MCID: CRV026
MIFTS: 33

Cervical Clear Cell Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervical Clear Cell Adenocarcinoma

MalaCards integrated aliases for Cervical Clear Cell Adenocarcinoma:

Name: Cervical Clear Cell Adenocarcinoma 12 15 17 70
Clear Cell Carcinoma of the Cervix Uteri 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5303
NCIt 50 C6344
UMLS 70 C1332912

Summaries for Cervical Clear Cell Adenocarcinoma

Disease Ontology : 12 A cervical adenocarcinoma that derives from epithelial cells which have clear cytoplasm.

MalaCards based summary : Cervical Clear Cell Adenocarcinoma, also known as clear cell carcinoma of the cervix uteri, is related to clear cell adenocarcinoma and diethylstilbestrol syndrome. An important gene associated with Cervical Clear Cell Adenocarcinoma is NAPSA (Napsin A Aspartic Peptidase), and among its related pathways/superpathways are Estrogen signaling pathway (KEGG) and Cell cycle ESR1 regulation of G1/S transition. Affiliated tissues include cervix, breast and ovary, and related phenotype is neoplasm.

Related Diseases for Cervical Clear Cell Adenocarcinoma

Diseases related to Cervical Clear Cell Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 clear cell adenocarcinoma 30.6 PAX8 NAPSA
2 diethylstilbestrol syndrome 11.3
3 adenosarcoma 10.1 PGR ESR1
4 squamous cell papilloma 10.1 KRT14 GP5
5 glassy cell carcinoma of the cervix 10.1 PGR ESR1
6 breast intraductal papillomatosis 10.1 PGR ESR1
7 nipple carcinoma 10.1 PGR ESR1
8 bartholin's gland adenoma 10.1 PGR ESR1
9 bartholin's gland adenoid cystic carcinoma 10.1 PGR ESR1
10 uterine corpus adenosarcoma 10.1 PGR ESR1
11 bartholin's gland benign neoplasm 10.1 PGR ESR1
12 chronic tympanitis 10.1 PGR ESR1
13 vestibular gland benign neoplasm 10.1 PGR ESR1
14 granulomatous endometritis 10.1 PGR ESR1
15 endometritis 10.1 PGR ESR1
16 vulvar syringoma 10.1 PGR ESR1
17 lung leiomyoma 10.1 PGR ESR1
18 breast scirrhous carcinoma 10.1 PGR ESR1
19 benign breast adenomyoepithelioma 10.1 KRT14 ESR1
20 breast papillary carcinoma 10.1 PGR ESR1
21 intravenous leiomyomatosis 10.1 PGR ESR1
22 leiomyomatosis 10.1 PGR ESR1
23 breast adenoid cystic carcinoma 10.1 PGR ESR1
24 intracranial meningioma 10.1 PGR ESR1
25 vulvar leiomyoma 10.1 PGR ESR1
26 bizarre leiomyoma 10.1 PGR ESR1
27 breast malignant phyllodes tumor 10.1 PGR ESR1
28 ovarian primitive germ cell tumor 10.1 NAPSA AFP
29 prostate stromal sarcoma 10.1 PGR ESR1
30 ovarian endodermal sinus tumor 10.1 NAPSA AFP
31 progesterone-receptor negative breast cancer 10.1 PGR ESR1
32 breast osteosarcoma 10.1 PGR ESR1
33 apocrine adenocarcinoma 10.1 PGR ESR1
34 breast neuroendocrine neoplasm 10.1 PGR ESR1
35 gender identity disorder 10.1 PGR ESR1
36 progesterone resistance 10.1 PGR ESR1
37 cribriform carcinoma 10.1 PGR ESR1
38 juvenile nasopharyngeal angiofibroma 10.1 PGR ESR1
39 trigonitis 10.1 PGR ESR1
40 progesterone-receptor positive breast cancer 10.1 PGR ESR1
41 microglandular adenosis 10.1 PGR ESR1
42 vaginal discharge 10.1 PGR ESR1
43 vulvar benign neoplasm 10.1 PGR ESR1
44 glycogen-rich clear cell breast carcinoma 10.1 PGR KRT14
45 estrogen excess 10.1 PGR ESR1
46 endometrial serous adenocarcinoma 10.1 PGR ESR1
47 breast myoepithelial carcinoma 10.1 PGR KRT14
48 polyp of corpus uteri 10.1 PGR KRT14
49 hypertrophy of breast 10.1 PGR ESR1
50 retinitis pigmentosa 47 10.1 PGR ESR1

Graphical network of the top 20 diseases related to Cervical Clear Cell Adenocarcinoma:



Diseases related to Cervical Clear Cell Adenocarcinoma

Symptoms & Phenotypes for Cervical Clear Cell Adenocarcinoma

MGI Mouse Phenotypes related to Cervical Clear Cell Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 AFP ESR1 KRT14 PGR

Drugs & Therapeutics for Cervical Clear Cell Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Cervical Clear Cell Adenocarcinoma

Genetic Tests for Cervical Clear Cell Adenocarcinoma

Anatomical Context for Cervical Clear Cell Adenocarcinoma

MalaCards organs/tissues related to Cervical Clear Cell Adenocarcinoma:

40
Cervix, Breast, Ovary, Testis, Smooth Muscle, Kidney, Liver

Publications for Cervical Clear Cell Adenocarcinoma

Articles related to Cervical Clear Cell Adenocarcinoma:

(show all 18)
# Title Authors PMID Year
1
Diethylstilbestrol exposure during pregnancy with primary clear cell carcinoma of the cervix in an 8-year-old granddaughter: a multigenerational effect of endocrine disruptors? 61
33147330 2021
2
Primary Clear Cell Adenocarcinoma of the Cervix: A Clinical Analysis of 18 Cases without Exposure to Diethylstilbestrol. 61
31049066 2019
3
Cervical clear cell adenocarcinoma with an exceptionally low proliferation index: Report of a case. 61
29326971 2018
4
Incidence rates and risks of diethylstilbestrol-related clear-cell adenocarcinoma of the vagina and cervix: Update after 40-year follow-up. 61
28689666 2017
5
DES daughters in France: experts' points of view on the various genital, uterine and obstetric pathologies, and in utero DES exposure. 61
24534146 2014
6
Cervical clear cell adenocarcinoma infected with human papillomavirus type 18 in an adolescent. 61
23849091 2014
7
Vaginal laparoscopically assisted radical trachelectomy in cervical clear cell adenocarcinoma. 61
24244219 2013
8
High-risk human papillomavirus seems not involved in DES-related and of limited importance in nonDES related clear-cell carcinoma of the cervix. 61
21620450 2011
9
Clear cell adenocarcinoma of the uterine cervix in a young pregnant woman: a case report with immunohistochemical study. 61
20054717 2011
10
Clear cell adenocarcinoma of the uterine cervix arising from a background of cervical endometriosis. 61
19095810 2009
11
[The first Congolese case of cervical clear cell adenocarcinoma]. 61
15255353 2004
12
Clear cell adenocarcinoma of the cervix associated with a rare genitourinary malformation. 61
11094228 2000
13
Cytologic examination to detect clear cell adenocarcinoma of the vagina or cervix. 61
10600286 1999
14
Uterine cervical clear-cell adenocarcinoma with a choriocarcinomatous component: a case report. 61
8987325 1996
15
Pathology of the vagina. 61
1678972 1991
16
Clear cell adenocarcinoma of the vagina and cervix. A report of the Central Netherlands Registry with emphasis on early detection and prognosis. 61
2004313 1991
17
Pelvic exenteration in clear cell adenocarcinoma of the vagina and cervix. 61
2767532 1989
18
Establishment and characterization of cell line SFCC from clear cell adenocarcinoma of the uterine cervix. 61
2472868 1989

Variations for Cervical Clear Cell Adenocarcinoma

Cosmic variations for Cervical Clear Cell Adenocarcinoma:

9 (show top 50) (show all 345)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM144650860 TP53 cervix,NS,carcinoma,adenocarcinoma c.584A>G p.Y195C 17:7674262-7674262 3
2 COSM144651115 TP53 cervix,NS,carcinoma,adenocarcinoma c.626G>A p.R209Q 17:7674220-7674220 3
3 COSM112253879 TP53 cervix,NS,carcinoma,adenocarcinoma c.742C>T p.R248W 17:7674221-7674221 3
4 COSM87935416 TP53 cervix,NS,carcinoma,adenocarcinoma c.499C>T p.Q167* 17:7675113-7675113 3
5 COSM142560569 TP53 cervix,NS,carcinoma,clear cell carcinoma c.700C>T p.R234C 17:7673803-7673803 3
6 COSM143156843 TP53 cervix,NS,carcinoma,adenocarcinoma c.266G>A p.R89Q 17:7674220-7674220 3
7 COSM111758336 TP53 cervix,NS,carcinoma,adenocarcinoma c.701A>G p.Y234C 17:7674262-7674262 3
8 COSM93303215 TP53 cervix,NS,carcinoma,adenocarcinoma c.677G>T p.G226V 17:7674286-7674286 3
9 COSM144013689 TP53 cervix,NS,carcinoma,clear cell carcinoma c.784C>T p.R262C 17:7673803-7673803 3
10 COSM122733941 TP53 cervix,NS,carcinoma,adenocarcinoma c.305A>G p.Y102C 17:7674262-7674262 3
11 COSM112374468 TP53 cervix,NS,carcinoma,adenocarcinoma c.677G>T p.G226V 17:7674286-7674286 3
12 COSM122271832 TP53 cervix,NS,carcinoma,clear cell carcinoma c.421C>T p.R141C 17:7673803-7673803 3
13 COSM143157028 TP53 cervix,NS,carcinoma,clear cell carcinoma c.340C>T p.R114C 17:7673803-7673803 3
14 COSM111879853 TP53 cervix,NS,carcinoma,adenocarcinoma c.677G>T p.G226V 17:7674286-7674286 3
15 COSM144682712 TP53 cervix,NS,carcinoma,adenocarcinoma c.382C>T p.Q128* 17:7675113-7675113 3
16 COSM122302302 TP53 cervix,NS,carcinoma,adenocarcinoma c.103C>T p.Q35* 17:7675113-7675113 3
17 COSM144116151 TP53 cervix,NS,carcinoma,adenocarcinoma c.644G>T p.G215V 17:7674286-7674286 3
18 COSM143484735 TP53 cervix,NS,carcinoma,adenocarcinoma c.560G>T p.G187V 17:7674286-7674286 3
19 COSM144409660 TP53 cervix,NS,carcinoma,adenocarcinoma c.560G>T p.G187V 17:7674286-7674286 3
20 COSM121910283 TP53 cervix,NS,carcinoma,adenocarcinoma c.103C>T p.Q35* 17:7675113-7675113 3
21 COSM144651456 TP53 cervix,NS,carcinoma,clear cell carcinoma c.700C>T p.R234C 17:7673803-7673803 3
22 COSM87898709 TP53 cervix,NS,carcinoma,adenocarcinoma c.742C>T p.R248W 17:7674221-7674221 3
23 COSM144186978 TP53 cervix,NS,carcinoma,adenocarcinoma c.200G>T p.G67V 17:7674286-7674286 3
24 COSM106053452 TP53 cervix,NS,carcinoma,clear cell carcinoma c.817C>T p.R273C 17:7673803-7673803 3
25 COSM145045823 TP53 cervix,NS,carcinoma,adenocarcinoma c.382C>T p.Q128* 17:7675113-7675113 3
26 COSM144310429 TP53 cervix,NS,carcinoma,adenocarcinoma c.625C>T p.R209W 17:7674221-7674221 3
27 COSM93183630 TP53 cervix,NS,carcinoma,adenocarcinoma c.743G>A p.R248Q 17:7674220-7674220 3
28 COSM144013367 TP53 cervix,NS,carcinoma,adenocarcinoma c.710G>A p.R237Q 17:7674220-7674220 3
29 COSM106053434 TP53 cervix,NS,carcinoma,adenocarcinoma c.742C>T p.R248W 17:7674221-7674221 3
30 COSM122734408 TP53 cervix,NS,carcinoma,clear cell carcinoma c.421C>T p.R141C 17:7673803-7673803 3
31 COSM142560012 TP53 cervix,NS,carcinoma,adenocarcinoma c.584A>G p.Y195C 17:7674262-7674262 3
32 COSM122734399 TP53 cervix,NS,carcinoma,adenocarcinoma c.346C>T p.R116W 17:7674221-7674221 3
33 COSM144334467 TP53 cervix,NS,carcinoma,adenocarcinoma c.382C>T p.Q128* 17:7675113-7675113 3
34 COSM144310011 TP53 cervix,NS,carcinoma,adenocarcinoma c.584A>G p.Y195C 17:7674262-7674262 3
35 COSM93183975 TP53 cervix,NS,carcinoma,adenocarcinoma c.742C>T p.R248W 17:7674221-7674221 3
36 COSM142560553 TP53 cervix,NS,carcinoma,adenocarcinoma c.625C>T p.R209W 17:7674221-7674221 3
37 COSM143370668 TP53 cervix,NS,carcinoma,adenocarcinoma c.584A>G p.Y195C 17:7674262-7674262 3
38 COSM111758883 TP53 cervix,NS,carcinoma,clear cell carcinoma c.817C>T p.R273C 17:7673803-7673803 3
39 COSM142837551 TP53 cervix,NS,carcinoma,adenocarcinoma c.742C>T p.R248W 17:7674221-7674221 3
40 COSM111790424 TP53 cervix,NS,carcinoma,adenocarcinoma c.499C>T p.Q167* 17:7675113-7675113 3
41 COSM144778606 TP53 cervix,NS,carcinoma,adenocarcinoma c.560G>T p.G187V 17:7674286-7674286 3
42 COSM142939594 TP53 cervix,NS,carcinoma,adenocarcinoma c.677G>T p.G226V 17:7674286-7674286 3
43 COSM144111084 TP53 cervix,NS,carcinoma,adenocarcinoma c.22C>T p.Q8* 17:7675113-7675113 3
44 COSM144013676 TP53 cervix,NS,carcinoma,adenocarcinoma c.709C>T p.R237W 17:7674221-7674221 3
45 COSM106084061 TP53 cervix,NS,carcinoma,adenocarcinoma c.499C>T p.Q167* 17:7675113-7675113 3
46 COSM143182864 TP53 cervix,NS,carcinoma,adenocarcinoma c.22C>T p.Q8* 17:7675113-7675113 3
47 COSM93183394 TP53 cervix,NS,carcinoma,adenocarcinoma c.701A>G p.Y234C 17:7674262-7674262 3
48 COSM112253189 TP53 cervix,NS,carcinoma,adenocarcinoma c.701A>G p.Y234C 17:7674262-7674262 3
49 COSM144013181 TP53 cervix,NS,carcinoma,adenocarcinoma c.668A>G p.Y223C 17:7674262-7674262 3
50 COSM144087106 TP53 cervix,NS,carcinoma,adenocarcinoma c.266G>A p.R89Q 17:7674220-7674220 3

Expression for Cervical Clear Cell Adenocarcinoma

Search GEO for disease gene expression data for Cervical Clear Cell Adenocarcinoma.

Pathways for Cervical Clear Cell Adenocarcinoma

Pathways related to Cervical Clear Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.94 PGR KRT14 ESR1
2
Show member pathways
10.79 PGR ESR1

GO Terms for Cervical Clear Cell Adenocarcinoma

Biological processes related to Cervical Clear Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone mediated signaling pathway GO:0043401 9.16 PGR ESR1
2 intracellular steroid hormone receptor signaling pathway GO:0030518 8.96 PGR ESR1
3 ovulation from ovarian follicle GO:0001542 8.62 PGR AFP

Molecular functions related to Cervical Clear Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.43 PGR PAX8 ESR1
2 nuclear receptor activity GO:0004879 9.16 PGR ESR1
3 steroid binding GO:0005496 8.96 PGR ESR1
4 steroid hormone receptor activity GO:0003707 8.62 PGR ESR1

Sources for Cervical Clear Cell Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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