to Cerebrospinal Fluid Leak via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 238)
# Related Disease Score Top Affiliating Genes
1 spontaneous intracranial hypotension 11.9
2 intracranial hypotension 10.9
3 acoustic neuroma 10.7
4 intracranial hypertension 10.7
5 headache 10.7
6 neurilemmoma 10.7
7 intracranial hypertension, idiopathic 10.7
8 otorrhea 10.6
9 pituitary adenoma 10.6
10 meningitis 10.6
11 encephalocele 10.6
12 adenoma 10.6
13 neuroma 10.6
14 meningioma, familial 10.5
15 meningocele 10.5
16 hydrocephalus 10.5
17 meningoencephalocele 10.4
18 craniopharyngioma 10.4
19 spinal stenosis 10.4
20 bacterial meningitis 10.4
21 chordoma 10.3
22 central diabetes insipidus 10.3
23 gorham's disease 10.3
24 diabetes insipidus 10.3
25 pituitary tumors 10.3
26 apnea, obstructive sleep 10.3
27 cystic angiomatosis of bone, diffuse 10.3
28 body mass index quantitative trait locus 1 10.3
29 nasopharyngeal carcinoma 10.3
30 empty sella syndrome 10.3
31 rhinitis 10.3
32 chronic rhinitis 10.3
33 hypertension, essential 10.2
34 trigeminal neuralgia 10.2
35 ocular motor apraxia 10.2
36 allergic rhinitis 10.2
37 sleep apnea 10.2
38 spondylosis 10.2
39 spinal cord disease 10.2
40 radiculopathy 10.2
41 degenerative disc disease 10.2
42 papilloma 10.2
43 chiari malformation type i 10.1
44 ear malformation 10.1
45 spondylosis, cervical 10.1
46 neuraminidase deficiency 10.1
47 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 10.1
48 ossification of the posterior longitudinal ligament of spine 10.1
49 inguinal hernia 10.1
50 osteonecrosis 10.1

Graphical network of the top 20 diseases related to Cerebrospinal Fluid Leak:



Diseases related to Cerebrospinal Fluid Leak

Symptoms & Phenotypes for Cerebrospinal Fluid Leak

UMLS symptoms related to Cerebrospinal Fluid Leak:


vertigo; pain; seizures; meningism; reflex, abnormal; neurobehavioral manifestations; neuromuscular manifestations

Drugs & Therapeutics for Cerebrospinal Fluid Leak

Drugs for Cerebrospinal Fluid Leak (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational Phase 3
2 Fibrin Tissue Adhesive Phase 3
3 Hemostatics Phase 3
4 Coagulants Phase 3
5
Morphine Approved, Investigational 57-27-2 5288826
6
Norepinephrine Approved 51-41-2 439260
7
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
8
Tannic acid Approved 1401-55-4 16129878 16129778
9
Chitosan low molecular weight (20-200 mpa.s) Experimental 14257-69-3, 9012-76-4 441477 71853
10 Analgesics
11 Analgesics, Opioid
12 Narcotics
13 Antimetabolites
14 Hypolipidemic Agents
15 Anticholesteremic Agents
16 Lipid Regulating Agents
17 Chelating Agents

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 Sphenopalatine Ganglion Nerve Block for Postdural Puncture Headache in Obstetrics Withdrawn NCT03181464 Phase 4 Lidocaine 4%;Placebo
2 A Single-Blinded, Randomized, Controlled Study to Evaluate the Safety and Effectiveness of EVICEL® Fibrin Sealant (Human) Compared to a Hydrogel Sealant as an Adjunct to Sutured Dural Repair Completed NCT02457546 Phase 3
3 A Randomised Controlled Study to Evaluate the Efficacy and Safety of Fibrin Sealant, Vapour Heated, Solvent/Detergent Treated FS VH S/D 500 S-apr (Tisseel) Compared to DuraSeal Dural Sealant as an Adjunct to Sutured Dural Repair in Cranial Surgery. Completed NCT02891070 Phase 3 FS VH S/D 500 s-apr
4 TachoSil® Versus Current Practice in Dura Sealing Techniques for the Prevention of Post-operative Cerebrospinal Fluid (CSF) Leaks in Patients Undergoing Skull Base Surgery: An Open Label, Randomised, Controlled, Multi-centre, Parallel Group Efficacy and Safety Trial. Completed NCT01355627 Phase 3
5 A Prospective Randomized Controlled Study Evaluating the Safety and Efficacy of EVICEL® Used for Suture-Line Sealing in Dura-Mater Closure During Paediatric Neurosurgical Cranial Procedures Terminated NCT02309645 Phase 3
6 A Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for Treatment of Cerebrospinal Fluid Leaks in Spontaneous Intracranial Hypotension. Completed NCT03276975 Phase 2 TISSEEL
7 Pilot Study of Acetazolamide to Prevent Post Operative Cerebrospinal Fluid (CSF) Leak in Patients Undergoing Endoscopic Skull Base Surgery Withdrawn NCT04351061 Phase 2 Acetazolamide
8 Pilot Study of Acetazolamide to Prevent Post Operative Cerebrospinal Fluid (CSF) Leak in Patients Undergoing Endoscopic Skull Base Surgery Withdrawn NCT02902133 Phase 2 Acetazolamide
9 A Prospective, Multi-center, Randomized, Parallel-controlled Clinical Trial Evaluating the Efficacy and Safety of Lyoplant Onlay in Repairing Cerebral Dura Mater Unknown status NCT04490629
10 Flat Bed Rest vs. Immediate Mobilisation After Incidental Durotomy During Lumbar Spinal Surgery: A Prospective Randomised Trial Unknown status NCT02927782
11 International Opinion Study on Peri-operative Cerebrospinal Fluid Leaks Management After Endoscopic Skull Base Surgery Completed NCT04124523
12 A Prospective, Multi-Center, Randomized Controlled Study to Compare the Spinal Sealant System as an Adjunct to Sutured Dural Repair With Standard of Care Methods During Spinal Surgery Completed NCT00444067
13 Incidence of Post-Dural Puncture Headache Following Unintentional Dural Puncture: A Randomized Trial of Intrathecal Morphine Versus Saline Completed NCT01977898 Morphine;Saline
14 Chitosan Scaffold for Sellar Floor Repair in Endoscopic Endonasal Transsphenoidal Surgery Completed NCT03280849
15 A Prospective, Randomized, Controlled Multi-center Study of ArtiFascia® Dural Repair Patch Compared With Commercially Available Dural Substitutes- NEOART Study. Completed NCT04145544
16 Auftreten Von Okkultem Asymptomatischem Liqourverlust Nach Nebenhöhlenoperationen Eine Prospektive Kohortenstudie Completed NCT02382692
17 Evaluation of a Simulation Based Workshop to Enhance Learning of Insertion and Management of CSF Drainage Catheters in an Anesthesia Residency Program Completed NCT03545984
18 Post-market Clinical Data Collection Plan for the Biodesign® Dural and Duraplasty Grafts Completed NCT04057157
19 Single-arm, Open-label, Multicenter Study to Evaluate the Safety and Performance of Dura Sealant Patch in Reducing CSF Leakage Following Elective Cranial Surgery Completed NCT03566602
20 A Multi-Center, Randomized, Controlled, Trial of Cerebrospinal Fluid Drainage (CSFD) in Acute Spinal Cord Injury Completed NCT02495545
21 Evaluation of Outcomes Related to Cerebrospinal Fluid Drains Placed Either With or Without Fluoroscopic Guidance for Aortic Surgery Completed NCT04505423
22 A Prospective, Open, Multi-center, Single-arm Study of the Performance and Safety of I-020805 in the Prevention of Cerebrospinal Fluid Leakage Following Elective Cranial Surgery Completed NCT01295619
23 Outcome of the Endoscopic Repair of Frontal Sinus Cerebrospinal Fluid Leak Completed NCT05024643
24 VALUE OF RADIONUCLIDE CISTERNOGRAPHY IN PATIENTS WITH CEREBROSPINAL FLUID LEAK Completed NCT02876614
25 Cone Beam CT (CS 9300) for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower Dose Completed NCT01855425
26 Randomized, Two-arm, Multicenter Study to Evaluate the Safety and Efficacy of Dura Sealant Patch in Reducing CSF Leakage Following Elective Cranial Surgery Recruiting NCT04086550
27 A Multicenter, Retrospective, Post-Market Clinical Follow-Up Study to Evaluate the Performance and Safety of Suturable DuraGen™ Recruiting NCT04923867
28 Multimodal Sonographic Monitoring of Cerebral Perfusion, Ventricle Seize and Optic Nerve Diameter During Weaning of Cerebrospinal Fluid Drainage Catheters: a Single Centre Observational Trial Recruiting NCT02408757
29 Free Middle Turbinate Flap for Repair of Low Flow Cerebrospinal Fluid Leak Not yet recruiting NCT04784169
30 The Effect of an ASC-seeded Collagen Hydrogel on Cerebrospinal Fluid Leak Rates Following Skull Base Surgery Withdrawn NCT04503161
31 CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar Tap Withdrawn NCT01932255

Search NIH Clinical Center for Cerebrospinal Fluid Leak

Genetic Tests for Cerebrospinal Fluid Leak

Anatomical Context for Cerebrospinal Fluid Leak

Organs/tissues related to Cerebrospinal Fluid Leak:

MalaCards : Spinal Cord, Bone, Brain, Pituitary, Temporal Lobe, Dorsal Root Ganglion, Caudate Nucleus

Publications for Cerebrospinal Fluid Leak

Articles related to Cerebrospinal Fluid Leak:

(show top 50) (show all 5047)
# Title Authors PMID Year
1
Invasive Pneumococcal Disease in High-risk Children: A 10-Year Retrospective Study. 62
36450100 2023
2
Risk Factors in a Pediatric Population for Postoperative Intracranial Infection Following Endoscopic Endonasal Skull Base Surgery and the Role of Antibiotic Prophylaxis. 62
36050937 2023
3
Cerebrospinal Fluid Leaks, Spontaneous Intracranial Hypotension, and Chiari I Malformation. 62
36424060 2023
4
"The Up and Down Approach" to Localize and Exclude Sites of Intraspinal CSF Leaks. 62
36123203 2023
5
The efficacy and safety of intrathecal fluorescein in endoscopic cerebrospinal fluid leak repair -a systematic review. 62
35393153 2022
6
Dural Sealants Do Not Reduce Postoperative Cerebrospinal Fluid Leak after Endoscopic Endonasal Skull Base Surgery. 62
36393876 2022
7
Coexistence of flavum ligament ossification with diffuse idiopathic skeletal hyperostosis in the cervical spine: Review of literature and technical note starting from a rare case. 62
36087693 2022
8
A simple surgical technique for sellar closure after transsphenoidal resection of pituitary adenomas in the context of risk factors for cerebrospinal fluid leaks and meningitis. 62
36455277 2022
9
Retrospective Review of Surgical Site Infections after Endoscopic Endonasal Sellar and Parasellar Surgery: Multicenter Quality Data from the North American Skull Base Society. 62
36393885 2022
10
Outcomes of endoscopic endonasal resection of pediatric craniopharyngiomas. 62
35485414 2022
11
Endoscopic Repair of Round Window Cochleocele. 62
36156534 2022
12
Infrapedicular approach to CT-guided thermal ablation in the thoracic spine. 62
35574645 2022
13
Endoscopic pituitary surgery: National database review. 62
36039744 2022
14
Incidence and Management of Facial Paralysis After Skull Base Trauma, an Administrative Database Study. 62
36214506 2022
15
A phase 1/2a dose-escalation study of oligodendrocyte progenitor cells in individuals with subacute cervical spinal cord injury. 62
35901693 2022
16
Growing fat tissue after grafting for dural sealing. 62
36436776 2022
17
Chiari Type III : Experience of Outcome for 15 Cases. 62
36281538 2022
18
Pediatric basilar skull fractures from multi-level falls: A systematic review and retrospective analysis. 62
36030630 2022
19
Incidental Durotomy Repair in Lumbar Spine Surgery: Institutional Experience and Review of Literature. 62
36426799 2022
20
Endoscopic Treatment of Rathke's Cleft Cysts: The Case for Simple Fenestration. 62
36358408 2022
21
SNOT-22 Quality of Life Scores Improve After Endoscopic Endonasal Repair of Spontaneous Cerebrospinal Fluid Rhinorrhea. 62
36377064 2022
22
Impact of surgical factors on delayed hyponatremia in patients with nonfunctioning pituitary adenoma after endonasal endoscopic transsphenoidal procedure. 62
35984619 2022
23
Starting point for benchmarking outcomes and reporting of pituitary adenoma surgery within the European Reference Network on Rare Endocrine Conditions (Endo-ERN): results from a meta-analysis and survey study. 62
36327151 2022
24
Microvascular Reconstruction of the Anterior Skull Base. 62
35984035 2022
25
Cerebrospinal Fluid Otorrhea After a Routine Tympanostomy Tube Placement: A Review of the Literature on Hyrtl Fissure. 62
36345799 2022
26
Combined transnasal/transoral endoscopic odontoid resection in pediatric patients: Otolaryngologic considerations to airway management, endoscopic exposure, and complication management. 62
36402000 2022
27
Novel use of nonpenetrating titanium clips for pediatric primary spinal dural closure: A technical note. 62
36084429 2022
28
Anterior and Lateral Skull Base Spontaneous CSF Leaks: Evaluation of Comorbidities and Treatment Outcomes. 62
36377071 2022
29
Minimally invasive endoscopic approaches to pediatric skull base pathologies. 62
36206699 2022
30
Risk Factors for Postoperative Cerebrospinal Fluid Leak after Graded Multilayer Cranial Base Repair with Suturing via the Endoscopic Endonasal Approach. 62
36436977 2022
31
Case report: Meningoencephalocele and recurrent bacterial meningitis in chronic idiopathic intracranial hypertension. 62
36368955 2022
32
Expanding the clinical spectrum of idiopathic intracranial hypertension. 62
36444979 2022
33
Neuroimaging in the diagnosis and treatment of intracranial pressure disorders. 62
36333629 2022
34
Spontaneous intracranial hypotension: updates from diagnosis to treatment. 62
36336758 2022
35
Transosseous Reconstruction of the Myofascial Layer After Suboccipital Craniotomy to Reduce the Rate of Pseudomeningocele Formation and Cerebrospinal Fluid Leak: A Technical Note. 62
36396054 2022
36
Delayed Cerebrospinal Fluid Leaks Complicating Endoscopic Orbital Surgeries. 62
36372926 2022
37
Direct Anterior Repair of Spontaneous Ventral Cervical Cerebrospinal Fluid Leak: 2-Dimensional Operative Video. 62
36374029 2022
38
Imaging, Clinical, and Demographic Differences in Patients With Type III Spinal Cerebrospinal Fluid Leak (Cerebrospinal Venous Fistulas) Compared With Patients With Types I and II Spinal Cerebrospinal Fluid Leak. 62
36112050 2022
39
CSF Flow and Spinal Cord Motion in Patients With Spontaneous Intracranial Hypotension: A Phase Contrast MRI Study. 62
36357188 2022
40
Case report: Recurrent spontaneous cerebrospinal fluid (CSF) leak. 62
36334550 2022
41
Comparison of Graft Materials in Multilayer Reconstruction with Nasoseptal Flap for High-Flow CSF Leak during Endoscopic Skull Base Surgery. 62
36431187 2022
42
CSF leak complicating the infralabyrinthine approach to petrous apex: lessons learnt. 62
36414351 2022
43
Systematic Review: Evaluating the Efficacy of Intrathecal Fluorescein for Localizing Cerebrospinal Fluid Rhinorrhea. 62
36409876 2022
44
[Diagnostic value of computed tomographic cisternography and magnetic resonance hydrography in cerebrospinal fluid rhinorrhea]. 62
36347580 2022
45
Phase Contrast Spine MRI for the Evaluation of CSF Leak, and Why It Matters. 62
36357186 2022
46
Investigating acetazolamide effectiveness on CSF leak in adult patients after spinal surgery. 62
35811251 2022
47
Treatment Patterns and Health Care Resource Utilization of Iatrogenic Spinal Cerebrospinal Fluid Leaks in the United States. 62
35858207 2022
48
Management of Traumatic and Non-Traumatic Cerebrospinal Fluid Rhinorrhea-Experience from Three Southeast Asian Countries. 62
36360727 2022
49
Endoscopic Endonasal Transsphenoidal Approach to Repair Cerebrospinal Fluid Rhinorrhea After an Anterior Clinoidectomy for Aneurysm Clipping: Series of 4 Cases. 62
36227187 2022
50
Surgical Site Infection in the Intensive Care Setting After Posterior Spinal Fusion: A Case Series Highlighting the Microbial Profile, Risk Factors, and the Importance of Comorbid Disease Burden. 62
36103357 2022

Variations for Cerebrospinal Fluid Leak

Expression for Cerebrospinal Fluid Leak

Search GEO for disease gene expression data for Cerebrospinal Fluid Leak.

Pathways for Cerebrospinal Fluid Leak

GO Terms for Cerebrospinal Fluid Leak

Sources for Cerebrospinal Fluid Leak

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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