MCID: CRB079
MIFTS: 37

Cerebrospinal Fluid Leak

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Cerebrospinal Fluid Leak

MalaCards integrated aliases for Cerebrospinal Fluid Leak:

Name: Cerebrospinal Fluid Leak 53 73
Spinal Cerebrospinal Fluid Leak 73
Cerebrospinal Fluid Rhinorrhea 73
Spinal Csf Leak 53
Csf Rhinorrhea 53
Csf Otorrhea 53
Csf Leak 53

Classifications:



External Ids:

ICD10 33 G96.0

Summaries for Cerebrospinal Fluid Leak

NIH Rare Diseases : 53 Cerebrospinal fluid (CSF) otorrhea is the leakage of cerebrospinal fluid (CSF) though the ear. It is a rare but very serious condition that requires rapid intervention. Symptoms include leak of clear fluid through the ear, inflammation of the membranes that cover the brain (meningitis), hearing loss, and seizures. The cause of a spinal fluid leak through the ear is a defect of the bone and meningeal layers covering the brain that separate the subarachnoid space of the brain from the middle ear and mastoid bone (located just behind the ear). The leaks occur after a surgery in the base of the skull, temporal bone fractures, congenital defects of the inner ear, trauma, or they may be spontaneous. Treatment depends on the cause and may include antibiotics, compression dressing and surgery. 

MalaCards based summary : Cerebrospinal Fluid Leak, also known as spinal cerebrospinal fluid leak, is related to spontaneous intracranial hypotension and intracranial hypotension, and has symptoms including seizures, vertigo and pain. An important gene associated with Cerebrospinal Fluid Leak is PTGDS (Prostaglandin D2 Synthase). The drugs Thrombin and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and pituitary.

Related Diseases for Cerebrospinal Fluid Leak

Diseases related to Cerebrospinal Fluid Leak via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 spontaneous intracranial hypotension 12.5
2 intracranial hypotension 11.6
3 headache 10.5
4 acoustic neuroma 10.4
5 neuroma 10.4
6 meningitis 10.4
7 intracranial hypertension 10.4
8 encephalocele 10.2
9 body mass index quantitative trait locus 1 10.1
10 pituitary adenoma 10.1
11 adenoma 10.1
12 allergic rhinitis 10.0
13 rhinitis 10.0
14 decubitus ulcer 10.0
15 meningoencephalocele 10.0
16 ear malformation 10.0
17 lymphangiomatosis 10.0
18 hydrocephalus due to congenital stenosis of aqueduct of sylvius 9.9
19 papilloma of choroid plexus 9.9
20 pituitary adenoma, prolactin-secreting 9.9
21 papilloma 9.9
22 arachnoid cysts 9.9
23 perilymphatic fistula 9.9
24 glioma susceptibility 1 9.9
25 neural tube defects 9.9
26 lung cancer 9.9
27 dandy-walker syndrome 9.9
28 ocular motor apraxia 9.9
29 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 9.9
30 breast reconstruction 9.9
31 spinal stenosis 9.9
32 myelomeningocele 9.9
33 osteomyelitis 9.9
34 meningocele 9.9
35 intracranial aneurysm 9.9
36 glioblastoma multiforme 9.9
37 oligodendroglioma 9.9
38 cerebellopontine angle tumor 9.9
39 empty sella syndrome 9.9
40 hidrocystoma 9.9
41 radiculopathy 9.9
42 gorham's disease 9.9
43 paraplegia 9.9
44 bacterial meningitis 9.9
45 ependymoma 9.9
46 glioblastoma 9.9
47 oligoastrocytoma 9.9
48 tethered cord syndrome 9.9
49 fibromyalgia 9.9
50 pituitary tumors 9.9

Graphical network of the top 20 diseases related to Cerebrospinal Fluid Leak:



Diseases related to Cerebrospinal Fluid Leak

Symptoms & Phenotypes for Cerebrospinal Fluid Leak

UMLS symptoms related to Cerebrospinal Fluid Leak:


seizures, vertigo, pain, meningism, reflex, abnormal, neurobehavioral manifestations, neuromuscular manifestations

Drugs & Therapeutics for Cerebrospinal Fluid Leak

Drugs for Cerebrospinal Fluid Leak (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 97)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational Phase 4,Phase 3,Phase 2
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
4 Anesthetics Phase 4,Phase 2,Not Applicable
5 Pharmaceutical Solutions Phase 4,Phase 3
6 Coagulants Phase 4,Phase 3,Phase 2,Not Applicable
7 Fibrin Tissue Adhesive Phase 4,Phase 3,Phase 2,Not Applicable
8 Hemostatics Phase 4,Phase 3,Phase 2,Not Applicable
9 Anesthetics, Local Phase 4,Not Applicable
10 Peripheral Nervous System Agents Phase 4,Not Applicable
11 Anti-Arrhythmia Agents Phase 4
12 Diuretics, Potassium Sparing Phase 4
13 Sodium Channel Blockers Phase 4
14
Loperamide Approved Phase 3 53179-11-6 3955
15 Antidiarrheals Phase 3
16 Gastrointestinal Agents Phase 3
17 Antisecretory factor Phase 3
18
Acetazolamide Approved, Vet_approved Phase 2,Not Applicable 59-66-5 1986
19
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
20
Probenecid Approved, Investigational Phase 1, Phase 2 57-66-9 4911
21
Acetylcysteine Approved, Investigational Phase 1, Phase 2 616-91-1 12035
22
Aminolevulinic acid Approved Phase 2 106-60-5 137
23
Carmustine Approved, Investigational Phase 2 154-93-8 2578
24
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
25
Benzocaine Approved, Investigational Phase 2 94-09-7, 1994-09-7 2337
26
Norepinephrine Approved Phase 2 51-41-2 439260
27 tannic acid Approved Phase 2
28
Serine Approved, Nutraceutical Phase 2 56-45-1 5951
29
Levulinic acid Experimental Phase 2 123-76-2 11579
30 diuretics Phase 2,Not Applicable
31 Natriuretic Agents Phase 2,Not Applicable
32 Carbonic Anhydrase Inhibitors Phase 2,Not Applicable
33 Anticonvulsants Phase 2,Not Applicable
34 Anesthetics, General Phase 2,Not Applicable
35 GABA Modulators Phase 2
36 Anesthetics, Intravenous Phase 2,Not Applicable
37 GABA Agents Phase 2
38 Neurotransmitter Agents Phase 2
39 Tranquilizing Agents Phase 2
40 Anti-Anxiety Agents Phase 2
41 Adjuvants, Anesthesia Phase 2
42 Psychotropic Drugs Phase 2
43 Hypnotics and Sedatives Phase 2,Not Applicable
44 Antiparkinson Agents Phase 2,Phase 1
45 Dopa Decarboxylase Phase 2,Phase 1
46 Dihydroxyphenylalanine Phase 2,Phase 1
47 Trypsin Inhibitors Phase 2
48 HIV Protease Inhibitors Phase 2
49
protease inhibitors Phase 2
50 Serine Proteinase Inhibitors Phase 2

Interventional clinical trials:

(show top 50) (show all 69)
# Name Status NCT ID Phase Drugs
1 Efficacy of Tachosil as Dural Sealant Compared to Standard Treatment Completed NCT00999999 Phase 4
2 The Paediatric EVICEL® Neuro Study Recruiting NCT02309645 Phase 4
3 Sphenopalatine Ganglion Nerve Block for Postdural Puncture Headache in Obstetrics Not yet recruiting NCT03181464 Phase 4 Lidocaine 4%;Placebo
4 The EVICEL® Neurosurgery Phase III Study Completed NCT02457546 Phase 3
5 TASALL - TachoSil® Against Liquor Leak Completed NCT01355627 Phase 3
6 Efficacy and Safety of FS VH S/D 500 S-apr (Tisseel) as an Adjunct to Sutured Dural Repair in Cranial Surgery Completed NCT02891070 Phase 3 FS VH S/D 500 s-apr
7 A Study to Evaluate the Safety and Effectiveness of EVICEL as an Adjunct to Sutured Dural Repair Completed NCT01174992 Phase 2, Phase 3
8 Safety and Effectiveness of the Adherus Dural Sealant System When Used as a Dural Sealant in Cranial Procedures Completed NCT01158378 Phase 3
9 Bioseal Dural Sealing Study BIOS-14-001 Recruiting NCT03110783 Phase 3
10 Effect of Antisecretory Factor, Given as a Food Supplement to Adult Patients With Severe Traumatic Brain Injury Recruiting NCT03339505 Phase 3
11 The Tilburg Vasospasm Study Terminated NCT01407614 Phase 2, Phase 3
12 Effect of Acetazolamide & Position in CSF Leakage and Collection and Wound Dehiscence Unknown status NCT01867268 Phase 2 Acetazolamide
13 Bedside Sedation for the Prevention of Post Dural Puncture Headache Unknown status NCT01503788 Phase 2 Midazolam
14 A Clinical Trial for Treatment of Aromatic L-amino Acid Decarboxylase (AADC) Deficiency Using AAV2-hAADC - An Expansion Unknown status NCT02926066 Phase 2 AAV2-hAADC
15 Fibrin Sealant for the Sealing of Dura Sutures Completed NCT00681824 Phase 2
16 Overcoming Membrane Transporters to Improve CNS Drug Delivery - Improving Brain Antioxidants After Traumatic Brain Injury Completed NCT01322009 Phase 1, Phase 2 Probenecid and N-acetyl cysteine;Placebo
17 Lumbar Drainage in Subarachnoid Haemorrhage Completed NCT00842049 Phase 2
18 Gliadel Wafer and Fluorescence-Guided Surgery With 5-ALA Followed by Radiation Therapy And Temozolomide in Treating Patients With Primary Glioblastoma Completed NCT01310868 Phase 2 5-ALA;Gliadel wafers;Concomitant chemotherapy as normal based on standard clinical protocols determined by the neuro-oncologist;Adjuvant chemotherapy as normal based on standard clinical protocols determined by the neuro-oncologist
19 Pneumococci and Hib Vaccination After Neurotrauma or Neurosurgery Completed NCT02806284 Phase 2
20 A Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for Treatment Recruiting NCT03276975 Phase 2 TISSEEL
21 Cerebrospinal Fluid Drainage (CSFD) in Acute Spinal Cord Injury Recruiting NCT02495545 Phase 2
22 A Phase I/II Clinical Trial for Treatment of Aromatic L-amino Acid Decarboxylase (AADC) Deficiency Using AAV2-hAADC Active, not recruiting NCT01395641 Phase 1, Phase 2 gene therapy
23 Patch vs. No Patch Fetoscopic Meningomyelocele Repair Study Recruiting NCT03794011 Phase 1
24 Mobilisation Algorithm After Incidental Durotomy Unknown status NCT02927782 Not Applicable
25 Study to Evaluate the Safety and Efficacy of Dural Repair Patch in Neurosurgical Repairs Unknown status NCT02129114 Not Applicable
26 Chiari Study Looking at Use of Duragen Versus Duraguard Unknown status NCT00565435
27 Value of Radionuclide Cisternography Completed NCT02876614
28 Performance and Safety of I-020805 in Prevention of Cerebrospinal Fluid (CSF) Leakage Following Elective Craniotomy Completed NCT01295619 Not Applicable
29 A New Cochlear Implant Electrode For Inner Ear Malformations Completed NCT02011867 Not Applicable
30 Study to Evaluate Safety & Effectiveness of Spinal Sealant Completed NCT00444067 Not Applicable
31 Monitoring Patient Cerebro-Spinal Fluid Drainage With an Ultrasonic Flow Sensor Completed NCT00652197
32 Cerebrospinal Fluid Rhinorrhea After Functional Endoscopic Sinus Surgery Completed NCT02382692
33 DuraSeal Exact Spine Sealant System Post-Approval Study Completed NCT01410864
34 Chitosan Scaffold for Sellar Floor Repair in Endoscopic Endonasal Transsphenoidal Surgery Completed NCT03280849 Not Applicable
35 A Comparison Between Two Techniques for Performing Decompressive Craniectomy Completed NCT02594137 Not Applicable
36 Estimating EC95 of Remifentanil for Cough Prevention During Emergence From Total Intravenous Anesthesia With Propofol and Remifentanil in Patients Undergoing Transsphenoidal Hypophysectomy Completed NCT01735019 Not Applicable Administration of remifentanil with TCI system
37 Body Mass Index and Post-dural Puncture Headache Completed NCT02999919 Not Applicable
38 Study of Shunt Flow Sensor Accuracy in Extra-ventricular Drains. Completed NCT01108965
39 Alteration in Hearing Following Accidental Dural Puncture. A Study in Parturients Completed NCT01682967
40 DuraSeal Sealant Post Market Study Completed NCT00704340 Not Applicable
41 Influence of Drainage on EVD ICP-signal Completed NCT03164434
42 Prediction of Post-dural Puncture Headache in Parturients Undergoing Elective Caesarean Section Completed NCT03464253
43 Olfactory Dysfunction of Rhinosinusitis - Cyclic Adenosine Monophosphate (cAMP)/Calcium Signaling Study Completed NCT00970190
44 Sonographic Monitoring of Weaning of Cerebrospinal Fluid Drainages Recruiting NCT02408757
45 L-PRF in Cranial Surgery Recruiting NCT03812120 Not Applicable
46 Incidence of Headache Following an Unintentional Dural Puncture Recruiting NCT01977898 Not Applicable Morphine;Saline
47 Effects on the Awakening With Laryngeal Mask vs Endotracheal Tube in Endoscopic Endonasal Transsphenoidal Base Surgery Recruiting NCT02988804 Not Applicable
48 Impact of Herniation on WFNS Grading in Spontaneous Subarachnoid Hemorrhage - a SWISS SOS Observational Trial Recruiting NCT02304328
49 Utilization of iMRI for Transsphenoidal Resection of Pituitary Macroadenomas Recruiting NCT02396810 Not Applicable
50 Primary Tumor Research and Outcome Network Recruiting NCT02790983

Search NIH Clinical Center for Cerebrospinal Fluid Leak

Genetic Tests for Cerebrospinal Fluid Leak

Anatomical Context for Cerebrospinal Fluid Leak

MalaCards organs/tissues related to Cerebrospinal Fluid Leak:

41
Bone, Brain, Pituitary, Spinal Cord, Testes, Lung, Breast

Publications for Cerebrospinal Fluid Leak

Articles related to Cerebrospinal Fluid Leak:

(show top 50) (show all 355)
# Title Authors Year
1
Management of spontaneous temporal bone cerebrospinal fluid leak: A 30-year experience. ( 30472121 )
2019
2
Cerebrospinal fluid leak after bone marrow biopsy. ( 29048111 )
2018
3
Corrigendum to "Paradoxical postural cerebrospinal fluid leak-induced headache: Report of two cases" [J Clin Anesth 20 (5) (2008 Aug) 383-5]. ( 29980004 )
2018
4
Horizontal lateral lamella as a risk factor for iatrogenic cerebrospinal fluid leak. Clinical retrospective evaluation of 24 cases. ( 29785412 )
2018
5
Multifaceted Adjunct for Prevention of Cerebrospinal Fluid Leak Following External Ventricular Drain Placement To Minimize Incidence of Infection. ( 29232806 )
2018
6
Posttraumatic cerebrospinal fluid leak associated with an upper cervical meningeal diverticulum. ( 29777885 )
2018
7
Excellent outcomes of large-volume epidural blood patch using an intravenous catheter in 15 consecutive cases with cerebrospinal fluid leak. ( 29966793 )
2018
8
Penetrating trauma causing cerebrospinal fluid leak without nerve root damage. ( 29764819 )
2018
9
Cerebrospinal Fluid Leak at Percutaneous Exit of Ventricular Catheter as a Crucial Risk Factor for External Ventricular Drainage-Related Infection in Adult Neurosurgical Patients. ( 28989043 )
2018
10
Surgical outcomes in the treatment of temporal bone cerebrospinal fluid leak: A systematic review. ( 29636204 )
2018
11
The Management of Cerebrospinal Fluid Leak After Anterior Cervical Decompression Surgery. ( 29451938 )
2018
12
Meningoencephalocele and Cerebrospinal Fluid Leak Complicating Orbital Decompression. ( 29342033 )
2018
13
Combined Endoscopic Transorbital and Endonasal Repair of High Flow Orbital Apex/Middle Fossa Cerebrospinal Fluid Leak with a Nasoseptal Flap. ( 29676403 )
2018
14
Management of a posterior gunshot injury with a floating pedicle and cerebrospinal fluid leak. ( 29525911 )
2018
15
The Surgical Treatment of Posttraumatic Skull Base Defects with Cerebrospinal Fluid Leak. ( 29868329 )
2018
16
Expert's comment concerning Grand Rounds case entitled "Management of a posterior gunshot injury with a floating pedicle and cerebrospinal fluid leak" by A. Bourghli, S. Abouhashem, R. Abo Wali, I. Obeid, L. Boissiere, J. M. Vital, M. Al Sarawan (Eur Spine J; 2018. DOI 10.1007/s00586-018-5537-9). ( 29623493 )
2018
17
Lumbar Drains Decrease the Risk of Postoperative Cerebrospinal Fluid Leak Following Endonasal Endoscopic Surgery for Suprasellar Meningiomas in Patients With High Body Mass Index. ( 29253284 )
2018
18
Corrigendum to "Reconstructive outcome of intraoperative cerebrospinal fluid leak after endoscopic endonasal surgery for tumors involving skull base" [J. Clin. Neurosci. 45 (2017) 227-231]. ( 30287251 )
2018
19
Disturbed Consciousness and Coma: Diagnosis and Management of Intracranial Hypotension Caused by a Spinal Cerebrospinal Fluid Leak. ( 30292664 )
2018
20
Unilateral rhinorrhoea associated with cerebrospinal fluid leak. ( 30301833 )
2018
21
Repair of Cerebrospinal Fluid Leak in Cochlear Implantation. ( 30339594 )
2018
22
The Effect of lumbar drains on spontaneous cerebrospinal fluid leak repair. ( 30351284 )
2018
23
Risk Factors for Cerebrospinal Fluid Leak Following Anterior Cervical Discectomy and Fusion. ( 30379657 )
2018
24
Erratum to "Surgical outcomes in the treatment of temporal bone cerebrospinal fluid leak: A systematic review" [Auris Nasus Larynx 45 (2018) 903-910]. ( 30472083 )
2018
25
Does lumbar drainage reduce postoperative cerebrospinal fluid leak after endoscopic endonasal skull base surgery? A prospective, randomized controlled trial. ( 30485224 )
2018
26
Intraoperative Cerebrospinal Fluid Leak in Extradural Spinal Tumor Surgery. ( 30531655 )
2018
27
Cerebrospinal Fluid Leak in Juvenile Nasopharyngeal Angiofibroma-Rare Sequelae of Flutamide-Induced Tumor Shrinkage. ( 30099189 )
2018
28
An Endoscopic Endonasal Repair of Spontaneous Skull Base Cerebrospinal Fluid Leak. ( 30110523 )
2018
29
Visualized ethmoid roof cerebrospinal fluid leak during frontal balloon sinuplasty. ( 30138524 )
2018
30
Cerebrospinal Fluid Leak and Symptomatic Pseudomeningocele After Intradural Spine Surgery. ( 30149160 )
2018
31
Fluoroscopy-Assisted Transnasal Onyx Occlusion of the Eustachian Tube for Lateral Skull Base Cerebrospinal Fluid Leak Repair. ( 30210977 )
2018
32
Risk factors for cerebrospinal fluid leak in pediatric patients undergoing endoscopic endonasal skull base surgery. ( 28109490 )
2017
33
Cerebrospinal Fluid Leak Rhinorrhea after Systemic Erlotinib Chemotherapy for Metastatic Lung Cancer: A Familiar Problem from an Unfamiliar Culprit. ( 28887281 )
2017
34
Can the Risks of Cerebrospinal Fluid Leak After Vestibular Schwannoma Surgery Be Predicted? ( 27851657 )
2017
35
Diagnosis and Management of Cerebrospinal Fluid Leak in a Panfacial Fracture. ( 28872498 )
2017
36
Spinal Cord Herniation After Cervical Corpectomy with Cerebrospinal Fluid Leak: Case Report and Review of the Literature. ( 28159690 )
2017
37
Spontaneous cerebrospinal fluid leak from the optic canal. ( 29276604 )
2017
38
Endonasal endoscopic management of frontal sinus cerebrospinal fluid leak. ( 29122086 )
2017
39
Risk factors associated with postoperative cerebrospinal fluid leak after endoscopic endonasal skull base surgery. ( 28598276 )
2017
40
Recurrent meningitis with unusually delayed cerebrospinal fluid leak detected by magnetic resonance cisternography. ( 28084280 )
2017
41
Endoscopic Endonasal Cerebrospinal Fluid Leak Repair on the Ventral Midline Skull Base: A Single Neurosurgical Center Experience. ( 28481397 )
2017
42
Locating the site of cerebrospinal fluid leak in a patient with low cerebrospinal fluid pressure. ( 28427771 )
2017
43
Reconstructive outcome of intraoperative cerebrospinal fluid leak after endoscopic endonasal surgery for tumors involving skull base. ( 28765065 )
2017
44
Vaginal Migration of Ventriculoperitoneal Shunt Catheter and Cerebrospinal Fluid Leak as a Complication of Hysterectomy. ( 28461282 )
2017
45
Cranio-cervical junction cerebrospinal fluid leak after microdebrider-assisted adenoidectomy - A rare case report. ( 28802733 )
2017
46
Management of a Ventral Cerebrospinal Fluid Leak With a Lumbar Transforaminal Epidural Blood Patch in a Child With Persistent Postdural Puncture Headache: A Case Report. ( 28178090 )
2017
47
Efficacy of intraoperative lumbar subarachnoid drainage for prevention of cerebrospinal fluid leak after spinal cord tumor resection. ( 29191390 )
2017
48
Treatment of cerebrospinal fluid leak after spine surgery. ( 28336418 )
2017
49
Traumatic Cerebrospinal Fluid Leak: Diagnosis and Management. ( 29201836 )
2017
50
Efficacy of Perioperative Lumbar Drainage following Endonasal Endoscopic Cerebrospinal Fluid Leak Repair. ( 27677601 )
2017

Variations for Cerebrospinal Fluid Leak

Expression for Cerebrospinal Fluid Leak

Search GEO for disease gene expression data for Cerebrospinal Fluid Leak.

Pathways for Cerebrospinal Fluid Leak

GO Terms for Cerebrospinal Fluid Leak

Cellular components related to Cerebrospinal Fluid Leak according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perinuclear region of cytoplasm GO:0048471 8.62 PTGDS TPPP3

Sources for Cerebrospinal Fluid Leak

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....