MCID: CRV022
MIFTS: 35

Cervix Small Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervix Small Cell Carcinoma

MalaCards integrated aliases for Cervix Small Cell Carcinoma:

Name: Cervix Small Cell Carcinoma 12 15
Small Cell Carcinoma of the Cervix 12 71
Small Cell Carcinoma of the Cervix Uteri 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6740
NCIt 49 C7982
UMLS 71 C0279674

Summaries for Cervix Small Cell Carcinoma

MalaCards based summary : Cervix Small Cell Carcinoma, also known as small cell carcinoma of the cervix, is related to small cell carcinoma and neuroendocrine carcinoma. An important gene associated with Cervix Small Cell Carcinoma is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are MicroRNAs in cancer and SRF and miRs in Smooth Muscle Differentiation and Proliferation. Affiliated tissues include cervix, lymph node and testes.

Related Diseases for Cervix Small Cell Carcinoma

Diseases related to Cervix Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 254)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma 30.9 SYP ENO2 CHGA
2 neuroendocrine carcinoma 30.5 SYP ENO2 CHGA
3 appendix adenocarcinoma 30.3 SYP CHGA
4 small cell cancer of the lung 30.3 SYP ENO2 CHGA
5 cervix carcinoma 30.3 MIR199A1 MAPK8IP2 MAPK8IP1
6 neuroendocrine tumor 30.0 SYP ENO2 CHGA
7 large cell neuroendocrine carcinoma 30.0 SYP ENO2 CHGA
8 lung oat cell carcinoma 30.0 SYP ENO2 CHGA
9 cervical carcinosarcoma 10.5 MAPK8IP2 MAPK8IP1
10 isthmus cancer 10.4 MAPK8IP2 MAPK8IP1
11 radiation cystitis 10.4 MAPK8IP2 MAPK8IP1
12 lymphocele 10.4 MAPK8IP2 MAPK8IP1
13 sigmoid disease 10.4 MAPK8IP2 MAPK8IP1
14 cervical adenosquamous carcinoma 10.4 MAPK8IP2 MAPK8IP1
15 malignant melanocytic neoplasm of the peripheral nerve sheath 10.4 SYP ENO2
16 vaginal cancer 10.4 MAPK8IP2 MAPK8IP1
17 anal neuroendocrine tumor 10.4 SYP ENO2
18 sinonasal undifferentiated carcinoma 10.4 SYP ENO2
19 cerebral neuroblastoma 10.4 SYP ENO2
20 papillary tumor of the pineal region 10.4 SYP ENO2
21 pineal region teratoma 10.3 SYP ENO2
22 intracranial primitive neuroectodermal tumor 10.3 SYP ENO2
23 bile duct mucinous adenocarcinoma 10.3 SYP ENO2
24 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.3 SYP ENO2
25 cerebellopontine angle primitive neuroectodermal tumor 10.3 SYP ENO2
26 nodular prostate 10.3 SYP ENO2
27 cerebellar liponeurocytoma 10.3 SYP ENO2
28 vaginal discharge 10.3 MAPK8IP2 MAPK8IP1
29 papillary ependymoma 10.3 SYP ENO2
30 jejunal neoplasm 10.3 SYP ENO2
31 vaginal glandular tumor 10.3 ENO2 CHGA
32 frontal lobe neoplasm 10.3 SYP ENO2
33 myoblastoma 10.3 SYP ENO2
34 pineal parenchymal tumor of intermediate differentiation 10.3 SYP ENO2
35 optic nerve astrocytoma 10.3 SYP ENO2
36 ureter transitional cell carcinoma 10.3 ENO2 CHGA
37 adrenal neuroblastoma 10.3 SYP ENO2
38 orbital cancer 10.3 SYP ENO2
39 goblet cell carcinoid 10.3 ENO2 CHGA
40 extraskeletal ewing sarcoma 10.3 SYP ENO2
41 gastric gastrinoma 10.3 ENO2 CHGA
42 endobronchial leiomyoma 10.3 SYP ENO2
43 nodular ganglioneuroblastoma 10.3 ENO2 CHGA
44 spinal cord oligodendroglioma 10.3 SYP ENO2
45 primary hepatic neuroendocrine carcinoma 10.3 SYP CHGA
46 nasal cavity olfactory neuroblastoma 10.3 SYP ENO2
47 ewing sarcoma of bone 10.3 ENO2 CHGA
48 acinar cell cystadenocarcinoma 10.3 SYP CHGA
49 vulvar eccrine porocarcinoma 10.3 SYP CHGA
50 cervical large cell neuroendocrine carcinoma 10.3 SYP CHGA

Graphical network of the top 20 diseases related to Cervix Small Cell Carcinoma:



Diseases related to Cervix Small Cell Carcinoma

Symptoms & Phenotypes for Cervix Small Cell Carcinoma

Drugs & Therapeutics for Cervix Small Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Cervix Small Cell Carcinoma

Genetic Tests for Cervix Small Cell Carcinoma

Anatomical Context for Cervix Small Cell Carcinoma

MalaCards organs/tissues related to Cervix Small Cell Carcinoma:

40
Cervix, Lymph Node, Testes, Bone, Breast, Ovary, Uterus

Publications for Cervix Small Cell Carcinoma

Articles related to Cervix Small Cell Carcinoma:

(show top 50) (show all 90)
# Title Authors PMID Year
1
Patterns of Care and Outcomes for Small Cell Carcinoma of the Cervix: A National Retrospective Analysis of 542 Cases. 61
32529135 2020
2
Cervix neuroendocrine carcinoma presenting with severe hypokalemia and Cushing's syndrome. 61
31970585 2020
3
Prognostic Factors and Local Treatment Modalities of Small-Cell Carcinoma of the Cervix: An Analysis According to the International Federation of Gynecology and Obstetrics Stage. 61
32523375 2020
4
Postoperative adjuvant radiation improves local control in surgically treated FIGO stage I-II small cell carcinoma of the cervix. 61
31722727 2019
5
Rare Hereditary Burden associated with a Hypercalcemic Small-Cell Carcinoma of Cervix in a Young Female Patient. 61
31842565 2019
6
Lambert-Eaton Myasthenic Syndrome Associated with Synchronous Double Cancer: A Combination of Small Cell Carcinoma of the Cervix and Breast Carcinoma. 61
29526952 2018
7
Advanced small cell carcinoma of the cervix - Successful treatment with concurrent etoposide and cisplatin chemotherapy and extended field radiation: A case report and discussion. 61
29255785 2018
8
Influence of clinicopathological characteristics and comprehensive treatment models on the prognosis of small cell carcinoma of the cervix: A systematic review and meta-analysis. 61
29641578 2018
9
Clinicopathological features of small cell carcinoma of the uterine cervix in the surveillance, epidemiology, and end results database. 61
28415576 2017
10
Early Detection of Bone Metastasis in Small Cell Neuroendocrine Carcinoma of the Cervix by 68Ga-DOTATATE PET/CT Imaging. 61
28005640 2017
11
The local treatment modalities in FIGO stage I-II small-cell carcinoma of the cervix are determined by disease stage and lymph node status. 61
26990881 2016
12
Prognostic value of lymph node ratio in patients with small-cell carcinoma of the cervix based on data from a large national registry. 61
26730205 2016
13
Prognostic risk factors for small cell carcinoma of the cervix and impact of platinum-based neoadjuvant chemotherapy. 61
25890393 2015
14
Radiation sensitivity assay with a panel of patient-derived spheroids of small cell carcinoma of the cervix. 61
25408479 2015
15
Metastatic small cell carcinoma of the cervix to the oral cavity: A rare case report and an insight into pathogenesis of metastasis. 61
26604504 2015
16
Adenocarcinoma of the cervix associated with a neuroendocrine small cell carcinoma of the cervix in the spectrum of Muir-Torre syndrome. 61
26050364 2015
17
Gynecologic Cancer InterGroup (GCIG) consensus review for small cell carcinoma of the cervix. 61
25341572 2014
18
Metastatic small-cell carcinoma of the cervix during pregnancy. 61
24456456 2014
19
Small cell neuroendocrine carcinoma of the cervix: a rare entity. 61
24701511 2014
20
Small cell carcinoma of the uterine cervix in a pregnant patient diagnosed with liquid based cytology and cell block immunocytochemistry. 61
25254132 2014
21
Small cell carcinoma of the cervix at 32-week gestation: a case report and review of the literature. 61
24719986 2014
22
Small cell neuroendocrine carcinoma of the uterine cervix presenting with syndrome of inappropriate antidiuretic hormone secretion. 61
24396824 2013
23
The management of small-cell carcinomas of the gynecologic tract. 61
22820410 2012
24
Small cell carcinoma of the cervix in liquid-based Pap test: utilization of split-sample immunocytochemical and molecular analysis. 61
20891001 2012
25
Downregulation of six microRNAs is associated with advanced stage, lymph node metastasis and poor prognosis in small cell carcinoma of the cervix. 61
22438992 2012
26
Chromogranin A (CgA) as poor prognostic factor in patients with small cell carcinoma of the cervix: results of a retrospective study of 293 patients. 61
22529895 2012
27
p16(INK4a) and ProEx C immunostains facilitate differential diagnosis of hyperchromatic crowded groups in liquid-based Papanicolaou tests with menstrual contamination. 61
22236746 2012
28
A clinicopathological aspect of primary small-cell carcinoma of the uterine cervix: a single-centre study of 25 cases. 61
21965825 2011
29
Clinicopathological features and prognosis of small cell carcinoma of the cervix. 61
21063846 2010
30
Small cell carcinoma of the cervix: treatment and survival outcomes of 188 patients. 61
20579961 2010
31
Small-cell carcinoma of the cervix at 23 weeks gestation. 61
20385993 2010
32
Small cell cervical cancer: an unusual finding at cholecystectomy. 61
18548263 2009
33
[Cervix small cell carcinoma: report of a case]. 61
19035126 2008
34
Incidence, mortality, and prognostic factors of small cell carcinoma of the cervix. 61
18515524 2008
35
Small cell carcinoma of the cervix presenting with acute vaginal hemorrhage: a case report. 61
18455059 2008
36
Small cell carcinoma of the cervix: a case report. 61
17828547 2008
37
[Clinicopathologic characteristics of eight patients with small cell carcinoma of the cervix]. 61
18788567 2008
38
Neuroendocrine small cell carcinoma of the cervix associated with endocervical adenocarcinoma: a case report. 61
17718130 2007
39
Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer. 61
16865269 2006
40
Small cell neuroendocrine carcinoma of the cervix: outcome and patterns of recurrence. 61
15047210 2004
41
Small-cell carcinoma of the cervix: fourteen years of experience at a single institution using a combined-modality regimen of involved-field irradiation and platinum-based combination chemotherapy. 61
12972526 2003
42
P16 overexpression and human papillomavirus infection in small cell carcinoma of the uterine cervix. 61
14506638 2003
43
Expression of cadherins, p53, and BCL2 in small cell carcinomas of the cervix: potential tumor suppressor role for N-cadherin. 61
12657131 2003
44
Prognostic factors in neuroendocrine small cell cervical carcinoma: a multivariate analysis. 61
12548598 2003
45
Thin-layer cytology findings of small cell carcinoma of the lower female genital tract. Review of three cases with molecular analysis. 61
12585032 2003
46
Small cell carcinoma of the cervix: a clinicopathologic and immunohistochemical study of 23 cases. 61
12478483 2002
47
Neuroendocrine marker expression in cervical carcinomas of non-small cell type. 61
12352185 2002
48
Predictors of outcome in small cell carcinoma of the cervix--a case series. 61
11606074 2001
49
Establishment and characterization of a new cell line (SKS) from neuroendocrine small cell carcinoma of the uterine cervix and its chemosensitivity. 61
11408806 2001
50
Neuroendocrine tumors of the uterine cervix. Clinicopathologic study of five patients. 61
10817879 2000

Variations for Cervix Small Cell Carcinoma

Cosmic variations for Cervix Small Cell Carcinoma:

9 (show top 50) (show all 114)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM87908196 TP53 cervix,NS,carcinoma,small cell carcinoma c.714T>G p.C238W 17:7674249-7674249 12
2 COSM87901020 TP53 cervix,NS,carcinoma,small cell carcinoma c.811G>C p.E271Q 17:7673809-7673809 12
3 COSM87898578 TP53 cervix,NS,carcinoma,small cell carcinoma c.733G>A p.G245S 17:7674230-7674230 12
4 COSM87898605 TP53 cervix,NS,carcinoma,small cell carcinoma c.824G>A p.C275Y 17:7673796-7673796 12
5 COSM89612441 SF3B1 cervix,NS,carcinoma,small cell carcinoma c.2225G>A p.G742D 2:197401887-197401887 12
6 COSM88562363 RPS6KB2 cervix,NS,carcinoma,small cell carcinoma c.356A>C p.E119A 11:67431414-67431414 12
7 COSM96919946 RAD54L cervix,NS,carcinoma,small cell carcinoma c.388G>T p.D130Y 1:46260080-46260080 12
8 COSM96842401 PTEN cervix,NS,carcinoma,small cell carcinoma c.395G>A p.G132D 10:87933154-87933154 12
9 COSM96851201 PTEN cervix,NS,carcinoma,small cell carcinoma c.722T>C p.F241S 10:87957940-87957940 12
10 COSM87143793 PIK3CA cervix,NS,carcinoma,small cell carcinoma c.317G>C p.G106A 3:179199142-179199142 12
11 COSM87132847 PIK3CA cervix,NS,carcinoma,small cell carcinoma c.1635G>T p.E545D 3:179218305-179218305 12
12 COSM87132308 PIK3CA cervix,NS,carcinoma,small cell carcinoma c.1633G>A p.E545K 3:179218303-179218303 12
13 COSM87152383 PIK3CA cervix,NS,carcinoma,small cell carcinoma c.1034A>C p.N345T 3:179203764-179203764 12
14 COSM87132301 PIK3CA cervix,NS,carcinoma,small cell carcinoma c.1624G>A p.E542K 3:179218294-179218294 12
15 COSM87647442 NOTCH1 cervix,NS,carcinoma,small cell carcinoma c.6943C>T p.Q2315* 9:136496796-136496796 12
16 COSM142626395 MYC cervix,NS,carcinoma,small cell carcinoma c.595G>A p.A199T 8:127738812-127738812 12
17 COSM87804055 KRAS cervix,NS,carcinoma,small cell carcinoma c.35G>T p.G12V 12:25245350-25245350 12
18 COSM88402634 KMT2C cervix,NS,carcinoma,small cell carcinoma c.4174C>T p.Q1392* 7:152199378-152199378 12
19 COSM88586532 ERBB2 cervix,NS,carcinoma,small cell carcinoma c.2033G>A p.R678Q 17:39723405-39723405 12
20 COSM103979650 BCL6 cervix,NS,carcinoma,small cell carcinoma c.1125G>T p.W375C 3:187729280-187729280 12
21 COSM143944022 cervix,NS,carcinoma,small cell carcinoma c.347G>A p.C116Y 17:7673796-7673796 12
22 COSM144088917 cervix,NS,carcinoma,small cell carcinoma c.334G>C p.E112Q 17:7673809-7673809 12
23 COSM144317223 cervix,NS,carcinoma,small cell carcinoma c.597T>G p.C199W 17:7674249-7674249 12
24 COSM102893122 cervix,NS,carcinoma,small cell carcinoma c.1943G>A p.R648Q 17:39723405-39723405 12
25 COSM144310384 cervix,NS,carcinoma,small cell carcinoma c.707G>A p.C236Y 17:7673796-7673796 12
26 COSM128570663 cervix,NS,carcinoma,small cell carcinoma c.592G>A p.A198T 8:127738812-127738812 12
27 COSM148932717 cervix,NS,carcinoma,small cell carcinoma c.1624G>A p.E542K 3:179218294-179218294 12
28 COSM142837497 cervix,NS,carcinoma,small cell carcinoma c.733G>A p.G245S 17:7674230-7674230 12
29 COSM144013587 cervix,NS,carcinoma,small cell carcinoma c.700G>A p.G234S 17:7674230-7674230 12
30 COSM110284066 cervix,NS,carcinoma,small cell carcinoma c.388G>T p.D130Y 1:46260080-46260080 12
31 COSM143158932 cervix,NS,carcinoma,small cell carcinoma c.334G>C p.E112Q 17:7673809-7673809 12
32 COSM145728708 cervix,NS,carcinoma,small cell carcinoma c.1125G>T p.W375C 3:187729280-187729280 12
33 COSM93186154 cervix,NS,carcinoma,small cell carcinoma c.811G>C p.E271Q 17:7673809-7673809 12
34 COSM113677044 cervix,NS,carcinoma,small cell carcinoma c.1125G>T p.W375C 3:187729280-187729280 12
35 COSM122271749 cervix,NS,carcinoma,small cell carcinoma c.337G>A p.G113S 17:7674230-7674230 12
36 COSM111758803 cervix,NS,carcinoma,small cell carcinoma c.824G>A p.C275Y 17:7673796-7673796 12
37 COSM93183907 cervix,NS,carcinoma,small cell carcinoma c.824G>A p.C275Y 17:7673796-7673796 12
38 COSM144310364 cervix,NS,carcinoma,small cell carcinoma c.616G>A p.G206S 17:7674230-7674230 12
39 COSM142837517 cervix,NS,carcinoma,small cell carcinoma c.824G>A p.C275Y 17:7673796-7673796 12
40 COSM144651337 cervix,NS,carcinoma,small cell carcinoma c.616G>A p.G206S 17:7674230-7674230 12
41 COSM91859752 cervix,NS,carcinoma,small cell carcinoma c.35G>T p.G12V 12:25245350-25245350 12
42 COSM142839064 cervix,NS,carcinoma,small cell carcinoma c.811G>C p.E271Q 17:7673809-7673809 12
43 COSM112261636 cervix,NS,carcinoma,small cell carcinoma c.714T>G p.C238W 17:7674249-7674249 12
44 COSM143371097 cervix,NS,carcinoma,small cell carcinoma c.707G>A p.C236Y 17:7673796-7673796 12
45 COSM121886439 cervix,NS,carcinoma,small cell carcinoma c.318T>G p.C106W 17:7674249-7674249 12
46 COSM144093373 cervix,NS,carcinoma,small cell carcinoma c.237T>G p.C79W 17:7674249-7674249 12
47 COSM102191379 cervix,NS,carcinoma,small cell carcinoma c.550G>A p.A184T 8:127738812-127738812 12
48 COSM122734335 cervix,NS,carcinoma,small cell carcinoma c.337G>A p.G113S 17:7674230-7674230 12
49 COSM143156960 cervix,NS,carcinoma,small cell carcinoma c.256G>A p.G86S 17:7674230-7674230 12
50 COSM140440884 cervix,NS,carcinoma,small cell carcinoma c.1943G>A p.R648Q 17:39723405-39723405 12

Expression for Cervix Small Cell Carcinoma

Search GEO for disease gene expression data for Cervix Small Cell Carcinoma.

Pathways for Cervix Small Cell Carcinoma

Pathways related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.51 MIRLET7C MIR199A1 MIR145 MIR143 MIR100
2 10.07 MIR199A1 MIR145

GO Terms for Cervix Small Cell Carcinoma

Cellular components related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 MIRLET7C MIR199A1 MIR143 MIR100 ENO2 DDR1

Biological processes related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gene silencing by miRNA GO:0035195 9.65 MIRLET7C MIR199A1 MIR145 MIR143 MIR100
2 negative regulation of smooth muscle cell proliferation GO:0048662 9.48 MIR145 MIR143
3 positive regulation of endocytosis GO:0045807 9.46 MAPK8IP2 MAPK8IP1
4 regulation of JNK cascade GO:0046328 9.43 MAPK8IP2 MAPK8IP1
5 negative regulation of interleukin-8 secretion GO:2000483 9.4 MIRLET7C MIR100
6 regulation of smooth muscle contraction GO:0006940 9.37 MIR145 MIR143
7 angiotensin-activated signaling pathway GO:0038166 9.32 MIR145 MIR143
8 aorta smooth muscle tissue morphogenesis GO:0060414 9.16 MIR145 MIR143
9 regulation of phenotypic switching GO:1900239 8.96 MIR145 MIR143
10 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 8.62 MIR145 MIR143

Molecular functions related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.02 MIRLET7C MIR199A1 MIR145 MIR143 MIR100
2 MAP-kinase scaffold activity GO:0005078 8.96 MAPK8IP2 MAPK8IP1

Sources for Cervix Small Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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