MCID: CRV022
MIFTS: 36

Cervix Small Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervix Small Cell Carcinoma

MalaCards integrated aliases for Cervix Small Cell Carcinoma:

Name: Cervix Small Cell Carcinoma 12 15
Small Cell Carcinoma of the Cervix 12 73
Small Cell Carcinoma of the Cervix Uteri 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6740
NCIt 50 C7982
UMLS 73 C0279674

Summaries for Cervix Small Cell Carcinoma

MalaCards based summary : Cervix Small Cell Carcinoma, also known as small cell carcinoma of the cervix, is related to small cell carcinoma and extraosseous chondrosarcoma. An important gene associated with Cervix Small Cell Carcinoma is ENO2 (Enolase 2), and among its related pathways/superpathways are ERK Signaling and Adhesion. The drugs Cisplatin and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include cervix, ovary and lung, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Cervix Small Cell Carcinoma

Diseases related to Cervix Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 182)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma 30.3 CDKN2A CHGA ENO2 NCAM1 SYP TP53
2 extraosseous chondrosarcoma 10.3 ENO2 SYP
3 subependymal glioma 10.3 ENO2 SYP
4 pineal gland cancer 10.3 ENO2 SYP
5 clear cell ependymoma 10.3 ENO2 SYP
6 astroblastoma 10.3 ENO2 SYP
7 goblet cell carcinoid 10.3 CHGA ENO2
8 middle cerebral artery infarction 10.3 ENO2 NCAM1
9 chordoid meningioma 10.3 CHGA SYP
10 supratentorial primitive neuroectodermal tumor 10.3 NCAM1 SYP
11 hypoganglionosis 10.3 NCAM1 SYP
12 endocervical carcinoma 10.3 CDKN2A MAPK8IP1
13 sella turcica neoplasm 10.3 POMC SYP
14 tuberculum sellae meningioma 10.3 POMC SYP
15 carotid body cancer 10.3 ENO2 SYP
16 pituitary carcinoma 10.3 CHGA POMC
17 ureter small cell carcinoma 10.3 CHGA SYP
18 malignant sertoli cell tumor 10.3 ENO2 SYP
19 intracranial primitive neuroectodermal tumor 10.3 CHGA ENO2
20 multiple mucosal neuroma 10.3 ENO2 NCAM1
21 sinonasal undifferentiated carcinoma 10.3 ENO2 SYP
22 vulvar disease 10.3 CDKN2A TP53
23 vulva squamous cell carcinoma 10.3 CDKN2A TP53
24 scrotal carcinoma 10.3 CDKN2A TP53
25 lung meningioma 10.3 ENO2 NCAM1
26 nasal cavity adenocarcinoma 10.3 CDKN2A TP53
27 bartholin's gland disease 10.3 CDKN2A TP53
28 bladder carcinoma in situ 10.3 CDKN2A TP53
29 spitz nevus 10.3 CDKN2A TP53
30 adenoma of the pancreas 10.3 CHGA SYP
31 acinar cell cystadenocarcinoma 10.3 CHGA SYP
32 lung combined type small cell carcinoma 10.3 NCAM1 SYP
33 pancreatic somatostatinoma 10.2 ENO2 SYP
34 peritoneal serous adenocarcinoma 10.2 CHGA SYP
35 primary hepatic neuroendocrine carcinoma 10.2 CHGA SYP
36 urinary bladder small cell neuroendocrine carcinoma 10.2 CHGA ENO2 SYP
37 auditory system cancer 10.2 CHGA ENO2 SYP
38 papillary tumor of the pineal region 10.2 ENO2 SYP
39 small cell carcinoma of the bladder 10.2 CHGA ENO2 SYP
40 pulmonary large cell neuroendocrine carcinoma 10.2 CHGA ENO2 SYP
41 inappropriate adh syndrome 10.2 AVP POMC
42 cauda equina neoplasm 10.2 CHGA ENO2 SYP
43 microcystic meningioma 10.2 CDH17 ENO2
44 autonomic nervous system benign neoplasm 10.2 CHGA ENO2 SYP
45 nodular ganglioneuroblastoma 10.2 CHGA ENO2 SYP
46 choriocarcinoma of ovary 10.2 ENO2 NCAM1
47 pineocytoma 10.2 CHGA ENO2 SYP
48 ovarian serous adenofibroma 10.2 NCAM1 POMC
49 cutaneous ganglioneuroma 10.2 ENO2 NCAM1 SYP
50 extrahepatic bile duct adenocarcinoma 10.2 ENO2 NCAM1 SYP

Graphical network of the top 20 diseases related to Cervix Small Cell Carcinoma:



Diseases related to Cervix Small Cell Carcinoma

Symptoms & Phenotypes for Cervix Small Cell Carcinoma

MGI Mouse Phenotypes related to Cervix Small Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 AVP CDKN2A ENO2 MAPK8IP1 MAPK8IP2 NCAM1
2 growth/size/body region MP:0005378 9.96 CDH2 CDKN2A CHGA CXCR2 ENO2 MAPK8IP1
3 homeostasis/metabolism MP:0005376 9.9 AVP CDH2 CDKN2A CHGA CNN1 CXCR2
4 mortality/aging MP:0010768 9.73 AVP CDH2 CDKN2A CHGA CNN1 CXCR2
5 nervous system MP:0003631 9.44 AVP CDH2 CDKN2A CHGA CXCR2 ENO2

Drugs & Therapeutics for Cervix Small Cell Carcinoma

Drugs for Cervix Small Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2,Phase 1 15663-27-1 2767 441203 84093
2
Paclitaxel Approved, Vet_approved Phase 2,Phase 1 33069-62-4 36314
3
Topotecan Approved, Investigational Phase 2 123948-87-8, 119413-54-6 60700
4
Lenograstim Approved, Investigational Phase 2 135968-09-1
5
Cetuximab Approved Phase 2,Phase 1 205923-56-4 56842117 2333
6
Veliparib Investigational Phase 2 912444-00-9 11960529
7 Antibodies, Monoclonal Phase 2
8 Antibodies Phase 2
9 Immunoglobulins Phase 2
10 Immunologic Factors Phase 2,Phase 1
11 Antineoplastic Agents, Phytogenic Phase 2,Phase 1
12 Albumin-Bound Paclitaxel Phase 2,Phase 1
13 Antimitotic Agents Phase 2,Phase 1
14 Adjuvants, Immunologic Phase 2
15 Topoisomerase Inhibitors Phase 2
16 Poly(ADP-ribose) Polymerase Inhibitors Phase 2
17 topoisomerase I inhibitors Phase 2
18 Radiopharmaceuticals Phase 1, Phase 2
19 Fluorodeoxyglucose F18 Phase 1, Phase 2
20
Gemcitabine Approved Phase 1 95058-81-4 60750
21 Antiviral Agents Phase 1
22 Immunosuppressive Agents Phase 1
23 Antimetabolites, Antineoplastic Phase 1
24 Antimetabolites Phase 1
25 Anti-Infective Agents Phase 1
26
Formaldehyde Approved, Vet_approved 50-00-0 712
27 Krestin
28 Radiation-Protective Agents
29 Anti-Bacterial Agents
30 Antibiotics, Antitubercular
31 interferons
32 Protective Agents
33 Interferon Inducers

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Panitumumab, Cisplatin, and Pelvic Radiation Therapy in Treating Patients With Stage IB, Stage II, or Stage III Cervical Cancer Unknown status NCT01158248 Phase 2 cisplatin
2 ABI-007 in Treating Patients With Persistent or Recurrent Cervical Cancer Completed NCT00309959 Phase 2 Paclitaxel Albumin-Stabilized Nanoparticle Formulation
3 Pelvic Exenteration in Treating Patients With Recurrent Cervical Cancer Completed NCT00217633 Phase 2
4 Veliparib, Topotecan Hydrochloride, and Filgrastim or Pegfilgrastim in Treating Patients With Persistent or Recurrent Cervical Cancer Completed NCT01266447 Phase 2 Topotecan Hydrochloride;Veliparib
5 Fludeoxyglucose (FDG) F 18 PET Scan, CT Scan, and Ferumoxtran-10 MRI Scan Before Chemotherapy and Radiation Therapy in Finding Lymph Node Metastasis in Patients With Locally Advanced Cervical Cancer or High-Risk Endometrial Cancer Completed NCT00416455 Phase 1, Phase 2 ferumoxtran-10
6 Cetuximab and Cisplatin in Treating Patients With Advanced, Persistent, or Recurrent Cervical Cancer Completed NCT00101192 Phase 2 cisplatin
7 Paclitaxel, Topotecan, and Cisplatin in Treating Patients With Advanced, Persistent, or Recurrent Cervical Cancer Completed NCT00276796 Phase 2 cisplatin;paclitaxel;topotecan hydrochloride
8 Radiation Therapy Plus Paclitaxel and Cisplatin in Treating Patients With Cervical Cancer Completed NCT00003379 Phase 1, Phase 2 cisplatin;paclitaxel
9 ADXS11-001 High Dose HPV+ Cervical Cancer Active, not recruiting NCT02164461 Phase 1, Phase 2
10 Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer Completed NCT00104910 Phase 1 Cisplatin
11 Radiation Therapy Plus Cisplatin and Gemcitabine in Treating Patients With Cervical Cancer Completed NCT00068549 Phase 1 Gemcitabine Hydrochloride;Cisplatin
12 Glycoprotein and Glycan in Tissue and Blood Samples of Patients With Stage IB-IVA Cervical Cancer Undergoing Surgery to Remove Pelvic and Abdominal Lymph Nodes Completed NCT00460356
13 Collecting Tumor Samples From Patients With Gynecological Tumors Completed NCT00897442
14 Use of Social Networking to Survey Women With Small and Large Cell Carcinomas of the Cervix Recruiting NCT01606293

Search NIH Clinical Center for Cervix Small Cell Carcinoma

Genetic Tests for Cervix Small Cell Carcinoma

Anatomical Context for Cervix Small Cell Carcinoma

MalaCards organs/tissues related to Cervix Small Cell Carcinoma:

41
Cervix, Ovary, Lung, Tongue, Pancreas, Thyroid, Pineal

Publications for Cervix Small Cell Carcinoma

Articles related to Cervix Small Cell Carcinoma:

(show all 48)
# Title Authors Year
1
Advanced small cell carcinoma of the cervix - Successful treatment with concurrent etoposide and cisplatin chemotherapy and extended field radiation: A case report and discussion. ( 29255785 )
2018
2
Lambert-Eaton Myasthenic Syndrome Associated with Synchronous Double Cancer: A Combination of Small Cell Carcinoma of the Cervix and Breast Carcinoma. ( 29526952 )
2018
3
Influence of clinicopathological characteristics and comprehensive treatment models on the prognosis of small cell carcinoma of the cervix: A systematic review and meta-analysis. ( 29641578 )
2018
4
The local treatment modalities in FIGO stage I-II small-cell carcinoma of the cervix are determined by disease stage and lymph node status. ( 26990881 )
2016
5
Prognostic value of lymph node ratio in patients with small-cell carcinoma of the cervix based on data from a large national registry. ( 26730205 )
2016
6
Prognostic risk factors for small cell carcinoma of the cervix and impact of platinum-based neoadjuvant chemotherapy. ( 25890393 )
2015
7
Adenocarcinoma of the cervix associated with a neuroendocrine small cell carcinoma of the cervix in the spectrum of Muir-Torre syndrome. ( 26050364 )
2015
8
Metastatic small cell carcinoma of the cervix to the oral cavity: A rare case report and an insight into pathogenesis of metastasis. ( 26604504 )
2015
9
Gynecologic Cancer InterGroup (GCIG) Consensus Review for Small Cell Carcinoma of the Cervix. ( 25341572 )
2014
10
Radiation sensitivity assay with a panel of patient-derived spheroids of small cell carcinoma of the cervix. ( 25408479 )
2014
11
Metastatic small-cell carcinoma of the cervix during pregnancy. ( 24456456 )
2014
12
Small cell carcinoma of the cervix at 32-week gestation: a case report and review of the literature. ( 24719986 )
2014
13
Small cell carcinoma of the cervix in liquid-based Pap test: utilization of split-sample immunocytochemical and molecular analysis. ( 20891001 )
2012
14
Chromogranin A (CgA) as poor prognostic factor in patients with small cell carcinoma of the cervix: results of a retrospective study of 293 patients. ( 22529895 )
2012
15
Downregulation of six microRNAs is associated with advanced stage, lymph node metastasis and poor prognosis in small cell carcinoma of the cervix. ( 22438992 )
2012
16
Small cell carcinoma of the cervix: treatment and survival outcomes of 188 patients. ( 20579961 )
2010
17
Clinicopathological features and prognosis of small cell carcinoma of the cervix. ( 21063846 )
2010
18
Small-cell carcinoma of the cervix at 23 weeks gestation. ( 20385993 )
2010
19
Incidence, mortality, and prognostic factors of small cell carcinoma of the cervix. ( 18515524 )
2008
20
Small cell carcinoma of the cervix presenting with acute vaginal hemorrhage: a case report. ( 18455059 )
2008
21
Small cell carcinoma of the cervix: a case report. ( 17828547 )
2008
22
Neuroendocrine small cell carcinoma of the cervix associated with endocervical adenocarcinoma: a case report. ( 17718130 )
2007
23
Small-cell carcinoma of the cervix: fourteen years of experience at a single institution using a combined-modality regimen of involved-field irradiation and platinum-based combination chemotherapy. ( 12972526 )
2003
24
Small cell carcinoma of the cervix: a clinicopathologic and immunohistochemical study of 23 cases. ( 12478483 )
2002
25
Predictors of outcome in small cell carcinoma of the cervix--a case series. ( 11606074 )
2001
26
Small cell carcinoma of the cervix complicated by pregnancy. ( 10378639 )
1999
27
Hypoglycemia due to an insulin-secreting small-cell carcinoma of the cervix. ( 10471459 )
1999
28
Treatment resistant small cell carcinoma of the cervix. ( 10575314 )
1999
29
Small cell carcinoma of the cervix: analysis of clinical and pathological findings. ( 9611065 )
1998
30
Small cell carcinoma of the cervix: a clinical study of 15 patients and review of the literature. ( 10838295 )
1998
31
Small-Cell Carcinoma of the Cervix Presenting with Severe Hypokalemia as a Manifestation of Cushing's Syndrome. ( 25951213 )
1997
32
Efficacy of radical hysterectomy as treatment for patients with small cell carcinoma of the cervix. ( 8608533 )
1996
33
Small cell carcinoma of the cervix of neuroendocrine origin causing obstructed labour. ( 8775261 )
1996
34
Successful treatment of neuroendocrine small cell carcinoma of the cervix metastatic to regional lymph nodes. ( 8812543 )
1996
35
Small cell carcinoma of the cervix. ( 8859607 )
1996
36
Adjuvant chemotherapy in stage IB neuroendocrine small cell carcinoma of the cervix. ( 7572111 )
1995
37
Small cell carcinoma of the cervix treated with concurrent radiotherapy, cisplatin, and etoposide. ( 7896189 )
1995
38
Small cell carcinoma of the cervix. ( 11578477 )
1995
39
Small cell carcinoma of the cervix. A clinicopathologic study of 26 patients. ( 8299089 )
1994
40
Overexpression of p53 protein and c-erbB-2 protein in small cell carcinoma of the cervix uteri. ( 8103676 )
1993
41
Treatment of small cell carcinoma of the cervix with cisplatin, doxorubicin, and etoposide. ( 1330847 )
1992
42
Small cell carcinoma of the cervix: a clinical and flow-cytometric study. ( 1655594 )
1991
43
Adjuvant therapy for neuroendocrine small cell carcinoma of the cervix: review of the literature. ( 1660433 )
1991
44
Treatment of small-cell carcinoma of the cervix with weekly combination chemotherapy. ( 1697475 )
1990
45
Small cell carcinoma of the cervix with inappropriate antidiuretic hormone secretion. Case report. ( 2167728 )
1990
46
Simultaneous small cell carcinoma of the cervix and adenocarcinoma of the ovary. ( 2172123 )
1990
47
Eaton-Lambert syndrome as a harbinger of recurrent small-cell carcinoma of the cervix with improvement after combination chemotherapy. ( 2841632 )
1988
48
The pathologic spectrum of small cell carcinoma of the cervix. ( 2852175 )
1985

Variations for Cervix Small Cell Carcinoma

Cosmic variations for Cervix Small Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6932 TP53 cervix,NS,carcinoma,small cell carcinoma c.733G>A p.G245S 17:7674230-7674230 12
2 COSM145923 SF3B1 cervix,NS,carcinoma,small cell carcinoma c.2225G>A p.G742D 2:197401887-197401887 12
3 COSM6943414 RPS6KB2 cervix,NS,carcinoma,small cell carcinoma c.356A>C p.E119A 11:67431414-67431414 12
4 COSM6943412 RAD54L cervix,NS,carcinoma,small cell carcinoma c.388G>T p.D130Y 1:46260080-46260080 12
5 COSM763 PIK3CA cervix,NS,carcinoma,small cell carcinoma c.1633G>A p.E545K 3:179218303-179218303 12
6 COSM760 PIK3CA cervix,NS,carcinoma,small cell carcinoma c.1624G>A p.E542K 3:179218294-179218294 12
7 COSM3832368 KMT2C cervix,NS,carcinoma,small cell carcinoma c.4174C>T p.Q1392* 7:152199378-152199378 12
8 COSM125370 cervix,NS,carcinoma,small cell carcinoma c.1633G>A p.E545K 3:179218303-179218303 12
9 COSM6943413 cervix,NS,carcinoma,small cell carcinoma c.356A>C p.E119A 11:67431414-67431414 12
10 COSM3832367 cervix,NS,carcinoma,small cell carcinoma c.4174C>T p.Q1392* 7:152199378-152199378 12

Expression for Cervix Small Cell Carcinoma

Search GEO for disease gene expression data for Cervix Small Cell Carcinoma.

Pathways for Cervix Small Cell Carcinoma

Pathways related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.08 CDH17 CDH2 CDKN2A CXCL1 CXCR1 CXCR2
2 11.59 CDH17 CDH2 NCAM1
3 11.56 AVP ENO2 NCAM1 POMC SYP
4
Show member pathways
11.5 CXCL1 CXCR1 CXCR2
5 11.36 CDKN2A CXCL1 TP53

GO Terms for Cervix Small Cell Carcinoma

Cellular components related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 8.8 AVP CHGA POMC

Biological processes related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of JNK cascade GO:0046328 9.37 MAPK8IP1 MAPK8IP2
2 neutrophil chemotaxis GO:0030593 9.33 CXCL1 CXCR1 CXCR2
3 dendritic cell chemotaxis GO:0002407 9.32 CXCR1 CXCR2
4 replicative senescence GO:0090399 9.26 CDKN2A TP53
5 chemokine-mediated signaling pathway GO:0070098 9.13 CXCL1 CXCR1 CXCR2
6 interleukin-8-mediated signaling pathway GO:0038112 8.62 CXCR1 CXCR2

Molecular functions related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.55 CDH2 CDKN2A MAPK8IP1 MAPK8IP2 TP53
2 C-X-C chemokine receptor activity GO:0016494 9.32 CXCR1 CXCR2
3 MAP-kinase scaffold activity GO:0005078 9.26 MAPK8IP1 MAPK8IP2
4 interleukin-8 binding GO:0019959 8.96 CXCR1 CXCR2
5 interleukin-8 receptor activity GO:0004918 8.62 CXCR1 CXCR2

Sources for Cervix Small Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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