MCID: CRV020
MIFTS: 23

Cervical Non-Keratinizing Squamous Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervical Non-Keratinizing Squamous Cell Carcinoma

MalaCards integrated aliases for Cervical Non-Keratinizing Squamous Cell Carcinoma:

Name: Cervical Non-Keratinizing Squamous Cell Carcinoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:7961
NCIt 50 C40188
UMLS 70 C1518366

Summaries for Cervical Non-Keratinizing Squamous Cell Carcinoma

Disease Ontology : 12 A cervial squamous cell carcinoma that is characterized by polygonal squamous cells growing in sheets or nests but keratin pearls are not present.

MalaCards based summary : Cervical Non-Keratinizing Squamous Cell Carcinoma is related to cervical keratinizing squamous cell carcinoma. An important gene associated with Cervical Non-Keratinizing Squamous Cell Carcinoma is ADAR (Adenosine Deaminase RNA Specific), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Related phenotypes are cardiovascular system and cellular

Related Diseases for Cervical Non-Keratinizing Squamous Cell Carcinoma

Diseases related to Cervical Non-Keratinizing Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 cervical keratinizing squamous cell carcinoma 9.9 RAP1B PRKACB ADAR

Symptoms & Phenotypes for Cervical Non-Keratinizing Squamous Cell Carcinoma

MGI Mouse Phenotypes related to Cervical Non-Keratinizing Squamous Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.23 ADA ADAR AGO2 ELAVL1 FXR1 GSK3B
2 cellular MP:0005384 10.21 ADA ADAR AGO2 DAB2 ELAVL1 GSK3B
3 growth/size/body region MP:0005378 10.13 ADA ADAR AGO1 AGO2 DAB2 ELAVL1
4 embryo MP:0005380 10.06 ADA ADAR AGO2 DAB2 ELAVL1 ITGB1
5 hematopoietic system MP:0005397 10.03 ADA ADAR AGO2 ELAVL1 FXR1 ITGB1
6 endocrine/exocrine gland MP:0005379 10.02 ADA AGO2 ELAVL1 FXR1 GSK3B ITGB1
7 immune system MP:0005387 9.9 ADA ADAR AGO2 ELAVL1 FXR1 GSK3B
8 mortality/aging MP:0010768 9.86 ADA ADAR AGO1 AGO2 DAB2 ELAVL1
9 muscle MP:0005369 9.23 ADA ELAVL1 FXR1 GSK3B ITGB1 MAPK8

Drugs & Therapeutics for Cervical Non-Keratinizing Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Cervical Non-Keratinizing Squamous Cell Carcinoma

Genetic Tests for Cervical Non-Keratinizing Squamous Cell Carcinoma

Anatomical Context for Cervical Non-Keratinizing Squamous Cell Carcinoma

Publications for Cervical Non-Keratinizing Squamous Cell Carcinoma

Variations for Cervical Non-Keratinizing Squamous Cell Carcinoma

Expression for Cervical Non-Keratinizing Squamous Cell Carcinoma

Search GEO for disease gene expression data for Cervical Non-Keratinizing Squamous Cell Carcinoma.

Pathways for Cervical Non-Keratinizing Squamous Cell Carcinoma

Pathways related to Cervical Non-Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14 TNRC6A RAP1B RAP1A PRKACB PIK3R3 MAPK8
2
Show member pathways
13.29 TNRC6A RAP1B RAP1A PRKACB PIK3R3 ITGB1
3
Show member pathways
13.18 RAP1B RAP1A PIK3R3 PIK3CG MAPK8 GSK3B
4
Show member pathways
12.91 PRKACB PIK3R3 MAPK8 ITGB1 GSK3B
5
Show member pathways
12.89 ZFP36 PRKACB PIK3R3 PIK3CG MAPK8 GSK3B
6
Show member pathways
12.88 PRKACB PIK3R3 MAPK8 ITGB1 GSK3B
7 12.82 PRKACB PIK3R3 MAPK8 ITGB1 GSK3B
8
Show member pathways
12.81 RAP1A PRKACB PIK3R3 MAPK8 ITGB1 GSK3B
9
Show member pathways
12.79 RAP1A PIK3R3 PIK3CG MAPK8 ITGB1
10
Show member pathways
12.77 PRKACB PIK3R3 MAPK8 ITGB1 GSK3B
11
Show member pathways
12.73 PRKACB PIK3R3 PIK3CG MAPK8 GSK3B
12
Show member pathways
12.69 TNRC6A PIK3R3 GSK3B AGO2 AGO1
13
Show member pathways
12.68 RAP1B RAP1A PIK3R3 PIK3CG MAPK8 ITGB1
14
Show member pathways
12.63 RAP1B RAP1A PIK3R3 PIK3CG ITGB1
15
Show member pathways
12.63 RAP1B RAP1A PRKACB PIK3R3 MAPK8 ITGB1
16
Show member pathways
12.62 RAP1B RAP1A PRKACB PIK3R3 PIK3CG MAPK8
17
Show member pathways
12.61 PRKACB PIK3R3 MAPK8 GSK3B
18
Show member pathways
12.6 RAP1B RAP1A PIK3R3 MAPK8 ITGB1 GSK3B
19 12.51 RAP1B RAP1A ITGB1 DAB2
20
Show member pathways
12.5 PIK3R3 PIK3CG MAPK8 GSK3B
21
Show member pathways
12.44 RAP1B RAP1A PIK3R3 PIK3CG MAPK8 GSK3B
22
Show member pathways
12.43 PRKACB PIK3R3 PIK3CG GSK3B ELAVL1
23
Show member pathways
12.42 PIK3R3 PIK3CG MAPK8 ITGB1 GSK3B
24
Show member pathways
12.38 PIK3R3 PIK3CG MAPK8 GSK3B
25 12.37 PIK3R3 MAPK8 ITGB1 GSK3B
26
Show member pathways
12.36 PIK3CG MAPK8 ITGB1 GSK3B
27
Show member pathways
12.36 RAP1A PIK3R3 MAPK8 ITGB1 GSK3B
28
Show member pathways
12.36 RAP1B RAP1A PIK3CG MAPK8 GSK3B
29
Show member pathways
12.34 RAP1A PRKACB PIK3CG GSK3B
30
Show member pathways
12.34 PIK3R3 PIK3CG MAPK8 ITGB1 GSK3B
31 12.3 ZFP36 PRKACB PIK3R3 MAPK8
32 12.21 RAP1B RAP1A PRKACB PIK3R3 MAPK8
33 12.17 RAP1A PRKACB MAPK8 ITGB1
34
Show member pathways
12.14 PIK3R3 PIK3CG MAPK8 GSK3B
35
Show member pathways
12.13 PIK3R3 PIK3CG MAPK8 GSK3B
36
Show member pathways
12.1 RAP1B RAP1A PIK3R3 MAPK8
37 12.04 PIK3R3 MAPK8 ITGB1 GSK3B
38 11.99 PRKACB PIK3R3 GSK3B
39
Show member pathways
11.99 RAP1A PRKACB MAPK8 GSK3B
40
Show member pathways
11.94 PIK3R3 MAPK8 GSK3B
41
Show member pathways
11.94 RAP1B RAP1A PRKACB
42 11.91 PIK3R3 PIK3CG MAPK8 GSK3B
43
Show member pathways
11.87 RAP1A PIK3CG MAPK8
44
Show member pathways
11.86 PIK3R3 PIK3CG MAPK8
45 11.86 PIK3R3 PIK3CG MAPK8
46 11.84 RAP1B MAPK8 GSK3B
47 11.84 PIK3R3 PIK3CG GSK3B
48 11.8 TNRC6A AGO2 AGO1
49
Show member pathways
11.79 PIK3R3 PIK3CG MAPK8
50 11.78 PRKACB MAPK8 GSK3B

GO Terms for Cervical Non-Keratinizing Squamous Cell Carcinoma

Cellular components related to Cervical Non-Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.16 ZFP36 TNRC6A RAP1B RAP1A PRKACB PIK3CG
2 cytosol GO:0005829 9.83 ZFP36 TNRC6A RAP1B RAP1A PRKACB PIK3R3
3 ribonucleoprotein complex GO:1990904 9.71 ZFP36 ELAVL1 AGO2 AGO1
4 P-body GO:0000932 9.62 ZFP36 TNRC6A AGO2 AGO1
5 cytoplasmic ribonucleoprotein granule GO:0036464 9.61 FXR1 AGO2 AGO1
6 polysome GO:0005844 9.54 FXR1 AGO2 AGO1
7 RISC complex GO:0016442 9.33 TNRC6A AGO2 AGO1
8 RISC-loading complex GO:0070578 8.8 ZFP36 AGO2 AGO1

Biological processes related to Cervical Non-Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.93 MIR200B MAPK8 GSK3B DAB2 ADAR ADA
2 positive regulation of gene expression GO:0010628 9.91 TNRC6A PIK3R3 MAPK8 GSK3B AGO2 AGO1
3 negative regulation of gene expression GO:0010629 9.88 TNRC6A MIR200B MIR106B AGO2 AGO1
4 regulation of translation GO:0006417 9.83 TNRC6A FXR1 AGO2 AGO1
5 regulation of mRNA stability GO:0043488 9.81 ZFP36 FXR1 ELAVL1
6 regulation of gene silencing by miRNA GO:0060964 9.77 TNRC6A AGO2 AGO1
7 negative regulation of protein binding GO:0032091 9.76 MAPK8 GSK3B DAB2
8 cellular response to cAMP GO:0071320 9.73 RAP1B RAP1A PIK3CG
9 Wnt signaling pathway, calcium modulating pathway GO:0007223 9.67 TNRC6A AGO2 AGO1
10 establishment of endothelial barrier GO:0061028 9.64 RAP1B RAP1A
11 microvillus assembly GO:0030033 9.63 RAP1B RAP1A
12 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900153 9.62 ZFP36 AGO2
13 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.62 PIK3R3 PIK3CG
14 response to carbohydrate GO:0009743 9.61 RAP1B RAP1A
15 positive regulation of gene silencing by miRNA GO:2000637 9.61 ZFP36 FXR1
16 Rap protein signal transduction GO:0032486 9.6 RAP1B RAP1A
17 regulation of cell junction assembly GO:1901888 9.58 RAP1B RAP1A
18 production of miRNAs involved in gene silencing by miRNA GO:0035196 9.58 AGO2 AGO1 ADAR
19 RNA secondary structure unwinding GO:0010501 9.57 AGO2 AGO1
20 negative regulation of synaptic vesicle exocytosis GO:2000301 9.55 RAP1B RAP1A
21 mRNA cleavage involved in gene silencing by miRNA GO:0035279 9.54 AGO2 AGO1
22 pre-miRNA processing GO:0031054 9.54 AGO2 AGO1 ADAR
23 mRNA cleavage involved in gene silencing by siRNA GO:0090625 9.51 AGO2 AGO1
24 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060213 9.5 ZFP36 TNRC6A AGO2
25 posttranscriptional gene silencing by RNA GO:0035194 9.43 TNRC6A AGO2 AGO1
26 gene silencing by RNA GO:0031047 9.35 ZFP36 TNRC6A AGO2 AGO1 ADAR
27 miRNA loading onto RISC involved in gene silencing by miRNA GO:0035280 9.33 AGO2 AGO1 ADAR
28 miRNA mediated inhibition of translation GO:0035278 9.1 ZFP36 TNRC6A MIR200B MIR106B AGO2 AGO1

Molecular functions related to Cervical Non-Keratinizing Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA binding GO:0003723 9.95 ZFP36 TNRC6A FXR1 ELAVL1 AGO2 AGO1
2 mRNA binding GO:0003729 9.56 ZFP36 FXR1 ELAVL1 AGO2
3 mRNA 3'-UTR binding GO:0003730 9.46 MIR200B MIR106B FXR1 ELAVL1
4 core promoter sequence-specific DNA binding GO:0001046 9.43 AGO2 AGO1
5 adenosine deaminase activity GO:0004000 9.37 ADAR ADA
6 1-phosphatidylinositol-3-kinase activity GO:0016303 9.32 PIK3R3 PIK3CG
7 miRNA binding GO:0035198 9.13 ELAVL1 AGO2 AGO1
8 double-stranded RNA binding GO:0003725 8.92 ELAVL1 AGO2 AGO1 ADAR

Sources for Cervical Non-Keratinizing Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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