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MCID: CRV039
MIFTS: 49

Cervicitis

Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cervicitis

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MalaCards integrated aliases for Cervicitis:

Name: Cervicitis 12 55 15
Uterine Cervicitis 44 73

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 33


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Summaries for Cervicitis

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MalaCards based summary : Cervicitis, also known as uterine cervicitis, is related to chronic cervicitis and cervix uteri carcinoma in situ. An important gene associated with Cervicitis is DEFB4A (Defensin Beta 4A), and among its related pathways/superpathways are HTLV-I infection and Th2 Differentiation Pathway. The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, lymph node and testes, and related phenotypes are hematopoietic system and liver/biliary system

Wikipedia : 76 Cervices is inflammation of the uterine cervix. Cervicitis in women has many features in common with... more...

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Related Diseases for Cervicitis

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Diseases in the Cervicitis family:

Acute Cervicitis Chronic Cervicitis

Diseases related to Cervicitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1452)
# Related Disease Score Top Affiliating Genes
1 chronic cervicitis 33.5 SERPIND1 SLC12A4
2 cervix uteri carcinoma in situ 32.7 CDKN2A SERPIND1
3 in situ carcinoma 31.6 CDKN2A SERPIND1
4 trichomoniasis 30.4 CD79A IL2
5 salpingitis 30.1 CD79A HSPD1
6 intermediate uveitis 29.8 IL2 IL2RA
7 chronic graft versus host disease 29.6 CD79A IL2RA
8 vaginal disease 29.6 DEFB4A FLNA
9 erythema multiforme 29.5 CD79A IL2
10 combined immunodeficiency, x-linked 29.4 CD79A IL2 IL2RA
11 brucellosis 29.3 IL2 IL2RA
12 tetanus 29.2 CD79A IL2 IL2RA
13 periodontal disease 29.1 CD79A DEFB4A HSPD1
14 adult t-cell leukemia 29.1 CDKN2A IL2 IL2RA
15 acute salpingitis 29.0 CD79A MRAP
16 myeloma, multiple 28.9 CD79A CDKN2A IL2
17 reactive arthritis 28.7 CD79A HSPD1
18 cervix disease 28.2 CD79A CDKN2A FLNA MRAP MT-TG SERPIND1
19 urethritis 28.1 CD79A DEFB4A HSPD1 MRAP MT-TG
20 cervical cancer 12.4
21 cervical dystonia 12.2
22 cervical rib 12.2
23 cervical intraepithelial neoplasia 12.2
24 cervical polyp 12.1
25 cervical adenosarcoma 12.1
26 cervical adenosquamous carcinoma 12.1
27 isolated anterior cervical hypertrichosis 12.1
28 microcephaly with cervical spine fusion anomalies 12.0
29 midline cervical cleft 12.0
30 cervical squamous cell carcinoma 12.0
31 cervical adenocarcinoma 12.0
32 cervical wilms' tumor 12.0
33 cervical carcinosarcoma 11.9
34 cervical adenitis 11.9
35 cervical incompetence 11.9
36 cervical alveolar soft part sarcoma 11.9
37 glassy cell variant cervical adenosquamous carcinoma 11.9
38 cervical hypertrichosis peripheral neuropathy 11.9
39 acute gonococcal cervicitis 11.9
40 cervical adenoid cystic carcinoma 11.9
41 acute cervicitis 11.9
42 klippel-feil syndrome 11.9
43 cervical clear cell adenocarcinoma 11.9
44 cervical verrucous carcinoma 11.9
45 cervical adenoma malignum 11.9
46 early invasive cervical adenocarcinoma 11.9
47 congenital cervical spinal stenosis 11.9
48 hypertrichosis, anterior cervical 11.9
49 cervical ribs, sprengel anomaly, anal atresia, and urethral obstruction 11.9
50 microinvasive cervical squamous cell carcinoma 11.9

Graphical network of the top 20 diseases related to Cervicitis:



Diseases related to Cervicitis
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Symptoms & Phenotypes for Cervicitis

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MGI Mouse Phenotypes related to Cervicitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CD79A CDKN2A FLNA IL2 IL2RA SERPIND1
2 liver/biliary system MP:0005370 9.35 CD79A CDKN2A FLNA IL2 SLC12A4
3 respiratory system MP:0005388 9.02 CDKN2A FLNA IL2 IL2RA SLC12A4
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Drugs & Therapeutics for Cervicitis

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Drugs for Cervicitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3,Not Applicable 83905-01-5 55185 447043
2
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
3
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
4
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
5
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
6 Anti-Bacterial Agents Phase 4,Phase 3,Not Applicable
7 Antibiotics, Antitubercular Phase 4
8 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
9 Antimalarials Phase 4
10 Antiparasitic Agents Phase 4,Phase 2
11 Antiprotozoal Agents Phase 4,Phase 2
12
Cefixime Approved, Investigational Phase 3,Not Applicable 79350-37-1 54362 5362065
13
Metronidazole Approved Phase 2 443-48-1 4173
14
Ceftriaxone Approved 73384-59-5 5479530 5361919

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
2 Periodical Presumptive Treatment for the Control of Gonococcal Infections Among Sex Workers Completed NCT01329588 Phase 4 Monthly antibiotic;Monthly placebo
3 Empiric Therapy of Mucopurulent Cervicitis (MPC) Terminated NCT01072136 Phase 3 Azithromycin;Cefixime
4 Metronidazole for Pulmonary Tuberculosis (South Korea) Completed NCT00425113 Phase 2 Metronidazole
5 "Performance of HPV DNA Test in Presence of Co-infection With Common RTIs" Unknown status NCT02830230 Not Applicable Tab cefixime,Tab Azithromycin
6 Chlamydia Trachomatis Immunology and Vaccinology Study Completed NCT01150747 ceftriaxone;Azithromycin
7 Maternal and Perinatal Outcome in Women With History of Premature Labor in Previous Pregnancy Completed NCT01375439 Not Applicable
8 The Role of Novel Organisms in Acute Endometritis Completed NCT01236131

Search NIH Clinical Center for Cervicitis

Cochrane evidence based reviews: uterine cervicitis

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Genetic Tests for Cervicitis

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Anatomical Context for Cervicitis

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MalaCards organs/tissues related to Cervicitis:

41
Spinal Cord, Lymph Node, Testes, Cervix, Thyroid, Breast, Bone
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Publications for Cervicitis

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Articles related to Cervicitis:

(show top 50) (show all 14040)
# Title Authors Year
1
Usefulness of the maximum standardized uptake value for the diagnosis and staging of patients with cervical cancer undergoing positron emission tomography/computed tomography. ( 29443749 )
2018
2
The effect of upper instrumented vertebra level on cervical sagittal alignment in Lenke 1 adolescent idiopathic scoliosis. ( 29933123 )
2018
3
Non-steroidal anti-inflammatory agents to induce regression and prevent the progression of cervical intraepithelial neoplasia. ( 29431861 )
2018
4
First case of cervical epidural abscess caused by brucellosis in Saudi Arabia: A case report and literature review. ( 29682450 )
2018
5
Long-term outcomes of postoperative taxane/platinum chemotherapy for early stage cervical cancer: a retrospective study. ( 29446043 )
2018
6
Long non-coding RNA HOTAIR and STAT3 synergistically regulate the cervical cancer cell migration and invasion. ( 29572071 )
2018
7
Congenital cervical kyphosis in an infant with Ehlers-Danlos syndrome. ( 29450629 )
2018
8
INTEREST IN CD2, a global patient-centred study of long-term cervical dystonia treatment with botulinum toxin. ( 29270685 )
2018
9
Comparison of the clinical effects of zero-profile anchored spacer (ROI-C) and conventional cage-plate construct for the treatment of noncontiguous bilevel of cervical degenerative disc disease (CDDD): A minimum 2-year follow-up. ( 29384883 )
2018
10
Cervical lymph node metastases in salivary gland adenoid cystic carcinoma: a systematic review and meta-analysis. ( 29970966 )
2018
11
SOX17 restrains proliferation and tumor formation by down-regulating activity of the Wnt/I^-catenin signaling pathway via trans-suppressing I^-catenin in cervical cancer. ( 29970906 )
2018
12
Tonsillar antimicrobial peptide (AMP) expression profiles of periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) patients. ( 29859567 )
2018
13
Natural History of Cervical Degenerative Spondylolisthesis. ( 29952882 )
2018
14
Risks of cervical intraepithelial neoplasia grade 3 or invasive cancers in ASCUS women with different management: a population-based cohort study. ( 29770625 )
2018
15
Intramuscular fat is present in cervical multifidus but not soleus in patients with chronic whiplash associated disorders. ( 29795590 )
2018
16
Definitive chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil (DCF-R) for advanced cervical esophageal cancer. ( 29948480 )
2018
17
Effectiveness of percutaneous neuromuscular electrical stimulation for neck pain relief in patients with cervical spondylosis. ( 29952946 )
2018
18
The Difference in Cervical Vertebral Skeletal Maturation between Cleft Lip/Palate and Non-Cleft Lip/Palate Orthodontic Patients. ( 29619373 )
2018
19
Cervical spine surgery for tandem spinal stenosis: The impact on low back pain. ( 29408772 )
2018
20
Treatment of single maxillary gingival recession associated with non-carious cervical lesion: Randomized clinical trial comparing connective tissue graft alone to graft plus partial restoration. ( 29681059 )
2018
21
Diagnosis and Incidence of Spondylosis and Cervical Disc Disorders in the University Clinical Hospital in Olsztyn, in Years 2011-2015. ( 29770333 )
2018
22
Upregulation of Long Non-Coding RNA Small Nucleolar RNA Host Gene 12 Contributes to Cell Growth and Invasion in Cervical Cancer by Acting as a Sponge for MiR-424-5p. ( 29533945 )
2018
23
Toll-like receptor variants and cervical Atopobium vaginae infection in women with pelvic inflammatory disease. ( 29286178 )
2018
24
Biomechanics of coupled motion in the cervical spine during simulated whiplash in patients with pre-existing cervical or lumbar spinal fusion: A Finite Element Study. ( 29330341 )
2018
25
Whiplash injury results in sustained impairments of cervical muscle function: A one-year prospective, controlled study. ( 29767228 )
2018
26
A prospective study on the predictive value of DNA methylation in cervical intraepithelial neoplasia prognosis. ( 29971561 )
2018
27
ROS-Mediated Mitochondrial Pathway is Required for <i>Manilkara Zapota</i> (L.) P. Royen Leaf Methanol Extract Inducing Apoptosis in the Modulation of Caspase Activation and EGFR/NF-<i>I_</i>B Activities of HeLa Human Cervical Cancer Cells. ( 29977314 )
2018
28
A rare case of spinal cord compression due to cervical spine metastases from paraganglioma of the jugular foramen-how should it be treated? ( 29423169 )
2018
29
High proportion of abnormal pap smear tests and cervical dysplasia in women with cystic fibrosis. ( 29245055 )
2018
30
The dawn of novel STI prevention methods: modelling potential unintended effects of changes in cervical cancer screening guidelines on trichomoniasis. ( 29545472 )
2018
31
Cervical ganglioneuroblastoma in a new born Japanese Black calf. ( 29526867 )
2018
32
Ultrasound features of extranodal extension in the metastatic cervical lymph nodes of papillary thyroid cancer: a case-control study. ( 29951341 )
2018
33
What is the superior surgical strategy for bi-level cervical spondylosis-anterior cervical disc replacement or anterior cervical decompression and fusion?: A meta-analysis from 11 studies. ( 29595628 )
2018
34
Radiation-induced leiomyosarcoma of the rectum after cervical cancer treatment. ( 29439826 )
2018
35
Cervical necrotizing fasciitis: Systematic review and analysis of 1235 reported cases from the literature. ( 29934952 )
2018
36
Solitary anterior osteochondroma of cervical spine: An unusual cause of dysphagia and review of literature. ( 29928094 )
2018
37
Cervical cancer screening among transactional female sex workers in the Dominican Republic. ( 29966506 )
2018
38
Sensory Trick in a Patient with Cervical Dystonia: Insights from Magnetoencephalography. ( 29565281 )
2018
39
Successful hemostatic management of major surgery for cervical spondylotic myelopathy in a patient with severe factor XI deficiency. ( 29713955 )
2018
40
Occipital neuralgia associates with high cervical spinal cord lesions in idiopathic inflammatory demyelinating disease. ( 29629601 )
2018
41
Effect of Manual Caudal and Downward Displacement of Lower Cervical Adipose Tissue on Laryngoscopic Grade of Patients with Morbid Obesity. ( 29868457 )
2018
42
Cervical spinal cord compression in infants with achondroplasia: should neuroimaging be routine? ( 29872110 )
2018
43
Coexistence of Cervical Leiomyosarcoma and Gastric-Type Adenocarcinoma In Situ with Extensive Extension to the Endometrium and Fallopian Tube. ( 29670794 )
2018
44
Cervical Tracheal Resection and Anastomosis for Postintubation Tracheal Stenosis. ( 29742573 )
2018
45
Cervical spine fractures in osteopetrosis: a case report and review of the literature. ( 29353820 )
2018
46
Utility of p16 Immunohistochemistry in Evaluating Negative Cervical Biopsies Following High-risk Pap Test Results. ( 29112019 )
2018
47
Cervical disc arthroplasty with Prestige-LP for the treatment of contiguous 2-level cervical degenerative disc disease: 5-year follow-up results. ( 29369186 )
2018
48
12 years' preservation of maxillary permanent incisors with cervical root fractures adjacent to aggressive periodontitis: Report of a case. ( 29786703 )
2018
49
Cervical Adenocarcinoma: A Comparison of the Reproducibility of the World Health Organization 2003 and 2014 Classifications. ( 29474242 )
2018
50
Isolated Cervical Cord Involvement in Primary Central Nervous System Vasculitis. ( 29961677 )
2018
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Variations for Cervicitis

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Expression for Cervicitis

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Search GEO for disease gene expression data for Cervicitis.
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Pathways for Cervicitis

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Pathways related to Cervicitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
HTLV-I infection 37
11.84 CDKN2A IL2 IL2RA
2
Th2 Differentiation Pathway 65
10.98 IL2 IL2RA
3
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
10.86 CD79A IL2 IL2RA
4
Inflammatory Response Pathway 1
10.67 IL2 IL2RA
5
IL12 signaling mediated by STAT4 1
10.4 IL2 IL2RA
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GO Terms for Cervicitis

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Biological processes related to Cervicitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein stabilization GO:0050821 9.58 CDKN2A FLNA HSPD1
2 positive regulation of interferon-gamma production GO:0032729 9.49 HSPD1 IL2
3 B cell proliferation GO:0042100 9.48 CD79A HSPD1
4 B cell activation GO:0042113 9.46 CD79A HSPD1
5 positive regulation of activated T cell proliferation GO:0042104 9.43 IL2 IL2RA
6 apoptotic mitochondrial changes GO:0008637 9.37 CDKN2A HSPD1
7 positive regulation of T cell differentiation GO:0045582 9.32 IL2 IL2RA
8 regulation of regulatory T cell differentiation GO:0045589 9.26 IL2 IL2RA
9 interleukin-2-mediated signaling pathway GO:0038110 9.16 IL2 IL2RA
10 negative regulation of lymphocyte proliferation GO:0050672 8.96 IL2 IL2RA
11 regulation of T cell homeostatic proliferation GO:0046013 8.62 IL2 IL2RA
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Sources for Cervicitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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