Cerebrospinal Fluid Leak

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Cerebrospinal Fluid Leak

MalaCards integrated aliases for Cerebrospinal Fluid Leak:

Name: Cerebrospinal Fluid Leak 52 71 32
Spinal Cerebrospinal Fluid Leak 71
Cerebrospinal Fluid Rhinorrhea 71
Spinal Csf Leak 52
Csf Rhinorrhea 52
Csf Otorrhea 52
Csf Leak 52


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ICD10 32 G96.0
UMLS 71 C0007815 C0023182 C2936821

Summaries for Cerebrospinal Fluid Leak

NIH Rare Diseases : 52 Cerebrospinal fluid (CSF) otorrhea is the leakage of cerebrospinal fluid (CSF) though the ear. It is a rare but very serious condition that requires rapid intervention. Symptoms include leak of clear fluid through the ear, inflammation of the membranes that cover the brain (meningitis ), hearing loss , and seizures . The cause of a spinal fluid leak through the ear is a defect of the bone and meningeal layers covering the brain that separate the subarachnoid space of the brain from the middle ear and mastoid bone (located just behind the ear). The leaks occur after a surgery in the base of the skull, temporal bone fractures, congenital defects of the inner ear , trauma, or they may be spontaneous. Treatment depends on the cause and may include antibiotics , compression dressing and surgery.

MalaCards based summary : Cerebrospinal Fluid Leak, also known as spinal cerebrospinal fluid leak, is related to spontaneous intracranial hypotension and intracranial hypotension, and has symptoms including seizures, vertigo and pain. An important gene associated with Cerebrospinal Fluid Leak is PTGDS (Prostaglandin D2 Synthase). The drugs Budesonide and Thrombin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, bone and brain.

Related Diseases for Cerebrospinal Fluid Leak

Diseases related to Cerebrospinal Fluid Leak via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 199)
# Related Disease Score Top Affiliating Genes
1 spontaneous intracranial hypotension 12.7
2 intracranial hypotension 10.8
3 intracranial hypertension 10.8
4 headache 10.7
5 acoustic neuroma 10.7
6 encephalocele 10.6
7 neurilemmoma 10.6
8 meningitis 10.6
9 hydrocephalus 10.5
10 neuroma 10.5
11 adenoma 10.5
12 pituitary adenoma 10.5
13 meningoencephalocele 10.4
14 meningocele 10.4
15 mollaret meningitis 10.4
16 sleep apnea 10.4
17 craniopharyngioma 10.4
18 empty sella syndrome 10.3
19 bacterial meningitis 10.3
20 otitis media 10.3
21 body mass index quantitative trait locus 1 10.3
22 diabetes insipidus 10.3
23 head injury 10.3
24 pituitary tumors 10.3
25 meningioma, radiation-induced 10.2
26 meningioma, familial 10.2
27 spinal meningioma 10.2
28 papilledema 10.2
29 rhinitis 10.2
30 secretory meningioma 10.2
31 lymphoplasmacyte-rich meningioma 10.2
32 branchiootic syndrome 1 10.2
33 marfan syndrome 10.1
34 migraine with or without aura 1 10.1
35 trigeminal neuralgia 10.1
36 chordoma 10.1
37 intracranial hypertension, idiopathic 10.1
38 ocular motor apraxia 10.1
39 ossification of the posterior longitudinal ligament of spine 10.1
40 allergic rhinitis 10.1
41 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
42 cholesteatoma of middle ear 10.1
43 ehlers-danlos syndrome 10.1
44 spondylosis 10.1
45 olfactory neuroblastoma 10.1
46 spinal stenosis 10.1
47 spinal cord injury 10.1
48 squamous cell papilloma 10.1
49 papilloma 10.1
50 ear malformation 10.1

Graphical network of the top 20 diseases related to Cerebrospinal Fluid Leak:

Diseases related to Cerebrospinal Fluid Leak

Symptoms & Phenotypes for Cerebrospinal Fluid Leak

UMLS symptoms related to Cerebrospinal Fluid Leak:

seizures, vertigo, pain, meningism, reflex, abnormal, neurobehavioral manifestations, neuromuscular manifestations

Drugs & Therapeutics for Cerebrospinal Fluid Leak

Drugs for Cerebrospinal Fluid Leak (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Budesonide Approved Phase 4 51333-22-3 63006 5281004
Thrombin Approved, Investigational Phase 4
3 Respiratory System Agents Phase 4
4 Hormones Phase 4
5 Anti-Asthmatic Agents Phase 4
6 Hormone Antagonists Phase 4
7 glucocorticoids Phase 4
8 Bronchodilator Agents Phase 4
9 Anti-Inflammatory Agents Phase 4
10 Fibrin Tissue Adhesive Phase 4
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
14 Prednisolone acetate Approved, Vet_approved Phase 2, Phase 3 52-21-1
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
Prednisolone hemisuccinate Experimental Phase 2, Phase 3 2920-86-7
17 Gastrointestinal Agents Phase 2, Phase 3
18 Methylprednisolone Acetate Phase 2, Phase 3
19 Antineoplastic Agents, Hormonal Phase 2, Phase 3
20 Antiemetics Phase 2, Phase 3
21 Neuroprotective Agents Phase 2, Phase 3
22 Anti-Bacterial Agents Phase 2, Phase 3
23 Anti-Infective Agents Phase 2, Phase 3
24 Gentamicins Phase 2, Phase 3
25 Protective Agents Phase 2, Phase 3
26 Psychotropic Drugs Phase 2
27 Anti-Anxiety Agents Phase 2
28 GABA Modulators Phase 2
Propofol Approved, Investigational, Vet_approved Phase 1 2078-54-8 4943
Midazolam Approved, Illicit Phase 1 59467-70-8 4192
Dexmedetomidine Approved, Vet_approved Phase 1 113775-47-6 5311068 68602
Ketamine Approved, Vet_approved Phase 1 6740-88-1 3821
33 Analgesics Phase 1
34 Anesthetics, General Phase 1
35 Hypnotics and Sedatives Phase 1
36 Anesthetics, Intravenous Phase 1
37 Neurotransmitter Agents Phase 1
38 Excitatory Amino Acid Antagonists Phase 1
39 Anesthetics, Dissociative Phase 1
Norepinephrine Approved 51-41-2 439260
Tolvaptan Approved 150683-30-0 216237
tannic acid Approved 1401-55-4
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
Morphine Approved, Investigational 57-27-2 5288826
Chitosan Experimental 9012-76-4 71853
48 Hypolipidemic Agents
49 Chelating Agents
50 Lipid Regulating Agents

Interventional clinical trials:

(show top 50) (show all 60)
# Name Status NCT ID Phase Drugs
1 The Impact Of The Addition Of Budesonide To Low-Pressure, High-Volume Saline Sinus Irrigation For Chronic Rhinosinusitis Completed NCT02696850 Phase 4 Budesonide;Saline alone
2 A Prospective Randomized Controlled Study Evaluating the Safety and Efficacy of EVICEL® Used for Suture-Line Sealing in Dura-Mater Closure During Paediatric Neurosurgical Cranial Procedures Recruiting NCT02309645 Phase 4
3 Sphenopalatine Ganglion Nerve Block for Postdural Puncture Headache in Obstetrics Withdrawn NCT03181464 Phase 4 Lidocaine 4%;Placebo
4 A Single-Blinded, Randomized, Controlled Study to Evaluate the Safety and Effectiveness of EVICEL® Fibrin Sealant (Human) Compared to a Hydrogel Sealant as an Adjunct to Sutured Dural Repair Completed NCT02457546 Phase 3
5 A Randomised Controlled Study to Evaluate the Efficacy and Safety of Fibrin Sealant, Vapour Heated, Solvent/Detergent Treated FS VH S/D 500 S-apr (Tisseel) Compared to DuraSeal Dural Sealant as an Adjunct to Sutured Dural Repair in Cranial Surgery. Completed NCT02891070 Phase 3 FS VH S/D 500 s-apr
6 TachoSil® Versus Current Practice in Dura Sealing Techniques for the Prevention of Post-operative Cerebrospinal Fluid (CSF) Leaks in Patients Undergoing Skull Base Surgery: An Open Label, Randomised, Controlled, Multi-centre, Parallel Group Efficacy and Safety Trial. Completed NCT01355627 Phase 3
7 A Randomized, Controlled Study to Evaluate the Safety and Effectiveness of EVICEL as an Adjunct to Sutured Dural Repair Completed NCT01174992 Phase 2, Phase 3
8 A Prospective, Randomized, Controlled, Single Blinded, Study to Evaluate the Safety and Effectiveness of Bioseal as an Adjunct to Sutured Dural Repair Completed NCT03110783 Phase 3
9 Effectiveness of Transtympanic Steroids in Unilateral Ménière's Disease: a Randomised Controlled Double-Blind Trial Completed NCT00802529 Phase 2, Phase 3 Methylprednisolone;Gentamicin
10 A Pivotal Clinical Trial Examining the Safety and Effectiveness of the Adherus Dural Sealant System When Used as a Dural Sealant in Cranial Procedures Completed NCT01158378 Phase 3
11 A Prospective, Multi-Center, Randomized Controlled Study to Compare the Spinal Sealant System as an Adjunct to Sutured Dural Repair With Standard of Care Methods During Spinal Surgery Completed NCT00458354 Phase 3
12 Evaluating the Effect of Acetazolamide Administration and Prone Positioning Following Lumbosacral Spinal Surgery in Preventing Cerebro Spinal Fluid Leakage and Collection and Wound Dehiscence in Children. Unknown status NCT01867268 Phase 2 Acetazolamide
13 Periprocedural Sedation for the Prevention of Post Dural Puncture Headache Unknown status NCT01503788 Phase 2 Midazolam
14 Pilot Study of Acetazolamide to Prevent Post Operative Cerebrospinal Fluid (CSF) Leak in Patients Undergoing Endoscopic Skull Base Surgery Not yet recruiting NCT04351061 Phase 2 Acetazolamide
15 A Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for Treatment of Cerebrospinal Fluid Leaks in Spontaneous Intracranial Hypotension. Suspended NCT03276975 Phase 2 TISSEEL
16 Pilot Study of Acetazolamide to Prevent Post Operative Cerebrospinal Fluid (CSF) Leak in Patients Undergoing Endoscopic Skull Base Surgery Withdrawn NCT02902133 Phase 2 Acetazolamide
17 Spreading Depolarization and Ketamine Suppression Completed NCT02501941 Phase 1 ketamine
18 Study to Compare 2 Minimally Invasive Fetal Neural Tube Defect Repair Techniques: Repair Using Durepair Patch vs. Repair Without Durepair Patch Recruiting NCT03794011 Phase 1
19 Flat Bed Rest vs. Immediate Mobilisation After Incidental Durotomy During Lumbar Spinal Surgery: A Prospective Randomised Trial Unknown status NCT02927782
20 Continuous Spinal Anesthesia Versus Combined Spinal Epidural Block for Major Orthopedic Surgeries. Study Prospective and Randomized. Unknown status NCT00616044
21 Skull Base Reconstruction After Endonasal Cranio-endoscopic Resection Using Autologus Grafts Unknown status NCT03448614
22 Prospective Study for Improvement in Outcomes Following Draf III/Endoscopic Modified Lothrop Procedure Using a Porcine Intestinal Submucosal Graft Unknown status NCT02981017
24 A Prospective, Multi-Center, Randomized Controlled Study to Compare the Spinal Sealant System as an Adjunct to Sutured Dural Repair With Standard of Care Methods During Spinal Surgery Completed NCT00444067
25 International Opinion Study on Peri-operative Cerebrospinal Fluid Leaks Management After Endoscopic Skull Base Surgery Completed NCT04124523
26 Chitosan Scaffold for Sellar Floor Repair in Endoscopic Endonasal Transsphenoidal Surgery Completed NCT03280849
27 A Prospective, Open, Multi-center, Single-arm Study of the Performance and Safety of I-020805 in the Prevention of Cerebrospinal Fluid Leakage Following Elective Cranial Surgery Completed NCT01295619
28 A Prospective, Multi-Center, Randomized Controlled Study to Compare the Spinal Sealant System as an Adjunct to Sutured Dural Repair With Standard of Care Methods During Spinal Surgery Completed NCT00594035
29 Auftreten Von Okkultem Asymptomatischem Liqourverlust Nach Nebenhöhlenoperationen Eine Prospektive Kohortenstudie Completed NCT02382692
30 Cone Beam CT (CS 9300) for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower Dose Completed NCT01855425
31 Predictive Factors of Re-craniotomy and Major Non-neurological Complications in Elective Neurosurgery: A Prospective Cohort Study Completed NCT03910556 Propofol
32 Incidence of Post-Dural Puncture Headache Following Unintentional Dural Puncture: A Randomized Trial of Intrathecal Morphine Versus Saline Completed NCT01977898 Morphine;Saline
33 A Multi-Center, Randomized, Controlled, Trial of Cerebrospinal Fluid Drainage (CSFD) in Acute Spinal Cord Injury Completed NCT02495545
34 A New Cochlear Implant Electrode With A "Cork" Type Stopper For Inner Ear Malformations Completed NCT02011867
35 Evaluation of a Simulation Based Workshop to Enhance Learning of Insertion and Management of CSF Drainage Catheters in an Anesthesia Residency Program Completed NCT03545984
36 Preemptive Analgesia for Postoperative Pain Relief in Thoraco-lumbo-sacral Spine Surgery: a Double-blinded Randomized Controlled Trial Completed NCT02968862
37 Non-Missile Penetrating Brain Injuries, Cases Registry in Sohag University Hospital Completed NCT03768778
38 Effectiveness of a Multimodal Prophylactic Strategy to Treat Post-dural Puncture Headache: A Retrospective Study Completed NCT03790124
39 15-Degree Reverse Trendelenburg Position for FESS Completed NCT01442740
40 Comparison of the Posterior Septectomy and Stamm Approach to Endoscopic Pituitary Adenoma Resection: A Randomized, Single-blind Trial Completed NCT01689064
41 Transcranial Doppler Role in Prediction of Post-dural Puncture Headache in Parturients Undergoing Elective Caesarean Section Completed NCT03464253
42 Comparison of the Vasopressin-2 Antagonist Tolvaptan and Fluid Restriction in the Treatment of Hyponatremia Following Pituitary Surgery Completed NCT04119206
43 A Feasibility Clinical Trial to Evaluate High Frequency Spinal Cord Stimulation for the Treatment of Patients With Chronic Migraine Completed NCT01653340
44 Post-market Clinical Data Collection Plan for the Biodesign® Dural and Duraplasty Grafts Recruiting NCT04057157
45 Single-arm, Open-label, Multicenter Study to Evaluate the Safety and Performance of Dura Sealant Patch in Reducing CSF Leakage Following Elective Cranial Surgery Recruiting NCT03566602
46 A Randomised Controlled Study of Endoscopic Sinus Surgery for Recurrent Acute Rhinosinusitis Recruiting NCT04241016
47 Nasal Packing Following Endoscopic Endonasal Pituitary Resection Recruiting NCT03677713
48 A Prospective, Randomized, Controlled Multi-center Study of ArtiFascia® Dural Repair Patch Compared With Commercially Available Dural Substitutes- NEOART Study. Recruiting NCT04145544
49 Multimodal Sonographic Monitoring of Cerebral Perfusion, Ventricle Seize and Optic Nerve Diameter During Weaning of Cerebrospinal Fluid Drainage Catheters: a Single Centre Observational Trial Recruiting NCT02408757
50 Simultaneous Cochlear Implantation During Translabyrinthine Resection of Vestibular Schwannoma Recruiting NCT03958006

Search NIH Clinical Center for Cerebrospinal Fluid Leak

Genetic Tests for Cerebrospinal Fluid Leak

Anatomical Context for Cerebrospinal Fluid Leak

MalaCards organs/tissues related to Cerebrospinal Fluid Leak:

Pituitary, Bone, Brain, Spinal Cord, Kidney, Testes, Cerebellum

Publications for Cerebrospinal Fluid Leak

Articles related to Cerebrospinal Fluid Leak:

(show top 50) (show all 1755)
# Title Authors PMID Year
Simultaneous Midface Advancement and Orthognathic Surgery: A Powerful Technique for Managing Midface Hypoplasia and Malocclusion. 61
32459778 2020
Spontaneous cerebrospinal fluid leak via foramen rotundum in a non-obese male presented as pseudo-Chiari malformation type I: a case report and literature review. 61
32571109 2020
A Revised Surgical Approach to Induce Endolymphatic Hydrops in the Guinea Pig. 61
32568243 2020
Audiometric Outcomes and Middle Ear Disease following Cerebrospinal Fluid Leak Repair. 61
32204657 2020
Chemotherapy associated dural sinus thrombosis presenting as a cerebrospinal fluid leak. 61
32487533 2020
Comparison of translabyrinthine and retrosigmoid approach for treating vestibular schwannoma: A meta-analysis. 61
32540713 2020
Challenges, Learning Curve, and Safety of Endoscopic Endonasal Surgery of Sellar-Suprasellar Lesions in a Community Hospital. 61
32298827 2020
Traumatic Nonmissile Penetrating Transnasal Anterior Skull Base Fracture and Brain Injury with Cerebrospinal Fluid Leak: Intraoperative Leak Detection and an Effective Reconstruction Procedure for a Localized Skull Base Defect Especially After Coronavirus Disease 2019 Outbreak. 61
32497852 2020
Cranial Vault Reconstruction and Evacuation of Hemorrhage After a Bifrontal Gunshot Wound to the Brain. 61
32247791 2020
Endoscopic "Quick" Septoplasty in Preservation Rhinoplasty. 61
32541536 2020
Cerebrospinal fluid leaks secondary to dural tears: a review of etiology, clinical evaluation, and management. 61
32242448 2020
Postoperative Cerebrospinal Fluid Leak After Lumbar Total Disc Replacement: A Diagnostic and Management Challenge. 61
32035203 2020
Dural venous sinus thrombosis after cerebellopontine angle surgery: Should it be treated? 61
32173152 2020
Spontaneous Intracranial Hypotension May Be an Under-recognized Cause of Endolymphatic Hydrops. 61
32472922 2020
The Monobloc Distraction With Facial Bipartition: Outcomes of Simultaneous Multidimensional Facial Movement Compared With Monobloc Distraction or Facial Bipartition Alone. 61
32049754 2020
Surgical Management of Symptomatic Boxing-Induced Spinal Cerebrospinal Fluid Leak After Failed Epidural Blood Patch. 61
32376374 2020
Clinical Outcomes of Infratentorial Meningioma Surgery in a Developing Country. 61
32032796 2020
Pituitary Apoplexy Case Series: Outcomes After Endoscopic Endonasal Transsphenoidal Surgery at a Single Tertiary Center. 61
32032792 2020
Total Endoscopic Ear Surgery in management of cochleocele: A case series. 61
32480139 2020
The Utility of Computed Tomography and Intrathecal Fluorescein in the Management of Cerebrospinal Fluid Leak. 61
31856587 2020
Spontaneous Nasal Cerebrospinal Fluid Leak Repaired With Single-Layer Mucoperichondrial Graft: Long-term Results. 61
31928352 2020
Intrathecal blood injection: a case report of a rare complication of an epidural blood patch. 61
32404065 2020
Trends in endoscopic and microscopic transsphenoidal surgery: a survey of the international society of pituitary surgeons between 2010 and 2020. 61
32441022 2020
Syringo-Subarachnoid Shunt Placement: A Minimally Invasive Technique Using Fixed Tubular Retractors-Three Case Reports and Literature Review. 61
32355617 2020
[Subtotal petrosectomy - indications, surgical technique, experiences in Pécs]. 61
32223420 2020
Recurrent Meningitis in Congenital Inner Ear Malformation. 61
32320299 2020
Long-Term Outcomes from Blind Sac Closure of the External Auditory Canal: Our Institutional Experience in Different Pathologies. 61
32401203 2020
A Simplified Approach to Myelomeningocele Defect Repair. 61
32349084 2020
Risk factors and outcomes of cerebrospinal fluid leak related to endoscopic pituitary adenoma surgery. 61
32319826 2020
Application of the Three Points and Three Lines Method to Accurately Open the Sellar Floor in Microscopic Transsphenoidal Surgery of Pituitary Adenomas. 61
32339742 2020
Spinal cerebrospinal fluid leak in the context of pars interarticularis fracture. 61
32349710 2020
Cerebrospinal fluid leak presented with the C1-C2 sign caused by spinal canal stenosis: a case report. 61
32326909 2020
Traumatic pneumorrhachis: systematic review and an illustrative case. 61
32307638 2020
Trends in Age of Cochlear Implant Recipients, and the Impact on Perioperative Complication Rates. 61
32176121 2020
Spinal Cord Stimulator Paddle Lead Surgery Complicated by Cerebrospinal Fluid Leak and Fistula Formation. 61
32399352 2020
The 'mushroom': a simple and safe technique to avoid cerebrospinal fluid leak after endoscopic third ventriculostomy. 61
31964159 2020
Cervical Intradural Disc Herniation: Case Report and Operative Video. 61
32377485 2020
Unique Far-Lateral Closure Technique: Technical Note. 61
31236599 2020
Near Total Versus Gross Total Resection of Large Vestibular Schwannomas: Facial Nerve Outcome. 61
32330283 2020
Developing a Spinal CSF Leak Program in a Multihospital Network. 61
32305133 2020
Effect of Intraoperative Lumbar Drainage on Gross Total Resection and Cerebrospinal Fluid Leak Rates in Endoscopic Transsphenoidal Surgery of Pituitary Macroadenomas. 61
31881340 2020
32524018 2020
Complications of anterior cervical spine surgery: a systematic review of the literature. 61
32309668 2020
A large case series of temporal bone fractures at a UK major trauma centre with an evidence-based management protocol. 61
32122408 2020
Currarino syndrome presenting as a cerebrospinal fluid leak from the dermal sinus tract: case report. 61
32114544 2020
Expanded transnasal approaches to the skull base in the Middle East: Where do we stand? 61
32241167 2020
Anterior Cervical Discectomy and Fusion in the Outpatient Ambulatory Surgery Setting: Analysis of 2000 Consecutive Cases. 61
31819994 2020
Investigation of Skull-Based Cerebrospinal Fluid Leak Repair: A Single-Institution Comprehensive Study of 116 Cases Over 10 Years. 61
31604132 2020
Outcome of Endoscopic Endonasal Surgery in Pediatric Craniopharyngiomas. 61
31629927 2020
Approaching the Sella through the Nonpneumatized Sphenoid in Pediatric Patients. 61
32021750 2020

Variations for Cerebrospinal Fluid Leak

Expression for Cerebrospinal Fluid Leak

Search GEO for disease gene expression data for Cerebrospinal Fluid Leak.

Pathways for Cerebrospinal Fluid Leak

GO Terms for Cerebrospinal Fluid Leak

Cellular components related to Cerebrospinal Fluid Leak according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perinuclear region of cytoplasm GO:0048471 8.62 TPPP3 PTGDS

Sources for Cerebrospinal Fluid Leak

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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