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MCID: CRV025
MIFTS: 35

Cervical Incompetence

Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cervical Incompetence

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MalaCards integrated aliases for Cervical Incompetence:

Name: Cervical Incompetence 12 15 17
Uterine Cervical Incompetence 44 70

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:9681
ICD9CM 34 622.5
MeSH 44 D002581
NCIt 50 C50607
SNOMED-CT 67 36836005
ICD10 32 N88.3
UMLS 70 C0007871
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Summaries for Cervical Incompetence

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Disease Ontology : 12 A cervix disease that is characterized by the beginning of dilation and effacement of a pregnant woman's cervix before her pregnancy has reached term.

MalaCards based summary : Cervical Incompetence, also known as uterine cervical incompetence, is related to vaginal discharge and hemometra. An important gene associated with Cervical Incompetence is IL6 (Interleukin 6), and among its related pathways/superpathways are Degradation of the extracellular matrix and Articular Cartilage Extracellular Matrix Pathway. The drugs Bupivacaine and Chloroprocaine have been mentioned in the context of this disorder. Affiliated tissues include cervix, uterus and placenta, and related phenotype is integument.

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Related Diseases for Cervical Incompetence

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Diseases related to Cervical Incompetence via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 vaginal discharge 30.3 PTPRN OXT IL6
2 hemometra 30.2 PTPRN INSM1
3 preterm premature rupture of the membranes 29.9 OXT IL6 FN1 DCN
4 endometritis 29.7 OXT IL6
5 pre-eclampsia 29.6 OXT IL6 FN1 DCN
6 ehlers-danlos syndrome 29.5 PLOD1 FN1 DCN
7 cervix disease 11.1
8 somatization disorder 10.3 OXT IL6
9 neurotic disorder 10.3 OXT IL6
10 asphyxia neonatorum 10.3 OXT IL6
11 acute stress disorder 10.3 OXT IL6
12 funisitis 10.3 OXT IL6
13 chorioamnionitis 10.3
14 isthmus cancer 10.3 PTPRN INSM1
15 microinvasive cervical squamous cell carcinoma 10.3 PTPRN INSM1
16 lymphocele 10.3 PTPRN INSM1
17 bleeding disorder, platelet-type, 17 10.3 PTPRN INSM1
18 fallopian tube endometrioid adenocarcinoma 10.3 PTPRN INSM1
19 benign struma ovarii 10.3 PTPRN INSM1
20 meconium aspiration syndrome 10.2 OXT IL6
21 tendinitis 10.2 IL6 DCN
22 endometrial disease 10.2 OXT IL6
23 uterus carcinoma in situ 10.2 PTPRN INSM1
24 alexithymia 10.2 OXT IL6
25 cervix uteri carcinoma in situ 10.2 PTPRN INSM1
26 peyronie's disease 10.2 IL6 DCN
27 recurrent corneal erosion 10.2 IL6 FN1
28 gingival recession 10.2 IL6 FN1
29 decubitus ulcer 10.1 IL6 FN1
30 parametritis 10.1 PTPRN OXT INSM1
31 spherocytosis, type 5 10.1 IL6 FN1
32 actinomycosis 10.1 IL6 FN1
33 necrotizing fasciitis 10.1 IL6 FN1
34 persistent fetal circulation syndrome 10.1 OXT IL6
35 scleredema adultorum 10.1 FN1 DCN
36 vitreous disease 10.1 IL6 FN1
37 vaginitis 10.1 IL6 FN1
38 placenta disease 10.1
39 chronic ulcer of skin 10.1 IL6 FN1
40 macular holes 10.1 IL6 FN1
41 mesangial proliferative glomerulonephritis 10.1 IL6 FN1
42 brittle cornea syndrome 10.1 PRDM5 PLOD1
43 gingival disease 10.0 IL6 FN1
44 exudative vitreoretinopathy 1 10.0
45 urinary tract infection 10.0
46 polycystic ovary syndrome 10.0
47 infertility 10.0
48 placental abruption 10.0
49 bronchopulmonary dysplasia 10.0
50 bicornuate uterus 10.0

Graphical network of the top 20 diseases related to Cervical Incompetence:



Diseases related to Cervical Incompetence
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Symptoms & Phenotypes for Cervical Incompetence

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MGI Mouse Phenotypes related to Cervical Incompetence:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.17 DCN FN1 IL6 OXT P3H1 PLOD1
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Drugs & Therapeutics for Cervical Incompetence

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Drugs for Cervical Incompetence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
2
Chloroprocaine Approved Phase 4 133-16-4 8612
3
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
4
Prilocaine Approved Phase 4 721-50-6 4906
5 Anesthetics Phase 4
6 Anesthetics, Local Phase 4
7 Anesthetics, General Phase 4
8 Anesthetics, Intravenous Phase 4
9 Analgesics Phase 4
10 Pharmaceutical Solutions Phase 4
11 Narcotics Phase 4
12 Analgesics, Opioid Phase 4
13
Misoprostol Approved Phase 3 59122-46-2 5282381
14 Gastrointestinal Agents Phase 3
15 Antacids Phase 3
16 Anti-Ulcer Agents Phase 3
17 Acidophilus Phase 1
18
Cefazolin Approved 25953-19-9 656510 33255
19
Clindamycin Approved, Vet_approved 18323-44-9 29029
20
Indomethacin Approved, Investigational 53-86-1 3715
21
Ropivacaine Approved 84057-95-4 71273 175805
22
Sevoflurane Approved, Vet_approved 28523-86-6 5206
23
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
24 Antibiotics, Antitubercular
25 Antirheumatic Agents
26 Anti-Bacterial Agents
27 Clindamycin palmitate
28 Clindamycin phosphate
29 Cyclooxygenase Inhibitors
30 Anti-Inflammatory Agents
31 Tocolytic Agents
32 Anti-Infective Agents
33 Anti-Inflammatory Agents, Non-Steroidal
34 Analgesics, Non-Narcotic
35 Hypnotics and Sedatives

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 A Randomized Controlled Clinical Trial of Intrathecal Chloroprocaine vs. Bupivacaine for Cervical Cerclage Completed NCT03305575 Phase 4 Chloroprocaine;Bupivacaine
2 Chloroprocaine Versus Bupivacaine Spinal Anesthesia for Cervical Cerclage Completed NCT02862912 Phase 4 Chloroprocaine;Bupivacaine;Fentanyl;Saline
3 Does Subarachnoid Administration of Hyperbaric Prilocaine Produce an Improved Recovery From Anaesthesia When Compared With Hyperbaric Bupivacaine When Used to Make Cervical Cerclage Easier in Pregnant Women at Risk of Pre-term Loss? Not yet recruiting NCT04394533 Phase 4 Prilocaine (Hyperbaric 2%);Bupivacaine (Hyperbaric 0.5%)
4 Comparison Between 200 μg and 800 μg of Misoprostol for Cervical Ripening Prior to Operative Hysteroscopy: Randomized and Quadruple Blind Clinical Trial. Completed NCT04152317 Phase 3 Misoprostol 200mcg Tab;Misoprostol 800mcg Tab
5 Cervical Cerclage for Twin Pregnancy With Sonographic Cervical Length 0.1 to 15.0 mm: A Randomized Clinical Trial Withdrawn NCT03077633 Phase 2, Phase 3 Vaginal Progesterone
6 Feasibility, Safety, Tolerance and Assessment of LACTIN-V Use in a Cohort of Pregnant Women at Risk of Preterm Birth Recruiting NCT03992534 Phase 1
7 Cervical Cerclage for Singleton Pregnant on Vaginal Progesterone With Progressive Cervical Length Shortening Unknown status NCT03837288
8 Use of Pessary in Case of Cervical Insufficiency and Short Cervix Unknown status NCT03096691
9 Patient Attitudes Regarding Abdominal Versus Transvaginal Ultrasonography for Assessment of the Cervical Length in Low Risk Patients: a Randomized Trial Unknown status NCT01482039
10 Prospective Collection of Data About the Use of the Dilapan-S Osmotic Dilator in Pre-induction of Labor in Women With/Without Caesarean Section in Their History Completed NCT02098382
11 Prolene Versus Ethibond for Cervical Cerclage Completed NCT03311867
12 Amniotic Fluid Sludge in Cerclage Patients as an Indicator for Increased Risk of Preterm Delivery and Neonatal Outcome. Completed NCT00722085
13 Role in Emergent Cerclage of Indomethacin and Antibiotics Completed NCT01114516 Indomethacin and antibiotics (cefazolin or clindamycin)
14 Cerclage vs Cervical Pessary in Women With Cervical Incompetence Completed NCT02405455
15 Cervical Stiffness Measurement in Cervical Insufficiency Recruiting NCT04158401
16 Investigation Into the Fungal Microbiome (Mycobiome) in the Cervices of Cervical Insufficiency Patients Receiving Cerclage Treatment and Resulting in Term or Preterm Birth Recruiting NCT04688866
17 Effectiveness of CERvico-isthmic CErclage in Increasing the Rate of Live Births in Case of a History of Late Miscarriage and/or Premature Delivery Not yet recruiting NCT04722536
18 Randomised Trial of Cervical Cerclage With and Without Occlusion for the Prevention of Preterm Birth in Women Suspected for Cervical Insufficiency Terminated NCT01737788
19 Comparison of General Anesthesia and Combined Spinal-epidural Anesthesia on Postoperative Outcomes in Patients Undergoing Transabdominal Cervico Isthmic Cerclage (TCIC) Terminated NCT03636048 Bupivacaine Hcl 0.5% Inj;Propofol 10 milligram/ML
20 Preventing Preterm Birth With a Pessary Withdrawn NCT01380158

Search NIH Clinical Center for Cervical Incompetence

Cochrane evidence based reviews: uterine cervical incompetence

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Genetic Tests for Cervical Incompetence

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Anatomical Context for Cervical Incompetence

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MalaCards organs/tissues related to Cervical Incompetence:

40
Cervix, Uterus, Placenta, Ovary, Fetal Brain, Bone, Skin
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Publications for Cervical Incompetence

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Articles related to Cervical Incompetence:

(show top 50) (show all 596)
# Title Authors PMID Year
1
The association of chronic endometritis with mid-trimester loss due to cervical incompetence and the outcome of laparoscopic cervical cerclage. 61
33811545 2021
2
Fertility outcomes after preconceptional laparoscopic abdominal cerclage for second-trimester pregnancy losses. 61
33360240 2021
3
A comparison of pregnancy outcome of emergency modified transvaginal cervicoisthmic cerclage performed in twin and singleton pregnancies. 61
33386955 2021
4
The temporal link between prenatal steroid therapy and labor. 61
33387425 2020
5
Minimally Invasive Laparoscopic Transabdominal Cerclage with a "Needle-Free" Technique: A Single-Center Experience. 61
33326965 2020
6
Evaluation of cervical length and optimal timing for pregnancy after cervical conization in patients with cervical intraepithelial neoplasia: A retrospective study. 61
33285731 2020
7
Removal of an Abdominal Cerclage by Colpotomy: A Novel and Minimally Invasive Technique. 61
32474172 2020
8
The prevalence of cervical insufficiency in Chinese women with polycystic ovary syndrome undergone ART treatment accompanied with negative prognosis: a retrospective study. 61
33228414 2020
9
Pregnancy-preserving Laparoendoscopic Single-site Surgery for Gynecologic Disease: A Case Series. 61
32126300 2020
10
Chikungunya infection in pregnancy - reassuring maternal and perinatal outcomes: a retrospective observational study. 61
33040457 2020
11
Arabin cervical pessary with vaginal progesterone versus vaginal progesterone for preventing preterm delivery. 61
30669913 2020
12
[MAVRIC study: when abdominal cerclage is preferable to vaginal cerclage]. 61
33112514 2020
13
[Clinical efficacy of surgical opportunity of the modified transvaginal cervicoisthmic cerclage in treatment of the cervical incompetence]. 61
32993250 2020
14
Anatomical and functional changes in arteries of uterine circulation after modified laparoscopic transabdominal cerclage in pregnancy: A case report and review of the literature. 61
32765735 2020
15
The Conundrum of Prematurity and Pregnancy Outcomes after Fertility Sparing Treatment Modalities for Early Stage Cervical Cancer:  A Systematic Review of the Literature. 61
33009739 2020
16
Management of pregnancy after fertility-sparing surgery for cervical cancer. 61
32416616 2020
17
Pregnancy outcomes in women with Ehlers-Danlos Syndrome. 61
32654548 2020
18
Laparoscopic Transabdominal Cerclage for Cervical Incompetence: A Feasible and Effective Treatment in 10 Steps. 61
31678560 2020
19
Interval Laparoscopic Transabdominal Cervical Cerclage (ILTACC) Using Needleless Mersilene Tape for Cervical Incompetence. 61
33101915 2020
20
A ten year review of time interval between elective cervical cerclage removal at term and spontaneous onset of labour in Enugu, South-East Nigeria. 61
32500771 2020
21
Fertility and Endocrine Preservation in the Management of Colorectal Cancer in Women. 61
32384402 2020
22
Changes in the perinatal outcomes of twin pregnancies delivered at a tertiary referral center in Korea during a 24-year period from 1995 to 2018. 61
32489969 2020
23
Transabdominal cerclage (TAC) as a new tool for the treatment of cervical incompetence (CI). 61
32566598 2020
24
McDonald versus modified Shirodkar rescue cerclage in women with prolapsed fetal membranes. 61
30122099 2020
25
Successful heterotopic pregnancy with prior radical trachelectomy after transabdominal cervico isthimic cerclage with methotrexate treatment. 61
32028544 2020
26
The impact of hymenectomy on future gynecological and obstetrical outcomes. 61
30173591 2020
27
An update on uterine cervix pathologies related to infertility. 61
32228872 2020
28
Non-typeable Haemophilus influenzae-associated early pregnancy loss: an emerging neonatal and maternal pathogen. 61
31549360 2020
29
Intrapartum cervical lacerations and their impact on future pregnancy outcome. 61
30189764 2020
30
Diagnosis and treatment of cervical incompetence combined with intrauterine adhesions. 61
32175348 2020
31
Are women with cervical incompetence at a higher risk of experiencing urinary and pelvic organ prolapse symptoms? 61
31123796 2020
32
Prenatal care for woman after fertility-sparing surgery for cervical cancer. 61
33711903 2020
33
Short-term outcomes of extremely preterm infants at discharge: a multicenter study from Guangdong province during 2008-2017. 61
31685004 2019
34
Conservative management of uterine adenosarcoma: lessons learned from 20 years of follow-up. 61
31584132 2019
35
The efficacy of cervical cerclage combined with a pessary for the prevention of spontaneous preterm birth. 61
31630580 2019
36
Combined therapy with vaginal progesterone, Arabin cervical pessary and cervical cerclage to prevent preterm delivery in high-risk women. 61
31438741 2019
37
Analysis of risk factors and predictors of pregnancy loss and strategies for the management of cervical insufficiency in pregnant women at a high risk of preterm birth. 61
31409178 2019
38
Reproductive outcomes after surgical treatment of asherman syndrome: A systematic review. 61
30713131 2019
39
Modified laparoscopic cervicoisthmic cerclage in early pregnancy for refractory cervical incompetence: A case report. 61
31137082 2019
40
Early Onset Intrahepatic Cholestasis of Pregnancy: Is Progesterone Supplementation to be Blamed For? 61
30956477 2019
41
Perinatal outcome of twin pregnancies according to maternal age. 61
30918877 2019
42
Robotic assisted laparoscopic cerclage: A systematic review. 61
30315678 2019
43
Transvaginal cervicoisthmic cerclage for patients with extremely high-risk history of preterm delivery. 61
30191633 2019
44
No 373 - Insuffisance cervicale et cerclage cervical. 61
30638558 2019
45
No. 373-Cervical Insufficiency and Cervical Cerclage. 61
30638557 2019
46
Don't be short-sighted: cervical incompetence in a pregnant patient with acute appendicitis. 61
29414522 2018
47
[Relationship between inflammatory indexes of amniotic fluid and pregnancy outcome of women with cervical incompetence]. 61
30138960 2018
48
The role of three-dimensional ultrasound in pregnancies submitted to cerclage. 61
30365664 2018
49
Laparoscopic Transabdominal Cervical Cerclage by Broad Ligament Window Technique. 61
30254959 2018
50
A comparison of pregnancy outcome of modified transvaginal cervicoisthmic cerclage performed prior to and during pregnancy. 61
29302808 2018
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Variations for Cervical Incompetence

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Expression for Cervical Incompetence

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Search GEO for disease gene expression data for Cervical Incompetence.
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Pathways for Cervical Incompetence

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Pathways related to Cervical Incompetence according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Degradation of the extracellular matrix 65
Show member pathways
 12.11 PLOD1 P3H1 FN1 DCN
2
Articular Cartilage Extracellular Matrix Pathway 64
10.88 FN1 DCN
3
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
10.79 IL6 DCN
4
Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers 64
10.78 IL6 FN1 DCN
5
Overview of nanoparticle effects 1
10.23 IL6 FN1
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GO Terms for Cervical Incompetence

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Biological processes related to Cervical Incompetence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocrine pancreas development GO:0031018 8.62 INSM1 IL6

Molecular functions related to Cervical Incompetence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 L-ascorbic acid binding GO:0031418 8.96 PLOD1 P3H1
2 collagen binding GO:0005518 8.8 P3H1 FN1 DCN
Sources

Sources for Cervical Incompetence

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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