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MCID: CRV039
MIFTS: 44

Cervicitis

Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cervicitis

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MalaCards integrated aliases for Cervicitis:

Name: Cervicitis 12 55 15
Uterine Cervicitis 44 73

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:2568
ICD10 33 N72
ICD9CM 35 616.0
MeSH 44 D002575
NCIt 50 C26716
SNOMED-CT 68 37610005 80059007
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Summaries for Cervicitis

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Disease Ontology : 12 A cervix disease that is characterized by inflammation of the cervix.

MalaCards based summary : Cervicitis, also known as uterine cervicitis, is related to acute cervicitis and chronic cervicitis. An important gene associated with Cervicitis is DEFB4A (Defensin Beta 4A), and among its related pathways/superpathways are Allograft rejection and Pathways in cancer. The drugs Doxycycline and Lymecycline have been mentioned in the context of this disorder. Affiliated tissues include cervix, t cells and brain.

Wikipedia : 76 Cervicitis is inflammation of the uterine cervix. Cervicitis in women has many features in common with... more...

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Related Diseases for Cervicitis

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Diseases in the Cervicitis family:

Acute Cervicitis Chronic Cervicitis

Diseases related to Cervicitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1714)
# Related Disease Score Top Affiliating Genes
1 acute cervicitis 33.6 MT-TG SERPIND1
2 chronic cervicitis 33.5 SERPIND1 SLC12A4
3 in situ carcinoma 31.8 CDKN2A SERPIND1
4 cervix uteri carcinoma in situ 31.8 CDKN2A SERPIND1
5 squamous cell papilloma 30.5 CDKN2A HSPD1
6 necrotizing fasciitis 30.4 CXCL8 IL2
7 vaginitis 30.2 CXCL8 DEFB4A
8 bacterial vaginosis 30.1 CXCL8 DEFB4A
9 trichomoniasis 29.7 CXCL8 IL2
10 urethritis 29.7 DEFB4A HSPD1 MRAP MT-TG YME1L1
11 brucellosis 29.6 CXCL8 IL2 IL2RA
12 tonsillitis 29.5 CXCL8 DEFB4A IL2
13 mycobacterium fortuitum 29.4 CXCL8 HSPD1
14 septic arthritis 29.4 CXCL8 DEFB4A
15 vaginal disease 29.4 CXCL8 DEFB4A
16 vulvovaginitis 29.3 CXCL8 HSPD1
17 intermediate uveitis 29.3 IL2 IL2RA
18 bacterial infectious disease 29.2 CXCL8 DEFB4A HSPD1
19 myeloma, multiple 29.1 CDKN2A CXCL8 IL2
20 adult t-cell leukemia 29.1 CDKN2A IL2 IL2RA
21 streptococcal toxic-shock syndrome 29.1 CXCL8 IL2
22 periodontal disease 29.0 CXCL8 DEFB4A HSPD1
23 sinusitis 29.0 CXCL8 DEFB4A
24 pyuria 28.9 CXCL8 MRAP
25 dermatitis, atopic 28.7 CXCL8 DEFB4A IL2 IL2RA
26 behcet syndrome 28.4 CXCL8 HSPD1 IL2 IL2RA MRAP
27 cervical cancer 12.6
28 cervical rib 12.4
29 cervical dystonia 12.4
30 cervical intraepithelial neoplasia 12.3
31 cervical polyp 12.3
32 cervical carcinosarcoma 12.3
33 acute gonococcal cervicitis 12.3
34 cervical adenosarcoma 12.3
35 cervical adenosquamous carcinoma 12.2
36 cervical clear cell adenocarcinoma 12.2
37 cervical verrucous carcinoma 12.2
38 cervical adenoma malignum 12.2
39 early invasive cervical adenocarcinoma 12.2
40 isolated anterior cervical hypertrichosis 12.2
41 microinvasive cervical squamous cell carcinoma 12.2
42 microcephaly with cervical spine fusion anomalies 12.2
43 cervical adenofibroma 12.2
44 midline cervical cleft 12.2
45 cervical squamous cell carcinoma 12.1
46 cervical adenocarcinoma 12.1
47 cervical mucinous adenocarcinoma 12.1
48 cervical wilms' tumor 12.1
49 cervical keratinizing squamous cell carcinoma 12.1
50 cervical mullerian papilloma 12.1

Graphical network of the top 20 diseases related to Cervicitis:



Diseases related to Cervicitis
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Symptoms & Phenotypes for Cervicitis

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Drugs & Therapeutics for Cervicitis

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Drugs for Cervicitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
3
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
4
Azithromycin Approved Phase 4,Phase 3,Not Applicable 83905-01-5 55185 447043
5
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
6 Antimalarials Phase 4
7 Antibiotics, Antitubercular Phase 4
8 Antiparasitic Agents Phase 4,Phase 2
9 Antiprotozoal Agents Phase 4,Phase 2
10 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
11 Anti-Bacterial Agents Phase 4,Phase 3,Not Applicable
12
Cefixime Approved, Investigational Phase 3,Not Applicable 79350-37-1 5362065 54362
13
Metronidazole Approved Phase 2 443-48-1 4173
14
Ceftriaxone Approved 73384-59-5 5479530 5361919

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
2 Periodical Presumptive Treatment for the Control of Gonococcal Infections Among Sex Workers Completed NCT01329588 Phase 4 Monthly antibiotic;Monthly placebo
3 Empiric Therapy of Mucopurulent Cervicitis (MPC) Terminated NCT01072136 Phase 3 Azithromycin;Cefixime
4 Metronidazole for Pulmonary Tuberculosis (South Korea) Completed NCT00425113 Phase 2 Metronidazole
5 "Performance of HPV DNA Test in Presence of Co-infection With Common RTIs" Unknown status NCT02830230 Not Applicable Tab cefixime,Tab Azithromycin
6 Chlamydia Trachomatis Immunology and Vaccinology Study Completed NCT01150747 ceftriaxone;Azithromycin
7 Maternal and Perinatal Outcome in Women With History of Premature Labor in Previous Pregnancy Completed NCT01375439 Not Applicable
8 The Role of Novel Organisms in Acute Endometritis Completed NCT01236131

Search NIH Clinical Center for Cervicitis

Cochrane evidence based reviews: uterine cervicitis

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Genetic Tests for Cervicitis

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Anatomical Context for Cervicitis

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MalaCards organs/tissues related to Cervicitis:

41
Cervix, T Cells, Brain, Bone, Testes, Spinal Cord, Thyroid
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Publications for Cervicitis

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Articles related to Cervicitis:

(show top 50) (show all 366)
# Title Authors Year
1
Identifying acute cervicitis in an era of less-frequent routine gynecologic examinations. ( 29369931 )
2018
2
Ligneous cervicitis and endometritis: A gynaecological presentation of congenital plasminogen deficiency. ( 29436075 )
2018
3
An integrative investigation of the therapeutic mechanism of Ainsliaea fragrans Champ. in cervicitis using liquid chromatography tandem mass spectrometry based on a rat plasma metabolomics strategy. ( 29729635 )
2018
4
Comparative Metabolomics Analysis of Cervicitis in Human Patients and a Phenol Mucilage-Induced Rat Model Using Liquid Chromatography Tandem Mass Spectrometry. ( 29670527 )
2018
5
Efficacy and safety of combined high-dose interferon and red light therapy for the treatment of human papillomavirus and associated vaginitis and cervicitis: A prospective and randomized clinical study. ( 30213012 )
2018
6
The Additive Value of Pelvic Examinations to History in Predicting Sexually Transmitted Infections for Young Female Patients With Suspected Cervicitis or Pelvic Inflammatory Disease. ( 30251627 )
2018
7
Clinical efficacy of cryotherapy combined with interferon in the treatment of chronic cervicitis complicated with HPV infection. ( 29044006 )
2017
8
Effect of Dialyzable Leukocyte Extract on chronic cervicitis in patients with HPV infection. ( 29362599 )
2017
9
Chronic Cervicitis. ( 28232137 )
2017
10
Tuberculous cervicitis: A brief report with cytohistological correlation and differential diagnosis. ( 28891141 )
2017
11
Cystic Cervicitis: A Case Report and Literature Review of Cystic Cervical Lesions. ( 27331927 )
2016
12
Cervicitis: a prospective observational study of empiric azithromycin treatment in women with cervicitis and non-specific cervicitis. ( 26792283 )
2016
13
Histological Evidence of Chronic Mycoplasma genitalium-Induced Cervicitis in HIV-Infected Women: A Retrospective Cohort Study. ( 26783349 )
2016
14
Cervicitis aetiology and case definition: a study in Australian women attending sexually transmitted infection clinics. ( 26586777 )
2016
15
Chronic Cervicitis: Presenting Features and Response to Therapy. ( 27243142 )
2016
16
Cytopathological Examination and Epidemiological Study of Cervicitis in Commercial Sex Workers (CSWs) in Coal City (Enugu), Nigeria. ( 26633925 )
2015
17
Metabolomics analysis of cervical cancer, cervical intraepithelial neoplasia and chronic cervicitis by 1H NMR spectroscopy. ( 26050356 )
2015
18
Up-Regulation of miR-21 Is Associated with Cervicitis and Human Papillomavirus Infection in Cervical Tissues. ( 26010154 )
2015
19
Herpes Simplex Virus Cervicitis Mimicking Preterm Premature Rupture of Membranes. ( 25923023 )
2015
20
Relationship of Specific Bacteria in the Cervical and Vaginal Microbiotas With Cervicitis. ( 26267872 )
2015
21
Association between the human papillomavirus, bacterial vaginosis and cervicitis and the detection of abnormalities in cervical smears from teenage girls and young women. ( 26173042 )
2015
22
Prevalence of cervicitis in dairy cows and its effect on reproduction. ( 26483309 )
2015
23
Screening for Chlamydia and Gonorrhea Cervicitis and Implications for Pregnancy Outcome. Are We Testing and Treating at the Right Time? ( 26380488 )
2015
24
Cervicitis: How Often Is It Non-specific! ( 25954624 )
2015
25
Cervicitis of unknown etiology. ( 24859465 )
2014
26
Detection of human papillomavirus in chronic cervicitis, cervical adenocarcinoma, intraepithelial neoplasia and squamus cell carcinoma. ( 25147721 )
2014
27
High bacterial loads of Ureaplasma may be associated with non-specific cervicitis. ( 25017795 )
2014
28
Disseminated herpes simplex virus manifesting as pyrexia and cervicitis and leading to reactive hemophagocytic syndrome in pregnancy. ( 24890680 )
2014
29
Amoebic cervicitis mimicking posterior wall fibroid: a rare presentation. ( 22743593 )
2014
30
Diagnosis of tuberculous cervicitis by Papanicolaou-stained smear. ( 22634489 )
2013
31
Ligneous cervicitis in a woman with plasminogen deficiency associated with an atypical form of microglandular hyperplasia: a case report and review of literature. ( 23518917 )
2013
32
Much is still unknown about cervicitis of unknown etiology. ( 23584805 )
2013
33
Accuracy and false-positive rate of the cytologic diagnosis of follicular cervicitis: observations from the College of American Pathologists Pap Educational Program. ( 23808462 )
2013
34
Prevalence and treatment outcome of cervicitis of unknown etiology. ( 23588127 )
2013
35
Torque teno mini virus infection in chronic cervicitis and cervical tumors in Isfahan, Iran. ( 23689906 )
2013
36
Human I^-defensin messenger RNA is overexpressed in the cervical epithelia of patients with nongonococcal cervicitis. ( 23774076 )
2013
37
Acute cervicitis and vulvovaginitis may be associated with Cytomegalovirus. ( 23606387 )
2013
38
Clinical and microscopic signs of cervicitis and urethritis: correlation with Chlamydia trachomatis infection in female STI patients. ( 23460336 )
2013
39
Human papillomavirus genotypes associated with mucopurulent cervicitis and cervical cancer in Hangzhou, China. ( 23886152 )
2013
40
Prevalence and predictors of cervicitis in female sex workers in Peru: an observational study. ( 23631602 )
2013
41
Cervicitis: limited clinical utility for the detection of Mycoplasma genitalium in a cross-sectional study of women attending a New Zealand sexual health clinic. ( 23702105 )
2013
42
Detection of human papillomavirus genotypes associated with mucopurulent cervicitis and cervical cancer in Changchun, China. ( 23245674 )
2013
43
Apparent Rarity of Asymptomatic Herpes Cervicitis in a Woman with Intra-Uterine Contraceptive Device. ( 28299103 )
2013
44
Urethritis/cervicitis pathogen prevalence and associated risk factors among asymptomatic HIV-infected patients in South Africa. ( 22706215 )
2012
45
Cervicitis associated with lateral cervical displacement. ( 22055917 )
2012
46
Laboratory-confirmed gonorrhea and/or chlamydia rates in clinically diagnosed pelvic inflammatory disease and cervicitis. ( 22030186 )
2012
47
Discussion: 'Mycoplasma genitalium in cervicitis and pelvic inflammatory disease' by Bjartling et al. ( 22631868 )
2012
48
Detection of torque teno midi virus/small anellovirus (TTMDV/SAV) in chronic cervicitis and cervical tumors in Isfahan, Iran. ( 22086157 )
2012
49
Mycoplasma genitalium in cervicitis and pelvic inflammatory disease among women at a gynecologic outpatient service. ( 22483084 )
2012
50
Cytological diagnosis of tuberculous cervicitis: A case report with review of literature. ( 22438630 )
2012
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Variations for Cervicitis

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Expression for Cervicitis

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Search GEO for disease gene expression data for Cervicitis.
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Pathways for Cervicitis

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Pathways related to Cervicitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Allograft rejection 1 37
Show member pathways
 12.36 CXCL8 HSPD1 IL2 IL2RA
2
Pathways in cancer 37
11.98 CDKN2A CXCL8 IL2 IL2RA
3
Human T-cell leukemia virus 1 infection 37
11.95 CDKN2A IL2 IL2RA
4
Th2 Differentiation Pathway 65
11.07 IL2 IL2RA
5
Inflammatory Response Pathway 1
10.78 IL2 IL2RA
6
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 10.68 CXCL8 IL2 IL2RA
7
IL12 signaling mediated by STAT4 1
10.6 IL2 IL2RA
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GO Terms for Cervicitis

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Biological processes related to Cervicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.73 CXCL8 DEFB4A IL2 IL2RA
2 chemotaxis GO:0006935 9.58 CXCL8 DEFB4A SERPIND1
3 positive regulation of interferon-gamma production GO:0032729 9.48 HSPD1 IL2
4 positive regulation of activated T cell proliferation GO:0042104 9.46 IL2 IL2RA
5 apoptotic mitochondrial changes GO:0008637 9.37 CDKN2A HSPD1
6 positive regulation of T cell differentiation GO:0045582 9.32 IL2 IL2RA
7 regulation of regulatory T cell differentiation GO:0045589 9.26 IL2 IL2RA
8 interleukin-2-mediated signaling pathway GO:0038110 9.16 IL2 IL2RA
9 negative regulation of lymphocyte proliferation GO:0050672 8.96 IL2 IL2RA
10 regulation of T cell homeostatic proliferation GO:0046013 8.62 IL2 IL2RA
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Sources for Cervicitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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