MCID: CRV025
MIFTS: 34

Cervical Incompetence

Categories: Reproductive diseases

Aliases & Classifications for Cervical Incompetence

MalaCards integrated aliases for Cervical Incompetence:

Name: Cervical Incompetence 12 15 17
Uterine Cervical Incompetence 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:9681
ICD9CM 34 622.5
MeSH 43 D002581
NCIt 49 C50607
SNOMED-CT 67 17382005
ICD10 32 N88.3
UMLS 71 C0007871

Summaries for Cervical Incompetence

Disease Ontology : 12 A cervix disease that is characterized by the beginning of dilation and effacement of a pregnant woman's cervix before her pregnancy has reached term.

MalaCards based summary : Cervical Incompetence, also known as uterine cervical incompetence, is related to cervix disease and placenta disease. An important gene associated with Cervical Incompetence is IL6 (Interleukin 6), and among its related pathways/superpathways are Articular Cartilage Extracellular Matrix and Mesenchymal Stem Cells and Lineage-specific Markers. The drugs Bupivacaine and Prilocaine have been mentioned in the context of this disorder. Affiliated tissues include cervix, uterus and testes, and related phenotype is homeostasis/metabolism.

Related Diseases for Cervical Incompetence

Diseases related to Cervical Incompetence via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 cervix disease 32.0 PTPRN MAPK8IP1 INSM1
2 placenta disease 30.0 SPTB PNLIP OXT IL6
3 vaginal discharge 29.9 SPTB OXT MAPK8IP1 IL6
4 hemometra 29.5 PTPRN MFN2 MAPK8IP1 INSM1
5 preterm premature rupture of the membranes 29.1 SPTB PNLIP OXT IL6 FN1
6 pre-eclampsia 29.0 OXT IL6 FN1 DCN
7 placenta praevia 10.3 SPTB OXT
8 asphyxia neonatorum 10.3 OXT IL6
9 chorioamnionitis 10.3
10 meconium aspiration syndrome 10.3 OXT IL6
11 papillary squamous carcinoma 10.3 MAPK8IP1 INSM1
12 late congenital syphilis 10.2 PNLIP OXT
13 vaginal cancer 10.2 MAPK8IP1 INSM1
14 microinvasive cervical squamous cell carcinoma 10.2 PTPRN INSM1
15 alexithymia 10.2 OXT IL6
16 bleeding disorder, platelet-type, 17 10.2 PTPRN INSM1
17 fallopian tube endometrioid adenocarcinoma 10.2 PTPRN INSM1
18 fallopian tube disease 10.2 MFN2 IL6
19 endometrial disease 10.2 OXT MFN2 IL6
20 endocervical carcinoma 10.2 MAPK8IP1 INSM1
21 funisitis 10.1 SPTB PNLIP IL6
22 rare diabetes mellitus type 2 10.1 MAPK8IP1 IL6
23 infertility 10.1
24 peyronie's disease 10.1 IL6 DCN
25 exudative vitreoretinopathy 1 10.0
26 polycystic ovary syndrome 10.0
27 acute cystitis 10.0
28 placental abruption 10.0
29 bronchopulmonary dysplasia 10.0
30 bicornuate uterus 10.0
31 isthmus cancer 10.0 PTPRN MAPK8IP1 INSM1
32 lymphocele 10.0 PTPRN MAPK8IP1 INSM1
33 uterus carcinoma in situ 10.0 PTPRN MAPK8IP1 INSM1
34 cervix uteri carcinoma in situ 10.0 PTPRN MAPK8IP1 INSM1
35 cervix carcinoma 10.0 PTPRN MAPK8IP1 INSM1
36 recurrent corneal erosion 9.9 IL6 FN1
37 spherocytosis, type 5 9.9 IL6 FN1
38 decubitus ulcer 9.9 IL6 FN1
39 vitreous disease 9.9 IL6 FN1
40 impetigo 9.9 IL6 FN1
41 pelvic organ prolapse 9.9
42 enterocolitis 9.9
43 patent ductus arteriosus 1 9.9
44 ectopic pregnancy 9.9
45 hyperandrogenism 9.9
46 gestational diabetes 9.9
47 periventricular leukomalacia 9.9
48 severe pre-eclampsia 9.9
49 hellp syndrome 9.9
50 ehlers-danlos syndrome 9.9

Graphical network of the top 20 diseases related to Cervical Incompetence:



Diseases related to Cervical Incompetence

Symptoms & Phenotypes for Cervical Incompetence

MGI Mouse Phenotypes related to Cervical Incompetence:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.32 DCN FN1 IL6 INSM1 MAPK8IP1 MFN2

Drugs & Therapeutics for Cervical Incompetence

Drugs for Cervical Incompetence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
2
Prilocaine Approved Phase 4 721-50-6 4906
3
Chloroprocaine Approved Phase 4 133-16-4 8612
4
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
5 Pharmaceutical Solutions Phase 4
6 Anesthetics Phase 4
7 Anesthetics, Local Phase 4
8
Misoprostol Approved Phase 3 59122-46-2 5282381
9 Anti-Ulcer Agents Phase 3
10 Antacids Phase 3
11 Gastrointestinal Agents Phase 3
12 Acidophilus Phase 1
13
Cefazolin Approved 25953-19-9 656510 33255
14
Indomethacin Approved, Investigational 53-86-1 3715
15
Clindamycin Approved, Vet_approved 18323-44-9 29029
16
Nifedipine Approved 21829-25-4 4485
17
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
18
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
19
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
20
Ropivacaine Approved 84057-95-4 71273 175805
21
Sevoflurane Approved, Vet_approved 28523-86-6 5206
22
Lidocaine Approved, Vet_approved 137-58-6 3676
23 Anti-Infective Agents
24 Clindamycin phosphate
25 Analgesics, Non-Narcotic
26 Anti-Bacterial Agents
27 Cyclooxygenase Inhibitors
28 Clindamycin palmitate
29 Antibiotics, Antitubercular
30 Tocolytic Agents
31 Anti-Inflammatory Agents
32 Antirheumatic Agents
33 Anti-Inflammatory Agents, Non-Steroidal
34 Hypnotics and Sedatives
35 Analgesics
36 Anesthetics, General
37 Anesthetics, Intravenous
38 Narcotics
39 Analgesics, Opioid
40 Sodium Channel Blockers
41 Anti-Arrhythmia Agents
42 Diuretics, Potassium Sparing

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 A Randomized Controlled Clinical Trial of Intrathecal Chloroprocaine vs. Bupivacaine for Cervical Cerclage Completed NCT03305575 Phase 4 Chloroprocaine;Bupivacaine
2 Chloroprocaine Versus Bupivacaine Spinal Anesthesia for Cervical Cerclage Completed NCT02862912 Phase 4 Chloroprocaine;Bupivacaine;Fentanyl;Saline
3 Does Subarachnoid Administration of Hyperbaric Prilocaine Produce an Improved Recovery From Anaesthesia When Compared With Hyperbaric Bupivacaine When Used to Make Cervical Cerclage Easier in Pregnant Women at Risk of Pre-term Loss? Not yet recruiting NCT04394533 Phase 4 Prilocaine (Hyperbaric 2%);Bupivacaine (Hyperbaric 0.5%)
4 Determining the ED90 for Intrathecal 3% Chloroprocaine for Elective Cervical Cerclage Surgery Suspended NCT03805438 Phase 4 Chloroprocaine Hcl 3% Inj
5 Misoprostol for Cervical Preparation Prior to Operative Hysteroscopy: Randomized and Quadruple Blind Clinical Trial Comparing 200μg and 800μg Recruiting NCT04152317 Phase 3 Misoprostol 200mcg Tab;Misoprostol 800mcg Tab
6 "Comparison of Vaginal Progesterone With Arabin Cervical Pessary and Vaginal Progesterone Alone in the Prevention of Preterm Delivery in Singleton Pregnancies With Incidental Premature Shortening of Cervical Length" Terminated NCT03052270 Phase 3 Arabin Pessary
7 Cervical Cerclage for Twin Pregnancy With Sonographic Cervical Length 0.1 to 15.0 mm: A Randomized Clinical Trial Withdrawn NCT03077633 Phase 2, Phase 3 Vaginal Progesterone
8 Physical Examination-Indicated Pessary Withdrawn NCT02967445 Phase 3
9 The Effect of Adjunctive Use of Vaginal Progesterone After Cerclage on Prevention of 2nd Trimester Miscarriage Completed NCT02846909 Phase 2 Progesterone
10 Feasibility, Safety, Tolerance and Assessment of LACTIN-V Use in a Cohort of Pregnant Women at Risk of Preterm Birth Recruiting NCT03992534 Phase 1
11 Use of Pessary in Case of Cervical Insufficiency and Short Cervix Unknown status NCT03096691
12 Patient Attitudes Regarding Abdominal Versus Transvaginal Ultrasonography for Assessment of the Cervical Length in Low Risk Patients: a Randomized Trial Unknown status NCT01482039
13 Preventing Preterm Birth With a Pessary Unknown status NCT01380158
14 Amniotic Fluid Sludge in Cerclage Patients as an Indicator for Increased Risk of Preterm Delivery and Neonatal Outcome. Completed NCT00722085
15 Prolene Versus Ethibond for Cervical Cerclage Completed NCT03311867
16 Prospective Collection of Data About the Use of the Dilapan-S Osmotic Dilator in Pre-induction of Labor in Women With/Without Caesarean Section in Their History Completed NCT02098382
17 Role in Emergent Cerclage of Indomethacin and Antibiotics Completed NCT01114516 Indomethacin and antibiotics (cefazolin or clindamycin)
18 Effect of Hysteroscopic Septum Resection on Preterm Birth Rate in Singleton Pregnancies After Primary Infertility Treatment Completed NCT04098289
19 Maternal Serum Level of ACTH as a Predictive Marker of Preterm Labor in Patients With Threatened Preterm Labor Completed NCT01773135
20 Cervical Stiffness Measurement in Cervical Insufficiency Recruiting NCT04158401
21 Cervical Cerclage for Singleton Pregnant on Vaginal Progesterone With Progressive Cervical Length Shortening Recruiting NCT03837288
22 Cerclage vs Cervical Pessary in Women With Cervical Incompetence Recruiting NCT02405455
23 Comparison of General Anesthesia and Combined Spinal-epidural Anesthesia on Postoperative Outcomes in Patients Undergoing Transabdominal Cervico Isthmic Cerclage (TCIC) Recruiting NCT03636048 Bupivacaine Hcl 0.5% Inj;Propofol 10 milligram/ML
24 PREMAPESSAIRE: Prevention of Preterm Birth in Singletons Using Pessary After Resolutive Threatened Preterm Labor: a Prospective, Randomized Monocentric Clinical Trial Recruiting NCT02484820
25 Cervical Cerclage Position Throughout Pregnancy, it`s Distance From the Inner and Outer Cervical os`, and Implications of the Position on Pregnancy Outcomes. Recruiting NCT03046654
26 Randomised Trial of Cervical Cerclage With and Without Occlusion for the Prevention of Preterm Birth in Women Suspected for Cervical Insufficiency Terminated NCT01737788
27 Determination of ED90 of Intrathecal Lidocaine for Adequate Anesthesia for Elective Cervical Cerclage Surgery Terminated NCT02574832 Lidocaine Administration

Search NIH Clinical Center for Cervical Incompetence

Cochrane evidence based reviews: uterine cervical incompetence

Genetic Tests for Cervical Incompetence

Anatomical Context for Cervical Incompetence

MalaCards organs/tissues related to Cervical Incompetence:

40
Cervix, Uterus, Testes, Brain, Colon, Placenta, B Cells

Publications for Cervical Incompetence

Articles related to Cervical Incompetence:

(show top 50) (show all 581)
# Title Authors PMID Year
1
Management of pregnancy after fertility-sparing surgery for cervical cancer. 61
32416616 2020
2
Fertility and Endocrine Preservation in the Management of Colorectal Cancer in Women. 61
32384402 2020
3
A ten year review of time interval between elective cervical cerclage removal at term and spontaneous onset of labour in Enugu, South-East Nigeria. 61
32500771 2020
4
Changes in the perinatal outcomes of twin pregnancies delivered at a tertiary referral center in Korea during a 24-year period from 1995 to 2018. 61
32489969 2020
5
Transabdominal cerclage (TAC) as a new tool for the treatment of cervical incompetence (CI). 61
32566598 2020
6
Removal of an Abdominal Cerclage by Colpotomy: a Novel and Minimally Invasive Technique. 61
32474172 2020
7
McDonald versus modified Shirodkar rescue cerclage in women with prolapsed fetal membranes. 61
30122099 2020
8
Successful heterotopic pregnancy with prior radical trachelectomy after transabdominal cervico isthimic cerclage with methotrexate treatment. 61
32028544 2020
9
Non-typeable Haemophilus influenzae-associated early pregnancy loss: an emerging neonatal and maternal pathogen. 61
31549360 2020
10
The impact of hymenectomy on future gynecological and obstetrical outcomes. 61
30173591 2020
11
An update on uterine cervix pathologies related to infertility. 61
32228872 2020
12
Intrapartum cervical lacerations and their impact on future pregnancy outcome. 61
30189764 2020
13
Are women with cervical incompetence at a higher risk of experiencing urinary and pelvic organ prolapse symptoms? 61
31123796 2020
14
Pregnancy-preserving Laparoendoscopic Single-site Surgery for Gynecologic Disease: A Case Series. 61
32126300 2020
15
Diagnosis and treatment of cervical incompetence combined with intrauterine adhesions. 61
32175348 2020
16
Conservative management of uterine adenosarcoma: lessons learned from 20 years of follow-up. 61
31584132 2019
17
Short-term outcomes of extremely preterm infants at discharge: a multicenter study from Guangdong province during 2008-2017. 61
31685004 2019
18
The efficacy of cervical cerclage combined with a pessary for the prevention of spontaneous preterm birth. 61
31630580 2019
19
Laparoscopic Transabdominal Cerclage for Cervical Incompetence: A Feasible and Effective Treatment in 10 Steps. 61
31678560 2019
20
Analysis of risk factors and predictors of pregnancy loss and strategies for the management of cervical insufficiency in pregnant women at a high risk of preterm birth. 61
31409178 2019
21
Combined therapy with vaginal progesterone, Arabin cervical pessary and cervical cerclage to prevent preterm delivery in high-risk women. 61
31438741 2019
22
Reproductive outcomes after surgical treatment of asherman syndrome: A systematic review. 61
30713131 2019
23
Modified laparoscopic cervicoisthmic cerclage in early pregnancy for refractory cervical incompetence: A case report. 61
31137082 2019
24
Early Onset Intrahepatic Cholestasis of Pregnancy: Is Progesterone Supplementation to be Blamed For? 61
30956477 2019
25
Perinatal outcome of twin pregnancies according to maternal age. 61
30918877 2019
26
Arabin cervical pessary with vaginal progesterone versus vaginal progesterone for preventing preterm delivery. 61
30669913 2019
27
No. 373-Cervical Insufficiency and Cervical Cerclage. 61
30638557 2019
28
No 373 - Insuffisance cervicale et cerclage cervical. 61
30638558 2019
29
Robotic assisted laparoscopic cerclage: A systematic review. 61
30315678 2019
30
Transvaginal cervicoisthmic cerclage for patients with extremely high-risk history of preterm delivery. 61
30191633 2019
31
Don't be short-sighted: cervical incompetence in a pregnant patient with acute appendicitis. 61
29414522 2018
32
[Relationship between inflammatory indexes of amniotic fluid and pregnancy outcome of women with cervical incompetence]. 61
30138960 2018
33
Laparoscopic Transabdominal Cervical Cerclage by Broad Ligament Window Technique. 61
30254959 2018
34
The role of three-dimensional ultrasound in pregnancies submitted to cerclage. 61
30365664 2018
35
A comparison of pregnancy outcome of modified transvaginal cervicoisthmic cerclage performed prior to and during pregnancy. 61
29302808 2018
36
Customized Pessary Fabrication Using Three-Dimensional Printing Technology. 61
29420400 2018
37
Simultaneous pregnancy in each uterine cavity of a double uterus in a young Nigerian multipara who presented with a retained second twin following an unsupervised preterm labor at home; Case report. 61
29275238 2018
38
Transabdominal cerclage (TAC) for patients with ultra-short uterine cervix after uterine cervix surgery and its impact on pregnancy. 61
29121417 2018
39
Effects of cervical cerclage on cervical length and the impact of changes in cervical length on pregnancy prognosis. 61
30848137 2018
40
The problem of miscarriage in multiple pregnancy. 61
30448784 2018
41
Bicornuate uterus is an independent risk factor for cervical os insufficiency: A retrospective population based cohort study. 61
27903074 2017
42
The influence of ovulation induction and assisted conception on maternal and perinatal outcomes of twin pregnancies. 61
29028104 2017
43
Vaginal progesterone pessaries for pregnant women with a previous preterm birth to prevent neonatal respiratory distress syndrome (the PROGRESS Study): A multicentre, randomised, placebo-controlled trial. 61
28949973 2017
44
Medical conditions associated with recurrent miscarriage-Is BMI the tip of the iceberg? 61
28494269 2017
45
The place for prophylactic cerclage in the infertile patient with established cervical incompetence who conceived twins after septum reduction. 61
29209482 2017
46
Risk Factors and Risk Stratification for Adverse Obstetrical Outcomes After Appendectomy or Cholecystectomy During Pregnancy. 61
28114513 2017
47
Reproductive Outcome of Transcervical Uterine Incision in Unicornuate Uterus. 61
28139506 2017
48
Familial deletion of the HOXA gene cluster associated with Hand-Foot-Genital syndrome and phenotypic variability. 61
27649277 2017
49
Insuffisance cervicale et cerclage cervical. 61
28063549 2016
50
Role of Cervical Cerclage and Vaginal Progesterone in the Treatment of Cervical Incompetence with/without Preterm Birth History. 61
27823998 2016

Variations for Cervical Incompetence

Expression for Cervical Incompetence

Search GEO for disease gene expression data for Cervical Incompetence.

Pathways for Cervical Incompetence

Pathways related to Cervical Incompetence according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.81 FN1 DCN
2 10.78 IL6 FN1 DCN
3 10.69 IL6 DCN
4 10.23 IL6 FN1

GO Terms for Cervical Incompetence

Biological processes related to Cervical Incompetence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 8.96 IL6 FN1
2 endocrine pancreas development GO:0031018 8.62 INSM1 IL6

Sources for Cervical Incompetence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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