MCID: CRV033
MIFTS: 28

Cervical Adenosquamous Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervical Adenosquamous Carcinoma

MalaCards integrated aliases for Cervical Adenosquamous Carcinoma:

Name: Cervical Adenosquamous Carcinoma 12 15 17 71
Adenosquamous Cell Carcinoma of the Cervix Uteri 12
Adenosquamous Carcinoma of Cervix 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5636
NCIt 50 C4519
SNOMED-CT 67 254888007
UMLS 71 C0346202

Summaries for Cervical Adenosquamous Carcinoma

Disease Ontology : 12 A cervical carcinoma that derives from squamous cells and gland-like cells.

MalaCards based summary : Cervical Adenosquamous Carcinoma, also known as adenosquamous cell carcinoma of the cervix uteri, is related to adenosquamous carcinoma and glassy cell variant cervical adenosquamous carcinoma. An important gene associated with Cervical Adenosquamous Carcinoma is KDR (Kinase Insert Domain Receptor), and among its related pathways/superpathways are Calcium signaling pathway and Tyrosine Kinases / Adaptors. Affiliated tissues include cervix and ovary.

Related Diseases for Cervical Adenosquamous Carcinoma

Diseases related to Cervical Adenosquamous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 adenosquamous carcinoma 30.8 PDGFRA MAML2 EGFR CRTC1
2 glassy cell variant cervical adenosquamous carcinoma 11.6
3 pulmonary vein stenosis 10.2 PDGFRA KDR
4 adenocarcinoma 10.2
5 lacrimal gland mucoepidermoid carcinoma 10.2 MAML2 CRTC1
6 warthin tumor 10.2 MAML2 CRTC1
7 schneiderian carcinoma 10.2 MAML2 CRTC1
8 cutaneous mucoepidermoid carcinoma 10.2 MAML2 CRTC1
9 breast mucoepidermoid carcinoma 10.2 MAML2 CRTC1
10 lung adenoid cystic carcinoma 10.2 MAML2 CRTC1
11 breast metaplastic carcinoma 10.2 MAML2 EGFR
12 bile duct mucoepidermoid carcinoma 10.2 MAML2 CRTC1
13 clear cell hidradenoma 10.2 MAML2 CRTC1
14 mixed glioma 10.2 PDGFRA EGFR
15 hidradenoma 10.2 MAML2 CRTC1
16 pleomorphic adenoma carcinoma 10.2 MAML2 CRTC1
17 bone squamous cell carcinoma 10.2 KDR EGFR
18 keratinizing squamous cell carcinoma 10.1 MAML2 EGFR
19 suppressor of tumorigenicity 3 10.1
20 cervix carcinoma 10.1
21 cervical adenocarcinoma 10.1
22 endobronchial lipoma 10.1 MAML2 CRTC1
23 lung non-squamous non-small cell carcinoma 10.1 KDR EGFR
24 gastroesophageal junction adenocarcinoma 10.1 KDR EGFR
25 hemangioblastoma 10.1 PDGFRA KDR EGFR
26 supraglottis cancer 10.1 VHLL EGFR
27 mucoepidermoid carcinoma 10.1 MAML2 EGFR CRTC1
28 tonsil cancer 10.0 MAML2 EGFR CRTC1
29 oropharynx cancer 10.0 MAML2 EGFR CRTC1
30 salivary gland disease 10.0 MAML2 EGFR CRTC1
31 sweat gland benign neoplasm 10.0 MAML2 CRTC1
32 gliosarcoma 10.0 PDGFRA KDR EGFR
33 fibrosarcoma of bone 10.0 PDGFRA KDR
34 pancreatic adenosquamous carcinoma 10.0 MAML2 CRTC1
35 small cell carcinoma 10.0
36 in situ carcinoma 10.0
37 cervix uteri carcinoma in situ 10.0
38 47,xyy 10.0
39 cervical intraepithelial neoplasia 10.0
40 salivary gland carcinoma 10.0 MAML2 EGFR CRTC1
41 high grade glioma 10.0 PDGFRA KDR EGFR
42 large cell neuroendocrine carcinoma 9.9 PDGFRA EGFR

Graphical network of the top 20 diseases related to Cervical Adenosquamous Carcinoma:



Diseases related to Cervical Adenosquamous Carcinoma

Symptoms & Phenotypes for Cervical Adenosquamous Carcinoma

Drugs & Therapeutics for Cervical Adenosquamous Carcinoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Human Papilloma Virus (HPV) Circulating Tumor DNA (ctDNA) in Cervical Cancer Recruiting NCT04574635

Search NIH Clinical Center for Cervical Adenosquamous Carcinoma

Genetic Tests for Cervical Adenosquamous Carcinoma

Anatomical Context for Cervical Adenosquamous Carcinoma

MalaCards organs/tissues related to Cervical Adenosquamous Carcinoma:

40
Cervix, Ovary

Publications for Cervical Adenosquamous Carcinoma

Articles related to Cervical Adenosquamous Carcinoma:

(show all 29)
# Title Authors PMID Year
1
Analysis of clinical characteristics and prognosis with cervical adenosquamous carcinoma: a large population-based study. 61
33478265 2021
2
A Novel Ciliated, Mucin-producing Variant of HPV-related Cervical Adenosquamous Carcinoma In Situ: A Case Report. 61
32947332 2020
3
Cervical adenosquamous carcinoma: detailed analysis of morphology, immunohistochemical profile, and clinical outcomes in 59 cases. 61
30258209 2019
4
Leptomeningeal metastasis of poorly differentiated uterine cervical adenosquamous carcinoma following reirradiation to metastatic vertebrae: A case report. 61
28489796 2017
5
A case of melanocytic cervical adenosquamous carcinoma complicated with Cushing's syndrome. 61
29767880 2017
6
Cervical adenosquamous carcinoma with extension to uterine corpus. 61
27306573 2016
7
Prevalence, distribution, and viral burden of all 15 high-risk human papillomavirus types in adenosquamous carcinoma of the uterine cervix: a multiplex real-time polymerase chain reaction-based study. 61
24355194 2014
8
Cervical screening test results associated with 265 histopathologic diagnoses of cervical glandular neoplasia. 61
23765533 2013
9
Outcome analysis of cervical adenosquamous carcinoma compared with adenocarcinoma. 61
22497449 2012
10
Duodenal metastasis of cervical adenosquamous carcinoma. 61
22387251 2012
11
Ovarian metastasis in a transposed ovary 10 years after primary cervical cancer: the importance of histologic examination and review of literature. 61
22692488 2011
12
Cutaneous metastases of cervical adenosquamous carcinoma. 61
20633787 2010
13
Clinical utility of adjunctive high-risk human papillomavirus DNA testing in women with Papanicolaou test findings of atypical glandular cells. 61
20073612 2010
14
[Clinical analysis of 132 cases of cervical adenosquamous carcinoma and cervical adenocarcinoma]. 61
20038304 2010
15
Prevalence, viral load, and physical status of HPV 16 and 18 in cervical adenosquamous carcinoma. 61
19727809 2009
16
Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma. 61
19563658 2009
17
Mucoepidermoid carcinoma of the cervix: another tumor with the t(11;19)-associated CRTC1-MAML2 gene fusion. 61
19092631 2009
18
[Prognosis analysis of 83 cases of cervical adenosquamous carcinoma]. 61
18799035 2008
19
[Clinical analysis of 21 cases of cervical adenosquamous carcinoma]. 61
18683752 2008
20
Cervical adenosquamous carcinoma: tumor implantation in an episiotomy scar. 61
17666630 2007
21
Cyclooxygenase-2 and epidermal growth factor receptor expressions in different histological subtypes of cervical carcinomas. 61
17581404 2007
22
Evaluation of p16INK4a in cervical lesion of premenopausal and postmenopausal women. 61
17600938 2007
23
Metastasis detection with 18 FDG-positron emission tomography/computed tomography in gestational trophoblastic neoplasia: a report of 2 cases. 61
17165437 2006
24
Unusual recurrence of cervical adenosquamous carcinoma after conservative surgery. 61
10684719 2000
25
Port-site metastasis following laparoscopic lymphadenectomy for adenosquamous carcinoma of the cervix. 61
10385565 1999
26
HPV in situ hybridization with catalyzed signal amplification and polymerase chain reaction in establishing cerebellar metastasis of a cervical carcinoma. 61
10333232 1999
27
[Immunohistochemical study of cytokeratin and vimentin expression in mixed type of adenocarcinoma and squamous cell carcinoma]. 61
8921518 1996
28
Clear cell adenosquamous carcinoma of the cervix. An aggressive tumor associated with human papillomavirus-18. 61
8635063 1995
29
In situ hybridization for human papillomavirus DNA in uterine adenosquamous carcinoma with glassy cell features ("glassy cell carcinoma"). 61
1324599 1992

Variations for Cervical Adenosquamous Carcinoma

Expression for Cervical Adenosquamous Carcinoma

Search GEO for disease gene expression data for Cervical Adenosquamous Carcinoma.

Pathways for Cervical Adenosquamous Carcinoma

Pathways related to Cervical Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.88 PDGFRA KDR EGFR
2 11.3 PDGFRA KDR EGFR
3
Show member pathways
10.99 KDR EGFR
4
Show member pathways
10.79 PDGFRA KDR
5 10.54 PDGFRA KDR
6 10.43 PDGFRA KDR EGFR

GO Terms for Cervical Adenosquamous Carcinoma

Cellular components related to Cervical Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.8 PDGFRA KDR EGFR

Biological processes related to Cervical Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.72 UTP25 POGK PDGFRA KDR EGFR
2 viral process GO:0016032 9.67 PDGFRA KDR EGFR CRTC1
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.61 PDGFRA KDR EGFR
4 cellular response to reactive oxygen species GO:0034614 9.46 PDGFRA EGFR
5 protein autophosphorylation GO:0046777 9.43 PDGFRA KDR EGFR
6 peptidyl-tyrosine autophosphorylation GO:0038083 9.4 KDR EGFR
7 peptidyl-tyrosine phosphorylation GO:0018108 9.33 PDGFRA KDR EGFR
8 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.13 PDGFRA KDR EGFR
9 positive regulation of kinase activity GO:0033674 8.8 PDGFRA KDR EGFR

Molecular functions related to Cervical Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.43 PDGFRA KDR EGFR
2 vascular endothelial growth factor-activated receptor activity GO:0005021 9.16 PDGFRA KDR
3 vascular endothelial growth factor binding GO:0038085 8.96 PDGFRA KDR
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.8 PDGFRA KDR EGFR

Sources for Cervical Adenosquamous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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