MCID: CRB079
MIFTS: 39

Cerebrospinal Fluid Leak

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Cerebrospinal Fluid Leak

MalaCards integrated aliases for Cerebrospinal Fluid Leak:

Name: Cerebrospinal Fluid Leak 54 74
Spinal Cerebrospinal Fluid Leak 74
Cerebrospinal Fluid Rhinorrhea 74
Spinal Csf Leak 54
Csf Rhinorrhea 54
Csf Otorrhea 54
Csf Leak 54

Classifications:



External Ids:

ICD10 34 G96.0

Summaries for Cerebrospinal Fluid Leak

NIH Rare Diseases : 54 Cerebrospinal fluid (CSF) otorrhea is the leakage of cerebrospinal fluid (CSF) though the ear. It is a rare but very serious condition that requires rapid intervention. Symptoms include leak of clear fluid through the ear, inflammation of the membranes that cover the brain (meningitis), hearing loss, and seizures. The cause of a spinal fluid leak through the ear is a defect of the bone and meningeal layers covering the brain that separate the subarachnoid space of the brain from the middle ear and mastoid bone (located just behind the ear). The leaks occur after a surgery in the base of the skull, temporal bone fractures, congenital defects of the inner ear, trauma, or they may be spontaneous. Treatment depends on the cause and may include antibiotics, compression dressing and surgery. 

MalaCards based summary : Cerebrospinal Fluid Leak, also known as spinal cerebrospinal fluid leak, is related to spontaneous intracranial hypotension and intracranial hypotension, and has symptoms including seizures, vertigo and pain. An important gene associated with Cerebrospinal Fluid Leak is PTGDS (Prostaglandin D2 Synthase). The drugs Thrombin and Ropivacaine have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and pituitary.

Related Diseases for Cerebrospinal Fluid Leak

Diseases related to Cerebrospinal Fluid Leak via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 spontaneous intracranial hypotension 12.5
2 intracranial hypotension 11.6
3 headache 10.5
4 acoustic neuroma 10.5
5 intracranial hypertension 10.5
6 meningitis 10.5
7 neuroma 10.4
8 encephalocele 10.2
9 body mass index quantitative trait locus 1 10.2
10 pituitary adenoma 10.1
11 adenoma 10.1
12 allergic rhinitis 10.0
13 hydrocephalus 10.0
14 neurilemmoma 10.0
15 rhinitis 10.0
16 decubitus ulcer 10.0
17 bacterial meningitis 10.0
18 congenital hydrocephalus 10.0
19 meningoencephalocele 10.0
20 ear malformation 10.0
21 meningioma, familial 10.0
22 spinal meningioma 10.0
23 secretory meningioma 10.0
24 lymphangiomatosis 10.0
25 chiari malformation 9.9
26 hydrocephalus due to congenital stenosis of aqueduct of sylvius 9.9
27 papilloma of choroid plexus 9.9
28 papilloma 9.9
29 arachnoid cysts 9.9
30 perilymphatic fistula 9.9
31 glioma susceptibility 1 9.9
32 marfan syndrome 9.9
33 neural tube defects 9.9
34 lung cancer 9.9
35 dandy-walker syndrome 9.9
36 ocular motor apraxia 9.9
37 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 9.9
38 breast reconstruction 9.9
39 spinal stenosis 9.9
40 myelomeningocele 9.9
41 cryptococcal meningitis 9.9
42 osteomyelitis 9.9
43 meningocele 9.9
44 intracranial aneurysm 9.9
45 glioblastoma multiforme 9.9
46 oligodendroglioma 9.9
47 cerebellopontine angle tumor 9.9
48 empty sella syndrome 9.9
49 hidrocystoma 9.9
50 radiculopathy 9.9

Graphical network of the top 20 diseases related to Cerebrospinal Fluid Leak:



Diseases related to Cerebrospinal Fluid Leak

Symptoms & Phenotypes for Cerebrospinal Fluid Leak

UMLS symptoms related to Cerebrospinal Fluid Leak:


seizures, vertigo, pain, meningism, reflex, abnormal, neurobehavioral manifestations, neuromuscular manifestations

Drugs & Therapeutics for Cerebrospinal Fluid Leak

Drugs for Cerebrospinal Fluid Leak (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 97)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational Phase 4,Phase 3,Phase 2
2
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
3
Racepinephrine Approved Phase 4 329-65-7 838
4
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
5 Anesthetics Phase 4,Phase 2,Not Applicable
6 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
7 Coagulants Phase 4,Phase 3,Phase 2,Not Applicable
8 Fibrin Tissue Adhesive Phase 4,Phase 3,Phase 2,Not Applicable
9 Hemostatics Phase 4,Phase 3,Phase 2,Not Applicable
10 Pharmaceutical Solutions Phase 4,Phase 3
11 Anesthetics, Local Phase 4,Not Applicable
12 Peripheral Nervous System Agents Phase 4,Not Applicable
13 Epinephryl borate Phase 4
14
Loperamide Approved Phase 3 53179-11-6 3955
15 Gastrointestinal Agents Phase 3
16 Antidiarrheals Phase 3
17 Antisecretory factor Phase 3
18
Acetazolamide Approved, Vet_approved Phase 2,Not Applicable 59-66-5 1986
19
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
20
Probenecid Approved, Investigational Phase 1, Phase 2 57-66-9 4911
21
Acetylcysteine Approved, Investigational Phase 1, Phase 2 616-91-1 12035
22
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
23
Carmustine Approved, Investigational Phase 2 154-93-8 2578
24
Aminolevulinic acid Approved Phase 2 106-60-5 137
25
Norepinephrine Approved Phase 2 51-41-2 439260
26
tannic acid Approved Phase 2 1401-55-4
27
Benzocaine Approved, Investigational Phase 2 94-09-7, 1994-09-7 2337
28
Serine Approved, Nutraceutical Phase 2 56-45-1 5951
29
Levulinic acid Experimental Phase 2 123-76-2 11579
30 Natriuretic Agents Phase 2,Not Applicable
31 Carbonic Anhydrase Inhibitors Phase 2,Not Applicable
32 diuretics Phase 2,Not Applicable
33 Anticonvulsants Phase 2,Not Applicable
34 GABA Agents Phase 2
35 Hypnotics and Sedatives Phase 2
36 Tranquilizing Agents Phase 2
37 Anesthetics, General Phase 2
38 Anti-Anxiety Agents Phase 2
39 Adjuvants, Anesthesia Phase 2
40 GABA Modulators Phase 2
41 Psychotropic Drugs Phase 2
42 Anesthetics, Intravenous Phase 2
43 Neurotransmitter Agents Phase 2
44 Dihydroxyphenylalanine Phase 2,Phase 1
45 Antiparkinson Agents Phase 2,Phase 1
46 Dopa Decarboxylase Phase 2,Phase 1
47 Serine Proteinase Inhibitors Phase 2
48
protease inhibitors Phase 2
49 Trypsin Inhibitors Phase 2
50 HIV Protease Inhibitors Phase 2

Interventional clinical trials:

(show top 50) (show all 70)
# Name Status NCT ID Phase Drugs
1 Efficacy of Tachosil as Dural Sealant Compared to Standard Treatment Completed NCT00999999 Phase 4
2 The Paediatric EVICEL® Neuro Study Recruiting NCT02309645 Phase 4
3 Serratus Plane Versus Paravertebral Nerve Blocks for Breast Surgery Not yet recruiting NCT03860974 Phase 4 Serratus Plane block (single injection);Paravertebral block (single injection)
4 Sphenopalatine Ganglion Nerve Block for Postdural Puncture Headache in Obstetrics Withdrawn NCT03181464 Phase 4 Lidocaine 4%;Placebo
5 The EVICEL® Neurosurgery Phase III Study Completed NCT02457546 Phase 3
6 TASALL - TachoSil® Against Liquor Leak Completed NCT01355627 Phase 3
7 Efficacy and Safety of FS VH S/D 500 S-apr (Tisseel) as an Adjunct to Sutured Dural Repair in Cranial Surgery Completed NCT02891070 Phase 3 FS VH S/D 500 s-apr
8 A Study to Evaluate the Safety and Effectiveness of EVICEL as an Adjunct to Sutured Dural Repair Completed NCT01174992 Phase 2, Phase 3
9 Safety and Effectiveness of the Adherus Dural Sealant System When Used as a Dural Sealant in Cranial Procedures Completed NCT01158378 Phase 3
10 Bioseal Dural Sealing Study BIOS-14-001 Recruiting NCT03110783 Phase 3
11 Effect of Antisecretory Factor, Given as a Food Supplement to Adult Patients With Severe Traumatic Brain Injury Recruiting NCT03339505 Phase 3
12 The Tilburg Vasospasm Study Terminated NCT01407614 Phase 2, Phase 3
13 Effect of Acetazolamide & Position in CSF Leakage and Collection and Wound Dehiscence Unknown status NCT01867268 Phase 2 Acetazolamide
14 Bedside Sedation for the Prevention of Post Dural Puncture Headache Unknown status NCT01503788 Phase 2 Midazolam
15 A Clinical Trial for Treatment of Aromatic L-amino Acid Decarboxylase (AADC) Deficiency Using AAV2-hAADC - An Expansion Unknown status NCT02926066 Phase 2 AAV2-hAADC
16 Fibrin Sealant for the Sealing of Dura Sutures Completed NCT00681824 Phase 2
17 Overcoming Membrane Transporters to Improve CNS Drug Delivery - Improving Brain Antioxidants After Traumatic Brain Injury Completed NCT01322009 Phase 1, Phase 2 Probenecid and N-acetyl cysteine;Placebo
18 Lumbar Drainage in Subarachnoid Haemorrhage Completed NCT00842049 Phase 2
19 Gliadel Wafer and Fluorescence-Guided Surgery With 5-ALA Followed by Radiation Therapy And Temozolomide in Treating Patients With Primary Glioblastoma Completed NCT01310868 Phase 2 5-ALA;Gliadel wafers;Concomitant chemotherapy as normal based on standard clinical protocols determined by the neuro-oncologist;Adjuvant chemotherapy as normal based on standard clinical protocols determined by the neuro-oncologist
20 Pneumococci and Hib Vaccination After Neurotrauma or Neurosurgery Completed NCT02806284 Phase 2
21 A Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for Treatment Recruiting NCT03276975 Phase 2 TISSEEL
22 Cerebrospinal Fluid Drainage (CSFD) in Acute Spinal Cord Injury Recruiting NCT02495545 Phase 2
23 A Phase I/II Clinical Trial for Treatment of Aromatic L-amino Acid Decarboxylase (AADC) Deficiency Using AAV2-hAADC Active, not recruiting NCT01395641 Phase 1, Phase 2 gene therapy
24 Patch vs. No Patch Fetoscopic Meningomyelocele Repair Study Recruiting NCT03794011 Phase 1
25 Mobilisation Algorithm After Incidental Durotomy Unknown status NCT02927782 Not Applicable
26 Study to Evaluate the Safety and Efficacy of Dural Repair Patch in Neurosurgical Repairs Unknown status NCT02129114 Not Applicable
27 Chiari Study Looking at Use of Duragen Versus Duraguard Unknown status NCT00565435
28 Value of Radionuclide Cisternography Completed NCT02876614
29 Performance and Safety of I-020805 in Prevention of Cerebrospinal Fluid (CSF) Leakage Following Elective Craniotomy Completed NCT01295619 Not Applicable
30 A New Cochlear Implant Electrode For Inner Ear Malformations Completed NCT02011867 Not Applicable
31 Study to Evaluate Safety & Effectiveness of Spinal Sealant Completed NCT00444067 Not Applicable
32 Monitoring Patient Cerebro-Spinal Fluid Drainage With an Ultrasonic Flow Sensor Completed NCT00652197
33 Cerebrospinal Fluid Rhinorrhea After Functional Endoscopic Sinus Surgery Completed NCT02382692
34 DuraSeal Exact Spine Sealant System Post-Approval Study Completed NCT01410864
35 Chitosan Scaffold for Sellar Floor Repair in Endoscopic Endonasal Transsphenoidal Surgery Completed NCT03280849 Not Applicable
36 Incidence of Headache Following an Unintentional Dural Puncture Completed NCT01977898 Not Applicable Morphine;Saline
37 A Comparison Between Two Techniques for Performing Decompressive Craniectomy Completed NCT02594137 Not Applicable
38 Estimating EC95 of Remifentanil for Cough Prevention During Emergence From Total Intravenous Anesthesia With Propofol and Remifentanil in Patients Undergoing Transsphenoidal Hypophysectomy Completed NCT01735019 Not Applicable Administration of remifentanil with TCI system
39 Body Mass Index and Post-dural Puncture Headache Completed NCT02999919 Not Applicable
40 Study of Shunt Flow Sensor Accuracy in Extra-ventricular Drains. Completed NCT01108965
41 Alteration in Hearing Following Accidental Dural Puncture. A Study in Parturients Completed NCT01682967
42 DuraSeal Sealant Post Market Study Completed NCT00704340 Not Applicable
43 Influence of Drainage on EVD ICP-signal Completed NCT03164434
44 Prediction of Post-dural Puncture Headache in Parturients Undergoing Elective Caesarean Section Completed NCT03464253
45 Olfactory Dysfunction of Rhinosinusitis - Cyclic Adenosine Monophosphate (cAMP)/Calcium Signaling Study Completed NCT00970190
46 Evaluate the Safety and Performance of Dura Sealant Patch in Reducing CSF Leakage Following Elective Cranial Surgery Recruiting NCT03566602 Not Applicable
47 Sonographic Monitoring of Weaning of Cerebrospinal Fluid Drainages Recruiting NCT02408757
48 L-PRF in Cranial Surgery Recruiting NCT03812120 Not Applicable
49 Effects on the Awakening With Laryngeal Mask vs Endotracheal Tube in Endoscopic Endonasal Transsphenoidal Base Surgery Recruiting NCT02988804 Not Applicable
50 Impact of Herniation on WFNS Grading in Spontaneous Subarachnoid Hemorrhage - a SWISS SOS Observational Trial Recruiting NCT02304328

Search NIH Clinical Center for Cerebrospinal Fluid Leak

Genetic Tests for Cerebrospinal Fluid Leak

Anatomical Context for Cerebrospinal Fluid Leak

MalaCards organs/tissues related to Cerebrospinal Fluid Leak:

42
Bone, Brain, Pituitary, Spinal Cord, Breast, Testes, Bone Marrow

Publications for Cerebrospinal Fluid Leak

Articles related to Cerebrospinal Fluid Leak:

(show top 50) (show all 360)
# Title Authors Year
1
Management of spontaneous temporal bone cerebrospinal fluid leak: A 30-year experience. ( 30472121 )
2019
2
Tension pneumocephalus - A rare complication of cerebrospinal fluid leak. ( 30581524 )
2019
3
Do Most Patients With a Spontaneous Cerebrospinal Fluid Leak Have Idiopathic Intracranial Hypertension? ( 30747786 )
2019
4
Proposal of Standardization of Closure Techniques After Endoscopic Pituitary and Skull Base Surgery Based on Postoperative Cerebrospinal Fluid Leak Risk Classification. ( 30908447 )
2019
5
Cryptococcal Meningitis in a HIV Seronegative Patient: A Rare Complication of Cerebrospinal Fluid Leak Detected with a New Cisternographic Technique. ( 30915245 )
2019
6
Cerebrospinal fluid leak after bone marrow biopsy. ( 29048111 )
2018
7
Corrigendum to "Paradoxical postural cerebrospinal fluid leak-induced headache: Report of two cases" [J Clin Anesth 20 (5) (2008 Aug) 383-5]. ( 29980004 )
2018
8
Horizontal lateral lamella as a risk factor for iatrogenic cerebrospinal fluid leak. Clinical retrospective evaluation of 24 cases. ( 29785412 )
2018
9
Multifaceted Adjunct for Prevention of Cerebrospinal Fluid Leak Following External Ventricular Drain Placement To Minimize Incidence of Infection. ( 29232806 )
2018
10
Posttraumatic cerebrospinal fluid leak associated with an upper cervical meningeal diverticulum. ( 29777885 )
2018
11
Excellent outcomes of large-volume epidural blood patch using an intravenous catheter in 15 consecutive cases with cerebrospinal fluid leak. ( 29966793 )
2018
12
Penetrating trauma causing cerebrospinal fluid leak without nerve root damage. ( 29764819 )
2018
13
Cerebrospinal Fluid Leak at Percutaneous Exit of Ventricular Catheter as a Crucial Risk Factor for External Ventricular Drainage-Related Infection in Adult Neurosurgical Patients. ( 28989043 )
2018
14
Surgical outcomes in the treatment of temporal bone cerebrospinal fluid leak: A systematic review. ( 29636204 )
2018
15
The Management of Cerebrospinal Fluid Leak After Anterior Cervical Decompression Surgery. ( 29451938 )
2018
16
Meningoencephalocele and Cerebrospinal Fluid Leak Complicating Orbital Decompression. ( 29342033 )
2018
17
Combined Endoscopic Transorbital and Endonasal Repair of High Flow Orbital Apex/Middle Fossa Cerebrospinal Fluid Leak with a Nasoseptal Flap. ( 29676403 )
2018
18
Management of a posterior gunshot injury with a floating pedicle and cerebrospinal fluid leak. ( 29525911 )
2018
19
The Surgical Treatment of Posttraumatic Skull Base Defects with Cerebrospinal Fluid Leak. ( 29868329 )
2018
20
Expert's comment concerning Grand Rounds case entitled "Management of a posterior gunshot injury with a floating pedicle and cerebrospinal fluid leak" by A. Bourghli, S. Abouhashem, R. Abo Wali, I. Obeid, L. Boissiere, J. M. Vital, M. Al Sarawan (Eur Spine J; 2018. DOI 10.1007/s00586-018-5537-9). ( 29623493 )
2018
21
Lumbar Drains Decrease the Risk of Postoperative Cerebrospinal Fluid Leak Following Endonasal Endoscopic Surgery for Suprasellar Meningiomas in Patients With High Body Mass Index. ( 29253284 )
2018
22
Cerebrospinal Fluid Leak in Juvenile Nasopharyngeal Angiofibroma-Rare Sequelae of Flutamide-Induced Tumor Shrinkage. ( 30099189 )
2018
23
An Endoscopic Endonasal Repair of Spontaneous Skull Base Cerebrospinal Fluid Leak. ( 30110523 )
2018
24
Visualized ethmoid roof cerebrospinal fluid leak during frontal balloon sinuplasty. ( 30138524 )
2018
25
Cerebrospinal Fluid Leak and Symptomatic Pseudomeningocele After Intradural Spine Surgery. ( 30149160 )
2018
26
Fluoroscopy-Assisted Transnasal Onyx Occlusion of the Eustachian Tube for Lateral Skull Base Cerebrospinal Fluid Leak Repair. ( 30210977 )
2018
27
Corrigendum to "Reconstructive outcome of intraoperative cerebrospinal fluid leak after endoscopic endonasal surgery for tumors involving skull base" [J. Clin. Neurosci. 45 (2017) 227-231]. ( 30287251 )
2018
28
Disturbed Consciousness and Coma: Diagnosis and Management of Intracranial Hypotension Caused by a Spinal Cerebrospinal Fluid Leak. ( 30292664 )
2018
29
Unilateral rhinorrhoea associated with cerebrospinal fluid leak. ( 30301833 )
2018
30
Repair of Cerebrospinal Fluid Leak in Cochlear Implantation. ( 30339594 )
2018
31
The Effect of lumbar drains on spontaneous cerebrospinal fluid leak repair. ( 30351284 )
2018
32
Risk Factors for Cerebrospinal Fluid Leak Following Anterior Cervical Discectomy and Fusion. ( 30379657 )
2018
33
Erratum to "Surgical outcomes in the treatment of temporal bone cerebrospinal fluid leak: A systematic review" [Auris Nasus Larynx 45 (2018) 903-910]. ( 30472083 )
2018
34
Does lumbar drainage reduce postoperative cerebrospinal fluid leak after endoscopic endonasal skull base surgery? A prospective, randomized controlled trial. ( 30485224 )
2018
35
Intraoperative Cerebrospinal Fluid Leak in Extradural Spinal Tumor Surgery. ( 30531655 )
2018
36
A case of delayed hydrocephalus from cerebrospinal fluid leak after resection of a cervical spinal schwannoma. ( 30587875 )
2018
37
Risk factors for cerebrospinal fluid leak in pediatric patients undergoing endoscopic endonasal skull base surgery. ( 28109490 )
2017
38
Cerebrospinal Fluid Leak Rhinorrhea after Systemic Erlotinib Chemotherapy for Metastatic Lung Cancer: A Familiar Problem from an Unfamiliar Culprit. ( 28887281 )
2017
39
Can the Risks of Cerebrospinal Fluid Leak After Vestibular Schwannoma Surgery Be Predicted? ( 27851657 )
2017
40
Diagnosis and Management of Cerebrospinal Fluid Leak in a Panfacial Fracture. ( 28872498 )
2017
41
Spinal Cord Herniation After Cervical Corpectomy with Cerebrospinal Fluid Leak: Case Report and Review of the Literature. ( 28159690 )
2017
42
Spontaneous cerebrospinal fluid leak from the optic canal. ( 29276604 )
2017
43
Endonasal endoscopic management of frontal sinus cerebrospinal fluid leak. ( 29122086 )
2017
44
Risk factors associated with postoperative cerebrospinal fluid leak after endoscopic endonasal skull base surgery. ( 28598276 )
2017
45
Recurrent meningitis with unusually delayed cerebrospinal fluid leak detected by magnetic resonance cisternography. ( 28084280 )
2017
46
Endoscopic Endonasal Cerebrospinal Fluid Leak Repair on the Ventral Midline Skull Base: A Single Neurosurgical Center Experience. ( 28481397 )
2017
47
Locating the site of cerebrospinal fluid leak in a patient with low cerebrospinal fluid pressure. ( 28427771 )
2017
48
Reconstructive outcome of intraoperative cerebrospinal fluid leak after endoscopic endonasal surgery for tumors involving skull base. ( 28765065 )
2017
49
Vaginal Migration of Ventriculoperitoneal Shunt Catheter and Cerebrospinal Fluid Leak as a Complication of Hysterectomy. ( 28461282 )
2017
50
Cranio-cervical junction cerebrospinal fluid leak after microdebrider-assisted adenoidectomy - A rare case report. ( 28802733 )
2017

Variations for Cerebrospinal Fluid Leak

Expression for Cerebrospinal Fluid Leak

Search GEO for disease gene expression data for Cerebrospinal Fluid Leak.

Pathways for Cerebrospinal Fluid Leak

GO Terms for Cerebrospinal Fluid Leak

Cellular components related to Cerebrospinal Fluid Leak according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perinuclear region of cytoplasm GO:0048471 8.62 PTGDS TPPP3

Sources for Cerebrospinal Fluid Leak

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70 SNOMED-CT via HPO
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