MCID: CRV022
MIFTS: 34

Cervix Small Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases
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Aliases & Classifications for Cervix Small Cell Carcinoma

MalaCards integrated aliases for Cervix Small Cell Carcinoma:

Name: Cervix Small Cell Carcinoma 11 14
Small Cell Carcinoma of the Cervix 11 71
Small Cell Carcinoma of the Cervix Uteri 11

Classifications:



External Ids:

Disease Ontology 11 DOID:6740
NCIt 49 C7982
UMLS 71 C0279674

Summaries for Cervix Small Cell Carcinoma

MalaCards based summary: Cervix Small Cell Carcinoma, also known as small cell carcinoma of the cervix, is related to neuroendocrine carcinoma and small cell cancer of the lung. An important gene associated with Cervix Small Cell Carcinoma is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are Cell differentiation - expanded index and OSX and miRNAs in tooth development. Affiliated tissues include cervix, lymph node and uterus.

Related Diseases for Cervix Small Cell Carcinoma

Diseases related to Cervix Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 319)
# Related Disease Score Top Affiliating Genes
1 neuroendocrine carcinoma 30.5 SYP NCAM1 ENO2 CHGA
2 small cell cancer of the lung 30.4 SYP NCAM1 ENO2 CHGA
3 carcinoid tumors, intestinal 30.3 SYP ENO2 CHGA
4 lung oat cell carcinoma 30.3 SYP ENO2 CHGA
5 neuroendocrine tumor 30.2 SYP NCAM1 ENO2 CHGA
6 large cell neuroendocrine carcinoma 29.9 SYP NCAM1 ENO2 CHGA
7 merkel cell carcinoma 29.9 SYP NCAM1 ENO2 CHGA
8 small cell carcinoma 29.8 SYP NCAM1 ENO2 CHGA
9 lung cancer 27.8 SYP NCAM1 MIRLET7C MIR199A1 MIR145 MIR143
10 cervix carcinoma 10.4
11 cervical cancer 10.4
12 squamous cell carcinoma 10.4
13 suppressor of tumorigenicity 3 10.3
14 perivascular tumor 10.3 SYP ENO2
15 papillary squamous carcinoma 10.3 SYP MAPK8IP1
16 malignant melanocytic neoplasm of the peripheral nerve sheath 10.3 SYP ENO2
17 neuronal intestinal dysplasia, type b 10.3 SYP ENO2
18 optic nerve astrocytoma 10.3 SYP ENO2
19 cloacogenic carcinoma 10.3 SYP ENO2
20 pineal region teratoma 10.3 SYP ENO2
21 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.3 SYP ENO2
22 bile duct mucinous adenocarcinoma 10.3 SYP ENO2
23 partial cryptophthalmia 10.3 SYP ENO2
24 intracranial primitive neuroectodermal tumor 10.3 SYP ENO2
25 cerebellar liponeurocytoma 10.3 SYP ENO2
26 frontal lobe neoplasm 10.3 SYP ENO2
27 lipoma of spermatic cord 10.3 SYP ENO2
28 jejunal neoplasm 10.3 SYP ENO2
29 melanotic neuroectodermal tumor 10.3 SYP ENO2
30 pancreas lymphoma 10.3 SYP CHGA
31 paratesticular lipoma 10.3 SYP ENO2
32 vaginal tubulovillous adenoma 10.3 SYP CHGA
33 mixed ductal-endocrine carcinoma 10.3 SYP CHGA
34 vulvar eccrine porocarcinoma 10.3 SYP CHGA
35 cervical large cell neuroendocrine carcinoma 10.3 SYP CHGA
36 prostate small cell carcinoma 10.3 SYP ENO2
37 vaginal glandular tumor 10.3 ENO2 CHGA
38 central nervous system mesenchymal non-meningothelial tumor 10.3 SYP ENO2
39 duodenal benign neoplasm 10.3 SYP CHGA
40 ectomesenchymoma 10.3 SYP ENO2
41 mature teratoma 10.3 SYP ENO2
42 acinar cell cystadenocarcinoma 10.3 SYP CHGA
43 mature teratoma of the ovary 10.3 SYP ENO2
44 glomus tumor 10.3 SYP ENO2
45 myoblastoma 10.3 SYP ENO2
46 breast papillary carcinoma 10.3 SYP CHGA
47 spinal cord oligodendroglioma 10.3 SYP ENO2
48 gastric gastrinoma 10.3 SYP CHGA
49 ectopic cushing syndrome 10.3 SYP CHGA
50 binswanger's disease 10.3 SYP CHGA

Graphical network of the top 20 diseases related to Cervix Small Cell Carcinoma:



Diseases related to Cervix Small Cell Carcinoma

Symptoms & Phenotypes for Cervix Small Cell Carcinoma

Drugs & Therapeutics for Cervix Small Cell Carcinoma

Search Clinical Trials, NIH Clinical Center for Cervix Small Cell Carcinoma

Genetic Tests for Cervix Small Cell Carcinoma

Anatomical Context for Cervix Small Cell Carcinoma

Organs/tissues related to Cervix Small Cell Carcinoma:

MalaCards : Cervix, Lymph Node, Uterus, Ovary, Breast, Bone

Publications for Cervix Small Cell Carcinoma

Articles related to Cervix Small Cell Carcinoma:

(show top 50) (show all 100)
# Title Authors PMID Year
1
Small Cell and Other Rare Histologic Types of Cervical Cancer. 62
35947285 2022
2
Overexpression of Karyopherin α2 in small cell carcinoma of the cervix correlates with poor prognosis. 62
35795090 2022
3
A Rare Case of Paraneoplastic Syndrome of Inappropriate Secretion of Antidiuretic Hormone in Cervical Squamous Cell Carcinoma; A Case Report and Literature Review. 62
36262503 2022
4
The importance of choosing the right strategy to treat small cell carcinoma of the cervix: a comparative analysis of treatments. 62
34556082 2021
5
Neuroendocrine small cell carcinoma of the cervix: A case report. 62
33767861 2021
6
Optimal treatment strategies for small cell carcinoma of the uterine cervix: A retrospective multi-center study (KROG 19-03). 62
33545454 2021
7
Small cell carcinoma of the cervix complicated by syndrome of inappropriate antidiuretic hormone secretion: a case report. 62
33596689 2021
8
Case Report: Circulating Tumor DNA Fraction Analysis Using Ultra-Low-Pass Whole-Genome Sequencing Correlates Response to Chemoradiation and Recurrence in Stage IV Small-Cell Carcinoma of the Cervix - A Longitudinal Study. 62
34381704 2021
9
Trends and predictors of survival for small cell carcinoma of the cervix uteri: A SEER population study. 62
32768799 2020
10
Patterns of Care and Outcomes for Small Cell Carcinoma of the Cervix: A National Retrospective Analysis of 542 Cases. 62
32529135 2020
11
Cervix neuroendocrine carcinoma presenting with severe hypokalemia and Cushing's syndrome. 62
31970585 2020
12
Prognostic Factors and Local Treatment Modalities of Small-Cell Carcinoma of the Cervix: An Analysis According to the International Federation of Gynecology and Obstetrics Stage. 62
32523375 2020
13
Erratum: Prognostic Factors and Local Treatment Modalities of Small-Cell Carcinoma of the Cervix: An Analysis According to the International Federation of Gynecology and Obstetrics Stage [Corrigendum]. 62
32884338 2020
14
Postoperative adjuvant radiation improves local control in surgically treated FIGO stage I-II small cell carcinoma of the cervix. 62
31722727 2019
15
Rare Hereditary Burden associated with a Hypercalcemic Small-Cell Carcinoma of Cervix in a Young Female Patient. 62
31842565 2019
16
Lambert-Eaton Myasthenic Syndrome Associated with Synchronous Double Cancer: A Combination of Small Cell Carcinoma of the Cervix and Breast Carcinoma. 62
29526952 2018
17
Advanced small cell carcinoma of the cervix - Successful treatment with concurrent etoposide and cisplatin chemotherapy and extended field radiation: A case report and discussion. 62
29255785 2018
18
Influence of clinicopathological characteristics and comprehensive treatment models on the prognosis of small cell carcinoma of the cervix: A systematic review and meta-analysis. 62
29641578 2018
19
Clinicopathological features of small cell carcinoma of the uterine cervix in the surveillance, epidemiology, and end results database. 62
28415576 2017
20
Early Detection of Bone Metastasis in Small Cell Neuroendocrine Carcinoma of the Cervix by 68Ga-DOTATATE PET/CT Imaging. 62
28005640 2017
21
The local treatment modalities in FIGO stage I-II small-cell carcinoma of the cervix are determined by disease stage and lymph node status. 62
26990881 2016
22
Prognostic value of lymph node ratio in patients with small-cell carcinoma of the cervix based on data from a large national registry. 62
26730205 2016
23
Prognostic risk factors for small cell carcinoma of the cervix and impact of platinum-based neoadjuvant chemotherapy. 62
25890393 2015
24
Radiation sensitivity assay with a panel of patient-derived spheroids of small cell carcinoma of the cervix. 62
25408479 2015
25
Metastatic small cell carcinoma of the cervix to the oral cavity: A rare case report and an insight into pathogenesis of metastasis. 62
26604504 2015
26
Adenocarcinoma of the cervix associated with a neuroendocrine small cell carcinoma of the cervix in the spectrum of Muir-Torre syndrome. 62
26050364 2015
27
Gynecologic Cancer InterGroup (GCIG) consensus review for small cell carcinoma of the cervix. 62
25341572 2014
28
Metastatic small-cell carcinoma of the cervix during pregnancy. 62
24456456 2014
29
Small cell neuroendocrine carcinoma of the cervix: a rare entity. 62
24701511 2014
30
Small cell carcinoma of the uterine cervix in a pregnant patient diagnosed with liquid based cytology and cell block immunocytochemistry. 62
25254132 2014
31
Small cell carcinoma of the cervix at 32-week gestation: a case report and review of the literature. 62
24719986 2014
32
Small cell neuroendocrine carcinoma of the uterine cervix presenting with syndrome of inappropriate antidiuretic hormone secretion. 62
24396824 2013
33
The management of small-cell carcinomas of the gynecologic tract. 62
22820410 2012
34
Small cell carcinoma of the cervix in liquid-based Pap test: utilization of split-sample immunocytochemical and molecular analysis. 62
20891001 2012
35
Chromogranin A (CgA) as poor prognostic factor in patients with small cell carcinoma of the cervix: results of a retrospective study of 293 patients. 62
22529895 2012
36
Downregulation of six microRNAs is associated with advanced stage, lymph node metastasis and poor prognosis in small cell carcinoma of the cervix. 62
22438992 2012
37
p16(INK4a) and ProEx C immunostains facilitate differential diagnosis of hyperchromatic crowded groups in liquid-based Papanicolaou tests with menstrual contamination. 62
22236746 2012
38
A clinicopathological aspect of primary small-cell carcinoma of the uterine cervix: a single-centre study of 25 cases. 62
21965825 2011
39
Small cell carcinoma of the cervix: treatment and survival outcomes of 188 patients. 62
20579961 2010
40
Clinicopathological features and prognosis of small cell carcinoma of the cervix. 62
21063846 2010
41
Small-cell carcinoma of the cervix at 23 weeks gestation. 62
20385993 2010
42
Small cell cervical cancer: an unusual finding at cholecystectomy. 62
18548263 2009
43
[Cervix small cell carcinoma: report of a case]. 62
19035126 2008
44
Incidence, mortality, and prognostic factors of small cell carcinoma of the cervix. 62
18515524 2008
45
Small cell carcinoma of the cervix presenting with acute vaginal hemorrhage: a case report. 62
18455059 2008
46
Small cell carcinoma of the cervix: a case report. 62
17828547 2008
47
[Clinicopathologic characteristics of eight patients with small cell carcinoma of the cervix]. 62
18788567 2008
48
Neuroendocrine small cell carcinoma of the cervix associated with endocervical adenocarcinoma: a case report. 62
17718130 2007
49
Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer. 62
16865269 2006
50
Small cell neuroendocrine carcinoma of the cervix: outcome and patterns of recurrence. 62
15047210 2004

Variations for Cervix Small Cell Carcinoma

Cosmic variations for Cervix Small Cell Carcinoma:

8 (show top 50) (show all 114)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM143944022 TP53 cervix,NS,carcinoma,small cell carcinoma c.347G>A p.C116Y 17:7673796-7673796 9
2 COSM144088917 TP53 cervix,NS,carcinoma,small cell carcinoma c.334G>C p.E112Q 17:7673809-7673809 9
3 COSM144317223 TP53 cervix,NS,carcinoma,small cell carcinoma c.597T>G p.C199W 17:7674249-7674249 9
4 COSM144310384 TP53 cervix,NS,carcinoma,small cell carcinoma c.707G>A p.C236Y 17:7673796-7673796 9
5 COSM142837497 TP53 cervix,NS,carcinoma,small cell carcinoma c.733G>A p.G245S 17:7674230-7674230 9
6 COSM144013587 TP53 cervix,NS,carcinoma,small cell carcinoma c.700G>A p.G234S 17:7674230-7674230 9
7 COSM143158932 TP53 cervix,NS,carcinoma,small cell carcinoma c.334G>C p.E112Q 17:7673809-7673809 9
8 COSM93186154 TP53 cervix,NS,carcinoma,small cell carcinoma c.811G>C p.E271Q 17:7673809-7673809 9
9 COSM122271749 TP53 cervix,NS,carcinoma,small cell carcinoma c.337G>A p.G113S 17:7674230-7674230 9
10 COSM111758803 TP53 cervix,NS,carcinoma,small cell carcinoma c.824G>A p.C275Y 17:7673796-7673796 9
11 COSM93183907 TP53 cervix,NS,carcinoma,small cell carcinoma c.824G>A p.C275Y 17:7673796-7673796 9
12 COSM144310364 TP53 cervix,NS,carcinoma,small cell carcinoma c.616G>A p.G206S 17:7674230-7674230 9
13 COSM142837517 TP53 cervix,NS,carcinoma,small cell carcinoma c.824G>A p.C275Y 17:7673796-7673796 9
14 COSM144651337 TP53 cervix,NS,carcinoma,small cell carcinoma c.616G>A p.G206S 17:7674230-7674230 9
15 COSM142839064 TP53 cervix,NS,carcinoma,small cell carcinoma c.811G>C p.E271Q 17:7673809-7673809 9
16 COSM112261636 TP53 cervix,NS,carcinoma,small cell carcinoma c.714T>G p.C238W 17:7674249-7674249 9
17 COSM143371097 TP53 cervix,NS,carcinoma,small cell carcinoma c.707G>A p.C236Y 17:7673796-7673796 9
18 COSM121886439 TP53 cervix,NS,carcinoma,small cell carcinoma c.318T>G p.C106W 17:7674249-7674249 9
19 COSM144093373 TP53 cervix,NS,carcinoma,small cell carcinoma c.237T>G p.C79W 17:7674249-7674249 9
20 COSM122734335 TP53 cervix,NS,carcinoma,small cell carcinoma c.337G>A p.G113S 17:7674230-7674230 9
21 COSM143156960 TP53 cervix,NS,carcinoma,small cell carcinoma c.256G>A p.G86S 17:7674230-7674230 9
22 COSM105620519 TP53 cervix,NS,carcinoma,small cell carcinoma c.733G>A p.G245S 17:7674230-7674230 9
23 COSM106061693 TP53 cervix,NS,carcinoma,small cell carcinoma c.714T>G p.C238W 17:7674249-7674249 9
24 COSM144312263 TP53 cervix,NS,carcinoma,small cell carcinoma c.694G>C p.E232Q 17:7673809-7673809 9
25 COSM143373342 TP53 cervix,NS,carcinoma,small cell carcinoma c.694G>C p.E232Q 17:7673809-7673809 9
26 COSM144654072 TP53 cervix,NS,carcinoma,small cell carcinoma c.694G>C p.E232Q 17:7673809-7673809 9
27 COSM105629290 TP53 cervix,NS,carcinoma,small cell carcinoma c.714T>G p.C238W 17:7674249-7674249 9
28 COSM122271777 TP53 cervix,NS,carcinoma,small cell carcinoma c.428G>A p.C143Y 17:7673796-7673796 9
29 COSM142560506 TP53 cervix,NS,carcinoma,small cell carcinoma c.707G>A p.C236Y 17:7673796-7673796 9
30 COSM111758775 TP53 cervix,NS,carcinoma,small cell carcinoma c.733G>A p.G245S 17:7674230-7674230 9
31 COSM144087244 TP53 cervix,NS,carcinoma,small cell carcinoma c.347G>A p.C116Y 17:7673796-7673796 9
32 COSM122736338 TP53 cervix,NS,carcinoma,small cell carcinoma c.415G>C p.E139Q 17:7673809-7673809 9
33 COSM111767926 TP53 cervix,NS,carcinoma,small cell carcinoma c.714T>G p.C238W 17:7674249-7674249 9
34 COSM144021901 TP53 cervix,NS,carcinoma,small cell carcinoma c.681T>G p.C227W 17:7674249-7674249 9
35 COSM142843633 TP53 cervix,NS,carcinoma,small cell carcinoma c.714T>G p.C238W 17:7674249-7674249 9
36 COSM143164074 TP53 cervix,NS,carcinoma,small cell carcinoma c.237T>G p.C79W 17:7674249-7674249 9
37 COSM87908196 TP53 cervix,NS,carcinoma,small cell carcinoma c.714T>G p.C238W 17:7674249-7674249 9
38 COSM93183877 TP53 cervix,NS,carcinoma,small cell carcinoma c.733G>A p.G245S 17:7674230-7674230 9
39 COSM145020497 TP53 cervix,NS,carcinoma,small cell carcinoma c.694G>C p.E232Q 17:7673809-7673809 9
40 COSM142568610 TP53 cervix,NS,carcinoma,small cell carcinoma c.597T>G p.C199W 17:7674249-7674249 9
41 COSM144660811 TP53 cervix,NS,carcinoma,small cell carcinoma c.597T>G p.C199W 17:7674249-7674249 9
42 COSM144015679 TP53 cervix,NS,carcinoma,small cell carcinoma c.778G>C p.E260Q 17:7673809-7673809 9
43 COSM145017887 TP53 cervix,NS,carcinoma,small cell carcinoma c.707G>A p.C236Y 17:7673796-7673796 9
44 COSM106053386 TP53 cervix,NS,carcinoma,small cell carcinoma c.824G>A p.C275Y 17:7673796-7673796 9
45 COSM106055520 TP53 cervix,NS,carcinoma,small cell carcinoma c.811G>C p.E271Q 17:7673809-7673809 9
46 COSM143371076 TP53 cervix,NS,carcinoma,small cell carcinoma c.616G>A p.G206S 17:7674230-7674230 9
47 COSM142560476 TP53 cervix,NS,carcinoma,small cell carcinoma c.616G>A p.G206S 17:7674230-7674230 9
48 COSM105622908 TP53 cervix,NS,carcinoma,small cell carcinoma c.782+372G>C p.? 17:7673809-7673809 9
49 COSM112255642 TP53 cervix,NS,carcinoma,small cell carcinoma c.811G>C p.E271Q 17:7673809-7673809 9
50 COSM143943997 TP53 cervix,NS,carcinoma,small cell carcinoma c.256G>A p.G86S 17:7674230-7674230 9

Expression for Cervix Small Cell Carcinoma

Search GEO for disease gene expression data for Cervix Small Cell Carcinoma.

Pathways for Cervix Small Cell Carcinoma

Pathways related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.03 MIR199A1 MIR145 MIR143
2 10.67 MIRLET7C MIR145
3 10.63 MIR145 MIR143 MIR100

GO Terms for Cervix Small Cell Carcinoma

Cellular components related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RISC complex GO:0016442 9.4 MIRLET7C MIR199A1 MIR145 MIR143 MIR10B MIR100

Biological processes related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 miRNA-mediated gene silencing GO:0035195 9.93 MIRLET7C MIR199A1 MIR145 MIR143 MIR10B MIR100
2 miRNA-mediated gene silencing by inhibition of translation GO:0035278 9.5 MIR145 MIR10B MIR100
3 regulation of smooth muscle contraction GO:0006940 9.4 MIR145 MIR143
4 angiotensin-activated signaling pathway GO:0038166 9.37 MIR145 MIR143
5 aorta smooth muscle tissue morphogenesis GO:0060414 9.26 MIR145 MIR143
6 regulation of phenotypic switching GO:1900239 8.96 MIR145 MIR143
7 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 8.62 MIR145 MIR143

Molecular functions related to Cervix Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.35 MIR199A1 MIR145 MIR143 MIR10B MIR100
2 mRNA base-pairing translational repressor activity GO:1903231 9.1 MIRLET7C MIR199A1 MIR145 MIR143 MIR10B MIR100

Sources for Cervix Small Cell Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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