MCID: CRV030
MIFTS: 38

Cervical Adenitis

Categories: Immune diseases

Aliases & Classifications for Cervical Adenitis

MalaCards integrated aliases for Cervical Adenitis:

Name: Cervical Adenitis 12 15
Cervical Lymphadenitis 12 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4637
NCIt 49 C26937
SNOMED-CT 67 3502005
UMLS 71 C0149642

Summaries for Cervical Adenitis

MalaCards based summary : Cervical Adenitis, also known as cervical lymphadenitis, is related to aphthous stomatitis and stomatitis. An important gene associated with Cervical Adenitis is IL1B (Interleukin 1 Beta), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Antibodies, Monoclonal and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and tonsil, and related phenotypes are cellular and hematopoietic system

Related Diseases for Cervical Adenitis

Diseases related to Cervical Adenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 316)
# Related Disease Score Top Affiliating Genes
1 aphthous stomatitis 30.9 NLRP3 MEFV IL1RN IL1B CARD8
2 stomatitis 30.6 NLRP3 MEFV IL1RN IL1B CD40LG
3 autoinflammatory syndrome 30.6 NLRP3 NLRP12
4 parotitis 30.2 CRP CD40LG
5 pyuria 30.0 CRP CD40LG
6 osteomyelitis 30.0 NLRP3 IL1RN IL1B
7 extrapulmonary tuberculosis 30.0 IL1RN IL1B CRP
8 cat-scratch disease 30.0 HSPD1 CRP CD40LG
9 otitis media 30.0 IL1B CRP CD40LG
10 henoch-schoenlein purpura 29.9 MEFV CRP CD40LG
11 purpura 29.9 MEFV CRP CD40LG
12 tularemia 29.8 PDE6B HSPD1 CD40LG
13 leprosy 3 29.8 IL1B HSPD1 CD40LG
14 chlamydia 29.7 IL1B HSPD1 CRP CD40LG
15 syphilis 29.7 NLRP12 CRP CD40LG
16 legionellosis 29.7 IL1B HSPD1 CD40LG
17 lymph node disease 29.6 HSPD1 CRP CD40LG
18 meningitis 29.6 NLRP3 IL1B CRP CD40LG
19 sarcoidosis 1 29.6 IL1RN IL1B CRP CD40LG
20 vasculitis 29.5 MEFV HSPD1 CRP CD40LG
21 typhoid fever 29.5 TNFRSF1A IL1B CRP CD40LG
22 kawasaki disease 29.5 IL1B HSPD1 CRP CD40LG
23 gastroenteritis 29.4 NLRP12 IL1RN IL1B CRP
24 juvenile rheumatoid arthritis 29.4 TNFRSF1A IL1RN IL1B CRP
25 miliary tuberculosis 29.4 PDE6B CRP CD40LG
26 pharyngitis 29.4 NLRP3 MVK MEFV IL1RN IL1B FCGR1A
27 acquired immunodeficiency syndrome 29.3 TNFRSF1A IL1B CRP CD40LG
28 wells syndrome 29.2 TNFRSF1A NLRP3 MEFV IL1B CRP
29 exanthem 29.2 NLRP3 MEFV IL1RN CRP CD40LG
30 toxic shock syndrome 29.0 IL1RN IL1B HSPD1 CRP CD40LG
31 autoimmune disease 29.0 IL1RN IL1B HSPD1 CRP CD40LG
32 blau syndrome 28.9 NLRP3 NLRP12 MVK MEFV IL1RN IL1B
33 mycobacterium tuberculosis 1 28.8 TNFRSF1A PDE6B HSPD1 CRP
34 bacterial infectious disease 28.7 IL1RN IL1B HSPD1 FCGR1A CRP CD40LG
35 familial mediterranean fever 28.7 TNFRSF1A NLRP3 MVK MEFV IL1RN IL1B
36 systemic lupus erythematosus 28.0 TNFRSF1A IL1RN IL1B HSPD1 FCGR1A CRP
37 muckle-wells syndrome 27.8 TNFRSF1A NLRP3 NLRP12 MVK MEFV IL1RN
38 prosthetic joint infection 10.5 IL1B CRP
39 uremic pruritus 10.4 IL1B CRP
40 psoriatic juvenile idiopathic arthritis 10.4 NLRP3 MEFV
41 lymphadenitis 10.4
42 amyloidosis aa 10.4 MEFV CRP
43 systemic onset juvenile idiopathic arthritis 10.4 IL1RN IL1B
44 indolent myeloma 10.4 IL1RN IL1B
45 meningococcemia 10.4 IL1RN IL1B
46 osteosclerotic myeloma 10.3 IL1B CD40LG
47 juvenile ankylosing spondylitis 10.3 MEFV IL1RN
48 inflammatory bowel disease 23 10.3 IL1RN CRP
49 tonsillitis 10.3
50 anthracosis 10.3 NLRP3 CARD8

Graphical network of the top 20 diseases related to Cervical Adenitis:



Diseases related to Cervical Adenitis

Symptoms & Phenotypes for Cervical Adenitis

MGI Mouse Phenotypes related to Cervical Adenitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.91 CD40LG FCGR1A HSPD1 IL1RN MEFV NLRP12
2 hematopoietic system MP:0005397 9.81 CD40LG FCGR1A IL1B IL1RN MEFV NLRP12
3 immune system MP:0005387 9.61 CD40LG CRP FCGR1A IL1B IL1RN MEFV
4 integument MP:0010771 9.17 CD40LG IL1B IL1RN MEFV NLRP3 PDE6B

Drugs & Therapeutics for Cervical Adenitis

Drugs for Cervical Adenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies, Monoclonal Phase 1
2 Immunologic Factors Phase 1
3 Antibodies Phase 1
4 Immunoglobulins Phase 1
5 Anti-Bacterial Agents
6 Antibiotics, Antitubercular

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Probiotic Addition to Corticosteroid Treatment for PFAPA Withdrawn NCT02535962 Phase 2
2 Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Recruiting NCT02775994 Phase 1 Canakinumab
3 Rapid Strep Testing in Children With Recent Streptococcal Pharyngitis Completed NCT03055728

Search NIH Clinical Center for Cervical Adenitis

Genetic Tests for Cervical Adenitis

Anatomical Context for Cervical Adenitis

MalaCards organs/tissues related to Cervical Adenitis:

40
Thyroid, Lymph Node, Tonsil, Testes, Myeloid, Lung, Bone

Publications for Cervical Adenitis

Articles related to Cervical Adenitis:

(show top 50) (show all 971)
# Title Authors PMID Year
1
Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome: A debate about diagnosis and treatment in children continues. 61
31866107 2020
2
The immunology of the periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome; what can the tonsils reveal. A literature review. 61
31786522 2020
3
Ethambutol-resistant Mycobacterium kansasii cervical lymphadenitis in an immunocompetent adult patient: A case report and literature review. 61
31890900 2020
4
Performance of recently proposed periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome criteria in a region endemic for familial Mediterranean fever. 61
31346686 2020
5
Surgical management of atypical mycobacterial cervical lymphadenitis in an outbreak of odontological infection. 61
31981916 2020
6
Unilateral acute cervical lymphadenitis in children: can we predict the need for surgery? 61
31470203 2019
7
Suppurative Lymphadenitis after Radioactive Iodine Therapy for Graves' Disease: A Rare Complication? 61
31934559 2019
8
Phenotypes and genotypes of Chinese adult patients with systemic autoinflammatory diseases. 61
31155445 2019
9
Immune Dysregulation in the Tonsillar Microenvironment of Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis (PFAPA) Syndrome. 61
31807979 2019
10
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). 61
31886897 2019
11
Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis in Chinese adult patients. 61
31603071 2019
12
Kimura disease: a case report of a rare illness presenting as a common complaint. 61
30808157 2019
13
[Recurrent infections of the upper aerodigestive tract in patients with primary immunodeficiency]. 61
31119330 2019
14
Characterization of a Candida albicans isolate from a recurrent cervical lymphadenitis patient. 61
31622176 2019
15
Imaging Strategies and Outcomes in Children Hospitalized with Cervical Lymphadenitis. 61
31891560 2019
16
Kikuchi-Fujimoto Disease in Children: An Important Diagnostic Consideration for Cervical Lymphadenitis. 61
31610000 2019
17
[PFAPA syndrome - An important differential diagnosis in children with recurrent fever]. 61
31661147 2019
18
A 19-month-old Boy With Refractory Cervical Adenitis. 61
31568146 2019
19
Surgical outcomes and unique histological features of tonsils after tonsillectomy in adults with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. 61
31495531 2019
20
Clinical features and new diagnostic criteria for the syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis. 61
31131563 2019
21
Mycobacterium scrofulaceum disease: experience from a tertiary medical centre and review of the literature. 61
31264491 2019
22
Towards better diagnostic criteria for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome. 61
30901126 2019
23
Clinical characteristics in a sentinel case as well as in a cluster of tularemia patients associated with grape harvest. 61
31071480 2019
24
Nontuberculous lymphadenitis in children: What management strategy? 61
31039497 2019
25
IL-1β blockade in periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome: case-based review. 61
31324971 2019
26
Juvenile-Onset Immunodeficiency Secondary to Anti-Interferon-Gamma Autoantibodies. 61
31177358 2019
27
A Rare Complication of Oropharyngeal Tularemia: Dacryocystitis 61
31245979 2019
28
Submandibular Lymphadenitis in an Immunocompetent Female: Microbiological Confirmation is Need of the Hour. 61
31218965 2019
29
Vitamin D deficiency as a risk factor for PFAPA syndrome. 61
30870794 2019
30
Role of Mycobacterium avium lysate INF-γ, IL-17, and IL-2 ELISPOT assays in diagnosing nontuberculous mycobacteria lymphadenitis in children. 61
30834995 2019
31
Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome: main features and an algorithm for clinical practice. 61
30798384 2019
32
Recurrence of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome after tonsillectomy: case-based review. 61
31020337 2019
33
Management of Arterial Pseudoaneurysms of the Neck in a Pediatric Population: An Endovascular Case Series and Review of Literature. 61
30684708 2019
34
A rare case of lymphadenitis and pulmonary disease caused by Mycobacterium paraffinicum. 61
30906560 2019
35
Suppurative Cervical Adenitis Due to Streptococcus pneumoniae Infection in Systemic Lupus Erythematosus. 61
30998569 2019
36
From uncertainty to gradually managing and awaiting recovery of a periodic condition- a qualitative study of parents´ experiences of PFAPA syndrome. 61
30961562 2019
37
Chronic Neutropenia in Children With Abscess Forming Cervical Lymphadenitis Caused by Staphylococcus aureus. 61
29613972 2019
38
Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome - PFAPA syndrome. 61
30683466 2019
39
Treatment options for periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome in children and adults: a narrative review. 61
30488366 2019
40
A Case of Adult-Onset Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome Responsive to Tonsillectomy in Japan. 61
31637075 2019
41
Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome persisting to adulthood - an example of a diagnostic and therapeutic challenge. 61
31844343 2019
42
Periodic Fever with Pharyngitis, Aphthous Stomatitis and Cervical Adenitis Syndrome: A Rare Cause of Fever in Adults. 61
30931275 2019
43
Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome (PFAPA): A Clinical Challenge for Primary Care Physicians and Rheumatologists. 61
31334209 2019
44
Incidence of indications for tonsillectomy and frequency of evidence-based surgery: a 12-year retrospective cohort study of primary care electronic records. 61
30397014 2019
45
Predictors of a drainable suppurative adenitis among children presenting with cervical adenopathy. 61
29754963 2019
46
INTERMEDIATE UVEITIS ASSOCIATED WITH PERIODIC FEVER, APHTHOUS STOMATITIS, PHARYNGITIS, AND CERVICAL ADENITIS SYNDROME. 61
28570435 2019
47
Cervical Lymphadenopathy in a Nonagenarian Woman: What to Think? 61
31893203 2019
48
A very rare case of scrofuloderma with multiple cervical lymphadenitis tuberculosis. 61
31049283 2019
49
Mycobacterium lentiflavum as the main cause of lymphadenitis in pediatric population. 61
29395439 2018
50
Lymphadenitis by non-tuberculous mycobacteria in children. 61
30290041 2018

Variations for Cervical Adenitis

Expression for Cervical Adenitis

Search GEO for disease gene expression data for Cervical Adenitis.

Pathways for Cervical Adenitis

GO Terms for Cervical Adenitis

Cellular components related to Cervical Adenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NLRP3 inflammasome complex GO:0072559 8.96 NLRP3 CARD8
2 inflammasome complex GO:0061702 8.62 NLRP3 CARD8

Biological processes related to Cervical Adenitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.92 TNFRSF1A PDE6B NLRP3 NLRP12 IL1RN IL1B
2 innate immune response GO:0045087 9.85 NLRP3 MEFV FCGR1A DEFB112 CRP
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.72 NLRP3 IL1B CD40LG
4 positive regulation of inflammatory response GO:0050729 9.67 TNFRSF1A NLRP12 IL1B
5 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.65 NLRP3 NLRP12 CARD8
6 positive regulation of interleukin-6 production GO:0032755 9.58 IL1RN IL1B HSPD1
7 positive regulation of interleukin-4 production GO:0032753 9.54 NLRP3 CD40LG
8 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.52 NLRP12 IL1B
9 negative regulation of interleukin-1 beta secretion GO:0050713 9.51 NLRP3 CARD8
10 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.46 NLRP3 NLRP12 HSPD1 CARD8
11 regulation of establishment of endothelial barrier GO:1903140 9.43 TNFRSF1A IL1B
12 positive regulation of interleukin-1 beta secretion GO:0050718 9.43 NLRP3 NLRP12 CARD8
13 interleukin-1 beta production GO:0032611 9.37 NLRP3 IL1B
14 negative regulation of inflammatory response GO:0050728 9.35 TNFRSF1A NLRP3 NLRP12 MVK MEFV
15 inflammatory response GO:0006954 9.17 TNFRSF1A NLRP3 MEFV IL1RN IL1B CRP

Molecular functions related to Cervical Adenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008656 8.96 NLRP12 CARD8
2 interleukin-1 receptor binding GO:0005149 8.62 IL1RN IL1B

Sources for Cervical Adenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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