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MCID: CRV039
MIFTS: 49

Cervicitis

Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cervicitis

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MalaCards integrated aliases for Cervicitis:

Name: Cervicitis 12 54 15
Uterine Cervicitis 43 71

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:2568
ICD9CM 34 616.0
MeSH 43 D002575
NCIt 49 C26716
SNOMED-CT 67 198199009 37610005
ICD10 32 N72
UMLS 71 C0007860 C0007861
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Summaries for Cervicitis

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Disease Ontology : 12 A cervix disease that is characterized by inflammation of the cervix.

MalaCards based summary : Cervicitis, also known as uterine cervicitis, is related to cervical adenosarcoma and chronic cervicitis. An important gene associated with Cervicitis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Tetracycline and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include cervix, testes and t cells, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 74 Cervicitis is inflammation of the uterine cervix. Cervicitis in women has many features in common with... more...

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Related Diseases for Cervicitis

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Diseases in the Cervicitis family:

Acute Cervicitis Chronic Cervicitis

Diseases related to Cervicitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 3000)
# Related Disease Score Top Affiliating Genes
1 cervical adenosarcoma 34.2 GP6 GP5
2 chronic cervicitis 33.7 SERPIND1 GP6 GP5 CDKN2A
3 acute cervicitis 33.4 MT-TG IL1B
4 cervical adenitis 33.3 IL1B HSPD1 CD4
5 cervix uteri carcinoma in situ 32.8 SERPIND1 GP6 GP5 CDKN2A
6 spinal cord injury 31.4 TNF IL6 CXCL8
7 cervical cancer 31.3 TNF TLR9 TLR4 MIR21 IL6 IL2
8 kawasaki disease 31.1 TNF IL6 IL2 IL1B HSPD1 CD4
9 vaginal cancer 30.7 GP5 CDKN2A CD4
10 spinal cord disease 30.6 TNF IL6 IL2 IL1B CD8A CD4
11 fasciitis 30.5 TNF IL6 IL2 CXCL8
12 myelitis 30.5 TNF IL6 CXCL8
13 allergic hypersensitivity disease 30.4 TNF IL2 CXCL8 CD4
14 oropharynx cancer 30.4 GP6 GP5 CDKN2A
15 mycobacterium fortuitum 30.3 HSPD1 CXCL8
16 toxoplasmosis 30.3 TNF TLR9 TLR4 TLR2 IL6 IL1B
17 thyroiditis 30.3 TNF IL6 IL2
18 necrotizing fasciitis 30.1 IL6 IL2 IL1B CXCL8
19 genital herpes 30.1 TLR2 CD8A CD4
20 bell's palsy 30.1 IL2RA CD8A CD4
21 pilonidal sinus 30.1 IL2RA CD4
22 cystitis 30.1 TNF TLR4 IL6 IL2 CXCL8
23 transverse myelitis 30.1 TNF IL6 CXCL8
24 coccidioidomycosis 30.0 TNF TLR4 CD4
25 acute transverse myelitis 29.9 IL6 CXCL8
26 pelvic inflammatory disease 29.9 TLR4 TLR2 NAT9 IL2 HSPD1 CD4
27 lymphadenitis 29.9 TNF TLR4 IL2RA IL1B CXCL8 CD4
28 syphilis 29.9 TNF IL6 CD8A CD4
29 chronic graft versus host disease 29.9 IL2RA CD4
30 vulvovaginal candidiasis 29.8 TLR2 IL2 DEFB4A
31 cerebrovascular disease 29.8 TNF TLR4 MIR21 IL6
32 poliomyelitis 29.8 TNF CD8A CD4
33 anus cancer 29.8 GP6 GP5 CDKN2A CD8A CD4
34 adult t-cell leukemia 29.8 IL2RA IL2 CDKN2A CD4
35 arteriosclerosis 29.8 TLR4 MIR21 IL6 HSPD1
36 herpes simplex 29.8 TNF TLR9 TLR2 IL6 CD8A
37 brucellosis 29.8 TNF TLR4 IL6 IL2 CXCL8
38 arteriovenous malformation 29.8 TNF IL6 IL1B
39 carpal tunnel syndrome 29.7 IL6 IL2 IL1B
40 nasopharyngeal carcinoma 29.7 TNF MIR21 IL6 CXCL8 CDKN2A
41 conjunctivitis 29.7 TNF IL6 IL2 CXCL8
42 histoplasmosis 29.7 TNF CD8A CD4
43 mycobacterium kansasii 29.7 TLR2 CXCL8
44 intestinal obstruction 29.7 TNF IL6 CD8A
45 neurosarcoidosis 29.7 TNF CD8A CD4
46 portal hypertension 29.7 TNF TLR4 CXCL8 CD4
47 esophageal cancer 29.6 TNF TLR4 MIR21 IL6 IL2 IL1B
48 vaginal discharge 29.6 TNF IL6 IL1B CXCL8 CD4
49 thymoma 29.6 TNF IL6 IL2 CDKN2A CD8A
50 lymphoblastic lymphoma 29.6 CDKN2A CD8A CD4

Graphical network of the top 20 diseases related to Cervicitis:



Diseases related to Cervicitis
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Symptoms & Phenotypes for Cervicitis

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MGI Mouse Phenotypes related to Cervicitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.25 CD4 CD8A CDKN2A GP6 HSPD1 IL1B
2 homeostasis/metabolism MP:0005376 10.18 CD4 CDKN2A GP5 GP6 IL1B IL2
3 cardiovascular system MP:0005385 10.16 CDKN2A HSPD1 IL1B IL2 IL2RA IL6
4 immune system MP:0005387 10.1 CD4 CD8A CDKN2A GP6 IL1B IL2
5 digestive/alimentary MP:0005381 10.09 CD4 CDKN2A IL2 IL2RA IL6 TLR2
6 mortality/aging MP:0010768 10 CD4 CD8A CDKN2A GP6 HSPD1 IL1B
7 integument MP:0010771 9.91 CD4 CD8A CDKN2A GP6 IL1B IL6
8 neoplasm MP:0002006 9.5 CDKN2A IL1B IL2 IL6 TLR2 TLR4
9 respiratory system MP:0005388 9.23 CDKN2A HSPD1 IL2 IL2RA IL6 TLR2
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Drugs & Therapeutics for Cervicitis

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Drugs for Cervicitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
2
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
3
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
4
Azithromycin Approved Phase 4 83905-01-5 447043 55185
5
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
6
Levonorgestrel Approved, Investigational Phase 4 797-63-7, 17489-40-6 13109
7 Antimalarials Phase 4
8 Anti-Bacterial Agents Phase 4
9 Anti-Infective Agents Phase 4
10 Antibiotics, Antitubercular Phase 4
11 Contraceptives, Oral Phase 4
12 Contraceptive Agents Phase 4
13
Cefixime Approved, Investigational Phase 3 79350-37-1 5362065 54362
14
acetic acid Approved Phase 3 64-19-7 176
15 Vaccines Phase 3
16 Pharmaceutical Solutions Phase 3
17
Retinol acetate Phase 3 127-47-9 10245972
18
Metronidazole Approved Phase 2 443-48-1 4173
19 Antiparasitic Agents Phase 2
20 Antiprotozoal Agents Phase 2
21
Ceftriaxone Approved 73384-59-5 5361919 5479530
22
Copper Approved, Investigational 7440-50-8 27099
23
Progesterone Approved, Vet_approved 57-83-0 5994
24 Copper Supplement
25 Anesthetics
26 Hormones
27 Hormone Antagonists
28 Progestins

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Study of Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Antibiotic Treatment Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
2 Periodical Presumptive Treatment of Gonorrhoea in Female Sex Workers: Impact on Prevalence of the Disease in Sex Workers and Their Clients Completed NCT01329588 Phase 4 Monthly antibiotic;Monthly placebo
3 Immediate Versus Delayed Insertion of the Levonorgestrel-Releasing Intrauterine Device Following Dilation and Evacuation: A Randomized Controlled Trial Completed NCT00475228 Phase 4 Levonorgestrel IUD
4 A Multi-centre Randomised Controlled Trial Evaluating the Efficacy of the Four-component Meningococcal B Vaccine, 4CMenB (Bexsero®), in the Prevention of Neisseria Gonorrhoeae Infection in Gay and Bisexual Men Not yet recruiting NCT04415424 Phase 3
5 A Randomized Trial to Evaluate the Need for Empiric Therapy for Mucopurulent Cervicitis of Unknown Etiology Terminated NCT01072136 Phase 3 Azithromycin;Cefixime
6 Safety and Efficacy of Two Screen-and-Treat Approaches for the Prevention of Cervical Cancer Terminated NCT00233727 Phase 3
7 A Randomized, Double-Blind, Placebo-Controlled Phase II Study of Metronidazole Combined With Antituberculous Chemotherapy vs. Antituberculous Chemotherapy With Placebo in Subjects With Multi-Drug Resistant Pulmonary Tuberculosis Completed NCT00425113 Phase 2 Metronidazole
8 "Performance of HPV DNA Test in Presence of Co-infection With Common RTIs" Unknown status NCT02830230 Tab cefixime,Tab Azithromycin
9 Efficacy Study of Rapid Immunoassay Diagnostic Test Utilizing PP12 and AFP, ROM Plus Unknown status NCT02524691
10 Maternal and Perinatal Outcome in Women With History of Premature Labor in Previous Pregnancy and Submitted to Active Search of Genital Infection Completed NCT01375439
11 Chlamydia Trachomatis Immunology and Vaccinology Study: Determination of Protective T Cell Responses to Chlamydia Trachomatis Infection Completed NCT01150747 ceftriaxone;Azithromycin
12 The Effect of the Levonorgestrel-Releasing Intrauterine System and the Copper-Intrauterine Device (TCu 380A) on Subendometrial Microvascularization and Uterine Artery Blood Flow. Completed NCT00489463
13 Clinical Description of Spondylarthritis and Validation of Assessment of SpondyloArthritis International Society (ASAS) Criteria in West Indian Patients Seen in the Routine Consultation of Rheumatology. Recruiting NCT03564743
14 A Randomized Controlled Trial Comparing Cure Rates of Cervical Intraepithelial Neoplasia Grade 2 and Higher (CIN2+) Treated With CO2-based Cryotherapy, CropPen, and Thermoablation (UH3) Recruiting NCT03084081
15 The Effectiveness of Cervical Pessary Compared to Cervical Cerclage With or Without Vaginal Progesterone for the Prevention of Preterm Birth in Women With a Twin Pregnancy and a Short Cervix: a Two-by-two Factorial Randomised Clinical Trial Recruiting NCT03863613 Vaginal progesterone
16 Comparison of Cervical Intraepithelial Neoplasia 2/3 Treatment Outcomes With a Portable LMIC-adapted Thermal Ablation Device vs. Gas-based Cryotherapy Not yet recruiting NCT03429582

Search NIH Clinical Center for Cervicitis

Cochrane evidence based reviews: uterine cervicitis

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Genetic Tests for Cervicitis

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Anatomical Context for Cervicitis

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MalaCards organs/tissues related to Cervicitis:

40
Cervix, Testes, T Cells, Colon, Breast, Skin, Neutrophil
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Publications for Cervicitis

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Articles related to Cervicitis:

(show top 50) (show all 1928)
# Title Authors PMID Year
1
Human antibody responses to a Chlamydia-secreted protease factor. 61 54
15557641 2004
2
Associations between the expression of SCCA, MTA1, P16, Ki-67 and the infection of high-risk HPV in cervical lesions. 61
32566016 2020
3
The application value of PAX1 and ZNF582 gene methylation in high grade intraepithelial lesion and cervical cancer. 61
32514824 2020
4
Structure and mechanism of the Nap adhesion complex from the human pathogen Mycoplasma genitalium. 61
32513917 2020
5
Brucellar reproductive system injury: A retrospective study of 22 cases and review of the literature. 61
32552113 2020
6
Meningococcal disease and sexual transmission: urogenital and anorectal infections and invasive disease due to Neisseria meningitidis. 61
32534649 2020
7
The frontiers of addressing antibiotic resistance in Neisseria gonorrhoeae. 61
32119845 2020
8
Reconsidering Presumptive Neisseria gonorrhoeae Treatment For Women With Cervicitis. 61
32149957 2020
9
Cervicitis: Balancing the Goals of Empiric Therapy and Antimicrobial Stewardship to Improve Women's Health. 61
32421298 2020
10
Impact of cervicitis on performance of cervical cancer screening using HRHPV testing and visual evaluation in women living with HIV in Botswana. 61
32449207 2020
11
Relevance research between the expression of p16INK4a , Notch1, and hTERC genes: The development of HPV16-positive cervical cancer. 61
31976596 2020
12
The Role of CADM1 and MAL Promoter Methylation in Inflammation and Cervical Intraepithelial Neoplasia. 61
32311274 2020
13
Formulation, Physiochemical, and Microbial Assay of Henna Oil Vaginal Suppository Formulated with Polyethylene Glycol Bases. 61
32546887 2020
14
The Chinese herbal prescription JZ-1 induces autophagy to protect against herpes simplex Virus-2 in human vaginal epithelial cells by inhibiting the PI3K/Akt/mTOR pathway. 61
32088246 2020
15
p16/Ki-67 dual-stained cytology used for triage in cervical cancer opportunistic screening. 61
32410798 2020
16
A profile of the cobas® TV/ MG test for the detection of Trichomonas vaginalis and Mycoplasma genitalium. 61
31917618 2020
17
Characteristics of Mycoplasma genitalium urogenital infections in a diverse patient sample from the United States; results from the Aptima Mycoplasma genitalium Evaluation Study (AMES). 61
32321783 2020
18
Uterine cervix as a fundamental part of the pathogenesis of pregnancy loss associated with ascending placentitis in mares. 61
31732164 2020
19
A case of Mycoplasma genitalium possible resistance in a woman. 61
32258345 2020
20
Positive staining of the immunoligand B7-H6 in abnormal/transformed keratinocytes consistently accompanies the progression of cervical cancer. 61
32138659 2020
21
Description of Referrals for Colposcopy in a Hospital in Brazil. 61
32232821 2020
22
Mycoplasma genitalium, a stealth female reproductive tract. 61
31522281 2020
23
Mycoplasma genitalium prevalence in Welsh sexual health patients: Low antimicrobial resistance markers and no association of symptoms to bacterial load. 61
31756372 2020
24
Rationale for a Neisseria gonorrhoeae Susceptible-only Interpretive Breakpoint for Azithromycin. 61
30963175 2020
25
Prevalence and incidence of Mycoplasma genitalium in a cohort of HIV-infected and HIV-uninfected pregnant women in Cape Town, South Africa. 61
31932358 2020
26
Mycoplasma genitalium: A Review. 61
31329090 2020
27
A Sensitive and Simplified Classifier of Cervical Lesions Based on a Methylation-Specific PCR Assay: A Chinese Cohort Study. 61
32346310 2020
28
Reliability of conventional Papanicolaou smear in diagnosing bacterial vaginosis among women with clinical genital infection. 61
31956611 2020
29
[The value of P16/ki67 double labeling, HPV E6/E7 mRNA detection and their combined application in cytological shunt diagnosis of low-grade squamous intraepithelial lesions]. 61
32314725 2020
30
Characterization of DNA hydroxymethylation profile in cervical cancer. 61
31271297 2019
31
Downregulation of Mad2 and BubR1 increase the malignant potential and nocodazole resistance by compromising spindle assembly checkpoint signaling pathway in cervical carcinogenesis. 61
31523901 2019
32
Cervicitis: Etiology, diagnosis and treatment. 61
30630634 2019
33
Evaluation of the prevalence of sexually transmitted bacterial pathogens in Northern Cyprus by nucleic acid amplification tests, and investigation of the relationship between these pathogens and cervicitis. 61
32231855 2019
34
National Institute of Allergy and Infectious Diseases workshop report: "Chlamydia vaccines: The way forward". 61
29097007 2019
35
Comparison of the AV Magnivisualizer device with colposcopy to detect cervical intraepithelial neoplasia using the Swede scoring system. 61
31353466 2019
36
Gonorrhoea. 61
31754194 2019
37
Human papillomavirus type 18/16 infection and prevalence among middle-aged and older Chinese rural women: a cross-sectional survey in Wufeng, Hubei Province. 61
30917772 2019
38
Infections caused by Chlamydia trachomatis (including lymphogranuloma venereum) and Mycoplasma genitalium. 61
30878312 2019
39
An update on prevalence, diagnosis, treatment and emerging issues of genital mycoplasma infection in Indian women: A narrative review. 61
31389367 2019
40
[Study on Dynamic Changes of Human Papillomavirus 16 E5 Gene in the Occurrence of Cervical Cancer]. 61
31762235 2019
41
Characteristics of carcinogenic HPV genotypes in North China Plain and the association with cervical lesions. 61
31517830 2019
42
Urogenital chlamydia trachomatis treatment failure with azithromycin: A meta-analysis. 61
31646255 2019
43
Sexually Transmitted Infections: Prevention, Diagnosis, and Treatment in Primary Care. 61
31505011 2019
44
Correlation between cervical carcinogenesis and tobacco use by sexual partners. 61
31802062 2019
45
Ki-67 and P16 proteins in cervical cancer and precancerous lesions of young women and the diagnostic value for cervical cancer and precancerous lesions. 61
31423197 2019
46
Syphilitic Cervicitis with Cervical Cancer Presenting as Oropharyngeal Syphilis. 61
30996173 2019
47
Emerging role for Ureaplasma parvum serovar 3: Active infection in women with silent high-risk human papillomavirus and in women with idiopathic infertility. 61
30883747 2019
48
Predominance of cervicitis agents with minimal testing rate within the student population in Benin city, Nigeria. 61
31007108 2019
49
[Detection and analysis of FAM19A4 promoter methylation in cervical exfoliated cells]. 61
31269601 2019
50
Mycoplasma genitalium Infections in Women Attending a Sexually Transmitted Disease Clinic in New Orleans. 61
30351348 2019
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Variations for Cervicitis

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Expression for Cervicitis

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Search GEO for disease gene expression data for Cervicitis.
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Pathways for Cervicitis

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Pathways related to Cervicitis according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.1 TNF TLR9 TLR4 TLR2 IL6 IL2RA
2
Akt Signaling 63
Show member pathways
 13.51 TNF TLR9 TLR4 TLR2 IL6 IL2RA
3
Cytokine Signaling in Immune system 65
Show member pathways
 13.4 TNF IL6 IL2RA IL2 IL1B CXCL8
4
PAK Pathway 63
Show member pathways
 13.35 TNF IL6 IL2RA IL2 IL1B CXCL8
5
IL-2 Pathway 63
Show member pathways
 13.27 TNF TLR9 TLR4 TLR2 IL2RA IL2
6
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.16 TNF TLR9 TLR4 TLR2 IL6 IL2
7
PI3K-Akt signaling pathway 36
Show member pathways
 13.05 TNF TLR4 TLR2 IL6 IL2RA IL2
8
Human cytomegalovirus infection 36
Show member pathways
 13.03 TNF TLR4 TLR2 IL6 IL1B CXCL8
9
Allograft rejection 1 36
Show member pathways
 12.92 TNF IL6 IL2RA IL2 IL1B HSPD1
10
Measles 36
Show member pathways
 12.87 TNF TLR9 TLR4 TLR2 IL6 IL2RA
11
Herpes simplex virus 1 infection 36
12.84 TNF TLR9 TLR2 IL6 IL1B
12
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.84 TNF TLR9 TLR4 TLR2 IL6 IL1B
13
NF-KappaB Family Pathway 63
Show member pathways
 12.81 TNF TLR9 TLR4 TLR2 IL6 IL2
14
Th17 cell differentiation 36
Show member pathways
 12.7 TNF TLR4 TLR2 IL6 IL2RA IL2
15
NF-kappaB Signaling 4
12.68 TNF TLR9 TLR2 IL2RA IL2 IL1B
16
Immune response IL-23 signaling pathway 22
Show member pathways
 12.66 TNF IL6 IL2 IL1B CD4
17
TRAF Pathway 63
Show member pathways
 12.65 TNF TLR9 TLR4 TLR2 IL1B
18
T cell receptor signaling pathway 36
Show member pathways
 12.6 TNF TLR9 TLR4 TLR2 IL6 IL2
19
Human T-cell leukemia virus 1 infection 36
12.46 TNF IL6 IL2RA IL2 CDKN2A CD4
20
IL-17 Family Signaling Pathways 64
Show member pathways
 12.45 TNF TLR2 IL6 IL1B DEFB4A CXCL8
21
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.44 TNF IL6 IL2RA IL2 CXCL8
22
Shigellosis 36
12.43 TNF TLR4 IL1B CXCL8
23
Salmonella infection (KEGG) 36
12.43 TNF TLR9 TLR4 TLR2 IL6 IL1B
24
Toll Comparative Pathway 63
Show member pathways
 12.41 TNF TLR4 IL6 IL1B CXCL8
25
Folate Metabolism 1
Show member pathways
 12.38 TNF IL6 IL2 IL1B
26
Pathogenic Escherichia coli infection 36
12.38 TNF TLR4 IL6 IL1B CXCL8
27
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.38 TNF IL6 IL2RA IL2 IL1B CXCL8
28
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.38 TNF TLR9 TLR4 TLR2 IL6 CXCL8
29
Proteoglycans in cancer 36
12.36 TNF TLR4 TLR2 MIR21
30
NOD-like receptor signaling pathway 36
12.36 TNF TLR4 IL6 IL1B DEFB4A CXCL8
31
C-type lectin receptor signaling pathway 36
Show member pathways
 12.33 TNF TLR9 IL6 IL2 IL1B
32
Toxoplasmosis 36
Show member pathways
 12.32 TNF TLR4 TLR2 IL1B
33
Colorectal Cancer Metastasis 63
12.3 TNF TLR9 TLR4 TLR2 IL6
34
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.29 TNF IL6 IL1B HSPD1 CXCL8
35
Tuberculosis 36
12.29 TNF TLR9 TLR4 TLR2 IL6 IL1B
36
MAPK Pathway 70
Show member pathways
 12.17 TLR9 TLR4 TLR2 IL2RA IL2 IL1B
37
Yersinia infection 36
12.15 TNF TLR4 IL6 IL2 IL1B CXCL8
38
Spinal Cord Injury 1
12.14 TNF TLR4 IL6 IL2 IL1B CXCL8
39
Bacterial infections in CF airways 22
Show member pathways
 12.14 TNF TLR9 TLR4 TLR2 IL6 IL1B
40
IL12-mediated signaling events 1
Show member pathways
 12.12 IL2RA IL2 IL1B CD8A CD4
41
Interleukin-4 and 13 signaling 65
12.08 TNF IL6 IL1B CXCL8
42
Amoebiasis 36
12.05 TNF TLR4 TLR2 IL6 IL1B CXCL8
43
Senescence and Autophagy in Cancer 1
12.04 IL6 IL1B CXCL8 CDKN2A
44
Hematopoietic Stem Cells and Lineage-specific Markers 64
12.04 TNF IL6 IL2RA IL2 GP5 CD8A
45
NF-kappa B signaling pathway 36
12.03 TNF TLR4 IL1B CXCL8
46
AGE-RAGE signaling pathway in diabetic complications 36
12.01 TNF IL6 IL1B CXCL8
47
Rheumatoid arthritis 36
11.99 TNF TLR4 TLR2 IL6 IL1B CXCL8
48
Th17 Differentiation 64
Show member pathways
 11.97 TLR9 TLR4 TLR2 IL6 IL1B CD4
49
Hematopoietic cell lineage 36
11.91 TNF IL6 IL2RA IL1B GP5 CD8A
50
Pertussis 36
11.89 TNF TLR4 IL6 IL1B CXCL8
Sources

GO Terms for Cervicitis

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Cellular components related to Cervicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.65 TNF TLR4 IL2RA CD8A CD4
2 extracellular space GO:0005615 9.61 TNF SERPIND1 MIR21 IL6 IL2 IL1B
3 cell surface GO:0009986 9.17 TNF TLR4 TLR2 IL2RA HSPD1 GP6
4 lipopolysaccharide receptor complex GO:0046696 9.16 TLR4 HSPD1

Biological processes related to Cervicitis according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.28 TNF TLR9 TLR4 TLR2 IL6 IL2
2 immune system process GO:0002376 10.21 TLR9 TLR4 TLR2 IL2RA IL2 CD8A
3 negative regulation of cell proliferation GO:0008285 10.13 TLR2 MIR21 IL6 IL1B CXCL8 CDKN2A
4 positive regulation of apoptotic process GO:0043065 10.11 TNF MIR21 IL6 HSPD1 CDKN2A
5 positive regulation of gene expression GO:0010628 10.11 TNF TLR9 TLR4 TLR2 MIR21 IL6
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.04 TNF TLR4 MIR21 CD4
7 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.04 TNF TLR9 TLR4 IL1B CD4
8 cytokine-mediated signaling pathway GO:0019221 10.04 TNF IL6 IL2RA IL2 IL1B CXCL8
9 positive regulation of protein phosphorylation GO:0001934 10.03 TNF MIR21 IL2 IL1B CD4
10 inflammatory response GO:0006954 10.03 TNF TLR9 TLR4 TLR2 IL6 IL2RA
11 response to lipopolysaccharide GO:0032496 10.02 TLR4 TLR2 IL1B HSPD1
12 cellular response to lipopolysaccharide GO:0071222 10.02 TNF TLR4 MIR21 IL6 IL1B CXCL8
13 positive regulation of NF-kappaB transcription factor activity GO:0051092 10 TNF TLR9 TLR4 TLR2 IL6 IL1B
14 defense response to Gram-positive bacterium GO:0050830 9.98 TNF TLR2 IL6 DEFB4A
15 defense response to Gram-negative bacterium GO:0050829 9.97 TLR9 TLR4 IL6 DEFB4A CD4
16 positive regulation of JNK cascade GO:0046330 9.95 TNF TLR9 TLR4 IL1B
17 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.91 TNF IL6 IL2
18 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.91 TNF TLR9 TLR4
19 response to glucocorticoid GO:0051384 9.91 TNF IL6 HSPD1
20 hemostasis GO:0007599 9.9 SERPIND1 GP6 GP5
21 positive regulation of tumor necrosis factor production GO:0032760 9.89 TLR9 TLR4 TLR2
22 T cell activation GO:0042110 9.89 HSPD1 CD8A CD4
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.89 TNF TLR4 TLR2 IL1B
24 positive regulation of epithelial to mesenchymal transition GO:0010718 9.88 MIR21 IL6 IL1B
25 toll-like receptor signaling pathway GO:0002224 9.88 TLR9 TLR4 TLR2
26 positive regulation of nitric oxide biosynthetic process GO:0045429 9.88 TNF TLR4 IL1B
27 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.88 TLR9 TLR4 TLR2 HSPD1
28 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.88 TNF TLR9 TLR4 TLR2 IL1B
29 positive regulation of B cell proliferation GO:0030890 9.87 TLR9 TLR4 IL2
30 negative regulation of interleukin-6 production GO:0032715 9.87 TNF TLR9 TLR4
31 positive regulation of interleukin-12 production GO:0032735 9.87 TLR9 TLR4 TLR2 HSPD1
32 positive regulation of interleukin-10 production GO:0032733 9.86 TLR9 TLR4 TLR2 HSPD1
33 negative regulation of neurogenesis GO:0050768 9.85 TNF IL6 IL1B
34 positive regulation of activated T cell proliferation GO:0042104 9.85 MIR21 IL2RA IL2
35 positive regulation of interferon-beta production GO:0032728 9.85 TLR9 TLR4 TLR2
36 positive regulation of T cell proliferation GO:0042102 9.85 IL6 IL2RA IL2 IL1B CD4
37 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.84 TNF TLR4 MIR21 IL6
38 positive regulation of glial cell proliferation GO:0060252 9.82 TNF IL6 IL1B
39 positive regulation of interleukin-8 secretion GO:2000484 9.82 TNF TLR4 TLR2
40 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.8 TNF MIR21 IL6
41 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.8 TLR9 TLR4 TLR2
42 positive regulation of interferon-gamma production GO:0032729 9.8 TNF TLR4 IL2 IL1B HSPD1
43 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.79 TNF TLR9 TLR4
44 positive regulation of neuroinflammatory response GO:0150078 9.79 TNF IL6 IL1B
45 I-kappaB phosphorylation GO:0007252 9.78 TLR9 TLR4 TLR2
46 response to molecule of bacterial origin GO:0002237 9.77 TLR9 TLR2 CXCL8
47 positive regulation of interleukin-6 secretion GO:2000778 9.77 TNF TLR4 TLR2 IL1B HSPD1
48 interleukin-2-mediated signaling pathway GO:0038110 9.74 IL2RA IL2
49 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.74 TLR9 IL1B
50 cellular response to lipoteichoic acid GO:0071223 9.74 TLR4 TLR2

Molecular functions related to Cervicitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide receptor activity GO:0001875 9.16 TLR4 TLR2
2 lipopolysaccharide binding GO:0001530 9.13 TLR4 TLR2 HSPD1
3 cytokine activity GO:0005125 9.02 TNF IL6 IL2 IL1B CXCL8
Sources

Sources for Cervicitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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