MCID: CRV022
MIFTS: 34

Cervix Small Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervix Small Cell Carcinoma

MalaCards integrated aliases for Cervix Small Cell Carcinoma:

Name: Cervix Small Cell Carcinoma 12 15
Small Cell Carcinoma of the Cervix 12 70
Small Cell Carcinoma of the Cervix Uteri 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6740
NCIt 50 C7982
UMLS 70 C0279674

Summaries for Cervix Small Cell Carcinoma

MalaCards based summary : Cervix Small Cell Carcinoma, also known as small cell carcinoma of the cervix, is related to neuroendocrine carcinoma and neuroendocrine tumor. An important gene associated with Cervix Small Cell Carcinoma is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are MicroRNAs in cancer and SRF and miRs in Smooth Muscle Differentiation and Proliferation. Affiliated tissues include cervix, lymph node and ovary.

Related Diseases for Cervix Small Cell Carcinoma

Diseases related to Cervix Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 258)
# Related Disease Score Top Affiliating Genes
1 neuroendocrine carcinoma 30.9 SYP ENO2 CHGA
2 neuroendocrine tumor 30.4 SYP ENO2 CHGA
3 large cell neuroendocrine carcinoma 30.3 SYP ENO2 CHGA
4 merkel cell carcinoma 30.3 SYP ENO2 CHGA
5 small cell carcinoma 30.2 SYP ENO2 CHGA
6 lung cancer 28.2 SYP MIRLET7C MIR199A1 MIR145 MIR143 MIR125B1
7 malignant melanocytic neoplasm of the peripheral nerve sheath 10.3 SYP ENO2
8 anal neuroendocrine tumor 10.3 SYP ENO2
9 suppressor of tumorigenicity 3 10.3
10 optic nerve astrocytoma 10.3 SYP ENO2
11 cerebral neuroblastoma 10.3 SYP ENO2
12 neuronal intestinal dysplasia, type b 10.3 SYP ENO2
13 lung meningioma 10.3 SYP ENO2
14 sinonasal undifferentiated carcinoma 10.3 SYP ENO2
15 papillary tumor of the pineal region 10.3 SYP ENO2
16 cloacogenic carcinoma 10.3 SYP ENO2
17 pineal region teratoma 10.3 SYP ENO2
18 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.3 SYP ENO2
19 intracranial primitive neuroectodermal tumor 10.3 SYP ENO2
20 bile duct mucinous adenocarcinoma 10.3 SYP ENO2
21 nodular prostate 10.3 SYP ENO2
22 vaginal glandular tumor 10.3 ENO2 CHGA
23 cerebellar liponeurocytoma 10.3 SYP ENO2
24 ureter transitional cell carcinoma 10.3 ENO2 CHGA
25 cerebellopontine angle primitive neuroectodermal tumor 10.3 SYP ENO2
26 jejunal neoplasm 10.3 SYP ENO2
27 frontal lobe neoplasm 10.3 SYP ENO2
28 gastric gastrinoma 10.3 ENO2 CHGA
29 myoblastoma 10.3 SYP ENO2
30 pineal parenchymal tumor of intermediate differentiation 10.3 SYP ENO2
31 primary hepatic neuroendocrine carcinoma 10.3 SYP CHGA
32 esophageal neuroendocrine tumor 10.3 SYP CHGA
33 nodular ganglioneuroblastoma 10.3 ENO2 CHGA
34 kidney rhabdoid cancer 10.3 SYP ENO2
35 spinal cord oligodendroglioma 10.3 SYP ENO2
36 endobronchial leiomyoma 10.3 SYP ENO2
37 acinar cell cystadenocarcinoma 10.3 SYP CHGA
38 orbital cancer 10.3 SYP ENO2
39 goblet cell carcinoid 10.3 ENO2 CHGA
40 vulvar eccrine porocarcinoma 10.3 SYP CHGA
41 ewing sarcoma of bone 10.3 ENO2 CHGA
42 pancreatic serous cystadenocarcinoma 10.3 SYP CHGA
43 gastrointestinal neuroendocrine benign tumor 10.3 SYP CHGA
44 extraosseous ewing sarcoma 10.3 SYP ENO2
45 small cell osteogenic sarcoma 10.3 SYP ENO2
46 endobronchial lipoma 10.3 SYP ENO2
47 vaginal tubulovillous adenoma 10.3 SYP CHGA
48 appendix lymphoma 10.3 ENO2 CHGA
49 mixed ductal-endocrine carcinoma 10.3 SYP CHGA
50 laryngeal small cell carcinoma 10.3 SYP CHGA

Graphical network of the top 20 diseases related to Cervix Small Cell Carcinoma:



Diseases related to Cervix Small Cell Carcinoma

Symptoms & Phenotypes for Cervix Small Cell Carcinoma

Drugs & Therapeutics for Cervix Small Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Cervix Small Cell Carcinoma

Genetic Tests for Cervix Small Cell Carcinoma

Anatomical Context for Cervix Small Cell Carcinoma

MalaCards organs/tissues related to Cervix Small Cell Carcinoma:

40
Cervix, Lymph Node, Ovary, Uterus

Publications for Cervix Small Cell Carcinoma

Articles related to Cervix Small Cell Carcinoma:

(show top 50) (show all 95)
# Title Authors PMID Year
1
Neuroendocrine small cell carcinoma of the cervix: A case report. 61
33767861 2021
2
Optimal treatment strategies for small cell carcinoma of the uterine cervix: A retrospective multi-center study (KROG 19-03). 61
33545454 2021
3
Small cell carcinoma of the cervix complicated by syndrome of inappropriate antidiuretic hormone secretion: a case report. 61
33596689 2021
4
Trends and predictors of survival for small cell carcinoma of the cervix uteri: A SEER population study. 61
32768799 2020
5
Patterns of Care and Outcomes for Small Cell Carcinoma of the Cervix: A National Retrospective Analysis of 542 Cases. 61
32529135 2020
6
Cervix neuroendocrine carcinoma presenting with severe hypokalemia and Cushing's syndrome. 61
31970585 2020
7
Prognostic Factors and Local Treatment Modalities of Small-Cell Carcinoma of the Cervix: An Analysis According to the International Federation of Gynecology and Obstetrics Stage. 61
32523375 2020
8
Erratum: Prognostic Factors and Local Treatment Modalities of Small-Cell Carcinoma of the Cervix: An Analysis According to the International Federation of Gynecology and Obstetrics Stage [Corrigendum]. 61
32884338 2020
9
Postoperative adjuvant radiation improves local control in surgically treated FIGO stage I-II small cell carcinoma of the cervix. 61
31722727 2019
10
Rare Hereditary Burden associated with a Hypercalcemic Small-Cell Carcinoma of Cervix in a Young Female Patient. 61
31842565 2019
11
Lambert-Eaton Myasthenic Syndrome Associated with Synchronous Double Cancer: A Combination of Small Cell Carcinoma of the Cervix and Breast Carcinoma. 61
29526952 2018
12
Advanced small cell carcinoma of the cervix - Successful treatment with concurrent etoposide and cisplatin chemotherapy and extended field radiation: A case report and discussion. 61
29255785 2018
13
Influence of clinicopathological characteristics and comprehensive treatment models on the prognosis of small cell carcinoma of the cervix: A systematic review and meta-analysis. 61
29641578 2018
14
Clinicopathological features of small cell carcinoma of the uterine cervix in the surveillance, epidemiology, and end results database. 61
28415576 2017
15
Early Detection of Bone Metastasis in Small Cell Neuroendocrine Carcinoma of the Cervix by 68Ga-DOTATATE PET/CT Imaging. 61
28005640 2017
16
The local treatment modalities in FIGO stage I-II small-cell carcinoma of the cervix are determined by disease stage and lymph node status. 61
26990881 2016
17
Prognostic value of lymph node ratio in patients with small-cell carcinoma of the cervix based on data from a large national registry. 61
26730205 2016
18
Prognostic risk factors for small cell carcinoma of the cervix and impact of platinum-based neoadjuvant chemotherapy. 61
25890393 2015
19
Radiation sensitivity assay with a panel of patient-derived spheroids of small cell carcinoma of the cervix. 61
25408479 2015
20
Metastatic small cell carcinoma of the cervix to the oral cavity: A rare case report and an insight into pathogenesis of metastasis. 61
26604504 2015
21
Adenocarcinoma of the cervix associated with a neuroendocrine small cell carcinoma of the cervix in the spectrum of Muir-Torre syndrome. 61
26050364 2015
22
Gynecologic Cancer InterGroup (GCIG) consensus review for small cell carcinoma of the cervix. 61
25341572 2014
23
Metastatic small-cell carcinoma of the cervix during pregnancy. 61
24456456 2014
24
Small cell neuroendocrine carcinoma of the cervix: a rare entity. 61
24701511 2014
25
Small cell carcinoma of the cervix at 32-week gestation: a case report and review of the literature. 61
24719986 2014
26
Small cell carcinoma of the uterine cervix in a pregnant patient diagnosed with liquid based cytology and cell block immunocytochemistry. 61
25254132 2014
27
Small cell neuroendocrine carcinoma of the uterine cervix presenting with syndrome of inappropriate antidiuretic hormone secretion. 61
24396824 2013
28
The management of small-cell carcinomas of the gynecologic tract. 61
22820410 2012
29
Small cell carcinoma of the cervix in liquid-based Pap test: utilization of split-sample immunocytochemical and molecular analysis. 61
20891001 2012
30
Downregulation of six microRNAs is associated with advanced stage, lymph node metastasis and poor prognosis in small cell carcinoma of the cervix. 61
22438992 2012
31
Chromogranin A (CgA) as poor prognostic factor in patients with small cell carcinoma of the cervix: results of a retrospective study of 293 patients. 61
22529895 2012
32
p16(INK4a) and ProEx C immunostains facilitate differential diagnosis of hyperchromatic crowded groups in liquid-based Papanicolaou tests with menstrual contamination. 61
22236746 2012
33
A clinicopathological aspect of primary small-cell carcinoma of the uterine cervix: a single-centre study of 25 cases. 61
21965825 2011
34
Clinicopathological features and prognosis of small cell carcinoma of the cervix. 61
21063846 2010
35
Small cell carcinoma of the cervix: treatment and survival outcomes of 188 patients. 61
20579961 2010
36
Small-cell carcinoma of the cervix at 23 weeks gestation. 61
20385993 2010
37
Small cell cervical cancer: an unusual finding at cholecystectomy. 61
18548263 2009
38
[Cervix small cell carcinoma: report of a case]. 61
19035126 2008
39
Incidence, mortality, and prognostic factors of small cell carcinoma of the cervix. 61
18515524 2008
40
Small cell carcinoma of the cervix presenting with acute vaginal hemorrhage: a case report. 61
18455059 2008
41
Small cell carcinoma of the cervix: a case report. 61
17828547 2008
42
[Clinicopathologic characteristics of eight patients with small cell carcinoma of the cervix]. 61
18788567 2008
43
Neuroendocrine small cell carcinoma of the cervix associated with endocervical adenocarcinoma: a case report. 61
17718130 2007
44
Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer. 61
16865269 2006
45
Small cell neuroendocrine carcinoma of the cervix: outcome and patterns of recurrence. 61
15047210 2004
46
Small-cell carcinoma of the cervix: fourteen years of experience at a single institution using a combined-modality regimen of involved-field irradiation and platinum-based combination chemotherapy. 61
12972526 2003
47
P16 overexpression and human papillomavirus infection in small cell carcinoma of the uterine cervix. 61
14506638 2003
48
Expression of cadherins, p53, and BCL2 in small cell carcinomas of the cervix: potential tumor suppressor role for N-cadherin. 61
12657131 2003
49
Prognostic factors in neuroendocrine small cell cervical carcinoma: a multivariate analysis. 61
12548598 2003
50
Thin-layer cytology findings of small cell carcinoma of the lower female genital tract. Review of three cases with molecular analysis. 61
12585032 2003

Variations for Cervix Small Cell Carcinoma

Cosmic variations for Cervix Small Cell Carcinoma:

9 (show top 50) (show all 114)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM143944022 TP53 cervix,NS,carcinoma,small cell carcinoma c.347G>A p.C116Y 17:7673796-7673796 9
2 COSM144088917 TP53 cervix,NS,carcinoma,small cell carcinoma c.334G>C p.E112Q 17:7673809-7673809 9
3 COSM144317223 TP53 cervix,NS,carcinoma,small cell carcinoma c.597T>G p.C199W 17:7674249-7674249 9
4 COSM144310384 TP53 cervix,NS,carcinoma,small cell carcinoma c.707G>A p.C236Y 17:7673796-7673796 9
5 COSM142837497 TP53 cervix,NS,carcinoma,small cell carcinoma c.733G>A p.G245S 17:7674230-7674230 9
6 COSM144013587 TP53 cervix,NS,carcinoma,small cell carcinoma c.700G>A p.G234S 17:7674230-7674230 9
7 COSM143158932 TP53 cervix,NS,carcinoma,small cell carcinoma c.334G>C p.E112Q 17:7673809-7673809 9
8 COSM93186154 TP53 cervix,NS,carcinoma,small cell carcinoma c.811G>C p.E271Q 17:7673809-7673809 9
9 COSM122271749 TP53 cervix,NS,carcinoma,small cell carcinoma c.337G>A p.G113S 17:7674230-7674230 9
10 COSM111758803 TP53 cervix,NS,carcinoma,small cell carcinoma c.824G>A p.C275Y 17:7673796-7673796 9
11 COSM93183907 TP53 cervix,NS,carcinoma,small cell carcinoma c.824G>A p.C275Y 17:7673796-7673796 9
12 COSM144310364 TP53 cervix,NS,carcinoma,small cell carcinoma c.616G>A p.G206S 17:7674230-7674230 9
13 COSM142837517 TP53 cervix,NS,carcinoma,small cell carcinoma c.824G>A p.C275Y 17:7673796-7673796 9
14 COSM144651337 TP53 cervix,NS,carcinoma,small cell carcinoma c.616G>A p.G206S 17:7674230-7674230 9
15 COSM142839064 TP53 cervix,NS,carcinoma,small cell carcinoma c.811G>C p.E271Q 17:7673809-7673809 9
16 COSM112261636 TP53 cervix,NS,carcinoma,small cell carcinoma c.714T>G p.C238W 17:7674249-7674249 9
17 COSM143371097 TP53 cervix,NS,carcinoma,small cell carcinoma c.707G>A p.C236Y 17:7673796-7673796 9
18 COSM121886439 TP53 cervix,NS,carcinoma,small cell carcinoma c.318T>G p.C106W 17:7674249-7674249 9
19 COSM144093373 TP53 cervix,NS,carcinoma,small cell carcinoma c.237T>G p.C79W 17:7674249-7674249 9
20 COSM122734335 TP53 cervix,NS,carcinoma,small cell carcinoma c.337G>A p.G113S 17:7674230-7674230 9
21 COSM143156960 TP53 cervix,NS,carcinoma,small cell carcinoma c.256G>A p.G86S 17:7674230-7674230 9
22 COSM105620519 TP53 cervix,NS,carcinoma,small cell carcinoma c.733G>A p.G245S 17:7674230-7674230 9
23 COSM106061693 TP53 cervix,NS,carcinoma,small cell carcinoma c.714T>G p.C238W 17:7674249-7674249 9
24 COSM144312263 TP53 cervix,NS,carcinoma,small cell carcinoma c.694G>C p.E232Q 17:7673809-7673809 9
25 COSM143373342 TP53 cervix,NS,carcinoma,small cell carcinoma c.694G>C p.E232Q 17:7673809-7673809 9
26 COSM144654072 TP53 cervix,NS,carcinoma,small cell carcinoma c.694G>C p.E232Q 17:7673809-7673809 9
27 COSM105629290 TP53 cervix,NS,carcinoma,small cell carcinoma c.714T>G p.C238W 17:7674249-7674249 9
28 COSM122271777 TP53 cervix,NS,carcinoma,small cell carcinoma c.428G>A p.C143Y 17:7673796-7673796 9
29 COSM142560506 TP53 cervix,NS,carcinoma,small cell carcinoma c.707G>A p.C236Y 17:7673796-7673796 9
30 COSM111758775 TP53 cervix,NS,carcinoma,small cell carcinoma c.733G>A p.G245S 17:7674230-7674230 9
31 COSM144087244 TP53 cervix,NS,carcinoma,small cell carcinoma c.347G>A p.C116Y 17:7673796-7673796 9
32 COSM122736338 TP53 cervix,NS,carcinoma,small cell carcinoma c.415G>C p.E139Q 17:7673809-7673809 9
33 COSM111767926 TP53 cervix,NS,carcinoma,small cell carcinoma c.714T>G p.C238W 17:7674249-7674249 9
34 COSM144021901 TP53 cervix,NS,carcinoma,small cell carcinoma c.681T>G p.C227W 17:7674249-7674249 9
35 COSM142843633 TP53 cervix,NS,carcinoma,small cell carcinoma c.714T>G p.C238W 17:7674249-7674249 9
36 COSM143164074 TP53 cervix,NS,carcinoma,small cell carcinoma c.237T>G p.C79W 17:7674249-7674249 9
37 COSM87908196 TP53 cervix,NS,carcinoma,small cell carcinoma c.714T>G p.C238W 17:7674249-7674249 9
38 COSM93183877 TP53 cervix,NS,carcinoma,small cell carcinoma c.733G>A p.G245S 17:7674230-7674230 9
39 COSM145020497 TP53 cervix,NS,carcinoma,small cell carcinoma c.694G>C p.E232Q 17:7673809-7673809 9
40 COSM142568610 TP53 cervix,NS,carcinoma,small cell carcinoma c.597T>G p.C199W 17:7674249-7674249 9
41 COSM144660811 TP53 cervix,NS,carcinoma,small cell carcinoma c.597T>G p.C199W 17:7674249-7674249 9
42 COSM144015679 TP53 cervix,NS,carcinoma,small cell carcinoma c.778G>C p.E260Q 17:7673809-7673809 9
43 COSM145017887 TP53 cervix,NS,carcinoma,small cell carcinoma c.707G>A p.C236Y 17:7673796-7673796 9
44 COSM106053386 TP53 cervix,NS,carcinoma,small cell carcinoma c.824G>A p.C275Y 17:7673796-7673796 9
45 COSM106055520 TP53 cervix,NS,carcinoma,small cell carcinoma c.811G>C p.E271Q 17:7673809-7673809 9
46 COSM143371076 TP53 cervix,NS,carcinoma,small cell carcinoma c.616G>A p.G206S 17:7674230-7674230 9
47 COSM142560476 TP53 cervix,NS,carcinoma,small cell carcinoma c.616G>A p.G206S 17:7674230-7674230 9
48 COSM105622908 TP53 cervix,NS,carcinoma,small cell carcinoma c.782+372G>C p.? 17:7673809-7673809 9
49 COSM112255642 TP53 cervix,NS,carcinoma,small cell carcinoma c.811G>C p.E271Q 17:7673809-7673809 9
50 COSM143943997 TP53 cervix,NS,carcinoma,small cell carcinoma c.256G>A p.G86S 17:7674230-7674230 9

Expression for Cervix Small Cell Carcinoma

Search GEO for disease gene expression data for Cervix Small Cell Carcinoma.

Pathways for Cervix Small Cell Carcinoma

Pathways related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.66 MIRLET7C MIR199A1 MIR145 MIR143 MIR125B1 MIR10B
2 10.07 MIR199A1 MIR145

GO Terms for Cervix Small Cell Carcinoma

Cellular components related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.5 MIRLET7C MIR145 MIR143 MIR125B1 MIR10B ENO2
2 extracellular vesicle GO:1903561 9.33 MIRLET7C MIR125B1 MIR100
3 extracellular space GO:0005615 9.28 MIRLET7C MIR199A1 MIR143 MIR125B1 MIR10B MIR100

Biological processes related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of angiogenesis GO:0016525 9.63 MIR145 MIR143 MIR125B1
2 negative regulation of smooth muscle cell proliferation GO:0048662 9.49 MIR145 MIR143
3 regulation of smooth muscle contraction GO:0006940 9.48 MIR145 MIR143
4 negative regulation of interleukin-6-mediated signaling pathway GO:0070104 9.43 MIRLET7C MIR125B1
5 angiotensin-activated signaling pathway GO:0038166 9.4 MIR145 MIR143
6 negative regulation of STAT cascade GO:1904893 9.37 MIRLET7C MIR125B1
7 aorta smooth muscle tissue morphogenesis GO:0060414 9.32 MIR145 MIR143
8 regulation of phenotypic switching GO:1900239 9.26 MIR145 MIR143
9 miRNA mediated inhibition of translation GO:0035278 9.26 MIR145 MIR125B1 MIR10B MIR100
10 gene silencing by miRNA GO:0035195 9.17 MIRLET7C MIR199A1 MIR145 MIR143 MIR125B1 MIR10B
11 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 9.16 MIR145 MIR143

Molecular functions related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.17 MIRLET7C MIR199A1 MIR145 MIR143 MIR125B1 MIR10B
2 mRNA 3'-UTR binding GO:0003730 9.13 MIR145 MIR143 MIR10B

Sources for Cervix Small Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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