MCID: CRB079
MIFTS: 36

Cerebrospinal Fluid Leak

Categories: Ear diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Cerebrospinal Fluid Leak

MalaCards integrated aliases for Cerebrospinal Fluid Leak:

Name: Cerebrospinal Fluid Leak 20 70 32
Spinal Cerebrospinal Fluid Leak 70
Cerebrospinal Fluid Rhinorrhea 70
Spinal Csf Leak 20
Csf Rhinorrhea 20
Csf Otorrhea 20
Csf Leak 20

Classifications:



External Ids:

ICD10 32 G96.0
UMLS 70 C0007815 C0023182 C2936821

Summaries for Cerebrospinal Fluid Leak

GARD : 20 Cerebrospinal fluid (CSF) otorrhea is the leakage of cerebrospinal fluid (CSF) though the ear. It is a rare but very serious condition that requires rapid intervention. Symptoms include leak of clear fluid through the ear, inflammation of the membranes that cover the brain ( meningitis ), hearing loss, and seizures. The cause of a spinal fluid leak through the ear is a defect of the bone and meningeal layers covering the brain that separate the subarachnoid space of the brain from the middle ear and mastoid bone (located just behind the ear). The leaks occur after a surgery in the base of the skull, temporal bone fractures, congenital defects of the inner ear, trauma, or they may be spontaneous. Treatment depends on the cause and may include antibiotics, compression dressing and surgery.

MalaCards based summary : Cerebrospinal Fluid Leak, also known as spinal cerebrospinal fluid leak, is related to spontaneous intracranial hypotension and intracranial hypotension, and has symptoms including seizures, vertigo and pain. An important gene associated with Cerebrospinal Fluid Leak is PTGDS (Prostaglandin D2 Synthase). The drugs Thrombin and Hemostatics have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and bone.

Wikipedia : 73 A cerebrospinal fluid leak (CSF leak) is a medical condition where the cerebrospinal fluid (CSF)... more...

Related Diseases for Cerebrospinal Fluid Leak

Diseases related to Cerebrospinal Fluid Leak via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)
# Related Disease Score Top Affiliating Genes
1 spontaneous intracranial hypotension 11.8
2 intracranial hypotension 10.8
3 headache 10.7
4 acoustic neuroma 10.7
5 intracranial hypertension 10.7
6 neurilemmoma 10.6
7 meningitis 10.6
8 neuroma 10.6
9 encephalocele 10.5
10 pituitary adenoma 10.5
11 meningocele 10.5
12 hydrocephalus 10.5
13 adenoma 10.4
14 mollaret meningitis 10.4
15 meningoencephalocele 10.4
16 meningioma, familial 10.4
17 intracranial meningioma 10.4
18 craniopharyngioma 10.4
19 secretory meningioma 10.4
20 lymphoplasmacyte-rich meningioma 10.4
21 body mass index quantitative trait locus 1 10.3
22 sleep apnea 10.3
23 rhinitis 10.3
24 diabetes insipidus 10.3
25 pituitary tumors 10.3
26 chordoma 10.2
27 intracranial hypertension, idiopathic 10.2
28 allergic rhinitis 10.2
29 spondylosis 10.2
30 squamous cell papilloma 10.2
31 papilloma 10.2
32 migraine with or without aura 1 10.1
33 spondylosis, cervical 10.1
34 trigeminal neuralgia 10.1
35 ocular motor apraxia 10.1
36 ossification of the posterior longitudinal ligament of spine 10.1
37 nasopharyngeal carcinoma 10.1
38 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.1
39 ifap syndrome 2 10.1
40 inguinal hernia 10.1
41 cholesteatoma of middle ear 10.1
42 papilledema 10.1
43 olfactory neuroblastoma 10.1
44 radiculopathy 10.1
45 skull base meningioma 10.1
46 spinal stenosis 10.1
47 mucormycosis 10.1
48 decubitus ulcer 10.1
49 degenerative disc disease 10.1
50 bacterial meningitis 10.1

Graphical network of the top 20 diseases related to Cerebrospinal Fluid Leak:



Diseases related to Cerebrospinal Fluid Leak

Symptoms & Phenotypes for Cerebrospinal Fluid Leak

UMLS symptoms related to Cerebrospinal Fluid Leak:


seizures; vertigo; pain; meningism; reflex, abnormal; neurobehavioral manifestations; neuromuscular manifestations

Drugs & Therapeutics for Cerebrospinal Fluid Leak

Drugs for Cerebrospinal Fluid Leak (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational Phase 4
2 Hemostatics Phase 4
3 Fibrin Tissue Adhesive Phase 4
4 Coagulants Phase 4
5
tannic acid Approved 1401-55-4
6
Norepinephrine Approved 51-41-2 439260
7
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
8
Morphine Approved, Investigational 57-27-2 5288826
9
Polyestradiol phosphate Approved 28014-46-2
10
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
11
Chitosan Experimental 9012-76-4 71853
12 Chelating Agents
13 Antimetabolites
14 Lipid Regulating Agents
15 Anticholesteremic Agents
16 Hypolipidemic Agents
17 Narcotics
18 Analgesics
19 Analgesics, Opioid
20 Hormone Antagonists
21 Estradiol 3-benzoate
22 Contraceptive Agents
23 Estradiol 17 beta-cypionate
24 Hormones
25 Estrogens

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 A Prospective Randomized Controlled Study Evaluating the Safety and Efficacy of EVICEL® Used for Suture-Line Sealing in Dura-Mater Closure During Paediatric Neurosurgical Cranial Procedures Recruiting NCT02309645 Phase 4
2 Sphenopalatine Ganglion Nerve Block for Postdural Puncture Headache in Obstetrics Withdrawn NCT03181464 Phase 4 Lidocaine 4%;Placebo
3 TachoSil® Versus Current Practice in Dura Sealing Techniques for the Prevention of Post-operative Cerebrospinal Fluid (CSF) Leaks in Patients Undergoing Skull Base Surgery: An Open Label, Randomised, Controlled, Multi-centre, Parallel Group Efficacy and Safety Trial. Completed NCT01355627 Phase 3
4 A Randomised Controlled Study to Evaluate the Efficacy and Safety of Fibrin Sealant, Vapour Heated, Solvent/Detergent Treated FS VH S/D 500 S-apr (Tisseel) Compared to DuraSeal Dural Sealant as an Adjunct to Sutured Dural Repair in Cranial Surgery. Completed NCT02891070 Phase 3 FS VH S/D 500 s-apr
5 A Single-Blinded, Randomized, Controlled Study to Evaluate the Safety and Effectiveness of EVICEL® Fibrin Sealant (Human) Compared to a Hydrogel Sealant as an Adjunct to Sutured Dural Repair Completed NCT02457546 Phase 3
6 A Prospective, Randomized, Controlled, Single Blinded, Study to Evaluate the Safety and Effectiveness of Bioseal as an Adjunct to Sutured Dural Repair Completed NCT03110783 Phase 3
7 A Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for Treatment of Cerebrospinal Fluid Leaks in Spontaneous Intracranial Hypotension. Completed NCT03276975 Phase 2 TISSEEL
8 Pilot Study of Acetazolamide to Prevent Post Operative Cerebrospinal Fluid (CSF) Leak in Patients Undergoing Endoscopic Skull Base Surgery Recruiting NCT04351061 Phase 2 Acetazolamide
9 Pilot Study of Acetazolamide to Prevent Post Operative Cerebrospinal Fluid (CSF) Leak in Patients Undergoing Endoscopic Skull Base Surgery Withdrawn NCT02902133 Phase 2 Acetazolamide
10 Flat Bed Rest vs. Immediate Mobilisation After Incidental Durotomy During Lumbar Spinal Surgery: A Prospective Randomised Trial Unknown status NCT02927782
11 VALUE OF RADIONUCLIDE CISTERNOGRAPHY IN PATIENTS WITH CEREBROSPINAL FLUID LEAK Completed NCT02876614
12 Evaluation of a Simulation Based Workshop to Enhance Learning of Insertion and Management of CSF Drainage Catheters in an Anesthesia Residency Program Completed NCT03545984
13 A Multi-Center, Randomized, Controlled, Trial of Cerebrospinal Fluid Drainage (CSFD) in Acute Spinal Cord Injury Completed NCT02495545
14 Single-arm, Open-label, Multicenter Study to Evaluate the Safety and Performance of Dura Sealant Patch in Reducing CSF Leakage Following Elective Cranial Surgery Completed NCT03566602
15 Auftreten Von Okkultem Asymptomatischem Liqourverlust Nach Nebenhöhlenoperationen Eine Prospektive Kohortenstudie Completed NCT02382692
16 A Prospective, Multi-Center, Randomized Controlled Study to Compare the Spinal Sealant System as an Adjunct to Sutured Dural Repair With Standard of Care Methods During Spinal Surgery Completed NCT00444067
17 A Prospective, Open, Multi-center, Single-arm Study of the Performance and Safety of I-020805 in the Prevention of Cerebrospinal Fluid Leakage Following Elective Cranial Surgery Completed NCT01295619
18 Chitosan Scaffold for Sellar Floor Repair in Endoscopic Endonasal Transsphenoidal Surgery Completed NCT03280849
19 International Opinion Study on Peri-operative Cerebrospinal Fluid Leaks Management After Endoscopic Skull Base Surgery Completed NCT04124523
20 Incidence of Post-Dural Puncture Headache Following Unintentional Dural Puncture: A Randomized Trial of Intrathecal Morphine Versus Saline Completed NCT01977898 Morphine;Saline
21 Chronic Headache and Chronic Backache Following Unintentional Dural Puncture at Delivery Room Completed NCT03908424
22 Cone Beam CT (CS 9300) for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower Dose Completed NCT01855425
23 Post-market Clinical Data Collection Plan for the Biodesign® Dural and Duraplasty Grafts Recruiting NCT04057157
24 A Prospective, Multi-center, Randomized, Parallel-controlled Clinical Trial Evaluating the Efficacy and Safety of Lyoplant Onlay in Repairing Cerebral Dura Mater Recruiting NCT04490629
25 A Prospective, Randomized, Controlled Multi-center Study of ArtiFascia® Dural Repair Patch Compared With Commercially Available Dural Substitutes- NEOART Study. Recruiting NCT04145544
26 Multimodal Sonographic Monitoring of Cerebral Perfusion, Ventricle Seize and Optic Nerve Diameter During Weaning of Cerebrospinal Fluid Drainage Catheters: a Single Centre Observational Trial Recruiting NCT02408757
27 Evaluation of Outcomes Related to Cerebrospinal Fluid Drains Placed Either With or Without Fluoroscopic Guidance for Aortic Surgery Active, not recruiting NCT04505423
28 The Effect of an ASC-seeded Collagen Hydrogel on Cerebrospinal Fluid Leak Rates Following Skull Base Surgery Not yet recruiting NCT04503161
29 Free Middle Turbinate Flap for Repair of Low Flow Cerebrospinal Fluid Leak Not yet recruiting NCT04784169
30 Randomized, Two-arm, Multicenter Study to Evaluate the Safety and Efficacy of Dura Sealant Patch in Reducing CSF Leakage Following Elective Cranial Surgery Not yet recruiting NCT04086550
31 Spontaneous Spinal Cerebrospinal Fluid Leaks and Intracranial Hypotension Suspended NCT02603549
32 CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar Tap Withdrawn NCT01932255

Search NIH Clinical Center for Cerebrospinal Fluid Leak

Genetic Tests for Cerebrospinal Fluid Leak

Anatomical Context for Cerebrospinal Fluid Leak

MalaCards organs/tissues related to Cerebrospinal Fluid Leak:

40
Pituitary, Brain, Bone, Spinal Cord, Temporal Lobe, Cerebellum, Bone Marrow

Publications for Cerebrospinal Fluid Leak

Articles related to Cerebrospinal Fluid Leak:

(show top 50) (show all 1882)
# Title Authors PMID Year
1
Four-Year Treatment Outcomes of Children Operated for Neural Tube Defect in Addis Ababa, Ethiopia: A Retrospective Study. 61
33540093 2021
2
Vestibular Schwannoma Surgery: Outcome and Complications in Lateral Decubitus Position versus Semi-sitting Position-A Personal Learning Curve in a Series of 544 Cases over 3 Decades. 61
33383200 2021
3
Safety and Effectiveness of the Direct Endoscopic Endonasal Approach for Primary Sellar Pathology: A Contemporary Case Series of More Than 400 Patients. 61
33454431 2021
4
[Post-dural puncture headache]. 61
33725180 2021
5
Frontal Sinus Morphometry in Relation to Surgically Relevant Landmarks in the Middle East Population: Can We Globalize? 61
33309894 2021
6
The Feasibility of Magnetic Resonance Imaging for the Differentiation of Cerebrospinal Fluid Leak From Middle Ear Effusion: A Quantitative Analysis. 61
33347051 2021
7
Diagnostic Yield of Lateral Decubitus Digital Subtraction Myelogram Stratified by Brain MRI Findings. 61
33472917 2021
8
Prediction of Postoperative Risk of Raised Intracranial Pressure After Spontaneous Skull Base Cerebrospinal Fluid Leak Repair. 61
33734152 2021
9
Clinical Presentation, Investigation Findings, and Treatment Outcomes of Spontaneous Intracranial Hypotension Syndrome: A Systematic Review and Meta-analysis. 61
33393980 2021
10
Risk factor for cerebrospinal fluid leak after endoscopic endonasal skull base surgery: a single-center experience. 61
33733997 2021
11
Prospective study of surgery for traumatic brain injury in Addis Ababa, Ethiopia: Surgical procedures, complications and postoperative outcomes. 61
33706016 2021
12
Endoscopic Endonasal Approach to Multilobular Giant Pituitary Adenoma with Cavernous Sinus Invasion and Petroclival Extension. 61
33220473 2021
13
Outcomes of Transsphenoidal Microsurgery for Prolactinomas - A Contemporary Series of 162 Cases. 61
33461233 2021
14
Trends in cerebrospinal fluid leak rates following the extended endoscopic endonasal approach for anterior skull base meningioma: a meta-analysis over the last 20 years. 61
33188605 2021
15
The endoscope-assisted supraorbital "keyhole" approach for anterior skull base meningiomas: an updated meta-analysis. 61
32889640 2021
16
Commentary: Safety of Early Mobilization in Patients With Intra-Operative Cerebrospinal Fluid Leak in Minimally Invasive Spine Surgery: A Case Series. 61
33733678 2021
17
Sternberg's Canal and Defect: Is the Lateral Craniopharyngeal Canal a Source of Spontaneous Cerebrospinal Fluid Leak? Anatomic and Radiological Analysis in Pediatric and Adult Populations. 61
33475703 2021
18
Spontaneous Spinal Cerebrospinal Fluid Leak: Review and Management Algorithm. 61
33798778 2021
19
Simulation of Cerebrospinal Fluid Leak Repair Using a 3-Dimensional Printed Model. 61
33745321 2021
20
Cerebrospinal Fluid Leak Repair Simulation Model: Face, Content, and Construct Validation. 61
32819147 2021
21
Community-acquired Haemophilus influenzae meningitis in adults. 61
33774020 2021
22
Temporoparietal Fascia Flap Endonasal Transposition in Skull Base Reconstruction: Surgical Technique. 61
33166688 2021
23
Arachnoiditis, a complication of epidural blood patch for the treatment of low-pressure headache: A case report and systematic review. 61
33583044 2021
24
Recurrent Meningitis in Congenital Inner Ear Malformation. 61
32320299 2021
25
Spinal Compliance Curves: Preliminary Experience with a New Tool for Evaluating Suspected CSF Venous Fistulas on CT Myelography in Patients with Spontaneous Intracranial Hypotension. 61
33602750 2021
26
Spontaneous spinal cerebrospinal fluid-venous fistulas in patients with orthostatic headaches and normal conventional brain and spine imaging. 61
33484155 2021
27
The sellar barrier on preoperative imaging predicts intraoperative cerebrospinal fluid leak: a prospective multicenter cohort study. 61
32918661 2021
28
Complications following titanium cranioplasty compared with nontitanium implants cranioplasty: A systematic review and meta-analysis. 61
33485602 2021
29
Step Back in Order to Go Forward: Willful Enlargement and Sandwich Closure Technique for Spinal Dura Repair after Several Unsuccessful Closure Attempts. 61
33540456 2021
30
Minimally Invasive Resection of Spinal Tumors with Tubular Retractor: Case Series, Surgical Technique, and Outcome. 61
33548528 2021
31
Two-Stage Approach for Unstable Pediatric Craniocervical Junction Anomalies with a Halo Vest and Delayed Occipitocervical Fusion: Technical Note, Case Series, and Literature Review. 61
33227530 2021
32
Efficacy of unilateral hemilaminectomy for intraspinal tumor resection: a systematic review and meta-analysis. 61
32954745 2021
33
Pretruncal Subarachnoid Hemorrhage in a Patient with Cerebrospinal Fluid Leak. 61
32588332 2021
34
Cerebrospinal Fluid Leak During Stapes Surgery: The Importance of Temporal Bone CT Reconstructions in Oblique Anatomically Oriented Planes. 61
33624550 2021
35
Tension pneumocephalus following an implant removal from spine. 61
33627348 2021
36
Safety of Early Mobilization in Patients With Intraoperative Cerebrospinal Fluid Leak in Minimally Invasive Spine Surgery: A Case Series. 61
33609122 2021
37
Composite Chondromucosal Nasoseptal Flap for Reconstruction of Suprasellar Defects. 61
33556598 2021
38
Endoscopic "Quick" Septoplasty in Preservation Rhinoplasty. 61
32541536 2021
39
Dorsal Preservation Rhinoplasty: Measures to Prevent Suboptimal Outcomes. 61
33220839 2021
40
Cerebrospinal Fluid-Venous Fistulas: A Systematic Review and Examination of Individual Patient Data. 61
33438744 2021
41
Bilateral Subdural Hygromas After Deep Brain Stimulation Implantation in the Setting of Unrecognized Intracranial Hypotension. 61
33680583 2021
42
Resistant Temporal Lobe Epilepsy: Initial Steps into a Bigger Epilepsy Surgery Program. 61
33531782 2021
43
Posterior Cranial Vault Distraction (PCVD): Common Complication Rates and Strategies of Prevention and Management. 61
33136783 2021
44
Cerebrospinal Fluid Leak Following Translabyrinthine Vestibular Schwannoma Surgery-Is Mesh Cranioplasty Necessary for Prevention? 61
33443978 2021
45
Middle Cranial Fossa Approach to Vestibular Schwannoma Resection in the Older Patient Population. 61
32947493 2021
46
Cerebrospinal Fluid Leak After Septoplasty in Crouzon Syndrome. 61
33027174 2021
47
Atypical presentations of idiopathic intracranial hypertension. 61
33767953 2021
48
The domino effect of acephalgic spontaneous intracranial hypotension. 61
32989589 2021
49
Clinical applications of the endoscopic transorbital approach for various lesions. 61
33394139 2021
50
Meningitis due to cerebrospinal fluid leak after nasal swab testing for COVID-19. 61
33480112 2021

Variations for Cerebrospinal Fluid Leak

Expression for Cerebrospinal Fluid Leak

Search GEO for disease gene expression data for Cerebrospinal Fluid Leak.

Pathways for Cerebrospinal Fluid Leak

GO Terms for Cerebrospinal Fluid Leak

Cellular components related to Cerebrospinal Fluid Leak according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perinuclear region of cytoplasm GO:0048471 8.62 TPPP3 PTGDS

Sources for Cerebrospinal Fluid Leak

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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