MCID: CRV014
MIFTS: 28

Cervical Adenoma Malignum

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervical Adenoma Malignum

MalaCards integrated aliases for Cervical Adenoma Malignum:

Name: Cervical Adenoma Malignum 12 15
Cervical Mucinous Adenocarcinoma, Minimal Deviation Variant 71

Classifications:



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Disease Ontology 12 DOID:6627
NCIt 49 C40206
UMLS 71 C1516423

Summaries for Cervical Adenoma Malignum

Disease Ontology : 12 A cervical mucinous adenocarcinoma that is well differentiated, consisting of an endocervical glandular hyperplasia of lobular architecture resembling glands but with the characteristics of adenocarcinoma.

MalaCards based summary : Cervical Adenoma Malignum, also known as cervical mucinous adenocarcinoma, minimal deviation variant, is related to ovarian sex-cord stromal tumor and adenoma. An important gene associated with Cervical Adenoma Malignum is RAB8A (RAB8A, Member RAS Oncogene Family), and among its related pathways/superpathways are Cytoskeletal Signaling and DNA Damage. Affiliated tissues include breast, colon and skin, and related phenotype is cellular.

Related Diseases for Cervical Adenoma Malignum

Diseases related to Cervical Adenoma Malignum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 ovarian sex-cord stromal tumor 30.7 MME KRT7
2 adenoma 29.3 MSH6 MSH2 MLH1 KRT7
3 peutz-jeghers syndrome 10.4
4 bartholin's duct cyst 10.3 HMGA2 CALD1
5 vulvar leiomyoma 10.3 HMGA2 CALD1
6 mucinous adenocarcinoma 10.3
7 appendix adenocarcinoma 10.3
8 mesenchymoma 10.3 HMGA2 CALD1
9 bone leiomyosarcoma 10.3 KRT7 CALD1
10 nephrogenic adenofibroma 10.3 KRT7 CALD1
11 infiltrating angiolipoma 10.3 HMGA2 CALD1
12 vaginal tubulovillous adenoma 10.2 STK11 KRT7
13 vaginal adenoma 10.2 STK11 KRT7
14 mixed endometrial stromal and smooth muscle tumor 10.2 MME CALD1
15 fallopian tube leiomyoma 10.2 MME CALD1
16 urethra leiomyoma 10.2 MME CALD1
17 sarcomatous intrahepatic cholangiocarcinoma 10.2 KRT7 CALD1
18 fallopian tube benign neoplasm 10.2 MME CALD1
19 breast myofibroblastoma 10.2 MME CALD1
20 bladder leiomyoma 10.2 KRT7 CALD1
21 lung combined type small cell carcinoma 10.2 MME CALD1
22 intravenous leiomyomatosis 10.2 MME CALD1
23 vulvar benign neoplasm 10.2 HMGA2 CALD1
24 sarcomatoid squamous cell skin carcinoma 10.2 MME CALD1
25 cervical polyp 10.2 MME CALD1
26 breast leiomyosarcoma 10.2 KRT7 CALD1
27 benign peritoneal mesothelioma 10.2 KRT7 CALD1
28 endobronchial lipoma 10.2 KRT7 CALD1
29 vaginal endometrial stromal sarcoma 10.2 MME CALD1
30 cellular leiomyoma 10.2 MME CALD1
31 benign mesenchymoma 10.2 KRT7 HMGA2
32 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.2 STK11 HMGA2
33 uterus leiomyosarcoma 10.2 KRT7 CALD1
34 endobronchial leiomyoma 10.2 MME CALD1
35 vagina sarcoma 10.2 MME CALD1
36 vaginal cancer 10.2 KRT7 CALD1
37 nephrogenic adenoma of urinary bladder 10.1 MME KRT7
38 adenofibroma 10.1 MME KRT7
39 wolffian duct adenoma 10.1 MME KRT7
40 mixed epithelial stromal tumour 10.1 MME KRT7
41 female urethral cancer 10.1 MME KRT7
42 epididymal neoplasm 10.1 MME KRT7
43 ovarian wilms' cancer 10.1 MME KRT7
44 transverse colon cancer 10.1 MLH1 KRT7
45 clear cell papillary renal cell carcinoma 10.1 MME KRT7
46 chromophil adenoma of the kidney 10.1 MME KRT7
47 eccrine papillary adenocarcinoma 10.1 MME KRT7
48 clear cell hidradenoma 10.1 MME KRT7
49 hidradenoma 10.1 MME KRT7
50 wolffian duct adenocarcinoma 10.1 MME KRT7

Graphical network of the top 20 diseases related to Cervical Adenoma Malignum:



Diseases related to Cervical Adenoma Malignum

Symptoms & Phenotypes for Cervical Adenoma Malignum

MGI Mouse Phenotypes related to Cervical Adenoma Malignum:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.17 KRT7 MLH1 MME MSH2 MSH6 RAB8A

Drugs & Therapeutics for Cervical Adenoma Malignum

Search Clinical Trials , NIH Clinical Center for Cervical Adenoma Malignum

Genetic Tests for Cervical Adenoma Malignum

Anatomical Context for Cervical Adenoma Malignum

MalaCards organs/tissues related to Cervical Adenoma Malignum:

40
Breast, Colon, Skin, Smooth Muscle, Small Intestine, Kidney, Ovary

Publications for Cervical Adenoma Malignum

Articles related to Cervical Adenoma Malignum:

# Title Authors PMID Year
1
BRCA and Beyond: Comprehensive Image-rich Review of Hereditary Breast and Gynecologic Cancer Syndromes. 61
32031911 2020
2
Do hereditary syndrome-related gynecologic cancers have any specific features? 61
26337050 2015
3
[Peutz-Jeghers syndrome complicated by cervical adenoma malignum and ovarian sex cord tumor with annular tubules: report of a case]. 61
17374267 2006
4
Recent advances in immunohistochemistry in gynaecological pathology. 61
11943015 2002
5
Disseminated cervical adenoma malignum and bilateral ovarian sex cord tumors with annular tubules associated with Peutz-Jeghers syndrome. 61
8188091 1994
6
Peutz-Jeghers syndrome with ovarian sex cord tumor with annular tubules and cervical adenoma malignum. 61
1612512 1992
7
Peutz-Jeghers syndrome with ovarian sex cord tumor with annular tubules and cervical adenoma malignum. 61
1916514 1991

Variations for Cervical Adenoma Malignum

Expression for Cervical Adenoma Malignum

Search GEO for disease gene expression data for Cervical Adenoma Malignum.

Pathways for Cervical Adenoma Malignum

GO Terms for Cervical Adenoma Malignum

Cellular components related to Cervical Adenoma Malignum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutSalpha complex GO:0032301 8.96 MSH6 MSH2
2 mismatch repair complex GO:0032300 8.8 MSH6 MSH2 MLH1

Biological processes related to Cervical Adenoma Malignum according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.83 STK11 MSH6 MSH2 MLH1
2 determination of adult lifespan GO:0008340 9.54 MSH6 MSH2
3 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.54 MSH6 MSH2 MLH1
4 negative regulation of DNA recombination GO:0045910 9.51 MSH6 MSH2
5 positive regulation of isotype switching to IgG isotypes GO:0048304 9.49 MSH2 MLH1
6 cellular response to UV-B GO:0071493 9.48 STK11 MME
7 positive regulation of helicase activity GO:0051096 9.46 MSH6 MSH2
8 positive regulation of isotype switching to IgA isotypes GO:0048298 9.43 MSH2 MLH1
9 mismatch repair GO:0006298 9.43 MSH6 MSH2 MLH1
10 maintenance of DNA repeat elements GO:0043570 9.4 MSH6 MSH2
11 isotype switching GO:0045190 9.33 MSH6 MSH2 MLH1
12 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.32 MSH2 MLH1
13 somatic hypermutation of immunoglobulin genes GO:0016446 9.13 MSH6 MSH2 MLH1
14 somatic recombination of immunoglobulin gene segments GO:0016447 8.8 MSH6 MSH2 MLH1

Molecular functions related to Cervical Adenoma Malignum according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.63 MSH6 MSH2 MLH1
2 magnesium ion binding GO:0000287 9.61 STK11 MSH6 MSH2
3 DNA-dependent ATPase activity GO:0008094 9.49 MSH6 MSH2
4 ADP binding GO:0043531 9.48 MSH6 MSH2
5 four-way junction DNA binding GO:0000400 9.4 MSH6 MSH2
6 MutLalpha complex binding GO:0032405 9.37 MSH6 MSH2
7 oxidized purine DNA binding GO:0032357 9.32 MSH6 MSH2
8 single guanine insertion binding GO:0032142 9.26 MSH6 MSH2
9 single thymine insertion binding GO:0032143 9.16 MSH6 MSH2
10 mismatched DNA binding GO:0030983 9.13 MSH6 MSH2 MLH1
11 guanine/thymine mispair binding GO:0032137 8.8 MSH6 MSH2 MLH1

Sources for Cervical Adenoma Malignum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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