MCID: CRV020
MIFTS: 22

Cervical Non-Keratinizing Squamous Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervical Non-Keratinizing Squamous Cell Carcinoma

MalaCards integrated aliases for Cervical Non-Keratinizing Squamous Cell Carcinoma:

Name: Cervical Non-Keratinizing Squamous Cell Carcinoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:7961
NCIt 49 C40188
UMLS 71 C1518366

Summaries for Cervical Non-Keratinizing Squamous Cell Carcinoma

Disease Ontology : 12 A cervial squamous cell carcinoma that is characterized by polygonal squamous cells growing in sheets or nests but keratin pearls are not present.

MalaCards based summary : Cervical Non-Keratinizing Squamous Cell Carcinoma is related to cervical keratinizing squamous cell carcinoma. An important gene associated with Cervical Non-Keratinizing Squamous Cell Carcinoma is ADAR (Adenosine Deaminase RNA Specific), and among its related pathways/superpathways are Innate Immune System and Response to elevated platelet cytosolic Ca2+. Related phenotypes are cardiovascular system and cellular

Related Diseases for Cervical Non-Keratinizing Squamous Cell Carcinoma

Diseases related to Cervical Non-Keratinizing Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 cervical keratinizing squamous cell carcinoma 5.3 ZFP36 TNRC6A RAP1B RAP1A PRKACB PIK3R3

Symptoms & Phenotypes for Cervical Non-Keratinizing Squamous Cell Carcinoma

MGI Mouse Phenotypes related to Cervical Non-Keratinizing Squamous Cell Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.14 ADA ADAR AGO2 ELAVL1 FXR1 GSK3B
2 cellular MP:0005384 10.11 ADA ADAR AGO2 DAB2 ELAVL1 GSK3B
3 growth/size/body region MP:0005378 10.03 ADA ADAR AGO1 AGO2 DAB2 ELAVL1
4 embryo MP:0005380 9.92 ADA ADAR AGO2 DAB2 ELAVL1 ITGB1
5 hematopoietic system MP:0005397 9.9 ADA ADAR AGO2 ELAVL1 FXR1 ITGB1
6 immune system MP:0005387 9.65 ADA ADAR AGO2 ELAVL1 FXR1 GSK3B
7 mortality/aging MP:0010768 9.5 ADA ADAR AGO1 AGO2 DAB2 ELAVL1

Drugs & Therapeutics for Cervical Non-Keratinizing Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Cervical Non-Keratinizing Squamous Cell Carcinoma

Genetic Tests for Cervical Non-Keratinizing Squamous Cell Carcinoma

Anatomical Context for Cervical Non-Keratinizing Squamous Cell Carcinoma

Publications for Cervical Non-Keratinizing Squamous Cell Carcinoma

Variations for Cervical Non-Keratinizing Squamous Cell Carcinoma

Expression for Cervical Non-Keratinizing Squamous Cell Carcinoma

Search GEO for disease gene expression data for Cervical Non-Keratinizing Squamous Cell Carcinoma.

Pathways for Cervical Non-Keratinizing Squamous Cell Carcinoma

Pathways related to Cervical Non-Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 TNRC6A RAP1B RAP1A PRKACB PIK3R3 ITGB1
2
Show member pathways
13.24 RAP1B RAP1A PRKACB PIK3R3 PIK3CG ITGB1
3
Show member pathways
13.09 TNRC6A RAP1B RAP1A PRKACB PIK3R3 ITGB1
4
Show member pathways
12.9 PRKACB PIK3R3 PIK3CG ITGB1 GSK3B
5
Show member pathways
12.83 ZFP36 PRKACB PIK3R3 PIK3CG GSK3B
6
Show member pathways
12.76 RAP1B RAP1A PIK3R3 PIK3CG ITGB1 GSK3B
7
Show member pathways
12.75 RAP1A PRKACB PIK3R3 ITGB1 GSK3B
8
Show member pathways
12.73 RAP1B RAP1A PRKACB PIK3CG ITGB1 GSK3B
9
Show member pathways
12.71 RAP1B RAP1A PRKACB PIK3R3 PIK3CG GSK3B
10
Show member pathways
12.62 RAP1B RAP1A PRKACB PIK3R3 ITGB1
11
Show member pathways
12.6 TNRC6A PIK3R3 GSK3B AGO2 AGO1
12
Show member pathways
12.59 RAP1B RAP1A PIK3R3 ITGB1 GSK3B
13
Show member pathways
12.52 RAP1B RAP1A PIK3R3 PIK3CG ITGB1
14
Show member pathways
12.48 RAP1B RAP1A PIK3R3 PIK3CG GSK3B
15 12.43 RAP1B RAP1A ITGB1 DAB2
16
Show member pathways
12.38 PIK3R3 PIK3CG ITGB1 GSK3B
17
Show member pathways
12.34 RAP1B RAP1A PIK3CG GSK3B
18
Show member pathways
12.33 PIK3R3 PIK3CG ITGB1 GSK3B
19
Show member pathways
12.26 RAP1A PRKACB PIK3CG GSK3B
20 12.22 RAP1B RAP1A PRKACB PIK3R3
21
Show member pathways
12.22 PRKACB PIK3R3 PIK3CG GSK3B ELAVL1
22
Show member pathways
11.96 TNRC6A AGO2 AGO1
23
Show member pathways
11.95 RAP1A PRKACB GSK3B
24 11.94 RAP1B RAP1A ITGB1
25 11.92 PRKACB PIK3R3 GSK3B
26 11.92 PIK3R3 ITGB1 GSK3B
27 11.89 PIK3R3 PIK3CG GSK3B
28
Show member pathways
11.86 RAP1B RAP1A PRKACB
29
Show member pathways
11.85 PIK3R3 PIK3CG ITGB1 GSK3B
30 11.76 PIK3R3 PIK3CG GSK3B
31 11.72 ZFP36 FXR1 ELAVL1 AGO2 AGO1 ADAR
32 11.7 TNRC6A AGO2 AGO1
33 11.64 RAP1B RAP1A PRKACB ITGB1
34 11.44 PRKACB PIK3R3 GSK3B
35 11.19 RAP1B RAP1A PRKACB PIK3R3 PIK3CG ITGB1
36 11.1 PIK3CG ITGB1 GSK3B
37 11.06 PIK3R3 PIK3CG GSK3B
38 10.96 RAP1A ITGB1 GSK3B
39 10.78 RAP1B PRKACB
40 10.54 RAP1B RAP1A PRKACB

GO Terms for Cervical Non-Keratinizing Squamous Cell Carcinoma

Cellular components related to Cervical Non-Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.2 ZFP36 TNRC6A RAP1B RAP1A PRKACB PIK3CG
2 cytosol GO:0005829 10 ZFP36 TNRC6A RAP1B RAP1A PRKACB PIK3R3
3 glutamatergic synapse GO:0098978 9.77 RAP1A ITGB1 GSK3B FXR1 ELAVL1
4 ribonucleoprotein complex GO:1990904 9.73 ZFP36 ELAVL1 AGO2 AGO1
5 postsynapse GO:0098794 9.63 GSK3B FXR1 ELAVL1
6 polysome GO:0005844 9.58 FXR1 AGO2 AGO1
7 P-body GO:0000932 9.56 ZFP36 TNRC6A AGO2 AGO1
8 RISC complex GO:0016442 9.13 TNRC6A AGO2 AGO1
9 RISC-loading complex GO:0070578 8.8 ZFP36 AGO2 AGO1

Biological processes related to Cervical Non-Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 10 MIR200B GSK3B DAB2 ADAR ADA
2 positive regulation of gene expression GO:0010628 9.97 TNRC6A PIK3R3 GSK3B AGO2 AGO1
3 negative regulation of gene expression GO:0010629 9.83 TNRC6A MIR200B MIR106B AGO2 AGO1
4 negative regulation of angiogenesis GO:0016525 9.82 MIR200B MIR106B AGO1
5 regulation of mRNA stability GO:0043488 9.81 ZFP36 FXR1 ELAVL1
6 regulation of translation GO:0006417 9.78 TNRC6A FXR1 AGO2 AGO1
7 regulation of gene silencing by miRNA GO:0060964 9.75 TNRC6A AGO2 AGO1
8 cellular response to cAMP GO:0071320 9.7 RAP1B RAP1A PIK3CG
9 cell migration involved in sprouting angiogenesis GO:0002042 9.65 PIK3R3 ITGB1
10 3'-UTR-mediated mRNA stabilization GO:0070935 9.64 ZFP36 ELAVL1
11 establishment of endothelial barrier GO:0061028 9.64 RAP1B RAP1A
12 microvillus assembly GO:0030033 9.63 RAP1B RAP1A
13 Wnt signaling pathway, calcium modulating pathway GO:0007223 9.63 TNRC6A AGO2 AGO1
14 miRNA metabolic process GO:0010586 9.62 AGO2 AGO1
15 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900153 9.62 ZFP36 AGO2
16 response to carbohydrate GO:0009743 9.61 RAP1B RAP1A
17 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.61 PIK3R3 PIK3CG
18 positive regulation of gene silencing by miRNA GO:2000637 9.59 ZFP36 FXR1
19 Rap protein signal transduction GO:0032486 9.58 RAP1B RAP1A
20 production of miRNAs involved in gene silencing by miRNA GO:0035196 9.58 AGO2 AGO1 ADAR
21 RNA secondary structure unwinding GO:0010501 9.56 AGO2 AGO1
22 regulation of cell junction assembly GO:1901888 9.55 RAP1B RAP1A
23 negative regulation of synaptic vesicle exocytosis GO:2000301 9.54 RAP1B RAP1A
24 pre-miRNA processing GO:0031054 9.54 AGO2 AGO1 ADAR
25 mRNA cleavage involved in gene silencing by miRNA GO:0035279 9.51 AGO2 AGO1
26 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060213 9.5 ZFP36 TNRC6A AGO2
27 mRNA cleavage involved in gene silencing by siRNA GO:0090625 9.49 AGO2 AGO1
28 posttranscriptional gene silencing by RNA GO:0035194 9.43 TNRC6A AGO2 AGO1
29 gene silencing by RNA GO:0031047 9.35 ZFP36 TNRC6A AGO2 AGO1 ADAR
30 miRNA loading onto RISC involved in gene silencing by miRNA GO:0035280 9.33 AGO2 AGO1 ADAR
31 miRNA mediated inhibition of translation GO:0035278 9.1 ZFP36 TNRC6A MIR200B MIR106B AGO2 AGO1

Molecular functions related to Cervical Non-Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.36 ZFP36 TNRC6A RAP1B RAP1A PRKACB PIK3R3
2 RNA binding GO:0003723 9.98 ZFP36 TNRC6A FXR1 ELAVL1 AGO2 AGO1
3 mRNA binding GO:0003729 9.56 ZFP36 FXR1 ELAVL1 AGO2
4 core promoter sequence-specific DNA binding GO:0001046 9.48 AGO2 AGO1
5 core promoter binding GO:0001047 9.4 AGO2 AGO1
6 1-phosphatidylinositol-3-kinase activity GO:0016303 9.37 PIK3R3 PIK3CG
7 miRNA binding GO:0035198 9.33 ELAVL1 AGO2 AGO1
8 adenosine deaminase activity GO:0004000 9.32 ADAR ADA
9 mRNA 3'-UTR binding GO:0003730 9.26 MIR200B MIR106B FXR1 ELAVL1
10 double-stranded RNA binding GO:0003725 8.92 ELAVL1 AGO2 AGO1 ADAR

Sources for Cervical Non-Keratinizing Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....