MCID: CRV026
MIFTS: 34

Cervical Clear Cell Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervical Clear Cell Adenocarcinoma

MalaCards integrated aliases for Cervical Clear Cell Adenocarcinoma:

Name: Cervical Clear Cell Adenocarcinoma 12 15 73
Clear Cell Carcinoma of the Cervix Uteri 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5303
NCIt 50 C6344
UMLS 73 C1332912

Summaries for Cervical Clear Cell Adenocarcinoma

Disease Ontology : 12 A cervical adenocarcinoma that derives from epithelial cells which have clear cytoplasm.

MalaCards based summary : Cervical Clear Cell Adenocarcinoma, also known as clear cell carcinoma of the cervix uteri, is related to diethylstilbestrol syndrome and brooke-spiegler syndrome. An important gene associated with Cervical Clear Cell Adenocarcinoma is KRT14 (Keratin 14), and among its related pathways/superpathways are Developmental Biology and Circadian entrainment. Affiliated tissues include cervix, lung and skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Cervical Clear Cell Adenocarcinoma

Diseases related to Cervical Clear Cell Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 239)
# Related Disease Score Top Affiliating Genes
1 diethylstilbestrol syndrome 11.3
2 brooke-spiegler syndrome 10.3 KRT14 KRT8
3 epidermolysis bullosa simplex, dowling-meara type 10.3 KRT14 KRT5
4 epidermolysis bullosa simplex with mottled pigmentation 10.3 KRT14 KRT5
5 cryptogenic cirrhosis 10.3 KRT18 KRT8
6 vesiculobullous skin disease 10.3 KRT14 KRT5
7 prostate squamous cell carcinoma 10.3 KRT5 KRT8
8 nasal cavity squamous cell carcinoma 10.3 KRT5 KRT8
9 sarcomatoid squamous cell skin carcinoma 10.3 KRT5 KRT8
10 dowling-degos disease 1 10.3 KITLG KRT5
11 lymphoepithelioma-like thymic carcinoma 10.3 KRT18 KRT5
12 microglandular adenosis 10.3 KRT18 PGR
13 neurenteric cyst 10.3 KRT18 KRT8
14 adenocarcinoma 10.2
15 clear cell adenocarcinoma 10.2
16 benign breast adenomyoepithelioma 10.2 KRT14 KRT5
17 seminal vesicle tumor 10.2 KRT18 SYP
18 lichen planopilaris 10.2 KRT14 KRT5
19 epidermolysis bullosa simplex, autosomal recessive 1 10.2 KRT14 KRT5
20 mammographic density 10.2 ESR1 PGR
21 retinitis pigmentosa 47 10.2 ESR1 PGR
22 retinitis pigmentosa 20 10.2 ESR1 PGR
23 hidradenocarcinoma 10.2 ESR1 KRT5
24 uterine benign neoplasm 10.2 ESR1 PGR
25 luminal breast carcinoma 10.2 ESR1 PGR
26 endometriosis of ovary 10.2 ESR1 PGR
27 limbal stem cell deficiency 10.2 KRT14 KRT19
28 estrogen excess 10.2 ESR1 PGR
29 female reproductive endometrioid cancer 10.2 ESR1 PGR
30 smooth muscle tumor 10.2 ESR1 PGR
31 intramuscular hemangioma 10.2 ESR1 PGR
32 polyposis, skin pigmentation, alopecia, and fingernail changes 10.2 KRT19 KRT8
33 inflammatory breast carcinoma 10.2 ESR1 PGR
34 embryoma 10.2 KRT14 KRT19
35 synchronous bilateral breast carcinoma 10.2 ESR1 PGR
36 uterine corpus cancer 10.2 ESR1 PGR
37 large cell acanthoma 10.2 KRT14 KRT5
38 perivascular epithelioid cell tumor 10.2 PGR SYP
39 anterior cranial fossa meningioma 10.2 PGR SYP
40 sclerosing hemangioma 10.2 PGR SYP
41 tuberculum sellae meningioma 10.2 PGR SYP
42 breast metaplastic carcinoma 10.2 KRT5 PGR
43 epidermolysis bullosa simplex, localized 10.2 KRT14 KRT5
44 vestibular gland benign neoplasm 10.2 ESR1 PGR
45 bartholin's gland adenoma 10.2 ESR1 PGR
46 epidural neoplasm 10.2 KRT19 KRT5
47 vulvar syringoma 10.2 ESR1 PGR
48 cloacogenic carcinoma 10.2 ENO2 KRT5
49 idiopathic corneal edema 10.2 KRT19 KRT8
50 glassy cell carcinoma of the cervix 10.2 ESR1 PGR

Graphical network of the top 20 diseases related to Cervical Clear Cell Adenocarcinoma:



Diseases related to Cervical Clear Cell Adenocarcinoma

Symptoms & Phenotypes for Cervical Clear Cell Adenocarcinoma

GenomeRNAi Phenotypes related to Cervical Clear Cell Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.47 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.47 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.47 KRT18 KRT5
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.47 KRT5 KRT8
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.47 KRT5
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.47 KRT18
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.47 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.47 KRT18 KRT5 KRT8
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.47 KRT18
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.47 KRT5

MGI Mouse Phenotypes related to Cervical Clear Cell Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.8 ESR1 KITLG KRT14 KRT19 KRT5 KRT8
2 embryo MP:0005380 9.73 ESR1 KITLG KRT18 KRT19 KRT8 PGR
3 integument MP:0010771 9.63 ESR1 KITLG KRT14 KRT19 KRT5 PGR
4 mortality/aging MP:0010768 9.61 ESR1 KITLG KRT14 KRT18 KRT19 KRT5
5 neoplasm MP:0002006 9.02 ESR1 KITLG KRT14 KRT19 PGR

Drugs & Therapeutics for Cervical Clear Cell Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Cervical Clear Cell Adenocarcinoma

Genetic Tests for Cervical Clear Cell Adenocarcinoma

Anatomical Context for Cervical Clear Cell Adenocarcinoma

MalaCards organs/tissues related to Cervical Clear Cell Adenocarcinoma:

41
Cervix, Lung, Skin, Breast, Ovary, Prostate, Pineal

Publications for Cervical Clear Cell Adenocarcinoma

Articles related to Cervical Clear Cell Adenocarcinoma:

# Title Authors Year
1
Cervical clear cell adenocarcinoma with an exceptionally low proliferation index: Report of a case. ( 29326971 )
2018
2
Cervical clear cell adenocarcinoma infected with human papillomavirus type 18 in an adolescent. ( 23849091 )
2014
3
Vaginal laparoscopically assisted radical trachelectomy in cervical clear cell adenocarcinoma. ( 24244219 )
2013
4
Uterine cervical clear-cell adenocarcinoma with a choriocarcinomatous component: a case report. ( 8987325 )
1996

Variations for Cervical Clear Cell Adenocarcinoma

Cosmic variations for Cervical Clear Cell Adenocarcinoma:

9 (show top 50) (show all 93)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM1235014 U2AF1 cervix,NS,carcinoma,adenocarcinoma c.467G>A p.R156H 21:43094670-43094670 5
2 COSM10648 TP53 cervix,NS,carcinoma,adenocarcinoma c.524G>A p.R175H 17:7675088-7675088 5
3 COSM44399 TP53 cervix,NS,carcinoma,adenocarcinoma c.677G>T p.G226V 17:7674286-7674286 5
4 COSM10941 TP53 cervix,NS,carcinoma,adenocarcinoma c.730G>A p.G244S 17:7674233-7674233 5
5 COSM10725 TP53 cervix,NS,carcinoma,adenocarcinoma c.701A>G p.Y234C 17:7674262-7674262 5
6 COSM10662 TP53 cervix,NS,carcinoma,adenocarcinoma c.743G>A p.R248Q 17:7674220-7674220 5
7 COSM11333 TP53 cervix,NS,carcinoma,adenocarcinoma c.499C>T p.Q167* 17:7675113-7675113 5
8 COSM10656 TP53 cervix,NS,carcinoma,adenocarcinoma c.742C>T p.R248W 17:7674221-7674221 5
9 COSM29468 STK11 cervix,NS,carcinoma,adenocarcinoma c.910C>T p.R304W 19:1221996-1221996 5
10 COSM29467 STK11 cervix,NS,carcinoma,adenocarcinoma c.894C>A p.F298L 19:1221980-1221980 5
11 COSM6967953 SF3B1 cervix,NS,carcinoma,adenocarcinoma c.1910C>G p.S637C 2:197402723-197402723 5
12 COSM6967952 SF3B1 cervix,NS,carcinoma,adenocarcinoma c.2323C>G p.R775G 2:197401789-197401789 5
13 COSM6923797 RET cervix,NS,carcinoma,adenocarcinoma c.1132G>A p.D378N 10:43109099-43109099 5
14 COSM5802682 PTPRD cervix,NS,carcinoma,adenocarcinoma c.3530G>A p.R1177H 9:8465650-8465650 5
15 COSM5154 PTEN cervix,NS,carcinoma,adenocarcinoma c.697C>T p.R233* 10:87957915-87957915 5
16 COSM5219 PTEN cervix,NS,carcinoma,adenocarcinoma c.388C>G p.R130G 10:87933147-87933147 5
17 COSM5056 PTEN cervix,NS,carcinoma,adenocarcinoma c.1093G>A p.V365I 10:87965353-87965353 5
18 COSM5152 PTEN cervix,NS,carcinoma,adenocarcinoma c.388C>T p.R130* 10:87933147-87933147 5
19 COSM88109 PTEN cervix,NS,carcinoma,adenocarcinoma c.724G>T p.E242* 10:87957942-87957942 5
20 COSM27133 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1633G>C p.E545Q 3:179218303-179218303 5
21 COSM6147 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1636C>G p.Q546E 3:179218306-179218306 5
22 COSM763 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1633G>A p.E545K 3:179218303-179218303 5
23 COSM29313 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.3129G>A p.M1043I 3:179234286-179234286 5
24 COSM760 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1624G>A p.E542K 3:179218294-179218294 5
25 COSM24712 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1638G>T p.Q546H 3:179218308-179218308 5
26 COSM775 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.3140A>G p.H1047R 3:179234297-179234297 5
27 COSM759 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1616C>G p.P539R 3:179218286-179218286 5
28 COSM12584 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1357G>A p.E453K 3:179210291-179210291 5
29 COSM746 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.263G>A p.R88Q 3:179199088-179199088 5
30 COSM584 NRAS cervix,NS,carcinoma,adenocarcinoma c.182A>G p.Q61R 1:114713908-114713908 5
31 COSM517 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>A p.G12S 12:25245351-25245351 5
32 COSM521 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>A p.G12D 12:25245350-25245350 5
33 COSM532 KRAS cervix,NS,carcinoma,adenocarcinoma c.38G>A p.G13D 12:25245347-25245347 5
34 COSM522 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>C p.G12A 12:25245350-25245350 5
35 COSM516 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>T p.G12C 12:25245351-25245351 5
36 COSM520 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>T p.G12V 12:25245350-25245350 5
37 COSM551 KRAS cervix,NS,carcinoma,adenocarcinoma c.182A>C p.Q61P 12:25227342-25227342 5
38 COSM555 KRAS cervix,NS,carcinoma,adenocarcinoma c.183A>T p.Q61H 12:25227341-25227341 5
39 COSM518 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>C p.G12R 12:25245351-25245351 5
40 COSM96324 KEAP1 cervix,NS,carcinoma,adenocarcinoma c.778C>T p.R260* 19:10492124-10492124 5
41 COSM480 HRAS cervix,NS,carcinoma,adenocarcinoma c.34G>A p.G12S 11:534289-534289 5
42 COSM5945795 GNA11 cervix,NS,carcinoma,adenocarcinoma c.972C>G p.I324M 19:3121071-3121071 5
43 COSM420169 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1436G>C p.R479P 4:152326214-152326214 5
44 COSM22932 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1393C>T p.R465C 4:152328233-152328233 5
45 COSM22975 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1513C>T p.R505C 4:152326137-152326137 5
46 COSM6937049 ERBB2 cervix,NS,carcinoma,adenocarcinoma c.2183C>T p.S728F 17:39723635-39723635 5
47 COSM48358 ERBB2 cervix,NS,carcinoma,adenocarcinoma c.929C>T p.S310F 17:39711955-39711955 5
48 COSM94225 ERBB2 cervix,NS,carcinoma,adenocarcinoma c.929C>A p.S310Y 17:39711955-39711955 5
49 COSM5683 CTNNB1 cervix,NS,carcinoma,adenocarcinoma c.97T>G p.S33A 3:41224609-41224609 5
50 COSM5662 CTNNB1 cervix,NS,carcinoma,adenocarcinoma c.110C>T p.S37F 3:41224622-41224622 5

Expression for Cervical Clear Cell Adenocarcinoma

Search GEO for disease gene expression data for Cervical Clear Cell Adenocarcinoma.

Pathways for Cervical Clear Cell Adenocarcinoma

GO Terms for Cervical Clear Cell Adenocarcinoma

Cellular components related to Cervical Clear Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 ENO2 GP5 KRT14 KRT18 KRT19 KRT5
2 keratin filament GO:0045095 9.46 KRT14 KRT18 KRT5 KRT8
3 apicolateral plasma membrane GO:0016327 9.4 KRT19 KRT8
4 costamere GO:0043034 9.37 KRT19 KRT8
5 intermediate filament GO:0005882 9.35 KRT14 KRT18 KRT19 KRT5 KRT8
6 dystrophin-associated glycoprotein complex GO:0016010 9.32 KRT19 KRT8
7 cell periphery GO:0071944 8.92 KRT14 KRT18 KRT19 KRT8
8 cytosol GO:0005829 10.09 ENO2 ESR1 KRT14 KRT18 KRT19 KRT5

Biological processes related to Cervical Clear Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.67 KRT18 KRT19 KRT8 NCAM1
2 keratinization GO:0031424 9.35 KRT14 KRT18 KRT19 KRT5 KRT8
3 hemidesmosome assembly GO:0031581 9.32 KRT14 KRT5
4 hepatocyte apoptotic process GO:0097284 9.26 KRT18 KRT8
5 cell differentiation involved in embryonic placenta development GO:0060706 9.16 KRT19 KRT8
6 cornification GO:0070268 9.02 KRT14 KRT18 KRT19 KRT5 KRT8

Molecular functions related to Cervical Clear Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 9.16 ESR1 PGR
2 structural constituent of cytoskeleton GO:0005200 9.13 KRT14 KRT19 KRT5
3 scaffold protein binding GO:0097110 8.8 KRT18 KRT5 KRT8

Sources for Cervical Clear Cell Adenocarcinoma

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7 CNVD
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17 ExPASy
19 FMA
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34 ICD10 via Orphanet
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69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
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74 UMLS via Orphanet
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