MCID: CRV036
MIFTS: 32

Cervical Carcinosarcoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervical Carcinosarcoma

MalaCards integrated aliases for Cervical Carcinosarcoma:

Name: Cervical Carcinosarcoma 12 15 72
Cervical Malignant Mixed Mesodermal Mullerian Tumor 12
Cervical Mixed Epithelial and Mesenchymal Neoplasm 12
Cervical Malignant Mixed Mullerian Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4112
UMLS 72 C1332917 C1516420 C1518168

Summaries for Cervical Carcinosarcoma

Disease Ontology : 12 A cervical cancer that has material basis in carcinomatous (epithelial tissue) and sarcomatous (connective tissue) components.

MalaCards based summary : Cervical Carcinosarcoma, also known as cervical malignant mixed mesodermal mullerian tumor, is related to cervical adenosarcoma and carcinosarcoma. An important gene associated with Cervical Carcinosarcoma is BCL2 (BCL2 Apoptosis Regulator), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. Affiliated tissues include cervix, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Related Diseases for Cervical Carcinosarcoma

Diseases related to Cervical Carcinosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 cervical adenosarcoma 31.4 PGR GP6 GP5
2 carcinosarcoma 30.2 TP53 PGR MME
3 endometrial cancer 28.4 TP53 PGR MME ESR1 BCL2
4 carcinosarcoma of the cervix uteri 11.9
5 cervical wilms' tumor 11.4
6 intravascular large b-cell lymphoma 10.5 MME BCL2
7 endocervical carcinoma 10.5 MAPK8IP1 ESR1
8 fallopian tube adenocarcinoma 10.4 MME MAPK8IP1
9 vulvar intraepithelial neoplasia 10.4 TP53 BIRC5
10 bladder transitional cell papilloma 10.4 TP53 BIRC5
11 breast myofibroblastoma 10.4 MME ESR1
12 malignant teratoma 10.4 TP53 BCL2
13 intravenous leiomyomatosis 10.4 MME ESR1
14 testicular torsion 10.4 TP53 BCL2
15 suppressor of tumorigenicity 3 10.3 TP53 BCL2
16 soft tissue sarcoma 10.3 TP53 BCL2
17 benign metastasizing leiomyoma 10.3 PGR BCL2
18 anogenital venereal wart 10.3 TP53 GP6
19 sarcomatoid squamous cell skin carcinoma 10.3 MME MAPK8IP1
20 gastric lymphoma 10.3 TP53 BCL2
21 bartholin's gland adenoma 10.3 PGR ESR1
22 vestibular gland benign neoplasm 10.3 PGR ESR1
23 lung leiomyoma 10.3 PGR ESR1
24 vulvar syringoma 10.3 PGR ESR1
25 glassy cell carcinoma of the cervix 10.3 PGR ESR1
26 vulvar leiomyoma 10.2 PGR ESR1
27 trigonitis 10.2 PGR ESR1
28 vulvar benign neoplasm 10.2 PGR ESR1
29 predominantly cortical thymoma 10.2 PGR ESR1
30 breast scirrhous carcinoma 10.2 PGR ESR1
31 breast medullary carcinoma 10.2 PGR ESR1
32 oncocytic breast carcinoma 10.2 PGR ESR1
33 focal cortical dysplasia, type ii 10.2 TP53 BCL2
34 bartholin's gland benign neoplasm 10.2 PGR ESR1
35 progesterone-receptor positive breast cancer 10.2 PGR ESR1
36 penile disease 10.2 TP53 GP6
37 cribriform carcinoma 10.2 PGR ESR1
38 cll/sll 10.2 TP53 MME
39 endometrial squamous cell carcinoma 10.2 PGR ESR1
40 progesterone resistance 10.2 PGR ESR1
41 apocrine adenocarcinoma 10.2 PGR ESR1
42 adenoid basal cell carcinoma 10.2 PGR ESR1
43 endometrial mucinous adenocarcinoma 10.2 PGR ESR1
44 benign meningioma 10.2 PGR BIRC5
45 radiation cystitis 10.2 MAPK8IP2 MAPK8IP1
46 diffuse peritoneal leiomyomatosis 10.2 PGR ESR1
47 deep angioma 10.2 PGR ESR1
48 gender identity disorder 10.2 PGR ESR1
49 peritoneal benign neoplasm 10.2 PGR ESR1
50 breast adenoid cystic carcinoma 10.2 PGR ESR1

Graphical network of the top 20 diseases related to Cervical Carcinosarcoma:



Diseases related to Cervical Carcinosarcoma

Symptoms & Phenotypes for Cervical Carcinosarcoma

MGI Mouse Phenotypes related to Cervical Carcinosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.02 BCL2 BIRC5 ESR1 GP5 GP6 MAPK8IP1
2 endocrine/exocrine gland MP:0005379 9.91 BCL2 BIRC5 ESR1 MAPK8IP1 MAPK8IP2 PGR
3 immune system MP:0005387 9.8 BCL2 BIRC5 ESR1 GP6 MME PGR
4 integument MP:0010771 9.63 BCL2 ESR1 GP6 MME PGR TP53
5 mortality/aging MP:0010768 9.56 BCL2 BIRC5 ESR1 GP6 MAPK8IP1 MAPK8IP2
6 reproductive system MP:0005389 9.17 BCL2 ESR1 GP6 MAPK8IP1 MAPK8IP2 PGR

Drugs & Therapeutics for Cervical Carcinosarcoma

Search Clinical Trials , NIH Clinical Center for Cervical Carcinosarcoma

Genetic Tests for Cervical Carcinosarcoma

Anatomical Context for Cervical Carcinosarcoma

MalaCards organs/tissues related to Cervical Carcinosarcoma:

41
Cervix

Publications for Cervical Carcinosarcoma

Articles related to Cervical Carcinosarcoma:

(show all 16)
# Title Authors PMID Year
1
Therapy Modalities, Prognostic Factors, and Outcome of the Primary Cervical Carcinosarcoma: Meta-analysis of Extremely Rare Tumor of Cervix. 38
28708788 2017
2
Synchronous carcinosarcoma of the uterine cervix with adenoid basal carcinoma and cervical intraepithelial neoplasia III: A case report and literature review. 38
28214205 2017
3
Carcinosarcoma of the uterine cervix arising from Müllerian ducts. 38
26023676 2015
4
[Carcinosarcomas in female genital tracts: general review]. 38
25091658 2014
5
Coexistence of homologous-type cervical carcinosarcoma with endometrioid-type G1 endometrial cancer: a case report with an immunohistochemical study. 38
25400816 2014
6
Mesonephric adenocarcinoma with a sarcomatous component, a notable subtype of cervical carcinosarcoma: a case report and review of the literature. 38
23651629 2013
7
Mesonephric carcinosarcoma of the uterine cervix: a case report. 38
24020142 2013
8
High expressions of bcl-2 and survivin, and decreased apoptosis in uterine cervical carcinosarcoma compared to cervical squamous cell carcinoma. 38
20668868 2011
9
A case of uterine cervical carcinosarcoma recurrence who obtained a clinically complete response by ifosfamide, doxorubicin and cisplatin. 38
21446343 2011
10
Uterine cervical carcinosarcoma with heterologous mesenchymal component: a case report and review of the literature. 38
19263060 2009
11
[Clinical analysis of 12 cases of uterine carcinosarcoma]. 38
18479602 2008
12
Cervical carcinosarcoma: a case report. 38
18357808 2008
13
Case of uterine cervical carcinosarcoma. 38
16176508 2005
14
Carcinosarcoma of the uterine cervix composed of an adenoid cystic carcinoma and an homologous stromal sarcoma. A case report. 38
10949398 2000
15
Cervical carcinosarcoma occurring after subtotal hysterectomy, a case report. 38
9441782 1997
16
Cervical carcinosarcoma: a case report. 38
3957124 1986

Variations for Cervical Carcinosarcoma

Expression for Cervical Carcinosarcoma

Search GEO for disease gene expression data for Cervical Carcinosarcoma.

Pathways for Cervical Carcinosarcoma

GO Terms for Cervical Carcinosarcoma

Cellular components related to Cervical Carcinosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 8.92 TP53 MAPK8IP2 ESR1 BCL2

Biological processes related to Cervical Carcinosarcoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.76 TP53 MAPK8IP1 BIRC5 BCL2
2 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.52 TP53 BCL2
3 behavioral fear response GO:0001662 9.51 MAPK8IP2 BCL2
4 response to gamma radiation GO:0010332 9.49 TP53 BCL2
5 cell aging GO:0007569 9.48 TP53 BCL2
6 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.43 TP53 BCL2
7 negative regulation of apoptotic signaling pathway GO:2001234 9.4 MAPK8IP2 BCL2
8 negative regulation of intrinsic apoptotic signaling pathway GO:2001243 9.37 MAPK8IP1 BCL2
9 regulation of JNK cascade GO:0046328 9.32 MAPK8IP2 MAPK8IP1
10 replicative senescence GO:0090399 9.26 TP53 MME
11 regulation of mitochondrial membrane permeability GO:0046902 9.16 TP53 BCL2
12 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 8.96 TP53 ESR1
13 regulation of apoptotic process GO:0042981 8.92 TP53 ESR1 BIRC5 BCL2

Molecular functions related to Cervical Carcinosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.65 TP53 PGR ESR1 BIRC5 BCL2
2 protein kinase binding GO:0019901 9.46 TP53 MAPK8IP2 MAPK8IP1 ESR1
3 steroid binding GO:0005496 9.4 PGR ESR1
4 protein phosphatase 2A binding GO:0051721 9.37 TP53 BCL2
5 enzyme binding GO:0019899 9.26 TP53 PGR ESR1 BIRC5
6 MAP-kinase scaffold activity GO:0005078 8.62 MAPK8IP2 MAPK8IP1
7 protein binding GO:0005515 10.02 TP53 PGR MME MAPK8IP2 MAPK8IP1 GP6

Sources for Cervical Carcinosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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