MCID: CRV025
MIFTS: 38

Cervical Incompetence

Categories: Reproductive diseases

Aliases & Classifications for Cervical Incompetence

MalaCards integrated aliases for Cervical Incompetence:

Name: Cervical Incompetence 12 15 17
Uterine Cervical Incompetence 45 74

Classifications:



External Ids:

Disease Ontology 12 DOID:9681
ICD9CM 36 622.5
MeSH 45 D002581
NCIt 51 C50607
SNOMED-CT 69 17382005 36836005
ICD10 34 N88.3
UMLS 74 C0007871

Summaries for Cervical Incompetence

Disease Ontology : 12 A cervix disease that is characterized by the beginning of dilation and effacement of a pregnant woman's cervix before her pregnancy has reached term.

MalaCards based summary : Cervical Incompetence, also known as uterine cervical incompetence, is related to ehlers-danlos syndrome and cervix disease. An important gene associated with Cervical Incompetence is IL6 (Interleukin 6), and among its related pathways/superpathways are Collagen chain trimerization and Degradation of the extracellular matrix. The drugs Dinoprostone and Misoprostol have been mentioned in the context of this disorder. Affiliated tissues include cervix, bone and testes, and related phenotypes are growth/size/body region and behavior/neurological

Related Diseases for Cervical Incompetence

Graphical network of the top 20 diseases related to Cervical Incompetence:



Diseases related to Cervical Incompetence

Symptoms & Phenotypes for Cervical Incompetence

MGI Mouse Phenotypes related to Cervical Incompetence:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.8 ADAMTS2 COL5A2 CRTAP HOXA2 IL6 P3H1
2 behavior/neurological MP:0005386 9.77 COL5A2 HOXA2 IL6 P3H1 PLOD1
3 integument MP:0010771 9.65 ADAMTS2 COL5A2 IL6 P3H1 PLOD1
4 muscle MP:0005369 9.46 HOXA2 IL6 P3H1 PLOD1
5 respiratory system MP:0005388 9.26 ADAMTS2 COL5A2 HOXA2 IL6
6 skeleton MP:0005390 9.17 ADAMTS2 COL5A2 CRTAP HOXA2 IL6 P3H1

Drugs & Therapeutics for Cervical Incompetence

Drugs for Cervical Incompetence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dinoprostone Approved Phase 4 363-24-6 5280360
2
Misoprostol Approved Phase 4,Phase 3 59122-46-2 5282381
3
Chloroprocaine Approved Phase 4 133-16-4 8612
4
Bupivacaine Approved, Investigational Phase 4,Not Applicable 38396-39-3, 2180-92-9 2474
5
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
6
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
7 Oxytocics Phase 4,Phase 3
8 Anti-Ulcer Agents Phase 4,Phase 3
9 Gastrointestinal Agents Phase 4,Phase 3
10 Antacids Phase 4,Phase 3
11 Central Nervous System Depressants Phase 4,Not Applicable
12 Anesthetics, Local Phase 4,Not Applicable
13 Anesthetics Phase 4,Not Applicable
14 Peripheral Nervous System Agents Phase 4,Not Applicable
15 Analgesics Phase 4,Not Applicable
16 Analgesics, Opioid Phase 4,Not Applicable
17 Anesthetics, General Phase 4,Not Applicable
18 Narcotics Phase 4,Not Applicable
19 Pharmaceutical Solutions Phase 4
20 Adjuvants, Anesthesia Phase 4,Not Applicable
21 Anesthetics, Intravenous Phase 4,Not Applicable
22
Mifepristone Approved, Investigational Phase 3 84371-65-3 55245
23
Progesterone Approved, Vet_approved Phase 2, Phase 3,Phase 3,Not Applicable 57-83-0 5994
24 Hormones Phase 3,Phase 2,Not Applicable
25 Hormone Antagonists Phase 3,Phase 2,Not Applicable
26 Contraceptives, Postcoital Phase 3
27 Contraceptives, Oral Phase 3
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
29 Contraceptive Agents Phase 3
30 Luteolytic Agents Phase 3
31 Progestins Phase 2, Phase 3,Phase 3,Not Applicable
32
Clindamycin Approved, Vet_approved Not Applicable 18323-44-9 29029
33
Cefazolin Approved Not Applicable 25953-19-9 33255 656510
34
Indomethacin Approved, Investigational Not Applicable 53-86-1 3715
35
Acetylcysteine Approved, Investigational Not Applicable 616-91-1 12035
36
Ropivacaine Approved Not Applicable 84057-95-4 175805 71273
37
Sevoflurane Approved, Vet_approved Not Applicable 28523-86-6 5206
38
Propofol Approved, Investigational, Vet_approved Not Applicable 2078-54-8 4943
39
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
40 Cyclooxygenase Inhibitors Not Applicable
41 Anti-Bacterial Agents Not Applicable
42 Antibiotics, Antitubercular Not Applicable
43 Clindamycin palmitate Not Applicable
44 Anti-Infective Agents Not Applicable
45 Analgesics, Non-Narcotic Not Applicable
46 Anti-Inflammatory Agents Not Applicable
47 Antirheumatic Agents Not Applicable
48 Clindamycin phosphate Not Applicable
49 Tocolytic Agents Not Applicable
50 Antitubercular Agents Not Applicable

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Intravaginal Misoprostol Versus Dinoprostone Before Diagnostik Hysteroscopy Unknown status NCT01620814 Phase 4 Dinoprostone;misoprostol;control
2 Intrathecal Chloroprocaine vs. Bupivacaine for Cervical Cerclage Completed NCT03305575 Phase 4 Chloroprocaine;Bupivacaine
3 Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal) Recruiting NCT02862912 Phase 4 Chloroprocaine;Bupivacaine;Fentanyl;Saline
4 Cervical Preparation for Surgical Abortion at 12-14 Weeks: a Prospective, Randomized, Evaluator-blinded, Multicenter, Controlled Comparison Between Mifepristone, Misoprostol and Their Combination Unknown status NCT01795599 Phase 3 Mifegyne ®;Gymiso®
5 Cerclage for Twins With Short Cervix Withdrawn NCT03077633 Phase 2, Phase 3 Vaginal Progesterone
6 Physical Examination-Indicated Pessary Withdrawn NCT02967445 Phase 3
7 Vaginal Progesterone in Twins With Short Cervix Withdrawn NCT01812239 Phase 2, Phase 3 Vaginal Progesterone gel.;Placebo gel
8 The Effect of Adjunctive Use of Vaginal Progesterone After Cerclage on Prevention of 2nd Trimester Miscarriage Unknown status NCT02846909 Phase 2 Progesterone
9 Use of Pessary in Case of Cervical Insufficiency and Short Cervix Unknown status NCT03096691 Not Applicable
10 Patient Attitudes Toward Ultrasound Measurement of Cervical Length Unknown status NCT01482039 Not Applicable
11 Preventing Preterm Birth With a Pessary Unknown status NCT01380158 Not Applicable
12 Multifactorial Approach to Emergent Cerclage Completed NCT01114516 Not Applicable Indomethacin and antibiotics (cefazolin or clindamycin)
13 Dilapan-S Osmotic Dilator in Pre-induction of Labor Completed NCT02098382
14 N-Acetyl Cysteine After Cervical Cerclage Completed NCT00787813 Not Applicable N-Acetyl Cysteine;Placebo
15 The Biomarker Study Completed NCT01148654
16 Amniotic Fluid Sludge in Cerclage Patients as an Indicator for Increased Risk of Preterm Delivery and Neonatal Outcome. Completed NCT00722085
17 Maternal Gut Microbiome (MGM) Study of Diet, the Gut Microbiome and Preterm Birth Completed NCT02560246
18 Cerclage vs Cervical Pessary in Women With Cervical Incompetence Recruiting NCT02405455 Not Applicable
19 Comparison of Anesthesia Type in Patients Undergoing Transabdominal Cervico Isthmic Cerclage (TCIC) Recruiting NCT03636048 Not Applicable Bupivacaine Hcl 0.5% Inj;Propofol 10 milligram/ML
20 Prolene Versus Ethibond for Cervical Cerclage Recruiting NCT03311867 Not Applicable
21 Cervical Cerclage for Singleton Pregnant on Vaginal Progesterone With Progressive Cervical Length Shortening Recruiting NCT03837288 Not Applicable
22 CellulaR Injury and Preterm Birth Recruiting NCT02441335
23 Prevention of Preterm Birth in Singletons Using Pessary After Resolutive Threatened Preterm Labor Recruiting NCT02484820 Not Applicable
24 The Impact of Cervical Cerclage or Vaginal Progesterone on Vaginal Microbiome Distribution Recruiting NCT03253016 Not Applicable
25 Cervical Occlusion for the Prevention of Preterm Birth Terminated NCT01737788 Not Applicable
26 Determination of ED90 of Intrathecal Lidocaine for Adequate Anesthesia for Elective Cervical Cerclage Surgery Terminated NCT02574832 Not Applicable Lidocaine Administration

Search NIH Clinical Center for Cervical Incompetence

Cochrane evidence based reviews: uterine cervical incompetence

Genetic Tests for Cervical Incompetence

Anatomical Context for Cervical Incompetence

MalaCards organs/tissues related to Cervical Incompetence:

42
Cervix, Bone, Testes, Placenta, Ovary

Publications for Cervical Incompetence

Articles related to Cervical Incompetence:

(show top 50) (show all 161)
# Title Authors Year
1
Don't be short-sighted: cervical incompetence in a pregnant patient with acute appendicitis. ( 29414522 )
2018
2
The place for prophylactic cerclage in the infertile patient with established cervical incompetence who conceived twins after septum reduction. ( 29209482 )
2017
3
Co-morbidity of cervical incompetence with polycystic ovarian syndrome (PCOS) negatively impacts prognosis: A retrospective analysis of 178 patients. ( 27733131 )
2016
4
Role of Cervical Cerclage and Vaginal Progesterone in the Treatment of Cervical Incompetence with/without Preterm Birth History. ( 27823998 )
2016
5
Laparoscopic Cerclage for Prevention of Recurrent Pregnancy Loss Due to Cervical Incompetence. ( 27679035 )
2015
6
Successful delivery after transabdominal cerclage of uterine cervix for cervical incompetence after radical trachelectomy. ( 25944172 )
2015
7
Effects of Maternal Cervical Incompetence on Morbidity and Mortality of Preterm Neonates with Birth weight Less than 2000g. ( 26019783 )
2014
8
Successful treatment of cervical incompetence using a modified laparoscopic cervical cerclage technique: a cohort study. ( 24965992 )
2014
9
Oxidative status shifts in uterine cervical incompetence patients. ( 24304328 )
2014
10
Use of cervical cerclage as a treatment option for cervical incompetence: patient characteristics, presentation and management over a 9 year period in a Kenyan centre. ( 24069746 )
2013
11
Cervical incompetence associated with congenital uterine malformations. ( 23700889 )
2012
12
Effective treatment of cervical incompetence in a monochorionic monoamniotic twin pregnancy with a rescue cervical cerclage and pessary--a case report and review of literature. ( 23488300 )
2012
13
Pregnancy outcome after cerclage for cervical incompetence at the University of Port Harcourt Teaching Hospital, Port Harcourt. ( 23437511 )
2012
14
Cervical funneling after cerclage in cervical incompetence as a predictor of pregnancy outcome. ( 21463213 )
2012
15
Laparoscopic cervicoisthmic cerclage for the treatment of cervical incompetence: case reports. ( 22519240 )
2011
16
Ambispective study on Mac Donald suturing in pregnant ladies with cervical incompetence in Dhulikhel Hospital. ( 22610738 )
2010
17
Association of very high Hungarian rate of preterm births with cervical incompetence in pregnant women. ( 20586224 )
2010
18
Pessary use for the treatment of cervical incompetence and prevention of preterm labour. ( 20334532 )
2010
19
Effects of maternal cervical incompetence on morbidity and mortality of very low birthweight neonates. ( 20234141 )
2010
20
Uterine Didelphys with Pregnancy and Cervical Incompetence. ( 27407898 )
2006
21
Noninvasive cerclage for the management of cervical incompetence: a prospective study. ( 16222537 )
2006
22
A five century evolution of cervical incompetence as a clinical entity. ( 15777226 )
2005
23
Management of cervical incompetence in Aba, south-eastern Nigeria. ( 16353700 )
2005
24
Laparoscopic cervico-uterine cerclage using polypropylene mesh for the treatment of cervical incompetence. ( 16026416 )
2005
25
Cervical incompetence and the role of emergency cerclage. ( 15937588 )
2005
26
Cervical surveillance as an alternative to elective cervical cerclage for pregnancy management of suspected cervical incompetence. ( 15191447 )
2004
27
Preterm deliveries among women with MacDonald cerclage performed due to cervical incompetence. ( 15192297 )
2004
28
Interleukin-6, but not relaxin, predicts outcome of rescue cerclage in women with cervical incompetence. ( 15467541 )
2004
29
Controversies regarding cervical incompetence, short cervix, and the need for cerclage. ( 15519424 )
2004
30
Vaginal sonography and cervical incompetence. ( 12592276 )
2003
31
Diagnostic features of cervical incompetence among women in Maiduguri. ( 12745553 )
2003
32
Elective and emergency transabdominal cervicoisthmic cerclage for cervical incompetence. ( 12971139 )
2003
33
Cervical incompetence prevention randomized cerclage trial: emergency cerclage with bed rest versus bed rest alone. ( 14586323 )
2003
34
Complications of cervical cerclage in women with cervical incompetence. ( 14643041 )
2003
35
Cervical incompetence: a reappraisal of an obstetric controversy. ( 12140372 )
2002
36
Cervical Incompetence Prevention Randomized Cerclage Trial (CIPRACT): effect of therapeutic cerclage with bed rest vs. bed rest only on cervical length. ( 12153667 )
2002
37
Cervical incompetence: the use of selective and emergency cerclage. ( 11234614 )
2001
38
Cervical incompetence: the use of transvaginal sonography to provide an objective diagnosis. ( 11555448 )
2001
39
Hematometra after thermal balloon endometrial ablation in a patient with cervical incompetence. ( 11642669 )
2001
40
Final results of the Cervical Incompetence Prevention Randomized Cerclage Trial (CIPRACT): therapeutic cerclage with bed rest versus bed rest alone. ( 11717642 )
2001
41
The value of transvaginal ultrasonography in diagnosis and management of cervical incompetence. ( 11838756 )
2001
42
Cervical incompetence prevention randomized cerclage trial (CIPRACT): study design and preliminary results. ( 11035320 )
2000
43
Cervical incompetence: elective, emergent, or urgent cerclage. ( 10454663 )
1999
44
The epidemiology of cervical incompetence in Ramathibodi Hospital between 1982-1997. ( 10511780 )
1999
45
Can examination of the cervix provide useful information for prediction of cervical incompetence and following preterm labour? ( 10554937 )
1999
46
MRI appearance of cervical incompetence in a pregnant patient. ( 10576725 )
1999
47
Diagnostic imaging in cervical incompetence. ( 10191659 )
1998
48
The natural history of a positive response to transfundal pressure in women at risk for cervical incompetence. ( 9077619 )
1997
49
Transvaginal ultrasound in the management of women with suspected cervical incompetence. ( 9091022 )
1997
50
Transvaginal ultrasound in the management of women with suspected cervical incompetence. ( 9091023 )
1997

Variations for Cervical Incompetence

Expression for Cervical Incompetence

Search GEO for disease gene expression data for Cervical Incompetence.

Pathways for Cervical Incompetence

GO Terms for Cervical Incompetence

Cellular components related to Cervical Incompetence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 8.92 COL5A2 CRTAP IL6 P3H1

Biological processes related to Cervical Incompetence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skin development GO:0043588 9.32 ADAMTS2 COL5A2
2 chaperone-mediated protein folding GO:0061077 9.26 CRTAP P3H1
3 collagen metabolic process GO:0032963 9.16 P3H1 PLOD1
4 collagen fibril organization GO:0030199 9.13 ADAMTS2 COL5A2 PLOD1
5 negative regulation of post-translational protein modification GO:1901874 8.62 CRTAP P3H1

Molecular functions related to Cervical Incompetence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 iron ion binding GO:0005506 9.26 P3H1 PLOD1
2 dioxygenase activity GO:0051213 9.16 P3H1 PLOD1
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 8.96 P3H1 PLOD1
4 L-ascorbic acid binding GO:0031418 8.62 P3H1 PLOD1

Sources for Cervical Incompetence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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