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MCID: CRV043
MIFTS: 44

Cervical Dystonia

Categories: Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cervical Dystonia

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MalaCards integrated aliases for Cervical Dystonia:

Name: Cervical Dystonia 12 54 38 15
Spasmodic Torticollis 12 77 54

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:0050840
KEGG 38 H01608
ICD10 34 G24.3
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Summaries for Cervical Dystonia

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NIH Rare Diseases : 54 Cervical dystoniais a neurological condition characterized by excessive pulling of the muscles of the neck and shoulder resulting in abnormal movements of the head (dystonia). Most commonly, the head turns to one side or the other. Tilting sideways, or to the back or front may also occur. The turning or tilting movements may be accompanied by shaking movement (tremor) and/or soreness of the muscles of the neck and shoulders. Cervical dystonia can occur at any age, but most cases occur in middle age. It often begins slowly and usually reaches a plateau over a few months or years. The cause of cervical dystonia is often unknown. In some cases there is a family history. Several genes have been associated with cervical dystonia, including GNAL, THAP1, CIZ1, and ANO3. Other cases may be linked to an underlying disease (e.g. Parkinson disease), neck trauma, or certain medications. Treatment may include local injections of botulinum toxin, pain medications, benzodiazepines (anti-anxiety medications), anticholinergics, physical therapy, or surgery.

MalaCards based summary : Cervical Dystonia, also known as spasmodic torticollis, is related to dystonia 24 and dystonia 11, myoclonic. An important gene associated with Cervical Dystonia is CIZ1 (CDKN1A Interacting Zinc Finger Protein 1), and among its related pathways/superpathways are ICos-ICosL Pathway in T-Helper Cell and Tuberculosis. The drugs Acetylcholine and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cerebellum.

Disease Ontology : 12 A focal dystonia that is characterized by simultaneous contraction of the agonist and antagonist muscles that control the position of the head contracting during dystonic movement which causes the neck to involuntarily turn to the left, right, upwards, and/or downwards.

Wikipedia : 77 Spasmodic torticollis is an extremely painful chronic neurological movement disorder causing the neck to... more...

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Related Diseases for Cervical Dystonia

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Diseases related to Cervical Dystonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 dystonia 24 32.1 THAP1 TOR1A
2 dystonia 11, myoclonic 31.2 CAMP GCH1 THAP1 TOR1A
3 torticollis 30.8 CIZ1 TOR1A
4 dystonia 30.7 CIZ1 DRD5 GCH1 GNAL THAP1 TOR1A
5 spasmodic dysphonia 30.1 THAP1 TOR1A
6 blepharospasm 29.3 CAMP DRD5 GCH1 GNAL THAP1 TOR1A
7 dystonia 12 29.3 CAMP GCH1 THAP1 TOR1A
8 focal hand dystonia 29.0 CAMP DRD5 THAP1 TOR1A
9 spasmodic dystonia 28.9 CAMP GNAL THAP1 TOR1A
10 focal dystonia 27.7 CAMP CDIP1 CIZ1 DRD5 GNAL THAP1
11 dystonia 23 11.7
12 torticollis, familial 11.7
13 leukoencephalopathy with dystonia and motor neuropathy 11.5
14 dyt-gnal 11.5
15 lymphatic malformation 5 11.4
16 x-linked dystonia-parkinsonism/lubag 11.2
17 dystonia 7, torsion 11.1
18 torsion dystonia 4 11.1
19 dyt-thap1 11.1
20 dyt-tubb4a 11.1
21 benign paroxysmal torticollis of infancy 10.4
22 tremor 10.4
23 beryllium disease 10.2 HLA-DQA1 HLA-DRB1
24 hirata disease 10.2 HLA-DQA1 HLA-DRB1
25 alexithymia 10.2
26 social phobia 10.2
27 neuropathy 10.2
28 eosinophilia-myalgia syndrome 10.2 HLA-DQA1 HLA-DRB1
29 autosomal dominant cerebellar ataxia 10.2
30 essential tremor 10.2
31 sympathetic ophthalmia 10.2 HLA-DQA1 HLA-DRB1
32 idiopathic bronchiectasis 10.2 HLA-DQA1 HLA-DRB1
33 histoplasmosis 10.2 HLA-DQA1 HLA-DRB1
34 acute disseminated encephalomyelitis 10.2 HLA-DQA1 HLA-DRB1
35 oligoarticular juvenile idiopathic arthritis 10.1 HLA-DQA1 HLA-DRB1
36 dysphagia 10.1
37 headache 10.1
38 hemifacial spasm 10.1
39 tardive dyskinesia 10.1
40 thrombosis 10.1
41 thoracic outlet syndrome 10.1
42 neurotic disorder 10.1
43 acquired immunodeficiency syndrome 10.1
44 narcolepsy 10.1
45 athetosis 10.1
46 cytomegalovirus infection 10.1
47 head injury 10.1
48 autoimmune disease of gastrointestinal tract 10.1 HLA-DQA1 TOR1A
49 thiamine metabolism dysfunction syndrome 2 10.1 GCH1 TOR1A
50 focal epithelial hyperplasia 10.0 HLA-DQA1 HLA-DRB1

Graphical network of the top 20 diseases related to Cervical Dystonia:



Diseases related to Cervical Dystonia
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Symptoms & Phenotypes for Cervical Dystonia

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Drugs & Therapeutics for Cervical Dystonia

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Drugs for Cervical Dystonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-84-3 187
2 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
3 abobotulinumtoxinA Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
4 Botulinum Toxins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
5 Neuromuscular Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
6 Acetylcholine Release Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
7 Cholinergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
8 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
9 Botulinum Toxins, Type A Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
10 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
11 rimabotulinumtoxinB Phase 4,Phase 2
12 incobotulinumtoxinA Phase 4,Phase 3,Phase 2
13
Propranolol Approved, Investigational Phase 2, Phase 3 525-66-6 4946
14 Anti-Arrhythmia Agents Phase 2, Phase 3
15 Adrenergic beta-Antagonists Phase 2, Phase 3
16 Adrenergic Antagonists Phase 2, Phase 3
17 Vasodilator Agents Phase 2, Phase 3
18 Antihypertensive Agents Phase 2, Phase 3
19 Adrenergic Agents Phase 2, Phase 3
20
Dronabinol Approved, Illicit Phase 2 1972-08-3 16078
21
Etanercept Approved, Investigational Phase 1, Phase 2 185243-69-0
22
Levetiracetam Approved, Investigational Phase 2 102767-28-2 441341
23
Amlodipine Approved Phase 2 88150-42-9 2162
24
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
25 Hallucinogens Phase 2
26 Hormones Phase 2
27 Psychotropic Drugs Phase 2
28 Cannabinoid Receptor Agonists Phase 2
29 Analgesics Phase 2,Phase 1
30 Hormone Antagonists Phase 2
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
32 Analgesics, Non-Narcotic Phase 2,Phase 1
33 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
34 Immunosuppressive Agents Phase 1, Phase 2
35 Anti-Inflammatory Agents Phase 1, Phase 2,Not Applicable
36 Immunologic Factors Phase 1, Phase 2
37 Antirheumatic Agents Phase 1, Phase 2
38 Gastrointestinal Agents Phase 1, Phase 2
39 Autoantibodies Phase 1, Phase 2
40 Nootropic Agents Phase 2
41 Anticonvulsants Phase 2
42 Calcium, Dietary Phase 2
43 calcium channel blockers Phase 2
44
Triamcinolone Approved, Vet_approved Not Applicable 124-94-7 31307
45
Trihexyphenidyl Approved 58947-95-8, 144-11-6 5572
46
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
47
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
48
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
49
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
50
Prednisolone hemisuccinate Experimental Not Applicable 2920-86-7

Interventional clinical trials:

(show top 50) (show all 107)
# Name Status NCT ID Phase Drugs
1 The Impact of Botulinum Toxin Treatment in Quality of Life of Cervical Dystonia Patients Unknown status NCT01664013 Phase 4 Nuronox
2 Botox for Cervical Dystonia Following EMG Mapping Completed NCT00773253 Phase 4 Botulinum toxin A
3 A Study to Compare Dysport® and Botox® in the Treatment of Cervical Dystonia Completed NCT00950664 Phase 4 Dysport® (abobotulinumtoxinA);Botox® (onabotulinumtoxinA)
4 An Open Label Safety and Immunogenicity Study of MYOBLOC (Neurobloc; Botulinum Toxin Type B) Injectable Solution in Patients With Cervical Dystonia Completed NCT00702754 Phase 4
5 Open-Label Non-Inferiority Study Evaluating the Efficacy and Safety of Xeomin® in Subjects With Cervical Dystonia Flex Completed NCT01486264 Phase 4
6 Daily Dystonia Practice - A Trial to Investigate NT 201, the Duration of Treatment Effect After One Injection Session and in Long-term Treatment in Cervical Dystonia Completed NCT00541905 Phase 4 NT 201
7 Efficacy and Safety of Meditoxin® Injection for Cervical Dystonia in Adults With Cerebral Palsy Completed NCT01860196 Phase 4 Meditoxin;Normal saline
8 Neurotoxin and Physical Therapy Completed NCT02177617 Phase 4 Botox injection
9 Effect of Botulinum Toxin Type A on Swallowing in Patients With Cervical Dystonia Completed NCT01384214 Phase 4
10 Efficacy and Safety of Two Different Botulinum Toxin Type A Treatments for Moderate to Severe Cervical Dystonia Terminated NCT00432341 Phase 4
11 Comparison of Efficacy and Safety of Two Different Types of Botulinum Toxin Type A in Moderate to Severe Cervical Dystonia Completed NCT00528541 Phase 4
12 Functional Effects of Botox on the Brain Using MRS and fMRI Completed NCT03373162 Phase 4 onabotulinumtoxinA
13 Frontalis Botulinum Toxin Not yet recruiting NCT03186001 Phase 4 Abobotulinum toxin A
14 OnabotulinumtoxinA in the Management of Psychogenic Dystonia Completed NCT02618889 Phase 4
15 Evaluation of Botulinum Toxin Injection Efficacy in the Treatment of Head Essential Tremor Unknown status NCT02555982 Phase 3 BOTOX ® 200 Unités;Placebo
16 Single Treatment of DaxibotulinumtoxinA for Injection in Adults With Isolated Cervical Dystonia (ASPEN-1) Recruiting NCT03608397 Phase 3
17 Study to Assess the Efficacy and Safety of Dysport® in Cervical Dystonia Completed NCT00447772 Phase 3 Botulinum type A toxin (Dysport®)
18 Efficacy and Safety of DYSPORT® Using 2mL Dilution in Adults With Cervical Dystonia. Completed NCT01753310 Phase 3 Dysport®;Placebo
19 Abobotulinum Toxin and Neubotulinum Toxin Injection in Cerivical Dystonia Not yet recruiting NCT03805152 Phase 3 Neuronox(R);Dysport (R)
20 Study Comparing Short Term Efficacy of Dysport® and Dysport RU® to Placebo, and to Assess Efficacy and Safety of Dysport RU® of Subjects With Cervical Dystonia Completed NCT01261611 Phase 3 Botulinum type A toxin (Dysport RU®);Botulinum type A toxin (Dysport®);Placebo
21 Double-blind, Multicenter Study to Assess the Efficacy of Bilateral Pallidal Stimulation in Patients With Medically Refractory Primary Cervical Dystonia Completed NCT00148889 Phase 3
22 Long Term Safety And Effectiveness Of Dysport® In Adults With Cervical Dystonia Completed NCT01753336 Phase 3 Dysport®
23 Open-label Extension Study of AbobotulinumtoxinA (Dysport®) for the Treatment of Cervical Dystonia Completed NCT00288509 Phase 3 abobotulinumtoxinA (Dysport) 250-1000 units
24 Meditoxin® Treatment in Patients With Cervical Dystonia Completed NCT03232320 Phase 3 Meditoxin;Placebo
25 Long-Term Safety and Efficacy of Repeat Treatments of DaxibotulinumtoxinA for Injection in Adults With Isolated Cervical Dystonia (ASPEN-OLS) Recruiting NCT03617367 Phase 3
26 Randomized, Placebo-Controlled Study of AbobotulinumtoxinA (Dysport®) for the Treatment of Cervical Dystonia Completed NCT00257660 Phase 3 Botulinum type A toxin (Dysport®);Placebo
27 IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Cervical Dystonia Completed NCT00407030 Phase 3 incobotulinumtoxinA (Xeomin) (240 Units);incobotulinumtoxinA (Xeomin) (120 Units);Placebo
28 Effects of Botulinum Toxin Injections in Patients With Hereditary Spastic Paraplegia Completed NCT02604186 Phase 2, Phase 3
29 Addressing Involuntary Movements in Tardive Dyskinesia Completed NCT02291861 Phase 3 SD-809;Placebo
30 Aim to Reduce Movements in Tardive Dyskinesia Completed NCT02195700 Phase 2, Phase 3 SD-809;Placebo
31 Safety and Efficacy of Propranolol in the Treatment of Tardive Dyskinesia Withdrawn NCT03254186 Phase 2, Phase 3 Propranolol Hydrochloride;Placebo Oral Tablet
32 ASIS for Botox in Cervical Dystonia Unknown status NCT02074293 Phase 1, Phase 2 Gadolinium;Gadolinium;Gadolinium;Efficacy of Botox intramuscularly at Week 6;Efficacy of Botox intramuscularly at Week 12;Efficacy of Botox intramuscularly at Week 18;Efficacy of Botox intramuscularly at Week 24;Efficacy of Botox intramuscularly at Week 30;Efficacy of Botox subdermally at Week 6;Efficacy of Botox subdermally at Week 12;Efficacy of Botox subdermally at Week 18;Efficacy of Botox subdermally at Week 24;Efficacy of Botox subdermally at Week 30;Adverse Reactions of Botox intramuscularly;Adverse Reactions of Botox subdermally
33 Efficacy of Dronabinol for the Treatment of Cervical Dystonia Unknown status NCT00418925 Phase 2 Dronabinol
34 Study of the Treatment of Tendinopathy Unruptured of Rotator Cuff by Intramuscular Injection of Botulinum Toxin Unknown status NCT02867787 Phase 2 Botox arm
35 ASIS for Enbrel in Plaque Psoriasis Unknown status NCT02112097 Phase 1, Phase 2 Gadolinium;Gadolinium;Gadolinium;Efficacy of Enbrel subcutaneously at Week 12;Efficacy of Enbrel subcutaneously at Week 24;Efficacy of Enbrel subcutaneously at Week 36;Efficacy of Enbrel subdermally at Week 12;Efficacy of Enbrel subdermally at Week 24;Efficacy of Enbrel subdermally at Week 36;PASI 75 n(%) subcutaneously at Week 12;PASI 75 n(%) subcutaneously at Week 24;PASI 75 n(%) subcutaneously at Week 36;PASI 75 n(%) subdermally at Week 12;PASI 75 n(%) subdermally at Week 24;PASI 75 n(%) subdermally at Week 36;Adverse Reactions of Enbrel subcutaneously;Adverse Reactions of Enbrel subdermally at Week 36;Gadolinium;Gadolinium;Gadolinium
36 Clinical and Kinematic Assessment for Determination of Botox® Injection Parameters in Cervical Dystonia Recruiting NCT02662530 Phase 2 Botulinum Toxin Type A
37 Safety and Tolerability of Perampanel in Cervical Dystonia Recruiting NCT02131467 Phase 1, Phase 2 Perampanel
38 Keppra for Cervical Dystonia Terminated NCT00760318 Phase 2 Keppra
39 Study to Evaluate Safety, Efficacy of Botulinum Toxin Type A in Patients With Cervical Dystonia Completed NCT00564681 Phase 2 Normal Saline
40 Botulinum Toxin Type A (Botox) for the Treatment of Cervical Dystonia and Upper Thoracic Muscular Pain Completed NCT00178945 Phase 1, Phase 2 Botulinum Toxin Type A
41 Randomized, Double-Blind, Placebo-Controlled, Parallel, Group Dose-Response, Study of E2014 in Patients WIth Spasmodic Torticollis Completed NCT00165776 Phase 2 BOTULINUM TOXIN TYPE B
42 Dose-escalating Safety and Preliminary Efficacy of DaxibotulinumtoxinA for Injection in Cervical Dystonia Completed NCT02706795 Phase 2
43 Study for Determine the Safety and Efficacy of Clostridium Botulinum Toxin Type A in Subjects With Cervical Dystonia Completed NCT01588574 Phase 2
44 Amlodipine Plus Botulinum Toxin for Focal Dystonia Completed NCT00015457 Phase 2 Amlodipine plus Botulinum toxin
45 Deep Brain Stimulation for Cervical Dystonia Completed NCT00105430 Phase 2
46 An Electrophysiological Study Of E2014 In Healthy Adult Male Japanese And Caucasian Subjects Completed NCT00280384 Phase 2 E2014 (Botulinum toxin type B);E2014 (Botulinum toxin type B) Placebo
47 Botulinum Toxin Injection Efficiency Unknown status NCT01041157 Phase 1
48 PurTox (Botulinum Toxin Type A) for the Treatment of Adult Onset Spasmodic Torticollis/Cervical Dystonia Completed NCT00549341 Phase 1 Mentor Purified Toxin, Botulinum Toxn Type A, Purified Neurotoxin
49 Deep Brain Stimulation to Treat Cervical Dystonia Completed NCT00132340 Phase 1
50 A Multicenter Pilot Study of Pallidal Deep Brain Stimulation for Cervical Dystonia Unknown status NCT00132990 Not Applicable

Search NIH Clinical Center for Cervical Dystonia

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Genetic Tests for Cervical Dystonia

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Anatomical Context for Cervical Dystonia

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MalaCards organs/tissues related to Cervical Dystonia:

42
Brain, Testes, Cerebellum, Globus Pallidus, Cortex, Spinal Cord, T Cells
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Publications for Cervical Dystonia

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Articles related to Cervical Dystonia:

(show top 50) (show all 1066)
# Title Authors Year
1
Evaluation of anxiety and depression scales and quality of LIFE in cervical dystonia patients on botulinum toxin therapy and their relatives. ( 30659417 )
2019
2
Cervical dystonia in a case of longstanding secondary progressive multiple sclerosis. ( 30612702 )
2019
3
The role of pallidum in the neural integrator model of cervical dystonia. ( 30677494 )
2019
4
Abnormal cerebellar connectivity and plasticity in isolated cervical dystonia. ( 30682155 )
2019
5
The effect of CT-guided botulinum toxin injection on cervical dystonia, confirmed by nine-month follow-up using 18F-FDG PET/CT : A case report. ( 30741760 )
2019
6
Long-term specialized physical therapy in cervical dystonia: outcomes of a randomized controlled trial. ( 30796919 )
2019
7
A randomized study of botulinum toxin versus botulinum toxin plus physical therapy for treatment of cervical dystonia. ( 30837195 )
2019
8
Brachial Neuritis After Botulinum Toxin Injections for Cervical Dystonia: A Need for a Reappraisal? ( 30838316 )
2019
9
A Novel Missense OPA1 Mutation in a Patient with Dominant Optic Atrophy and Cervical Dystonia. ( 30838318 )
2019
10
Secondary Cervical Dystonia and Titubatory Head Tremor. ( 30838321 )
2019
11
Management of cervical dystonia with botulinum neurotoxins and EMG/ultrasound guidance. ( 30859009 )
2019
12
Neural Correlates of Abnormal Temporal Discrimination in Unaffected Relatives of Cervical Dystonia Patients. ( 30914929 )
2019
13
Microvascular decompression with partial occipital condylectomy in a case of pediatric spasmodic torticollis. ( 30701298 )
2019
14
INTEREST IN CD2, a global patient-centred study of long-term cervical dystonia treatment with botulinum toxin. ( 29270685 )
2018
15
Sensory Trick in a Patient with Cervical Dystonia: Insights from Magnetoencephalography. ( 29565281 )
2018
16
Pedunculopontine Nucleus Cholinergic Deficiency in Cervical Dystonia. ( 29508906 )
2018
17
Speech induced cervical dystonia: An unusual task specific dystonia. ( 29174183 )
2018
18
The effects of a relaxation program featuring aquatic therapy and autogenic training among people with cervical dystonia (a pilot study). ( 29939827 )
2018
19
A 500A U/2A mL dilution of abobotulinumtoxinA vs. placebo: randomized study in cervical dystonia. ( 29343142 )
2018
20
Abnormal cerebellar processing of the neck proprioceptive information drives dysfunctions in cervical dystonia. ( 29396401 )
2018
21
Measurement & Analysis of the Temporal Discrimination Threshold Applied to Cervical Dystonia. ( 29443021 )
2018
22
GABA<sub>A</sub> Receptor Availability Changes Underlie Symptoms in Isolated Cervical Dystonia. ( 29670567 )
2018
23
The premotor syndrome of cervical dystonia: Disordered processing of salient environmental stimuli. ( 29205495 )
2018
24
Personalized botulinum toxin type A therapy for cervical dystonia based on kinematic guidance. ( 29557988 )
2018
25
Long-term quality of life in cervical dystonia after treatment with abobotulinum toxin A: a 2-year prospective study. ( 29731634 )
2018
26
Physiological effects of subthalamic nucleus deep brain stimulation surgery in cervical dystonia. ( 29326293 )
2018
27
High prevalence of olfactory dysfunction in cervical dystonia. ( 29724603 )
2018
28
Postural control and the relation with cervical sensorimotor control in patients with idiopathic adult-onset cervical dystonia. ( 29340715 )
2018
29
The effects of a laser-guided postural reeducation program on pain, neck active range of motion, and functional improvement in a 75-year-old patient with cervical dystonia. ( 29939800 )
2018
30
Sonographic Guide for Botulinum Toxin Injections of the Neck Muscles in Cervical Dystonia. ( 29173657 )
2018
31
Changes in sensorimotor network activation after botulinum toxin type A injections in patients with cervical dystonia: a functional MRI study. ( 29971454 )
2018
32
Is perception of visual verticality intact in patients with idiopathic cervical dystonia? ( 29101737 )
2018
33
Cervical dystonia and substance abuse. ( 29569175 )
2018
34
Botulinum Toxin Type A Injection for Cervical Dystonia in Adults with Dyskinetic Cerebral Palsy. ( 29772695 )
2018
35
Cortical modulation of brainstem circuits is abnormal in cervical dystonia. ( 29704573 )
2018
36
Adverse events with botulinum toxin treatment in cervical dystonia: How much should we blame placebo? ( 29910156 )
2018
37
Randomised controlled trial of escitalopram for cervical dystonia with dystonic jerks/tremor. ( 29326295 )
2018
38
Pilot Study of a Device to Induce the Hanger Reflex in Patients with Cervical Dystonia. ( 29607887 )
2018
39
Relationships between Serotonin Transporter Binding in the Raphe Nuclei, Basal Ganglia, and Hippocampus with Clinical Symptoms in Cervical Dystonia: A [<sup>11</sup>C]DASB Positron Emission Tomography Study. ( 29541052 )
2018
40
Oropharyngeal dysphagia in adults with dyskinetic cerebral palsy and cervical dystonia: a preliminary study. ( 29958905 )
2018
41
Sertraline induced cervical dystonia in a patient of Obsessive Compulsive Disorder. ( 29447992 )
2018
42
Sexual dysfunction in cervical dystonia and blepharospasm. ( 30464469 )
2018
43
Quetiapine-induced cervical dystonia. ( 26635371 )
2018
44
Motor Cortical Plasticity Relates to Symptom Severity and Clinical Benefit From Deep Brain Stimulation in Cervical Dystonia. ( 28961350 )
2018
45
Selective Cervical Denervation for Cervical Dystonia: Modification of the Bertrand Procedure. ( 29106650 )
2018
46
Spectrum of practice in the routine management of cervical dystonia with abobotulinumtoxinA: findings from three prospective open-label observational studies. ( 30002865 )
2018
47
Injectable DaxibotulinumtoxinA in Cervical Dystonia: A Phase 2 Dose-Escalation Multicenter Study. ( 30009213 )
2018
48
Cervical dystonia: Normal auditory mismatch negativity and abnormal somatosensory mismatch negativity. ( 30015084 )
2018
49
'Author's Response to Letter to the Editor On 'Ultrasound-Guided Botulinum Toxin Injections in Cervical Dystonia Needs Prompt Muscle Selection, Appropriate Dosage and Precise Guidance'. ( 30096053 )
2018
50
Cervical Dystonia and Executive Function: A Pilot Magnetoencephalography Study. ( 30135369 )
2018
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Variations for Cervical Dystonia

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Expression for Cervical Dystonia

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Search GEO for disease gene expression data for Cervical Dystonia.
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Pathways for Cervical Dystonia

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Pathways related to Cervical Dystonia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
ICos-ICosL Pathway in T-Helper Cell 65
Show member pathways
 11.81 GNAL HLA-DQA1 HLA-DRB1
2
Tuberculosis 38
11.38 CAMP HLA-DQA1 HLA-DRB1
3
DNA damage_Role of Brca1 and Brca2 in DNA repair 23
10.93 GNAL HLA-DQA1 HLA-DRB1
4
CTLA4 Signaling 65
10.65 GNAL HLA-DQA1 HLA-DRB1
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GO Terms for Cervical Dystonia

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Cellular components related to Cervical Dystonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transport vesicle membrane GO:0030658 9.26 HLA-DQA1 HLA-DRB1
2 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DQA1 HLA-DRB1
3 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQA1 HLA-DRB1
4 MHC class II protein complex GO:0042613 8.62 HLA-DQA1 HLA-DRB1

Biological processes related to Cervical Dystonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antigen processing and presentation GO:0019882 9.26 HLA-DQA1 HLA-DRB1
2 negative regulation of blood pressure GO:0045776 9.16 DRD5 GCH1
3 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 8.96 HLA-DQA1 HLA-DRB1
4 regulation of protein localization to cell surface GO:2000008 8.62 BDNF TOR1A

Molecular functions related to Cervical Dystonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-DQA1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.62 HLA-DQA1 HLA-DRB1
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Sources for Cervical Dystonia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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