Cervical Non-Keratinizing Squamous Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CRV020 MIFTS: 23	Cervical Non-Keratinizing Squamous Cell Carcinoma Categories: Cancer diseases, Reproductive diseases
Genes Related diseases Pathways Expand all tables

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Aliases & Classifications for Cervical Non-Keratinizing Squamous Cell Carcinoma

MalaCards integrated aliases for Cervical Non-Keratinizing Squamous Cell Carcinoma:

Name: Cervical Non-Keratinizing Squamous Cell Carcinoma ¹² ¹⁵ ⁷⁰

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7961

NCIt ⁵⁰ C40188

UMLS ⁷⁰ C1518366

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Summaries for Cervical Non-Keratinizing Squamous Cell Carcinoma

Disease Ontology : ¹² A cervial squamous cell carcinoma that is characterized by polygonal squamous cells growing in sheets or nests but keratin pearls are not present.

MalaCards based summary : Cervical Non-Keratinizing Squamous Cell Carcinoma is related to cervical keratinizing squamous cell carcinoma. An important gene associated with Cervical Non-Keratinizing Squamous Cell Carcinoma is ADAR (Adenosine Deaminase RNA Specific), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Related phenotypes are cardiovascular system and cellular

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Related Diseases for Cervical Non-Keratinizing Squamous Cell Carcinoma

Diseases related to Cervical Non-Keratinizing Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	cervical keratinizing squamous cell carcinoma	9.9	RAP1B PRKACB ADAR

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Symptoms & Phenotypes for Cervical Non-Keratinizing Squamous Cell Carcinoma

MGI Mouse Phenotypes related to Cervical Non-Keratinizing Squamous Cell Carcinoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.23	ADA ADAR AGO2 ELAVL1 FXR1 GSK3B
2	cellular	MP:0005384	10.21	ADA ADAR AGO2 DAB2 ELAVL1 GSK3B
3	growth/size/body region	MP:0005378	10.13	ADA ADAR AGO1 AGO2 DAB2 ELAVL1
4	embryo	MP:0005380	10.06	ADA ADAR AGO2 DAB2 ELAVL1 ITGB1
5	hematopoietic system	MP:0005397	10.03	ADA ADAR AGO2 ELAVL1 FXR1 ITGB1
6	endocrine/exocrine gland	MP:0005379	10.02	ADA AGO2 ELAVL1 FXR1 GSK3B ITGB1
7	immune system	MP:0005387	9.9	ADA ADAR AGO2 ELAVL1 FXR1 GSK3B
8	mortality/aging	MP:0010768	9.86	ADA ADAR AGO1 AGO2 DAB2 ELAVL1
9	muscle	MP:0005369	9.23	ADA ELAVL1 FXR1 GSK3B ITGB1 MAPK8

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Drugs & Therapeutics for Cervical Non-Keratinizing Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Cervical Non-Keratinizing Squamous Cell Carcinoma

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Genetic Tests for Cervical Non-Keratinizing Squamous Cell Carcinoma

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Anatomical Context for Cervical Non-Keratinizing Squamous Cell Carcinoma

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Publications for Cervical Non-Keratinizing Squamous Cell Carcinoma

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Genes for Cervical Non-Keratinizing Squamous Cell Carcinoma

Genes related to Cervical Non-Keratinizing Squamous Cell Carcinoma (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ADAR	Adenosine Deaminase RNA Specific	Protein Coding	5.78	DISEASES inferred ¹⁵
2	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	5	DISEASES inferred ¹⁵
3	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	4.93	DISEASES inferred ¹⁵
4	FXR1	FMR1 Autosomal Homolog 1	Protein Coding	4.9	DISEASES inferred ¹⁵
5	TNRC6A	Trinucleotide Repeat Containing Adaptor 6A	Protein Coding	4.89	DISEASES inferred ¹⁵
6	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	4.82	DISEASES inferred ¹⁵
7	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	4.76	DISEASES inferred ¹⁵
8	DAB2	DAB Adaptor Protein 2	Protein Coding	4.7	DISEASES inferred ¹⁵
9	ZFP36	ZFP36 Ring Finger Protein	Protein Coding	4.66	DISEASES inferred ¹⁵
10	AGO1	Argonaute RISC Component 1	Protein Coding	4.62	DISEASES inferred ¹⁵
11	MIR106B	MicroRNA 106b	RNA Gene	4.12	DISEASES inferred ¹⁵
12	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	4.08	DISEASES inferred ¹⁵
13	ADA	Adenosine Deaminase	Protein Coding	3.98	DISEASES inferred ¹⁵
14	MIR200B	MicroRNA 200b	RNA Gene	3.97	DISEASES inferred ¹⁵
15	ELAVL1	ELAV Like RNA Binding Protein 1	Protein Coding	3.95	DISEASES inferred ¹⁵
16	AGO2	Argonaute RISC Catalytic Component 2	Protein Coding	3.78	DISEASES inferred ¹⁵
17	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	3.74	DISEASES inferred ¹⁵
18	ITGB1	Integrin Subunit Beta 1	Protein Coding	3.68	DISEASES inferred ¹⁵
19	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	3.58	DISEASES inferred ¹⁵

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Variations for Cervical Non-Keratinizing Squamous Cell Carcinoma

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Expression for Cervical Non-Keratinizing Squamous Cell Carcinoma

Search GEO for disease gene expression data for Cervical Non-Keratinizing Squamous Cell Carcinoma.

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Pathways for Cervical Non-Keratinizing Squamous Cell Carcinoma

Pathways related to Cervical Non-Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 61)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	14	TNRC6A RAP1B RAP1A PRKACB PIK3R3 MAPK8
2	Class I MHC mediated antigen processing and presentation ⁶⁵ Show member pathways Adaptive Immune System ⁶⁵ Antigen processing- Ubiquitination and Proteasome degradation ⁶⁵	13.29	TNRC6A RAP1B RAP1A PRKACB PIK3R3 ITGB1
3	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Lipid and atherosclerosis ³⁶ Regulation of toll-like receptor signaling pathway ¹	13.18	RAP1B RAP1A PIK3R3 PIK3CG MAPK8 GSK3B
4	Sertoli-Sertoli Cell Junction Dynamics ⁶³ Show member pathways Epithelial Tight Junctions ⁶³ Germ Cell-Sertoli Cell Junction Dynamics ⁶³	12.91	PRKACB PIK3R3 MAPK8 ITGB1 GSK3B
5	Human cytomegalovirus infection ³⁶ Show member pathways Human immunodeficiency virus 1 infection ³⁶ Kaposi sarcoma-associated herpesvirus infection ³⁶	12.89	ZFP36 PRKACB PIK3R3 PIK3CG MAPK8 GSK3B
6	Regulation of lipid metabolism Insulin signaling-generic cascades ²³ Show member pathways acetyl-CoA biosynthesis from citrate ¹ Butyrate-induced histone acetylation ¹ Cell adhesion PLAU signaling ²³ Class IB PI3K non-lipid kinase events ¹ Development CNTF receptor signaling ²³ Development Growth hormone signaling via PI3K/AKT and MAPK cascades ²³ ErbB2/ErbB3 signaling events ¹ Glucose Homeostasis ¹ Insulin signaling pathway ³⁶ IRS activation ⁶⁵ Signal attenuation ⁶⁵ Transcription Receptor-mediated HIF regulation ²³ Translation Regulation of EIF2 activity ²³ Translation Regulation of EIF4F activity ²³ Translation Insulin regulation of translation ²³	12.88	PRKACB PIK3R3 MAPK8 ITGB1 GSK3B
7	Pathways in cancer ³⁶	12.82	PRKACB PIK3R3 MAPK8 ITGB1 GSK3B
8	NFAT and Cardiac Hypertrophy ⁶³ Show member pathways IGF1R Signaling ⁶³ Signaling Involved in Cardiac Hypertrophy ⁶³	12.81	RAP1A PRKACB PIK3R3 MAPK8 ITGB1 GSK3B
9	Development Angiotensin activation of ERK ²³ Show member pathways Cell adhesion Integrin inside-out signaling ²³ Development ACM2 and ACM4 activation of ERK ²³ Development Angiotensin signaling via PYK2 ²³ Development EDNRB signaling ²³ Development EPO-induced MAPK pathway ²³ Development G-Proteins mediated regulation MARK-ERK signaling ²³ Signal transduction IP3 signaling ²³	12.79	RAP1A PIK3R3 PIK3CG MAPK8 ITGB1
10	Beta-Adrenergic Signaling ⁶³ Show member pathways CDK5 Pathway ⁶³ Erythropoietin Pathway ⁶³ Insulin Receptor Pathway ⁶³	12.77	PRKACB PIK3R3 MAPK8 ITGB1 GSK3B
11	Circadian entrainment ³⁶ Show member pathways Cholinergic synapse ³⁶ Dopaminergic synapse ³⁶ Glutamatergic synapse ³⁶ Synaptic Neurotransmission Pathways: Glutamatergic Excitation ⁶⁴	12.73	PRKACB PIK3R3 PIK3CG MAPK8 GSK3B
12	Downstream signaling events of B Cell Receptor (BCR) ⁶⁵ Show member pathways Activation of RAS in B cells ⁶⁵ Signaling by the B Cell Receptor (BCR) ⁶⁵	12.69	TNRC6A PIK3R3 GSK3B AGO2 AGO1
13	Focal Adhesion ³⁶ ¹ Show member pathways HGF Pathway ⁶³ Integrin-mediated Cell Adhesion ¹	12.68	RAP1B RAP1A PIK3R3 PIK3CG MAPK8 ITGB1
14	Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways ⁶⁴ Show member pathways Blood-Brain Barrier and Immune Cell Transmigration: CCL2/MCP-1 Signaling Pathways ⁶⁴ Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling Pathways ⁶⁴ Blood-Brain Barrier and Immune Cell Transmigration: VEGF Signaling Pathways ⁶⁴ Leukocyte transendothelial migration ³⁶	12.63	RAP1B RAP1A PIK3R3 PIK3CG ITGB1
15	Ras signaling pathway ³⁶ Show member pathways Rap1 signaling pathway ³⁶	12.63	RAP1B RAP1A PRKACB PIK3R3 MAPK8 ITGB1
16	CCR5 Pathway in Macrophages ⁶³ Show member pathways Androgen Signaling ⁶³ Chemokine Signaling ⁶³ Chemokine signaling pathway ³⁶	12.62	RAP1B RAP1A PRKACB PIK3R3 PIK3CG MAPK8
17	Development Endothelin-1/EDNRA signaling ²³ Show member pathways Cytoskeleton remodeling FAK signaling ²³ Development Endothelin-1/EDNRA transactivation of EGFR ²³ GnRH signaling pathway ³⁶ Inflammatory mediator regulation of TRP channels ³⁶	12.61	PRKACB PIK3R3 MAPK8 GSK3B
18	Development HGF signaling pathway ²³ Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²³ Apoptosis and survival NGF signaling pathway ²³ Apoptosis and survival Role of CDK5 in neuronal death and survival ²³ Development Neurotrophin family signaling ²³ MET activates PTPN11 ⁶⁵ MET activates STAT3 ⁶⁵ Neurotrophin signaling pathway ³⁶ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.6	RAP1B RAP1A PIK3R3 MAPK8 ITGB1 GSK3B
19	Cytoskeletal Signaling ⁴	12.51	RAP1B RAP1A ITGB1 DAB2
20	Angiopoietin Like Protein 8 Regulatory Pathway ¹ Show member pathways Insulin Signaling ¹ Liver X Receptor Pathway ¹	12.5	PIK3R3 PIK3CG MAPK8 GSK3B
21	ErbB signaling pathway ³⁶ ¹ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ³⁶ Renal cell carcinoma ³⁶ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.44	RAP1B RAP1A PIK3R3 PIK3CG MAPK8 GSK3B
22	AMP-activated Protein Kinase (AMPK) Signaling ¹ Show member pathways AMPK signaling pathway ³⁶ AMPK Signaling Pathway ⁶⁶	12.43	PRKACB PIK3R3 PIK3CG GSK3B ELAVL1
23	Prolactin Signaling Pathway ¹ ³⁶ Show member pathways Development Prolactin receptor signaling ²³ Leptin signaling pathway ¹	12.42	PIK3R3 PIK3CG MAPK8 ITGB1 GSK3B
24	B cell receptor signaling pathway (KEGG) ³⁶ Show member pathways B Cell Receptor Signaling Pathway ¹ BCR signaling pathway ¹	12.38	PIK3R3 PIK3CG MAPK8 GSK3B
25	Shigellosis ³⁶	12.37	PIK3R3 MAPK8 ITGB1 GSK3B
26	EphB-EphrinB Signaling ⁶³ Show member pathways Cytoskeleton remodeling Reverse signaling by ephrin B ²³ Ephrin-Eph Signaling ⁶³	12.36	PIK3CG MAPK8 ITGB1 GSK3B
27	G-protein signaling RAC1 in cellular process ²³ Show member pathways CDC42 signaling events ¹ Cytoskeleton remodeling CDC42 in cellular processes ²³ RAC1 signaling pathway ¹	12.36	RAP1A PIK3R3 MAPK8 ITGB1 GSK3B
28	B Cell Receptor Signaling Pathway (sino) ⁶⁶ Show member pathways B Cell Receptor Signaling Pathway ⁶⁶	12.36	RAP1B RAP1A PIK3CG MAPK8 GSK3B
29	G-protein signaling G-Protein alpha-i signaling cascades ²³ Show member pathways Development Beta-adrenergic receptors regulation of ERK ²³ G-protein signaling G-Protein alpha-s signaling cascades ²³ G-protein signaling G-Protein beta/gamma signaling cascades ²³	12.34	RAP1A PRKACB PIK3CG GSK3B
30	Apoptosis Pathway ⁶⁹ Show member pathways Akt Pathway ⁶⁹ NF-kappaB Pathway ⁶⁹	12.34	PIK3R3 PIK3CG MAPK8 ITGB1 GSK3B
31	Human T-cell leukemia virus 1 infection ³⁶	12.3	ZFP36 PRKACB PIK3R3 MAPK8
32	cAMP signaling pathway ³⁶	12.21	RAP1B RAP1A PRKACB PIK3R3 MAPK8
33	Tight junction ³⁶	12.17	RAP1A PRKACB MAPK8 ITGB1
34	mTOR Pathway ⁶⁹ Show member pathways Insulin Pathway ⁶⁹ TGF-beta Pathway ⁶⁹	12.14	PIK3R3 PIK3CG MAPK8 GSK3B
35	MicroRNAs in cardiomyocyte hypertrophy ¹ Show member pathways Cardiac Hypertrophic Response ¹	12.13	PIK3R3 PIK3CG MAPK8 GSK3B
36	NGF Pathway ⁶³ Show member pathways TRKA Signaling ⁶³	12.1	RAP1B RAP1A PIK3R3 MAPK8
37	Yersinia infection ³⁶	12.04	PIK3R3 MAPK8 ITGB1 GSK3B
38	Thyroid hormone signaling pathway ³⁶	11.99	PRKACB PIK3R3 GSK3B
39	Development A2A receptor signaling ²³ Show member pathways Development A2B receptor- action via G-protein alpha s ²³	11.99	RAP1A PRKACB MAPK8 GSK3B
40	Insulin resistance ³⁶ Show member pathways protein O-[N-acetyl]-glucosylation ¹	11.94	PIK3R3 MAPK8 GSK3B
41	Long-term potentiation ³⁶ Show member pathways Common Pathways Underlying Drug Addiction ¹	11.94	RAP1B RAP1A PRKACB
42	DNA Damage Response (only ATM dependent) ¹	11.91	PIK3R3 PIK3CG MAPK8 GSK3B
43	Development EPO-induced Jak-STAT pathway ²³ Show member pathways EPO Receptor Signaling ¹ EPO signaling pathway ¹	11.87	RAP1A PIK3CG MAPK8
44	Type II diabetes mellitus ¹ ³⁶ Show member pathways Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics ⁶⁰	11.86	PIK3R3 PIK3CG MAPK8
45	TGF-beta Signaling Pathways ⁶⁴	11.86	PIK3R3 PIK3CG MAPK8
46	Corticotropin-releasing hormone signaling pathway ¹	11.84	RAP1B MAPK8 GSK3B
47	PI3K / Akt Signaling ⁴	11.84	PIK3R3 PIK3CG GSK3B
48	TP53 Regulates Metabolic Genes ⁶⁵	11.8	TNRC6A AGO2 AGO1
49	VEGF Pathway (Tocris) ⁶⁹ Show member pathways Sorafenib Pharmacodynamics ⁶⁰	11.79	PIK3R3 PIK3CG MAPK8
50	Glucocorticoid receptor regulatory network ¹	11.78	PRKACB MAPK8 GSK3B

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GO Terms for Cervical Non-Keratinizing Squamous Cell Carcinoma

Cellular components related to Cervical Non-Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:0005737	10.16	ZFP36 TNRC6A RAP1B RAP1A PRKACB PIK3CG
2	cytosol	GO:0005829	9.83	ZFP36 TNRC6A RAP1B RAP1A PRKACB PIK3R3
3	ribonucleoprotein complex	GO:1990904	9.71	ZFP36 ELAVL1 AGO2 AGO1
4	P-body	GO:0000932	9.62	ZFP36 TNRC6A AGO2 AGO1
5	cytoplasmic ribonucleoprotein granule	GO:0036464	9.61	FXR1 AGO2 AGO1
6	polysome	GO:0005844	9.54	FXR1 AGO2 AGO1
7	RISC complex	GO:0016442	9.33	TNRC6A AGO2 AGO1
8	RISC-loading complex	GO:0070578	8.8	ZFP36 AGO2 AGO1

Biological processes related to Cervical Non-Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 28)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of apoptotic process	GO:0043066	9.93	MIR200B MAPK8 GSK3B DAB2 ADAR ADA
2	positive regulation of gene expression	GO:0010628	9.91	TNRC6A PIK3R3 MAPK8 GSK3B AGO2 AGO1
3	negative regulation of gene expression	GO:0010629	9.88	TNRC6A MIR200B MIR106B AGO2 AGO1
4	regulation of translation	GO:0006417	9.83	TNRC6A FXR1 AGO2 AGO1
5	regulation of mRNA stability	GO:0043488	9.81	ZFP36 FXR1 ELAVL1
6	regulation of gene silencing by miRNA	GO:0060964	9.77	TNRC6A AGO2 AGO1
7	negative regulation of protein binding	GO:0032091	9.76	MAPK8 GSK3B DAB2
8	cellular response to cAMP	GO:0071320	9.73	RAP1B RAP1A PIK3CG
9	Wnt signaling pathway, calcium modulating pathway	GO:0007223	9.67	TNRC6A AGO2 AGO1
10	establishment of endothelial barrier	GO:0061028	9.64	RAP1B RAP1A
11	microvillus assembly	GO:0030033	9.63	RAP1B RAP1A
12	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	GO:1900153	9.62	ZFP36 AGO2
13	phosphatidylinositol-3-phosphate biosynthetic process	GO:0036092	9.62	PIK3R3 PIK3CG
14	response to carbohydrate	GO:0009743	9.61	RAP1B RAP1A
15	positive regulation of gene silencing by miRNA	GO:2000637	9.61	ZFP36 FXR1
16	Rap protein signal transduction	GO:0032486	9.6	RAP1B RAP1A
17	regulation of cell junction assembly	GO:1901888	9.58	RAP1B RAP1A
18	production of miRNAs involved in gene silencing by miRNA	GO:0035196	9.58	AGO2 AGO1 ADAR
19	RNA secondary structure unwinding	GO:0010501	9.57	AGO2 AGO1
20	negative regulation of synaptic vesicle exocytosis	GO:2000301	9.55	RAP1B RAP1A
21	mRNA cleavage involved in gene silencing by miRNA	GO:0035279	9.54	AGO2 AGO1
22	pre-miRNA processing	GO:0031054	9.54	AGO2 AGO1 ADAR
23	mRNA cleavage involved in gene silencing by siRNA	GO:0090625	9.51	AGO2 AGO1
24	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	GO:0060213	9.5	ZFP36 TNRC6A AGO2
25	posttranscriptional gene silencing by RNA	GO:0035194	9.43	TNRC6A AGO2 AGO1
26	gene silencing by RNA	GO:0031047	9.35	ZFP36 TNRC6A AGO2 AGO1 ADAR
27	miRNA loading onto RISC involved in gene silencing by miRNA	GO:0035280	9.33	AGO2 AGO1 ADAR
28	miRNA mediated inhibition of translation	GO:0035278	9.1	ZFP36 TNRC6A MIR200B MIR106B AGO2 AGO1

Molecular functions related to Cervical Non-Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	RNA binding	GO:0003723	9.95	ZFP36 TNRC6A FXR1 ELAVL1 AGO2 AGO1
2	mRNA binding	GO:0003729	9.56	ZFP36 FXR1 ELAVL1 AGO2
3	mRNA 3'-UTR binding	GO:0003730	9.46	MIR200B MIR106B FXR1 ELAVL1
4	core promoter sequence-specific DNA binding	GO:0001046	9.43	AGO2 AGO1
5	adenosine deaminase activity	GO:0004000	9.37	ADAR ADA
6	1-phosphatidylinositol-3-kinase activity	GO:0016303	9.32	PIK3R3 PIK3CG
7	miRNA binding	GO:0035198	9.13	ELAVL1 AGO2 AGO1
8	double-stranded RNA binding	GO:0003725	8.92	ELAVL1 AGO2 AGO1 ADAR

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Sources for Cervical Non-Keratinizing Squamous Cell Carcinoma

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