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MCID: CRV025
MIFTS: 34

Cervical Incompetence

Categories: Reproductive diseases
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Aliases & Classifications for Cervical Incompetence

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MalaCards integrated aliases for Cervical Incompetence:

Name: Cervical Incompetence 11 14 16
Uterine Cervical Incompetence 43 71

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 31


External Ids:

Disease Ontology 11 DOID:9681
ICD9CM 34 622.5
MeSH 43 D002581
NCIt 49 C50607
SNOMED-CT 68 36836005
ICD10 31 N88.3
UMLS 71 C0007871
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Summaries for Cervical Incompetence

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Disease Ontology: 11 A cervix disease that is characterized by the beginning of dilation and effacement of a pregnant woman's cervix before her pregnancy has reached term.

MalaCards based summary: Cervical Incompetence, also known as uterine cervical incompetence, is related to exudative vitreoretinopathy 1 and vaginal discharge. An important gene associated with Cervical Incompetence is IL6 (Interleukin 6), and among its related pathways/superpathways are Extracellular matrix organization and ECM proteoglycans. The drugs Chloroprocaine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include cervix, uterus and placenta.
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Related Diseases for Cervical Incompetence

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Diseases related to Cervical Incompetence via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 exudative vitreoretinopathy 1 30.1 IL6 IGFBP1 FN1
2 vaginal discharge 30.0 OXT MAPK8IP1 IL6 IGFBP1
3 gestational diabetes 29.8 PTPRN IL6 IGFBP1
4 hemometra 29.8 PTPRN OXT MAPK8IP1 INSM1
5 pre-eclampsia 29.3 OXT IL6 IGFBP1 FN1 DCN
6 preterm premature rupture of the membranes 29.1 OXT IL6 IGFBP1 FN1 DCN COL5A1
7 ehlers-danlos syndrome 28.6 IGFBP1 FN1 DCN CRTAP COL5A1
8 cervix disease 11.2
9 chorioamnionitis 10.3
10 somatization disorder 10.3 OXT IL6
11 aspiration pneumonitis 10.3 OXT IL6
12 papillary squamous carcinoma 10.3 MAPK8IP1 INSM1
13 funisitis 10.3 OXT IL6
14 melancholia 10.3 OXT IL6
15 parametritis 10.3 PTPRN OXT
16 neurotic disorder 10.3 OXT IL6
17 microinvasive cervical squamous cell carcinoma 10.3 PTPRN INSM1
18 adjustment disorder 10.3 OXT IL6
19 asphyxia neonatorum 10.2 OXT IL6
20 inappropriate adh syndrome 10.2 OXT IL6
21 cervical adenosquamous carcinoma 10.2 PTPRN MAPK8IP1
22 fallopian tube endometrioid adenocarcinoma 10.2 PTPRN INSM1
23 vaginal cancer 10.2 MAPK8IP1 INSM1
24 dysthymic disorder 10.2 OXT IL6
25 gingival recession 10.2 IL6 FN1
26 postpartum depression 10.2 OXT IL6
27 necrotizing fasciitis 10.2 IL6 FN1
28 keratopathy 10.2 IL6 FN1
29 meconium aspiration syndrome 10.2 OXT IL6
30 decubitus ulcer 10.2 IL6 FN1
31 septic arthritis 10.1 IL6 FN1
32 vaginitis 10.1 IL6 FN1
33 isthmus cancer 10.1 PTPRN MAPK8IP1 INSM1
34 lymphocele 10.1 PTPRN MAPK8IP1 INSM1
35 uterus carcinoma in situ 10.1 PTPRN MAPK8IP1 INSM1
36 cervix uteri carcinoma in situ 10.1 PTPRN MAPK8IP1 INSM1
37 adenocarcinoma in situ 10.1 PTPRN MAPK8IP1 INSM1
38 mild pre-eclampsia 10.1 OXT IGFBP1
39 adenosquamous carcinoma 10.1 PTPRN MAPK8IP1 INSM1
40 vaginal disease 10.1 MAPK8IP1 IL6 FN1
41 placental abruption 10.1
42 infective endocarditis 10.1 IL6 FN1
43 endometrial disease 10.1 OXT IL6 IGFBP1
44 cervix carcinoma 10.1 PTPRN MAPK8IP1 INSM1
45 mesangial proliferative glomerulonephritis 10.1 IL6 FN1
46 vitreous disease 10.1 IL6 FN1
47 urinary tract infection 10.0
48 polycystic ovary syndrome 10.0
49 infertility 10.0
50 connective tissue disease 10.0

Graphical network of the top 20 diseases related to Cervical Incompetence:



Diseases related to Cervical Incompetence
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Symptoms & Phenotypes for Cervical Incompetence

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Drugs & Therapeutics for Cervical Incompetence

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Drugs for Cervical Incompetence (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chloroprocaine Approved, Investigational Phase 4 133-16-4 8612
2
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
3
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
4
Azithromycin Approved Phase 4 83905-01-5 447043
5
Cefazolin Approved Phase 4 25953-19-9 33255
6
Prilocaine Approved Phase 4 721-50-6 4906
7
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
8 Anesthetics, Intravenous Phase 4
9 Anesthetics, General Phase 4
10 Pharmaceutical Solutions Phase 4
11 Analgesics, Opioid Phase 4
12 Narcotics Phase 4
13 Anesthetics, Local Phase 4
14 Anesthetics Phase 4
15 Analgesics Phase 4
16 Antirheumatic Agents Phase 4
17 Anti-Bacterial Agents Phase 4
18 Anti-Infective Agents Phase 4
19 Cyclooxygenase Inhibitors Phase 4
20 Anti-Inflammatory Agents, Non-Steroidal Phase 4
21 Analgesics, Non-Narcotic Phase 4
22 Anti-Inflammatory Agents Phase 4
23 Antibiotics, Antitubercular Phase 4
24 Tocolytic Agents Phase 4
25
Misoprostol Approved Phase 3 59122-46-2 5282381
26 Anti-Ulcer Agents Phase 3
27 Antacids Phase 3
28 Gastrointestinal Agents Phase 3
29 Acidophilus Phase 1
30
Clindamycin Approved, Vet_approved 18323-44-9, 24729-96-2 29029
31
Ropivacaine Approved 84057-95-4 71273 175805
32
Sevoflurane Approved, Vet_approved 28523-86-6 5206
33
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
34
Clindamycin phosphate 32603
35 Clindamycin palmitate
36 Hypnotics and Sedatives

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 A Randomized Controlled Clinical Trial of Intrathecal Chloroprocaine vs. Bupivacaine for Cervical Cerclage Completed NCT03305575 Phase 4 Chloroprocaine;Bupivacaine
2 Chloroprocaine Versus Bupivacaine Spinal Anesthesia for Cervical Cerclage Completed NCT02862912 Phase 4 Chloroprocaine;Bupivacaine;Fentanyl;Saline
3 Azithromycin to Improve Latency in Exam Indicated Cerclage: a Randomized Control Trial Recruiting NCT05132829 Phase 4 Azithromycin 1 gram IV;Cefazolin and indomethacin
4 Does Subarachnoid Administration of Hyperbaric Prilocaine Produce an Improved Recovery From Anaesthesia When Compared With Hyperbaric Bupivacaine When Used to Make Cervical Cerclage Easier in Pregnant Women at Risk of Pre-term Loss? Recruiting NCT04394533 Phase 4 Prilocaine (Hyperbaric 2%);Bupivacaine (Hyperbaric 0.5%)
5 Comparison Between 200 μg and 800 μg of Misoprostol for Cervical Ripening Prior to Operative Hysteroscopy: Randomized and Quadruple Blind Clinical Trial. Completed NCT04152317 Phase 3 Misoprostol 200mcg Tab;Misoprostol 800mcg Tab
6 Cervical Cerclage for Twin Pregnancy With Sonographic Cervical Length 0.1 to 15.0 mm: A Randomized Clinical Trial Withdrawn NCT03077633 Phase 2, Phase 3 Vaginal Progesterone
7 Feasibility, Safety, Tolerance and Assessment of LACTIN-V Use in a Cohort of Pregnant Women at Risk of Preterm Birth Unknown status NCT03992534 Phase 1
8 Preventing Preterm Birth With a Negative Pressure Cervical Cup: a Feasibility Study Not yet recruiting NCT05512052 Phase 1
9 Use of Pessary in Case of Cervical Insufficiency and Short Cervix Unknown status NCT03096691
10 Cervical Cerclage for Singleton Pregnant on Vaginal Progesterone With Progressive Cervical Length Shortening Unknown status NCT03837288
11 Patient Attitudes Regarding Abdominal Versus Transvaginal Ultrasonography for Assessment of the Cervical Length in Low Risk Patients: a Randomized Trial Unknown status NCT01482039
12 Amniotic Fluid Sludge in Cerclage Patients as an Indicator for Increased Risk of Preterm Delivery and Neonatal Outcome. Completed NCT00722085
13 Cervical Stiffness Measurement in Cervical Insufficiency Completed NCT04158401
14 Prolene Versus Ethibond for Cervical Cerclage Completed NCT03311867
15 Prospective Collection of Data About the Use of the Dilapan-S Osmotic Dilator in Pre-induction of Labor in Women With/Without Caesarean Section in Their History Completed NCT02098382
16 Effectiveness of CERvico-isthmic CErclage in Increasing the Rate of Live Births in Case of a History of Late Miscarriage and/or Premature Delivery Completed NCT04722536
17 Cerclage vs Cervical Pessary in Women With Cervical Incompetence Completed NCT02405455
18 Role in Emergent Cerclage of Indomethacin and Antibiotics Completed NCT01114516 Indomethacin and antibiotics (cefazolin or clindamycin)
19 Investigation Into the Fungal Microbiome (Mycobiome) in the Cervices of Cervical Insufficiency Patients Receiving Cerclage Treatment and Resulting in Term or Preterm Birth Recruiting NCT04688866
20 Comparison of the Efficacy of Emergency Two-level and Single Cervical Cerclage in Cervical Insufficiency in the Second Trimester of Pregnancy - Multicenter Prospective Randomized Trial Recruiting NCT05268640
21 Is the Cerclage Area Associated With the Incidence of Preterm Birth in Pregnant Women Undergoing Mc Donald Cerclage? Recruiting NCT05220839
22 Assessment of Cervical SofTening and the Prediction of Preterm Birth' Not yet recruiting NCT05477381
23 Comparison of General Anesthesia and Combined Spinal-epidural Anesthesia on Postoperative Outcomes in Patients Undergoing Transabdominal Cervico Isthmic Cerclage (TCIC) Terminated NCT03636048 Bupivacaine Hcl 0.5% Inj;Propofol 10 milligram/ML
24 Randomised Trial of Cervical Cerclage With and Without Occlusion for the Prevention of Preterm Birth in Women Suspected for Cervical Insufficiency Terminated NCT01737788

Search NIH Clinical Center for Cervical Incompetence

Cochrane evidence based reviews: uterine cervical incompetence

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Genetic Tests for Cervical Incompetence

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Anatomical Context for Cervical Incompetence

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Organs/tissues related to Cervical Incompetence:

MalaCards : Cervix, Uterus, Placenta, Fetal Brain, Ovary, Heart, Brain
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Publications for Cervical Incompetence

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Articles related to Cervical Incompetence:

(show top 50) (show all 614)
# Title Authors PMID Year
1
Cerclage in surgically shortened uterine cervix and pregnancy outcome: A retrospective comparison between the abdominal and vaginal procedures. 62
36110090 2022
2
Retrospective analysis of stillbirth and induced termination of pregnancies: Factors affecting determination. 62
35779911 2022
3
Pregnancy outcomes in women with Ehlers-Danlos Syndrome. 62
32654548 2022
4
A retrospective cohort study of obstetric complications and birth outcomes in women with polycystic ovarian syndrome. 62
34392796 2022
5
Effects of vaginal microecology and immunity on the pregnancy outcome of cervical cerclage. 62
35568847 2022
6
Clinical analysis of 2860 cases of diabetes in pregnancy: a single-center retrospective study. 62
35585514 2022
7
A Three-Step Procedure for Emergency Cerclage: Gestational and Neonatal Outcomes. 62
35270320 2022
8
Characterization of cervical canal and vaginal bacteria in pregnant women with cervical incompetence. 62
36246259 2022
9
Effects of vaginal microbiota and cervical cerclage on obstetric outcomes of twin pregnancies with cervical incompetence: a retrospective study. 62
34351473 2022
10
THE CLINICAL ASSESSMENT OF THE CERVICAL PERFORATED PESSARY FOR THE PREVENTION OF PRETERM LABOR IN WOMEN WITH PRIOR PRETERM BIRTHS. 62
35182121 2022
11
The association of chronic endometritis with mid-trimester loss due to cervical incompetence and the outcome of laparoscopic cervical cerclage. 62
33811545 2021
12
[ALGORITHM FOR PREDICTING THE DURATION OF TREATMENT FOR CONGENITAL PNEUMONIA IN PRETERM INFANTS]. 62
34897047 2021
13
Retro cervical tunneling to ensure correct placement for robotic-assisted transabdominal cerclage. 62
34579826 2021
14
Bulging of both membranes and fetal lower limbs: conservative management. 62
33904690 2021
15
Is an abdominal cerclage indicated with a cervical myomectomy? A case report. 62
34354932 2021
16
The prevalence of cervical insufficiency in Chinese women with polycystic ovary syndrome undergone ART treatment accompanied with negative prognosis: a retrospective study. 62
33228414 2021
17
Peripartum cardiomyopathy and acute heart failure associated with prolonged tocolytic therapy in pregnancy: A case report. 62
34449509 2021
18
The efficacy of cervical cerclage combined with a pessary for the prevention of spontaneous preterm birth. 62
31630580 2021
19
Combined therapy with vaginal progesterone, Arabin cervical pessary and cervical cerclage to prevent preterm delivery in high-risk women. 62
31438741 2021
20
Analysis of risk factors and predictors of pregnancy loss and strategies for the management of cervical insufficiency in pregnant women at a high risk of preterm birth. 62
31409178 2021
21
Successful outcome of giant chorioangioma. 62
34195146 2021
22
Chikungunya infection in pregnancy - reassuring maternal and perinatal outcomes: a retrospective observational study. 62
33040457 2021
23
A comparison of pregnancy outcome of emergency modified transvaginal cervicoisthmic cerclage performed in twin and singleton pregnancies. 62
33386955 2021
24
A ten year review of time interval between elective cervical cerclage removal at term and spontaneous onset of labour in Enugu, South-East Nigeria. 62
32500771 2021
25
Congenital Uterine Anomaly and Pelvic Organ Prolapse: A Rare Case of Pelvic Organ Prolapse in a Complete Bicornuate Uterus with Successful Pregnancy Outcomes Undiagnosed until the Time of Sacrocolpopexy. 62
33942587 2021
26
Fertility outcomes after preconceptional laparoscopic abdominal cerclage for second-trimester pregnancy losses. 62
33360240 2021
27
Minimally Invasive Laparoscopic Transabdominal Cerclage with a "Needle-Free" Technique: A Single-Center Experience. 62
33326965 2021
28
Evaluation of cervical length and optimal timing for pregnancy after cervical conization in patients with cervical intraepithelial neoplasia: A retrospective study. 62
33285731 2020
29
The temporal link between prenatal steroid therapy and labor. 62
33387425 2020
30
Removal of an Abdominal Cerclage by Colpotomy: A Novel and Minimally Invasive Technique. 62
32474172 2020
31
Pregnancy-preserving Laparoendoscopic Single-site Surgery for Gynecologic Disease: A Case Series. 62
32126300 2020
32
[Clinical efficacy of surgical opportunity of the modified transvaginal cervicoisthmic cerclage in treatment of the cervical incompetence]. 62
32993250 2020
33
[MAVRIC study: when abdominal cerclage is preferable to vaginal cerclage]. 62
33112514 2020
34
Arabin cervical pessary with vaginal progesterone versus vaginal progesterone for preventing preterm delivery. 62
30669913 2020
35
Anatomical and functional changes in arteries of uterine circulation after modified laparoscopic transabdominal cerclage in pregnancy: A case report and review of the literature. 62
32765735 2020
36
The Conundrum of Prematurity and Pregnancy Outcomes after Fertility Sparing Treatment Modalities for Early Stage Cervical Cancer:  A Systematic Review of the Literature. 62
33009739 2020
37
Management of pregnancy after fertility-sparing surgery for cervical cancer. 62
32416616 2020
38
Interval Laparoscopic Transabdominal Cervical Cerclage (ILTACC) Using Needleless Mersilene Tape for Cervical Incompetence. 62
33101915 2020
39
Laparoscopic Transabdominal Cerclage for Cervical Incompetence: A Feasible and Effective Treatment in 10 Steps. 62
31678560 2020
40
Fertility and Endocrine Preservation in the Management of Colorectal Cancer in Women. 62
32384402 2020
41
Transabdominal cerclage (TAC) as a new tool for the treatment of cervical incompetence (CI). 62
32566598 2020
42
Changes in the perinatal outcomes of twin pregnancies delivered at a tertiary referral center in Korea during a 24-year period from 1995 to 2018. 62
32489969 2020
43
Non-typeable Haemophilus influenzae-associated early pregnancy loss: an emerging neonatal and maternal pathogen. 62
31549360 2020
44
The impact of hymenectomy on future gynecological and obstetrical outcomes. 62
30173591 2020
45
An update on uterine cervix pathologies related to infertility. 62
32228872 2020
46
Successful heterotopic pregnancy with prior radical trachelectomy after transabdominal cervico isthimic cerclage with methotrexate treatment. 62
32028544 2020
47
McDonald versus modified Shirodkar rescue cerclage in women with prolapsed fetal membranes. 62
30122099 2020
48
Intrapartum cervical lacerations and their impact on future pregnancy outcome. 62
30189764 2020
49
Diagnosis and treatment of cervical incompetence combined with intrauterine adhesions. 62
32175348 2020
50
Are women with cervical incompetence at a higher risk of experiencing urinary and pelvic organ prolapse symptoms? 62
31123796 2020
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Variations for Cervical Incompetence

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Expression for Cervical Incompetence

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Search GEO for disease gene expression data for Cervical Incompetence.
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Pathways for Cervical Incompetence

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Pathways related to Cervical Incompetence according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Extracellular matrix organization 66
Show member pathways
 12.2 FN1 DCN CRTAP COL5A1
2
ECM proteoglycans 66
Show member pathways
 11.72 FN1 DCN COL5A1
3
Mesenchymal Stem Cells and Lineage-specific Markers 65
10.78 IL6 FN1 DCN
4
Overview of nanoparticle effects 74
10.43 IL6 FN1
5
miR-509-3p alteration of YAP1/ECM axis 74
10.19 FN1 COL5A1
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GO Terms for Cervical Incompetence

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Cellular components related to Cervical Incompetence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.32 IL6 IGFBP1 FN1 CRTAP COL5A1

Molecular functions related to Cervical Incompetence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteoglycan binding GO:0043394 9.26 FN1 COL5A1
2 collagen binding GO:0005518 9.1 FN1 DCN CRTAP
Sources

Sources for Cervical Incompetence

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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