Cervical Non-Keratinizing Squamous Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CRV020 MIFTS: 22	Cervical Non-Keratinizing Squamous Cell Carcinoma Categories: Cancer diseases, Reproductive diseases
Genes Related diseases Pathways Expand all tables

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Aliases & Classifications for Cervical Non-Keratinizing Squamous Cell Carcinoma

MalaCards integrated aliases for Cervical Non-Keratinizing Squamous Cell Carcinoma:

Name: Cervical Non-Keratinizing Squamous Cell Carcinoma ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7961

NCIt ⁴⁹ C40188

UMLS ⁷¹ C1518366

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Summaries for Cervical Non-Keratinizing Squamous Cell Carcinoma

Disease Ontology : ¹² A cervial squamous cell carcinoma that is characterized by polygonal squamous cells growing in sheets or nests but keratin pearls are not present.

MalaCards based summary : Cervical Non-Keratinizing Squamous Cell Carcinoma is related to cervical keratinizing squamous cell carcinoma. An important gene associated with Cervical Non-Keratinizing Squamous Cell Carcinoma is ADAR (Adenosine Deaminase RNA Specific), and among its related pathways/superpathways are Innate Immune System and Response to elevated platelet cytosolic Ca2+. Related phenotypes are cardiovascular system and cellular

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Related Diseases for Cervical Non-Keratinizing Squamous Cell Carcinoma

Diseases related to Cervical Non-Keratinizing Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	cervical keratinizing squamous cell carcinoma	5.3	ZFP36 TNRC6A RAP1B RAP1A PRKACB PIK3R3

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Symptoms & Phenotypes for Cervical Non-Keratinizing Squamous Cell Carcinoma

MGI Mouse Phenotypes related to Cervical Non-Keratinizing Squamous Cell Carcinoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.14	ADA ADAR AGO2 ELAVL1 FXR1 GSK3B
2	cellular	MP:0005384	10.11	ADA ADAR AGO2 DAB2 ELAVL1 GSK3B
3	growth/size/body region	MP:0005378	10.03	ADA ADAR AGO1 AGO2 DAB2 ELAVL1
4	embryo	MP:0005380	9.92	ADA ADAR AGO2 DAB2 ELAVL1 ITGB1
5	hematopoietic system	MP:0005397	9.9	ADA ADAR AGO2 ELAVL1 FXR1 ITGB1
6	immune system	MP:0005387	9.65	ADA ADAR AGO2 ELAVL1 FXR1 GSK3B
7	mortality/aging	MP:0010768	9.5	ADA ADAR AGO1 AGO2 DAB2 ELAVL1

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Drugs & Therapeutics for Cervical Non-Keratinizing Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Cervical Non-Keratinizing Squamous Cell Carcinoma

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Genetic Tests for Cervical Non-Keratinizing Squamous Cell Carcinoma

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Anatomical Context for Cervical Non-Keratinizing Squamous Cell Carcinoma

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Publications for Cervical Non-Keratinizing Squamous Cell Carcinoma

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Genes for Cervical Non-Keratinizing Squamous Cell Carcinoma

Genes related to Cervical Non-Keratinizing Squamous Cell Carcinoma (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ADAR	Adenosine Deaminase RNA Specific	Protein Coding	5.74	DISEASES inferred ¹⁵
2	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	5.11	DISEASES inferred ¹⁵
3	FXR1	FMR1 Autosomal Homolog 1	Protein Coding	5	DISEASES inferred ¹⁵
4	TNRC6A	Trinucleotide Repeat Containing Adaptor 6A	Protein Coding	4.98	DISEASES inferred ¹⁵
5	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	4.92	DISEASES inferred ¹⁵
6	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	4.87	DISEASES inferred ¹⁵
7	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	4.8	DISEASES inferred ¹⁵
8	DAB2	DAB Adaptor Protein 2	Protein Coding	4.79	DISEASES inferred ¹⁵
9	ZFP36	ZFP36 Ring Finger Protein	Protein Coding	4.76	DISEASES inferred ¹⁵
10	AGO1	Argonaute RISC Component 1	Protein Coding	4.7	DISEASES inferred ¹⁵
11	MIR106B	MicroRNA 106b	RNA Gene	4.22	DISEASES inferred ¹⁵
12	MIR200B	MicroRNA 200b	RNA Gene	4.08	DISEASES inferred ¹⁵
13	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	4.07	DISEASES inferred ¹⁵
14	ELAVL1	ELAV Like RNA Binding Protein 1	Protein Coding	4.05	DISEASES inferred ¹⁵
15	ADA	Adenosine Deaminase	Protein Coding	4.03	DISEASES inferred ¹⁵
16	AGO2	Argonaute RISC Catalytic Component 2	Protein Coding	3.88	DISEASES inferred ¹⁵
17	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	3.79	DISEASES inferred ¹⁵
18	ITGB1	Integrin Subunit Beta 1	Protein Coding	3.78	DISEASES inferred ¹⁵

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Variations for Cervical Non-Keratinizing Squamous Cell Carcinoma

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Expression for Cervical Non-Keratinizing Squamous Cell Carcinoma

Search GEO for disease gene expression data for Cervical Non-Keratinizing Squamous Cell Carcinoma.

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Pathways for Cervical Non-Keratinizing Squamous Cell Carcinoma

Pathways related to Cervical Non-Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 40)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.95	TNRC6A RAP1B RAP1A PRKACB PIK3R3 ITGB1
2	Response to elevated platelet cytosolic Ca2+ ⁶⁵ Show member pathways Disinhibition of SNARE formation ⁶⁵ Hemostasis ⁶⁵ Platelet activation, signaling and aggregation ⁶⁵ Platelet degranulation ⁶⁵	13.24	RAP1B RAP1A PRKACB PIK3R3 PIK3CG ITGB1
3	Class I MHC mediated antigen processing and presentation ⁶⁵ Show member pathways Adaptive Immune System ⁶⁵ Antigen processing- Ubiquitination and Proteasome degradation ⁶⁵	13.09	TNRC6A RAP1B RAP1A PRKACB PIK3R3 ITGB1
4	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	12.9	PRKACB PIK3R3 PIK3CG ITGB1 GSK3B
5	Human cytomegalovirus infection ³⁶ Show member pathways Human immunodeficiency virus 1 infection ³⁶ Kaposi sarcoma-associated herpesvirus infection ³⁶	12.83	ZFP36 PRKACB PIK3R3 PIK3CG GSK3B
6	Focal Adhesion ³⁶ ¹ Show member pathways HGF Pathway ⁶³ Integrin-mediated Cell Adhesion ¹	12.76	RAP1B RAP1A PIK3R3 PIK3CG ITGB1 GSK3B
7	NFAT and Cardiac Hypertrophy ⁶³ Show member pathways IGF1R Signaling ⁶³ Signaling Involved in Cardiac Hypertrophy ⁶³	12.75	RAP1A PRKACB PIK3R3 ITGB1 GSK3B
8	MAPK Erk Pathway ⁶⁶ Show member pathways Actin Dynamics Signaling Pathway ⁶⁶ G Protein coupled Receptors Signaling ⁶⁶	12.73	RAP1B RAP1A PRKACB PIK3CG ITGB1 GSK3B
9	CCR5 Pathway in Macrophages ⁶³ Show member pathways Androgen Signaling ⁶³ Chemokine Signaling ⁶³ Chemokine signaling pathway ³⁶	12.71	RAP1B RAP1A PRKACB PIK3R3 PIK3CG GSK3B
10	Ras signaling pathway ³⁶ Show member pathways Rap1 signaling pathway ³⁶	12.62	RAP1B RAP1A PRKACB PIK3R3 ITGB1
11	Downstream signaling events of B Cell Receptor (BCR) ⁶⁵ Show member pathways Activation of RAS in B cells ⁶⁵ Signaling by the B Cell Receptor (BCR) ⁶⁵	12.6	TNRC6A PIK3R3 GSK3B AGO2 AGO1
12	Development HGF signaling pathway ²² Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development Neurotrophin family signaling ²² MET activates PTPN11 ⁶⁵ MET activates STAT3 ⁶⁵ Neurotrophin signaling pathway ³⁶ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.59	RAP1B RAP1A PIK3R3 ITGB1 GSK3B
13	Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling ⁶⁴ Show member pathways Blood-Brain Barrier and Immune Cell Transmigration: CCL2/MCP-1 Signaling ⁶⁴ Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling ⁶⁴ Blood-Brain Barrier and Immune Cell Transmigration: VEGF Signaling ⁶⁴ Leukocyte transendothelial migration ³⁶	12.52	RAP1B RAP1A PIK3R3 PIK3CG ITGB1
14	ErbB signaling pathway ³⁶ ¹ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ³⁶ Renal cell carcinoma ³⁶ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.48	RAP1B RAP1A PIK3R3 PIK3CG GSK3B
15	Cytoskeletal Signaling ⁴	12.43	RAP1B RAP1A ITGB1 DAB2
16	Prolactin Signaling Pathway ³⁶ ¹ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	12.38	PIK3R3 PIK3CG ITGB1 GSK3B
17	B Cell Receptor Signaling Pathway (sino) ⁶⁶ Show member pathways B Cell Receptor Signaling Pathway ⁶⁶	12.34	RAP1B RAP1A PIK3CG GSK3B
18	Apoptosis Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ NF-kappaB Pathway ⁷⁰	12.33	PIK3R3 PIK3CG ITGB1 GSK3B
19	G-protein signaling G-Protein alpha-i signaling cascades ²² Show member pathways Development Beta-adrenergic receptors regulation of ERK ²² G-protein signaling G-Protein alpha-s signaling cascades ²² G-protein signaling G-Protein beta/gamma signaling cascades ²²	12.26	RAP1A PRKACB PIK3CG GSK3B
20	cAMP signaling pathway ³⁶	12.22	RAP1B RAP1A PRKACB PIK3R3
21	AMP-activated Protein Kinase (AMPK) Signaling ¹ Show member pathways AMPK signaling pathway ³⁶ AMPK Signaling Pathway ⁶⁶	12.22	PRKACB PIK3R3 PIK3CG GSK3B ELAVL1
22	Pre-NOTCH Expression and Processing ⁶⁵ Show member pathways Defective LFNG causes SCDO3 ⁶⁵ Notch-HLH transcription pathway ⁶⁵ Post-transcriptional silencing by small RNAs ⁶⁵ Pre-NOTCH Processing in Golgi ⁶⁵ Pre-NOTCH Processing in the Endoplasmic Reticulum ⁶⁵ Pre-NOTCH Transcription and Translation ⁶⁵	11.96	TNRC6A AGO2 AGO1
23	Development A2A receptor signaling ²² Show member pathways Development A2B receptor- action via G-protein alpha s ²²	11.95	RAP1A PRKACB GSK3B
24	Adhesion ⁴	11.94	RAP1B RAP1A ITGB1
25	Thyroid hormone signaling pathway ³⁶	11.92	PRKACB PIK3R3 GSK3B
26	Yersinia infection ³⁶	11.92	PIK3R3 ITGB1 GSK3B
27	DNA Damage Response (only ATM dependent) ¹	11.89	PIK3R3 PIK3CG GSK3B
28	Long-term potentiation ³⁶ Show member pathways Common Pathways Underlying Drug Addiction ¹	11.86	RAP1B RAP1A PRKACB
29	MAPK Pathway ⁷⁰ Show member pathways Toll-like Receptor Pathway ⁷⁰	11.85	PIK3R3 PIK3CG ITGB1 GSK3B
30	PI3K / Akt Signaling ⁴	11.76	PIK3R3 PIK3CG GSK3B
31	Translational Control ⁴	11.72	ZFP36 FXR1 ELAVL1 AGO2 AGO1 ADAR
32	TP53 Regulates Metabolic Genes ⁶⁵	11.7	TNRC6A AGO2 AGO1
33	G-protein signaling_RhoA regulation pathway ²²	11.64	RAP1B RAP1A PRKACB ITGB1
34	Development_Leptin signaling via PI3K-dependent pathway ²²	11.44	PRKACB PIK3R3 GSK3B
35	Platelet activation ³⁶	11.19	RAP1B RAP1A PRKACB PIK3R3 PIK3CG ITGB1
36	Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling ¹	11.1	PIK3CG ITGB1 GSK3B
37	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities ¹	11.06	PIK3R3 PIK3CG GSK3B
38	Reelin signaling pathway ¹	10.96	RAP1A ITGB1 GSK3B
39	G-protein signaling_Rap1B regulation pathway ²²	10.78	RAP1B PRKACB
40	Rap1 signalling ⁶⁵	10.54	RAP1B RAP1A PRKACB

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GO Terms for Cervical Non-Keratinizing Squamous Cell Carcinoma

Cellular components related to Cervical Non-Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:0005737	10.2	ZFP36 TNRC6A RAP1B RAP1A PRKACB PIK3CG
2	cytosol	GO:0005829	10	ZFP36 TNRC6A RAP1B RAP1A PRKACB PIK3R3
3	glutamatergic synapse	GO:0098978	9.77	RAP1A ITGB1 GSK3B FXR1 ELAVL1
4	ribonucleoprotein complex	GO:1990904	9.73	ZFP36 ELAVL1 AGO2 AGO1
5	postsynapse	GO:0098794	9.63	GSK3B FXR1 ELAVL1
6	polysome	GO:0005844	9.58	FXR1 AGO2 AGO1
7	P-body	GO:0000932	9.56	ZFP36 TNRC6A AGO2 AGO1
8	RISC complex	GO:0016442	9.13	TNRC6A AGO2 AGO1
9	RISC-loading complex	GO:0070578	8.8	ZFP36 AGO2 AGO1

Biological processes related to Cervical Non-Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 31)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of apoptotic process	GO:0043066	10	MIR200B GSK3B DAB2 ADAR ADA
2	positive regulation of gene expression	GO:0010628	9.97	TNRC6A PIK3R3 GSK3B AGO2 AGO1
3	negative regulation of gene expression	GO:0010629	9.83	TNRC6A MIR200B MIR106B AGO2 AGO1
4	negative regulation of angiogenesis	GO:0016525	9.82	MIR200B MIR106B AGO1
5	regulation of mRNA stability	GO:0043488	9.81	ZFP36 FXR1 ELAVL1
6	regulation of translation	GO:0006417	9.78	TNRC6A FXR1 AGO2 AGO1
7	regulation of gene silencing by miRNA	GO:0060964	9.75	TNRC6A AGO2 AGO1
8	cellular response to cAMP	GO:0071320	9.7	RAP1B RAP1A PIK3CG
9	cell migration involved in sprouting angiogenesis	GO:0002042	9.65	PIK3R3 ITGB1
10	3'-UTR-mediated mRNA stabilization	GO:0070935	9.64	ZFP36 ELAVL1
11	establishment of endothelial barrier	GO:0061028	9.64	RAP1B RAP1A
12	microvillus assembly	GO:0030033	9.63	RAP1B RAP1A
13	Wnt signaling pathway, calcium modulating pathway	GO:0007223	9.63	TNRC6A AGO2 AGO1
14	miRNA metabolic process	GO:0010586	9.62	AGO2 AGO1
15	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	GO:1900153	9.62	ZFP36 AGO2
16	response to carbohydrate	GO:0009743	9.61	RAP1B RAP1A
17	phosphatidylinositol-3-phosphate biosynthetic process	GO:0036092	9.61	PIK3R3 PIK3CG
18	positive regulation of gene silencing by miRNA	GO:2000637	9.59	ZFP36 FXR1
19	Rap protein signal transduction	GO:0032486	9.58	RAP1B RAP1A
20	production of miRNAs involved in gene silencing by miRNA	GO:0035196	9.58	AGO2 AGO1 ADAR
21	RNA secondary structure unwinding	GO:0010501	9.56	AGO2 AGO1
22	regulation of cell junction assembly	GO:1901888	9.55	RAP1B RAP1A
23	negative regulation of synaptic vesicle exocytosis	GO:2000301	9.54	RAP1B RAP1A
24	pre-miRNA processing	GO:0031054	9.54	AGO2 AGO1 ADAR
25	mRNA cleavage involved in gene silencing by miRNA	GO:0035279	9.51	AGO2 AGO1
26	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	GO:0060213	9.5	ZFP36 TNRC6A AGO2
27	mRNA cleavage involved in gene silencing by siRNA	GO:0090625	9.49	AGO2 AGO1
28	posttranscriptional gene silencing by RNA	GO:0035194	9.43	TNRC6A AGO2 AGO1
29	gene silencing by RNA	GO:0031047	9.35	ZFP36 TNRC6A AGO2 AGO1 ADAR
30	miRNA loading onto RISC involved in gene silencing by miRNA	GO:0035280	9.33	AGO2 AGO1 ADAR
31	miRNA mediated inhibition of translation	GO:0035278	9.1	ZFP36 TNRC6A MIR200B MIR106B AGO2 AGO1

Molecular functions related to Cervical Non-Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	10.36	ZFP36 TNRC6A RAP1B RAP1A PRKACB PIK3R3
2	RNA binding	GO:0003723	9.98	ZFP36 TNRC6A FXR1 ELAVL1 AGO2 AGO1
3	mRNA binding	GO:0003729	9.56	ZFP36 FXR1 ELAVL1 AGO2
4	core promoter sequence-specific DNA binding	GO:0001046	9.48	AGO2 AGO1
5	core promoter binding	GO:0001047	9.4	AGO2 AGO1
6	1-phosphatidylinositol-3-kinase activity	GO:0016303	9.37	PIK3R3 PIK3CG
7	miRNA binding	GO:0035198	9.33	ELAVL1 AGO2 AGO1
8	adenosine deaminase activity	GO:0004000	9.32	ADAR ADA
9	mRNA 3'-UTR binding	GO:0003730	9.26	MIR200B MIR106B FXR1 ELAVL1
10	double-stranded RNA binding	GO:0003725	8.92	ELAVL1 AGO2 AGO1 ADAR

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Sources for Cervical Non-Keratinizing Squamous Cell Carcinoma

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