MCID: CRV025
MIFTS: 38

Cervical Incompetence

Categories: Reproductive diseases

Aliases & Classifications for Cervical Incompetence

MalaCards integrated aliases for Cervical Incompetence:

Name: Cervical Incompetence 12 15
Uterine Cervical Incompetence 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9681
ICD10 33 N88.3
ICD9CM 35 622.5
MeSH 44 D002581
NCIt 50 C50607
SNOMED-CT 68 17382005 36836005
UMLS 73 C0007871

Summaries for Cervical Incompetence

Disease Ontology : 12 A cervix disease that is characterized by the beginning of dilation and effacement of a pregnant woman's cervix before her pregnancy has reached term.

MalaCards based summary : Cervical Incompetence, also known as uterine cervical incompetence, is related to ehlers-danlos syndrome and cervix disease. An important gene associated with Cervical Incompetence is IL6 (Interleukin 6), and among its related pathways/superpathways are Collagen chain trimerization and Degradation of the extracellular matrix. The drugs Misoprostol and Dinoprostone have been mentioned in the context of this disorder. Affiliated tissues include cervix, testes and placenta, and related phenotypes are growth/size/body region and cardiovascular system

Related Diseases for Cervical Incompetence

Diseases related to Cervical Incompetence via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 ehlers-danlos syndrome 29.4 COL5A2 PLOD1
2 cervix disease 11.2
3 osteogenesis imperfecta, type viii 10.0 CRTAP P3H1
4 infertility 10.0
5 dentinogenesis imperfecta 10.0 CRTAP P3H1
6 osteogenesis imperfecta, type ii 10.0 CRTAP P3H1
7 osteogenesis imperfecta, type iii 10.0 CRTAP P3H1
8 bone development disease 9.9 CRTAP P3H1
9 brittle bone disorder 9.9 CRTAP P3H1
10 connective tissue disease 9.9 IL6 P3H1 PLOD1
11 bruck syndrome 9.9 CRTAP P3H1 PLOD1
12 collagen disease 9.9 COL5A2 IL6 PLOD1
13 ectopic pregnancy 9.8
14 appendicitis 9.8
15 hemometra 9.8

Graphical network of the top 20 diseases related to Cervical Incompetence:



Diseases related to Cervical Incompetence

Symptoms & Phenotypes for Cervical Incompetence

MGI Mouse Phenotypes related to Cervical Incompetence:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.8 COL5A2 CRTAP HOXA13 IL6 P3H1 ZMPSTE24
2 cardiovascular system MP:0005385 9.77 COL5A2 HOXA13 IL6 PLOD1 ZMPSTE24
3 integument MP:0010771 9.73 COL5A2 HOXA13 IL6 P3H1 PLOD1 ZMPSTE24
4 limbs/digits/tail MP:0005371 9.46 HOXA13 P3H1 PLOD1 ZMPSTE24
5 muscle MP:0005369 9.26 IL6 P3H1 PLOD1 ZMPSTE24
6 skeleton MP:0005390 9.17 COL5A2 CRTAP HOXA13 IL6 P3H1 PLOD1

Drugs & Therapeutics for Cervical Incompetence

Drugs for Cervical Incompetence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Misoprostol Approved Phase 4,Phase 3 59122-46-2 5282381
2
Dinoprostone Approved Phase 4 363-24-6 5280360
3
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
4
Chloroprocaine Approved Phase 4 133-16-4 8612
5
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
6
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
7 Antacids Phase 4,Phase 3
8 Anti-Ulcer Agents Phase 4,Phase 3
9 Gastrointestinal Agents Phase 4,Phase 3
10 Oxytocics Phase 4,Phase 3
11 Peripheral Nervous System Agents Phase 4,Not Applicable
12 Analgesics Phase 4,Not Applicable
13 Anesthetics, Local Phase 4,Not Applicable
14 Central Nervous System Depressants Phase 4,Not Applicable
15 Anesthetics Phase 4,Not Applicable
16 Analgesics, Opioid Phase 4,Not Applicable
17 Adjuvants, Anesthesia Phase 4,Not Applicable
18 Pharmaceutical Solutions Phase 4
19 Anesthetics, Intravenous Phase 4,Not Applicable
20 Narcotics Phase 4,Not Applicable
21 Anesthetics, General Phase 4,Not Applicable
22
Mifepristone Approved, Investigational Phase 3 84371-65-3 55245
23
Progesterone Approved, Vet_approved Phase 2, Phase 3,Phase 3,Not Applicable 57-83-0 5994
24 Contraceptives, Oral Phase 3
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
26 Contraceptives, Postcoital Phase 3
27 Contraceptive Agents Phase 3
28 Luteolytic Agents Phase 3
29 Hormones Phase 3,Phase 2,Not Applicable
30 Hormone Antagonists Phase 3,Phase 2,Not Applicable
31 Progestins Phase 2, Phase 3,Phase 3,Not Applicable
32
Indomethacin Approved, Investigational Not Applicable 53-86-1 3715
33
Clindamycin Approved, Vet_approved Not Applicable 18323-44-9 29029
34
Cefazolin Approved Not Applicable 25953-19-9 656510 33255
35
Acetylcysteine Approved, Investigational Not Applicable 616-91-1 12035
36
Sevoflurane Approved, Vet_approved Not Applicable 28523-86-6 5206
37
Ropivacaine Approved Not Applicable 84057-95-4 175805 71273
38
Propofol Approved, Investigational, Vet_approved Not Applicable 2078-54-8 4943
39
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
40 Anti-Infective Agents Not Applicable
41 Analgesics, Non-Narcotic Not Applicable
42 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
43 Clindamycin palmitate Not Applicable
44 Anti-Inflammatory Agents Not Applicable
45 Clindamycin phosphate Not Applicable
46 Cyclooxygenase Inhibitors Not Applicable
47 Antirheumatic Agents Not Applicable
48 Antibiotics, Antitubercular Not Applicable
49 Anti-Bacterial Agents Not Applicable
50 Tocolytic Agents Not Applicable

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Intravaginal Misoprostol Versus Dinoprostone Before Diagnostik Hysteroscopy Unknown status NCT01620814 Phase 4 Dinoprostone;misoprostol;control
2 Intrathecal Chloroprocaine vs. Bupivacaine for Cervical Cerclage Recruiting NCT03305575 Phase 4 Chloroprocaine;Bupivacaine
3 Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal) Recruiting NCT02862912 Phase 4 Chloroprocaine;Bupivacaine;Fentanyl;Saline
4 Cervical Preparation for Surgical Abortion at 12-14 Weeks: a Prospective, Randomized, Evaluator-blinded, Multicenter, Controlled Comparison Between Mifepristone, Misoprostol and Their Combination Unknown status NCT01795599 Phase 3 Mifegyne ®;Gymiso®
5 Cerclage for Twins With Short Cervix Withdrawn NCT03077633 Phase 2, Phase 3 Vaginal Progesterone
6 Physical Examination-Indicated Pessary Withdrawn NCT02967445 Phase 3
7 Vaginal Progesterone in Twins With Short Cervix Withdrawn NCT01812239 Phase 2, Phase 3 Vaginal Progesterone gel.;Placebo gel
8 The Effect of Adjunctive Use of Vaginal Progesterone After Cerclage on Prevention of 2nd Trimester Miscarriage Recruiting NCT02846909 Phase 2 Progesterone
9 Patient Attitudes Toward Ultrasound Measurement of Cervical Length Unknown status NCT01482039 Not Applicable
10 Preventing Preterm Birth With a Pessary Unknown status NCT01380158 Not Applicable
11 Multifactorial Approach to Emergent Cerclage Completed NCT01114516 Not Applicable Indomethacin and antibiotics (cefazolin or clindamycin)
12 Dilapan-S Osmotic Dilator in Pre-induction of Labor Completed NCT02098382
13 N-Acetyl Cysteine After Cervical Cerclage Completed NCT00787813 Not Applicable N-Acetyl Cysteine;Placebo
14 The Biomarker Study Completed NCT01148654
15 Amniotic Fluid Sludge in Cerclage Patients as an Indicator for Increased Risk of Preterm Delivery and Neonatal Outcome. Completed NCT00722085
16 Maternal Gut Microbiome (MGM) Study of Diet, the Gut Microbiome and Preterm Birth Completed NCT02560246
17 Cerclage vs Cervical Pessary in Women With Cervical Incompetence Recruiting NCT02405455 Not Applicable
18 Use of Pessary in Case of Cervical Insufficiency and Short Cervix Recruiting NCT03096691 Not Applicable
19 Comparison of Anesthesia Type in Patients Undergoing Transabdominal Cervico Isthmic Cerclage (TCIC) Recruiting NCT03636048 Not Applicable Bupivacaine Hcl 0.5% Inj;Propofol 10 milligram/ML
20 Prolene Versus Ethibond for Cervical Cerclage Recruiting NCT03311867 Not Applicable
21 CellulaR Injury and Preterm Birth Recruiting NCT02441335
22 Prevention of Preterm Birth in Singletons Using Pessary After Resolutive Threatened Preterm Labor Recruiting NCT02484820 Not Applicable
23 The Impact of Cervical Cerclage or Vaginal Progesterone on Vaginal Microbiome Distribution Recruiting NCT03253016 Not Applicable
24 Cervical Occlusion for the Prevention of Preterm Birth Terminated NCT01737788 Not Applicable
25 Determination of ED90 of Intrathecal Lidocaine for Adequate Anesthesia for Elective Cervical Cerclage Surgery Terminated NCT02574832 Not Applicable Lidocaine Administration

Search NIH Clinical Center for Cervical Incompetence

Cochrane evidence based reviews: uterine cervical incompetence

Genetic Tests for Cervical Incompetence

Anatomical Context for Cervical Incompetence

MalaCards organs/tissues related to Cervical Incompetence:

41
Cervix, Testes, Placenta, Bone

Publications for Cervical Incompetence

Articles related to Cervical Incompetence:

(show top 50) (show all 162)
# Title Authors Year
1
Don't be short-sighted: cervical incompetence in a pregnant patient with acute appendicitis. ( 29414522 )
2018
2
The place for prophylactic cerclage in the infertile patient with established cervical incompetence who conceived twins after septum reduction. ( 29209482 )
2017
3
Co-morbidity of cervical incompetence with polycystic ovarian syndrome (PCOS) negatively impacts prognosis: A retrospective analysis of 178 patients. ( 27733131 )
2016
4
EP18.11: Prenatal diagnosis of caput succedaneum associated with cervical incompetence at 16 weeks. ( 27647484 )
2016
5
Role of Cervical Cerclage and Vaginal Progesterone in the Treatment of Cervical Incompetence with/without Preterm Birth History. ( 27823998 )
2016
6
Laparoscopic Cerclage for Prevention of Recurrent Pregnancy Loss Due to Cervical Incompetence. ( 27679035 )
2015
7
Successful delivery after transabdominal cerclage of uterine cervix for cervical incompetence after radical trachelectomy. ( 25944172 )
2015
8
Successful treatment of cervical incompetence using a modified laparoscopic cervical cerclage technique: a cohort study. ( 24965992 )
2014
9
Oxidative status shifts in uterine cervical incompetence patients. ( 24304328 )
2014
10
Effects of Maternal Cervical Incompetence on Morbidity and Mortality of Preterm Neonates with Birth weight Less than 2000g. ( 26019783 )
2014
11
Use of cervical cerclage as a treatment option for cervical incompetence: patient characteristics, presentation and management over a 9 year period in a Kenyan centre. ( 24069746 )
2013
12
Effective treatment of cervical incompetence in a monochorionic monoamniotic twin pregnancy with a rescue cervical cerclage and pessary--a case report and review of literature. ( 23488300 )
2012
13
Cervical incompetence associated with congenital uterine malformations. ( 23700889 )
2012
14
Cervical funneling after cerclage in cervical incompetence as a predictor of pregnancy outcome. ( 21463213 )
2012
15
Pregnancy outcome after cerclage for cervical incompetence at the University of Port Harcourt Teaching Hospital, Port Harcourt. ( 23437511 )
2012
16
Laparoscopic cervicoisthmic cerclage for the treatment of cervical incompetence: case reports. ( 22519240 )
2011
17
Effects of maternal cervical incompetence on morbidity and mortality of very low birthweight neonates. ( 20234141 )
2010
18
Pessary use for the treatment of cervical incompetence and prevention of preterm labour. ( 20334532 )
2010
19
Ambispective study on Mac Donald suturing in pregnant ladies with cervical incompetence in Dhulikhel Hospital. ( 22610738 )
2010
20
Association of very high Hungarian rate of preterm births with cervical incompetence in pregnant women. ( 20586224 )
2010
21
Uterine Didelphys with Pregnancy and Cervical Incompetence. ( 27407898 )
2006
22
Noninvasive cerclage for the management of cervical incompetence: a prospective study. ( 16222537 )
2006
23
A five century evolution of cervical incompetence as a clinical entity. ( 15777226 )
2005
24
Laparoscopic cervico-uterine cerclage using polypropylene mesh for the treatment of cervical incompetence. ( 16026416 )
2005
25
Management of cervical incompetence in Aba, south-eastern Nigeria. ( 16353700 )
2005
26
Cervical incompetence and the role of emergency cerclage. ( 15937588 )
2005
27
Preterm deliveries among women with MacDonald cerclage performed due to cervical incompetence. ( 15192297 )
2004
28
Interleukin-6, but not relaxin, predicts outcome of rescue cerclage in women with cervical incompetence. ( 15467541 )
2004
29
Controversies regarding cervical incompetence, short cervix, and the need for cerclage. ( 15519424 )
2004
30
Cervical surveillance as an alternative to elective cervical cerclage for pregnancy management of suspected cervical incompetence. ( 15191447 )
2004
31
Cervical incompetence prevention randomized cerclage trial: emergency cerclage with bed rest versus bed rest alone. ( 14586323 )
2003
32
Elective and emergency transabdominal cervicoisthmic cerclage for cervical incompetence. ( 12971139 )
2003
33
Diagnostic features of cervical incompetence among women in Maiduguri. ( 12745553 )
2003
34
Complications of cervical cerclage in women with cervical incompetence. ( 14643041 )
2003
35
Vaginal sonography and cervical incompetence. ( 12592276 )
2003
36
Cervical Incompetence Prevention Randomized Cerclage Trial (CIPRACT): effect of therapeutic cerclage with bed rest vs. bed rest only on cervical length. ( 12153667 )
2002
37
Cervical incompetence: a reappraisal of an obstetric controversy. ( 12140372 )
2002
38
The value of transvaginal ultrasonography in diagnosis and management of cervical incompetence. ( 11838756 )
2001
39
Final results of the Cervical Incompetence Prevention Randomized Cerclage Trial (CIPRACT): therapeutic cerclage with bed rest versus bed rest alone. ( 11717642 )
2001
40
Cervical incompetence: the use of selective and emergency cerclage. ( 11234614 )
2001
41
Cervical incompetence: the use of transvaginal sonography to provide an objective diagnosis. ( 11555448 )
2001
42
Hematometra after thermal balloon endometrial ablation in a patient with cervical incompetence. ( 11642669 )
2001
43
Cervical incompetence prevention randomized cerclage trial (CIPRACT): study design and preliminary results. ( 11035320 )
2000
44
Can examination of the cervix provide useful information for prediction of cervical incompetence and following preterm labour? ( 10554937 )
1999
45
MRI appearance of cervical incompetence in a pregnant patient. ( 10576725 )
1999
46
The epidemiology of cervical incompetence in Ramathibodi Hospital between 1982-1997. ( 10511780 )
1999
47
Cervical incompetence: elective, emergent, or urgent cerclage. ( 10454663 )
1999
48
Diagnostic imaging in cervical incompetence. ( 10191659 )
1998
49
The natural history of a positive response to transfundal pressure in women at risk for cervical incompetence. ( 9077619 )
1997
50
Transvaginal ultrasound in the management of women with suspected cervical incompetence. ( 9091023 )
1997

Variations for Cervical Incompetence

Expression for Cervical Incompetence

Search GEO for disease gene expression data for Cervical Incompetence.

Pathways for Cervical Incompetence

GO Terms for Cervical Incompetence

Cellular components related to Cervical Incompetence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.33 CRTAP P3H1 ZMPSTE24
2 endoplasmic reticulum GO:0005783 9.26 CRTAP P3H1 PLOD1 ZMPSTE24
3 endoplasmic reticulum lumen GO:0005788 8.92 COL5A2 CRTAP IL6 P3H1

Biological processes related to Cervical Incompetence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 9.32 PLOD1 ZMPSTE24
2 collagen fibril organization GO:0030199 9.26 COL5A2 PLOD1
3 chaperone-mediated protein folding GO:0061077 9.16 CRTAP P3H1
4 collagen metabolic process GO:0032963 8.96 P3H1 PLOD1
5 negative regulation of post-translational protein modification GO:1901874 8.62 CRTAP P3H1

Molecular functions related to Cervical Incompetence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.26 P3H1 PLOD1
2 dioxygenase activity GO:0051213 9.16 P3H1 PLOD1
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 8.96 P3H1 PLOD1
4 L-ascorbic acid binding GO:0031418 8.62 P3H1 PLOD1

Sources for Cervical Incompetence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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