MCID: CRV030
MIFTS: 36

Cervical Adenitis

Categories: Immune diseases

Aliases & Classifications for Cervical Adenitis

MalaCards integrated aliases for Cervical Adenitis:

Name: Cervical Adenitis 12 15
Cervical Lymphadenitis 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4637
NCIt 50 C26937
SNOMED-CT 68 3502005
UMLS 73 C0149642

Summaries for Cervical Adenitis

MalaCards based summary : Cervical Adenitis, also known as cervical lymphadenitis, is related to stomatitis and aphthous stomatitis. An important gene associated with Cervical Adenitis is CARD8 (Caspase Recruitment Domain Family Member 8), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The drugs Immunologic Factors and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include testes, thyroid and lymph node.

Related Diseases for Cervical Adenitis

Diseases related to Cervical Adenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 stomatitis 31.2 IL1B MEFV
2 aphthous stomatitis 30.9 IL1B MEFV NLRP3
3 pharyngitis 30.8 CARD8 FCGR1A IL1B MEFV
4 periodic fever, aphthous stomatitis, pharyngitis and adenitis 11.5
5 lymphadenitis 11.0
6 tularemia 10.2
7 familial cold autoinflammatory syndrome 10.1 IL1B NLRP3
8 vulvar vestibulitis syndrome 10.1 IL1B NLRP3
9 schnitzler syndrome 10.1 IL1B NLRP3
10 chronic recurrent multifocal osteomyelitis 10.1 IL1B NLRP3
11 specific bursitis often of occupational origin 10.1 FCGR1A MEFV
12 hydrarthrosis 10.1 IL1B MEFV
13 aseptic meningitis 10.1 IL1B NLRP3
14 olecranon bursitis 10.1 FCGR1A MEFV
15 meningitis 10.0 IL1B NLRP3
16 adult-onset still's disease 10.0 IL1B MEFV
17 psoriatic juvenile idiopathic arthritis 10.0 MEFV NLRP3
18 palindromic rheumatism 10.0 IL1B MEFV
19 erysipeloid 10.0 MEFV NLRP3
20 pericarditis 10.0 IL1B MEFV
21 nasopharyngeal carcinoma 10.0
22 glomerulonephritis 10.0
23 mycobacterium malmoense 10.0
24 silicosis 10.0 IL1B NLRP3
25 bacterial infectious disease 10.0 FCGR1A IL1B
26 pneumoconiosis 10.0 IL1B NLRP3
27 primary bacterial infectious disease 10.0 IL1B MEFV
28 relapsing fever 10.0 MEFV MVK
29 bone inflammation disease 10.0 IL1B NLRP3
30 mevalonic aciduria 10.0 MVK NLRP3
31 peritonitis 10.0 IL1B MEFV
32 suppurative otitis media 10.0 HSF4 IL1B
33 thyroid cancer, nonmedullary, 1 9.9
34 parotitis 9.9
35 thyroiditis 9.9
36 mycobacterium abscessus 9.9
37 immune system disease 9.9 IL1B MEFV
38 gout 9.9 IL1B NLRP3
39 familial cold autoinflammatory syndrome 1 9.9 IL1B MEFV NLRP3
40 muckle-wells syndrome 9.9 IL1B MEFV NLRP3
41 wells syndrome 9.9 IL1B MEFV NLRP3
42 human immunodeficiency virus type 1 9.9
43 kawasaki disease 9.9
44 cat-scratch disease 9.9
45 intermediate uveitis 9.9
46 uveitis 9.9
47 hyperparathyroidism 9.9
48 toxic shock syndrome 9.9
49 proliferative glomerulonephritis 9.9
50 acquired immunodeficiency syndrome 9.9

Graphical network of the top 20 diseases related to Cervical Adenitis:



Diseases related to Cervical Adenitis

Symptoms & Phenotypes for Cervical Adenitis

Drugs & Therapeutics for Cervical Adenitis

Drugs for Cervical Adenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 1
2 Immunoglobulins Phase 1
3 Antibodies, Monoclonal Phase 1
4 Antibodies Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Probiotics and Corticosteroids for Treating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) Withdrawn NCT02535962 Phase 2
2 Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Recruiting NCT02775994 Phase 1 Canakinumab

Search NIH Clinical Center for Cervical Adenitis

Genetic Tests for Cervical Adenitis

Anatomical Context for Cervical Adenitis

MalaCards organs/tissues related to Cervical Adenitis:

41
Testes, Thyroid, Lymph Node, Tonsil, Monocytes, Myeloid, Bone

Publications for Cervical Adenitis

Articles related to Cervical Adenitis:

(show top 50) (show all 349)
# Title Authors Year
1
Tonsillar antimicrobial peptide (AMP) expression profiles of periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) patients. ( 29859567 )
2018
2
An international delphi survey for the definition of the variables for the development of new classification criteria for periodic fever aphtous stomatitis pharingitis cervical adenitis (PFAPA). ( 29669569 )
2018
3
Conservative treatment for cutaneous fistula resulted from abscess formation in patients with tuberculous cervical lymphadenitis. ( 29402607 )
2018
4
Pregnancy complicated with PFAPA (periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis) syndrome: a case report. ( 29866074 )
2018
5
The role of tonsillectomy in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome; a literature review. ( 29483843 )
2018
6
Minimally invasive approach to suppurated cervical lymphadenitis in children: Our experience on 60 patients. ( 29687954 )
2018
7
Image Gallery: Cervical lymphadenitis as an unusual presentation of disseminated coccidioidomycosis. ( 29897112 )
2018
8
Treatment options for periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome in children and adults: a narrative review. ( 30488366 )
2018
9
Brain abscess and cervical lymphadenitis due to Paraclostridium bifermentans: A report of two cases. ( 29526826 )
2018
10
Efficacy of Fine-Needle Aspiration Cytology in the Diagnosis of Tuberculous Cervical Lymphadenitis. ( 29587250 )
2018
11
Surgical treatment for chronic cervical lymphadenitis in children. Experience from a tertiary care paediatric centre on non-tuberculous mycobacterial infections. ( 29605343 )
2018
12
Chronic Neutropenia in Children with Abscess Forming Cervical Lymphadenitis Caused by Staphylococcus aureus. ( 29613972 )
2018
13
Persistent cervical lymphadenitis in a patient with prior thyroid cancer attributed to Kikuchi-Fujimoto disease. ( 30344150 )
2018
14
Nine patients with chronic granulomatous disease having selective neck dissection for severe cervical lymphadenitis. ( 28727298 )
2017
15
INTERMEDIATE UVEITIS ASSOCIATED WITH PERIODIC FEVER, APHTHOUS STOMATITIS, PHARYNGITIS, AND CERVICAL ADENITIS SYNDROME. ( 28570435 )
2017
16
Mandibular Osteomyelitis and Cervical Lymphadenitis Due to Mycobacterium abscessus: Surgical Management of a Pediatric Cohort With a Shared Epidemiologic Exposure. ( 28938329 )
2017
17
Periodic Fever with Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome Is Associated with a CARD8 Variant Unable To Bind the NLRP3 Inflammasome. ( 28137891 )
2017
18
Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (pfapa) syndrome in children. ( 28343210 )
2017
19
Diagnostic Criteria for Adult-Onset Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome. ( 28970828 )
2017
20
A 38-year-old woman with necrotising cervical lymphadenitis due to Histoplasma capsulatum. ( 28822097 )
2017
21
Unraveling the pathogenesis of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis through genetic, immunologic, and microbiologic discoveries: an update. ( 28557837 )
2017
22
A case of cervical radiculopathy due to tuberculosis cervical lymphadenitis. ( 29620071 )
2017
23
Unique histologic features of tonsils from patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 28748511 )
2017
24
Physicians' perspectives on the diagnosis and management of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 28271158 )
2017
25
Evolving Frontiers in the Treatment of Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) Syndrome. ( 28786261 )
2017
26
Is colchicine more effective to prevent periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis episodes in Mediterranean fever gene variants? ( 28207965 )
2017
27
Tuberculosis Cervical Adenitis: Management Dilemmas. ( 27273690 )
2016
28
Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) syndrome: analysis of patients from two geographic areas. ( 27059542 )
2016
29
Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome: a Review of the Pathogenesis. ( 26984802 )
2016
30
Suggested Protocol for Managing Acute Suppurative Cervical Lymphadenitis in Children to Reduce Unnecessary Surgical Interventions. ( 27553593 )
2016
31
Coccidioides immitis Cervical Lymphadenitis Complicated by Esophageal Fistula. ( 27313922 )
2016
32
Is colchicine an effective treatment in periodic fever, aphtous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome? ( 27068612 )
2016
33
Review of autoinflammatory diseases, with a special focus on periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome. ( 27426283 )
2016
34
Similar presentation of cervical lymphadenitis of different etiology in two siblings. ( 27422429 )
2016
35
Analysis of the genetic basis of periodic fever with aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 25988833 )
2015
36
Reduced number of CD8+ cells in tonsillar germinal centers in children with the Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome. ( 25882211 )
2015
37
The Pathogenesis of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome: A Review of Current Research. ( 26457006 )
2015
38
Late onset of cryptococcal cervical lymphadenitis following immune reconstitution inflammatory syndrome in a patient with AIDS. ( 25564633 )
2015
39
Mycobacterium bovis cervical lymphadenitis: A representative case and review. ( 26388186 )
2015
40
Colchicine as a therapeutic option in periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome. ( 26315860 )
2015
41
Extensive cervical lymphadenitis mimicking bacterial adenitis as the first presentation of Kawasaki disease. ( 26132362 )
2015
42
A case of child nasopharyngeal carcinoma admitted with cervical lymphadenitis responsive to antibiotic therapy. ( 25458639 )
2015
43
Suppurative cervical lymphadenitis in infancy: microbiology and sociology. ( 25972051 )
2015
44
Tuberculous cervical lymphadenitis in a gouty patient treated with anakinra. ( 26010193 )
2015
45
Actinomyces neuii Isolated From a 20-Month-Old Girl With Cervical Lymphadenitis. ( 26407440 )
2015
46
Clinical and pathologic diagnosis and different diagnosis of syphilis cervical lymphadenitis. ( 26722588 )
2015
47
Managing cervical lymphadenitis-a total pain in the neck! ( 25290125 )
2014
48
Erratum for healthy baby: managing cervical lymphadenitis-a totalpain in the neck! ( 25692520 )
2014
49
Vitamin D levels and effects of vitamin D replacement in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. ( 24746456 )
2014
50
Sinus Histiocytosis and Massive Lymphadenopathy (Rosai-Dorfman Disease) Mimicking Cervical Lymphadenitis. ( 24412136 )
2014

Variations for Cervical Adenitis

Expression for Cervical Adenitis

Search GEO for disease gene expression data for Cervical Adenitis.

Pathways for Cervical Adenitis

GO Terms for Cervical Adenitis

Cellular components related to Cervical Adenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 autophagosome GO:0005776 9.16 IL1B MEFV
2 inflammasome complex GO:0061702 8.96 CARD8 NLRP3
3 NLRP3 inflammasome complex GO:0072559 8.62 CARD8 NLRP3

Biological processes related to Cervical Adenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.63 FCGR1A MEFV NLRP3
2 inflammatory response GO:0006954 9.54 IL1B MEFV NLRP3
3 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.43 CARD8 NLRP3
4 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.4 CARD8 NLRP3
5 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.32 CARD8 NLRP3
6 positive regulation of interleukin-1 beta secretion GO:0050718 9.26 CARD8 NLRP3
7 negative regulation of interleukin-1 beta secretion GO:0050713 9.16 CARD8 NLRP3
8 negative regulation of inflammatory response GO:0050728 9.13 MEFV MVK NLRP3
9 interleukin-1 beta production GO:0032611 8.62 IL1B NLRP3

Sources for Cervical Adenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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