MCID: CRB040
MIFTS: 42

Cerebrum Cancer

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Cerebrum Cancer

MalaCards integrated aliases for Cerebrum Cancer:

Name: Cerebrum Cancer 12 15
Malignant Neoplasm of Cerebrum 73
Neoplasm of Cerebrum 12
Tumor of Cerebrum 12
Cerebral Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:368
ICD9CM 35 191.8
NCIt 50 C4874

Summaries for Cerebrum Cancer

Disease Ontology : 12 A supratentorial cancer that is located in the cerebrum.

MalaCards based summary : Cerebrum Cancer, also known as malignant neoplasm of cerebrum, is related to cerebral ventricle cancer and parietal lobe neoplasm. An important gene associated with Cerebrum Cancer is TP53 (Tumor Protein P53), and among its related pathways/superpathways are ERK Signaling and Human cytomegalovirus infection. Affiliated tissues include lung, brain and bone, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Cerebrum Cancer

Diseases related to Cerebrum Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 204)
# Related Disease Score Top Affiliating Genes
1 cerebral ventricle cancer 32.0 GFAP SYP TP53
2 parietal lobe neoplasm 11.0
3 cerebral lymphoma 11.0
4 brain ependymoma 10.4 EGFR TP53
5 cerebral convexity meningioma 10.4 GFAP TP53
6 enchondroma 10.4 IDH1 IDH2
7 rare adenocarcinoma of the breast 10.4 AKT1 TP53
8 anaplastic ganglioglioma 10.4 GFAP NES
9 pharynx squamous cell carcinoma 10.4 AKT1 PTEN
10 preretinal fibrosis 10.4 GFAP VEGFA
11 mucinous stomach adenocarcinoma 10.4 PTEN VEGFA
12 bladder squamous cell carcinoma 10.4 CDKN2A TP53
13 malignant peritoneal mesothelioma 10.4 CDKN2A EGFR
14 lung combined type small cell carcinoma 10.4 GFAP SYP
15 desmoplastic infantile ganglioglioma 10.4 GFAP SYP
16 sinonasal undifferentiated carcinoma 10.4 IDH2 SYP
17 uterine carcinosarcoma 10.4 EGFR PTEN TP53
18 infiltrating angiolipoma 10.3 CDKN2A VEGFA
19 ductal carcinoma in situ 10.3 AKT1 EGFR TP53
20 estrogen-receptor positive breast cancer 10.3 AKT1 EGFR TP53
21 malignant glandular tumor of peripheral nerve sheath 10.3 NF1 SYP
22 prostate disease 10.3 AKT1 PTEN TP53
23 colorectal adenocarcinoma 10.3 EGFR TP53 VEGFA
24 bile duct cancer 10.3 EGFR TP53 VEGFA
25 differentiated thyroid carcinoma 10.3 EGFR TP53 VEGFA
26 oligoastrocytoma 10.3 GFAP IDH2 MGMT
27 intracranial chondrosarcoma 10.3 IDH1 IDH2 TP53
28 mixed glioma 10.3 GFAP IDH1 TP53
29 gonadal disease 10.3 AKT1 TP53 VEGFA
30 oral cancer 10.3 CDKN2A EGFR TP53
31 protoplasmic astrocytoma 10.3 GFAP IDH2 TP53
32 cerebellar astrocytoma 10.3 IDH1 KIAA1549 TP53
33 gliofibroma 10.3 GFAP NF1 TP53
34 bladder disease 10.3 AKT1 CDKN2A TP53
35 tongue squamous cell carcinoma 10.3 AKT1 CDKN2A TP53
36 gemistocytic astrocytoma 10.3 GFAP IDH2 PTEN
37 ependymoblastoma 10.3 GFAP NES TP53
38 adult oligodendroglioma 10.3 IDH1 IDH2 NF1
39 frontal convexity meningioma 10.3 GFAP TP53
40 ocular cancer 10.3 CDKN2A SOX2 TP53
41 interval angle-closure glaucoma 10.3 IDH1 IDH2
42 extraventricular neurocytoma 10.3 GFAP IDH1 SYP
43 cellular ependymoma 10.3 GFAP SYP TP53
44 hemangioblastoma 10.3 GFAP SYP VEGFA
45 cell type benign neoplasm 10.3 CDKN2A SYP TP53
46 cerebral neuroblastoma 10.3 GFAP SYP TP53
47 central nervous system germ cell tumor 10.3 GFAP NES SOX2
48 soft tissue sarcoma 10.3 EGFR TP53 VEGFA
49 choroid plexus cancer 10.3 ATRX GFAP TP53
50 gastric adenosquamous carcinoma 10.3 CDKN2A PROM1 TP53

Graphical network of the top 20 diseases related to Cerebrum Cancer:



Diseases related to Cerebrum Cancer

Symptoms & Phenotypes for Cerebrum Cancer

GenomeRNAi Phenotypes related to Cerebrum Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.92 EGFR
2 Decreased viability GR00221-A-1 9.92 AKT1 CDKN2A EGFR NF1 SOX2
3 Decreased viability GR00221-A-2 9.92 AKT1 NF1
4 Decreased viability GR00221-A-3 9.92 AKT1 CDKN2A
5 Decreased viability GR00221-A-4 9.92 AKT1 CDKN2A EGFR NF1 SOX2
6 Decreased viability GR00402-S-2 9.92 AKT1 CDKN2A EGFR NF1 SOX2
7 Decreased p24 protein expression GR00163-A-1 9.46 AKT1 EGFR H3F3A IDH1
8 Decreased sensitivity to paclitaxel GR00112-A-0 8.96 NF1 PTEN

MGI Mouse Phenotypes related to Cerebrum Cancer:

46 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.42 AKT1 ATRX CDKN2A GFAP KIAA1549 NF1
2 cellular MP:0005384 10.4 AKT1 ATRX CDKN2A EGFR GFAP H3F3B
3 growth/size/body region MP:0005378 10.4 AKT1 ATRX CDKN2A EGFR GFAP H3F3B
4 mortality/aging MP:0010768 10.37 AKT1 ATRX CDKN2A EGFR GFAP H3F3B
5 cardiovascular system MP:0005385 10.34 AKT1 ATRX CDKN2A EGFR GFAP IDH2
6 homeostasis/metabolism MP:0005376 10.33 AKT1 CDKN2A EGFR GFAP IDH1 KIAA1549
7 immune system MP:0005387 10.28 AKT1 CDKN2A EGFR GFAP IDH1 KIAA1549
8 embryo MP:0005380 10.27 AKT1 ATRX CDKN2A EGFR H3F3B NF1
9 nervous system MP:0003631 10.25 AKT1 ATRX CDKN2A EGFR GFAP NF1
10 neoplasm MP:0002006 10.23 AKT1 CDKN2A EGFR IDH2 MGMT NF1
11 endocrine/exocrine gland MP:0005379 10.22 AKT1 CDKN2A EGFR MGMT NF1 PTEN
12 digestive/alimentary MP:0005381 10.19 CDKN2A EGFR GFAP NF1 PTEN SOX2
13 muscle MP:0005369 10.18 AKT1 CDKN2A EGFR GFAP NF1 OLIG2
14 integument MP:0010771 10.13 AKT1 CDKN2A EGFR NF1 PTEN SOX2
15 normal MP:0002873 10.11 AKT1 EGFR GFAP H3F3B NF1 PROM1
16 liver/biliary system MP:0005370 10.05 AKT1 CDKN2A EGFR NF1 PTEN TP53
17 no phenotypic analysis MP:0003012 10.01 CDKN2A EGFR MGMT OLIG2 PROM1 SOX2
18 reproductive system MP:0005389 9.91 AKT1 ATRX CDKN2A EGFR H3F3B PTEN
19 respiratory system MP:0005388 9.9 AKT1 CDKN2A EGFR IDH1 MGMT NF1
20 pigmentation MP:0001186 9.87 CDKN2A EGFR NF1 PROM1 PTEN SOX2
21 skeleton MP:0005390 9.65 AKT1 CDKN2A EGFR IDH1 NF1 OLIG2
22 vision/eye MP:0005391 9.36 ATRX CDKN2A EGFR GFAP NF1 OLIG2

Drugs & Therapeutics for Cerebrum Cancer

Search Clinical Trials , NIH Clinical Center for Cerebrum Cancer

Genetic Tests for Cerebrum Cancer

Anatomical Context for Cerebrum Cancer

MalaCards organs/tissues related to Cerebrum Cancer:

41
Lung, Brain, Bone, Colon, Tongue, Spinal Cord, Cerebellum

The Foundational Model of Anatomy Ontology organs/tissues related to Cerebrum Cancer:

19
The Cerebrum

Publications for Cerebrum Cancer

Articles related to Cerebrum Cancer:

# Title Authors Year
1
Interplay between parkin and p53 governs a physiological homeostasis that is disrupted in Parkinson's disease and cerebral cancer. ( 24008413 )
2014

Variations for Cerebrum Cancer

Expression for Cerebrum Cancer

Search GEO for disease gene expression data for Cerebrum Cancer.

Pathways for Cerebrum Cancer

Pathways related to Cerebrum Cancer according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 AKT1 CDKN2A EGFR GFAP H3F3A H3F3B
2
Show member pathways
13.01 AKT1 CDKN2A EGFR PTEN TP53 VEGFA
3
Show member pathways
12.78 AKT1 CDKN2A EGFR PTEN TP53 VEGFA
4 12.72 AKT1 EGFR NF1 TP53 VEGFA
5
Show member pathways
12.72 AKT1 CDKN2A EGFR PTEN TP53
6 12.72 AKT1 CDKN2A EGFR PTEN TP53 VEGFA
7
Show member pathways
12.54 AKT1 CDKN2A EGFR NF1 PTEN TP53
8 12.42 CDKN2A EGFR PTEN TP53 VEGFA
9 12.25 AKT1 EGFR TP53 VEGFA
10 12.21 H3F3A H3F3B PROM1 TP53
11
Show member pathways
12.17 AKT1 EGFR PTEN VEGFA
12
Show member pathways
12.15 AKT1 EGFR PTEN TP53
13 12.12 AKT1 EGFR TP53 VEGFA
14 12.09 AKT1 EGFR PTEN TP53
15 12.09 AKT1 CDKN2A PTEN TP53
16 11.99 NES PROM1 SOX2 VEGFA
17 11.92 AKT1 EGFR NF1 PTEN TP53 VEGFA
18 11.87 AKT1 CDKN2A PTEN TP53
19
Show member pathways
11.86 AKT1 EGFR H3F3A H3F3B TP53
20 11.84 AKT1 SOX2 TP53 VEGFA
21 11.82 AKT1 PTEN TP53
22 11.81 AKT1 EGFR PTEN
23 11.77 AKT1 PTEN TP53
24 11.7 AKT1 CDKN2A TP53
25
Show member pathways
11.7 AKT1 CDKN2A TP53
26 11.6 CDKN2A EGFR TP53 VEGFA
27 11.55 AKT1 CDKN2A EGFR MGMT NF1 PTEN
28 11.54 AKT1 PTEN TP53
29 11.53 CDKN2A TP53 VEGFA
30 11.52 AKT1 ATRX PTEN TP53
31 11.49 AKT1 TP53 VEGFA
32 11.49 CDKN2A EGFR TP53
33 11.45 EGFR NF1 VEGFA
34 11.41 AKT1 PTEN TP53
35 11.37 AKT1 EGFR IDH1 PTEN TP53
36 11.17 EGFR H3F3A H3F3B TP53
37 11.15 AKT1 EGFR PROM1
38 11.06 GFAP NES OLIG2 PROM1 SOX2 SYP
39
Show member pathways
10.79 IDH1 IDH2

GO Terms for Cerebrum Cancer

Cellular components related to Cerebrum Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Barr body GO:0001740 8.96 H3F3A H3F3B
2 nuclear chromosome GO:0000228 8.8 ATRX H3F3A H3F3B

Biological processes related to Cerebrum Cancer according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.99 AKT1 EGFR MGMT PTEN TP53 VEGFA
2 brain development GO:0007420 9.95 H3F3A H3F3B NES NF1
3 positive regulation of apoptotic process GO:0043065 9.95 AKT1 CDKN2A NF1 PTEN TP53
4 multicellular organism growth GO:0035264 9.83 ATRX H3F3A H3F3B
5 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.83 AKT1 EGFR VEGFA
6 negative regulation of protein kinase activity GO:0006469 9.82 AKT1 CDKN2A NF1
7 positive regulation of endothelial cell proliferation GO:0001938 9.81 AKT1 NF1 VEGFA
8 response to organic cyclic compound GO:0014070 9.8 EGFR IDH1 MGMT PTEN
9 Ras protein signal transduction GO:0007265 9.79 CDKN2A NF1 TP53
10 response to hormone GO:0009725 9.76 AKT1 H3F3A H3F3B
11 cellular response to hypoxia GO:0071456 9.73 AKT1 PTEN TP53 VEGFA
12 mammary gland epithelial cell differentiation GO:0060644 9.67 AKT1 MGMT
13 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 9.67 MGMT SOX2
14 replicative senescence GO:0090399 9.66 CDKN2A TP53
15 negative regulation of cell size GO:0045792 9.64 AKT1 PTEN
16 forebrain morphogenesis GO:0048853 9.63 NF1 PTEN
17 NADP metabolic process GO:0006739 9.62 IDH1 IDH2
18 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.62 EGFR TP53
19 obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.58 CDKN2A PTEN
20 DNA replication-independent nucleosome assembly GO:0006336 9.58 ATRX H3F3A H3F3B
21 obsolete positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031659 9.57 AKT1 EGFR
22 isocitrate metabolic process GO:0006102 9.56 IDH1 IDH2
23 cellular response to decreased oxygen levels GO:0036294 9.54 AKT1 PTEN
24 pericentric heterochromatin assembly GO:0031508 9.52 H3F3A H3F3B
25 regulation of centromere complex assembly GO:0090230 9.48 H3F3A H3F3B
26 response to UV-A GO:0070141 9.46 AKT1 EGFR
27 positive regulation of cell growth GO:0030307 9.46 AKT1 EGFR H3F3A H3F3B
28 cell proliferation GO:0008283 9.43 AKT1 EGFR H3F3A H3F3B PTEN TP53
29 glyoxylate cycle GO:0006097 9.37 IDH1 IDH2
30 negative regulation of chromosome condensation GO:1902340 9.32 H3F3A H3F3B
31 telomeric heterochromatin assembly GO:0031509 9.26 H3F3A H3F3B
32 osteoblast differentiation GO:0001649 9.02 AKT1 H3F3A H3F3B NF1 SOX2
33 positive regulation of transcription by RNA polymerase II GO:0045944 10.14 AKT1 ATRX CDKN2A EGFR SOX2 TP53
34 multicellular organism development GO:0007275 10.14 AKT1 EGFR NES OLIG2 SOX2 TP53
35 nervous system development GO:0007399 10.04 AKT1 NES OLIG2 PTEN VEGFA
36 positive regulation of gene expression GO:0010628 10 AKT1 CDKN2A PTEN TP53 VEGFA

Molecular functions related to Cerebrum Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.77 EGFR H3F3A H3F3B TP53 VEGFA
2 protein kinase binding GO:0019901 9.65 AKT1 CDKN2A EGFR PTEN TP53
3 nitric-oxide synthase regulator activity GO:0030235 9.32 AKT1 EGFR
4 identical protein binding GO:0042802 9.23 AKT1 EGFR GFAP IDH1 PTEN SYP
5 isocitrate dehydrogenase (NADP+) activity GO:0004450 9.16 IDH1 IDH2
6 isocitrate dehydrogenase activity GO:0004448 8.96 IDH1 IDH2

Sources for Cerebrum Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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