MCID: CRV026
MIFTS: 37

Cervical Clear Cell Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervical Clear Cell Adenocarcinoma

MalaCards integrated aliases for Cervical Clear Cell Adenocarcinoma:

Name: Cervical Clear Cell Adenocarcinoma 12 15 17 72
Clear Cell Carcinoma of the Cervix Uteri 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5303
NCIt 50 C6344
UMLS 72 C1332912

Summaries for Cervical Clear Cell Adenocarcinoma

Disease Ontology : 12 A cervical adenocarcinoma that derives from epithelial cells which have clear cytoplasm.

MalaCards based summary : Cervical Clear Cell Adenocarcinoma, also known as clear cell carcinoma of the cervix uteri, is related to diethylstilbestrol syndrome and neurenteric cyst. An important gene associated with Cervical Clear Cell Adenocarcinoma is NAPSA (Napsin A Aspartic Peptidase), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include cervix, and related phenotypes are cellular and growth/size/body region

Related Diseases for Cervical Clear Cell Adenocarcinoma

Diseases related to Cervical Clear Cell Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 280)
# Related Disease Score Top Affiliating Genes
1 diethylstilbestrol syndrome 11.4
2 neurenteric cyst 10.7 KRT8 KRT18
3 combined thymoma 10.7 PAX8 KRT5
4 lichen planopilaris 10.7 KRT5 KRT14
5 epidermolysis bullosa simplex, autosomal recessive 1 10.7 KRT5 KRT14
6 nephrogenic adenoma of urinary bladder 10.6 PAX8 KRT7
7 nephrogenic adenoma 10.6 PAX8 KRT7
8 breast metaplastic carcinoma 10.6 PGR KRT5
9 bartholin's gland adenoma 10.6 PGR ESR1
10 vestibular gland benign neoplasm 10.6 PGR ESR1
11 krukenberg carcinoma 10.6 NAPSA KRT7
12 lung leiomyoma 10.6 PGR ESR1
13 vulvar syringoma 10.6 PGR ESR1
14 vulvar dystrophy 10.6 PGR CDKN2A
15 glassy cell carcinoma of the cervix 10.6 PGR ESR1
16 ameloblastic carcinoma 10.6 KRT14 CDKN2A
17 bladder benign neoplasm 10.6 PAX8 KRT7
18 endolymphatic sac tumor 10.6 KRT8 KRT7
19 spiradenoma 10.6 KRT7 KRT14
20 vulvar leiomyoma 10.6 PGR ESR1
21 trigonitis 10.6 PGR ESR1
22 vulvar benign neoplasm 10.6 PGR ESR1
23 epidermolysis bullosa simplex, localized 10.6 KRT5 KRT14
24 bizarre leiomyoma 10.6 PGR CDKN2A
25 optic nerve sheath meningioma 10.6 KRT5 CDKN2A
26 breast scirrhous carcinoma 10.6 PGR ESR1
27 eccrine papillary adenocarcinoma 10.6 PGR KRT7
28 breast medullary carcinoma 10.5 PGR ESR1
29 breast squamous cell carcinoma 10.5 KRT5 KRT14
30 keratinizing squamous cell carcinoma 10.5 KRT5 CDKN2A
31 papillary adenoma 10.5 NAPSA KRT7
32 hidrocystoma 10.5 KRT8 KRT7
33 ameloblastoma 10.5 KRT8 KRT18 KRT14
34 adenoid squamous cell carcinoma 10.5 KRT8 KRT7
35 ceruminoma 10.5 KRT7 KRT5
36 balloon cell malignant melanoma 10.5 KRT7 KRT5
37 water-clear cell adenoma 10.5 SYP PAX8
38 bile duct adenoma 10.5 KRT7 CDKN2A
39 idiopathic corneal edema 10.5 KRT8 KRT19
40 sarcomatoid squamous cell skin carcinoma 10.5 MAPK8IP1 KRT8 KRT5
41 epithelioid trophoblastic tumor 10.5 KRT7 KRT18
42 progesterone-receptor positive breast cancer 10.5 PGR ESR1
43 malignant spiradenoma 10.5 KRT7 KRT5
44 benign mesothelioma 10.5 KRT7 KRT5
45 mixed type thymoma 10.5 SYP PAX8
46 progesterone resistance 10.5 PGR ESR1
47 bile duct mucoepidermoid carcinoma 10.5 KRT7 KRT5
48 benign metastasizing leiomyoma 10.5 PGR KRT7
49 breast papillary carcinoma 10.5 SYP KRT5
50 thymus adenocarcinoma 10.5 NAPSA KRT7

Graphical network of the top 20 diseases related to Cervical Clear Cell Adenocarcinoma:



Diseases related to Cervical Clear Cell Adenocarcinoma

Symptoms & Phenotypes for Cervical Clear Cell Adenocarcinoma

MGI Mouse Phenotypes related to Cervical Clear Cell Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.17 CDKN2A ENO2 ESR1 KITLG KRT14 KRT19
2 growth/size/body region MP:0005378 10 CDKN2A ENO2 ESR1 KITLG KRT14 KRT18
3 embryo MP:0005380 9.97 CDKN2A ESR1 KITLG KRT18 KRT19 KRT8
4 digestive/alimentary MP:0005381 9.95 CDKN2A ESR1 KITLG KRT14 KRT19 KRT5
5 mortality/aging MP:0010768 9.93 CDKN2A ESR1 KITLG KRT14 KRT18 KRT19
6 endocrine/exocrine gland MP:0005379 9.92 CDKN2A ESR1 KITLG KRT14 KRT19 MAPK8IP1
7 neoplasm MP:0002006 9.43 CDKN2A ESR1 KITLG KRT14 KRT19 PGR
8 reproductive system MP:0005389 9.28 CDKN2A ESR1 KITLG KRT14 KRT19 KRT8

Drugs & Therapeutics for Cervical Clear Cell Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Cervical Clear Cell Adenocarcinoma

Genetic Tests for Cervical Clear Cell Adenocarcinoma

Anatomical Context for Cervical Clear Cell Adenocarcinoma

MalaCards organs/tissues related to Cervical Clear Cell Adenocarcinoma:

41
Cervix

Publications for Cervical Clear Cell Adenocarcinoma

Articles related to Cervical Clear Cell Adenocarcinoma:

(show all 17)
# Title Authors PMID Year
1
Primary Clear Cell Adenocarcinoma of the Cervix: A Clinical Analysis of 18 Cases without Exposure to Diethylstilbestrol. 38
31049066 2019
2
Cervical clear cell adenocarcinoma with an exceptionally low proliferation index: Report of a case. 38
29326971 2018
3
Incidence rates and risks of diethylstilbestrol-related clear-cell adenocarcinoma of the vagina and cervix: Update after 40-year follow-up. 38
28689666 2017
4
DES daughters in France: experts' points of view on the various genital, uterine and obstetric pathologies, and in utero DES exposure. 38
24534146 2014
5
Cervical clear cell adenocarcinoma infected with human papillomavirus type 18 in an adolescent. 38
23849091 2014
6
Vaginal laparoscopically assisted radical trachelectomy in cervical clear cell adenocarcinoma. 38
24244219 2013
7
High-risk human papillomavirus seems not involved in DES-related and of limited importance in nonDES related clear-cell carcinoma of the cervix. 38
21620450 2011
8
Clear cell adenocarcinoma of the uterine cervix in a young pregnant woman: a case report with immunohistochemical study. 38
20054717 2011
9
Clear cell adenocarcinoma of the uterine cervix arising from a background of cervical endometriosis. 38
19095810 2009
10
[The first Congolese case of cervical clear cell adenocarcinoma]. 38
15255353 2004
11
Clear cell adenocarcinoma of the cervix associated with a rare genitourinary malformation. 38
11094228 2000
12
Cytologic examination to detect clear cell adenocarcinoma of the vagina or cervix. 38
10600286 1999
13
Uterine cervical clear-cell adenocarcinoma with a choriocarcinomatous component: a case report. 38
8987325 1996
14
Pathology of the vagina. 38
1678972 1991
15
Clear cell adenocarcinoma of the vagina and cervix. A report of the Central Netherlands Registry with emphasis on early detection and prognosis. 38
2004313 1991
16
Pelvic exenteration in clear cell adenocarcinoma of the vagina and cervix. 38
2767532 1989
17
Establishment and characterization of cell line SFCC from clear cell adenocarcinoma of the uterine cervix. 38
2472868 1989

Variations for Cervical Clear Cell Adenocarcinoma

Cosmic variations for Cervical Clear Cell Adenocarcinoma:

9 (show top 50) (show all 96)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM1235014 U2AF1 cervix,NS,carcinoma,adenocarcinoma c.467G>A p.R156H 21:43094670-43094670 3
2 COSM10648 TP53 cervix,NS,carcinoma,adenocarcinoma c.524G>A p.R175H 17:7675088-7675088 3
3 COSM44399 TP53 cervix,NS,carcinoma,adenocarcinoma c.677G>T p.G226V 17:7674286-7674286 3
4 COSM10659 TP53 cervix,NS,carcinoma,clear cell carcinoma c.817C>T p.R273C 17:7673803-7673803 3
5 COSM10941 TP53 cervix,NS,carcinoma,adenocarcinoma c.730G>A p.G244S 17:7674233-7674233 3
6 COSM10725 TP53 cervix,NS,carcinoma,adenocarcinoma c.701A>G p.Y234C 17:7674262-7674262 3
7 COSM10662 TP53 cervix,NS,carcinoma,adenocarcinoma c.743G>A p.R248Q 17:7674220-7674220 3
8 COSM11333 TP53 cervix,NS,carcinoma,adenocarcinoma c.499C>T p.Q167* 17:7675113-7675113 3
9 COSM10656 TP53 cervix,NS,carcinoma,adenocarcinoma c.742C>T p.R248W 17:7674221-7674221 3
10 COSM29468 STK11 cervix,NS,carcinoma,adenocarcinoma c.910C>T p.R304W 19:1221996-1221996 3
11 COSM29467 STK11 cervix,NS,carcinoma,adenocarcinoma c.894C>A p.F298L 19:1221980-1221980 3
12 COSM6967953 SF3B1 cervix,NS,carcinoma,adenocarcinoma c.1910C>G p.S637C 2:197402723-197402723 3
13 COSM6967952 SF3B1 cervix,NS,carcinoma,adenocarcinoma c.2323C>G p.R775G 2:197401789-197401789 3
14 COSM6923797 RET cervix,NS,carcinoma,adenocarcinoma c.1132G>A p.D378N 10:43109099-43109099 3
15 COSM5802682 PTPRD cervix,NS,carcinoma,adenocarcinoma c.3530G>A p.R1177H 9:8465650-8465650 3
16 COSM5154 PTEN cervix,NS,carcinoma,adenocarcinoma c.697C>T p.R233* 10:87957915-87957915 3
17 COSM5219 PTEN cervix,NS,carcinoma,adenocarcinoma c.388C>G p.R130G 10:87933147-87933147 3
18 COSM5056 PTEN cervix,NS,carcinoma,adenocarcinoma c.1093G>A p.V365I 10:87965353-87965353 3
19 COSM5152 PTEN cervix,NS,carcinoma,adenocarcinoma c.388C>T p.R130* 10:87933147-87933147 3
20 COSM88109 PTEN cervix,NS,carcinoma,adenocarcinoma c.724G>T p.E242* 10:87957942-87957942 3
21 COSM2927185 PPP2R1A cervix,NS,carcinoma,clear cell carcinoma c.770G>T p.W257L 19:52213073-52213073 3
22 COSM6951151 PIK3R1 cervix,NS,carcinoma,clear cell carcinoma c.2069C>T p.S690F 5:68297495-68297495 3
23 COSM27133 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1633G>C p.E545Q 3:179218303-179218303 3
24 COSM6147 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1636C>G p.Q546E 3:179218306-179218306 3
25 COSM763 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1633G>A p.E545K 3:179218303-179218303 3
26 COSM29313 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.3129G>A p.M1043I 3:179234286-179234286 3
27 COSM760 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1624G>A p.E542K 3:179218294-179218294 3
28 COSM24712 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1638G>T p.Q546H 3:179218308-179218308 3
29 COSM775 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.3140A>G p.H1047R 3:179234297-179234297 3
30 COSM759 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1616C>G p.P539R 3:179218286-179218286 3
31 COSM12584 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1357G>A p.E453K 3:179210291-179210291 3
32 COSM746 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.263G>A p.R88Q 3:179199088-179199088 3
33 COSM584 NRAS cervix,NS,carcinoma,adenocarcinoma c.182A>G p.Q61R 1:114713908-114713908 3
34 COSM6951154 MAX cervix,NS,carcinoma,clear cell carcinoma c.280C>G p.L94V 14:65077928-65077928 3
35 COSM521 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>A p.G12D 12:25245350-25245350 3
36 COSM522 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>C p.G12A 12:25245350-25245350 3
37 COSM517 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>A p.G12S 12:25245351-25245351 3
38 COSM532 KRAS cervix,NS,carcinoma,adenocarcinoma c.38G>A p.G13D 12:25245347-25245347 3
39 COSM516 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>T p.G12C 12:25245351-25245351 3
40 COSM520 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>T p.G12V 12:25245350-25245350 3
41 COSM551 KRAS cervix,NS,carcinoma,adenocarcinoma c.182A>C p.Q61P 12:25227342-25227342 3
42 COSM555 KRAS cervix,NS,carcinoma,adenocarcinoma c.183A>T p.Q61H 12:25227341-25227341 3
43 COSM518 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>C p.G12R 12:25245351-25245351 3
44 COSM546 KRAS cervix,NS,carcinoma,adenocarcinoma c.175G>A p.A59T 12:25227349-25227349 3
45 COSM96324 KEAP1 cervix,NS,carcinoma,adenocarcinoma c.778C>T p.R260* 19:10492124-10492124 3
46 COSM480 HRAS cervix,NS,carcinoma,adenocarcinoma c.34G>A p.G12S 11:534289-534289 3
47 COSM5945795 GNA11 cervix,NS,carcinoma,adenocarcinoma c.972C>G p.I324M 19:3121071-3121071 3
48 COSM420169 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1436G>C p.R479P 4:152326214-152326214 3
49 COSM22932 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1393C>T p.R465C 4:152328233-152328233 3
50 COSM22975 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1513C>T p.R505C 4:152326137-152326137 3

Expression for Cervical Clear Cell Adenocarcinoma

Search GEO for disease gene expression data for Cervical Clear Cell Adenocarcinoma.

Pathways for Cervical Clear Cell Adenocarcinoma

Pathways related to Cervical Clear Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.14 NCAM1 KRT8 KRT7 KRT5 KRT19 KRT18
2 12.04 KRT8 KRT7 KRT5 KRT19 KRT18
3
Show member pathways
11.89 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14
4 11.61 NCAM1 KITLG GP5
5
Show member pathways
11.13 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14
6 10.98 KRT8 KRT19 ESR1

GO Terms for Cervical Clear Cell Adenocarcinoma

Cellular components related to Cervical Clear Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 NAPSA KRT8 KRT7 KRT5 KRT19 KRT18
2 cell periphery GO:0071944 9.46 KRT8 KRT19 KRT18 KRT14
3 dystrophin-associated glycoprotein complex GO:0016010 9.43 KRT8 KRT19
4 costamere GO:0043034 9.4 KRT8 KRT19
5 apicolateral plasma membrane GO:0016327 9.37 KRT8 KRT19
6 keratin filament GO:0045095 9.35 KRT8 KRT7 KRT5 KRT18 KRT14
7 intermediate filament GO:0005882 9.1 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14
8 cytosol GO:0005829 10.1 PGR NCAM1 MAPK8IP1 KRT8 KRT7 KRT5

Biological processes related to Cervical Clear Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.65 NCAM1 KRT8 KRT7 KRT19 KRT18
2 keratinization GO:0031424 9.43 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14
3 hemidesmosome assembly GO:0031581 9.37 KRT5 KRT14
4 hepatocyte apoptotic process GO:0097284 9.32 KRT8 KRT18
5 cell differentiation involved in embryonic placenta development GO:0060706 9.16 KRT8 KRT19
6 cornification GO:0070268 9.1 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14

Molecular functions related to Cervical Clear Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.13 KRT5 KRT19 KRT14
2 scaffold protein binding GO:0097110 8.8 KRT8 KRT5 KRT18

Sources for Cervical Clear Cell Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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44 MeSH
45 MESH via Orphanet
46 MGI
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50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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