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MCID: CRV039
MIFTS: 46

Cervicitis

Categories: Reproductive diseases
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Aliases & Classifications for Cervicitis

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MalaCards integrated aliases for Cervicitis:

Name: Cervicitis 11 53 14 75 33
Uterine Cervicitis 43 71
Inflammation of Cervix 33

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 31
ICD11: 33


External Ids:

Disease Ontology 11 DOID:2568
ICD9CM 34 616.0
MeSH 43 D002575
NCIt 49 C26716
SNOMED-CT 68 198199009 237081003
ICD10 31 N72
ICD11 33 1433247301
UMLS 71 C0007860 C0007861
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Summaries for Cervicitis

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Disease Ontology: 11 A cervix disease that is characterized by inflammation of the cervix.

MalaCards based summary: Cervicitis, also known as uterine cervicitis, is related to acute gonococcal cervicitis and acute cervicitis. An important gene associated with Cervicitis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Azithromycin and Lymecycline have been mentioned in the context of this disorder. Affiliated tissues include cervix, uterus and breast, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and immune system

Wikipedia: 75 Cervicitis is inflammation of the uterine cervix. Cervicitis in women has many features in common with... more...
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Related Diseases for Cervicitis

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Diseases in the Cervicitis family:

Acute Cervicitis Chronic Cervicitis

Diseases related to Cervicitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 825)
# Related Disease Score Top Affiliating Genes
1 acute gonococcal cervicitis 32.4 IL10 CXCL8
2 acute cervicitis 32.3 IL10 CXCL8 CD4
3 chronic cervicitis 32.2 ZNF582 SERPIND1 GP5 CDKN2A
4 pelvic inflammatory disease 31.1 TLR4 IL2 HSPD1
5 chlamydia 30.5 TNF TLR4 IL6 IL1B IL10 HSPD1
6 vulvovaginitis 30.4 IL10 HSPD1 CXCL8
7 syphilis 30.3 TNF CD8A CD4
8 endometritis 30.2 TNF TLR4 IL6 IL1B CXCL8
9 genital herpes 30.0 TNF TLR9 IL2 CD8A CD4
10 vaginal discharge 29.9 TNF IL6 IL1B IL10 CXCL8 CD4
11 bacterial vaginosis 29.9 TNF IL6 IL1B IL10 DEFB4A CXCL8
12 urethral syndrome 29.8 TNF IL6 CXCL8
13 vaginitis 29.7 TNF TLR4 IL6 IL1B IL10 HSPD1
14 measles 29.7 TLR9 TLR4 IL6 IL2RA IL2 IL1B
15 cystitis 29.6 TNF TLR4 IL6 IL2 CXCL8
16 cervix carcinoma 29.6 MIR21 GP5 CDKN2A CD8A CD4
17 conjunctivitis 29.5 TNF TLR4 IL6 IL2RA IL2 IL10
18 cervix uteri carcinoma in situ 29.5 ZNF582 SERPIND1 GP5 CDKN2A CD4
19 disseminated intravascular coagulation 29.4 TNF IL6 IL10
20 oral candidiasis 29.4 IL6 DEFB4A DEFB103B CD8A CD4
21 preterm premature rupture of the membranes 29.4 TNF TLR4 IL6 IL1B IL10 CXCL8
22 human papillomavirus infectious disease 29.4 MIR21 GP5 CDKN2A CD8A CD4
23 urethritis 29.4 TNF TLR4 IL6 IL1B IL10 HSPD1
24 salpingitis 29.3 TNF TLR4 IL6 IL1B IL10 HSPD1
25 chorioamnionitis 29.2 TNF TLR4 IL6 IL1B IL10 DEFB103B
26 trichomoniasis 29.2 TNF IL6 IL1B IL10 CXCL8 CD4
27 candidiasis 29.1 TNF TLR4 IL6 IL2 IL1B IL10
28 amebiasis 29.1 TNF TLR4 IL6 IL1B IL10 CXCL8
29 duodenal ulcer 29.0 TNF TLR4 IL6 IL1B IL10 CXCL8
30 erythema nodosum 29.0 TNF TLR9 IL6 IL1B IL10 CXCL8
31 peritonitis 29.0 TNF TLR4 IL6 IL1B IL10 CXCL8
32 anogenital venereal wart 29.0 TNF TLR9 TLR4 IL6 IL2 GP5
33 appendicitis 28.9 TNF TLR4 IL6 IL2 IL1B IL10
34 diarrhea 28.9 TNF TLR4 IL6 IL2 IL1B IL10
35 stomatitis 28.8 TNF IL6 IL2 IL1B IL10 CXCL8
36 urinary tract infection 28.8 TNF TLR4 IL6 IL1B IL10 CXCL8
37 tonsillitis 28.8 TNF TLR9 TLR4 IL6 IL2 IL1B
38 aphthous stomatitis 28.4 TNF IL6 IL2 IL1B IL10 CXCL8
39 exanthem 28.4 TNF IL6 IL2 IL1B IL10 CXCL8
40 viral infectious disease 28.2 TNF TLR9 TLR4 MIR21 IL6 IL2RA
41 cystic fibrosis 28.1 TNF TLR9 TLR4 IL6 IL2 IL1B
42 immune deficiency disease 27.9 TNF TLR9 MIR21 IL6 IL2RA IL2
43 behcet syndrome 27.7 TNF TLR9 TLR4 IL6 IL2RA IL2
44 chronic gonorrhea of cervix 11.4
45 endocervicitis 11.0
46 cervix disease 10.9
47 herpes simplex 10.4
48 cervical cancer 10.4
49 pilonidal sinus 10.4 IL2RA CD4
50 boutonneuse fever 10.3 TLR4 IL2 HSPD1

Graphical network of the top 20 diseases related to Cervicitis:



Diseases related to Cervicitis
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Symptoms & Phenotypes for Cervicitis

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GenomeRNAi Phenotypes related to Cervicitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.44 CDKN2A CXCL8 IL10 IL1B IL2RA TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.44 CDKN2A CXCL8 IL10 IL1B IL2 IL2RA

MGI Mouse Phenotypes related to Cervicitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.97 CD4 CD8A CDKN2A DEFB103B DEFB4A IL10
2 digestive/alimentary MP:0005381 9.91 CD4 CDKN2A IL10 IL2 IL2RA IL6
3 neoplasm MP:0002006 9.87 CDKN2A IL10 IL1B IL2 IL6 TLR4
4 respiratory system MP:0005388 9.56 CDKN2A HSPD1 IL10 IL2 IL2RA IL6
5 hematopoietic system MP:0005397 9.5 CD4 CD8A CDKN2A DEFB103B DEFB4A HSPD1
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Drugs & Therapeutics for Cervicitis

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Drugs for Cervicitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 447043
2
Lymecycline Approved, Investigational Phase 4 992-21-2
3
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
4
Tetracycline Approved, Vet_approved, Withdrawn Phase 4 60-54-8 5353990
5 Anti-Bacterial Agents Phase 4
6 Anti-Infective Agents Phase 4
7 Antibiotics, Antitubercular Phase 4
8 Antiprotozoal Agents Phase 4
9 Antiparasitic Agents Phase 4
10 Antimalarials Phase 4
11
Cefixime Approved, Investigational Phase 3 79350-37-1 5362065

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Antibiotic Treatment Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
2 A Randomized Trial to Evaluate the Need for Empiric Therapy for Mucopurulent Cervicitis of Unknown Etiology Terminated NCT01072136 Phase 3 Azithromycin;Cefixime
3 Histopathological Findings in Symptomatizing Patients After Supracervical Hysterectomy Completed NCT04809727
4 Maternal and Perinatal Outcome in Women With History of Premature Labor in Previous Pregnancy and Submitted to Active Search of Genital Infection Completed NCT01375439
5 Impact of a Rapid Test for Gonorrhea and Chlamydia on the Clinical Management of Urethritis and Cervicitis in a Sexual Health Clinic Not yet recruiting NCT05564299

Search NIH Clinical Center for Cervicitis

Cochrane evidence based reviews: uterine cervicitis

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Genetic Tests for Cervicitis

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Anatomical Context for Cervicitis

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Organs/tissues related to Cervicitis:

MalaCards : Cervix, Uterus, Breast, Neutrophil, T Cells, Skin, Testis
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Publications for Cervicitis

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Articles related to Cervicitis:

(show top 50) (show all 2082)
# Title Authors PMID Year
1
Human antibody responses to a Chlamydia-secreted protease factor. 53 62
15557641 2004
2
A Wriggly Problem of Cervix. 62
36457446 2022
3
Could HPV Type 33 Be More Risky Than We Thought? 62
36471500 2022
4
The prevalence of Mycoplasma hominis in Outpatients at a Tertiary Care Hospital in East India. 62
36382313 2022
5
Surgical outcomes of laparoscopic trachelectomy following supracervical hysterectomy: a multicenter study. 62
36254598 2022
6
Diagnostic value of colposcopy in patients with cytology-negative and HR-HPV-positive cervical lesions. 62
35320389 2022
7
Qualitative and Quantitative Detection of Multiple Sexually Transmitted Infection Pathogens Reveals Distinct Associations with Cervicitis and Vaginitis. 62
36314938 2022
8
Evaluation of 5-aminolevulinic acid-mediated photodynamic therapy in postmenopausal women with persistent HPV infection with or without cervical and vaginal low-grade squamous intraepithelial lesions (CIN1/VaIN1). 62
35830950 2022
9
A micro-Raman spectroscopy study of inflammatory condition of human cervix: Probing of tissues and blood plasma samples. 62
35661825 2022
10
Non-Invasive Differential Diagnosis of Cervical Neoplastic Lesions by the Lipid Profile Analysis of Cervical Scrapings. 62
36144287 2022
11
Establishment and application of a CRISPR-Cas12a-based RPA-LFS and fluorescence for the detection of Trichomonas vaginalis. 62
36180879 2022
12
ThinPrep cytologic test combined with HPV typing to evaluate the degree of cervical diseases and the relationship between HPV typing and the pathological results of patients with atypical squamous cells of undetermined significance: a diagnostic test. 62
36237241 2022
13
Associations between ubiquitin, follicle-stimulating hormone, and sex steroid hormones in the failed to conceive female dromedary camels raised in hot climates. 62
36313844 2022
14
Expression of Hormones, Cytokines, and Antioxidants in Heat-Stressed Subfertile Female Dromedaries. 62
36009715 2022
15
Disseminated Gonococcal Infection: An Unusual Presentation Resembling a Lupus Flare. 62
36176869 2022
16
ROC-Analysis Derived Immunohistochemical P53 Cut-Off Scores as an Adjunct to Routine Histopathology for Better Diagnostic Compartmentalisation of Cervical Lesions. 62
36131854 2022
17
Antibacterial and anti-trichomunas characteristics of local landraces of Lawsonia inermis L. 62
35907942 2022
18
Papillary thyroid cancer with suspicious uterine cervix metastasis: a case report and literature review. 62
35935566 2022
19
Methylated ZNF582 as a triage marker for occult cervical cancer and advanced cervical intraepithelial neoplasia. 62
35758002 2022
20
The association between common urogenital infections and cervical neoplasia - A nationwide cohort study of over four million women (2002-2018). 62
35494213 2022
21
The clinical indications for testing women for Mycoplasma genitalium. 62
34210839 2022
22
Mycoplasma genitalium and Chlamydia trachomatis infection among women in Southwest China: a retrospective study. 62
35734919 2022
23
Histomorphological Evaluation of Non-Neoplastic Lesions of Uterine Cervix and a Correlation of the Lesion with the Clinical Factors. 62
35658885 2022
24
Immune and microbiological disorders in women with infectious and inflammatory pathology of the cervix. 62
35613351 2022
25
Diagnostic value of the QuickStripeâ„¢ chlamydia rapid test among high-risk women in Jakarta. 62
35341395 2022
26
2021 European guideline on the management of Mycoplasma genitalium infections. 62
35182080 2022
27
Cervical Power Doppler Angiography with Micro Vessel Blood Flow Indices in the Auxiliary Diagnosis of Acute Cervicitis. 62
35626287 2022
28
Shotgun Lipidomics for Differential Diagnosis of HPV-Associated Cervix Transformation. 62
35736434 2022
29
Could combination of radical hysterectomy and radiation effective in the treatment of primary cervical signet ring cell carcinoma?: A rare case report. 62
35430518 2022
30
Detection of Neisseria gonorrhoeae or Chlamydia trachomatis from oral wash specimens using the Abbott RealTime CT/NG assay and the Cobas 4800 CT/NG assay: A prospective study. 62
34930626 2022
31
[Necrotic cervicitis for co-infection of herpes simplex virus 2 and Mycoplasma genitalium]. 62
35856996 2022
32
Clinical Importance of Superior Sensitivity of the Aptima TMA-Based Assays for Mycoplasma genitalium Detection. 62
35317613 2022
33
Retrospective Analysis of Ugandan Men with Urethritis Reveals Mycoplasma genitalium and Associated Macrolide Resistance. 62
35412392 2022
34
Loop Electrosurgical Excision Procedure under Propofol Intravenous Anesthesia Combined with Nano-Silver Gel in the Treatment of Cervicitis. 62
35988193 2022
35
Arginase is involved in cervical lesions progression and severity. 62
35220072 2022
36
Histopathological profile of cervical biopsies in northern Malawi: a retrospective cross-sectional study. 62
35277397 2022
37
Lower accuracy of cytological screening for high-grade squamous intraepithelial neoplasia in women over 50 years of age in Japan. 62
34873649 2022
38
Mycoplasma genitalium and sexually transmitted infections: evidences and figures in a tertiary hospital. 62
34915694 2022
39
[Sexually Transmitted Infections During the First Wave of the COVID-19 Pandemic in Spain]. 62
34538874 2022
40
Histopathological profile of cervical punch biopsies and risk factors associated with high-grade cervical precancerous lesions and cancer in northwest Ethiopia. 62
36094938 2022
41
Chronic Cervicitis and Cervical Cancer Detection Based on Deep Learning of Colposcopy Images Toward Translational Pharmacology. 62
35712722 2022
42
Diagnostic Value and Clinical Application of Diffusion-Weighted Magnetic Resonance Imaging for Female Pelvic Lesions. 62
35833078 2022
43
Effect of Mirena placement on reproductive hormone levels at different time intervals after artificial abortion. 62
35097076 2022
44
Efficacy of Acacia nilotica Linn. Pod's Sitz Bath plus Vaginal Pessary in Syndromic Management of Abnormal Vaginal Discharge: A Randomized Controlled Trial. 62
35664940 2022
45
Mycoplasma genitalium: A new superbug. 62
35846530 2022
46
Analysis of Serum Levels of IFN-γ, IL-4, and TNF-α in Patients with Cervicitis Complicated by HPV Infection and Their Clinical Significance. 62
35463689 2022
47
Characterization of allergic inflammation in chronic uterine cervicitis. 62
35020843 2022
48
Primary and Triage Cervical Screening Diagnostic Value of Methods for the Detection of Cervical Dysplasia. 62
36164451 2022
49
Expanded Histopathology and Tropism of Ebola Virus in the Rhesus Macaque Model: Potential for Sexual Transmission, Altered Adrenomedullary Hormone Production, and Early Viral Replication in Liver. 62
34626576 2022
50
The Pap smear in inflammation and repair. 62
35673696 2022
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Variations for Cervicitis

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Expression for Cervicitis

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Search GEO for disease gene expression data for Cervicitis.
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Pathways for Cervicitis

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Pathways related to Cervicitis according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14.05 TNF TLR9 TLR4 IL6 IL2RA IL2
2
ERK Signaling 64
Show member pathways
 13.86 TNF IL6 IL2RA IL2 IL1B IL10
3
MIF Mediated Glucocorticoid Regulation 64
Show member pathways
 13.68 TNF TLR4 IL6 IL2RA IL2 IL1B
4
TGF-Beta Pathway 64
Show member pathways
 13.58 TNF IL6 IL2RA IL2 IL1B IL10
5
Prolactin Signaling 64
Show member pathways
 13.53 TNF TLR9 TLR4 IL6 IL2RA IL2
6
Akt Signaling 64
Show member pathways
 13.5 TNF TLR9 TLR4 IL6 IL2RA IL2
7
Cytokine Signaling in Immune system 66
Show member pathways
 13.39 TNF IL6 IL2RA IL2 IL1B IL10
8
PAK Pathway 64
Show member pathways
 13.37 TNF IL6 IL2RA IL2 IL1B IL10
9
Toll-like receptor signaling pathway 74
Show member pathways
 12.95 TNF TLR9 TLR4 IL6 IL2RA IL2
10
NF-KappaB Family Pathway 64
Show member pathways
 12.8 IL1B IL2 IL6 TLR4 TLR9 TNF
11
Overview of interferons-mediated signaling pathway 74
Show member pathways
 12.73 CXCL8 IL10 IL1B IL2 IL2RA IL6
12
Immune response IL-23 signaling pathway 22
Show member pathways
 12.69 TNF IL6 IL2 IL1B IL10 CD4
13
IL-1 Family Signaling Pathways 65
Show member pathways
 12.68 TNF TLR9 IL6 IL1B CXCL8
14
NF-kappaB Signaling 3
12.68 CD8A IL10 IL1B IL2 IL2RA TLR9
15
Toll-Like receptor Signaling Pathways 65
Show member pathways
 12.64 TNF TLR9 TLR4 IL6 IL1B CXCL8
16
Bacterial infections in CF airways 22
Show member pathways
 12.47 TNF TLR9 TLR4 IL6 IL1B DEFB4A
17
Toll Comparative Pathway 64
Show member pathways
 12.4 CXCL8 IL1B IL6 TLR4 TNF
18
Sudden infant death syndrome (SIDS) susceptibility pathways 74
12.26 TNF IL6 IL1B IL10 HSPD1 CXCL8
19
Colorectal Cancer Metastasis 64
12.25 IL6 TLR4 TLR9 TNF
20
T-cell activation SARS-CoV-2 74
Show member pathways
 12.23 TNF IL2 IL10 CDKN2A CD8A CD4
21
Neuroinflammation and glutamatergic signaling 74
12.17 IL10 IL1B IL6 TNF
22
MAPK Pathway 70
Show member pathways
 12.15 TLR9 TLR4 IL2RA IL2 IL1B
23
IL12-mediated signaling events 61
Show member pathways
 12.11 IL2RA IL2 IL1B CD8A CD4
24
Interleukin-4 and Interleukin-13 signaling 66
12.09 TNF IL6 IL1B IL10 CXCL8
25
Senescence and autophagy in cancer 74
12.03 IL6 IL1B CXCL8 CDKN2A
26
Spinal cord injury 74
12.03 TNF TLR4 IL6 IL2 IL1B CXCL8
27
Th17 Differentiation 65
Show member pathways
 12 TLR9 TLR4 IL6 IL1B CD4
28
Burn wound healing 74
11.91 TNF TLR4 IL6 IL1B CXCL8
29
Acute viral myocarditis 74
11.9 TLR4 IL6 IL2 IL10 CD4
30
Allograft rejection 74
11.9 TNF IL2RA IL2 IL1B IL10 CXCL8
31
Network map of SARS-CoV-2 signaling pathway 74
Show member pathways
 11.88 IL6 CXCL8 CD8A CD4
32
Extrafollicular B cell activation by SARS-CoV-2 74
11.85 TNF TLR4 IL6 IL2 IL10
33
AP-1 transcription factor network 61
11.84 CDKN2A CXCL8 IL10 IL2 IL6
34
Th17 cell differentiation pathway 74
11.83 CD4 IL1B IL2 IL2RA IL6
35
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 61
Show member pathways
 11.82 TNF IL2RA IL2 CXCL8
36
Hematopoietic Stem Cells and Lineage-specific Markers 65
11.82 CD4 CD8A GP5 IL10 IL2 IL2RA
37
Glucocorticoid receptor regulatory network 61
11.81 IL6 IL2 CXCL8
38
Lung fibrosis 74
11.79 TNF IL6 IL1B CXCL8
39
Innate Lymphoid Cells Differentiation 65
11.77 TNF IL2RA IL2 IL1B IL10 CD8A
40
Photodynamic therapy-induced NF-kB survival signaling 74
Show member pathways
 11.76 TNF IL6 IL2 IL1B CXCL8
41
IL 10 signaling pathway 67
11.75 IL10 IL1B IL6 TLR4 TNF
42
Inflammatory bowel disease signaling 74
Show member pathways
 11.72 TNF TLR4 IL6 IL2 IL10
43
THC Differentiation Pathway 64
11.68 TNF IL2RA IL2 IL10 CD4
44
NF-kB (NFkB) Pathway 67
11.66 CD4 TLR4 TNF
45
SHP2 signaling 61
11.65 IL6 IL2RA IL2
46
Th2 Differentiation 65
11.64 CD4 IL10 IL2 IL2RA
47
Non-genomic actions of 1,25 dihydroxyvitamin D3 74
11.64 TNF TLR4 IL6 DEFB4A CXCL8
48
miRNAs involvement in the immune response in sepsis 74
11.64 TNF TLR4 MIR21 IL6 IL10 CXCL8
49
SARS-CoV-2 innate immunity evasion and cell-specific immune response 74
11.62 TNF IL10 CXCL8
50
MSP-RON Signaling 64
11.59 TNF TLR4 IL1B
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GO Terms for Cervicitis

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Cellular components related to Cervicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.68 TNF SERPIND1 MIR21 IL6 IL2 IL1B
2 lipopolysaccharide receptor complex GO:0046696 9.26 TLR4 HSPD1

Biological processes related to Cervicitis according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 10.41 TNF TLR9 TLR4 IL6 IL2RA IL1B
2 negative regulation of cell population proliferation GO:0008285 10.38 CDKN2A CXCL8 IL10 IL1B IL6 MIR21
3 positive regulation of gene expression GO:0010628 10.37 CDKN2A CXCL8 IL1B IL6 MIR21 TLR4
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.36 TNF TLR9 TLR4 IL1B CD4
5 defense response to bacterium GO:0042742 10.32 DEFB103B DEFB4A IL10 TLR4 TLR9 TNF
6 positive regulation of DNA-binding transcription factor activity GO:0051091 10.31 TNF IL6 IL1B IL10
7 positive regulation of protein phosphorylation GO:0001934 10.3 TNF MIR21 IL2 IL1B CD4
8 positive regulation of JNK cascade GO:0046330 10.29 IL1B TLR4 TLR9 TNF
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.29 TNF TLR9 TLR4 IL6 IL1B
10 defense response to Gram-positive bacterium GO:0050830 10.27 TNF IL6 IL1B DEFB4A DEFB103B
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 10.24 IL1B TLR4 TLR9 TNF
12 negative regulation of interleukin-6 production GO:0032715 10.22 IL10 TLR4 TLR9 TNF
13 positive regulation of interleukin-12 production GO:0032735 10.2 TLR9 TLR4 HSPD1
14 positive regulation of nitric oxide biosynthetic process GO:0045429 10.19 TNF TLR4 IL1B
15 immune system process GO:0002376 10.19 CD4 CD8A IL2 IL2RA TLR4 TLR9
16 lipopolysaccharide-mediated signaling pathway GO:0031663 10.19 TNF TLR4 IL1B
17 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.18 IL10 IL6 TNF
18 liver regeneration GO:0097421 10.18 TNF IL6 IL10
19 I-kappaB kinase/NF-kappaB signaling GO:0007249 10.17 IL1B TLR4 TLR9 TNF
20 negative regulation of neurogenesis GO:0050768 10.15 TNF IL6 IL1B
21 positive regulation of interferon-alpha production GO:0032727 10.15 TLR9 TLR4 HSPD1
22 positive regulation of interleukin-10 production GO:0032733 10.15 TLR9 TLR4 IL6 HSPD1
23 positive regulation of inflammatory response GO:0050729 10.14 TNF TLR9 TLR4 MIR21 IL2 IL1B
24 MyD88-dependent toll-like receptor signaling pathway GO:0002755 10.13 TLR9 TLR4 HSPD1
25 positive regulation of macrophage activation GO:0043032 10.13 TLR4 IL10 HSPD1
26 positive regulation of interleukin-8 production GO:0032757 10.13 TNF TLR9 TLR4 IL6 IL1B
27 positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 10.12 TNF MIR21 IL10
28 positive regulation of glial cell proliferation GO:0060252 10.12 TNF IL6 IL1B
29 positive regulation of T cell proliferation GO:0042102 10.11 IL6 IL2RA IL2 IL1B
30 positive regulation of immunoglobulin production GO:0002639 10.1 TLR9 IL6 IL2 IL10
31 positive regulation of interleukin-6 production GO:0032755 10.1 TNF TLR9 TLR4 IL6 IL1B HSPD1
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 10.09 TNF IL1B IL10
33 positive regulation of activated T cell proliferation GO:0042104 10.08 MIR21 IL2RA IL2
34 negative regulation of mitotic cell cycle GO:0045930 10.07 IL10 MIR21 TNF
35 response to molecule of bacterial origin GO:0002237 10.04 TLR9 IL10 CXCL8
36 positive regulation of neuroinflammatory response GO:0150078 10.03 IL1B IL6 TNF
37 defense response to Gram-negative bacterium GO:0050829 10.03 CD4 DEFB103B DEFB4A IL6 TLR4 TLR9
38 negative regulation of cytokine production involved in immune response GO:0002719 10.02 TNF IL10
39 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.02 TNF TLR4 MIR21 IL6
40 positive regulation of chemokine production GO:0032722 10.02 IL1B IL6 TLR4 TLR9 TNF
41 positive regulation of fever generation GO:0031622 10.01 TNF IL1B
42 defense response GO:0006952 10.01 TNF DEFB4A DEFB103B CXCL8
43 sequestering of triglyceride GO:0030730 10 TNF IL1B
44 positive regulation of cytokine production GO:0001819 10 IL10 IL1B MIR21 TLR9 TNF
45 positive regulation of plasma cell differentiation GO:1900100 9.99 IL2 IL10
46 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.99 TNF IL1B
47 regulation of T cell homeostatic proliferation GO:0046013 9.99 IL2RA IL2
48 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.99 TNF MIR21 IL6
49 vascular endothelial growth factor production GO:0010573 9.99 TNF IL6 IL1B
50 regulation of dendritic cell cytokine production GO:0002730 9.98 TLR9 TLR4

Molecular functions related to Cervicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.36 TNF IL6 IL2 IL1B IL10 CXCL8
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Sources for Cervicitis

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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