MCID: CRV028
MIFTS: 34

Cervical Adenosarcoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervical Adenosarcoma

MalaCards integrated aliases for Cervical Adenosarcoma:

Name: Cervical Adenosarcoma 12 15 70
Cervical Muellerian Adenosarcoma 12
Cervical Mullerian Adenosarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4111
NCIt 50 C40229
SNOMED-CT 67 764847000
UMLS 70 C1516426

Summaries for Cervical Adenosarcoma

Disease Ontology : 12 A cervical carcinosarcoma that is located in the cervix.

MalaCards based summary : Cervical Adenosarcoma, also known as cervical muellerian adenosarcoma, is related to adenosarcoma and adenosarcoma of the cervix uteri. An important gene associated with Cervical Adenosarcoma is GP5 (Glycoprotein V Platelet), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. Affiliated tissues include cervix, breast and lung, and related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Cervical Adenosarcoma

Diseases related to Cervical Adenosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 350)
# Related Disease Score Top Affiliating Genes
1 adenosarcoma 29.7 TP53 PGR MME JAZF1 ESR1
2 adenosarcoma of the cervix uteri 11.3
3 inverted follicular keratosis 10.4 GP6 GP5
4 cervical adenomyoma 10.4 PGR MME
5 cervical benign neoplasm 10.4 PGR MME
6 heart lymphoma 10.4 MYOG MME
7 fallopian tube endometriosis 10.4 PGR MME
8 cervical serous adenocarcinoma 10.4 PGR MME
9 glassy cell carcinoma of the cervix 10.4 PGR ESR1
10 breast intraductal papillomatosis 10.4 PGR ESR1
11 nipple carcinoma 10.4 PGR ESR1
12 bartholin's gland adenoid cystic carcinoma 10.4 PGR ESR1
13 chronic tympanitis 10.4 PGR ESR1
14 focal epithelial hyperplasia 10.4 GP6 GP5
15 granulomatous endometritis 10.4 PGR ESR1
16 vulvar syringoma 10.4 PGR ESR1
17 vaginal endometrial stromal tumor 10.4 MME CALD1
18 mixed endometrial stromal and smooth muscle tumor 10.4 MME CALD1
19 adult cystic nephroma 10.4 PGR MME
20 fallopian tube leiomyoma 10.4 MME CALD1
21 urethra leiomyoma 10.4 MME CALD1
22 fallopian tube benign neoplasm 10.4 MME CALD1
23 adult type testicular granulosa cell tumor 10.4 PGR ESR1
24 breast scirrhous carcinoma 10.4 PGR ESR1
25 oncocytic breast carcinoma 10.4 PGR ESR1
26 subareolar duct papillomatosis 10.3 MME CALD1
27 cervical mucinous adenocarcinoma 10.3 MME CALD1
28 nipple benign neoplasm 10.3 MME CALD1
29 breast papillary carcinoma 10.3 PGR ESR1
30 diffuse peritoneal leiomyomatosis 10.3 PGR CALD1
31 wolffian duct adenocarcinoma 10.3 MME ESR1
32 breast adenoid cystic carcinoma 10.3 PGR ESR1
33 pineal region teratoma 10.3 MYOG MYOD1
34 pancreatic mucinous cystadenoma 10.3 PGR MME
35 skeletal muscle neoplasm 10.3 MYOG MYOD1
36 breast adenoma 10.3 PGR ESR1
37 uterus perivascular epithelioid cell tumor 10.3 MME CALD1
38 gallbladder sarcoma 10.3 MYOG MYOD1
39 prostate rhabdomyosarcoma 10.3 MYOG MYOD1
40 lipid-rich carcinoma 10.3 PGR ESR1
41 central nervous system mesenchymal non-meningothelial tumor 10.3 MYOG MYOD1
42 cutaneous adenocystic carcinoma 10.3 PGR MME
43 malignant triton tumor 10.3 MYOG MYOD1
44 epididymal neoplasm 10.3 MYOD1 MME
45 basaloid lung carcinoma 10.3 TP53 PGR
46 atypical polypoid adenomyoma 10.3 MME CALD1
47 squamous cell papilloma 10.3 TP53 GP5
48 penile benign neoplasm 10.3 TP53 GP5
49 progesterone-receptor negative breast cancer 10.3 PGR ESR1
50 apocrine adenosis of breast 10.3 TP53 PGR

Graphical network of the top 20 diseases related to Cervical Adenosarcoma:



Diseases related to Cervical Adenosarcoma

Symptoms & Phenotypes for Cervical Adenosarcoma

MGI Mouse Phenotypes related to Cervical Adenosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.11 CD34 DICER1 ESR1 MME MSH2 MSH6
2 homeostasis/metabolism MP:0005376 10.07 CD34 DICER1 ESR1 GP5 GP6 MME
3 hematopoietic system MP:0005397 10.02 CD34 DICER1 ESR1 GP6 MSH2 MSH6
4 immune system MP:0005387 9.9 CD34 DICER1 ESR1 GP6 MME MSH2
5 integument MP:0010771 9.65 CD34 DICER1 ESR1 GP6 MME MSH2
6 neoplasm MP:0002006 9.32 CD34 DICER1 ESR1 MSH2 MSH6 MYOD1

Drugs & Therapeutics for Cervical Adenosarcoma

Search Clinical Trials , NIH Clinical Center for Cervical Adenosarcoma

Genetic Tests for Cervical Adenosarcoma

Anatomical Context for Cervical Adenosarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Cervical Adenosarcoma:

19
Cervix

MalaCards organs/tissues related to Cervical Adenosarcoma:

40
Breast, Cervix, Lung, Colon, Skin, Uterus, Prostate

Publications for Cervical Adenosarcoma

Articles related to Cervical Adenosarcoma:

(show all 17)
# Title Authors PMID Year
1
Management and survival of patients with Mullerian adenosarcoma of the cervix without sarcomatous overgrowth desiring fertility preservation, a case report and review of the literature. 61
32181315 2020
2
Uterine and Cervical Adenosarcoma: A Retrospective Study of Overall Oncologic Outcomes and Fertility Preservation in Early-Stage Disease. 61
31127022 2019
3
[HIGH GRADE ADENOSARCOMA OF ENDOCERVIX AND ENDOMETRIAL CAVITY WITH A HETEROLOGOUS COMPONENT OF RHABDOMYOSARCOMA. CASE REPORT AND REVIEW OF THE LITERATURE]. 61
31613077 2019
4
Uterine Adenosarcoma: A Retrospective 12-Year Single-Center Study. 61
31139558 2019
5
Clinical management of uterine cervical mullerian adenosarcoma: A clinicopathological study of six cases and review of the literature. 61
30122564 2018
6
[Mullerian adenosarcoma of the cervix: case report with conservative management]. 61
29809188 2018
7
Case Report of Successful Childbearing after Conservative Surgery for Cervical Mullerian Adenosarcoma. 61
28154764 2017
8
Mullerian adenosarcoma of the cervix: Report of two large tumors with sarcomatous overgrowth or heterologous elements. 61
25426405 2014
9
Mullerian adenosaroma of the cervix with sarcomatous overgrowth and heterologous elements presenting as a recurrent cervical polyp. 61
22953093 2012
10
Cervical Mullerian adenosarcoma with heterologous sarcomatous overgrowth: a fourth case and review of literature. 61
21663687 2011
11
Mullerian adenosarcoma of the uterine cervix in an adolescent girl. 61
19643645 2010
12
Human papillomaviruses do not play an aetiological role in Müllerian adenosarcomas of the uterine cervix. 61
18552169 2008
13
Immunohistochemical determination of estrogen and progesterone receptor positivity in uterine adenosarcoma. 61
15196864 2004
14
Mullerian adenosarcoma of the uterine cervix. 61
12024940 2001
15
Adenosarcoma of the uterine cervix: a clinicopathological study of 12 cases. 61
8600073 1995
16
Mullerian adenosarcoma of the uterine cervix. 61
2846415 1988
17
Cervical mullerian adenosarcoma: case report. 61
6299743 1982

Variations for Cervical Adenosarcoma

Expression for Cervical Adenosarcoma

Search GEO for disease gene expression data for Cervical Adenosarcoma.

Pathways for Cervical Adenosarcoma

GO Terms for Cervical Adenosarcoma

Cellular components related to Cervical Adenosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.85 TP53 SUZ12 PMS2 PGR MYOG MYOD1
2 MutSalpha complex GO:0032301 8.96 MSH6 MSH2
3 mismatch repair complex GO:0032300 8.8 PMS2 MSH6 MSH2

Biological processes related to Cervical Adenosarcoma according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 myoblast differentiation GO:0045445 9.59 MYOG MYOD1
2 replicative senescence GO:0090399 9.58 TP53 MME
3 negative regulation of DNA recombination GO:0045910 9.58 MSH6 MSH2
4 isotype switching GO:0045190 9.57 MSH6 MSH2
5 myotube differentiation GO:0014902 9.56 MYOG MYOD1
6 protein localization to chromatin GO:0071168 9.55 MSH2 ESR1
7 negative regulation of gene expression GO:0010629 9.55 TP53 PGR ESR1 DICER1 CD34
8 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.54 TP53 ESR1
9 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.52 TP53 ESR1
10 intracellular steroid hormone receptor signaling pathway GO:0030518 9.51 PGR ESR1
11 cellular response to estradiol stimulus GO:0071392 9.5 MYOG MYOD1 ESR1
12 positive regulation of skeletal muscle fiber development GO:0048743 9.49 MYOG MYOD1
13 paracrine signaling GO:0038001 9.48 PGR CD34
14 positive regulation of helicase activity GO:0051096 9.46 MSH6 MSH2
15 muscle cell fate commitment GO:0042693 9.43 MYOG MYOD1
16 mismatch repair GO:0006298 9.43 PMS2 MSH6 MSH2
17 maintenance of DNA repeat elements GO:0043570 9.4 MSH6 MSH2
18 somatic recombination of immunoglobulin gene segments GO:0016447 9.37 MSH6 MSH2
19 determination of adult lifespan GO:0008340 9.13 TP53 MSH6 MSH2
20 somatic hypermutation of immunoglobulin genes GO:0016446 8.8 PMS2 MSH6 MSH2

Molecular functions related to Cervical Adenosarcoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.43 TP53 SUZ12 PMS2 PGR MYOG MYOD1
2 DNA binding GO:0003677 9.97 TP53 PMS2 PGR MYOG MYOD1 MSH6
3 DNA-binding transcription factor activity GO:0003700 9.93 TP53 PGR MYOG MYOD1 ESR1
4 transcription factor binding GO:0008134 9.85 TP53 MYOD1 ESR1 CD34
5 chromatin binding GO:0003682 9.83 TP53 MYOD1 MSH6 MSH2 ESR1
6 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.8 TP53 PGR MYOG MYOD1 ESR1
7 proximal promoter sequence-specific DNA binding GO:0000987 9.69 TP53 MYOG MYOD1
8 chromatin DNA binding GO:0031490 9.67 SUZ12 MYOG MYOD1
9 RNA polymerase II transcription corepressor binding GO:0001226 9.57 SUZ12 ESR1
10 four-way junction DNA binding GO:0000400 9.56 MSH6 MSH2
11 MutLalpha complex binding GO:0032405 9.48 MSH6 MSH2
12 oxidized purine DNA binding GO:0032357 9.46 MSH6 MSH2
13 enzyme binding GO:0019899 9.43 TP53 PGR MYOD1 MSH6 MSH2 ESR1
14 guanine/thymine mispair binding GO:0032137 9.37 MSH6 MSH2
15 single guanine insertion binding GO:0032142 9.26 MSH6 MSH2
16 single thymine insertion binding GO:0032143 9.16 MSH6 MSH2
17 mismatched DNA binding GO:0030983 8.8 PMS2 MSH6 MSH2

Sources for Cervical Adenosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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