MCID: CRV022
MIFTS: 42

Cervix Small Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervix Small Cell Carcinoma

MalaCards integrated aliases for Cervix Small Cell Carcinoma:

Name: Cervix Small Cell Carcinoma 12 15
Small Cell Carcinoma of the Cervix 12 74
Small Cell Carcinoma of the Cervix Uteri 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6740
NCIt 51 C7982
UMLS 74 C0279674

Summaries for Cervix Small Cell Carcinoma

MalaCards based summary : Cervix Small Cell Carcinoma, also known as small cell carcinoma of the cervix, is related to small cell carcinoma and cervix carcinoma. An important gene associated with Cervix Small Cell Carcinoma is ENO2 (Enolase 2), and among its related pathways/superpathways are ERK Signaling and WNT Signaling. The drugs Cisplatin and Panitumumab have been mentioned in the context of this disorder. Affiliated tissues include cervix, lung and lymph node, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Cervix Small Cell Carcinoma

Diseases related to Cervix Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma 30.3 CDKN2A CHGA ENO2 NCAM1 SYP TP53
2 cervix carcinoma 29.9 CDKN2A MAPK8IP1 MAPK8IP2 TP53
3 extraosseous chondrosarcoma 10.5 ENO2 SYP
4 subependymal glioma 10.5 ENO2 SYP
5 clear cell ependymoma 10.5 ENO2 SYP
6 astroblastoma 10.5 ENO2 SYP
7 goblet cell carcinoid 10.5 CHGA ENO2
8 chordoid meningioma 10.5 CHGA SYP
9 middle cerebral artery infarction 10.5 ENO2 NCAM1
10 hypoganglionosis 10.5 NCAM1 SYP
11 endocervical carcinoma 10.5 CDKN2A MAPK8IP1
12 sella turcica neoplasm 10.5 POMC SYP
13 tuberculum sellae meningioma 10.5 POMC SYP
14 carotid body cancer 10.5 ENO2 SYP
15 pituitary carcinoma 10.5 CHGA POMC
16 ureter small cell carcinoma 10.4 CHGA SYP
17 malignant sertoli cell tumor 10.4 ENO2 SYP
18 intracranial primitive neuroectodermal tumor 10.4 CHGA ENO2
19 multiple mucosal neuroma 10.4 ENO2 NCAM1
20 sinonasal undifferentiated carcinoma 10.4 ENO2 SYP
21 acinar cell cystadenocarcinoma 10.4 CHGA SYP
22 lung meningioma 10.4 ENO2 NCAM1
23 vulva squamous cell carcinoma 10.4 CDKN2A TP53
24 scrotal carcinoma 10.4 CDKN2A TP53
25 bladder carcinoma in situ 10.4 CDKN2A TP53
26 spitz nevus 10.4 CDKN2A TP53
27 lung combined type small cell carcinoma 10.4 NCAM1 SYP
28 pancreatic somatostatinoma 10.4 ENO2 SYP
29 peritoneal serous adenocarcinoma 10.4 CHGA SYP
30 urinary bladder small cell neuroendocrine carcinoma 10.4 CHGA ENO2 SYP
31 auditory system cancer 10.4 CHGA ENO2 SYP
32 small cell carcinoma of the bladder 10.4 CHGA ENO2 SYP
33 inappropriate adh syndrome 10.4 AVP POMC
34 primary hepatic neuroendocrine carcinoma 10.4 CHGA SYP
35 pulmonary large cell neuroendocrine carcinoma 10.4 CHGA ENO2 SYP
36 cauda equina neoplasm 10.4 CHGA ENO2 SYP
37 papillary tumor of the pineal region 10.4 ENO2 SYP
38 autonomic nervous system benign neoplasm 10.4 CHGA ENO2 SYP
39 nodular ganglioneuroblastoma 10.4 CHGA ENO2 SYP
40 pineocytoma 10.4 CHGA ENO2 SYP
41 carcinoid tumors, intestinal 10.4 CHGA ENO2 SYP
42 respiratory system benign neoplasm 10.4 CHGA ENO2 SYP
43 cutaneous ganglioneuroma 10.4 ENO2 NCAM1 SYP
44 extrahepatic bile duct adenocarcinoma 10.4 ENO2 NCAM1 SYP
45 orbital cancer 10.4 ENO2 NCAM1 SYP
46 papillary ependymoma 10.4 CHGA ENO2 SYP
47 central neurocytoma 10.3 CHGA ENO2 SYP
48 endometrial small cell carcinoma 10.3 ENO2 NCAM1 SYP
49 choriocarcinoma of ovary 10.3 ENO2 NCAM1
50 carcinoid syndrome 10.3 CHGA ENO2 SYP

Graphical network of the top 20 diseases related to Cervix Small Cell Carcinoma:



Diseases related to Cervix Small Cell Carcinoma

Symptoms & Phenotypes for Cervix Small Cell Carcinoma

MGI Mouse Phenotypes related to Cervix Small Cell Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 AVP CDKN2A ENO2 MAPK8IP1 MAPK8IP2 NCAM1
2 homeostasis/metabolism MP:0005376 9.9 AVP CDH2 CDKN2A CHGA CNN1 CXCR2
3 endocrine/exocrine gland MP:0005379 9.86 CDH3 CDKN2A CHGA CXCR2 MAPK8IP1 MAPK8IP2
4 mortality/aging MP:0010768 9.73 AVP CDH2 CDKN2A CHGA CNN1 CXCR2
5 nervous system MP:0003631 9.44 AVP CDH2 CDKN2A CHGA CXCR2 ENO2

Drugs & Therapeutics for Cervix Small Cell Carcinoma

Drugs for Cervix Small Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2,Phase 1 15663-27-1 2767 441203 84093
2
Panitumumab Approved, Investigational Phase 2 339177-26-3 50070211
3
Paclitaxel Approved, Vet_approved Phase 2,Phase 1 33069-62-4 36314
4
Lenograstim Approved, Investigational Phase 2 135968-09-1
5
Topotecan Approved, Investigational Phase 2 119413-54-6, 123948-87-8 60700
6
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
7
Cetuximab Approved Phase 2,Phase 1 205923-56-4 56842117 2333
8
Veliparib Investigational Phase 2 912444-00-9 11960529
9 Antineoplastic Agents, Immunological Phase 2,Phase 1
10 Antineoplastic Agents, Phytogenic Phase 2,Phase 1
11 Albumin-Bound Paclitaxel Phase 2,Phase 1
12 Antimitotic Agents Phase 2,Phase 1
13 Adjuvants, Immunologic Phase 2
14 topoisomerase I inhibitors Phase 2
15 Immunologic Factors Phase 2,Phase 1
16 Topoisomerase Inhibitors Phase 2
17 Poly(ADP-ribose) Polymerase Inhibitors Phase 2
18 Radiopharmaceuticals Phase 1, Phase 2
19 Fluorodeoxyglucose F18 Phase 1, Phase 2
20
Gemcitabine Approved Phase 1 95058-81-4 60750
21 Antimetabolites Phase 1
22 Anti-Infective Agents Phase 1
23 Immunosuppressive Agents Phase 1
24 Antiviral Agents Phase 1
25 Antimetabolites, Antineoplastic Phase 1
26
Formaldehyde Approved, Vet_approved 50-00-0 712
27 Antibiotics, Antitubercular
28 Radiation-Protective Agents
29 Protective Agents
30 Anti-Bacterial Agents
31 Interferon Inducers
32 interferons
33 polysaccharide-K

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Panitumumab, Cisplatin, and Pelvic Radiation Therapy in Treating Patients With Stage IB, Stage II, or Stage III Cervical Cancer Unknown status NCT01158248 Phase 2 cisplatin
2 ABI-007 in Treating Patients With Persistent or Recurrent Cervical Cancer Completed NCT00309959 Phase 2 Paclitaxel Albumin-Stabilized Nanoparticle Formulation
3 Pelvic Exenteration in Treating Patients With Recurrent Cervical Cancer Completed NCT00217633 Phase 2
4 Veliparib, Topotecan Hydrochloride, and Filgrastim or Pegfilgrastim in Treating Patients With Persistent or Recurrent Cervical Cancer Completed NCT01266447 Phase 2 Topotecan Hydrochloride;Veliparib
5 Fludeoxyglucose (FDG) F 18 PET Scan, CT Scan, and Ferumoxtran-10 MRI Scan Before Chemotherapy and Radiation Therapy in Finding Lymph Node Metastasis in Patients With Locally Advanced Cervical Cancer or High-Risk Endometrial Cancer Completed NCT00416455 Phase 1, Phase 2 ferumoxtran-10
6 ADXS11-001 High Dose HPV+ Cervical Cancer Completed NCT02164461 Phase 1, Phase 2
7 Cetuximab and Cisplatin in Treating Patients With Advanced, Persistent, or Recurrent Cervical Cancer Completed NCT00101192 Phase 2 cisplatin
8 Paclitaxel, Topotecan, and Cisplatin in Treating Patients With Advanced, Persistent, or Recurrent Cervical Cancer Completed NCT00276796 Phase 2 cisplatin;paclitaxel;topotecan hydrochloride
9 Radiation Therapy Plus Paclitaxel and Cisplatin in Treating Patients With Cervical Cancer Completed NCT00003379 Phase 1, Phase 2 cisplatin;paclitaxel
10 Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer Completed NCT00104910 Phase 1 Cisplatin
11 Radiation Therapy Plus Cisplatin and Gemcitabine in Treating Patients With Cervical Cancer Completed NCT00068549 Phase 1 Gemcitabine Hydrochloride;Cisplatin
12 Glycoprotein and Glycan in Tissue and Blood Samples of Patients With Stage IB-IVA Cervical Cancer Undergoing Surgery to Remove Pelvic and Abdominal Lymph Nodes Completed NCT00460356
13 Collecting Tumor Samples From Patients With Gynecological Tumors Completed NCT00897442
14 Use of Social Networking to Survey Women With Small and Large Cell Carcinomas of the Cervix Recruiting NCT01606293

Search NIH Clinical Center for Cervix Small Cell Carcinoma

Genetic Tests for Cervix Small Cell Carcinoma

Anatomical Context for Cervix Small Cell Carcinoma

MalaCards organs/tissues related to Cervix Small Cell Carcinoma:

42
Cervix, Lung, Lymph Node, Breast, Ovary, Pancreas, Thyroid

Publications for Cervix Small Cell Carcinoma

Articles related to Cervix Small Cell Carcinoma:

(show all 48)
# Title Authors Year
1
Lambert-Eaton Myasthenic Syndrome Associated with Synchronous Double Cancer: A Combination of Small Cell Carcinoma of the Cervix and Breast Carcinoma. ( 29526952 )
2018
2
Advanced small cell carcinoma of the cervix - Successful treatment with concurrent etoposide and cisplatin chemotherapy and extended field radiation: A case report and discussion. ( 29255785 )
2018
3
Influence of clinicopathological characteristics and comprehensive treatment models on the prognosis of small cell carcinoma of the cervix: A systematic review and meta-analysis. ( 29641578 )
2018
4
Prognostic value of lymph node ratio in patients with small-cell carcinoma of the cervix based on data from a large national registry. ( 26730205 )
2016
5
The local treatment modalities in FIGO stage I-II small-cell carcinoma of the cervix are determined by disease stage and lymph node status. ( 26990881 )
2016
6
Adenocarcinoma of the cervix associated with a neuroendocrine small cell carcinoma of the cervix in the spectrum of Muir-Torre syndrome. ( 26050364 )
2015
7
Metastatic small cell carcinoma of the cervix to the oral cavity: A rare case report and an insight into pathogenesis of metastasis. ( 26604504 )
2015
8
Radiation sensitivity assay with a panel of patient-derived spheroids of small cell carcinoma of the cervix. ( 25408479 )
2015
9
Prognostic risk factors for small cell carcinoma of the cervix and impact of platinum-based neoadjuvant chemotherapy. ( 25890393 )
2015
10
Small cell carcinoma of the cervix at 32-week gestation: a case report and review of the literature. ( 24719986 )
2014
11
Gynecologic Cancer InterGroup (GCIG) consensus review for small cell carcinoma of the cervix. ( 25341572 )
2014
12
Metastatic small-cell carcinoma of the cervix during pregnancy. ( 24456456 )
2014
13
Downregulation of six microRNAs is associated with advanced stage, lymph node metastasis and poor prognosis in small cell carcinoma of the cervix. ( 22438992 )
2012
14
Chromogranin A (CgA) as poor prognostic factor in patients with small cell carcinoma of the cervix: results of a retrospective study of 293 patients. ( 22529895 )
2012
15
Small cell carcinoma of the cervix in liquid-based Pap test: utilization of split-sample immunocytochemical and molecular analysis. ( 20891001 )
2012
16
Small-cell carcinoma of the cervix at 23 weeks gestation. ( 20385993 )
2010
17
Small cell carcinoma of the cervix: treatment and survival outcomes of 188 patients. ( 20579961 )
2010
18
Clinicopathological features and prognosis of small cell carcinoma of the cervix. ( 21063846 )
2010
19
Small cell carcinoma of the cervix presenting with acute vaginal hemorrhage: a case report. ( 18455059 )
2008
20
Incidence, mortality, and prognostic factors of small cell carcinoma of the cervix. ( 18515524 )
2008
21
Small cell carcinoma of the cervix: a case report. ( 17828547 )
2008
22
Neuroendocrine small cell carcinoma of the cervix associated with endocervical adenocarcinoma: a case report. ( 17718130 )
2007
23
Small-cell carcinoma of the cervix: fourteen years of experience at a single institution using a combined-modality regimen of involved-field irradiation and platinum-based combination chemotherapy. ( 12972526 )
2003
24
Small cell carcinoma of the cervix: a clinicopathologic and immunohistochemical study of 23 cases. ( 12478483 )
2002
25
Predictors of outcome in small cell carcinoma of the cervix--a case series. ( 11606074 )
2001
26
Small cell carcinoma of the cervix complicated by pregnancy. ( 10378639 )
1999
27
Hypoglycemia due to an insulin-secreting small-cell carcinoma of the cervix. ( 10471459 )
1999
28
Treatment resistant small cell carcinoma of the cervix. ( 10575314 )
1999
29
Small cell carcinoma of the cervix: a clinical study of 15 patients and review of the literature. ( 10838295 )
1998
30
Small cell carcinoma of the cervix: analysis of clinical and pathological findings. ( 9611065 )
1998
31
Small-Cell Carcinoma of the Cervix Presenting with Severe Hypokalemia as a Manifestation of Cushing's Syndrome. ( 25951213 )
1997
32
Efficacy of radical hysterectomy as treatment for patients with small cell carcinoma of the cervix. ( 8608533 )
1996
33
Small cell carcinoma of the cervix of neuroendocrine origin causing obstructed labour. ( 8775261 )
1996
34
Successful treatment of neuroendocrine small cell carcinoma of the cervix metastatic to regional lymph nodes. ( 8812543 )
1996
35
Small cell carcinoma of the cervix. ( 8859607 )
1996
36
Adjuvant chemotherapy in stage IB neuroendocrine small cell carcinoma of the cervix. ( 7572111 )
1995
37
Small cell carcinoma of the cervix treated with concurrent radiotherapy, cisplatin, and etoposide. ( 7896189 )
1995
38
Small cell carcinoma of the cervix. ( 11578477 )
1995
39
Small cell carcinoma of the cervix. A clinicopathologic study of 26 patients. ( 8299089 )
1994
40
Overexpression of p53 protein and c-erbB-2 protein in small cell carcinoma of the cervix uteri. ( 8103676 )
1993
41
Treatment of small cell carcinoma of the cervix with cisplatin, doxorubicin, and etoposide. ( 1330847 )
1992
42
Adjuvant therapy for neuroendocrine small cell carcinoma of the cervix: review of the literature. ( 1660433 )
1991
43
Small cell carcinoma of the cervix: a clinical and flow-cytometric study. ( 1655594 )
1991
44
Treatment of small-cell carcinoma of the cervix with weekly combination chemotherapy. ( 1697475 )
1990
45
Small cell carcinoma of the cervix with inappropriate antidiuretic hormone secretion. Case report. ( 2167728 )
1990
46
Simultaneous small cell carcinoma of the cervix and adenocarcinoma of the ovary. ( 2172123 )
1990
47
Eaton-Lambert syndrome as a harbinger of recurrent small-cell carcinoma of the cervix with improvement after combination chemotherapy. ( 2841632 )
1988
48
The pathologic spectrum of small cell carcinoma of the cervix. ( 2852175 )
1985

Variations for Cervix Small Cell Carcinoma

Cosmic variations for Cervix Small Cell Carcinoma:

9 (show all 21)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6932 TP53 cervix,NS,carcinoma,small cell carcinoma c.733G>A p.G245S 17:7674230-7674230 0
2 COSM44676 TP53 cervix,NS,carcinoma,small cell carcinoma c.714T>G p.C238W 17:7674249-7674249 0
3 COSM43706 TP53 cervix,NS,carcinoma,small cell carcinoma c.811G>C p.E271Q 17:7673809-7673809 0
4 COSM10893 TP53 cervix,NS,carcinoma,small cell carcinoma c.824G>A p.C275Y 17:7673796-7673796 0
5 COSM145923 SF3B1 cervix,NS,carcinoma,small cell carcinoma c.2225G>A p.G742D 2:197401887-197401887 0
6 COSM6943414 RPS6KB2 cervix,NS,carcinoma,small cell carcinoma c.356A>C p.E119A 11:67431414-67431414 0
7 COSM6943412 RAD54L cervix,NS,carcinoma,small cell carcinoma c.388G>T p.D130Y 1:46260080-46260080 0
8 COSM5126 PTEN cervix,NS,carcinoma,small cell carcinoma c.722T>C p.F241S 10:87957940-87957940 0
9 COSM5123 PTEN cervix,NS,carcinoma,small cell carcinoma c.395G>A p.G132D 10:87933154-87933154 0
10 COSM166339 PIK3CA cervix,NS,carcinoma,small cell carcinoma c.317G>C p.G106A 3:179199142-179199142 0
11 COSM765 PIK3CA cervix,NS,carcinoma,small cell carcinoma c.1635G>T p.E545D 3:179218305-179218305 0
12 COSM763 PIK3CA cervix,NS,carcinoma,small cell carcinoma c.1633G>A p.E545K 3:179218303-179218303 0
13 COSM446002 PIK3CA cervix,NS,carcinoma,small cell carcinoma c.1034A>C p.N345T 3:179203764-179203764 0
14 COSM760 PIK3CA cervix,NS,carcinoma,small cell carcinoma c.1624G>A p.E542K 3:179218294-179218294 0
15 COSM28657 NOTCH1 cervix,NS,carcinoma,small cell carcinoma c.6943C>T p.Q2315* 9:136496796-136496796 0
16 COSM520 KRAS cervix,NS,carcinoma,small cell carcinoma c.35G>T p.G12V 12:25245350-25245350 0
17 COSM3832368 KMT2C cervix,NS,carcinoma,small cell carcinoma c.4174C>T p.Q1392* 7:152199378-152199378 0
18 COSM436498 ERBB2 cervix,NS,carcinoma,small cell carcinoma c.2033G>A p.R678Q 17:39723405-39723405 0
19 COSM3832367 cervix,NS,carcinoma,small cell carcinoma c.4174C>T p.Q1392* 7:152199378-152199378 0
20 COSM125370 cervix,NS,carcinoma,small cell carcinoma c.1633G>A p.E545K 3:179218303-179218303 0
21 COSM6943413 cervix,NS,carcinoma,small cell carcinoma c.356A>C p.E119A 11:67431414-67431414 0

Expression for Cervix Small Cell Carcinoma

Search GEO for disease gene expression data for Cervix Small Cell Carcinoma.

Pathways for Cervix Small Cell Carcinoma

GO Terms for Cervix Small Cell Carcinoma

Cellular components related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.65 CDH17 CDH2 CDH3 CXCR2 NCAM1
2 secretory granule GO:0030141 9.33 AVP CHGA POMC
3 cell-cell adherens junction GO:0005913 9.13 CDH17 CDH2 CDH3
4 catenin complex GO:0016342 8.8 CDH17 CDH2 CDH3

Biological processes related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil chemotaxis GO:0030593 9.58 CXCL1 CXCR1 CXCR2
2 chemokine-mediated signaling pathway GO:0070098 9.54 CXCL1 CXCR1 CXCR2
3 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 9.5 CDH17 CDH2 CDH3
4 dendritic cell chemotaxis GO:0002407 9.46 CXCR1 CXCR2
5 replicative senescence GO:0090399 9.43 CDKN2A TP53
6 cell-cell junction assembly GO:0007043 9.43 CDH17 CDH2 CDH3
7 adherens junction organization GO:0034332 9.33 CDH17 CDH2 CDH3
8 cell-cell adhesion mediated by cadherin GO:0044331 9.13 CDH17 CDH2 CDH3
9 interleukin-8-mediated signaling pathway GO:0038112 8.62 CXCR1 CXCR2

Molecular functions related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.55 CDH2 CDKN2A MAPK8IP1 MAPK8IP2 TP53
2 cytoskeletal protein binding GO:0008092 9.54 CDH17 CDH2 CDH3
3 C-X-C chemokine receptor activity GO:0016494 9.32 CXCR1 CXCR2
4 MAP-kinase scaffold activity GO:0005078 9.26 MAPK8IP1 MAPK8IP2
5 interleukin-8 binding GO:0019959 8.96 CXCR1 CXCR2
6 interleukin-8 receptor activity GO:0004918 8.62 CXCR1 CXCR2

Sources for Cervix Small Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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