MCID: CRV022
MIFTS: 39

Cervix Small Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervix Small Cell Carcinoma

MalaCards integrated aliases for Cervix Small Cell Carcinoma:

Name: Cervix Small Cell Carcinoma 12 15
Small Cell Carcinoma of the Cervix 12 73
Small Cell Carcinoma of the Cervix Uteri 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6740
NCIt 50 C7982
UMLS 73 C0279674

Summaries for Cervix Small Cell Carcinoma

MalaCards based summary : Cervix Small Cell Carcinoma, also known as small cell carcinoma of the cervix, is related to small cell carcinoma and malignant sertoli cell tumor. An important gene associated with Cervix Small Cell Carcinoma is ENO2 (Enolase 2), and among its related pathways/superpathways are ERK Signaling and Adhesion. The drugs Cisplatin and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include cervix, lymph node and breast, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Cervix Small Cell Carcinoma

Diseases related to Cervix Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma 30.0 CHGA ENO2 NCAM1 SYP TP53
2 malignant sertoli cell tumor 11.0 ENO2 SYP
3 intracranial primitive neuroectodermal tumor 11.0 CHGA ENO2
4 sinonasal undifferentiated carcinoma 11.0 ENO2 SYP
5 multiple mucosal neuroma 10.9 ENO2 NCAM1
6 pancreatic somatostatinoma 10.9 ENO2 SYP
7 papillary tumor of the pineal region 10.9 ENO2 SYP
8 adenoma of the pancreas 10.9 CHGA SYP
9 acinar cell cystadenocarcinoma 10.9 CHGA SYP
10 lung meningioma 10.9 ENO2 NCAM1
11 peritoneal serous adenocarcinoma 10.9 CHGA SYP
12 middle ear adenoma 10.9 ENO2 SYP
13 primary hepatic neuroendocrine carcinoma 10.9 CHGA SYP
14 ovarian carcinosarcoma 10.9 ENO2 SYP
15 lung combined type small cell carcinoma 10.9 NCAM1 SYP
16 choriocarcinoma of ovary 10.9 ENO2 NCAM1
17 gastrointestinal neuroendocrine tumor 10.9 CHGA SYP
18 epithelioid malignant peripheral nerve sheath tumor 10.9 CHGA ENO2
19 goblet cell carcinoid 10.9 CHGA ENO2
20 lymphocytic hypophysitis 10.8 ENO2 POMC
21 chordoid meningioma 10.8 CHGA SYP
22 subependymal glioma 10.8 ENO2 SYP
23 hypoganglionosis 10.8 NCAM1 SYP
24 ureter small cell carcinoma 10.8 CHGA ENO2 SYP
25 urinary bladder small cell neuroendocrine carcinoma 10.8 CHGA ENO2 SYP
26 pancreatic endocrine carcinoma 10.8 NCAM1 SYP
27 auditory system cancer 10.8 CHGA ENO2 SYP
28 small cell carcinoma of the bladder 10.8 CHGA ENO2 SYP
29 pulmonary large cell neuroendocrine carcinoma 10.8 CHGA ENO2 SYP
30 cauda equina neoplasm 10.8 CHGA ENO2 SYP
31 nodular ganglioneuroblastoma 10.8 CHGA ENO2 SYP
32 pineocytoma 10.7 CHGA ENO2 SYP
33 respiratory system benign neoplasm 10.7 CHGA ENO2 SYP
34 brain stem astrocytic neoplasm 10.7 CDKN2A TP53
35 carcinoid tumors, intestinal 10.7 CHGA ENO2 SYP
36 papillary ependymoma 10.7 CHGA ENO2 SYP
37 sensory organ benign neoplasm 10.7 ENO2 NCAM1 SYP
38 cutaneous ganglioneuroma 10.7 ENO2 NCAM1 SYP
39 extrahepatic bile duct adenocarcinoma 10.7 ENO2 NCAM1 SYP
40 orbital cancer 10.7 ENO2 NCAM1 SYP
41 sclerosing hemangioma 10.7 CHGA ENO2 SYP
42 central neurocytoma 10.7 CHGA ENO2 SYP
43 sarcomatoid squamous cell skin carcinoma 10.7 MAPK8IP1 TP53
44 carcinoid syndrome 10.7 CHGA ENO2 SYP
45 olfactory groove meningioma 10.7 CHGA TP53
46 endometrial small cell carcinoma 10.7 ENO2 NCAM1 SYP
47 olfactory neuroblastoma 10.7 CHGA ENO2 SYP
48 horseshoe kidney 10.7 CHGA ENO2 SYP
49 endocervical carcinoma 10.7 CDKN2A MAPK8IP1
50 extraosseous chondrosarcoma 10.7 ENO2 SYP

Graphical network of the top 20 diseases related to Cervix Small Cell Carcinoma:



Diseases related to Cervix Small Cell Carcinoma

Symptoms & Phenotypes for Cervix Small Cell Carcinoma

MGI Mouse Phenotypes related to Cervix Small Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.96 NCAM1 AVP POMC SYP CDKN2A TAGLN
2 homeostasis/metabolism MP:0005376 9.9 MAPK8IP2 AVP POMC CDH2 CDKN2A TAGLN
3 mortality/aging MP:0010768 9.73 NCAM1 AVP POMC CDH2 CDKN2A TAGLN
4 nervous system MP:0003631 9.4 NCAM1 AVP POMC CDH2 SYP CDKN2A

Drugs & Therapeutics for Cervix Small Cell Carcinoma

Drugs for Cervix Small Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2,Phase 1 15663-27-1 84093 441203 2767
2
Lenograstim Approved, Investigational Phase 2 135968-09-1
3
Topotecan Approved, Investigational Phase 2 119413-54-6, 123948-87-8 60700
4
Paclitaxel Approved, Vet_approved Phase 2,Phase 1 33069-62-4 36314
5
Cetuximab Approved Phase 2,Phase 1 205923-56-4 56842117 2333
6
Veliparib Investigational Phase 2 912444-00-9 11960529
7 Antibodies Phase 2
8 Immunoglobulins Phase 2
9 Antibodies, Monoclonal Phase 2
10 topoisomerase I inhibitors Phase 2
11 Adjuvants, Immunologic Phase 2
12 Albumin-Bound Paclitaxel Phase 2,Phase 1
13 Topoisomerase Inhibitors Phase 2
14 Poly(ADP-ribose) Polymerase Inhibitors Phase 2
15 Antimitotic Agents Phase 2,Phase 1
16 Antineoplastic Agents, Phytogenic Phase 2,Phase 1
17 Fluorodeoxyglucose F18 Phase 1, Phase 2
18 Radiopharmaceuticals Phase 1, Phase 2
19
Gemcitabine Approved Phase 1 95058-81-4 60750
20 Immunosuppressive Agents Phase 1
21 Anti-Infective Agents Phase 1
22 Antimetabolites Phase 1
23 Antiviral Agents Phase 1
24 Antimetabolites, Antineoplastic Phase 1
25
Formaldehyde Approved, Vet_approved 50-00-0 712
26 interferons
27 Anti-Bacterial Agents
28 Antibiotics, Antitubercular
29 Interferon Inducers
30 Krestin
31 Protective Agents
32 Radiation-Protective Agents

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Panitumumab, Cisplatin, and Pelvic Radiation Therapy in Treating Patients With Stage IB, Stage II, or Stage III Cervical Cancer Unknown status NCT01158248 Phase 2 cisplatin
2 ABI-007 in Treating Patients With Persistent or Recurrent Cervical Cancer Completed NCT00309959 Phase 2 Paclitaxel Albumin-Stabilized Nanoparticle Formulation
3 Pelvic Exenteration in Treating Patients With Recurrent Cervical Cancer Completed NCT00217633 Phase 2
4 Veliparib, Topotecan Hydrochloride, and Filgrastim or Pegfilgrastim in Treating Patients With Persistent or Recurrent Cervical Cancer Completed NCT01266447 Phase 2 Topotecan Hydrochloride;Veliparib
5 Cetuximab and Cisplatin in Treating Patients With Advanced, Persistent, or Recurrent Cervical Cancer Completed NCT00101192 Phase 2 cisplatin
6 Paclitaxel, Topotecan, and Cisplatin in Treating Patients With Advanced, Persistent, or Recurrent Cervical Cancer Completed NCT00276796 Phase 2 cisplatin;paclitaxel;topotecan hydrochloride
7 Radiation Therapy Plus Paclitaxel and Cisplatin in Treating Patients With Cervical Cancer Completed NCT00003379 Phase 1, Phase 2 cisplatin;paclitaxel
8 Fludeoxyglucose F 18 PET Scan, CT Scan, and Ferumoxtran-10 MRI Scan Before Chemotherapy and Radiation Therapy in Finding Lymph Node Metastasis in Patients With Locally Advanced Cervical Cancer or High-Risk Endometrial Cancer Active, not recruiting NCT00416455 Phase 1, Phase 2 ferumoxtran-10
9 ADXS11-001 High Dose HPV+ Cervical Cancer Active, not recruiting NCT02164461 Phase 1, Phase 2
10 Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer Completed NCT00104910 Phase 1 Cisplatin
11 Radiation Therapy Plus Cisplatin and Gemcitabine in Treating Patients With Cervical Cancer Completed NCT00068549 Phase 1 Gemcitabine Hydrochloride;Cisplatin
12 Glycoprotein and Glycan in Tissue and Blood Samples of Patients With Stage IB-IVA Cervical Cancer Undergoing Surgery to Remove Pelvic and Abdominal Lymph Nodes Completed NCT00460356
13 Collecting Tumor Samples From Patients With Gynecological Tumors Completed NCT00897442
14 Use of Social Networking to Survey Women With Small and Large Cell Carcinomas of the Cervix Recruiting NCT01606293

Search NIH Clinical Center for Cervix Small Cell Carcinoma

Genetic Tests for Cervix Small Cell Carcinoma

Anatomical Context for Cervix Small Cell Carcinoma

MalaCards organs/tissues related to Cervix Small Cell Carcinoma:

41
Cervix, Lymph Node, Breast, Testes

Publications for Cervix Small Cell Carcinoma

Articles related to Cervix Small Cell Carcinoma:

(show all 20)
# Title Authors Year
1
Advanced small cell carcinoma of the cervix - Successful treatment with concurrent etoposide and cisplatin chemotherapy and extended field radiation: A case report and discussion. ( 29255785 )
2018
2
Lambert-Eaton Myasthenic Syndrome Associated with Synchronous Double Cancer: A Combination of Small Cell Carcinoma of the Cervix and Breast Carcinoma. ( 29526952 )
2018
3
The local treatment modalities in FIGO stage I-II small-cell carcinoma of the cervix are determined by disease stage and lymph node status. ( 26990881 )
2016
4
Prognostic risk factors for small cell carcinoma of the cervix and impact of platinum-based neoadjuvant chemotherapy. ( 25890393 )
2015
5
Adenocarcinoma of the cervix associated with a neuroendocrine small cell carcinoma of the cervix in the spectrum of Muir-Torre syndrome. ( 26050364 )
2015
6
Gynecologic Cancer InterGroup (GCIG) Consensus Review for Small Cell Carcinoma of the Cervix. ( 25341572 )
2014
7
Radiation sensitivity assay with a panel of patient-derived spheroids of small cell carcinoma of the cervix. ( 25408479 )
2014
8
Small cell carcinoma of the cervix in liquid-based Pap test: utilization of split-sample immunocytochemical and molecular analysis. ( 20891001 )
2012
9
Chromogranin A (CgA) as poor prognostic factor in patients with small cell carcinoma of the cervix: results of a retrospective study of 293 patients. ( 22529895 )
2012
10
Downregulation of six microRNAs is associated with advanced stage, lymph node metastasis and poor prognosis in small cell carcinoma of the cervix. ( 22438992 )
2012
11
Small cell carcinoma of the cervix: treatment and survival outcomes of 188 patients. ( 20579961 )
2010
12
Clinicopathological features and prognosis of small cell carcinoma of the cervix. ( 21063846 )
2010
13
Small-cell carcinoma of the cervix at 23 weeks gestation. ( 20385993 )
2010
14
Incidence, mortality, and prognostic factors of small cell carcinoma of the cervix. ( 18515524 )
2008
15
Small cell carcinoma of the cervix presenting with acute vaginal hemorrhage: a case report. ( 18455059 )
2008
16
Neuroendocrine small cell carcinoma of the cervix associated with endocervical adenocarcinoma: a case report. ( 17718130 )
2007
17
Expression of cadherins, p53, and BCL2 in small cell carcinomas of the cervix: potential tumor suppressor role for N-cadherin. ( 12657131 )
2003
18
Small cell carcinoma of the cervix: a clinicopathologic and immunohistochemical study of 23 cases. ( 12478483 )
2002
19
Overexpression of p53 protein and c-erbB-2 protein in small cell carcinoma of the cervix uteri. ( 8103676 )
1993
20
Eaton-Lambert syndrome as a harbinger of recurrent small-cell carcinoma of the cervix with improvement after combination chemotherapy. ( 2841632 )
1988

Variations for Cervix Small Cell Carcinoma

Cosmic variations for Cervix Small Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6932 TP53 cervix,NS,carcinoma,small cell carcinoma c.733G>A p.G245S 17:7674230-7674230 12
2 COSM145923 SF3B1 cervix,NS,carcinoma,small cell carcinoma c.2225G>A p.G742D 2:197401887-197401887 12
3 COSM6943414 RPS6KB2 cervix,NS,carcinoma,small cell carcinoma c.356A>C p.E119A 11:67431414-67431414 12
4 COSM6943412 RAD54L cervix,NS,carcinoma,small cell carcinoma c.388G>T p.D130Y 1:46260080-46260080 12
5 COSM763 PIK3CA cervix,NS,carcinoma,small cell carcinoma c.1633G>A p.E545K 3:179218303-179218303 12
6 COSM760 PIK3CA cervix,NS,carcinoma,small cell carcinoma c.1624G>A p.E542K 3:179218294-179218294 12
7 COSM3832368 KMT2C cervix,NS,carcinoma,small cell carcinoma c.4174C>T p.Q1392* 7:152199378-152199378 12
8 COSM125370 cervix,NS,carcinoma,small cell carcinoma c.1633G>A p.E545K 3:179218303-179218303 12
9 COSM6943413 cervix,NS,carcinoma,small cell carcinoma c.356A>C p.E119A 11:67431414-67431414 12
10 COSM3832367 cervix,NS,carcinoma,small cell carcinoma c.4174C>T p.Q1392* 7:152199378-152199378 12

Expression for Cervix Small Cell Carcinoma

Search GEO for disease gene expression data for Cervix Small Cell Carcinoma.

Pathways for Cervix Small Cell Carcinoma

Pathways related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.08 CDH17 CDH2 CDKN2A CXCL1 CXCR1 CXCR2
2 11.59 CDH17 CDH2 NCAM1
3 11.56 AVP ENO2 NCAM1 POMC SYP
4
Show member pathways
11.5 CXCL1 CXCR1 CXCR2
5 11.36 CDKN2A CXCL1 TP53

GO Terms for Cervix Small Cell Carcinoma

Cellular components related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 8.8 AVP CHGA POMC

Biological processes related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of JNK cascade GO:0046328 9.32 MAPK8IP1 MAPK8IP2
2 dendritic cell chemotaxis GO:0002407 9.26 CXCR1 CXCR2
3 replicative senescence GO:0090399 9.16 CDKN2A TP53
4 chemokine-mediated signaling pathway GO:0070098 9.13 CXCL1 CXCR1 CXCR2
5 interleukin-8-mediated signaling pathway GO:0038112 8.62 CXCR1 CXCR2

Molecular functions related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.55 CDH2 CDKN2A MAPK8IP1 MAPK8IP2 TP53
2 C-X-C chemokine receptor activity GO:0016494 9.32 CXCR1 CXCR2
3 MAP-kinase scaffold activity GO:0005078 9.26 MAPK8IP1 MAPK8IP2
4 interleukin-8 binding GO:0019959 8.96 CXCR1 CXCR2
5 interleukin-8 receptor activity GO:0004918 8.62 CXCR1 CXCR2

Sources for Cervix Small Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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