Cervix Disease

Categories: Reproductive diseases

Aliases & Classifications for Cervix Disease

MalaCards integrated aliases for Cervix Disease:

Name: Cervix Disease 12 15
Uterine Cervical Diseases 44
Cervix Disorders 43
Cervix Diseases 73


External Ids:

Disease Ontology 12 DOID:2253
MeSH 44 D002577
NCIt 50 C40241
SNOMED-CT 68 63339007
UMLS 73 C0007867

Summaries for Cervix Disease

MedlinePlus : 43 The cervix is the lower part of the uterus, the place where a baby grows during pregnancy. The cervix has a small opening that expands during childbirth. It also allows menstrual blood to leave a woman's body. Your health care provider may perform a Pap test during your health checkup to look for changes to the cells of the cervix, including cervical cancer. Other problems with the cervix include: Cervicitis - inflammation of the cervix. This is usually from an infection. Cervical incompetence - This can happen during pregnancy. The opening of the cervix widens long before the baby is due. Cervical polyps and cysts - abnormal growths on the cervix

MalaCards based summary : Cervix Disease, also known as uterine cervical diseases, is related to cervical polyp and cervicitis, and has symptoms including pelvic pain An important gene associated with Cervix Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Small cell lung cancer and Viral carcinogenesis. The drugs Doxycycline and Lymecycline have been mentioned in the context of this disorder. Affiliated tissues include cervix, testes and uterus, and related phenotypes are cellular and homeostasis/metabolism

Disease Ontology : 12 A uterine disease that is located in the cervix.

Related Diseases for Cervix Disease

Diseases related to Cervix Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 cervical polyp 10.9
2 cervicitis 10.9
3 cervix erosion 10.9
4 cervix endometriosis 10.9
5 uterine cervix leukoplakia 10.9
6 cervical incompetence 10.9
7 bartholin's duct cyst 10.3 SMUG1 TP53
8 early invasive cervical adenocarcinoma 10.3 CDKN2A INSM1
9 male reproductive system disease 10.3 CASP3 TLR9 TP53
10 short-rib thoracic dysplasia 4 with or without polydactyly 10.3 CASP3 TP53
11 malignant spiradenoma 10.3 SMUG1 TP53
12 cellular ependymoma 10.3 SMUG1 TP53
13 tongue disease 10.3 CDKN2A TLR9 TP53
14 chronic cervicitis 10.3 GP6 SERPIND1 TLR9
15 microinvasive cervical squamous cell carcinoma 10.3 INSM1 PTPRN
16 bladder squamous cell carcinoma 10.3 CDKN2A TP53
17 protoplasmic astrocytoma 10.3 SMUG1 TP53
18 pharynx squamous cell carcinoma 10.3 CASP3 SMUG1
19 cervical adenosarcoma 10.3 GP5 GP6
20 penile disease 10.3 CDKN2A GP6 TP53
21 keratinizing squamous cell carcinoma 10.3 CDKN2A TP53
22 colloid adenoma 10.3 SMUG1 TP53
23 laryngeal disease 10.3 CDKN2A SERPIND1 TP53
24 megaesophagus 10.3 CDKN2A FHIT TP53
25 upper respiratory tract disease 10.3 CDKN2A TLR9 TP53
26 cerebral lymphoma 10.3 SMUG1 TLR9
27 oropharynx cancer 10.3 CDKN2A SMUG1 TP53
28 esophageal disease 10.3 CDKN2A SMUG1 TP53
29 spitz nevus 10.3 CDKN2A TP53
30 barrett's adenocarcinoma 10.3 CDKN2A FHIT TP53
31 supratentorial cancer 10.3 CASP3 CDKN2A TP53
32 vulvar disease 10.3 CDKN2A GP5 TP53
33 cerebrum cancer 10.3 CASP3 CDKN2A TP53
34 male reproductive organ cancer 10.3 CASP3 TLR9 TP53
35 colonic disease 10.3 CASP3 TLR9 TP53
36 skin melanoma 10.3 CASP3 CDKN2A TP53
37 rectal disease 10.3 CDKN2A GP5 TLR9
38 stomach disease 10.3 CASP3 TLR9 TP53
39 inverted follicular keratosis 10.3 GP5 GP6
40 tongue cancer 10.3 CASP3 CDKN2A TP53
41 oral cancer 10.3 CASP3 CDKN2A TP53
42 endocervical carcinoma 10.3 CDKN2A MAPK8IP1
43 anus disease 10.3 CDKN2A GP5 SMUG1
44 nervous system cancer 10.3 CASP3 CDKN2A TP53
45 focal epithelial hyperplasia 10.3 GP5 GP6 TP53
46 bladder carcinoma in situ 10.3 CDKN2A TP53
47 fallopian tube adenocarcinoma 10.3 INSM1 MAPK8IP1 PTPRN
48 fallopian tube endometrioid adenocarcinoma 10.3 CDKN2A INSM1 PTPRN
49 ameloblastic carcinoma 10.3 CDKN2A MAPK8IP2
50 anogenital venereal wart 10.3 CDKN2A GP6 TP53 UBE3A

Graphical network of the top 20 diseases related to Cervix Disease:

Diseases related to Cervix Disease

Symptoms & Phenotypes for Cervix Disease

UMLS symptoms related to Cervix Disease:

pelvic pain

MGI Mouse Phenotypes related to Cervix Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10 ANXA8L1 CASP3 CDKN2A INSM1 MAPK8IP1 PAX1
2 homeostasis/metabolism MP:0005376 9.83 CASP3 CDKN2A FHIT GP5 GP6 INSM1
3 endocrine/exocrine gland MP:0005379 9.81 CASP3 CDKN2A INSM1 MAPK8IP1 MAPK8IP2 PAX1
4 mortality/aging MP:0010768 9.47 CASP3 CDKN2A FHIT GP6 INSM1 MAPK8IP1

Drugs & Therapeutics for Cervix Disease

Drugs for Cervix Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 434)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 447043
Cisplatin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 15663-27-1 2767 441203 84093
Dopamine Approved Phase 4,Phase 2,Not Applicable 51-61-6, 62-31-7 681
Bupropion Approved Phase 4,Phase 2 34841-39-9, 34911-55-2 444
Nicotine Approved Phase 4,Not Applicable 54-11-5 942 89594
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
Iron Approved Phase 4,Phase 1,Phase 2 7439-89-6 23925
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
Chloroprocaine Approved Phase 4 133-16-4 8612
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
Ferrous fumarate Approved Phase 4 141-01-5
Vitamin C Approved, Nutraceutical Phase 4,Phase 2 50-81-7 5785 54670067
16 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
17 Antimalarials Phase 4,Phase 1
18 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
19 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
20 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
21 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
22 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
23 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
24 Liver Extracts Phase 4,Phase 2,Phase 1,Not Applicable
25 Psychotropic Drugs Phase 4,Phase 3,Phase 2
26 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
27 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
28 Epoetin alfa Phase 4,Phase 3 113427-24-0
29 Hematinics Phase 4,Phase 3,Phase 2,Phase 1
30 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
31 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
32 Analgesics Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1
33 Fluorodeoxyglucose F18 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Antidepressive Agents Phase 4,Phase 2
35 Antidepressive Agents, Second-Generation Phase 4,Phase 2
36 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2
37 Dopamine Uptake Inhibitors Phase 4,Phase 2,Not Applicable
38 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2,Not Applicable
39 Dopamine Agents Phase 4,Phase 2,Not Applicable
40 Cytochrome P-450 CYP2D6 Inhibitors Phase 4,Phase 2
41 Nicotinic Agonists Phase 4,Not Applicable
42 Cholinergic Agents Phase 4,Not Applicable
43 Autonomic Agents Phase 4,Phase 2,Phase 3,Not Applicable
44 Central Nervous System Stimulants Phase 4,Phase 2,Not Applicable
45 Anesthetics, Local Phase 4,Phase 3,Phase 2,Not Applicable
46 Analgesics, Opioid Phase 4,Not Applicable
47 Adjuvants, Anesthesia Phase 4
48 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Anesthetics, Intravenous Phase 4,Not Applicable
50 Narcotics Phase 4,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 1106)
# Name Status NCT ID Phase Drugs
1 Comparing Health Services Interventions for the Prevention of HPV-related Cancer Unknown status NCT02837926 Phase 4
2 Can Alternative Treatment Have an Impact on Cervical Dysplasia? Unknown status NCT00842738 Phase 4
3 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
4 Does the HPV Vaccine Cause the Same Response in Adolescent Kidney and Liver Transplant Patients as in Healthy Controls? Unknown status NCT01101750 Phase 4
5 Primary and Secondary Prevention of Human Papillomavirus (HPV) Disease in China Unknown status NCT01021904 Phase 4
6 Application of Tachosil During Lymphadenectomy Completed NCT03752606 Phase 4
7 The Use of 18F-ALF-NOTA-PRGD2 PET/CT Scan to Predict the Efficacy and Adverse Events of Apatinib in Malignancies. Completed NCT03384511 Phase 4 Apatinib
8 Effect of HPV Vaccination on Women Aged 25 Years Completed NCT02296255 Phase 4
9 V501 Safety and Efficacy Study in Japanese Women Aged 16 to 26 Years (V501-110) Completed NCT01544478 Phase 4
10 Delivery, Uptake and Acceptability of HPV Vaccination in Tanzanian Girls Completed NCT01173900 Phase 4
11 Management of Cervical Intraepithelial Neoplasia Grade 2 Completed NCT00733109 Phase 4
12 Immune Response to the Human Papillomavirus Vaccine in Young Women With Inflammatory Bowel Disease Completed NCT01034358 Phase 4
13 Alternate Dosing Schedules Study for HPV Vaccine Completed NCT00862810 Phase 4
14 Patient Navigation in the Safety Net:CONNECTeDD Completed NCT00613275 Phase 4
15 Health Education Counseling With or Without Bupropion in Helping African Americans Stop Smoking Completed NCT00666978 Phase 4 bupropion hydrochloride
16 Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking Completed NCT00365508 Phase 4 nicotine lozenge;nicotine patch
17 Epoetin Beta in Treating Anemia in Patients With Cervical Cancer Completed NCT00046969 Phase 4 cisplatin
18 Intrathecal Chloroprocaine vs. Bupivacaine for Cervical Cerclage Recruiting NCT03305575 Phase 4 Chloroprocaine;Bupivacaine
19 Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal) Recruiting NCT02862912 Phase 4 Chloroprocaine;Bupivacaine;Fentanyl;Saline
20 Pilot Study to Assess the Potential Clinical Utility of 18F Fluciclovine PET for Cervical and Endometrial Cancer. Recruiting NCT03423082 Phase 4 18F fluciclovine
21 Scientific Evaluation of One or Two Doses of the Bivalent or Nonavalent Prophylactic HPV Vaccines Recruiting NCT03180034 Phase 4
22 HPV Vaccine Therapy in Interrupting Progression in Patients With High-Grade Vulvar or Anal Lesions Recruiting NCT03051516 Phase 4
23 The Efficacy of Tachosil® for Prevention of Hemorrhage After Loop Electrosurgical Excisional Procedure (LEEP) Active, not recruiting NCT02629510 Phase 4 Tachosil
24 CervIcal Cancer Screening Trial by Randomization of HPV Testing Intervention for Upcoming Screening (CITRUS Study) Active, not recruiting NCT01895517 Phase 4
25 Oral Iron vs. Placebo in Newly Diagnosed Gynecologic Oncology Patients Who Are Surgical Candidates. Active, not recruiting NCT01953107 Phase 4
26 Trial of Two Versus Three Doses of Human Papillomavirus (HPV) Vaccine in India Active, not recruiting NCT00923702 Phase 4
27 Effectiveness of Cervical Screening in HPV Vaccinated Women Enrolling by invitation NCT02149030 Phase 4
28 Evaluation of Fluciclovine Uptake in Patients With Cervical, Ovarian Epithelial or Endometrial Cancers. Not yet recruiting NCT03349463 Phase 4 Fluciclovine F18
29 To Evaluate the Efficacy and Safety of PEG-rhG-CSF(Jinyouli®) in Reducing Neutropenia in Patients With Cervical Cancer Not yet recruiting NCT03206684 Phase 4 PEG-rhG-CSF;rhG-CSF
30 A Study to Assess the Safety and Reactogenicity of GlaxoSmithKline (GSK) Biologicals' Human Papillomavirus (HPV) Vaccine (Cervarix) in Healthy Female Filipino Subjects Vaccinated According to the Prescribing Information From the Age of 10 Years Onwards. Terminated NCT00730847 Phase 4
31 Dissemination of Cervical Cancer Screening to Primary Care Physicians in Underserved Communities Terminated NCT00629993 Phase 4
32 IT-system Development for Reaching Cervix Cancer Screening Non-attenders Unknown status NCT02750124 Phase 2, Phase 3
33 Evaluation of TRANSKRIP ® Plus Chemotherapy in Recurrent-Persistent Cervical Cancer Unknown status NCT02446652 Phase 3 Hydralazine/Magnesium;Placebo;Carboplatin;Paclitaxel
34 Evaluation of Postoperative Radiotherapy and Concurrent Chemotherapy Effectiveness in Cervical Cancer Unknown status NCT01999933 Phase 2, Phase 3 cisplatin(DDP) weekly;docetaxel plus cisplatin;docetaxel plus cisplatin
35 Study on Early Stage Bulky Cervical Cancers Unknown status NCT01917695 Phase 3 Chemotherapy
36 Postoperative Chemoradiation v.s Radiotherapy for Lymph Node Negative Cervical Cancer Patients Unknown status NCT01756170 Phase 3 paclitaxel;cisplatin
37 Trial of Postoperative Chemoradiotherapy With or Without Consolidation Chemotherapy for Cervical Cancer Patients Unknown status NCT01755845 Phase 3 paclitaxel;cisplatin
38 Study With Intensity Modulated Radiation Therapy With Cisplatin to Treat Stage I-IVA Cervical Cancer Unknown status NCT01554397 Phase 2, Phase 3 Cisplatin
39 Study on Paclitaxel Plus Topotecan in Comparison With Topotecan Plus Cisplatin in Recurrent or Persistent Cervical Carcinoma Unknown status NCT01405235 Phase 3 Paclitaxel;Cisplatin/Paclitaxel
40 Comparing Study Between Concurrent Chemoradiation and New Combination Treatment in Cervical Cancer Patients Unknown status NCT01000415 Phase 3
41 Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer Unknown status NCT01087268 Phase 3
42 Cisplatin Based Chemoradiation v.s Radiotherapy for Cervical Cancer and With Clinically Defined Good Prognosis Unknown status NCT00846508 Phase 3 Cisplatin
43 Radiotherapy With Single-Agent Cisplatin or Combination Chemotherapy in Defined Poor-Prognostic Cervical Cancer Unknown status NCT00842660 Phase 3 Gemzar (gemcitabine)
44 The Assessment of Preoperative Psychological Intervention on Stress in Women With Gynecological Malignancies Unknown status NCT00726635 Phase 3
45 Randomized Trial Between Weekly and 5 Day 3 Weekly Cisplatin for Cervical Cancer Unknown status NCT00548821 Phase 3 Cisplatin
46 Hydralazine Valproate for Cervical Cancer Unknown status NCT00532818 Phase 3 Hydralazine and magnesium valproate;Placebo
47 Impact of Erythropoietin Administration During Definitive Cervix Cancer Radiotherapy on Treatment Outcome Unknown status NCT00348738 Phase 3 Erythropoietin
48 Usefulness of FDG-PET for Advanced Cervical Cancer Unknown status NCT00146458 Phase 3
49 Clinical and Experimental Studies to Improve Radiotherapy Outcome in AIDS Cancer Patients Unknown status NCT00122746 Phase 3
50 The IMAP Study Improving Management of Mildly Abnormal Pap Smears Unknown status NCT00119509 Phase 3

Search NIH Clinical Center for Cervix Disease

Cochrane evidence based reviews: uterine cervical diseases

Genetic Tests for Cervix Disease

Anatomical Context for Cervix Disease

MalaCards organs/tissues related to Cervix Disease:

Cervix, Testes, Uterus, Lung, Colon, Tongue, Breast

The Foundational Model of Anatomy Ontology organs/tissues related to Cervix Disease:

The Cervix

Publications for Cervix Disease

Variations for Cervix Disease

Expression for Cervix Disease

Search GEO for disease gene expression data for Cervix Disease.

Pathways for Cervix Disease

Pathways related to Cervix Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 CASP3 FHIT TP53
2 11.23 CASP3 CDKN2A TP53 UBE3A
3 11 CASP3 CDKN2A TP53
4 10.27 GP5 GP6

GO Terms for Cervix Disease

Biological processes related to Cervix Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.7 CDKN2A PAX1 PTPRN SCX TLR9 TP53
2 regulation of JNK cascade GO:0046328 9.37 MAPK8IP1 MAPK8IP2
3 negative regulation of B cell proliferation GO:0030889 9.32 CASP3 CDKN2A
4 replicative senescence GO:0090399 9.26 CDKN2A TP53
5 hemostasis GO:0007599 9.13 GP5 GP6 SERPIND1
6 sclerotome development GO:0061056 8.62 PAX1 SCX

Molecular functions related to Cervix Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.96 CASP3 CDKN2A
2 MAP-kinase scaffold activity GO:0005078 8.62 MAPK8IP1 MAPK8IP2

Sources for Cervix Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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