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MCID: CRV039
MIFTS: 43

Cervicitis

Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cervicitis

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MalaCards integrated aliases for Cervicitis:

Name: Cervicitis 12 56 15
Uterine Cervicitis 45 74

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:2568
ICD9CM 36 616.0
MeSH 45 D002575
NCIt 51 C26716
SNOMED-CT 69 37610005 80059007
ICD10 34 N72
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Summaries for Cervicitis

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Disease Ontology : 12 A cervix disease that is characterized by inflammation of the cervix.

MalaCards based summary : Cervicitis, also known as uterine cervicitis, is related to acute cervicitis and chronic cervicitis. An important gene associated with Cervicitis is DEFB4A (Defensin Beta 4A), and among its related pathways/superpathways are Human T-cell leukemia virus 1 infection and Photodynamic therapy-induced AP-1 survival signaling.. The drugs Lymecycline and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include cervix, testes and t cells, and related phenotype is mortality/aging.

Wikipedia : 77 Cervicitis is inflammation of the uterine cervix. Cervicitis in women has many features in common with... more...

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Related Diseases for Cervicitis

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Diseases in the Cervicitis family:

Acute Cervicitis Chronic Cervicitis

Diseases related to Cervicitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1813)
# Related Disease Score Top Affiliating Genes
1 acute cervicitis 33.7 MT-TG SERPIND1
2 chronic cervicitis 32.9 GP6 SERPIND1 SLC12A4
3 cervix disease 32.2 CDKN2A GP6 SERPIND1
4 in situ carcinoma 32.0 CDKN2A SERPIND1
5 cervix uteri carcinoma in situ 31.4 CDKN2A GP6 SERPIND1
6 squamous cell papilloma 30.9 CDKN2A HSPD1
7 anogenital venereal wart 30.4 CDKN2A GP6
8 brucellosis 30.1 IL2 IL2RA
9 tonsillitis 29.8 DEFB4A IL2
10 intermediate uveitis 29.5 IL2 IL2RA
11 mumps 29.4 IL2 IL2RA
12 urethritis 29.4 DEFB4A HSPD1 MRAP MT-TG YME1L1
13 autoimmune disease 29.4 HSPD1 IL2 IL2RA
14 adult t-cell leukemia 29.1 CDKN2A IL2 IL2RA
15 uterine anomalies 28.8 CDKN2A GP6 SERPIND1
16 behcet syndrome 28.7 HSPD1 IL2 IL2RA MRAP
17 cervical cancer 12.6
18 cervical rib 12.4
19 cervical intraepithelial neoplasia 12.4
20 cervical dystonia 12.4
21 cervical polyp 12.3
22 cervical carcinosarcoma 12.3
23 acute gonococcal cervicitis 12.3
24 cervical adenosarcoma 12.3
25 cervical adenosquamous carcinoma 12.3
26 cervical clear cell adenocarcinoma 12.3
27 cervical verrucous carcinoma 12.2
28 cervical adenoma malignum 12.2
29 early invasive cervical adenocarcinoma 12.2
30 isolated anterior cervical hypertrichosis 12.2
31 cervical mucinous adenocarcinoma 12.2
32 microinvasive cervical squamous cell carcinoma 12.2
33 microcephaly with cervical spine fusion anomalies 12.2
34 cervical adenofibroma 12.2
35 midline cervical cleft 12.2
36 cervical squamous cell carcinoma 12.2
37 cervical adenocarcinoma 12.2
38 cervical wilms' tumor 12.2
39 cervical endometrioid adenocarcinoma 12.1
40 cervical basaloid squamous cell carcinoma 12.1
41 cervical keratinizing squamous cell carcinoma 12.1
42 villoglandular variant cervical mucinous adenocarcinoma 12.1
43 cervical mullerian papilloma 12.1
44 cervical incompetence 12.1
45 cervical adenitis 12.1
46 cervical alveolar soft part sarcoma 12.1
47 cervical serous adenocarcinoma 12.1
48 signet ring cell variant cervical mucinous adenocarcinoma 12.1
49 cervical lymphoepithelioma-like carcinoma 12.1
50 endocervical type cervical adenomyoma 12.1

Graphical network of the top 20 diseases related to Cervicitis:



Diseases related to Cervicitis
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Symptoms & Phenotypes for Cervicitis

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MGI Mouse Phenotypes related to Cervicitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.23 CDKN2A GP6 HSPD1 IL2 IL2RA SERPIND1
Sources

Drugs & Therapeutics for Cervicitis

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Drugs for Cervicitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
2
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
3
Azithromycin Approved Phase 4,Phase 3,Not Applicable 83905-01-5 55185 447043
4
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
5
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
6 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
7 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
8 Antimalarials Phase 4
9 Antiparasitic Agents Phase 4,Phase 2
10 Antibiotics, Antitubercular Phase 4
11 Antiprotozoal Agents Phase 4,Phase 2
12
Cefixime Approved, Investigational Phase 3,Not Applicable 79350-37-1 5362065 54362
13
Metronidazole Approved Phase 2 443-48-1 4173
14
Ceftriaxone Approved 73384-59-5 5479530 5361919

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
2 Periodical Presumptive Treatment for the Control of Gonococcal Infections Among Sex Workers Completed NCT01329588 Phase 4 Monthly antibiotic;Monthly placebo
3 Empiric Therapy of Mucopurulent Cervicitis (MPC) Terminated NCT01072136 Phase 3 Azithromycin;Cefixime
4 Metronidazole for Pulmonary Tuberculosis (South Korea) Completed NCT00425113 Phase 2 Metronidazole
5 "Performance of HPV DNA Test in Presence of Co-infection With Common RTIs" Unknown status NCT02830230 Not Applicable Tab cefixime,Tab Azithromycin
6 Chlamydia Trachomatis Immunology and Vaccinology Study Completed NCT01150747 ceftriaxone;Azithromycin
7 Maternal and Perinatal Outcome in Women With History of Premature Labor in Previous Pregnancy Completed NCT01375439 Not Applicable
8 The Role of Novel Organisms in Acute Endometritis Completed NCT01236131

Search NIH Clinical Center for Cervicitis

Cochrane evidence based reviews: uterine cervicitis

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Genetic Tests for Cervicitis

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Anatomical Context for Cervicitis

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MalaCards organs/tissues related to Cervicitis:

42
Cervix, Testes, T Cells, Colon, Neutrophil
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Publications for Cervicitis

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Articles related to Cervicitis:

(show top 50) (show all 372)
# Title Authors Year
1
Cervicitis: Etiology, diagnosis and treatment. ( 30630634 )
2019
2
Comparison of Chlorquinaldol-Promestriene Vaginal Tablets and Opin Suppositories Effect on Inflammatory Factors and Immune Function in Chronic HPV Cervicitis. ( 30700347 )
2019
3
Current status of Neisseria gonorrhoeae cervicitis in pregnant women in Japan. ( 30730922 )
2019
4
Chinese Herbal Formula Feilin Vaginal Gel Prevents the Cervicitis in Mouse Model. ( 30733810 )
2019
5
Why a Pelvic Exam is Needed to Diagnose Cervicitis and Pelvic Inflammatory Disease. ( 30902176 )
2019
6
Identifying acute cervicitis in an era of less-frequent routine gynecologic examinations. ( 29369931 )
2018
7
Ligneous cervicitis and endometritis: A gynaecological presentation of congenital plasminogen deficiency. ( 29436075 )
2018
8
An integrative investigation of the therapeutic mechanism of Ainsliaea fragrans Champ. in cervicitis using liquid chromatography tandem mass spectrometry based on a rat plasma metabolomics strategy. ( 29729635 )
2018
9
Comparative Metabolomics Analysis of Cervicitis in Human Patients and a Phenol Mucilage-Induced Rat Model Using Liquid Chromatography Tandem Mass Spectrometry. ( 29670527 )
2018
10
Efficacy and safety of combined high-dose interferon and red light therapy for the treatment of human papillomavirus and associated vaginitis and cervicitis: A prospective and randomized clinical study. ( 30213012 )
2018
11
The Additive Value of Pelvic Examinations to History in Predicting Sexually Transmitted Infections for Young Female Patients With Suspected Cervicitis or Pelvic Inflammatory Disease. ( 30251627 )
2018
12
A Clinical Conundrum: Chronic Cervicitis. ( 30582974 )
2018
13
Clinical efficacy of cryotherapy combined with interferon in the treatment of chronic cervicitis complicated with HPV infection. ( 29044006 )
2017
14
Effect of Dialyzable Leukocyte Extract on chronic cervicitis in patients with HPV infection. ( 29362599 )
2017
15
Chronic Cervicitis. ( 28232137 )
2017
16
Tuberculous cervicitis: A brief report with cytohistological correlation and differential diagnosis. ( 28891141 )
2017
17
Cystic Cervicitis: A Case Report and Literature Review of Cystic Cervical Lesions. ( 27331927 )
2016
18
Cervicitis: a prospective observational study of empiric azithromycin treatment in women with cervicitis and non-specific cervicitis. ( 26792283 )
2016
19
Histological Evidence of Chronic Mycoplasma genitalium-Induced Cervicitis in HIV-Infected Women: A Retrospective Cohort Study. ( 26783349 )
2016
20
Cervicitis aetiology and case definition: a study in Australian women attending sexually transmitted infection clinics. ( 26586777 )
2016
21
Chronic Cervicitis: Presenting Features and Response to Therapy. ( 27243142 )
2016
22
Cytopathological Examination and Epidemiological Study of Cervicitis in Commercial Sex Workers (CSWs) in Coal City (Enugu), Nigeria. ( 26633925 )
2015
23
Metabolomics analysis of cervical cancer, cervical intraepithelial neoplasia and chronic cervicitis by 1H NMR spectroscopy. ( 26050356 )
2015
24
Up-Regulation of miR-21 Is Associated with Cervicitis and Human Papillomavirus Infection in Cervical Tissues. ( 26010154 )
2015
25
Herpes Simplex Virus Cervicitis Mimicking Preterm Premature Rupture of Membranes. ( 25923023 )
2015
26
Relationship of Specific Bacteria in the Cervical and Vaginal Microbiotas With Cervicitis. ( 26267872 )
2015
27
Association between the human papillomavirus, bacterial vaginosis and cervicitis and the detection of abnormalities in cervical smears from teenage girls and young women. ( 26173042 )
2015
28
Prevalence of cervicitis in dairy cows and its effect on reproduction. ( 26483309 )
2015
29
Screening for Chlamydia and Gonorrhea Cervicitis and Implications for Pregnancy Outcome. Are We Testing and Treating at the Right Time? ( 26380488 )
2015
30
Cervicitis: How Often Is It Non-specific! ( 25954624 )
2015
31
Cervicitis of unknown etiology. ( 24859465 )
2014
32
Detection of human papillomavirus in chronic cervicitis, cervical adenocarcinoma, intraepithelial neoplasia and squamus cell carcinoma. ( 25147721 )
2014
33
High bacterial loads of Ureaplasma may be associated with non-specific cervicitis. ( 25017795 )
2014
34
Disseminated herpes simplex virus manifesting as pyrexia and cervicitis and leading to reactive hemophagocytic syndrome in pregnancy. ( 24890680 )
2014
35
Diagnosis of tuberculous cervicitis by Papanicolaou-stained smear. ( 22634489 )
2013
36
Ligneous cervicitis in a woman with plasminogen deficiency associated with an atypical form of microglandular hyperplasia: a case report and review of literature. ( 23518917 )
2013
37
Much is still unknown about cervicitis of unknown etiology. ( 23584805 )
2013
38
Accuracy and false-positive rate of the cytologic diagnosis of follicular cervicitis: observations from the College of American Pathologists Pap Educational Program. ( 23808462 )
2013
39
Prevalence and treatment outcome of cervicitis of unknown etiology. ( 23588127 )
2013
40
Torque teno mini virus infection in chronic cervicitis and cervical tumors in Isfahan, Iran. ( 23689906 )
2013
41
Human I^-defensin messenger RNA is overexpressed in the cervical epithelia of patients with nongonococcal cervicitis. ( 23774076 )
2013
42
Acute cervicitis and vulvovaginitis may be associated with Cytomegalovirus. ( 23606387 )
2013
43
Clinical and microscopic signs of cervicitis and urethritis: correlation with Chlamydia trachomatis infection in female STI patients. ( 23460336 )
2013
44
Human papillomavirus genotypes associated with mucopurulent cervicitis and cervical cancer in Hangzhou, China. ( 23886152 )
2013
45
Prevalence and predictors of cervicitis in female sex workers in Peru: an observational study. ( 23631602 )
2013
46
Cervicitis: limited clinical utility for the detection of Mycoplasma genitalium in a cross-sectional study of women attending a New Zealand sexual health clinic. ( 23702105 )
2013
47
Detection of human papillomavirus genotypes associated with mucopurulent cervicitis and cervical cancer in Changchun, China. ( 23245674 )
2013
48
Apparent Rarity of Asymptomatic Herpes Cervicitis in a Woman with Intra-Uterine Contraceptive Device. ( 28299103 )
2013
49
Urethritis/cervicitis pathogen prevalence and associated risk factors among asymptomatic HIV-infected patients in South Africa. ( 22706215 )
2012
50
Cervicitis associated with lateral cervical displacement. ( 22055917 )
2012
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Variations for Cervicitis

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Expression for Cervicitis

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Search GEO for disease gene expression data for Cervicitis.
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Pathways for Cervicitis

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Pathways related to Cervicitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Human T-cell leukemia virus 1 infection 38
11.77 CDKN2A IL2 IL2RA
2
Photodynamic therapy-induced AP-1 survival signaling. 1
11.08 CDKN2A IL2
3
Th2 Differentiation Pathway 66
10.98 IL2 IL2RA
4
G beta-gamma signalling through PI3Kgamma 67
Show member pathways
 10.98 GP6 IL2 IL2RA
5
Inflammatory Response Pathway 1
10.67 IL2 IL2RA
6
IL12 signaling mediated by STAT4 1
10.4 IL2 IL2RA
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GO Terms for Cervicitis

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Biological processes related to Cervicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interferon-gamma production GO:0032729 9.43 HSPD1 IL2
2 positive regulation of activated T cell proliferation GO:0042104 9.4 IL2 IL2RA
3 apoptotic mitochondrial changes GO:0008637 9.37 CDKN2A HSPD1
4 positive regulation of T cell differentiation GO:0045582 9.32 IL2 IL2RA
5 regulation of regulatory T cell differentiation GO:0045589 9.26 IL2 IL2RA
6 interleukin-2-mediated signaling pathway GO:0038110 9.16 IL2 IL2RA
7 negative regulation of lymphocyte proliferation GO:0050672 8.96 IL2 IL2RA
8 regulation of T cell homeostatic proliferation GO:0046013 8.62 IL2 IL2RA
Sources

Sources for Cervicitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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