MCID: CRB040
MIFTS: 29

Cerebrum Cancer

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Cerebrum Cancer

MalaCards integrated aliases for Cerebrum Cancer:

Name: Cerebrum Cancer 12 15
Malignant Neoplasm of Cerebrum 70
Neoplasm of Cerebrum 12
Tumor of Cerebrum 12
Cerebral Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:368
ICD9CM 34 191.8
NCIt 50 C4874
SNOMED-CT 67 126953009 188300006
UMLS 70 C0153642 C0346903 C1263885

Summaries for Cerebrum Cancer

Disease Ontology : 12 A supratentorial cancer that is located in the cerebrum.

MalaCards based summary : Cerebrum Cancer, also known as malignant neoplasm of cerebrum, is related to cerebral ventricle cancer and parietal lobe neoplasm. An important gene associated with Cerebrum Cancer is SYP (Synaptophysin), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include cerebrum, spinal cord and lung, and related phenotypes are Increased proliferation and growth/size/body region

Related Diseases for Cerebrum Cancer

Diseases related to Cerebrum Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 256)
# Related Disease Score Top Affiliating Genes
1 cerebral ventricle cancer 28.8 ZFTA YAP1 TP53 TAF12 SYP SMARCB1
2 parietal lobe neoplasm 11.0
3 cerebral lymphoma 11.0
4 malignant melanocytic neoplasm of the peripheral nerve sheath 10.5 SYP ENO2
5 anal neuroendocrine tumor 10.5 SYP ENO2
6 monosomy 22 10.5 SMARCB1 NF2
7 rela fusion-positive ependymoma 10.5 ZFTA RELA
8 neuronal intestinal dysplasia, type b 10.5 SYP ENO2
9 sarcomatoid transitional cell carcinoma 10.5 TP53 SYP
10 large cell carcinoma with rhabdoid phenotype 10.5 SMARCB1 ENO2
11 sinonasal undifferentiated carcinoma 10.5 SYP ENO2
12 auditory system benign neoplasm 10.5 SYP ENO2
13 papillary tumor of the pineal region 10.5 SYP ENO2
14 lung combined type small cell carcinoma 10.5 SYP GFAP
15 auditory system cancer 10.5 SYP ENO2
16 cloacogenic carcinoma 10.5 SYP ENO2
17 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.5 SYP ENO2
18 intracranial primitive neuroectodermal tumor 10.5 SYP ENO2
19 nodular prostate 10.5 SYP ENO2
20 ampulla of vater benign neoplasm 10.5 SYP ENO2
21 appendix carcinoid tumor 10.5 SYP ENO2
22 posterior pituitary gland neoplasm 10.5 SMARCB1 GFAP
23 carotid body cancer 10.5 SYP ENO2
24 intracranial cysts 10.5 GFAP ENO2
25 gallbladder small cell carcinoma 10.5 SYP ENO2
26 ureter small cell carcinoma 10.5 SYP ENO2
27 middle ear adenoma 10.5 SYP ENO2
28 primitive neuroectodermal tumor of the cervix uteri 10.5 GFAP ENO2
29 suprasellar meningioma 10.5 NF2 GFAP
30 internal auditory canal lipoma 10.4 SMARCB1 IDH1
31 urethra transitional cell carcinoma 10.4 TP53 GFAP
32 peripheral nerve schwannoma 10.4 SMARCB1 NF2
33 urinary bladder small cell neuroendocrine carcinoma 10.4 SYP ENO2
34 gastric small cell carcinoma 10.4 SYP ENO2
35 jejunal neoplasm 10.4 SYP ENO2
36 cerebral falx meningioma 10.4 NF2 ENO2
37 sensory organ benign neoplasm 10.4 SYP ENO2
38 third ventricle chordoid glioma 10.4 OLIG2 GFAP
39 ovarian large-cell neuroendocrine carcinoma 10.4 SYP ENO2
40 gastric hemangioma 10.4 SYP ENO2
41 rhabdoid tumor predisposition syndrome 1 10.4 TP53 SMARCB1
42 optic nerve sheath meningioma 10.4 SMARCB1 NF2
43 psammomatous meningioma 10.4 NF2 ENO2
44 myoblastoma 10.4 SYP ENO2
45 pineal parenchymal tumor of intermediate differentiation 10.4 SYP ENO2
46 chiari malformation 10.4 SYP GFAP
47 cerebral convexity meningioma 10.4 NF2 IDH1
48 schwannoma of twelfth cranial nerve 10.4 SMARCB1 NF2
49 cutaneous ganglioneuroma 10.4 SYP ENO2
50 hypoglossal nerve disease 10.4 SMARCB1 NF2

Graphical network of the top 20 diseases related to Cerebrum Cancer:



Diseases related to Cerebrum Cancer

Symptoms & Phenotypes for Cerebrum Cancer

GenomeRNAi Phenotypes related to Cerebrum Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.8 NF2 SMARCB1 TP53

MGI Mouse Phenotypes related to Cerebrum Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.13 CBY1 ENO2 GFAP IDH1 KCNJ13 MYCN
2 mortality/aging MP:0010768 10.07 CBY1 GFAP IDH1 KCNJ13 MGMT MYCN
3 embryo MP:0005380 10.02 CBY1 KCNJ13 MYCN NF2 RELA SMARCB1
4 nervous system MP:0003631 10 ENO2 GFAP MGMT MYCN NELL2 NF2
5 respiratory system MP:0005388 9.7 CBY1 ENO2 IDH1 KCNJ13 MGMT MYCN
6 vision/eye MP:0005391 9.28 GFAP MYCN NF2 OLIG2 RELA RTBDN

Drugs & Therapeutics for Cerebrum Cancer

Search Clinical Trials , NIH Clinical Center for Cerebrum Cancer

Genetic Tests for Cerebrum Cancer

Anatomical Context for Cerebrum Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Cerebrum Cancer:

19
Cerebrum

MalaCards organs/tissues related to Cerebrum Cancer:

40
Spinal Cord, Lung, Pineal, Brain, Breast, Prostate, Cervix

Publications for Cerebrum Cancer

Articles related to Cerebrum Cancer:

# Title Authors PMID Year
1
Primitive neuroectodermal tumor of cerebrum with adipose tissue. 61
11175648 2001
2
[A clinicopathological analysis of primitive neuroectodermal tumors of the CNS]. 61
11244998 1998
3
Adipose tissue and smooth muscle in a primitive neuroectodermal tumor of cerebrum. 61
8171973 1994

Variations for Cerebrum Cancer

Expression for Cerebrum Cancer

Search GEO for disease gene expression data for Cerebrum Cancer.

Pathways for Cerebrum Cancer

Pathways related to Cerebrum Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.63 SYP RBFOX3 NF2 MYCN GFAP ENO2
2 11.03 SYP OLIG2 GFAP

GO Terms for Cerebrum Cancer

Biological processes related to Cerebrum Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 8.96 TP53 MYCN
2 regulation of stem cell proliferation GO:0072091 8.62 YAP1 NF2

Sources for Cerebrum Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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