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MCID: CRB079
MIFTS: 38

Cerebrospinal Fluid Leak

Categories: Rare diseases, Neuronal diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Cerebrospinal Fluid Leak

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MalaCards integrated aliases for Cerebrospinal Fluid Leak:

Name: Cerebrospinal Fluid Leak 53 73
Spinal Cerebrospinal Fluid Leak 73
Cerebrospinal Fluid Rhinorrhea 73
Spinal Csf Leak 53
Csf Rhinorrhea 53
Csf Otorrhea 53
Csf Leak 53

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

ICD10 33 G96.0
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Summaries for Cerebrospinal Fluid Leak

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NIH Rare Diseases : 53 Cerebrospinal fluid (CSF) otorrhea is the leakage of cerebrospinal fluid (CSF) though the ear. It is a rare but very serious condition that requires rapid intervention. Symptoms include leak of clear fluid through the ear, inflammation of the membranes that cover the brain (meningitis), hearing loss, and seizures. The cause of a spinal fluid leak through the ear is a defect of the bone and meningeal layers covering the brain that separate the subarachnoid space of the brain from the middle ear and mastoid bone (located just behind the ear). The leaks occur after a surgery in the base of the skull, temporal bone fractures, congenital defects of the inner ear, trauma, or they may be spontaneous. Treatment depends on the cause and may include antibiotics, compression dressing and surgery. 

MalaCards based summary : Cerebrospinal Fluid Leak, also known as spinal cerebrospinal fluid leak, is related to spontaneous intracranial hypotension and intracranial hypotension, and has symptoms including meningism, pain and reflex, abnormal. An important gene associated with Cerebrospinal Fluid Leak is PTGDS (Prostaglandin D2 Synthase). The drugs Thrombin and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and pituitary.

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Related Diseases for Cerebrospinal Fluid Leak

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Diseases related to Cerebrospinal Fluid Leak via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 spontaneous intracranial hypotension 12.3
2 intracranial hypotension 11.5
3 cervicitis 10.4
4 headache 10.4
5 acoustic neuroma 10.3
6 neuroma 10.3
7 meningitis 10.3
8 intracranial hypertension 10.3
9 encephalocele 10.2
10 body mass index quantitative trait locus 1 10.0
11 pituitary adenoma 10.0
12 adenoma 10.0
13 meningoencephalocele 10.0
14 allergic rhinitis 9.9
15 meningocele 9.9
16 rhinitis 9.9
17 decubitus ulcer 9.9
18 glioma susceptibility 1 9.8
19 neural tube defects 9.8
20 lung cancer 9.8
21 dandy-walker syndrome 9.8
22 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 9.8
23 breast reconstruction 9.8
24 spinal stenosis 9.8
25 myelomeningocele 9.8
26 mucositis 9.8
27 osteomyelitis 9.8
28 intracranial aneurysm 9.8
29 esophagitis 9.8
30 vaginitis 9.8
31 glioblastoma multiforme 9.8
32 oligodendroglioma 9.8
33 cerebellopontine angle tumor 9.8
34 cerebritis 9.8
35 empty sella syndrome 9.8
36 craniopharyngioma 9.8
37 hidrocystoma 9.8
38 radiculopathy 9.8
39 pneumonia 9.8
40 paraplegia 9.8
41 suprasellar meningioma 9.8
42 mediastinitis 9.8
43 ependymoma 9.8
44 glioblastoma 9.8
45 oligoastrocytoma 9.8
46 tethered cord syndrome 9.8
47 fibromyalgia 9.8
48 aneurysm 9.8
49 dysphagia 9.8
50 encephalopathy 9.8

Graphical network of the top 20 diseases related to Cerebrospinal Fluid Leak:



Diseases related to Cerebrospinal Fluid Leak
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Symptoms & Phenotypes for Cerebrospinal Fluid Leak

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UMLS symptoms related to Cerebrospinal Fluid Leak:


meningism, pain, reflex, abnormal, seizures, vertigo, neurobehavioral manifestations, neuromuscular manifestations
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Drugs & Therapeutics for Cerebrospinal Fluid Leak

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Drugs for Cerebrospinal Fluid Leak (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 94)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational Phase 4,Phase 3,Phase 2
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
4 Anesthetics Phase 4,Phase 2,Not Applicable
5 Fibrin Tissue Adhesive Phase 4,Phase 3,Phase 2,Not Applicable
6 Coagulants Phase 4,Phase 3,Phase 2,Not Applicable
7 Hemostatics Phase 4,Phase 3,Phase 2,Not Applicable
8 Anesthetics, Local Phase 4,Not Applicable
9 Peripheral Nervous System Agents Phase 4,Not Applicable
10 Pharmaceutical Solutions Phase 4,Phase 3
11 Sodium Channel Blockers Phase 4
12 Diuretics, Potassium Sparing Phase 4
13 Anti-Arrhythmia Agents Phase 4
14
Loperamide Approved Phase 3 53179-11-6 3955
15 Gastrointestinal Agents Phase 3
16 Antidiarrheals Phase 3
17 Antisecretory factor Phase 3
18
Acetazolamide Approved, Vet_approved Phase 2,Not Applicable 59-66-5 1986
19
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
20
Aminolevulinic acid Approved Phase 2 106-60-5 137
21
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
22
Probenecid Approved, Investigational Phase 1, Phase 2 57-66-9 4911
23
Acetylcysteine Approved, Investigational Phase 1, Phase 2 616-91-1 12035
24
Carmustine Approved, Investigational Phase 2 154-93-8 2578
25
Norepinephrine Approved Phase 2 51-41-2 439260
26
Benzocaine Approved, Investigational Phase 2 1994-09-7, 94-09-7 2337
27
Serine Approved, Nutraceutical Phase 2 56-45-1 5951
28 tannic acid Approved, Nutraceutical Phase 2
29
Levulinic acid Experimental Phase 2 123-76-2 11579
30 diuretics Phase 2,Not Applicable
31 Adjuvants, Anesthesia Phase 2
32 GABA Agents Phase 2
33 GABA Modulators Phase 2
34 Natriuretic Agents Phase 2,Not Applicable
35 Neurotransmitter Agents Phase 2
36 Anesthetics, General Phase 2,Not Applicable
37 Anesthetics, Intravenous Phase 2,Not Applicable
38 Tranquilizing Agents Phase 2
39 Anti-Anxiety Agents Phase 2
40 Hypnotics and Sedatives Phase 2,Not Applicable
41 Anticonvulsants Phase 2,Not Applicable
42 Psychotropic Drugs Phase 2
43 Carbonic Anhydrase Inhibitors Phase 2,Not Applicable
44 Alkylating Agents Phase 2
45
protease inhibitors Phase 2
46 Renal Agents Phase 1, Phase 2
47 Respiratory System Agents Phase 1, Phase 2
48 Serine Proteinase Inhibitors Phase 2
49 Heptavalent Pneumococcal Conjugate Vaccine Phase 2
50 HIV Protease Inhibitors Phase 2

Interventional clinical trials:

(show top 50) (show all 65)
# Name Status NCT ID Phase Drugs
1 Efficacy of Tachosil as Dural Sealant Compared to Standard Treatment Completed NCT00999999 Phase 4
2 The Paediatric EVICEL® Neuro Study Recruiting NCT02309645 Phase 4
3 Sphenopalatine Ganglion Nerve Block for Postdural Puncture Headache in Obstetrics Recruiting NCT03181464 Phase 4 Lidocaine 4%;Placebo
4 TASALL - TachoSil® Against Liquor Leak Completed NCT01355627 Phase 3
5 The EVICEL® Neurosurgery Phase III Study Completed NCT02457546 Phase 3
6 A Study to Evaluate the Safety and Effectiveness of EVICEL as an Adjunct to Sutured Dural Repair Completed NCT01174992 Phase 2, Phase 3
7 Safety and Effectiveness of the Adherus Dural Sealant System When Used as a Dural Sealant in Cranial Procedures Completed NCT01158378 Phase 3
8 Efficacy and Safety of FS VH S/D 500 S-apr as an Adjunct to Sutured Dural Repair in Cranial Surgery Recruiting NCT02891070 Phase 3 FS VH S/D 500 s-apr
9 Bioseal Dural Sealing Study BIOS-14-001 Recruiting NCT03110783 Phase 3
10 Effect of Antisecretory Factor, Given as a Food Supplement to Adult Patients With Severe Traumatic Brain Injury Recruiting NCT03339505 Phase 3
11 The Tilburg Vasospasm Study Terminated NCT01407614 Phase 2, Phase 3
12 Effect of Acetazolamide & Position in CSF Leakage and Collection and Wound Dehiscence Unknown status NCT01867268 Phase 2 Acetazolamide
13 Bedside Sedation for the Prevention of Post Dural Puncture Headache Unknown status NCT01503788 Phase 2 Midazolam
14 Fibrin Sealant for the Sealing of Dura Sutures Completed NCT00681824 Phase 2
15 Overcoming Membrane Transporters to Improve CNS Drug Delivery - Improving Brain Antioxidants After Traumatic Brain Injury Completed NCT01322009 Phase 1, Phase 2 Probenecid and N-acetyl cysteine;Placebo
16 Lumbar Drainage in Subarachnoid Haemorrhage Completed NCT00842049 Phase 2
17 Gliadel Wafer and Fluorescence-Guided Surgery With 5-ALA Followed by Radiation Therapy And Temozolomide in Treating Patients With Primary Glioblastoma Completed NCT01310868 Phase 2 5-ALA;Gliadel wafers;Concomitant chemotherapy as normal based on standard clinical protocols determined by the neuro-oncologist;Adjuvant chemotherapy as normal based on standard clinical protocols determined by the neuro-oncologist
18 Pneumococci and Hib Vaccination After Neurotrauma or Neurosurgery Completed NCT02806284 Phase 2
19 A Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for Treatment Recruiting NCT03276975 Phase 2 TISSEEL
20 Cerebrospinal Fluid Drainage (CSFD) in Acute Spinal Cord Injury Recruiting NCT02495545 Phase 2
21 A Clinical Trial for Treatment of Aromatic L-amino Acid Decarboxylase (AADC) Deficiency Using AAV2-hAADC - An Expansion Recruiting NCT02926066 Phase 2 AAV2-hAADC
22 A Phase I/II Clinical Trial for Treatment of Aromatic L-amino Acid Decarboxylase (AADC) Deficiency Using AAV2-hAADC Active, not recruiting NCT01395641 Phase 1, Phase 2 gene therapy
23 Mobilisation Algorithm After Incidental Durotomy Unknown status NCT02927782 Not Applicable
24 Study to Evaluate the Safety and Efficacy of Dural Repair Patch in Neurosurgical Repairs Unknown status NCT02129114 Not Applicable
25 Chiari Study Looking at Use of Duragen Versus Duraguard Unknown status NCT00565435
26 Value of Radionuclide Cisternography Completed NCT02876614
27 Performance and Safety of I-020805 in Prevention of Cerebrospinal Fluid (CSF) Leakage Following Elective Craniotomy Completed NCT01295619 Not Applicable
28 A New Cochlear Implant Electrode For Inner Ear Malformations Completed NCT02011867 Not Applicable
29 Study to Evaluate Safety & Effectiveness of Spinal Sealant Completed NCT00444067 Not Applicable
30 Cerebrospinal Fluid Rhinorrhea After Functional Endoscopic Sinus Surgery Completed NCT02382692
31 Monitoring Patient Cerebro-Spinal Fluid Drainage With an Ultrasonic Flow Sensor Completed NCT00652197
32 DuraSeal Exact Spine Sealant System Post-Approval Study Completed NCT01410864
33 Chitosan Scaffold for Sellar Floor Repair in Endoscopic Endonasal Transsphenoidal Surgery Completed NCT03280849 Not Applicable
34 A Comparison Between Two Techniques for Performing Decompressive Craniectomy Completed NCT02594137 Not Applicable
35 Estimating EC95 of Remifentanil for Cough Prevention During Emergence From Total Intravenous Anesthesia With Propofol and Remifentanil in Patients Undergoing Transsphenoidal Hypophysectomy Completed NCT01735019 Not Applicable Administration of remifentanil with TCI system
36 Body Mass Index and Post-dural Puncture Headache Completed NCT02999919 Not Applicable
37 Study of Shunt Flow Sensor Accuracy in Extra-ventricular Drains. Completed NCT01108965
38 Alteration in Hearing Following Accidental Dural Puncture. A Study in Parturients Completed NCT01682967
39 DuraSeal Sealant Post Market Study Completed NCT00704340 Not Applicable
40 Influence of Drainage on EVD ICP-signal Completed NCT03164434
41 Olfactory Dysfunction of Rhinosinusitis - Cyclic Adenosine Monophosphate (cAMP)/Calcium Signaling Study Completed NCT00970190
42 Sonographic Monitoring of Weaning of Cerebrospinal Fluid Drainages Recruiting NCT02408757
43 Incidence of Headache Following an Unintentional Dural Puncture Recruiting NCT01977898 Not Applicable Morphine;Saline
44 Effects on the Awakening With Laryngeal Mask vs Endotracheal Tube in Endoscopic Endonasal Transsphenoidal Base Surgery Recruiting NCT02988804 Not Applicable
45 Impact of Herniation on WFNS Grading in Spontaneous Subarachnoid Hemorrhage - a SWISS SOS Observational Trial Recruiting NCT02304328
46 Prediction of Post-dural Puncture Headache in Parturients Undergoing Elective Caesarean Section Recruiting NCT03464253
47 Auditory Brainstem Implant (ABI) in Pediatric Non-Neurofibromatosis Type 2 Subjects Recruiting NCT01864291 Not Applicable
48 Utilization of iMRI for Transsphenoidal Resection of Pituitary Macroadenomas Recruiting NCT02396810 Not Applicable
49 Primary Tumor Research and Outcome Network Recruiting NCT02790983
50 Computer Based Algorithm for Patient Specific Implants for Cranioplasty in Patients With Skull Defects Recruiting NCT02828306

Search NIH Clinical Center for Cerebrospinal Fluid Leak

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Genetic Tests for Cerebrospinal Fluid Leak

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Anatomical Context for Cerebrospinal Fluid Leak

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MalaCards organs/tissues related to Cerebrospinal Fluid Leak:

41
Bone, Brain, Pituitary, Spinal Cord, Testes, Breast, Colon
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Publications for Cerebrospinal Fluid Leak

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Articles related to Cerebrospinal Fluid Leak:

(show top 50) (show all 355)
# Title Authors Year
1
Cerebrospinal fluid leak after bone marrow biopsy. ( 29048111 )
2018
2
Corrigendum to "Paradoxical postural cerebrospinal fluid leak-induced headache: Report of two cases" [J Clin Anesth 20 (5) (2008 Aug) 383-5]. ( 29980004 )
2018
3
Horizontal lateral lamella as a risk factor for iatrogenic cerebrospinal fluid leak. Clinical retrospective evaluation of 24 cases. ( 29785412 )
2018
4
Multifaceted Adjunct for Prevention of Cerebrospinal Fluid Leak Following External Ventricular Drain Placement To Minimize Incidence of Infection. ( 29232806 )
2018
5
Posttraumatic cerebrospinal fluid leak associated with an upper cervical meningeal diverticulum. ( 29777885 )
2018
6
Excellent outcomes of large-volume epidural blood patch using an intravenous catheter in 15 consecutive cases with cerebrospinal fluid leak. ( 29966793 )
2018
7
Penetrating trauma causing cerebrospinal fluid leak without nerve root damage. ( 29764819 )
2018
8
Cerebrospinal Fluid Leak at Percutaneous Exit of Ventricular Catheter as a Crucial Risk Factor for External Ventricular Drainage-Related Infection in Adult Neurosurgical Patients. ( 28989043 )
2018
9
Surgical outcomes in the treatment of temporal bone cerebrospinal fluid leak: A systematic review. ( 29636204 )
2018
10
The Management of Cerebrospinal Fluid Leak After Anterior Cervical Decompression Surgery. ( 29451938 )
2018
11
Meningoencephalocele and Cerebrospinal Fluid Leak Complicating Orbital Decompression. ( 29342033 )
2018
12
Tailored Strategies to Manage Cerebrospinal Fluid Leaks or Pseudomeningocele After Surgery for Tethered Cord Syndrome. ( 29605699 )
2018
13
Combined Endoscopic Transorbital and Endonasal Repair of High Flow Orbital Apex/Middle Fossa Cerebrospinal Fluid Leak with a Nasoseptal Flap. ( 29676403 )
2018
14
Management of a posterior gunshot injury with a floating pedicle and cerebrospinal fluid leak. ( 29525911 )
2018
15
The Surgical Treatment of Posttraumatic Skull Base Defects with Cerebrospinal Fluid Leak. ( 29868329 )
2018
16
Lumbar Drains Decrease the Risk of Postoperative Cerebrospinal Fluid Leak Following Endonasal Endoscopic Surgery for Suprasellar Meningiomas in Patients With High Body Mass Index. ( 29253284 )
2018
17
Risk factors for cerebrospinal fluid leak in pediatric patients undergoing endoscopic endonasal skull base surgery. ( 28109490 )
2017
18
Cerebrospinal Fluid Leak Rhinorrhea after Systemic Erlotinib Chemotherapy for Metastatic Lung Cancer: A Familiar Problem from an Unfamiliar Culprit. ( 28887281 )
2017
19
Can the Risks of Cerebrospinal Fluid Leak After Vestibular Schwannoma Surgery Be Predicted? ( 27851657 )
2017
20
Diagnosis and Management of Cerebrospinal Fluid Leak in a Panfacial Fracture. ( 28872498 )
2017
21
Spinal Cord Herniation After Cervical Corpectomy with Cerebrospinal Fluid Leak: Case Report and Review of the Literature. ( 28159690 )
2017
22
Spontaneous cerebrospinal fluid leak from the optic canal. ( 29276604 )
2017
23
Endonasal endoscopic management of frontal sinus cerebrospinal fluid leak. ( 29122086 )
2017
24
Risk factors associated with postoperative cerebrospinal fluid leak after endoscopic endonasal skull base surgery. ( 28598276 )
2017
25
Recurrent meningitis with unusually delayed cerebrospinal fluid leak detected by magnetic resonance cisternography. ( 28084280 )
2017
26
Endoscopic Endonasal Cerebrospinal Fluid Leak Repair on the Ventral Midline Skull Base: A Single Neurosurgical Center Experience. ( 28481397 )
2017
27
Locating the site of cerebrospinal fluid leak in a patient with low cerebrospinal fluid pressure. ( 28427771 )
2017
28
Reconstructive outcome of intraoperative cerebrospinal fluid leak after endoscopic endonasal surgery for tumors involving skull base. ( 28765065 )
2017
29
Vaginal Migration of Ventriculoperitoneal Shunt Catheter and Cerebrospinal Fluid Leak as a Complication of Hysterectomy. ( 28461282 )
2017
30
Cranio-cervical junction cerebrospinal fluid leak after microdebrider-assisted adenoidectomy - A rare case report. ( 28802733 )
2017
31
Management of a Ventral Cerebrospinal Fluid Leak With a Lumbar Transforaminal Epidural Blood Patch in a Child With Persistent Postdural Puncture Headache: A Case Report. ( 28178090 )
2017
32
Efficacy of intraoperative lumbar subarachnoid drainage for prevention of cerebrospinal fluid leak after spinal cord tumor resection. ( 29191390 )
2017
33
Treatment of cerebrospinal fluid leak after spine surgery. ( 28336418 )
2017
34
Traumatic Cerebrospinal Fluid Leak: Diagnosis and Management. ( 29201836 )
2017
35
Efficacy of Perioperative Lumbar Drainage following Endonasal Endoscopic Cerebrospinal Fluid Leak Repair. ( 27677601 )
2017
36
Cost Analysis of Cerebrospinal Fluid Leaks and Cerebrospinal Fluid Leak Prevention in Patients Undergoing Cerebellopontine Angle Surgery. ( 27779560 )
2017
37
Canalis basalis medianus with cerebrospinal fluid leak: rare presentation and literature review. ( 28660774 )
2017
38
Cerebrospinal fluid leak during stapes surgery: Gushing leaks and oozing leaks, two different phenomena. ( 28846785 )
2017
39
Epidural cerebrospinal fluid leak: A rare cause of upper limb amyotrophy - A report of two cases. ( 27695253 )
2016
40
Body mass index and the risk of postoperative cerebrospinal fluid leak following trans-sphenoidal surgery in an Asian population. ( 27653546 )
2016
41
The role of ICP monitoring in patients with persistent cerebrospinal fluid leak following spinal surgery: a case series. ( 27393191 )
2016
42
Endoscopic Transmaxillary Transposition of Temporalis Flap for Recurrent Cerebrospinal Fluid Leak Closure. ( 27857869 )
2016
43
Spontaneous Cerebrospinal Fluid Leak With Venous Engorgement Mimicking a Contrast-Enhancing Cervical Mass. ( 27243137 )
2016
44
The use of intrathecal fluorescein in cerebrospinal fluid leak repair: management from an anesthesiologist's point-of-view. ( 27401542 )
2016
45
The Relief of Unilateral Painful Thoracic Radiculopathy without Headache from Remote Spontaneous Spinal Cerebrospinal Fluid Leak. ( 27445613 )
2016
46
A new multilayer reconstruction using nasal septal flap combined with fascia graft dural suturing for high-flow cerebrospinal fluid leak after endoscopic endonasal surgery. ( 26886779 )
2016
47
Postoperative Cerebrospinal Fluid Leak Rates with Subfascial Epidural Drain Placement after Intentional Durotomy in Spine Surgery. ( 27853662 )
2016
48
Spontaneous cerebrospinal fluid leak from an anomalous thoracic nerve root: case report. ( 27367938 )
2016
49
Factors impacting cerebrospinal fluid leak rates in endoscopic sellar surgery. ( 27552303 )
2016
50
Management of Cerebrospinal Fluid Leak following Posterior Cranial Fossa Surgery. ( 28083041 )
2016
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Variations for Cerebrospinal Fluid Leak

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Expression for Cerebrospinal Fluid Leak

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Search GEO for disease gene expression data for Cerebrospinal Fluid Leak.
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Pathways for Cerebrospinal Fluid Leak

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GO Terms for Cerebrospinal Fluid Leak

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Cellular components related to Cerebrospinal Fluid Leak according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perinuclear region of cytoplasm GO:0048471 8.62 PTGDS TPPP3
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Sources for Cerebrospinal Fluid Leak

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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