MCID: CRV028
MIFTS: 34

Cervical Adenosarcoma

Categories: Cancer diseases, Reproductive diseases
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Aliases & Classifications for Cervical Adenosarcoma

MalaCards integrated aliases for Cervical Adenosarcoma:

Name: Cervical Adenosarcoma 11 14 71
Cervical Muellerian Adenosarcoma 11
Cervical Mullerian Adenosarcoma 11

Classifications:



External Ids:

Disease Ontology 11 DOID:4111
NCIt 49 C40229
SNOMED-CT 68 764847000
UMLS 71 C1516426

Summaries for Cervical Adenosarcoma

Disease Ontology: 11 A cervical carcinosarcoma that is located in the cervix.

MalaCards based summary: Cervical Adenosarcoma, also known as cervical muellerian adenosarcoma, is related to sarcoma and adenosarcoma. An important gene associated with Cervical Adenosarcoma is MYOG (Myogenin), and among its related pathways/superpathways are Hematopoietic Stem Cells and Lineage-specific Markers and Mesenchymal Stem Cells and Lineage-specific Markers. The drugs Bevacizumab and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include cervix and endothelial, and related phenotypes are homeostasis/metabolism and neoplasm

Related Diseases for Cervical Adenosarcoma

Diseases related to Cervical Adenosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 365)
# Related Disease Score Top Affiliating Genes
1 sarcoma 29.8 WT1 TP53 SUZ12 MYOG MYOD1
2 adenosarcoma 29.4 TP53 PGR MME JAZF1 ESR1 CALD1
3 adenosarcoma of the cervix uteri 11.3
4 uterine inversion 10.4 MYOG MME
5 heart lymphoma 10.3 MYOG MME
6 inverted follicular keratosis 10.3 GP6 GP5
7 middle ear squamous cell carcinoma 10.3 GP6 GP5
8 penis basal cell carcinoma 10.3 GP6 GP5
9 cervical adenomyoma 10.3 PGR MME
10 cervical benign neoplasm 10.3 PGR MME
11 nipple carcinoma 10.3 PGR ESR1
12 breast mucinous cystadenocarcinoma 10.3 PGR ESR1
13 breast fibroadenosis 10.3 PGR ESR1
14 oral rhabdomyosarcoma 10.3 MYOG MYOD1
15 adult type testicular granulosa cell tumor 10.3 PGR MME
16 bulbospinal polio 10.3 PGR ESR1
17 spinal polio 10.3 PGR ESR1
18 glycogen-rich clear cell breast carcinoma 10.3 PGR ESR1
19 adult cystic nephroma 10.3 PGR ESR1
20 gallbladder sarcoma 10.3 MYOG MYOD1
21 benign breast adenomyoepithelioma 10.3 MME ESR1
22 breast cystic hypersecretory carcinoma 10.3 PGR ESR1
23 pineal region teratoma 10.3 MYOG MYOD1
24 uterine sarcoma 10.3 MME ESR1
25 oncocytic breast carcinoma 10.3 PGR ESR1
26 breast squamous cell carcinoma 10.3 PGR ESR1
27 skeletal muscle neoplasm 10.3 MYOG MYOD1
28 progesterone resistance 10.3 PGR ESR1
29 vaginal endometrial stromal tumor 10.3 MME CALD1
30 mixed endometrial stromal and smooth muscle tumor 10.3 MME CALD1
31 fallopian tube leiomyoma 10.3 MME CALD1
32 urethra leiomyoma 10.3 MME CALD1
33 breast papillary carcinoma 10.3 PGR ESR1
34 prostate rhabdomyosarcoma 10.3 MYOG MYOD1
35 fallopian tube benign neoplasm 10.3 MME CALD1
36 central nervous system mesenchymal non-meningothelial tumor 10.3 MYOG MYOD1
37 ectomesenchymoma 10.3 MYOG MYOD1
38 vulvar syringoma 10.3 PGR ESR1
39 overgrowth syndrome 10.3
40 myoblastoma 10.3 MYOG MYOD1
41 lipid-rich carcinoma 10.3 PGR ESR1
42 subareolar duct papillomatosis 10.3 MME CALD1
43 nipple benign neoplasm 10.3 MME CALD1
44 conventional leiomyosarcoma 10.3 MYOG CALD1
45 breast adenoid cystic carcinoma 10.3 PGR ESR1
46 progesterone-receptor negative breast cancer 10.3 PGR ESR1
47 lung leiomyoma 10.3 PGR CALD1
48 progesterone-receptor positive breast cancer 10.3 PGR ESR1
49 polyp of corpus uteri 10.3 PGR ESR1
50 microglandular adenosis 10.3 PGR ESR1

Graphical network of the top 20 diseases related to Cervical Adenosarcoma:



Diseases related to Cervical Adenosarcoma

Symptoms & Phenotypes for Cervical Adenosarcoma

MGI Mouse Phenotypes related to Cervical Adenosarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 CD34 ESR1 GP5 GP6 JAZF1 MAPK8IP1
2 neoplasm MP:0002006 10.01 CD34 ESR1 MYOD1 PGR PMS2 SUZ12
3 cellular MP:0005384 9.9 CD34 ESR1 JAZF1 MAPK8IP1 MME MYOG
4 muscle MP:0005369 9.87 CALD1 ESR1 MYOD1 MYOG PGR TP53
5 no phenotypic analysis MP:0003012 9.85 ESR1 MYOD1 MYOG PGR TP53 WT1
6 reproductive system MP:0005389 9.61 ESR1 GP6 JAZF1 MAPK8IP1 MYOD1 PGR
7 mortality/aging MP:0010768 9.4 CALD1 ESR1 GP6 JAZF1 MAPK8IP1 MYOD1

Drugs & Therapeutics for Cervical Adenosarcoma

Drugs for Cervical Adenosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 1 216974-75-3 135329020
2
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
3 Immunoglobulins, Intravenous Phase 1
4 Albumin-Bound Paclitaxel Phase 1
5 Immunoglobulins Phase 1
6 Antimitotic Agents Phase 1
7 Immunoglobulin G Phase 1
8 Angiogenesis Inhibitors Phase 1
9 Tubulin Modulators Phase 1
10 Antibodies, Monoclonal Phase 1
11 Antibodies Phase 1
12 Antineoplastic Agents, Immunological Phase 1
13 Immunologic Factors Phase 1
14 Endothelial Growth Factors Phase 1
15 Mitogens Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Targeted Complex Therapy for Advanced Melanoma, Gynecologic Cancers, and Other Malignancies: Nab-Paclitaxel (Abraxane)/Bevacizumab Complex (AB-Complex) Recruiting NCT02020707 Phase 1 Nab-paclitaxel

Search NIH Clinical Center for Cervical Adenosarcoma

Genetic Tests for Cervical Adenosarcoma

Anatomical Context for Cervical Adenosarcoma

Organs/tissues related to Cervical Adenosarcoma:

FMA: Cervix
MalaCards : Cervix, Endothelial

Publications for Cervical Adenosarcoma

Articles related to Cervical Adenosarcoma:

(show all 20)
# Title Authors PMID Year
1
Uterine Cervical Adenosarcoma Showing an Endophytic Growth Pattern. 62
36128067 2022
2
Unusual uterine cervical polypoid mass presenting during pregnancy. 62
34890128 2022
3
Clinicopathologic characteristics and oncologic outcomes in adenosarcoma of gynecologic sites. 62
35005157 2022
4
Management and survival of patients with Mullerian adenosarcoma of the cervix without sarcomatous overgrowth desiring fertility preservation, a case report and review of the literature. 62
32181315 2020
5
Uterine and Cervical Adenosarcoma: A Retrospective Study of Overall Oncologic Outcomes and Fertility Preservation in Early-Stage Disease. 62
31127022 2019
6
[HIGH GRADE ADENOSARCOMA OF ENDOCERVIX AND ENDOMETRIAL CAVITY WITH A HETEROLOGOUS COMPONENT OF RHABDOMYOSARCOMA. CASE REPORT AND REVIEW OF THE LITERATURE]. 62
31613077 2019
7
Uterine Adenosarcoma: A Retrospective 12-Year Single-Center Study. 62
31139558 2019
8
Clinical management of uterine cervical mullerian adenosarcoma: A clinicopathological study of six cases and review of the literature. 62
30122564 2018
9
[Mullerian adenosarcoma of the cervix: case report with conservative management]. 62
29809188 2018
10
Case Report of Successful Childbearing after Conservative Surgery for Cervical Mullerian Adenosarcoma. 62
28154764 2017
11
Mullerian adenosarcoma of the cervix: Report of two large tumors with sarcomatous overgrowth or heterologous elements. 62
25426405 2014
12
Mullerian adenosaroma of the cervix with sarcomatous overgrowth and heterologous elements presenting as a recurrent cervical polyp. 62
22953093 2012
13
Cervical Mullerian adenosarcoma with heterologous sarcomatous overgrowth: a fourth case and review of literature. 62
21663687 2011
14
Mullerian adenosarcoma of the uterine cervix in an adolescent girl. 62
19643645 2010
15
Human papillomaviruses do not play an aetiological role in Müllerian adenosarcomas of the uterine cervix. 62
18552169 2008
16
Immunohistochemical determination of estrogen and progesterone receptor positivity in uterine adenosarcoma. 62
15196864 2004
17
Mullerian adenosarcoma of the uterine cervix. 62
12024940 2001
18
Adenosarcoma of the uterine cervix: a clinicopathological study of 12 cases. 62
8600073 1995
19
Mullerian adenosarcoma of the uterine cervix. 62
2846415 1988
20
Cervical mullerian adenosarcoma: case report. 62
6299743 1982

Variations for Cervical Adenosarcoma

Expression for Cervical Adenosarcoma

Search GEO for disease gene expression data for Cervical Adenosarcoma.

Pathways for Cervical Adenosarcoma

Pathways related to Cervical Adenosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 MME GP5 CD34
2 10.78 MYOG MYOD1 CD34
3 10.54 PGR ESR1
4 10.07 PGR ESR1

GO Terms for Cervical Adenosarcoma

Biological processes related to Cervical Adenosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of DNA-templated transcription GO:0006355 10.11 WT1 TP53 PGR MYOG MYOD1 MAPK8IP1
2 intracellular steroid hormone receptor signaling pathway GO:0030518 9.76 PGR ESR1
3 positive regulation of skeletal muscle fiber development GO:0048743 9.71 MYOG MYOD1
4 paracrine signaling GO:0038001 9.56 PGR CD34
5 negative regulation of miRNA maturation GO:1903799 9.5 ESR1 TP53
6 muscle cell fate commitment GO:0042693 9.46 MYOG MYOD1
7 myotube differentiation GO:0014902 9.43 MYOG MYOD1
8 positive regulation of RNA polymerase II transcription preinitiation complex assembly GO:0045899 9.26 TP53 ESR1
9 cellular response to estradiol stimulus GO:0071392 9.1 MYOG MYOD1 ESR1

Molecular functions related to Cervical Adenosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.85 WT1 TP53 PGR MYOG MYOD1 ESR1
2 promoter-specific chromatin binding GO:1990841 9.8 TP53 SUZ12 MYOD1
3 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.73 WT1 TP53 PGR MYOG MYOD1 ESR1
4 cis-regulatory region sequence-specific DNA binding GO:0000987 9.56 TP53 MYOG MYOD1
5 sequence-specific DNA binding GO:0043565 9.23 WT1 SUZ12 PGR MYOG MYOD1 ESR1

Sources for Cervical Adenosarcoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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