Aliases & Classifications for Cervix Disease

MalaCards integrated aliases for Cervix Disease:

Name: Cervix Disease 12 15
Uterine Cervical Diseases 44
Cervix Disorders 42
Cervix Diseases 70


External Ids:

Disease Ontology 12 DOID:2253
MeSH 44 D002577
NCIt 50 C40241
SNOMED-CT 67 63339007
UMLS 70 C0007867

Summaries for Cervix Disease

MedlinePlus : 42 The cervix is the lower part of the uterus, the place where a baby grows during pregnancy. The cervix has a small opening that expands during childbirth. It also allows menstrual blood to leave a woman's body. Your health care provider may perform a Pap test during your health checkup to look for changes to the cells of the cervix, including cervical cancer. Other problems with the cervix include: Cervicitis - inflammation of the cervix. This is usually from an infection. Cervical incompetence - This can happen during pregnancy. The opening of the cervix widens long before the baby is due. Cervical polyps and cysts - abnormal growths on the cervix

MalaCards based summary : Cervix Disease, also known as uterine cervical diseases, is related to cervical polyp and cervicitis, and has symptoms including pelvic pain An important gene associated with Cervix Disease is MIR196A1 (MicroRNA 196a-1), and among its related pathways/superpathways is MicroRNAs in cancer. The drugs Paclitaxel and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include cervix, uterus and bone.

Disease Ontology : 12 A uterine disease that is located in the cervix.

Wikipedia : 73 The cervix or cervix uteri (Latin, 'neck of the uterus') is the lower part of the uterus in the human... more...

Related Diseases for Cervix Disease

Diseases related to Cervix Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 185)
# Related Disease Score Top Affiliating Genes
1 cervical polyp 10.9
2 cervicitis 10.9
3 cervix erosion 10.9
4 cervix endometriosis 10.9
5 uterine cervix leukoplakia 10.9
6 cervical incompetence 10.9
7 esophagus adenocarcinoma 10.6 MIR21 MIR199A1 MIR196A1 MIR143
8 ovarian serous carcinoma 10.5 MIR214 MIR21 MIR200A MIR199A1 MIR143
9 retinal vascular disease 10.5 MIR21 MIR199A1 MIR17 H2AC18
10 extrinsic cardiomyopathy 10.5 MIR21 MIR199A1 MIR142 H2AC18
11 miyoshi muscular dystrophy 1 10.5 MIR34A MIR214 MIR21
12 muscle cancer 10.5 MIR9-1 MIR199A1 MIR196A1 MIR142 H2AC18
13 pre-malignant neoplasm 10.5 MIR17 MIR143 MIR142 H2AC18
14 autoimmune disease of gastrointestinal tract 10.5 MIR199A1 MIR196A1 MIR142 H2AC18
15 endocrine organ benign neoplasm 10.5 MIR21 MIR199A1 MIR142 H2AC18
16 in situ carcinoma 10.5 MIR17 MIR143 MIR142 H2AC18
17 bone resorption disease 10.5 MIR214 MIR199A1 MIR196A1 MIR142 H2AC18
18 aortic aneurysm 10.5 MIR21 MIR195 MIR15A
19 pleural cancer 10.5 MIR200A MIR17 MIR142 H2AC18
20 gallbladder disease 10.5 MIR205 MIR199A1 MIR196A1 MIR17 MIR143
21 colonic benign neoplasm 10.5 MIR15A MIR143 H2AC18
22 aortic disease 10.5 MIR21 MIR199A1 MIR195 MIR17 MIR15A
23 muscle tissue disease 10.5 MIR9-1 MIR199A1 MIR196A1 MIR142 H2AC18
24 thyroid gland disease 10.5 MIR9-1 MIR199A1 MIR17 MIR142 H2AC18
25 chromosomal duplication syndrome 10.5 MIR9-1 MIR486-1 MIR196A1 H2AC18
26 uveal disease 10.5 MIR9-1 MIR361 MIR199A1 MIR142 H2AC18
27 leukocyte disease 10.5 MIR21 MIR199A1 MIR196A1 MIR17 MIR142 H2AC18
28 infratentorial cancer 10.5 MIR9-1 MIR199A1 MIR196A1 MIR17 MIR142 H2AC18
29 oropharynx cancer 10.5 MIR9-1 MIR199A1 H2AC18
30 muscular disease 10.5 MIR9-1 MIR21 MIR199A1 MIR196A1 MIR142 H2AC18
31 bone remodeling disease 10.5 MIR214 MIR199A1 MIR142 H2AC18
32 melanoma in congenital melanocytic nevus 10.5 MIR214 MIR199A1 H2AC18
33 melanoma, uveal 10.5 MIR9-1 MIR224 MIR199A1 MIR143 H2AC18
34 malignant ovarian surface epithelial-stromal neoplasm 10.5 MIR9-1 MIR21 MIR200A MIR199A1 MIR196A1 MIR17
35 intrinsic cardiomyopathy 10.5 MIR486-1 MIR21 MIR199A1 MIR142 H2AC18
36 ovary epithelial cancer 10.5 MIR9-1 MIR21 MIR200A MIR199A1 MIR196A1 MIR17
37 renal fibrosis 10.5 MIR214 MIR21 MIR199A1 MIR196A1
38 bronchial disease 10.5 MIR21 MIR17 MIR142 H2AC18
39 lipid storage disease 10.5 MIR21 MIR199A1 MIR142 H2AC18
40 rectum cancer 10.5 MIR31 MIR214 MIR21 MIR200A MIR17 MIR143
41 mature t-cell and nk-cell lymphoma 10.5 MIR199A1 MIR17 H2AC18
42 aortic valve disease 2 10.5 MIR486-1 MIR34A MIR21 MIR199A1 MIR195 MIR17
43 cardiovascular organ benign neoplasm 10.5 MIR15A MIR143 H2AC18
44 dermatomyositis 10.5 MIR34A MIR214 MIR21
45 muscular dystrophy, duchenne type 10.5 MIR486-1 MIR361 MIR34A MIR214 MIR21
46 autoimmune disease of musculoskeletal system 10.5 MIR34A MIR21 MIR199A1 MIR196A1 MIR17 MIR142
47 bone inflammation disease 10.5 MIR34A MIR21 MIR199A1 MIR196A1 MIR17 MIR142
48 b-cell lymphoma 10.5 MIR34A MIR21 MIR17 MIR142
49 bile duct cancer 10.5 MIR9-1 MIR31 MIR21 MIR199A1 MIR17 H2AC18
50 mature b-cell neoplasm 10.5 MIR9-1 MIR361 MIR199A1 MIR196A1 MIR17 MIR142

Graphical network of the top 20 diseases related to Cervix Disease:

Diseases related to Cervix Disease

Symptoms & Phenotypes for Cervix Disease

UMLS symptoms related to Cervix Disease:

pelvic pain

Drugs & Therapeutics for Cervix Disease

Drugs for Cervix Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
3 Orange Approved Phase 2
4 Anesthetics Phase 2
5 Antimitotic Agents Phase 2
6 Albumin-Bound Paclitaxel Phase 2
7 Tubulin Modulators Phase 2
Chlorhexidine Approved, Vet_approved 55-56-1 9552079 2713
Dimenhydrinate Approved 523-87-5 441281
10 Sodium hypochlorite
11 Eusol
12 Anti-Infective Agents, Local
13 Chlorhexidine gluconate
14 Pharmaceutical Solutions
15 Anti-Infective Agents
16 Disinfectants
17 Hemostatics

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Noncarious Cervical Lesion Treatment Outcomes: Randomized Clinical Trial Completed NCT00867997 Phase 3
2 Influence of Operatory Field Isolation Techniques on the Clinical Performance of Class V Restorations Completed NCT01506830 Phase 2, Phase 3
3 Development and Application of a Diagnostic Imaging Aid for One-visit Management of Cervical Lesions in Low-resource Settings Unknown status NCT02406365 Phase 2
4 A Phase I/II, Open-Label, Multicenter, Two-Arm, Feasibility Study of Pazopanib, Carboplatin, and Paclitaxel in Women With Newly Diagnosed, Previously Untreated, Gynaecological Tumors Completed NCT00561795 Phase 2 pazopanib (GW786034);carboplatin;paclitaxel
5 Clinical Performance of a One-step Self-etch Adhesive in Non-carious Cervical Lesions at 2 Years Active, not recruiting NCT04565938 Phase 2
6 Initial Study With the CNDS Advanced Cervical Scan to Recalibrate Spectral Data for Use in Future Screening Studies Unknown status NCT02217215
7 Effect of Sodium Hypochlorite Pre-treatment on the Retention of Restorations for Non-carious Cervical Lesions: A Randomized Controlled Trial Unknown status NCT03086720
8 Evaluation of the Cobas® 4800 HPV Test for the Detection of High-grade Cervical Disease in Women Undergoing Routine Cervical Cancer Screening Completed NCT00709891
9 Release of Organic Components of a GIOMER in Non-carious Cervical Lesion Restorations: in Vitro and in Vivo Studies Completed NCT03637946
10 Effect of Surface Pre-conditioning With Bioactive Glass Air-abrasion on the Clinical Performance of Composite Restorations in Non-carious Cervical Lesions Completed NCT04578717
11 Chlorhexidine as Coadjuvant in Dentin Adhesion of Noncarious Cervical Lesions and Failure-prognostic Variables: A Randomized Controlled Trial Completed NCT01947192
12 36-Month Clinical Evaluation of Different Adhesive Strategies of a Universal Adhesive Completed NCT03932929
13 Clinical Evaluation of a Universal Adhesive in Noncarious Cervical Lesions Completed NCT02172664
14 See and Treat in an Outpatient Setting in Women Above 45 Years With Cervical Dysplasia Recruiting NCT04298957
15 Does Dynamic Spectral Imaging (DSI) Colposcopy Improve the Diagnostics of Cervical Dysplasia Compared to Standard Colposcopy Recruiting NCT04249856
16 The Comparison of Awake Fiberoptic And Awake Video Laryngoscopy Tracheal Recruiting NCT03734965
17 Reducing the Burden of Cervical Cancer Among Older Women by Expanding the Screening Age and Offering HPV Self-sampling Recruiting NCT04114968
18 Can SMS-reminders Result in Increased Participation in Cervical Screening? Recruiting NCT04061967
19 Randomized Blind Clinical Trial, Four-armed Parallel of Clinical Performance of Prime&Bond Active in Self-etch or Selective-etch With or Without Bioglass Active, not recruiting NCT03798184
20 24-Month Performance of a Glass-hybrid-restorative in Non-carious Cervical Lesions of Patients With Bruxism: A Split-mouth, Randomized Clinical Trial Active, not recruiting NCT03713827
21 Clinical Evaluation of Different Solvent-based Universal Adhesive Systems in Non-carious Cervical Lesions. Active, not recruiting NCT04707898
22 Clinical Performance of Adhesive Systems Containing HEMA and 10-MDP in Non Carious Cervical Lesions - A Two Years Randomized Double Blind Study Active, not recruiting NCT04756349
23 Self-Testing Options in the Era of Primary HPV Screening for Cervical Cancer: the STEP Trial Enrolling by invitation NCT04679675
24 Clinical Performance of Low Technique Sensitive Self-cured Universal Adhesive Versus Light Cured Universal Adhesive in Patients With Non-carious Cervical Lesions (NCCLs): 18 Month Randomized Clinical Trial Not yet recruiting NCT04572386
25 Benefit From a Proximity-incentive Strategy Based on Vaginal Self-sampling for Women Who do Not Participate to Cervical Cancer Screening in Aude and Hérault [French Departments]: an Interventional Research to Reduce Social and Territorial Inequalities. Not yet recruiting NCT04716127
26 A Prospective, Open-Label, Pilot, Multicentric Clinical Investigation to Evaluate the Performance and Safety of Cerviron® Ovules in Cervix Lesions Postoperative Care Not yet recruiting NCT04735718
27 A Pragmatic Randomized Control Trial Which Evaluates the Potential for HPV Self-testing to Promote Participation in Cervical Screening (PROMOTER) Trial Withdrawn NCT02779621
28 Clinical Evaluation of Four Aesthetic Restorations in Non-carious Cervical Lesions: a Randomised Controlled Split-mouth Clinical Trial Withdrawn NCT04261140

Search NIH Clinical Center for Cervix Disease

Cochrane evidence based reviews: uterine cervical diseases

Genetic Tests for Cervix Disease

Anatomical Context for Cervix Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Cervix Disease:


MalaCards organs/tissues related to Cervix Disease:

Cervix, Uterus, Bone, Heart, Lung, Skin, Prostate

Publications for Cervix Disease

Articles related to Cervix Disease:

(show all 15)
# Title Authors PMID Year
Hyperelastic Ex Vivo Cervical Tissue Mechanical Characterization. 42
32764345 2020
Impact of additional risk factors on the incidence of preterm delivery among pregnant women diagnosed with short cervix. 42
32127137 2020
Risk factors for spontaneous miscarriage above 12 weeks or premature delivery in patients undergoing cervical polypectomy during pregnancy. 42
31918700 2020
Clinical application of photodynamic diagnosis and photodynamic therapy for gynecologic malignant diseases: A review. 61
30172075 2018
Hindlimb lameness and gait abnormalities in bitches with pyometra. 61
24789856 2014
Loop electrosurgical excision procedure as a life event that impacts on postmenopausal women. 61
23279072 2013
Methylation of HPV16 genome CpG sites is associated with cervix precancer and cancer. 61
21306759 2011
Human telomerase RNA gene (TERC) gain and polysomy of chromosome 3 in cervicovaginal liquid-based pap preparations: a fluorescence in situ hybridization study. 61
20882876 2010
Gain of the human telomerase RNA gene TERC at 3q26 is strongly associated with cervical intraepithelial neoplasia and carcinoma. 61
20009881 2009
[Preoperative concomitant radiochemotherapy in bulky carcinoma of the cervix: Institut Curie experience]. 61
19524469 2009
Pre-operative Concomitant Radio-chemotherapy in Bulky Carcinoma of the Cervix: A Single Institution Study. 61
21892284 2008
Uterine transplantation: a future possibility to treat women with uterus factor infertility? 61
17592442 2007
DNA-EIA to detect high and low risk HPV genotypes in cervical lesions with E6/E7 primer mediated multiplex PCR. 61
9577370 1998
Human papillomavirus, human cytomegalovirus and oncogene C-myc in cervical carcinoma and cervicitis. 61
8391967 1993
[Leukoplasic cervix disease associated with primary sterility]. 61
5747090 1968

Variations for Cervix Disease

Expression for Cervix Disease

Search GEO for disease gene expression data for Cervix Disease.

Pathways for Cervix Disease

Pathways related to Cervix Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.96 MIR9-1 MIR34A MIR31 MIR224 MIR214 MIR21

GO Terms for Cervix Disease

Cellular components related to Cervix Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular vesicle GO:1903561 9.43 MIR34A MIR214 MIR21 MIR17 MIR15A MIR101-1
2 extracellular space GO:0005615 9.4 MIR486-1 MIR361 MIR31 MIR224 MIR21 MIR205

Biological processes related to Cervix Disease according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 10.01 MIR9-1 MIR214 MIR21 MIR195 MIR15A
2 negative regulation of gene expression GO:0010629 9.92 MIR34A MIR214 MIR21 MIR17 MIR101-1
3 positive regulation of angiogenesis GO:0045766 9.87 MIR31 MIR21 MIR199A1 MIR143
4 negative regulation of cell migration GO:0030336 9.86 MIR9-1 MIR34A MIR214 MIR21
5 cellular response to hypoxia GO:0071456 9.81 MIR34A MIR214 MIR17
6 negative regulation of inflammatory response GO:0050728 9.81 MIR31 MIR205 MIR15A MIR142
7 negative regulation of angiogenesis GO:0016525 9.8 MIR361 MIR34A MIR214 MIR21 MIR15A MIR143
8 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.76 MIR214 MIR21 MIR17
9 positive regulation of blood vessel endothelial cell migration GO:0043536 9.75 MIR31 MIR200A MIR143
10 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.73 MIR361 MIR199A1 MIR196A1 MIR15A
11 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.72 MIR34A MIR214 MIR15A
12 miRNA mediated inhibition of translation GO:0035278 9.7 MIR9-1 MIR31 MIR21 MIR205 MIR17 MIR15A
13 negative regulation of amyloid precursor protein biosynthetic process GO:0042985 9.67 MIR31 MIR17 MIR101-1
14 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.67 MIR34A MIR214 MIR21 MIR15A
15 positive regulation of cardiac muscle cell apoptotic process GO:0010666 9.65 MIR34A MIR195 MIR17
16 negative regulation of necroptotic process GO:0060546 9.63 MIR214 MIR101-1
17 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.63 MIR214 MIR199A1 MIR17
18 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.62 MIR199A1 MIR17
19 cell growth involved in cardiac muscle cell development GO:0061049 9.62 MIR199A1 MIR195
20 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.61 MIR21 MIR17
21 negative regulation of fibroblast growth factor production GO:0090272 9.6 MIR205 MIR195
22 gene silencing by miRNA GO:0035195 9.6 MIR9-1 MIR518A1 MIR486-1 MIR361 MIR34A MIR31
23 negative regulation of lamellipodium assembly GO:0010593 9.59 MIR214 MIR196A1
24 positive regulation of metalloendopeptidase activity GO:1904685 9.58 MIR21 MIR205 MIR17
25 positive regulation of connective tissue replacement GO:1905205 9.56 MIR34A MIR214 MIR199A1 MIR195
26 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.54 MIR17 MIR143
27 negative regulation of vascular endothelial growth factor production GO:1904046 9.5 MIR361 MIR34A MIR205 MIR199A1 MIR195 MIR17

Molecular functions related to Cervix Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.73 MIR9-1 MIR361 MIR34A MIR31 MIR21 MIR205
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.58 MIR9-1 MIR518A1 MIR361 MIR34A MIR31 MIR224

Sources for Cervix Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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