Cerebrospinal Fluid Leak disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

GARD: ¹⁹ It is a rare but very serious condition that requires rapid intervention. Symptoms include leak of clear fluid through the ear, inflammation of the membranes that cover the brain (meningitis), hearing loss, and seizures. The cause of a spinal fluid leak through the ear is a defect of the bone and meningeal layers covering the brain that separate the subarachnoid space of the brain from the middle ear and mastoid bone (located just behind the ear). The leaks occur after a surgery in the base of the skull, temporal bone fractures, congenital defects of the inner ear, trauma, or they may be spontaneous.

MalaCards based summary: Cerebrospinal Fluid Leak, also known as spinal cerebrospinal fluid leak, is related to spontaneous intracranial hypotension and intracranial hypotension, and has symptoms including vertigo, pain and seizures. An important gene associated with Cerebrospinal Fluid Leak is PTGDS (Prostaglandin D2 Synthase). The drugs Thrombin and Fibrin Tissue Adhesive have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and brain.

Wikipedia: ⁷⁵ A cerebrospinal fluid leak (CSF leak or CSFL) is a medical condition where the cerebrospinal fluid (CSF)... more...

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Related Diseases for Cerebrospinal Fluid Leak

Diseases related to Cerebrospinal Fluid Leak via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 238)

#	Related Disease	Score
1	spontaneous intracranial hypotension	11.9
2	intracranial hypotension	10.9
3	acoustic neuroma	10.7
4	intracranial hypertension	10.7
5	headache	10.7
6	neurilemmoma	10.7
7	intracranial hypertension, idiopathic	10.7
8	otorrhea	10.6
9	pituitary adenoma	10.6
10	meningitis	10.6
11	encephalocele	10.6
12	adenoma	10.6
13	neuroma	10.6
14	meningioma, familial	10.5
15	meningocele	10.5
16	hydrocephalus	10.5
17	meningoencephalocele	10.4
18	craniopharyngioma	10.4
19	spinal stenosis	10.4
20	bacterial meningitis	10.4
21	chordoma	10.3
22	central diabetes insipidus	10.3
23	gorham's disease	10.3
24	diabetes insipidus	10.3
25	pituitary tumors	10.3
26	apnea, obstructive sleep	10.3
27	cystic angiomatosis of bone, diffuse	10.3
28	body mass index quantitative trait locus 1	10.3
29	nasopharyngeal carcinoma	10.3
30	empty sella syndrome	10.3
31	rhinitis	10.3
32	chronic rhinitis	10.3
33	hypertension, essential	10.2
34	trigeminal neuralgia	10.2
35	ocular motor apraxia	10.2
36	allergic rhinitis	10.2
37	sleep apnea	10.2
38	spondylosis	10.2
39	spinal cord disease	10.2
40	radiculopathy	10.2
41	degenerative disc disease	10.2
42	papilloma	10.2
43	chiari malformation type i	10.1
44	ear malformation	10.1
45	spondylosis, cervical	10.1
46	neuraminidase deficiency	10.1
47	deafness, autosomal recessive 4, with enlarged vestibular aqueduct	10.1
48	ossification of the posterior longitudinal ligament of spine	10.1
49	inguinal hernia	10.1
50	osteonecrosis	10.1

Graphical network of the top 20 diseases related to Cerebrospinal Fluid Leak:

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Symptoms & Phenotypes for Cerebrospinal Fluid Leak

UMLS symptoms related to Cerebrospinal Fluid Leak:

vertigo; pain; seizures; meningism; reflex, abnormal; neurobehavioral manifestations; neuromuscular manifestations

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Drugs & Therapeutics for Cerebrospinal Fluid Leak

Drugs for Cerebrospinal Fluid Leak (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Thrombin

Approved, Investigational

Phase 3

2

Fibrin Tissue Adhesive

Phase 3

3

Hemostatics

Phase 3

4

Coagulants

Phase 3

5

Morphine

Approved, Investigational

57-27-2

5288826

6

Norepinephrine

Approved

51-41-2

439260

7

Benzocaine

Approved, Investigational

1994-09-7, 94-09-7

2337

8

Tannic acid

Approved

1401-55-4

16129878 16129778

9

Chitosan low molecular weight (20-200 mpa.s)

Experimental

14257-69-3, 9012-76-4

441477 71853

10

Analgesics

11

Analgesics, Opioid

12

Narcotics

13

Antimetabolites

14

Hypolipidemic Agents

15

Anticholesteremic Agents

16

Lipid Regulating Agents

17

Chelating Agents

Interventional clinical trials:

(show all 31)

#	Name	Status	NCT ID	Phase	Drugs
1	Sphenopalatine Ganglion Nerve Block for Postdural Puncture Headache in Obstetrics	Withdrawn	NCT03181464	Phase 4	Lidocaine 4%;Placebo
2	A Single-Blinded, Randomized, Controlled Study to Evaluate the Safety and Effectiveness of EVICEL® Fibrin Sealant (Human) Compared to a Hydrogel Sealant as an Adjunct to Sutured Dural Repair	Completed	NCT02457546	Phase 3
3	A Randomised Controlled Study to Evaluate the Efficacy and Safety of Fibrin Sealant, Vapour Heated, Solvent/Detergent Treated FS VH S/D 500 S-apr (Tisseel) Compared to DuraSeal Dural Sealant as an Adjunct to Sutured Dural Repair in Cranial Surgery.	Completed	NCT02891070	Phase 3	FS VH S/D 500 s-apr
4	TachoSil® Versus Current Practice in Dura Sealing Techniques for the Prevention of Post-operative Cerebrospinal Fluid (CSF) Leaks in Patients Undergoing Skull Base Surgery: An Open Label, Randomised, Controlled, Multi-centre, Parallel Group Efficacy and Safety Trial.	Completed	NCT01355627	Phase 3
5	A Prospective Randomized Controlled Study Evaluating the Safety and Efficacy of EVICEL® Used for Suture-Line Sealing in Dura-Mater Closure During Paediatric Neurosurgical Cranial Procedures	Terminated	NCT02309645	Phase 3
6	A Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for Treatment of Cerebrospinal Fluid Leaks in Spontaneous Intracranial Hypotension.	Completed	NCT03276975	Phase 2	TISSEEL
7	Pilot Study of Acetazolamide to Prevent Post Operative Cerebrospinal Fluid (CSF) Leak in Patients Undergoing Endoscopic Skull Base Surgery	Withdrawn	NCT04351061	Phase 2	Acetazolamide
8	Pilot Study of Acetazolamide to Prevent Post Operative Cerebrospinal Fluid (CSF) Leak in Patients Undergoing Endoscopic Skull Base Surgery	Withdrawn	NCT02902133	Phase 2	Acetazolamide
9	A Prospective, Multi-center, Randomized, Parallel-controlled Clinical Trial Evaluating the Efficacy and Safety of Lyoplant Onlay in Repairing Cerebral Dura Mater	Unknown status	NCT04490629
10	Flat Bed Rest vs. Immediate Mobilisation After Incidental Durotomy During Lumbar Spinal Surgery: A Prospective Randomised Trial	Unknown status	NCT02927782
11	International Opinion Study on Peri-operative Cerebrospinal Fluid Leaks Management After Endoscopic Skull Base Surgery	Completed	NCT04124523
12	A Prospective, Multi-Center, Randomized Controlled Study to Compare the Spinal Sealant System as an Adjunct to Sutured Dural Repair With Standard of Care Methods During Spinal Surgery	Completed	NCT00444067
13	Incidence of Post-Dural Puncture Headache Following Unintentional Dural Puncture: A Randomized Trial of Intrathecal Morphine Versus Saline	Completed	NCT01977898		Morphine;Saline
14	Chitosan Scaffold for Sellar Floor Repair in Endoscopic Endonasal Transsphenoidal Surgery	Completed	NCT03280849
15	A Prospective, Randomized, Controlled Multi-center Study of ArtiFascia® Dural Repair Patch Compared With Commercially Available Dural Substitutes- NEOART Study.	Completed	NCT04145544
16	Auftreten Von Okkultem Asymptomatischem Liqourverlust Nach Nebenhöhlenoperationen Eine Prospektive Kohortenstudie	Completed	NCT02382692
17	Evaluation of a Simulation Based Workshop to Enhance Learning of Insertion and Management of CSF Drainage Catheters in an Anesthesia Residency Program	Completed	NCT03545984
18	Post-market Clinical Data Collection Plan for the Biodesign® Dural and Duraplasty Grafts	Completed	NCT04057157
19	Single-arm, Open-label, Multicenter Study to Evaluate the Safety and Performance of Dura Sealant Patch in Reducing CSF Leakage Following Elective Cranial Surgery	Completed	NCT03566602
20	A Multi-Center, Randomized, Controlled, Trial of Cerebrospinal Fluid Drainage (CSFD) in Acute Spinal Cord Injury	Completed	NCT02495545
21	Evaluation of Outcomes Related to Cerebrospinal Fluid Drains Placed Either With or Without Fluoroscopic Guidance for Aortic Surgery	Completed	NCT04505423
22	A Prospective, Open, Multi-center, Single-arm Study of the Performance and Safety of I-020805 in the Prevention of Cerebrospinal Fluid Leakage Following Elective Cranial Surgery	Completed	NCT01295619
23	Outcome of the Endoscopic Repair of Frontal Sinus Cerebrospinal Fluid Leak	Completed	NCT05024643
24	VALUE OF RADIONUCLIDE CISTERNOGRAPHY IN PATIENTS WITH CEREBROSPINAL FLUID LEAK	Completed	NCT02876614
25	Cone Beam CT (CS 9300) for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower Dose	Completed	NCT01855425
26	Randomized, Two-arm, Multicenter Study to Evaluate the Safety and Efficacy of Dura Sealant Patch in Reducing CSF Leakage Following Elective Cranial Surgery	Recruiting	NCT04086550
27	A Multicenter, Retrospective, Post-Market Clinical Follow-Up Study to Evaluate the Performance and Safety of Suturable DuraGen™	Recruiting	NCT04923867
28	Multimodal Sonographic Monitoring of Cerebral Perfusion, Ventricle Seize and Optic Nerve Diameter During Weaning of Cerebrospinal Fluid Drainage Catheters: a Single Centre Observational Trial	Recruiting	NCT02408757
29	Free Middle Turbinate Flap for Repair of Low Flow Cerebrospinal Fluid Leak	Not yet recruiting	NCT04784169
30	The Effect of an ASC-seeded Collagen Hydrogel on Cerebrospinal Fluid Leak Rates Following Skull Base Surgery	Withdrawn	NCT04503161
31	CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar Tap	Withdrawn	NCT01932255

Search NIH Clinical Center for Cerebrospinal Fluid Leak

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Genetic Tests for Cerebrospinal Fluid Leak

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Anatomical Context for Cerebrospinal Fluid Leak

Organs/tissues related to Cerebrospinal Fluid Leak:

MalaCards : Spinal Cord, Bone, Brain, Pituitary, Temporal Lobe, Dorsal Root Ganglion, Caudate Nucleus

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Publications for Cerebrospinal Fluid Leak

Articles related to Cerebrospinal Fluid Leak:

(show top 50) (show all 5047)

#	Title	Authors	PMID	Year
1	Invasive Pneumococcal Disease in High-risk Children: A 10-Year Retrospective Study. ⁶²	van Warmerdam J...Morris SK	36450100	2023
2	Risk Factors in a Pediatric Population for Postoperative Intracranial Infection Following Endoscopic Endonasal Skull Base Surgery and the Role of Antibiotic Prophylaxis. ⁶²	Palmieri D...Snyderman CH	36050937	2023
3	Cerebrospinal Fluid Leaks, Spontaneous Intracranial Hypotension, and Chiari I Malformation. ⁶²	Kumar R...Brinjikji W	36424060	2023
4	"The Up and Down Approach" to Localize and Exclude Sites of Intraspinal CSF Leaks. ⁶²	Gerasymchuk M...Nayate AP	36123203	2023
5	The efficacy and safety of intrathecal fluorescein in endoscopic cerebrospinal fluid leak repair -a systematic review. ⁶²	Jolly K...Ahmed SK	35393153	2022
6	Dural Sealants Do Not Reduce Postoperative Cerebrospinal Fluid Leak after Endoscopic Endonasal Skull Base Surgery. ⁶²	McDowell MM...Gardner PA	36393876	2022
7	Coexistence of flavum ligament ossification with diffuse idiopathic skeletal hyperostosis in the cervical spine: Review of literature and technical note starting from a rare case. ⁶²	Calvanese F...Barrey CY	36087693	2022
8	A simple surgical technique for sellar closure after transsphenoidal resection of pituitary adenomas in the context of risk factors for cerebrospinal fluid leaks and meningitis. ⁶²	Ueberschaer M...Rachinger W	36455277	2022
9	Retrospective Review of Surgical Site Infections after Endoscopic Endonasal Sellar and Parasellar Surgery: Multicenter Quality Data from the North American Skull Base Society. ⁶²	Saleh S...McKean EL	36393885	2022
10	Outcomes of endoscopic endonasal resection of pediatric craniopharyngiomas. ⁶²	Patel TD...Palmer JN	35485414	2022
11	Endoscopic Repair of Round Window Cochleocele. ⁶²	James AL...Papsin BC	36156534	2022
12	Infrapedicular approach to CT-guided thermal ablation in the thoracic spine. ⁶²	Burkett B...Morris JM	35574645	2022
13	Endoscopic pituitary surgery: National database review. ⁶²	Al-Qurayshi Z...Graham SM	36039744	2022
14	Incidence and Management of Facial Paralysis After Skull Base Trauma, an Administrative Database Study. ⁶²	Wamkpah NS...Durakovic N	36214506	2022
15	A phase 1/2a dose-escalation study of oligodendrocyte progenitor cells in individuals with subacute cervical spinal cord injury. ⁶²	Fessler RG...McKenna SL	35901693	2022
16	Growing fat tissue after grafting for dural sealing. ⁶²	Gruter BE...Andereggen L	36436776	2022
17	Chiari Type III : Experience of Outcome for 15 Cases. ⁶²	Gabr M...Abdullah AA	36281538	2022
18	Pediatric basilar skull fractures from multi-level falls: A systematic review and retrospective analysis. ⁶²	Barba P...Magit A	36030630	2022
19	Incidental Durotomy Repair in Lumbar Spine Surgery: Institutional Experience and Review of Literature. ⁶²	Albayar A...Welch WC	36426799	2022
20	Endoscopic Treatment of Rathke's Cleft Cysts: The Case for Simple Fenestration. ⁶²	Millesi M...Kalyvas A	36358408	2022
21	SNOT-22 Quality of Life Scores Improve After Endoscopic Endonasal Repair of Spontaneous Cerebrospinal Fluid Rhinorrhea. ⁶²	Liu MY...Chen PG	36377064	2022
22	Impact of surgical factors on delayed hyponatremia in patients with nonfunctioning pituitary adenoma after endonasal endoscopic transsphenoidal procedure. ⁶²	Tanaka H...Nakase H	35984619	2022
23	Starting point for benchmarking outcomes and reporting of pituitary adenoma surgery within the European Reference Network on Rare Endocrine Conditions (Endo-ERN): results from a meta-analysis and survey study. ⁶²	Zamanipoor Najafabadi AH...Biermasz NR	36327151	2022
24	Microvascular Reconstruction of the Anterior Skull Base. ⁶²	Nwaba A...Ellis MF	35984035	2022
25	Cerebrospinal Fluid Otorrhea After a Routine Tympanostomy Tube Placement: A Review of the Literature on Hyrtl Fissure. ⁶²	Oney RM...Chen BS	36345799	2022
26	Combined transnasal/transoral endoscopic odontoid resection in pediatric patients: Otolaryngologic considerations to airway management, endoscopic exposure, and complication management. ⁶²	Grimmer JF...Brockmeyer DL	36402000	2022
27	Novel use of nonpenetrating titanium clips for pediatric primary spinal dural closure: A technical note. ⁶²	Shahrestani S...Levy ML	36084429	2022
28	Anterior and Lateral Skull Base Spontaneous CSF Leaks: Evaluation of Comorbidities and Treatment Outcomes. ⁶²	Hentati F...Mowry SE	36377071	2022
29	Minimally invasive endoscopic approaches to pediatric skull base pathologies. ⁶²	Yu S...Evans JJ	36206699	2022
30	Risk Factors for Postoperative Cerebrospinal Fluid Leak after Graded Multilayer Cranial Base Repair with Suturing via the Endoscopic Endonasal Approach. ⁶²	Hara T...Ishikawa E	36436977	2022
31	Case report: Meningoencephalocele and recurrent bacterial meningitis in chronic idiopathic intracranial hypertension. ⁶²	Zhang J...Han J	36368955	2022
32	Expanding the clinical spectrum of idiopathic intracranial hypertension. ⁶²	Chen BS...Britton JOT	36444979	2022
33	Neuroimaging in the diagnosis and treatment of intracranial pressure disorders. ⁶²	Moreno ME...Del Carpio-O'Donovan R	36333629	2022
34	Spontaneous intracranial hypotension: updates from diagnosis to treatment. ⁶²	Farnsworth PJ...Lehman VT	36336758	2022
35	Transosseous Reconstruction of the Myofascial Layer After Suboccipital Craniotomy to Reduce the Rate of Pseudomeningocele Formation and Cerebrospinal Fluid Leak: A Technical Note. ⁶²	Soto JM...Huang JH	36396054	2022
36	Delayed Cerebrospinal Fluid Leaks Complicating Endoscopic Orbital Surgeries. ⁶²	Yang M...Zhuang A	36372926	2022
37	Direct Anterior Repair of Spontaneous Ventral Cervical Cerebrospinal Fluid Leak: 2-Dimensional Operative Video. ⁶²	Lewis CS...Pham MH	36374029	2022
38	Imaging, Clinical, and Demographic Differences in Patients With Type III Spinal Cerebrospinal Fluid Leak (Cerebrospinal Venous Fistulas) Compared With Patients With Types I and II Spinal Cerebrospinal Fluid Leak. ⁶²	Mehan WA...Buch K	36112050	2022
39	CSF Flow and Spinal Cord Motion in Patients With Spontaneous Intracranial Hypotension: A Phase Contrast MRI Study. ⁶²	Wolf K...Urbach H	36357188	2022
40	Case report: Recurrent spontaneous cerebrospinal fluid (CSF) leak. ⁶²	Alsaeedi BS...Bhat IN	36334550	2022
41	Comparison of Graft Materials in Multilayer Reconstruction with Nasoseptal Flap for High-Flow CSF Leak during Endoscopic Skull Base Surgery. ⁶²	Kim BK...Hong SD	36431187	2022
42	CSF leak complicating the infralabyrinthine approach to petrous apex: lessons learnt. ⁶²	Chowdhary S...Penubarthi LK	36414351	2022
43	Systematic Review: Evaluating the Efficacy of Intrathecal Fluorescein for Localizing Cerebrospinal Fluid Rhinorrhea. ⁶²	Romeo D...Rajasekaran K	36409876	2022
44	[Diagnostic value of computed tomographic cisternography and magnetic resonance hydrography in cerebrospinal fluid rhinorrhea]. ⁶²	Lu X...Liu G	36347580	2022
45	Phase Contrast Spine MRI for the Evaluation of CSF Leak, and Why It Matters. ⁶²	Carroll I...Callen A	36357186	2022
46	Investigating acetazolamide effectiveness on CSF leak in adult patients after spinal surgery. ⁶²	Kankam SB...Khoshnevisan A	35811251	2022
47	Treatment Patterns and Health Care Resource Utilization of Iatrogenic Spinal Cerebrospinal Fluid Leaks in the United States. ⁶²	Charalambous LT...Lad SP	35858207	2022
48	Management of Traumatic and Non-Traumatic Cerebrospinal Fluid Rhinorrhea-Experience from Three Southeast Asian Countries. ⁶²	Zahedi FD...Abdullah B	36360727	2022
49	Endoscopic Endonasal Transsphenoidal Approach to Repair Cerebrospinal Fluid Rhinorrhea After an Anterior Clinoidectomy for Aneurysm Clipping: Series of 4 Cases. ⁶²	Shaftel KA...Little AS	36227187	2022
50	Surgical Site Infection in the Intensive Care Setting After Posterior Spinal Fusion: A Case Series Highlighting the Microbial Profile, Risk Factors, and the Importance of Comorbid Disease Burden. ⁶²	Cloney MB...Dahdaleh NS	36103357	2022

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Genes for Cerebrospinal Fluid Leak

Genes related to Cerebrospinal Fluid Leak (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	PTGDS	Prostaglandin D2 Synthase	Protein Coding	8.18	GeneCards inferred via : Publications (show sections)

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Variations for Cerebrospinal Fluid Leak

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Expression for Cerebrospinal Fluid Leak

Search GEO for disease gene expression data for Cerebrospinal Fluid Leak.

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Pathways for Cerebrospinal Fluid Leak

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GO Terms for Cerebrospinal Fluid Leak

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Sources for Cerebrospinal Fluid Leak

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: CRB079 MIFTS: 35	Cerebrospinal Fluid Leak Categories: Ear diseases, Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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