MCID: CRV033
MIFTS: 30

Cervical Adenosquamous Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervical Adenosquamous Carcinoma

MalaCards integrated aliases for Cervical Adenosquamous Carcinoma:

Name: Cervical Adenosquamous Carcinoma 12 15 17 71
Adenosquamous Cell Carcinoma of the Cervix Uteri 12
Adenosquamous Carcinoma of Cervix 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5636
NCIt 49 C4519
UMLS 71 C0346202

Summaries for Cervical Adenosquamous Carcinoma

Disease Ontology : 12 A cervical carcinoma that derives from squamous cells and gland-like cells.

MalaCards based summary : Cervical Adenosquamous Carcinoma, also known as adenosquamous cell carcinoma of the cervix uteri, is related to adenosquamous carcinoma and glassy cell variant cervical adenosquamous carcinoma. An important gene associated with Cervical Adenosquamous Carcinoma is KDR (Kinase Insert Domain Receptor), and among its related pathways/superpathways are MAPK signaling pathway and Tyrosine Kinases / Adaptors. The drugs Epothilone B and Antimitotic Agents have been mentioned in the context of this disorder. Affiliated tissues include cervix, bone and salivary gland, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Cervical Adenosquamous Carcinoma

Diseases related to Cervical Adenosquamous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 adenosquamous carcinoma 30.1 MAML2 EGFR CRTC1
2 glassy cell variant cervical adenosquamous carcinoma 12.7
3 pulmonary vein stenosis 10.4 PDGFRA KDR
4 fibrosarcoma of bone 10.3 PDGFRA KDR
5 papillary squamous carcinoma 10.3 MAPK8IP1 EGFR
6 adenocarcinoma 10.2
7 gastroesophageal junction adenocarcinoma 10.2 KDR EGFR
8 mixed glioma 10.2 PDGFRA EGFR
9 bone squamous cell carcinoma 10.2 KDR EGFR
10 suppressor of tumorigenicity 3 10.2
11 cervix carcinoma 10.2
12 cervical adenocarcinoma 10.2
13 gastroesophageal adenocarcinoma 10.1 KDR EGFR
14 fibrillary astrocytoma 10.1 PDGFRA EGFR
15 gliosarcoma 10.1 PDGFRA KDR EGFR
16 placenta accreta 10.1 KDR EGFR
17 small cell carcinoma 10.0
18 47,xyy 10.0
19 lymphangioma 10.0 KDR EGFR
20 glioma susceptibility 1 10.0 PDGFRA KDR EGFR
21 keratinizing squamous cell carcinoma 9.9 MAML2 EGFR
22 benign ependymoma 9.8 PDGFRA EGFR
23 lacrimal gland mucoepidermoid carcinoma 9.7 MAML2 CRTC1
24 cutaneous mucoepidermoid carcinoma 9.7 MAML2 CRTC1
25 schneiderian carcinoma 9.7 MAML2 CRTC1
26 lung adenoid cystic carcinoma 9.7 MAML2 CRTC1
27 breast mucoepidermoid carcinoma 9.7 MAML2 CRTC1
28 bile duct mucoepidermoid carcinoma 9.7 MAML2 CRTC1
29 clear cell hidradenoma 9.7 MAML2 CRTC1
30 hidradenoma 9.7 MAML2 CRTC1
31 pleomorphic adenoma carcinoma 9.7 MAML2 CRTC1
32 warthin tumor 9.6 MAML2 CRTC1
33 endobronchial lipoma 9.6 MAML2 CRTC1
34 pancreatic adenosquamous carcinoma 9.6 MAML2 CRTC1
35 sweat gland neoplasm 9.5 MAML2 CRTC1
36 breast metaplastic carcinoma 9.5 MAML2 EGFR CRTC1
37 mucoepidermoid carcinoma 9.5 MAML2 EGFR CRTC1
38 tonsil cancer 9.5 MAML2 EGFR CRTC1
39 oropharynx cancer 9.5 MAML2 EGFR CRTC1
40 salivary gland disease 9.5 MAML2 EGFR CRTC1
41 salivary gland carcinoma 9.4 MAML2 EGFR CRTC1
42 oral cavity cancer 9.3 MAML2 EGFR CRTC1

Graphical network of the top 20 diseases related to Cervical Adenosquamous Carcinoma:



Diseases related to Cervical Adenosquamous Carcinoma

Symptoms & Phenotypes for Cervical Adenosquamous Carcinoma

GenomeRNAi Phenotypes related to Cervical Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.6 EGFR
2 Decreased viability GR00173-A 9.6 MAPK8IP1 PDGFRA
3 Decreased viability GR00221-A-1 9.6 EGFR KDR PDGFRA
4 Decreased viability GR00221-A-2 9.6 KDR
5 Decreased viability GR00221-A-3 9.6 KDR PDGFRA
6 Decreased viability GR00221-A-4 9.6 EGFR KDR MAPK8IP1 PDGFRA
7 Decreased viability GR00301-A 9.6 MAPK8IP1
8 Decreased viability GR00342-S-3 9.6 MAPK8IP1
9 Decreased viability GR00402-S-2 9.6 EGFR KDR MAPK8IP1 PDGFRA

Drugs & Therapeutics for Cervical Adenosquamous Carcinoma

Drugs for Cervical Adenosquamous Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Epothilone B Phase 2
2 Antimitotic Agents Phase 2
3 Epothilones Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Clinical Trial of Ixabepilone (Ixempra [R], BMS-247550, NSC 710428), an Epothilone B Analog, in Cervical Cancer Terminated NCT00924066 Phase 2 Ixempra (Ixabepilone (BMS-247550) )

Search NIH Clinical Center for Cervical Adenosquamous Carcinoma

Genetic Tests for Cervical Adenosquamous Carcinoma

Anatomical Context for Cervical Adenosquamous Carcinoma

MalaCards organs/tissues related to Cervical Adenosquamous Carcinoma:

40
Cervix, Bone, Salivary Gland, Breast, Testes, Ovary, Lung

Publications for Cervical Adenosquamous Carcinoma

Articles related to Cervical Adenosquamous Carcinoma:

(show all 27)
# Title Authors PMID Year
1
Cervical adenosquamous carcinoma: detailed analysis of morphology, immunohistochemical profile, and clinical outcomes in 59 cases. 61
30258209 2019
2
Leptomeningeal metastasis of poorly differentiated uterine cervical adenosquamous carcinoma following reirradiation to metastatic vertebrae: A case report. 61
28489796 2017
3
A case of melanocytic cervical adenosquamous carcinoma complicated with Cushing's syndrome. 61
29767880 2017
4
Cervical adenosquamous carcinoma with extension to uterine corpus. 61
27306573 2016
5
Prevalence, distribution, and viral burden of all 15 high-risk human papillomavirus types in adenosquamous carcinoma of the uterine cervix: a multiplex real-time polymerase chain reaction-based study. 61
24355194 2014
6
Cervical screening test results associated with 265 histopathologic diagnoses of cervical glandular neoplasia. 61
23765533 2013
7
Outcome analysis of cervical adenosquamous carcinoma compared with adenocarcinoma. 61
22497449 2012
8
Duodenal metastasis of cervical adenosquamous carcinoma. 61
22387251 2012
9
Ovarian metastasis in a transposed ovary 10 years after primary cervical cancer: the importance of histologic examination and review of literature. 61
22692488 2011
10
Cutaneous metastases of cervical adenosquamous carcinoma. 61
20633787 2010
11
Clinical utility of adjunctive high-risk human papillomavirus DNA testing in women with Papanicolaou test findings of atypical glandular cells. 61
20073612 2010
12
[Clinical analysis of 132 cases of cervical adenosquamous carcinoma and cervical adenocarcinoma]. 61
20038304 2010
13
Prevalence, viral load, and physical status of HPV 16 and 18 in cervical adenosquamous carcinoma. 61
19727809 2009
14
Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma. 61
19563658 2009
15
Mucoepidermoid carcinoma of the cervix: another tumor with the t(11;19)-associated CRTC1-MAML2 gene fusion. 61
19092631 2009
16
[Prognosis analysis of 83 cases of cervical adenosquamous carcinoma]. 61
18799035 2008
17
[Clinical analysis of 21 cases of cervical adenosquamous carcinoma]. 61
18683752 2008
18
Cervical adenosquamous carcinoma: tumor implantation in an episiotomy scar. 61
17666630 2007
19
Cyclooxygenase-2 and epidermal growth factor receptor expressions in different histological subtypes of cervical carcinomas. 61
17581404 2007
20
Evaluation of p16INK4a in cervical lesion of premenopausal and postmenopausal women. 61
17600938 2007
21
Metastasis detection with 18 FDG-positron emission tomography/computed tomography in gestational trophoblastic neoplasia: a report of 2 cases. 61
17165437 2006
22
Unusual recurrence of cervical adenosquamous carcinoma after conservative surgery. 61
10684719 2000
23
Port-site metastasis following laparoscopic lymphadenectomy for adenosquamous carcinoma of the cervix. 61
10385565 1999
24
HPV in situ hybridization with catalyzed signal amplification and polymerase chain reaction in establishing cerebellar metastasis of a cervical carcinoma. 61
10333232 1999
25
[Immunohistochemical study of cytokeratin and vimentin expression in mixed type of adenocarcinoma and squamous cell carcinoma]. 61
8921518 1996
26
Clear cell adenosquamous carcinoma of the cervix. An aggressive tumor associated with human papillomavirus-18. 61
8635063 1995
27
In situ hybridization for human papillomavirus DNA in uterine adenosquamous carcinoma with glassy cell features ("glassy cell carcinoma"). 61
1324599 1992

Variations for Cervical Adenosquamous Carcinoma

Expression for Cervical Adenosquamous Carcinoma

Search GEO for disease gene expression data for Cervical Adenosquamous Carcinoma.

Pathways for Cervical Adenosquamous Carcinoma

Pathways related to Cervical Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.12 PDGFRA MAPK8IP1 KDR EGFR
2 11.3 PDGFRA KDR EGFR
3
Show member pathways
10.85 PDGFRA KDR
4 10.64 PDGFRA KDR
5 10.43 PDGFRA KDR EGFR

GO Terms for Cervical Adenosquamous Carcinoma

Cellular components related to Cervical Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.32 ZNF592 ZNF473 POGK PDGFRA MAPK8IP1 MAML2
2 receptor complex GO:0043235 9.13 PDGFRA KDR EGFR

Biological processes related to Cervical Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.54 PDGFRA KDR EGFR
2 protein autophosphorylation GO:0046777 9.43 PDGFRA KDR EGFR
3 cellular response to reactive oxygen species GO:0034614 9.4 PDGFRA EGFR
4 peptidyl-tyrosine autophosphorylation GO:0038083 9.32 KDR EGFR
5 regulation of JNK cascade GO:0046328 9.16 MAPK8IP1 EGFR
6 peptidyl-tyrosine phosphorylation GO:0018108 9.13 PDGFRA KDR EGFR
7 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 8.8 PDGFRA KDR EGFR

Molecular functions related to Cervical Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.43 PDGFRA KDR EGFR
2 vascular endothelial growth factor binding GO:0038085 9.16 PDGFRA KDR
3 vascular endothelial growth factor-activated receptor activity GO:0005021 8.96 PDGFRA KDR
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.8 PDGFRA KDR EGFR

Sources for Cervical Adenosquamous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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