MCID: CRV030
MIFTS: 35

Cervical Adenitis

Categories: Immune diseases

Aliases & Classifications for Cervical Adenitis

MalaCards integrated aliases for Cervical Adenitis:

Name: Cervical Adenitis 12 15
Cervical Lymphadenitis 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4637
NCIt 50 C26937
SNOMED-CT 68 3502005
UMLS 73 C0149642

Summaries for Cervical Adenitis

MalaCards based summary : Cervical Adenitis, also known as cervical lymphadenitis, is related to aphthous stomatitis and pharyngitis. An important gene associated with Cervical Adenitis is CARD8 (Caspase Recruitment Domain Family Member 8), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and tonsil.

Related Diseases for Cervical Adenitis

Diseases related to Cervical Adenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 aphthous stomatitis 30.4 IL1B MEFV NLRP3
2 pharyngitis 29.9 CARD8 FCGR1A IL1B MEFV
3 periodic fever, aphthous stomatitis, pharyngitis and adenitis 11.4
4 cervicitis 10.8
5 stomatitis 10.6
6 systemic onset juvenile idiopathic arthritis 10.3 IL1B MEFV
7 vulvar vestibulitis syndrome 10.3 IL1B NLRP3
8 schnitzler syndrome 10.3 IL1B NLRP3
9 chronic recurrent multifocal osteomyelitis 10.2 IL1B NLRP3
10 specific bursitis often of occupational origin 10.2 FCGR1A MEFV
11 hydrarthrosis 10.2 IL1B MEFV
12 aseptic meningitis 10.2 IL1B NLRP3
13 olecranon bursitis 10.2 FCGR1A MEFV
14 adult-onset still's disease 10.2 IL1B MEFV
15 familial cold autoinflammatory syndrome 10.2 IL1B NLRP3
16 psoriatic juvenile idiopathic arthritis 10.1 MEFV NLRP3
17 palindromic rheumatism 10.1 IL1B MEFV
18 erysipeloid 10.1 MEFV NLRP3
19 pericarditis 10.1 IL1B MEFV
20 suppurative otitis media 10.1 HSF4 IL1B
21 silicosis 10.1 IL1B NLRP3
22 pneumoconiosis 10.1 IL1B NLRP3
23 primary bacterial infectious disease 10.0 IL1B MEFV
24 bone inflammation disease 10.0 IL1B NLRP3
25 hypersensitivity reaction disease 10.0 IL1B MEFV
26 peritonitis 9.9 IL1B MEFV
27 nasopharyngeal carcinoma 9.9
28 glomerulonephritis 9.9
29 tonsillitis 9.9
30 nasopharyngitis 9.9
31 mycobacterium malmoense 9.9
32 gout 9.8 IL1B NLRP3
33 human immunodeficiency virus type 1 9.8
34 kawasaki disease 9.8
35 acute cervicitis 9.8
36 brucellosis 9.8
37 cat-scratch disease 9.8
38 intermediate uveitis 9.8
39 uveitis 9.8
40 hyperparathyroidism 9.8
41 toxic shock syndrome 9.8
42 chronic cervicitis 9.8
43 proliferative glomerulonephritis 9.8
44 pneumonia 9.8
45 acquired immunodeficiency syndrome 9.8
46 placenta disease 9.8
47 fasciitis 9.8
48 necrotizing fasciitis 9.8
49 mycobacterium fortuitum 9.8
50 paresthesia 9.8

Graphical network of the top 20 diseases related to Cervical Adenitis:



Diseases related to Cervical Adenitis

Symptoms & Phenotypes for Cervical Adenitis

Drugs & Therapeutics for Cervical Adenitis

Drugs for Cervical Adenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 1
2 Immunoglobulins Phase 1
3 Antibodies, Monoclonal Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Probiotics and Corticosteroids for Treating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) Withdrawn NCT02535962 Phase 2
2 Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Unknown status NCT02775994 Phase 1 Canakinumab

Search NIH Clinical Center for Cervical Adenitis

Genetic Tests for Cervical Adenitis

Anatomical Context for Cervical Adenitis

MalaCards organs/tissues related to Cervical Adenitis:

41
Thyroid, Lymph Node, Tonsil, Neutrophil, Monocytes, Myeloid

Publications for Cervical Adenitis

Articles related to Cervical Adenitis:

(show top 50) (show all 212)
# Title Authors Year
1
Tonsillar antimicrobial peptide (AMP) expression profiles of periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) patients. ( 29859567 )
2018
2
An international delphi survey for the definition of the variables for the development of new classification criteria for periodic fever aphtous stomatitis pharingitis cervical adenitis (PFAPA). ( 29669569 )
2018
3
Conservative treatment for cutaneous fistula resulted from abscess formation in patients with tuberculous cervical lymphadenitis. ( 29402607 )
2018
4
Pregnancy complicated with PFAPA (periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis) syndrome: a case report. ( 29866074 )
2018
5
The role of tonsillectomy in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome; a literature review. ( 29483843 )
2018
6
Minimally invasive approach to suppurated cervical lymphadenitis in children: Our experience on 60 patients. ( 29687954 )
2018
7
Image Gallery: Cervical lymphadenitis as an unusual presentation of disseminated coccidioidomycosis. ( 29897112 )
2018
8
Nine patients with chronic granulomatous disease having selective neck dissection for severe cervical lymphadenitis. ( 28727298 )
2017
9
INTERMEDIATE UVEITIS ASSOCIATED WITH PERIODIC FEVER, APHTHOUS STOMATITIS, PHARYNGITIS, AND CERVICAL ADENITIS SYNDROME. ( 28570435 )
2017
10
Mandibular Osteomyelitis and Cervical Lymphadenitis Due to Mycobacterium abscessus: Surgical Management of a Pediatric Cohort With a Shared Epidemiologic Exposure. ( 28938329 )
2017
11
Periodic Fever with Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome Is Associated with a CARD8 Variant Unable To Bind the NLRP3 Inflammasome. ( 28137891 )
2017
12
Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (pfapa) syndrome in children. ( 28343210 )
2017
13
Diagnostic Criteria for Adult-Onset Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome. ( 28970828 )
2017
14
A 38-year-old woman with necrotising cervical lymphadenitis due to Histoplasma capsulatum. ( 28822097 )
2017
15
Unraveling the pathogenesis of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis through genetic, immunologic, and microbiologic discoveries: an update. ( 28557837 )
2017
16
A case of cervical radiculopathy due to tuberculosis cervical lymphadenitis. ( 29620071 )
2017
17
Unique histologic features of tonsils from patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 28748511 )
2017
18
Physicians' perspectives on the diagnosis and management of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 28271158 )
2017
19
Evolving Frontiers in the Treatment of Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) Syndrome. ( 28786261 )
2017
20
Is colchicine more effective to prevent periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis episodes in Mediterranean fever gene variants? ( 28207965 )
2017
21
Tuberculosis Cervical Adenitis: Management Dilemmas. ( 27273690 )
2016
22
Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) syndrome: analysis of patients from two geographic areas. ( 27059542 )
2016
23
Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome: a Review of the Pathogenesis. ( 26984802 )
2016
24
Suggested Protocol for Managing Acute Suppurative Cervical Lymphadenitis in Children to Reduce Unnecessary Surgical Interventions. ( 27553593 )
2016
25
Coccidioides immitis Cervical Lymphadenitis Complicated by Esophageal Fistula. ( 27313922 )
2016
26
Is colchicine an effective treatment in periodic fever, aphtous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome? ( 27068612 )
2016
27
Review of autoinflammatory diseases, with a special focus on periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome. ( 27426283 )
2016
28
Similar presentation of cervical lymphadenitis of different etiology in two siblings. ( 27422429 )
2016
29
Analysis of the genetic basis of periodic fever with aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 25988833 )
2015
30
Reduced number of CD8+ cells in tonsillar germinal centers in children with the Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome. ( 25882211 )
2015
31
The Pathogenesis of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome: A Review of Current Research. ( 26457006 )
2015
32
Late onset of cryptococcal cervical lymphadenitis following immune reconstitution inflammatory syndrome in a patient with AIDS. ( 25564633 )
2015
33
Mycobacterium bovis cervical lymphadenitis: A representative case and review. ( 26388186 )
2015
34
Colchicine as a therapeutic option in periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome. ( 26315860 )
2015
35
Actinomyces neuii Isolated From a 20-Month-Old Girl With Cervical Lymphadenitis. ( 26407440 )
2015
36
Managing cervical lymphadenitis-a total pain in the neck! ( 25290125 )
2014
37
Erratum for healthy baby: managing cervical lymphadenitis-a totalpain in the neck! ( 25692520 )
2014
38
Vitamin D levels and effects of vitamin D replacement in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 24746456 )
2014
39
Sinus Histiocytosis and Massive Lymphadenopathy (Rosai-Dorfman Disease) Mimicking Cervical Lymphadenitis. ( 24412136 )
2014
40
Markedly elevated CD64 expressions on neutrophils and monocytes are useful for diagnosis of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome during flares. ( 24623459 )
2014
41
International periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome cohort: description of distinct phenotypes in 301 patients. ( 24505122 )
2014
42
Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Syndrome in Iranian Children First Report of Iranian Periodic Fever and Autoinflammatory Registry (IPFAIR). ( 25793068 )
2014
43
Pulmonary Mycobacterium fortuitum infection with cervical lymphadenitis in a patient carrying autoantibodies to interferon-I^. ( 24930658 )
2014
44
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). ( 25209127 )
2014
45
Tuberculosis or tularemia? A molecular study in cervical lymphadenitis. ( 24239221 )
2014
46
Acute cervical lymphadenitis and infections of the retropharyngeal and parapharyngeal spaces in children. ( 25206314 )
2014
47
Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome is linked to dysregulated monocyte IL-1I^ production. ( 23006543 )
2013
48
Lymph-node-first presentation of Kawasaki disease compared with bacterial cervical adenitis and typical Kawasaki disease. ( 23305955 )
2013
49
A case of adult periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome associated with endocapillary proliferative glomerulonephritis. ( 20225048 )
2013
50
Cervical Lymphadenitis Caused by Group D Non-typhoidal Salmonella Associated with Concomitant Lymphoma. ( 24265973 )
2013

Variations for Cervical Adenitis

Expression for Cervical Adenitis

Search GEO for disease gene expression data for Cervical Adenitis.

Pathways for Cervical Adenitis

GO Terms for Cervical Adenitis

Cellular components related to Cervical Adenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 autophagosome GO:0005776 8.96 IL1B MEFV
2 NLRP3 inflammasome complex GO:0072559 8.62 CARD8 NLRP3

Biological processes related to Cervical Adenitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.67 FCGR1A MEFV NLRP3
2 inflammatory response GO:0006954 9.61 IL1B MEFV NLRP3
3 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.48 CARD8 NLRP3
4 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.46 CARD8 NLRP3
5 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.4 CARD8 NLRP3
6 signaling GO:0023052 9.37 CARD8 NLRP3
7 negative regulation of inflammatory response GO:0050728 9.33 MEFV MVK NLRP3
8 positive regulation of interleukin-1 beta secretion GO:0050718 9.32 CARD8 NLRP3
9 negative regulation of interleukin-1 beta secretion GO:0050713 9.26 CARD8 NLRP3
10 interleukin-1 beta production GO:0032611 8.96 IL1B NLRP3
11 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 8.8 CARD8 IL1B NLRP3

Molecular functions related to Cervical Adenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.92 CARD8 MEFV MVK NLRP3

Sources for Cervical Adenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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