MCID: CRV037
MIFTS: 33

Cervical Mucinous Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervical Mucinous Adenocarcinoma

MalaCards integrated aliases for Cervical Mucinous Adenocarcinoma:

Name: Cervical Mucinous Adenocarcinoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:3701
NCIt 49 C36095
UMLS 71 C1332919

Summaries for Cervical Mucinous Adenocarcinoma

Disease Ontology : 12 A cervical adenocarcinoma that derives from mucin producing epithelial cells.

MalaCards based summary : Cervical Mucinous Adenocarcinoma is related to cervical adenoma malignum and mucinous adenocarcinoma. An important gene associated with Cervical Mucinous Adenocarcinoma is RAB8A (RAB8A, Member RAS Oncogene Family), and among its related pathways/superpathways are Endometrial cancer and Development HGF signaling pathway. Affiliated tissues include breast, lung and skin, and related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Cervical Mucinous Adenocarcinoma

Diseases related to Cervical Mucinous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 401)
# Related Disease Score Top Affiliating Genes
1 cervical adenoma malignum 31.8 STK11 RAB8A MSH6 MSH2 MME KRT7
2 mucinous adenocarcinoma 29.3 TP53 PGR KRT7 ESR1 CDKN2A
3 cervical cancer 28.3 TP53 STK11 PTEN MAPK1 ESR1 CDKN2A
4 adenocarcinoma 27.8 TP53 STK11 PTEN MSH6 MSH2 KRT7
5 villoglandular variant cervical mucinous adenocarcinoma 12.7
6 signet ring cell variant cervical mucinous adenocarcinoma 12.7
7 intestinal variant cervical mucinous adenocarcinoma 12.7
8 endocervical type cervical mucinous adenocarcinoma 12.5
9 mixed endometrial stromal and smooth muscle tumor 10.6 MME CALD1
10 fallopian tube leiomyoma 10.6 MME CALD1
11 urethra leiomyoma 10.6 MME CALD1
12 fallopian tube benign neoplasm 10.6 MME CALD1
13 bartholin's duct cyst 10.6 HMGA2 CALD1
14 lung combined type small cell carcinoma 10.5 MME CALD1
15 bone leiomyosarcoma 10.5 KRT7 CALD1
16 nephrogenic adenofibroma 10.5 KRT7 CALD1
17 pulmonary vein leiomyosarcoma 10.5 PGR CALD1
18 cervical adenomyoma 10.5 PGR MME
19 nephrogenic adenoma of urinary bladder 10.5 MME KRT7
20 wolffian duct adenoma 10.5 MME KRT7
21 peritoneal benign neoplasm 10.5 PGR CALD1
22 mixed epithelial stromal tumour 10.5 MME KRT7
23 atypical polypoid adenomyoma 10.5 MME CALD1
24 female urethral cancer 10.5 MME KRT7
25 epididymal neoplasm 10.5 MME KRT7
26 clear cell papillary renal cell carcinoma 10.4 MME KRT7
27 chromophil adenoma of the kidney 10.4 MME KRT7
28 bartholin's gland disease 10.4 PGR KRT7
29 external ear carcinoma 10.4 PGR KRT7
30 cervical basaloid squamous cell carcinoma 10.4 KRT7 CDKN2A
31 heart leiomyosarcoma 10.4 CDKN2A CALD1
32 cellular leiomyoma 10.4 MME CALD1
33 benign metastasizing leiomyoma 10.4 PGR KRT7
34 endometrial transitional cell carcinoma 10.4 KRT7 CDKN2A
35 clear cell hidradenoma 10.4 MME KRT7
36 anus basaloid carcinoma 10.4 KRT7 CDKN2A
37 cervical adenoid cystic carcinoma 10.4 KRT7 CDKN2A
38 pleomorphic lipoma 10.4 PGR HMGA2
39 nephrogenic adenoma of the urethra 10.4 MME KRT7
40 endometrial squamous cell carcinoma 10.4 PGR CDKN2A
41 breast mucinous carcinoma 10.4 PGR KRT7
42 cystadenofibroma 10.4 MME KRT7
43 malignant spiradenoma 10.4 TP53 KRT7
44 subareolar duct papillomatosis 10.4 MME KRT7 CALD1
45 nipple neoplasm 10.4 MME KRT7 CALD1
46 pancreatic foamy gland adenocarcinoma 10.4 TP53 KRT7
47 inflammatory liposarcoma 10.4 MME CDKN2A
48 urethral benign neoplasm 10.4 MME KRT7 CALD1
49 benign mesenchymoma 10.4 KRT7 HMGA2
50 endometrial mucinous adenocarcinoma 10.4 PGR CDKN2A

Graphical network of the top 20 diseases related to Cervical Mucinous Adenocarcinoma:



Diseases related to Cervical Mucinous Adenocarcinoma

Symptoms & Phenotypes for Cervical Mucinous Adenocarcinoma

MGI Mouse Phenotypes related to Cervical Mucinous Adenocarcinoma:

45 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.43 CDKN2A ESR1 GATA3 KRT7 MAP2K7 MAPK1
2 homeostasis/metabolism MP:0005376 10.38 CDKN2A ESR1 GATA3 KRT7 MAP2K7 MAPK1
3 integument MP:0010771 10.32 CDKN2A ESR1 GATA3 MAP2K7 MAPK1 MLANA
4 endocrine/exocrine gland MP:0005379 10.26 CDKN2A ESR1 GATA3 MAP2K7 MAPK1 PGR
5 immune system MP:0005387 10.26 CDKN2A ESR1 GATA3 MAPK1 MME MSH2
6 mortality/aging MP:0010768 10.26 CDKN2A ESR1 GATA3 MAP2K7 MAPK1 MSH2
7 hematopoietic system MP:0005397 10.25 CDKN2A ESR1 GATA3 MAPK1 MSH2 MSH6
8 digestive/alimentary MP:0005381 10.23 CDKN2A ESR1 GATA3 MAPK1 MSH2 PTEN
9 embryo MP:0005380 10.17 CDKN2A ESR1 GATA3 MAPK1 PGR PTEN
10 neoplasm MP:0002006 10.13 CDKN2A ESR1 MAP2K7 MAPK1 MSH2 MSH6
11 nervous system MP:0003631 10.1 CDKN2A ESR1 GATA3 MAP2K7 MAPK1 MME
12 muscle MP:0005369 10.06 CDKN2A ESR1 GATA3 MAPK1 PGR PTEN
13 liver/biliary system MP:0005370 10.04 CDKN2A ESR1 MAPK1 MME PTEN STK11
14 no phenotypic analysis MP:0003012 9.91 CDKN2A ESR1 GATA3 MLANA PGR STK11
15 reproductive system MP:0005389 9.81 CDKN2A ESR1 GATA3 MAP2K7 MAPK1 PGR
16 renal/urinary system MP:0005367 9.8 ESR1 GATA3 KRT7 PTEN RAB8A STK11
17 pigmentation MP:0001186 9.72 CDKN2A GATA3 MLANA PTEN TP53
18 respiratory system MP:0005388 9.5 CDKN2A ESR1 MAPK1 PTEN RAB8A STK11
19 vision/eye MP:0005391 9.23 CDKN2A GATA3 MAP2K7 MAPK1 PTEN RAB8A

Drugs & Therapeutics for Cervical Mucinous Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Cervical Mucinous Adenocarcinoma

Genetic Tests for Cervical Mucinous Adenocarcinoma

Anatomical Context for Cervical Mucinous Adenocarcinoma

MalaCards organs/tissues related to Cervical Mucinous Adenocarcinoma:

40
Breast, Lung, Skin, Ovary, Kidney, Tongue, Thymus

Publications for Cervical Mucinous Adenocarcinoma

Articles related to Cervical Mucinous Adenocarcinoma:

# Title Authors PMID Year
1
Non-human Papillomavirus Cervical Mucinous Adenocarcinoma in a Phenotypic Male with Congenital Adrenal Hyperplasia. 61
30680268 2018
2
Mutational analysis of the RAS/RAF/MEK/ERK signaling pathway in 260 Han Chinese patients with cervical carcinoma. 61
28781678 2017

Variations for Cervical Mucinous Adenocarcinoma

Expression for Cervical Mucinous Adenocarcinoma

Search GEO for disease gene expression data for Cervical Mucinous Adenocarcinoma.

Pathways for Cervical Mucinous Adenocarcinoma

Pathways related to Cervical Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.72 TP53 PTEN MSH6 MSH2 MAPK1 CDKN2A
2
Show member pathways
12.63 TP53 PTEN MAPK1 MAP2K7 ESR1
3 12.59 TP53 PTEN MSH6 MSH2 MAPK1 ESR1
4
Show member pathways
12.51 TP53 PTEN PGR MAPK1 ESR1 CDKN2A
5 12.42 TP53 MSH6 MSH2 CDKN2A
6
Show member pathways
12.41 TP53 STK11 PTEN MAPK1
7 12.41 TP53 PTEN MAPK1 HMGA2 CDKN2A
8
Show member pathways
12.35 TP53 STK11 RAB8A MAPK1
9
Show member pathways
12.31 TP53 PTEN MAPK1 GATA3
10
Show member pathways
12.3 TP53 PTEN MSH6 MAPK1 MAP2K7 ESR1
11 12.25 TP53 PTEN MAPK1 CDKN2A
12
Show member pathways
12.13 PGR MAPK1 ESR1 CDKN2A
13 12.09 TP53 MSH6 MSH2 MAPK1
14 12.07 TP53 PTEN MAPK1 CDKN2A
15 11.97 STK11 RAB8A PTEN MAPK1
16 11.84 TP53 PTEN MAPK1 CDKN2A
17 11.8 TP53 PTEN MAPK1 CDKN2A
18 11.76 TP53 PTEN MAPK1 CDKN2A
19
Show member pathways
11.74 TP53 MSH6 MSH2
20 11.72 TP53 MAPK1 GATA3
21 11.66 TP53 MAPK1 CDKN2A
22 11.63 TP53 PTEN MAPK1
23 11.51 TP53 MAPK1 CDKN2A
24 11.48 TP53 MAP2K7 CDKN2A
25 11.36 TP53 STK11 ESR1
26 11.35 TP53 STK11 PTEN MSH6 MSH2 MAPK1
27 11.29 TP53 PTEN ESR1
28 11.22 TP53 PTEN MSH6 MSH2
29 11.22 TP53 MSH6 MSH2 MAPK1 CDKN2A
30 11.19 TP53 MAPK1 CDKN2A
31 10.92 PGR MAPK1 MAP2K7
32 10.8 MAPK1 MAP2K7

GO Terms for Cervical Mucinous Adenocarcinoma

Cellular components related to Cervical Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.13 TP53 STK11 PTEN PGR MSH6 MSH2
2 cytosol GO:0005829 10.03 TP53 STK11 RAB8A PTEN PGR MSH6
3 nucleoplasm GO:0005654 9.9 TP53 STK11 PTEN PGR MSH6 MSH2
4 mismatch repair complex GO:0032300 9.37 MSH6 MSH2
5 senescence-associated heterochromatin focus GO:0035985 8.96 HMGA2 CDKN2A
6 MutSalpha complex GO:0032301 8.62 MSH6 MSH2

Biological processes related to Cervical Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.96 TP53 STK11 MSH6 MSH2 MAPK1
2 negative regulation of gene expression GO:0010629 9.91 TP53 PGR GATA3 ESR1
3 negative regulation of cell proliferation GO:0008285 9.91 TP53 STK11 PTEN GATA3 CDKN2A
4 protein deubiquitination GO:0016579 9.9 TP53 PTEN GATA3 ESR1
5 apoptotic process GO:0006915 9.88 TP53 STK11 PTEN MAPK1 MAP2K7 CDKN2A
6 regulation of protein stability GO:0031647 9.75 PTEN MAPK1 CDKN2A
7 positive regulation of gene expression GO:0010628 9.73 TP53 PTEN MAPK1 HMGA2 GATA3 CDKN2A
8 response to estrogen GO:0043627 9.71 MAPK1 GATA3 ESR1
9 learning or memory GO:0007611 9.7 PTEN MME MAPK1
10 cell cycle arrest GO:0007050 9.62 TP53 STK11 MSH2 CDKN2A
11 protein localization to chromatin GO:0071168 9.61 MSH2 ESR1
12 response to UV GO:0009411 9.61 TP53 MSH6 MAP2K7
13 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.59 TP53 ESR1
14 response to UV-B GO:0010224 9.58 TP53 MSH2
15 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.57 TP53 ESR1
16 cellular response to UV-B GO:0071493 9.55 STK11 MME
17 positive regulation of transcription, DNA-templated GO:0045893 9.5 TP53 MAPK1 MAP2K7 HMGA2 GATA3 ESR1
18 positive regulation of helicase activity GO:0051096 9.49 MSH6 MSH2
19 maintenance of DNA repeat elements GO:0043570 9.48 MSH6 MSH2
20 somatic recombination of immunoglobulin gene segments GO:0016447 9.46 MSH6 MSH2
21 senescence-associated heterochromatin focus assembly GO:0035986 9.37 HMGA2 CDKN2A
22 determination of adult lifespan GO:0008340 9.33 TP53 MSH6 MSH2
23 replicative senescence GO:0090399 8.8 TP53 MME CDKN2A

Molecular functions related to Cervical Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.19 TP53 STK11 RAB8A PTEN PGR MSH6
2 DNA binding GO:0003677 10.09 TP53 PGR MSH6 MSH2 MAPK1 HMGA2
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.92 TP53 PGR HMGA2 GATA3 ESR1
4 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.85 TP53 PGR HMGA2 GATA3 ESR1
5 magnesium ion binding GO:0000287 9.81 STK11 MSH6 MSH2 MAP2K7
6 transcription factor binding GO:0008134 9.63 TP53 MAPK1 HMGA2 GATA3 ESR1 CDKN2A
7 mismatched DNA binding GO:0030983 9.54 MSH6 MSH2
8 enzyme binding GO:0019899 9.5 TP53 PTEN PGR MSH6 MSH2 MAP2K7
9 MutLalpha complex binding GO:0032405 9.49 MSH6 MSH2
10 oxidized purine DNA binding GO:0032357 9.48 MSH6 MSH2
11 guanine/thymine mispair binding GO:0032137 9.4 MSH6 MSH2
12 single guanine insertion binding GO:0032142 9.37 MSH6 MSH2
13 single thymine insertion binding GO:0032143 9.32 MSH6 MSH2
14 protein kinase binding GO:0019901 9.23 TP53 RAB8A PTEN MSH2 MAPK1 MAP2K7

Sources for Cervical Mucinous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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