MCID: CRV036
MIFTS: 42

Cervical Carcinosarcoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervical Carcinosarcoma

MalaCards integrated aliases for Cervical Carcinosarcoma:

Name: Cervical Carcinosarcoma 12 15 74
Cervical Malignant Mixed Mesodermal Mullerian Tumor 12
Cervical Mixed Epithelial and Mesenchymal Neoplasm 12
Cervical Malignant Mixed Mullerian Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4112

Summaries for Cervical Carcinosarcoma

Disease Ontology : 12 A cervical cancer that has material basis in carcinomatous (epithelial tissue) and sarcomatous (connective tissue) components.

MalaCards based summary : Cervical Carcinosarcoma, also known as cervical malignant mixed mesodermal mullerian tumor, is related to cervical adenosarcoma and carcinosarcoma. An important gene associated with Cervical Carcinosarcoma is BCL2 (BCL2 Apoptosis Regulator), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. The drugs Paclitaxel and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include breast, cervix and b cells, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Related Diseases for Cervical Carcinosarcoma

Diseases related to Cervical Carcinosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 cervical adenosarcoma 31.5 GP5 GP6 PGR
2 carcinosarcoma 30.3 MME PGR TP53
3 endometrial cancer 28.9 BCL2 ESR1 MME PGR TP53
4 carcinosarcoma of the cervix uteri 11.8
5 cervical wilms' tumor 11.3
6 intravascular large b-cell lymphoma 10.3 BCL2 MME
7 endocervical carcinoma 10.3 ESR1 MAPK8IP1
8 fallopian tube adenocarcinoma 10.3 MAPK8IP1 MME
9 vulvar intraepithelial neoplasia 10.3 BIRC5 TP53
10 breast myofibroblastoma 10.3 ESR1 MME
11 bladder transitional cell papilloma 10.3 BIRC5 TP53
12 malignant teratoma 10.2 BCL2 TP53
13 intravenous leiomyomatosis 10.2 ESR1 MME
14 testicular torsion 10.2 BCL2 TP53
15 suppressor of tumorigenicity 3 10.2 BCL2 TP53
16 benign metastasizing leiomyoma 10.2 BCL2 PGR
17 soft tissue sarcoma 10.2 BCL2 TP53
18 gastric lymphoma 10.2 BCL2 TP53
19 sarcomatoid squamous cell skin carcinoma 10.2 MAPK8IP1 MME
20 anogenital venereal wart 10.2 GP6 TP53
21 vestibular gland benign neoplasm 10.2 ESR1 PGR
22 bartholin's gland adenoma 10.2 ESR1 PGR
23 vulvar syringoma 10.2 ESR1 PGR
24 lung leiomyoma 10.2 ESR1 PGR
25 glassy cell carcinoma of the cervix 10.2 ESR1 PGR
26 focal cortical dysplasia, type ii 10.2 BCL2 TP53
27 vulvar benign neoplasm 10.2 ESR1 PGR
28 trigonitis 10.2 ESR1 PGR
29 vulvar leiomyoma 10.2 ESR1 PGR
30 predominantly cortical thymoma 10.2 ESR1 PGR
31 breast medullary carcinoma 10.2 ESR1 PGR
32 breast scirrhous carcinoma 10.2 ESR1 PGR
33 bartholin's gland benign neoplasm 10.1 ESR1 PGR
34 oncocytic breast carcinoma 10.1 ESR1 PGR
35 progesterone-receptor positive breast cancer 10.1 ESR1 PGR
36 progesterone resistance 10.1 ESR1 PGR
37 penile disease 10.1 GP6 TP53
38 endometrial squamous cell carcinoma 10.1 ESR1 PGR
39 cribriform carcinoma 10.1 ESR1 PGR
40 endometrial mucinous adenocarcinoma 10.1 ESR1 PGR
41 adenoid basal cell carcinoma 10.1 ESR1 PGR
42 apocrine adenocarcinoma 10.1 ESR1 PGR
43 cll/sll 10.1 MME TP53
44 peritoneal benign neoplasm 10.1 ESR1 PGR
45 benign meningioma 10.1 BIRC5 PGR
46 gender identity disorder 10.1 ESR1 PGR
47 deep angioma 10.1 ESR1 PGR
48 diffuse peritoneal leiomyomatosis 10.1 ESR1 PGR
49 breast adenoid cystic carcinoma 10.1 ESR1 PGR
50 myxoid leiomyosarcoma 10.1 MME PGR

Graphical network of the top 20 diseases related to Cervical Carcinosarcoma:



Diseases related to Cervical Carcinosarcoma

Symptoms & Phenotypes for Cervical Carcinosarcoma

MGI Mouse Phenotypes related to Cervical Carcinosarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.02 BCL2 BIRC5 ESR1 GP5 GP6 MAPK8IP1
2 endocrine/exocrine gland MP:0005379 9.91 BCL2 BIRC5 ESR1 MAPK8IP1 MAPK8IP2 PGR
3 immune system MP:0005387 9.8 BCL2 BIRC5 ESR1 GP6 MME PGR
4 integument MP:0010771 9.63 BCL2 ESR1 GP6 MME PGR TP53
5 mortality/aging MP:0010768 9.56 BCL2 BIRC5 ESR1 GP6 MAPK8IP1 MAPK8IP2
6 reproductive system MP:0005389 9.17 BCL2 ESR1 GP6 MAPK8IP1 MAPK8IP2 PGR

Drugs & Therapeutics for Cervical Carcinosarcoma

Drugs for Cervical Carcinosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
2
Bevacizumab Approved, Investigational Phase 1 216974-75-3
3 Antineoplastic Agents, Phytogenic Phase 1
4 Angiogenesis Modulating Agents Phase 1
5 Antibodies Phase 1
6 Immunoglobulin G Phase 1
7 Antibodies, Monoclonal Phase 1
8 Albumin-Bound Paclitaxel Phase 1
9 Antineoplastic Agents, Immunological Phase 1
10 Antimitotic Agents Phase 1
11 Endothelial Growth Factors Phase 1
12 Immunologic Factors Phase 1
13 Angiogenesis Inhibitors Phase 1
14 Mitogens Phase 1
15 Immunoglobulins Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery or Gynecological Cancers Suspended NCT02020707 Phase 1 Paclitaxel Albumin-Stabilized Nanoparticle Formulation

Search NIH Clinical Center for Cervical Carcinosarcoma

Genetic Tests for Cervical Carcinosarcoma

Anatomical Context for Cervical Carcinosarcoma

MalaCards organs/tissues related to Cervical Carcinosarcoma:

42
Breast, Cervix, B Cells, Ovary, Endothelial, Bone, Smooth Muscle

Publications for Cervical Carcinosarcoma

Articles related to Cervical Carcinosarcoma:

# Title Authors Year
1
Therapy Modalities, Prognostic Factors, and Outcome of the Primary Cervical Carcinosarcoma: Meta-analysis of Extremely Rare Tumor of Cervix. ( 28708788 )
2017
2
Coexistence of homologous-type cervical carcinosarcoma with endometrioid-type G1 endometrial cancer: a case report with an immunohistochemical study. ( 25400816 )
2014
3
Mesonephric adenocarcinoma with a sarcomatous component, a notable subtype of cervical carcinosarcoma: a case report and review of the literature. ( 23651629 )
2013
4
High expressions of bcl-2 and survivin, and decreased apoptosis in uterine cervical carcinosarcoma compared to cervical squamous cell carcinoma. ( 20668868 )
2011
5
A case of uterine cervical carcinosarcoma recurrence who obtained a clinically complete response by ifosfamide, doxorubicin and cisplatin. ( 21446343 )
2011
6
Uterine cervical carcinosarcoma with heterologous mesenchymal component: a case report and review of the literature. ( 19263060 )
2009
7
Cervical carcinosarcoma: a case report. ( 18357808 )
2008
8
Case of uterine cervical carcinosarcoma. ( 16176508 )
2005
9
Cervical carcinosarcoma occurring after subtotal hysterectomy, a case report. ( 9441782 )
1997
10
Cervical carcinosarcoma: a case report. ( 3957124 )
1986

Variations for Cervical Carcinosarcoma

Expression for Cervical Carcinosarcoma

Search GEO for disease gene expression data for Cervical Carcinosarcoma.

Pathways for Cervical Carcinosarcoma

GO Terms for Cervical Carcinosarcoma

Cellular components related to Cervical Carcinosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 8.92 BCL2 ESR1 MAPK8IP2 TP53

Biological processes related to Cervical Carcinosarcoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.76 BCL2 BIRC5 MAPK8IP1 TP53
2 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.52 BCL2 TP53
3 behavioral fear response GO:0001662 9.51 BCL2 MAPK8IP2
4 response to gamma radiation GO:0010332 9.49 BCL2 TP53
5 cell aging GO:0007569 9.48 BCL2 TP53
6 negative regulation of apoptotic signaling pathway GO:2001234 9.43 BCL2 MAPK8IP2
7 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.4 BCL2 TP53
8 negative regulation of intrinsic apoptotic signaling pathway GO:2001243 9.37 BCL2 MAPK8IP1
9 regulation of JNK cascade GO:0046328 9.32 MAPK8IP1 MAPK8IP2
10 replicative senescence GO:0090399 9.26 MME TP53
11 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.16 ESR1 TP53
12 regulation of mitochondrial membrane permeability GO:0046902 8.96 BCL2 TP53
13 regulation of apoptotic process GO:0042981 8.92 BCL2 BIRC5 ESR1 TP53

Molecular functions related to Cervical Carcinosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.65 BCL2 BIRC5 ESR1 PGR TP53
2 protein kinase binding GO:0019901 9.46 ESR1 MAPK8IP1 MAPK8IP2 TP53
3 protein phosphatase 2A binding GO:0051721 9.4 BCL2 TP53
4 steroid binding GO:0005496 9.37 ESR1 PGR
5 enzyme binding GO:0019899 9.26 BIRC5 ESR1 PGR TP53
6 MAP-kinase scaffold activity GO:0005078 8.62 MAPK8IP1 MAPK8IP2
7 protein binding GO:0005515 10.02 BCL2 BIRC5 ESR1 GP5 GP6 MAPK8IP1

Sources for Cervical Carcinosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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