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MCID: CRV013
MIFTS: 35

Cervical Adenoid Cystic Carcinoma

Categories: Cancer diseases, Rare diseases, Reproductive diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Cervical Adenoid Cystic Carcinoma

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MalaCards integrated aliases for Cervical Adenoid Cystic Carcinoma:

Name: Cervical Adenoid Cystic Carcinoma 12 58 15 17 71
Adenoid Cystic Carcinoma of the Cervix Uteri 12 58

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare gynaecological and obstetric diseases


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Disease Ontology 12 DOID:4867
NCIt 49 C6346
ICD10 via Orphanet 33 C53.0 C53.1 C53.8
Orphanet 58 ORPHA213823
UMLS 71 C1332911
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Summaries for Cervical Adenoid Cystic Carcinoma

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Disease Ontology : 12 A cervix carcinoma that is characterized by its resemblance to adenoid cystic carcinoma of the salivary glands. It shows pseudoglandular, cribriform-like and tubular patterns containing basement membrane-like material. Cytologically, the nuclei are angulated and hyperchromatic, without prominent nucleoli.

MalaCards based summary : Cervical Adenoid Cystic Carcinoma, also known as adenoid cystic carcinoma of the cervix uteri, is related to basaloid squamous cell carcinoma and adenoid cystic carcinoma, and has symptoms including pain An important gene associated with Cervical Adenoid Cystic Carcinoma is NFIB (Nuclear Factor I B), and among its related pathways/superpathways are C-MYB transcription factor network and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include cervix and salivary gland, and related phenotype is Decreased viability in esophageal squamous lineage.

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Related Diseases for Cervical Adenoid Cystic Carcinoma

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Diseases related to Cervical Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 basaloid squamous cell carcinoma 30.2 KRT7 CDKN2A
2 adenoid cystic carcinoma 29.0 NFIB MYB KRT7 KIT CDKN2A
3 squamous cell carcinoma 10.3
4 cervix carcinoma 10.3
5 lung adenoid cystic carcinoma 10.2 NFIB KIT
6 rare tumor 10.2
7 breast hemangiopericytoma 10.2 KRT7 KIT
8 heart leiomyosarcoma 10.2 KIT CDKN2A
9 ceruminous adenocarcinoma 10.2 KRT7 KIT
10 adenoid basal cell carcinoma 10.1 KRT7 KIT
11 intratubular embryonal carcinoma 10.1 KRT7 KIT
12 jejunal neoplasm 10.1 KRT7 KIT
13 mucinous stomach adenocarcinoma 10.1 KRT7 KIT
14 warthin tumor 10.1 KRT7 KIT
15 bladder leiomyoma 10.1 KRT7 KIT
16 fibrosarcoma of bone 10.1 KIT CDKN2A
17 thymus clear cell carcinoma 10.1 KRT7 KIT
18 brooke-spiegler syndrome 10.1 NFIB KRT7
19 breast leiomyosarcoma 10.1 KRT7 KIT
20 lipomatosis, multiple 10.1 NFIB KIT
21 mediastinal cancer 10.1 KRT7 KIT
22 ovarian squamous cell carcinoma 10.1 KIT CDKN2A
23 cribriform carcinoma 10.1 KRT7 KIT
24 uterus leiomyosarcoma 10.1 KRT7 KIT
25 lymphoepithelioma-like thymic carcinoma 10.1 KIT CDKN2A
26 ovarian germ cell cancer 10.1 KRT7 KIT
27 thymic carcinoma 10.1 KRT7 KIT
28 adult mesoblastic nephroma 10.1 KRT7 KIT
29 heart cancer 10.1 KRT7 KIT
30 nodular malignant melanoma 10.1 KIT CDKN2A
31 acral lentiginous melanoma 10.1 KIT CDKN2A
32 cervical basaloid squamous cell carcinoma 10.1 KRT7 CDKN2A
33 kidney benign neoplasm 10.1 KRT7 KIT
34 inverted transitional papilloma 10.1 KRT7 CDKN2A
35 endometrial transitional cell carcinoma 10.1 KRT7 CDKN2A
36 anal canal paget's disease 10.1 KRT7 CDKN2A
37 pleomorphic liposarcoma 10.1 KIT CDKN2A
38 perivascular epithelioid cell tumor 10.1 KIT CDKN2A
39 atrophic vulva 10.1 KRT7 CDKN2A
40 ovarian seromucinous carcinoma 10.1 KRT7 CDKN2A
41 mature teratoma 10.1 KRT7 KIT
42 vaginal tubulovillous adenoma 10.1 KRT7 CDKN2A
43 vaginal adenoma 10.1 KRT7 CDKN2A
44 mediastinum sarcoma 10.1 KRT7 CDKN2A
45 pleomorphic carcinoma 10.1 KRT7 KIT
46 plexiform neurofibroma 10.1 KIT CDKN2A
47 vaginal benign neoplasm 10.1 KRT7 CDKN2A
48 neurofibroma 10.1 KIT CDKN2A
49 laryngeal small cell carcinoma 10.1 KRT7 CDKN2A
50 papillary squamous carcinoma 10.1 KRT7 CDKN2A

Graphical network of the top 20 diseases related to Cervical Adenoid Cystic Carcinoma:



Diseases related to Cervical Adenoid Cystic Carcinoma
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Symptoms & Phenotypes for Cervical Adenoid Cystic Carcinoma

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UMLS symptoms related to Cervical Adenoid Cystic Carcinoma:


pain

GenomeRNAi Phenotypes related to Cervical Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.02 CDKN2A KIT KRT7 MYB NFIB
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Drugs & Therapeutics for Cervical Adenoid Cystic Carcinoma

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Chidamide for Advanced Cephalic and Cervical Adenocystic Carcinoma: Evaluation of Efficiency and Safety Recruiting NCT02883374 Phase 2 Chidamide

Search NIH Clinical Center for Cervical Adenoid Cystic Carcinoma

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Genetic Tests for Cervical Adenoid Cystic Carcinoma

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Anatomical Context for Cervical Adenoid Cystic Carcinoma

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MalaCards organs/tissues related to Cervical Adenoid Cystic Carcinoma:

40
Cervix, Salivary Gland
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Publications for Cervical Adenoid Cystic Carcinoma

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Articles related to Cervical Adenoid Cystic Carcinoma:

(show all 12)
# Title Authors PMID Year
1
Aquaporins 1, 3 and 5 in Different Tumors, their Expression, Prognosis Value and Role as New Therapeutic Targets. 61
30927206 2019
2
Adenoid basal carcinoma of the uterine cervix: clinicopathologic features of 12 cases with reference to CD117 expression. 61
22123720 2012
3
Cytologic characteristics of adenoid cystic carcinoma of the cervix uteri--case report. 61
20432755 2010
4
[Clinical analysis of 38 patients with cephalic and cervical adenoid cystic carcinoma]. 61
16494039 2005
5
Cervical adenoid cystic carcinoma coexisting with multiple human papillomavirus-associated genital lesions. A common etiology? 61
10352392 1999
6
A case of uterine cervical adenoid cystic carcinoma: immunohistochemical study for basement membrane material. 61
7724157 1995
7
Adenoid cystic carcinoma of the uterine cervix. Cytologic features. 61
2157320 1990
8
Cervical adenoid cystic carcinoma associated with ascites. 61
2996994 1985
9
Adenoid cystic carcinoma of the uterine cervix: ultrastructure, immunofluorescence, and criteria for diagnosis. 61
6176118 1982
10
[Case of adenoid cystic carcinoma of the cervix uteri coexistent with squamous cell carcinoma]. 61
542348 1979
11
Adenoid cystic carcinoma of the cervix uteri: report of six cases and review of the literature. 61
221309 1979
12
Cytologic characteristics of adenoid cystic carcinoma of the cervix uteri. 61
180737 1976
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Variations for Cervical Adenoid Cystic Carcinoma

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Cosmic variations for Cervical Adenoid Cystic Carcinoma:

9 (show top 50) (show all 1113)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM91852150 ZNF507 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.34C>A p.P12T 19:32352864-32352864 3
2 COSM143041461 WASF2 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.15G>T p.T5= 1:27428876-27428876 3
3 COSM101322987 VWA8 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.4027G>A p.E1343K 13:41689458-41689458 3
4 COSM98138031 VWA5B1 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.1486G>A p.V496I 1:20330897-20330897 3
5 COSM109704473 UNC80 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.305A>G p.Q102R 2:209777264-209777264 3
6 COSM84976380 UBTF salivary gland,NS,carcinoma,adenoid cystic carcinoma c.106A>T p.N36Y 17:44216657-44216657 3
7 COSM84976392 UBTF salivary gland,NS,carcinoma,adenoid cystic carcinoma c.100A>C p.M34L 17:44216663-44216663 3
8 COSM129553208 TXNRD3 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.247A>G p.K83E 3:126647293-126647293 3
9 COSM87028709 TSC2 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.2402C>T p.A801V 16:2074246-2074246 3
10 COSM85719376 TSC1 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.3280G>T p.E1094* 9:132896450-132896450 3
11 COSM85719495 TSC1 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.2684T>A p.V895D 9:132897552-132897552 3
12 COSM84855029 TRPV5 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.554A>G p.H185R 7:142929054-142929054 3
13 COSM99625361 TP53BP1 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.3869C>G p.T1290S 15:43422086-43422086 3
14 COSM88365650 TP53 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.854A>C p.E285A 17:7673766-7673766 3
15 COSM87898351 TP53 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.743G>A p.R248Q 17:7674220-7674220 3
16 COSM87898709 TP53 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.742C>T p.R248W 17:7674221-7674221 3
17 COSM87899497 TP53 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.586C>T p.R196* 17:7674945-7674945 3
18 COSM87900273 TP53 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.427G>A p.V143M 17:7675185-7675185 3
19 COSM87898392 TP53 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.713G>A p.C238Y 17:7674250-7674250 3
20 COSM87899695 TP53 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.715A>G p.N239D 17:7674248-7674248 3
21 COSM95139295 TOMM34 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.555T>A p.P185= 20:44948873-44948873 3
22 COSM101859511 TOM1L2 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.409G>A p.V137I 17:17884726-17884726 3
23 COSM94314138 TIE1 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.2050G>C p.A684P 1:43313257-43313257 3
24 COSM88420642 THRA salivary gland,NS,carcinoma,adenoid cystic carcinoma c.1162C>T p.R388W 17:40093071-40093071 3
25 COSM83999385 TFAP2D salivary gland,NS,carcinoma,adenoid cystic carcinoma c.1306C>T p.R436W 6:50772811-50772811 3
26 COSM96852092 TENT5C salivary gland,NS,carcinoma,adenoid cystic carcinoma c.833T>A p.F278Y 1:117623701-117623701 3
27 COSM96851188 TENT5C salivary gland,NS,carcinoma,adenoid cystic carcinoma c.728G>C p.G243A 1:117623596-117623596 3
28 COSM148021950 TCF7L2 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.883C>T p.P295S 10:113151005-113151005 3
29 COSM84062874 TBX3 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.1528C>T p.Q510* 12:114674407-114674407 3
30 COSM88019822 TBC1D31 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.845T>A p.L282Q 8:123100820-123100820 3
31 COSM87777820 TANGO6 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.1765G>C p.G589R 16:68907540-68907540 3
32 COSM140247567 SUPT5H salivary gland,NS,carcinoma,adenoid cystic carcinoma c.1094G>T p.R365L 19:39468812-39468812 3
33 COSM93863315 STXBP3 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.1275G>C p.R425S 1:108796645-108796645 3
34 COSM86749613 STAG2 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.2405T>G p.I802S 23:124071195-124071195 3
35 COSM99817142 SPEN salivary gland,NS,carcinoma,adenoid cystic carcinoma c.4207C>T p.R1403* 1:15930447-15930447 3
36 COSM88093366 SOX9 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.1457T>A p.V486D 17:72124314-72124314 3
37 COSM98682928 SOX6 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.630T>C p.D210= 11:16186861-16186861 3
38 COSM84674496 SMO salivary gland,NS,carcinoma,adenoid cystic carcinoma c.385G>C p.V129L 7:129203437-129203437 3
39 COSM89651491 SMARCA4 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.2372C>T p.A791V 19:11013046-11013046 3
40 COSM100421709 SMARCA2 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.3476G>T p.R1159L 9:2115841-2115841 3
41 COSM100403983 SMARCA2 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.2564G>A p.R855Q 9:2086866-2086866 3
42 COSM100406359 SMARCA2 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.4582T>A p.S1528T 9:2186216-2186216 3
43 COSM98238051 SLC66A1 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.719A>C p.E240A 1:19327327-19327327 3
44 COSM87293136 SLC26A2 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.1474C>T p.R492W 5:149981067-149981067 3
45 COSM93523617 SLC26A11 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.1196T>C p.F399S 17:80246551-80246551 3
46 COSM103755170 SLC25A13 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.888G>A p.L296= 7:96189339-96189339 3
47 COSM90158697 SLC15A5 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.925C>G p.L309V 12:16244630-16244630 3
48 COSM86801307 SIK2 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.1387G>A p.E463K 11:111719895-111719895 3
49 COSM97203718 SGPL1 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.1159T>G p.Y387D 10:70873450-70873450 3
50 COSM89628192 SF3B1 salivary gland,NS,carcinoma,adenoid cystic carcinoma c.3254C>T p.A1085V 2:197397997-197397997 3
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Expression for Cervical Adenoid Cystic Carcinoma

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Search GEO for disease gene expression data for Cervical Adenoid Cystic Carcinoma.
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Pathways for Cervical Adenoid Cystic Carcinoma

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Pathways related to Cervical Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
C-MYB transcription factor network 1
11.15 MYB KIT
2
Dendritic Cells Developmental Lineage Pathway 64
11.02 KIT CD1C
3
Pathways Affected in Adenoid Cystic Carcinoma 1
10.78 NFIB MYB
4
B Cell Development Pathways 64
10.35 KIT CD1C
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GO Terms for Cervical Adenoid Cystic Carcinoma

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Biological processes related to Cervical Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 somatic stem cell division GO:0048103 8.62 KIT CDKN2A
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Sources for Cervical Adenoid Cystic Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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