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MCID: CRV030
MIFTS: 38

Cervical Adenitis

Categories: Immune diseases
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Genes Tissues Related diseases Publications
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Aliases & Classifications for Cervical Adenitis

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MalaCards integrated aliases for Cervical Adenitis:

Name: Cervical Adenitis 11 14
Cervical Lymphadenitis 11 71

Classifications:

MalaCards categories:
Anatomical: Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 11 DOID:4637
NCIt 49 C26937
SNOMED-CT 68 3502005
UMLS 71 C0149642
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Summaries for Cervical Adenitis

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MalaCards based summary: Cervical Adenitis, also known as cervical lymphadenitis, is related to lymphadenitis and autoinflammatory syndrome. An important gene associated with Cervical Adenitis is MVK (Mevalonate Kinase), and among its related pathways/superpathways are Innate Immune System and 4-1BB Pathway. Affiliated tissues include lymph node, thyroid and salivary gland, and related phenotypes are hematopoietic system and integument
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Related Diseases for Cervical Adenitis

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Diseases related to Cervical Adenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 660)
# Related Disease Score Top Affiliating Genes
1 lymphadenitis 30.7 TNF ITPKC IL1B IFNG CRP
2 autoinflammatory syndrome 30.7 NLRP3 MVK MEFV
3 stomatitis 30.5 TNF NLRP3 MEFV IL1B IFNG CD4
4 familial mediterranean fever 30.4 TNFRSF1A TNF NLRP3 MVK MEFV IL1B
5 cat-scratch disease 30.4 HSPD1 CRP CD4
6 hyper-igd syndrome 30.4 MVK CRP
7 tonsillitis 30.3 TNF IL1B IFNG
8 lymph node tuberculosis 30.1 TNF IFNG CRP CD4
9 aphthous stomatitis 30.1 TNF NLRP3 MVK MEFV IL1B IFNG
10 toxoplasmosis 29.9 TNF IL1B IFNG
11 brucellosis 29.9 TNF NLRP3 MEFV IFNG CRP
12 pfeiffer syndrome 29.8 TNF CRP CD4
13 muckle-wells syndrome 29.8 TNFRSF1A NLRP3 MVK MEFV IL1B
14 pharyngitis 29.8 TNF SPAG7 NLRP3 MVK MEFV IL1B
15 syphilis 29.7 TNF CRP CD4
16 secondary syphilis 29.7 TNF CRP CD4
17 haemophilus influenzae 29.7 TNF IL1B
18 tularemia 29.7 TNF PDE6B IL1B HSPD1 CD4
19 polyarteritis nodosa 29.7 TNF MEFV CRP
20 cellulitis 29.7 TNF IL1B CRP CD4
21 actinomycosis 29.7 TNF HSPD1 CRP CD4
22 necrotizing fasciitis 29.7 TNF IL1B CRP
23 neutrophilic dermatosis, acute febrile 29.7 TNF MEFV IL1B CRP
24 apnea, obstructive sleep 29.7 TNF IL1B CRP
25 intermediate uveitis 29.7 TNF IFNG CD4
26 sleep apnea 29.6 TNF IL1B CRP
27 thyroiditis 29.6 TNF IL1B IFNG CRP
28 suppurative lymphadenitis 29.6 PDE6B IFNG CYBB CRP CD4
29 bowel dysfunction 29.6 TNF IL1B CRP
30 histoplasmosis 29.6 TNF IFNG CD4
31 cryptococcosis 29.6 TNF IFNG CD4
32 typhoid fever 29.5 TNFRSF1A TNF IL1B IFNG CRP
33 listeriosis 29.5 TNF IL1B CD4
34 henoch-schoenlein purpura 29.5 TNF MEFV CRP CD4
35 pulmonary tuberculosis 29.5 TNF IL1B IFNG CRP
36 urinary tract infection 29.5 TNF IL1B CRP CD4
37 toxic shock syndrome 29.4 TNF IL1B IFNG CRP
38 pneumocystosis 29.4 TNF IFNG CRP CD4
39 endophthalmitis 29.4 TNF IL1B CRP CD4
40 legionellosis 29.4 TNF IL1B CRP CD4
41 legionnaire disease 29.4 TNF IL1B CRP CD4
42 chlamydia 29.4 TNF IL1B IFNG HSPD1 CRP
43 blau syndrome 29.4 TNF NLRP3 MVK MEFV IL1B
44 purpura 29.4 TNF IL1B IFNG CRP
45 erythema nodosum 29.4 TNF IL1B IFNG CRP
46 neutropenia 29.4 TNFRSF1A TNF IL1B IFNG CRP
47 salmonellosis 29.4 TNF NLRP3 IL1B IFNG CD4
48 vasculitis 29.4 TNF MEFV IL1B HSPD1 CRP
49 gastroenteritis 29.4 TNF IL1B IFNG CRP
50 macs syndrome 29.3 TNF IFNG HSPD1 CD4

Graphical network of the top 20 diseases related to Cervical Adenitis:



Diseases related to Cervical Adenitis
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Symptoms & Phenotypes for Cervical Adenitis

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MGI Mouse Phenotypes related to Cervical Adenitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CD4 CYBB HSPD1 IFNG IL1B ITPKC
2 integument MP:0010771 9.28 CD4 HSPD1 IFNG IL1B MEFV NLRP3
Sources

Drugs & Therapeutics for Cervical Adenitis

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Probiotic Addition to Corticosteroid Treatment for PFAPA Withdrawn NCT02535962 Phase 2
2 Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Unknown status NCT02775994 Phase 1 Canakinumab

Search NIH Clinical Center for Cervical Adenitis

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Genetic Tests for Cervical Adenitis

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Anatomical Context for Cervical Adenitis

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Organs/tissues related to Cervical Adenitis:

MalaCards : Lymph Node, Thyroid, Salivary Gland, Myeloid, Skin, Monocytes, Liver
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Publications for Cervical Adenitis

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Articles related to Cervical Adenitis:

(show top 50) (show all 1064)
# Title Authors PMID Year
1
Two Distinct Cases of Adult-onset Kawasaki Disease. 62
35466164 2022
2
Kikuchi lymphadenitis: A differential diagnosis of tuberculous cervical lymphadenitis. 62
36380612 2022
3
Does having MEFV gene sequence variants affect the clinical course and colchicine response in children with PFAPA syndrome? 62
36376520 2022
4
The diagnostic and prognostic value of plasma circulating circNUP98 for nasopharyngeal carcinoma. 62
36330641 2022
5
A Seven-Year-Old With Cervical Lymphadenitis and Multiple Animal Exposures. 62
36345070 2022
6
Synchronous disease onset and flares in siblings with PFAPA. 62
36199113 2022
7
NLRP3 gene variants and serum NLRP3 levels in periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome. 62
36087224 2022
8
Epidemiology and clinical features of PFAPA: a retrospective cohort study of 336 patients in western Sweden. 62
36109811 2022
9
Age-Related Clinical Manifestation of Suppurative Cervical Lymphadenitis in Children. 62
35524369 2022
10
[Professor SHAO Jing-ming's clinical experience of fire needling for surgical diseases]. 62
36075601 2022
11
Cervical lymphadenitis antibiotic regimen in pediatrics, stewarded? 62
35798658 2022
12
The role of inflammatory mediators in the pathogenesis of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome. 62
35320440 2022
13
Colchicine versus cimetidine: the better choice for Periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome prophylaxis, and the role of MEFV gene mutations. 62
36045426 2022
14
Disease and economic burden of infections in hospitalised children in New South Wales, Australia. 62
35667892 2022
15
Increased Frequency of Febrile Seizures in Two Periodic Fever Syndromes: Familial Mediterranean Fever and PFAPA Syndrome. 62
35822475 2022
16
A novel case of lupus nephritis and mixed connective tissue disorder in a COVID-19 patient. 62
35495962 2022
17
An Adult Female Presenting With "Scrofula-Tubercular Lymphadenitis" a Rare Encounter: A Case Report. 62
35785004 2022
18
Extensive Relapsing Cervical Lymphadenitis Due to Streptococcus Pseudoporcinus in an Infant. 62
35333825 2022
19
Mevalonate kinase deficiency/Hyperimmunoglobulin D syndrome (MVK/HIDS) in a Differential Diagnosis of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome and Familial Mediterranean Fever (FMF): A Case Report. 62
35781244 2022
20
Efficacy of Canakinumab in a Patient With Adult-Onset Glucocorticoid-Resistant Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Syndrome. 62
35639987 2022
21
Lymph-node-first presentation of Kawasaki disease in a 12-year-old girl with cervical lymphadenitis caused by Mycoplasma pneumoniae: A case report. 62
35611136 2022
22
First documented co-infection case of cat-scratch disease and melioidosis in Malaysia: A cause of undifferentiated prolonged febrile illness. 62
35338639 2022
23
Profile and histopathology features of top three cases of Extra Pulmonary Tuberculosis (EPTB) in West Nusa Tenggara: A retrospective cross-sectional study. 62
35242312 2022
24
The fine-needle aspiration cytology and clinical findings of Kikuchi-Fujimoto disease in pediatric patients: a retrospective clinical study. 62
35235442 2022
25
Kikuchi-Fujimoto disease in a tertiary care teaching hospital in Coastal South India: A 8-year retrospective study. 62
35811790 2022
26
Development and implementation of the AIDA International Registry for patients with Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis syndrome. 62
35935379 2022
27
Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome (PFAPA) or recurrent urinary tract infections: a case report. 62
35081911 2022
28
The rs13075270 and rs13092160 polymorphisms of CCR1 and CCR3 genes on oral aphthous-like lesions in PFAPA syndrome. 62
35809272 2022
29
PFAPA Syndrome: Clinical, Laboratory and Therapeutic Features in a Single-Centre Cohort. 62
36061962 2022
30
Challenges in the diagnosis of periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome in developing countries-A decade of experience from North India. 62
36203600 2022
31
Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome in children: a brief literature review. 62
35703722 2022
32
Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome: Clinical characteristics and treatment outcomes - a single center study in Japan. 62
36134651 2022
33
Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis Syndrome: A Single-Center Experience. 62
35110078 2022
34
Kawasaki Shock Syndrome with Initial Presentation as Neck lymphadenitis: A Case Report. 62
35053681 2022
35
Lingual Tonsillectomy: Successful Treatment of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome. 62
33492030 2021
36
[What is confirmed in the treatment of autoinflammatory fever diseases?] 62
34878558 2021
37
PFAPA (periodic fever, aphthous stomatitis, pharyngitis, and adenitis) syndrome: an overview of genetic background. 62
34014414 2021
38
Usefulness of brain natriuretic peptide to distinguish Kawasaki disease from cervical lymphadenitis. 62
34739174 2021
39
A Rare Case Presentation of Spina Ventosa Associated with Lichen Scrofulosorum and A Tuberculoma. 62
35415110 2021
40
Rare manifestation of common disease: An adolescent girl with transient ischemic attack (TIA) like presentation in multiple tuberculoma. 62
35136808 2021
41
A Rare Case of Kikuchi-Fujimoto Disease in a Young Female Patient. 62
34802030 2021
42
Kikuchi Cervical Lymphadenitis in Children: Ultrasound Differentiation From Common Infectious Lymphadenitis. 62
33263358 2021
43
Role of ultrasound in the diagnosis of cervical tuberculous lymphadenitis in children. 62
34472036 2021
44
Colchicine - From rheumatology to the new kid on the block: Coronary syndromes and COVID-19. 62
34642922 2021
45
Lymphadenopathy at the crossroad between immunodeficiency and autoinflammation: An intriguing challenge. 62
34008169 2021
46
Interferon-Gamma Release Assays Differentiate between Mycobacterium avium Complex and Tuberculous Lymphadenitis in Children. 62
33984332 2021
47
Nontuberculous mycobacterial infections in children in the Czech Republic in the period 2003-2018. 62
32675804 2021
48
Evaluating Lymph Node Stiffness to Differentiate Bacterial Cervical Lymphadenitis and Lymph Node-First Presentation of Kawasaki Disease by Shear Wave Elastography. 62
33006783 2021
49
Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome: Relapse and Tonsillar Regrowth After Childhood Tonsillectomy. 62
33630321 2021
50
Case Report: A Case of Tuberculosis with Psoriasiform Lichen Scrofulosorum Exhibiting Koebner's Phenomenon followed by Scrofuloderma. 62
34314372 2021
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Variations for Cervical Adenitis

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Expression for Cervical Adenitis

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Search GEO for disease gene expression data for Cervical Adenitis.
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Pathways for Cervical Adenitis

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Pathways related to Cervical Adenitis according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.86 TNFRSF1A TNF NLRP3 MEFV IL1B IFNG
2
4-1BB Pathway 64
Show member pathways
 12.53 TNFRSF1A TNF IL1B IFNG CD4
3
Immune response IL-23 signaling pathway 22
Show member pathways
 12.47 TNF IL1B IFNG CD4
4
NF-kappaB Signaling 3
12.45 IFNG IL1B TNF TNFRSF1A
5
Neuroinflammation and glutamatergic signaling 74
11.96 TNFRSF1A TNF IL1B IFNG
6
Hematopoietic Stem Cells and Lineage-specific Markers 65
11.9 TNF IFNG CD4
7
Spinal cord injury 74
11.9 TNF IL1B IFNG
8
IL12-mediated signaling events 61
Show member pathways
 11.87 IL1B IFNG CD4
9
Inflammasomes 66
Show member pathways
 11.83 NLRP3 MEFV IL1B
10
Allograft rejection 74
11.77 TNF IL1B IFNG
11
Th17 Differentiation 65
Show member pathways
 11.75 IL1B IFNG CD4
12
IL27-mediated signaling events 61
Show member pathways
 11.71 TNF IL1B IFNG CD4
13
Extrafollicular B cell activation by SARS-CoV-2 74
11.64 TNF IFNG CRP
14
Th17 cell differentiation pathway 74
11.62 IL1B IFNG CD4
15
Innate Lymphoid Cells Differentiation 65
11.57 TNF IL1B IFNG CD4
16
NF-kB (NFkB) Pathway 67
11.51 TNFRSF1A TNF CD4
17
Dendritic Cells Developmental Lineage Pathway 65
11.49 TNF IL1B IFNG CD4
18
Non-genomic actions of 1,25 dihydroxyvitamin D3 74
11.47 TNFRSF1A TNF IFNG
19
MSP-RON Signaling 64
11.43 TNF IL1B IFNG
20
Interleukin-10 signaling 66
11.42 IL1B TNF TNFRSF1A
21
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.39 TNF IL1B IFNG
22
THC Differentiation Pathway 64
11.38 TNFRSF1A TNF IFNG CD4
23
Photodynamic therapy-induced NF-kB survival signaling 74
Show member pathways
 11.36 TNFRSF1A TNF IL1B IFNG
24
Type II interferon signaling 74
11.29 IL1B IFNG CYBB
25
IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types 65
Show member pathways
 11.26 TNFRSF1A TNF IFNG
26
Development and heterogeneity of the ILC family 74
11.18 TNF IL1B IFNG
27
Prostaglandin signaling 74
11.08 TNF NLRP3 IL1B
28
Nucleotide-binding oligomerization domain (NOD) pathway 74
11.07 NLRP3 MEFV IL1B CARD8
29
IL1 and megakaryocytes in obesity 74
10.99 IFNG IL1B NLRP3
30
Activation of NF-KappaB by PKR 64
Show member pathways
 10.92 TNFRSF1A TNF NLRP3 IL1B IFNG
31
LDL Oxidation in Atherogenesis 64
10.87 TNF IL1B
32
Selective expression of chemokine receptors during T-cell polarization 74
10.83 IFNG CD4
33
Cytokines and inflammatory response 74
10.72 TNF IL1B IFNG CD4
34
Nanoparticle triggered regulated necrosis 74
10.71 TNFRSF1A TNF
35
Activation of NLRP3 inflammasome by SARS-CoV-2 74
10.44 NLRP3 IL1B
Sources

GO Terms for Cervical Adenitis

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Cellular components related to Cervical Adenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammasome complex GO:0061702 9.02 NLRP3 MEFV CARD8

Biological processes related to Cervical Adenitis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 10.32 NLRP3 MEFV DEFB112 CYBB CRP CARD8
2 positive regulation of interleukin-6 production GO:0032755 10.1 HSPD1 IFNG IL1B TNF
3 defense response to Gram-positive bacterium GO:0050830 10.09 CRP IL1B NLRP3 TNF
4 positive regulation of phagocytosis GO:0050766 10.08 TNF IL1B IFNG
5 regulation of insulin secretion GO:0050796 10.08 TNF IL1B IFNG
6 negative regulation of inflammatory response GO:0050728 10.07 TNFRSF1A NLRP3 MVK MEFV
7 positive regulation of nitric oxide biosynthetic process GO:0045429 10.05 TNF IL1B IFNG
8 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 10.01 CARD8 NLRP3 TNF
9 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 10.01 TNF IL1B CARD8
10 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 10 TNF NLRP3 HSPD1 CARD8
11 positive regulation of chemokine production GO:0032722 9.99 TNF IL1B IFNG
12 negative regulation of interleukin-1 beta production GO:0032691 9.96 NLRP3 MEFV CARD8
13 positive regulation of interleukin-1 beta production GO:0032731 9.96 CARD8 IFNG MEFV NLRP3 TNF
14 negative regulation of NLRP3 inflammasome complex assembly GO:1900226 9.93 MEFV CARD8
15 vascular endothelial growth factor production GO:0010573 9.92 TNF IL1B
16 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.91 TNF IL1B IFNG
17 positive regulation of fever generation GO:0031622 9.88 IL1B TNF
18 astrocyte activation GO:0048143 9.88 IFNG IL1B TNF
19 sequestering of triglyceride GO:0030730 9.87 TNF IL1B
20 inflammatory response GO:0006954 9.86 TNFRSF1A TNF NLRP3 MEFV IL1B CYBB
21 regulation of establishment of endothelial barrier GO:1903140 9.85 TNFRSF1A TNF IL1B
22 positive regulation of nitrogen compound metabolic process GO:0051173 9.81 TNF IFNG
23 defense response GO:0006952 9.8 TNFRSF1A TNF NLRP3 DEFB112 CYBB
24 positive regulation of vitamin D biosynthetic process GO:0060557 9.78 TNF IFNG
25 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.63 TNF IL1B IFNG
26 positive regulation of inflammatory response GO:0050729 9.32 TNFRSF1A TNF NLRP3 MEFV IL1B IFNG
Sources

Sources for Cervical Adenitis

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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