MCID: CRV011
MIFTS: 24

Cervical Serous Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervical Serous Adenocarcinoma

MalaCards integrated aliases for Cervical Serous Adenocarcinoma:

Name: Cervical Serous Adenocarcinoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5752
NCIt 49 C40201
UMLS 71 C1516431

Summaries for Cervical Serous Adenocarcinoma

Disease Ontology : 12 A cervical adenocarcinoma that derives from epithelial cells originating in glandular tissue forming serous lesions.

MalaCards based summary : Cervical Serous Adenocarcinoma is related to thymus clear cell carcinoma and testicular granulosa cell tumor. An important gene associated with Cervical Serous Adenocarcinoma is MLANA (Melan-A), and among its related pathways/superpathways are NF-kappaB Signaling and Primary Focal Segmental Glomerulosclerosis FSGS. Affiliated tissues include breast, liver and ovary, and related phenotypes are integument and no phenotypic analysis

Related Diseases for Cervical Serous Adenocarcinoma

Diseases related to Cervical Serous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 thymus clear cell carcinoma 10.3 MLANA GATA3
2 testicular granulosa cell tumor 10.3 WT1 MLANA
3 microinvasive cervical squamous cell carcinoma 10.2 WT1 GATA3
4 juvenile type testicular granulosa cell tumor 10.2 WT1 MLANA
5 epithelial predominant wilms' tumor 10.2 WT1 MLANA
6 intravascular fasciitis 10.2 MLANA CTNNB1
7 sarcomatoid squamous cell skin carcinoma 10.2 MME MLANA
8 testicular sex cord-stromal neoplasm 10.2 WT1 MLANA
9 balloon cell malignant melanoma 10.2 MME MLANA
10 epithelioid cell synovial sarcoma 10.2 WT1 GATA3
11 dermis tumor 10.2 MME MLANA
12 microcystic stromal tumor 10.2 WT1 CTNNB1
13 epididymal neoplasm 10.1 WT1 MME
14 kidney benign neoplasm 10.1 MME MLANA
15 anal paget's disease 10.1 MLANA CEACAM5
16 cystadenofibroma 10.1 WT1 MME
17 adenofibroma 10.1 WT1 MME
18 cutaneous fibrous histiocytoma 10.1 MME MLANA
19 renal adenoma 10.1 WT1 MME
20 epididymis adenocarcinoma 10.1 WT1 MME
21 epididymis cancer 10.1 WT1 MME
22 mesenchymal cell neoplasm 10.1 MME MLANA
23 bladder clear cell adenocarcinoma 10.1 WT1 MME
24 cardiovascular cancer 10.1 MME MLANA
25 vascular cancer 10.1 MME MLANA
26 atypical polypoid adenomyoma 10.1 MME CTNNB1
27 borst-jadassohn intraepidermal carcinoma 10.1 MLANA CEACAM5
28 malignant epithelial mesothelioma 10.1 WT1 CEACAM5
29 wilms tumor 5 10.1 WT1 CTNNB1
30 paget disease, extramammary 10.1 MLANA CEACAM5
31 hemorrhoid 10.1 MLANA CEACAM5
32 adrenal cortical carcinoma 10.1 MLANA CTNNB1
33 benign mesothelioma 10.1 WT1 CEACAM5
34 pericardium cancer 10.1 WT1 CEACAM5
35 clear cell sarcoma 10.0 WT1 MLANA
36 classic pulmonary blastoma 10.0 CTNNB1 CEACAM5
37 adrenal cortical adenoma 10.0 MLANA CTNNB1
38 ovarian benign neoplasm 10.0 WT1 CEACAM5
39 liver lymphoma 10.0 MME CEACAM5
40 female urethral cancer 10.0 MME CEACAM5
41 vaginal tubulovillous adenoma 10.0 CTNNB1 CEACAM5
42 vaginal adenoma 10.0 CTNNB1 CEACAM5
43 clear cell hidradenoma 10.0 MME CEACAM5
44 hidradenoma 10.0 MME CEACAM5
45 urethral benign neoplasm 10.0 MME CEACAM5
46 eccrine sweat gland neoplasm 10.0 MME CEACAM5
47 sweat gland neoplasm 10.0 MME CEACAM5
48 peritoneum cancer 10.0 WT1 CEACAM5
49 leukemia, acute lymphoblastic 3 10.0 MME GATA3
50 nasal cavity olfactory neuroblastoma 10.0 MME CEACAM5

Graphical network of the top 20 diseases related to Cervical Serous Adenocarcinoma:



Diseases related to Cervical Serous Adenocarcinoma

Symptoms & Phenotypes for Cervical Serous Adenocarcinoma

MGI Mouse Phenotypes related to Cervical Serous Adenocarcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.35 CTNNB1 GATA3 MLANA MME PGR
2 no phenotypic analysis MP:0003012 9.02 CTNNB1 GATA3 MLANA PGR WT1

Drugs & Therapeutics for Cervical Serous Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Cervical Serous Adenocarcinoma

Genetic Tests for Cervical Serous Adenocarcinoma

Anatomical Context for Cervical Serous Adenocarcinoma

MalaCards organs/tissues related to Cervical Serous Adenocarcinoma:

40
Breast, Liver, Ovary, Thymus, Smooth Muscle, Small Intestine, Colon

Publications for Cervical Serous Adenocarcinoma

Variations for Cervical Serous Adenocarcinoma

Expression for Cervical Serous Adenocarcinoma

Search GEO for disease gene expression data for Cervical Serous Adenocarcinoma.

Pathways for Cervical Serous Adenocarcinoma

Pathways related to Cervical Serous Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.65 MLANA GATA3 CEACAM5
2 10.67 WT1 MME CTNNB1

GO Terms for Cervical Serous Adenocarcinoma

Biological processes related to Cervical Serous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.84 WT1 PGR GATA3 CTNNB1
2 negative regulation of gene expression GO:0010629 9.61 PGR GATA3 CTNNB1
3 vasculogenesis GO:0001570 9.55 WT1 CTNNB1
4 cellular response to cytokine stimulus GO:0071345 9.52 MME GATA3
5 thymus development GO:0048538 9.51 GATA3 CTNNB1
6 branching involved in ureteric bud morphogenesis GO:0001658 9.49 WT1 CTNNB1
7 T cell differentiation GO:0030217 9.48 GATA3 CTNNB1
8 cell maturation GO:0048469 9.46 GATA3 CTNNB1
9 T cell differentiation in thymus GO:0033077 9.4 GATA3 CTNNB1
10 male genitalia development GO:0030539 9.37 WT1 CTNNB1
11 cell fate determination GO:0001709 9.32 GATA3 CTNNB1
12 mesenchymal to epithelial transition GO:0060231 9.26 WT1 GATA3
13 regulation of epithelial cell differentiation GO:0030856 9.16 GATA3 CTNNB1
14 regulation of nephron tubule epithelial cell differentiation GO:0072182 8.96 GATA3 CTNNB1
15 kidney development GO:0001822 8.92 WT1 MME GATA3 CTNNB1

Molecular functions related to Cervical Serous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.26 WT1 PGR GATA3 CTNNB1
2 zinc ion binding GO:0008270 8.92 WT1 PGR MME GATA3

Sources for Cervical Serous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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