MCID: CRV026
MIFTS: 35

Cervical Clear Cell Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervical Clear Cell Adenocarcinoma

MalaCards integrated aliases for Cervical Clear Cell Adenocarcinoma:

Name: Cervical Clear Cell Adenocarcinoma 12 15 17 74
Clear Cell Carcinoma of the Cervix Uteri 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5303
NCIt 51 C6344
UMLS 74 C1332912

Summaries for Cervical Clear Cell Adenocarcinoma

Disease Ontology : 12 A cervical adenocarcinoma that derives from epithelial cells which have clear cytoplasm.

MalaCards based summary : Cervical Clear Cell Adenocarcinoma, also known as clear cell carcinoma of the cervix uteri, is related to diethylstilbestrol syndrome and epidermolysis bullosa simplex, localized. An important gene associated with Cervical Clear Cell Adenocarcinoma is NAPSA (Napsin A Aspartic Peptidase), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include breast, cervix and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Cervical Clear Cell Adenocarcinoma

Diseases related to Cervical Clear Cell Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 277)
# Related Disease Score Top Affiliating Genes
1 diethylstilbestrol syndrome 11.3
2 epidermolysis bullosa simplex, localized 10.5 KRT14 KRT5
3 epidermolysis bullosa simplex, generalized 10.5 KRT14 KRT5
4 epidermolysis bullosa simplex with mottled pigmentation 10.5 KRT14 KRT5
5 epidermolysis bullosa simplex, autosomal recessive 1 10.5 KRT14 KRT5
6 cryptogenic cirrhosis 10.5 KRT18 KRT8
7 neurenteric cyst 10.5 KRT18 KRT8
8 breast squamous cell carcinoma 10.5 KRT14 KRT5
9 combined thymoma 10.5 KRT5 PAX8
10 lichen planopilaris 10.5 KRT14 KRT5
11 ameloblastic carcinoma 10.5 CDKN2A KRT14
12 papillary adenoma 10.4 KRT7 NAPSA
13 breast metaplastic carcinoma 10.4 KRT5 PGR
14 thymus adenocarcinoma 10.4 KRT7 NAPSA
15 vulvar dystrophy 10.4 CDKN2A PGR
16 spiradenoma 10.4 KRT14 KRT7
17 bladder benign neoplasm 10.4 KRT7 PAX8
18 krukenberg carcinoma 10.4 KRT7 NAPSA
19 bizarre leiomyoma 10.4 CDKN2A PGR
20 progesterone resistance 10.4 ESR1 PGR
21 bartholin's gland disease 10.4 CDKN2A PGR
22 hidrocystoma 10.4 KRT7 KRT8
23 progesterone-receptor positive breast cancer 10.4 ESR1 PGR
24 vulvar benign neoplasm 10.4 ESR1 PGR
25 peritoneal benign neoplasm 10.4 ESR1 PGR
26 gender identity disorder 10.4 ESR1 PGR
27 trigonitis 10.4 ESR1 PGR
28 nephrogenic adenoma of urinary bladder 10.4 KRT7 PAX8
29 nephrogenic adenoma 10.4 KRT7 PAX8
30 epithelioid trophoblastic tumor 10.4 KRT18 KRT7
31 adenoid squamous cell carcinoma 10.4 KRT7 KRT8
32 keratinizing squamous cell carcinoma 10.4 CDKN2A KRT5
33 deep angioma 10.4 ESR1 PGR
34 breast adenoid cystic carcinoma 10.4 ESR1 PGR
35 optic nerve sheath meningioma 10.4 CDKN2A KRT5
36 vulvar leiomyoma 10.4 ESR1 PGR
37 nodular hidradenoma 10.4 KITLG KRT7
38 endolymphatic sac tumor 10.4 KRT7 KRT8
39 breast medullary carcinoma 10.4 ESR1 PGR
40 diffuse peritoneal leiomyomatosis 10.4 ESR1 PGR
41 synchronous bilateral breast carcinoma 10.4 ESR1 PGR
42 mixed type thymoma 10.4 PAX8 SYP
43 breast scirrhous carcinoma 10.4 ESR1 PGR
44 glassy cell carcinoma of the cervix 10.4 ESR1 PGR
45 papillary serous adenocarcinoma 10.4 KRT7 PGR
46 water-clear cell adenoma 10.4 PAX8 SYP
47 balloon cell malignant melanoma 10.4 KRT5 KRT7
48 eccrine papillary adenocarcinoma 10.4 KRT7 PGR
49 benign mesothelioma 10.4 KRT5 KRT7
50 ameloblastoma 10.4 KRT14 KRT18 KRT8

Graphical network of the top 20 diseases related to Cervical Clear Cell Adenocarcinoma:



Diseases related to Cervical Clear Cell Adenocarcinoma

Symptoms & Phenotypes for Cervical Clear Cell Adenocarcinoma

GenomeRNAi Phenotypes related to Cervical Clear Cell Adenocarcinoma according to GeneCards Suite gene sharing:

27 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.58 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.58 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.58 KRT18 KRT5
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.58 KRT5 KRT8
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.58 KRT5
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.58 KRT18
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.58 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.58 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.58 KRT18 KRT5 KRT7 KRT8
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.58 KRT7
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.58 KRT18
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.58 KRT5 KRT7

MGI Mouse Phenotypes related to Cervical Clear Cell Adenocarcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.17 CDKN2A ENO2 ESR1 KITLG KRT14 KRT19
2 growth/size/body region MP:0005378 10 CDKN2A ENO2 ESR1 KITLG KRT14 KRT18
3 embryo MP:0005380 9.97 CDKN2A ESR1 KITLG KRT18 KRT19 KRT8
4 digestive/alimentary MP:0005381 9.95 CDKN2A ESR1 KITLG KRT14 KRT19 KRT5
5 mortality/aging MP:0010768 9.93 CDKN2A ESR1 KITLG KRT14 KRT18 KRT19
6 endocrine/exocrine gland MP:0005379 9.92 CDKN2A ESR1 KITLG KRT14 KRT19 MAPK8IP1
7 neoplasm MP:0002006 9.43 CDKN2A ESR1 KITLG KRT14 KRT19 PGR
8 reproductive system MP:0005389 9.28 CDKN2A ESR1 KITLG KRT14 KRT19 KRT8

Drugs & Therapeutics for Cervical Clear Cell Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Cervical Clear Cell Adenocarcinoma

Genetic Tests for Cervical Clear Cell Adenocarcinoma

Anatomical Context for Cervical Clear Cell Adenocarcinoma

MalaCards organs/tissues related to Cervical Clear Cell Adenocarcinoma:

42
Breast, Cervix, Lung, Ovary, Thymus, Skin, Testis

Publications for Cervical Clear Cell Adenocarcinoma

Articles related to Cervical Clear Cell Adenocarcinoma:

# Title Authors Year
1
Cervical clear cell adenocarcinoma with an exceptionally low proliferation index: Report of a case. ( 29326971 )
2018
2
Cervical clear cell adenocarcinoma infected with human papillomavirus type 18 in an adolescent. ( 23849091 )
2014
3
Vaginal laparoscopically assisted radical trachelectomy in cervical clear cell adenocarcinoma. ( 24244219 )
2013
4
Uterine cervical clear-cell adenocarcinoma with a choriocarcinomatous component: a case report. ( 8987325 )
1996

Variations for Cervical Clear Cell Adenocarcinoma

Cosmic variations for Cervical Clear Cell Adenocarcinoma:

9 (show top 50) (show all 96)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM1235014 U2AF1 cervix,NS,carcinoma,adenocarcinoma c.467G>A p.R156H 21:43094670-43094670 0
2 COSM10656 TP53 cervix,NS,carcinoma,adenocarcinoma c.742C>T p.R248W 17:7674221-7674221 0
3 COSM11333 TP53 cervix,NS,carcinoma,adenocarcinoma c.499C>T p.Q167* 17:7675113-7675113 0
4 COSM10662 TP53 cervix,NS,carcinoma,adenocarcinoma c.743G>A p.R248Q 17:7674220-7674220 0
5 COSM10725 TP53 cervix,NS,carcinoma,adenocarcinoma c.701A>G p.Y234C 17:7674262-7674262 0
6 COSM10941 TP53 cervix,NS,carcinoma,adenocarcinoma c.730G>A p.G244S 17:7674233-7674233 0
7 COSM10659 TP53 cervix,NS,carcinoma,clear cell carcinoma c.817C>T p.R273C 17:7673803-7673803 0
8 COSM44399 TP53 cervix,NS,carcinoma,adenocarcinoma c.677G>T p.G226V 17:7674286-7674286 0
9 COSM10648 TP53 cervix,NS,carcinoma,adenocarcinoma c.524G>A p.R175H 17:7675088-7675088 0
10 COSM29467 STK11 cervix,NS,carcinoma,adenocarcinoma c.894C>A p.F298L 19:1221980-1221980 0
11 COSM29468 STK11 cervix,NS,carcinoma,adenocarcinoma c.910C>T p.R304W 19:1221996-1221996 0
12 COSM6967952 SF3B1 cervix,NS,carcinoma,adenocarcinoma c.2323C>G p.R775G 2:197401789-197401789 0
13 COSM6967953 SF3B1 cervix,NS,carcinoma,adenocarcinoma c.1910C>G p.S637C 2:197402723-197402723 0
14 COSM6923797 RET cervix,NS,carcinoma,adenocarcinoma c.1132G>A p.D378N 10:43109099-43109099 0
15 COSM5802682 PTPRD cervix,NS,carcinoma,adenocarcinoma c.3530G>A p.R1177H 9:8465650-8465650 0
16 COSM88109 PTEN cervix,NS,carcinoma,adenocarcinoma c.724G>T p.E242* 10:87957942-87957942 0
17 COSM5152 PTEN cervix,NS,carcinoma,adenocarcinoma c.388C>T p.R130* 10:87933147-87933147 0
18 COSM5056 PTEN cervix,NS,carcinoma,adenocarcinoma c.1093G>A p.V365I 10:87965353-87965353 0
19 COSM5154 PTEN cervix,NS,carcinoma,adenocarcinoma c.697C>T p.R233* 10:87957915-87957915 0
20 COSM5219 PTEN cervix,NS,carcinoma,adenocarcinoma c.388C>G p.R130G 10:87933147-87933147 0
21 COSM2927185 PPP2R1A cervix,NS,carcinoma,clear cell carcinoma c.770G>T p.W257L 19:52213073-52213073 0
22 COSM6951151 PIK3R1 cervix,NS,carcinoma,clear cell carcinoma c.2069C>T p.S690F 5:68297495-68297495 0
23 COSM27133 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1633G>C p.E545Q 3:179218303-179218303 0
24 COSM775 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.3140A>G p.H1047R 3:179234297-179234297 0
25 COSM746 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.263G>A p.R88Q 3:179199088-179199088 0
26 COSM12584 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1357G>A p.E453K 3:179210291-179210291 0
27 COSM759 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1616C>G p.P539R 3:179218286-179218286 0
28 COSM763 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1633G>A p.E545K 3:179218303-179218303 0
29 COSM24712 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1638G>T p.Q546H 3:179218308-179218308 0
30 COSM760 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1624G>A p.E542K 3:179218294-179218294 0
31 COSM29313 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.3129G>A p.M1043I 3:179234286-179234286 0
32 COSM6147 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1636C>G p.Q546E 3:179218306-179218306 0
33 COSM584 NRAS cervix,NS,carcinoma,adenocarcinoma c.182A>G p.Q61R 1:114713908-114713908 0
34 COSM6951154 MAX cervix,NS,carcinoma,clear cell carcinoma c.280C>G p.L94V 14:65077928-65077928 0
35 COSM546 KRAS cervix,NS,carcinoma,adenocarcinoma c.175G>A p.A59T 12:25227349-25227349 0
36 COSM518 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>C p.G12R 12:25245351-25245351 0
37 COSM517 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>A p.G12S 12:25245351-25245351 0
38 COSM555 KRAS cervix,NS,carcinoma,adenocarcinoma c.183A>T p.Q61H 12:25227341-25227341 0
39 COSM551 KRAS cervix,NS,carcinoma,adenocarcinoma c.182A>C p.Q61P 12:25227342-25227342 0
40 COSM520 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>T p.G12V 12:25245350-25245350 0
41 COSM516 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>T p.G12C 12:25245351-25245351 0
42 COSM521 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>A p.G12D 12:25245350-25245350 0
43 COSM532 KRAS cervix,NS,carcinoma,adenocarcinoma c.38G>A p.G13D 12:25245347-25245347 0
44 COSM522 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>C p.G12A 12:25245350-25245350 0
45 COSM96324 KEAP1 cervix,NS,carcinoma,adenocarcinoma c.778C>T p.R260* 19:10492124-10492124 0
46 COSM480 HRAS cervix,NS,carcinoma,adenocarcinoma c.34G>A p.G12S 11:534289-534289 0
47 COSM5945795 GNA11 cervix,NS,carcinoma,adenocarcinoma c.972C>G p.I324M 19:3121071-3121071 0
48 COSM22975 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1513C>T p.R505C 4:152326137-152326137 0
49 COSM22932 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1393C>T p.R465C 4:152328233-152328233 0
50 COSM420169 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1436G>C p.R479P 4:152326214-152326214 0

Expression for Cervical Clear Cell Adenocarcinoma

Search GEO for disease gene expression data for Cervical Clear Cell Adenocarcinoma.

Pathways for Cervical Clear Cell Adenocarcinoma

Pathways related to Cervical Clear Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.14 KITLG KRT14 KRT18 KRT19 KRT5 KRT7
2 12.04 KRT18 KRT19 KRT5 KRT7 KRT8
3
Show member pathways
11.89 KRT14 KRT18 KRT19 KRT5 KRT7 KRT8
4 11.61 GP5 KITLG NCAM1
5
Show member pathways
11.13 KRT14 KRT18 KRT19 KRT5 KRT7 KRT8
6 10.98 ESR1 KRT19 KRT8

GO Terms for Cervical Clear Cell Adenocarcinoma

Cellular components related to Cervical Clear Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 ENO2 GP5 KRT14 KRT18 KRT19 KRT5
2 cell periphery GO:0071944 9.46 KRT14 KRT18 KRT19 KRT8
3 apicolateral plasma membrane GO:0016327 9.43 KRT19 KRT8
4 costamere GO:0043034 9.4 KRT19 KRT8
5 dystrophin-associated glycoprotein complex GO:0016010 9.37 KRT19 KRT8
6 keratin filament GO:0045095 9.35 KRT14 KRT18 KRT5 KRT7 KRT8
7 intermediate filament GO:0005882 9.1 KRT14 KRT18 KRT19 KRT5 KRT7 KRT8
8 cytosol GO:0005829 10.1 CDKN2A ENO2 ESR1 KRT14 KRT18 KRT19

Biological processes related to Cervical Clear Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.65 KRT18 KRT19 KRT7 KRT8 NCAM1
2 keratinization GO:0031424 9.43 KRT14 KRT18 KRT19 KRT5 KRT7 KRT8
3 hemidesmosome assembly GO:0031581 9.37 KRT14 KRT5
4 hepatocyte apoptotic process GO:0097284 9.32 KRT18 KRT8
5 cell differentiation involved in embryonic placenta development GO:0060706 9.16 KRT19 KRT8
6 cornification GO:0070268 9.1 KRT14 KRT18 KRT19 KRT5 KRT7 KRT8

Molecular functions related to Cervical Clear Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.13 KRT14 KRT19 KRT5
2 scaffold protein binding GO:0097110 8.8 KRT18 KRT5 KRT8

Sources for Cervical Clear Cell Adenocarcinoma

3 CDC
7 CNVD
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11 DGIdb
17 EFO
18 ExPASy
20 FMA
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59 OMIM via Orphanet
63 PubMed
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70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
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