Cervical Serous Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Cervical Serous Adenocarcinoma

MalaCards integrated aliases for Cervical Serous Adenocarcinoma:

Name: Cervical Serous Adenocarcinoma ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5752

NCIt ⁴⁹ C40201

UMLS ⁷¹ C1516431

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Summaries for Cervical Serous Adenocarcinoma

Disease Ontology : ¹² A cervical adenocarcinoma that derives from epithelial cells originating in glandular tissue forming serous lesions.

MalaCards based summary : Cervical Serous Adenocarcinoma is related to thymus clear cell carcinoma and testicular granulosa cell tumor. An important gene associated with Cervical Serous Adenocarcinoma is MLANA (Melan-A), and among its related pathways/superpathways are NF-kappaB Signaling and Primary Focal Segmental Glomerulosclerosis FSGS. Affiliated tissues include breast, liver and ovary, and related phenotypes are integument and no phenotypic analysis

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Related Diseases for Cervical Serous Adenocarcinoma

Diseases related to Cervical Serous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)

#	Related Disease	Score	Top Affiliating Genes
1	thymus clear cell carcinoma	10.3	MLANA GATA3
2	testicular granulosa cell tumor	10.3	WT1 MLANA
3	microinvasive cervical squamous cell carcinoma	10.2	WT1 GATA3
4	juvenile type testicular granulosa cell tumor	10.2	WT1 MLANA
5	epithelial predominant wilms' tumor	10.2	WT1 MLANA
6	intravascular fasciitis	10.2	MLANA CTNNB1
7	sarcomatoid squamous cell skin carcinoma	10.2	MME MLANA
8	testicular sex cord-stromal neoplasm	10.2	WT1 MLANA
9	balloon cell malignant melanoma	10.2	MME MLANA
10	epithelioid cell synovial sarcoma	10.2	WT1 GATA3
11	dermis tumor	10.2	MME MLANA
12	microcystic stromal tumor	10.2	WT1 CTNNB1
13	epididymal neoplasm	10.1	WT1 MME
14	kidney benign neoplasm	10.1	MME MLANA
15	anal paget's disease	10.1	MLANA CEACAM5
16	cystadenofibroma	10.1	WT1 MME
17	adenofibroma	10.1	WT1 MME
18	cutaneous fibrous histiocytoma	10.1	MME MLANA
19	renal adenoma	10.1	WT1 MME
20	epididymis adenocarcinoma	10.1	WT1 MME
21	epididymis cancer	10.1	WT1 MME
22	mesenchymal cell neoplasm	10.1	MME MLANA
23	bladder clear cell adenocarcinoma	10.1	WT1 MME
24	cardiovascular cancer	10.1	MME MLANA
25	vascular cancer	10.1	MME MLANA
26	atypical polypoid adenomyoma	10.1	MME CTNNB1
27	borst-jadassohn intraepidermal carcinoma	10.1	MLANA CEACAM5
28	malignant epithelial mesothelioma	10.1	WT1 CEACAM5
29	wilms tumor 5	10.1	WT1 CTNNB1
30	paget disease, extramammary	10.1	MLANA CEACAM5
31	hemorrhoid	10.1	MLANA CEACAM5
32	adrenal cortical carcinoma	10.1	MLANA CTNNB1
33	benign mesothelioma	10.1	WT1 CEACAM5
34	pericardium cancer	10.1	WT1 CEACAM5
35	clear cell sarcoma	10.0	WT1 MLANA
36	classic pulmonary blastoma	10.0	CTNNB1 CEACAM5
37	adrenal cortical adenoma	10.0	MLANA CTNNB1
38	ovarian benign neoplasm	10.0	WT1 CEACAM5
39	liver lymphoma	10.0	MME CEACAM5
40	female urethral cancer	10.0	MME CEACAM5
41	vaginal tubulovillous adenoma	10.0	CTNNB1 CEACAM5
42	vaginal adenoma	10.0	CTNNB1 CEACAM5
43	clear cell hidradenoma	10.0	MME CEACAM5
44	hidradenoma	10.0	MME CEACAM5
45	urethral benign neoplasm	10.0	MME CEACAM5
46	eccrine sweat gland neoplasm	10.0	MME CEACAM5
47	sweat gland neoplasm	10.0	MME CEACAM5
48	peritoneum cancer	10.0	WT1 CEACAM5
49	leukemia, acute lymphoblastic 3	10.0	MME GATA3
50	nasal cavity olfactory neuroblastoma	10.0	MME CEACAM5

Graphical network of the top 20 diseases related to Cervical Serous Adenocarcinoma:

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Symptoms & Phenotypes for Cervical Serous Adenocarcinoma

MGI Mouse Phenotypes related to Cervical Serous Adenocarcinoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument	MP:0010771	9.35	CTNNB1 GATA3 MLANA MME PGR
2	no phenotypic analysis	MP:0003012	9.02	CTNNB1 GATA3 MLANA PGR WT1

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Drugs & Therapeutics for Cervical Serous Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Cervical Serous Adenocarcinoma

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Genetic Tests for Cervical Serous Adenocarcinoma

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Anatomical Context for Cervical Serous Adenocarcinoma

MalaCards organs/tissues related to Cervical Serous Adenocarcinoma:

⁴⁰

Breast, Liver, Ovary, Thymus, Smooth Muscle, Small Intestine, Colon

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Publications for Cervical Serous Adenocarcinoma

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Genes for Cervical Serous Adenocarcinoma

Genes related to Cervical Serous Adenocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MLANA	Melan-A	Protein Coding	4.23	DISEASES inferred ¹⁵
2	GATA3	GATA Binding Protein 3	Protein Coding	3.93	DISEASES inferred ¹⁵
3	WT1	WT1 Transcription Factor	Protein Coding	3.83	DISEASES inferred ¹⁵
4	MME	Membrane Metalloendopeptidase	Protein Coding	3.7	DISEASES inferred ¹⁵
5	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	3.4	DISEASES inferred ¹⁵
6	PGR	Progesterone Receptor	Protein Coding	3.37	DISEASES inferred ¹⁵
7	CTNNB1	Catenin Beta 1	Protein Coding	3.32	DISEASES inferred ¹⁵

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Variations for Cervical Serous Adenocarcinoma

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Expression for Cervical Serous Adenocarcinoma

Search GEO for disease gene expression data for Cervical Serous Adenocarcinoma.

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Pathways for Cervical Serous Adenocarcinoma

Pathways related to Cervical Serous Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	NF-kappaB Signaling ⁴	11.65	MLANA GATA3 CEACAM5
2	Primary Focal Segmental Glomerulosclerosis FSGS ¹	10.67	WT1 MME CTNNB1

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GO Terms for Cervical Serous Adenocarcinoma

Biological processes related to Cervical Serous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	9.84	WT1 PGR GATA3 CTNNB1
2	negative regulation of gene expression	GO:0010629	9.61	PGR GATA3 CTNNB1
3	vasculogenesis	GO:0001570	9.55	WT1 CTNNB1
4	cellular response to cytokine stimulus	GO:0071345	9.52	MME GATA3
5	thymus development	GO:0048538	9.51	GATA3 CTNNB1
6	branching involved in ureteric bud morphogenesis	GO:0001658	9.49	WT1 CTNNB1
7	T cell differentiation	GO:0030217	9.48	GATA3 CTNNB1
8	cell maturation	GO:0048469	9.46	GATA3 CTNNB1
9	T cell differentiation in thymus	GO:0033077	9.4	GATA3 CTNNB1
10	male genitalia development	GO:0030539	9.37	WT1 CTNNB1
11	cell fate determination	GO:0001709	9.32	GATA3 CTNNB1
12	mesenchymal to epithelial transition	GO:0060231	9.26	WT1 GATA3
13	regulation of epithelial cell differentiation	GO:0030856	9.16	GATA3 CTNNB1
14	regulation of nephron tubule epithelial cell differentiation	GO:0072182	8.96	GATA3 CTNNB1
15	kidney development	GO:0001822	8.92	WT1 MME GATA3 CTNNB1

Molecular functions related to Cervical Serous Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA-binding transcription factor activity	GO:0003700	9.26	WT1 PGR GATA3 CTNNB1
2	zinc ion binding	GO:0008270	8.92	WT1 PGR MME GATA3

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Sources for Cervical Serous Adenocarcinoma

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