MCID: CRV002
MIFTS: 43

Cervix Uteri Carcinoma in Situ

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Cervix Uteri Carcinoma in Situ

MalaCards integrated aliases for Cervix Uteri Carcinoma in Situ:

Name: Cervix Uteri Carcinoma in Situ 12 15
Carcinoma in Situ of Uterine Cervix 12 73
Cervical Intraepithelial Neoplasia 44 73
Cervical Intraepithelial Neoplasia Grade Iii with Severe Dysplasia 12
Cervix Intraepithelial Neoplasia Grade 3 Ajcc V7 73
Squamous Intraepithelial Neoplasia, Grade Iii 12
Cin Iii - Carcinoma in Situ of Cervix 12
Severe Dysplasia of the Cervix Uteri 12
Cin Iii - Severe Dyskaryosis 12
Carcinoma in Situ of Cervix 12
Carcinoma of Cervix Stage 0 12
Severe Dysplasia of Cervix 12
Cervix Ca in Situ 12
Cin Iii 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8991
ICD10 33 D06 D06.9
ICD9CM 35 233.1
MeSH 44 D018290
NCIt 50 C4000

Summaries for Cervix Uteri Carcinoma in Situ

Disease Ontology : 12 An in situ carcinoma that is located in the uterine cervix.

MalaCards based summary : Cervix Uteri Carcinoma in Situ, also known as carcinoma in situ of uterine cervix, is related to cervical intraepithelial neoplasia and cervicitis. An important gene associated with Cervix Uteri Carcinoma in Situ is SERPIND1 (Serpin Family D Member 1), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Oncogene Induced Senescence. The drugs Cervarix and Gardasil have been mentioned in the context of this disorder. Affiliated tissues include cervix, testes and liver, and related phenotype is mortality/aging.

Related Diseases for Cervix Uteri Carcinoma in Situ

Diseases related to Cervix Uteri Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 cervical intraepithelial neoplasia 30.9 CDKN2A KRT17
2 cervicitis 30.8 CDKN2A SERPIND1
3 anogenital venereal wart 30.7 CDKN2A GP6 TP53
4 squamous cell papilloma 30.5 CDKN2A TP53
5 in situ carcinoma 30.5 CDKN2A KRT17 SERPIND1 TP53
6 cervix carcinoma 30.3 CDKN2A TP53
7 chronic cervicitis 30.3 GP6 SERPIND1
8 suppressor of tumorigenicity 3 30.2 CDKN2A TP53
9 papilloma 10.6
10 adenocarcinoma 10.4
11 cervical squamous cell carcinoma 10.4
12 adenocarcinoma in situ 10.4
13 viral infectious disease 10.4
14 chlamydia 10.3
15 bacterial vaginosis 10.3
16 human immunodeficiency virus infectious disease 10.3
17 cervical cancer 10.3
18 balanoposthitis 10.2 CDKN2A GP6
19 retinoblastoma 10.2
20 bladder squamous cell carcinoma 10.2 CDKN2A TP53
21 keratinizing squamous cell carcinoma 10.2 CDKN2A TP53
22 spitz nevus 10.2 CDKN2A TP53
23 bladder carcinoma in situ 10.2 CDKN2A TP53
24 scrotal carcinoma 10.2 CDKN2A TP53
25 nasal cavity adenocarcinoma 10.2 CDKN2A TP53
26 bartholin's gland disease 10.2 CDKN2A TP53
27 anal squamous cell carcinoma 10.2 CDKN2A TP53
28 megaesophagus 10.2 CDKN2A TP53
29 glycogen-rich clear cell breast carcinoma 10.2 CDKN2A TP53
30 gastric adenosquamous carcinoma 10.2 CDKN2A TP53
31 oral leukoplakia 10.2 CDKN2A TP53
32 meningeal melanomatosis 10.2 CDKN2A TP53
33 dedifferentiated liposarcoma 10.2 CDKN2A TP53
34 endocervical adenocarcinoma 10.2 CDKN2A TP53
35 cervix small cell carcinoma 10.2 CDKN2A TP53
36 necrotizing sialometaplasia 10.2 CDKN2A TP53
37 verrucous carcinoma 10.2 CDKN2A TP53
38 tongue disease 10.2 CDKN2A TP53
39 biliary tract neoplasm 10.2 CDKN2A TP53
40 optic nerve neoplasm 10.2 CDKN2A TP53
41 juvenile pilocytic astrocytoma 10.2 CDKN2A TP53
42 tonsil cancer 10.2 CDKN2A TP53
43 eccrine sweat gland neoplasm 10.2 KRT17 TP53
44 recessive dystrophic epidermolysis bullosa 10.1 CDKN2A TP53
45 cervical adenosarcoma 10.1 GP5 GP6
46 vulva cancer 10.1 CDKN2A TP53
47 barrett's adenocarcinoma 10.1 CDKN2A TP53
48 ampulla of vater cancer 10.1 KRT17 TP53
49 herpangina 10.1 GP5 GP6
50 oropharynx cancer 10.1 CDKN2A TP53

Comorbidity relations with Cervix Uteri Carcinoma in Situ via Phenotypic Disease Network (PDN):


Myofibroma

Graphical network of the top 20 diseases related to Cervix Uteri Carcinoma in Situ:



Diseases related to Cervix Uteri Carcinoma in Situ

Symptoms & Phenotypes for Cervix Uteri Carcinoma in Situ

MGI Mouse Phenotypes related to Cervix Uteri Carcinoma in Situ:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.28 CDKN2A CINP COL27A1 GP6 INSM1 KLHL40

Drugs & Therapeutics for Cervix Uteri Carcinoma in Situ

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Cervarix 18 49 Human Papillomavirus Bivalent (Types 16 and 18) Vaccine, Recombinant GlaxoSmithKline October 2009
2
Gardasil 18 49 quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine Merck June 2006

Search Clinical Trials , NIH Clinical Center for Cervix Uteri Carcinoma in Situ

Cochrane evidence based reviews: cervical intraepithelial neoplasia

Genetic Tests for Cervix Uteri Carcinoma in Situ

Anatomical Context for Cervix Uteri Carcinoma in Situ

MalaCards organs/tissues related to Cervix Uteri Carcinoma in Situ:

41
Cervix, Testes, Liver, Bone, Lung, Breast, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Cervix Uteri Carcinoma in Situ:

19
The Uterine Cervix

Publications for Cervix Uteri Carcinoma in Situ

Articles related to Cervix Uteri Carcinoma in Situ:

# Title Authors Year
1
Koilocytosis preceding squamous cell carcinoma in situ of uterine cervix. ( 3028122 )
1987
2
LYMPHATIC SPREAD OF CARCINOMA-IN-SITU OF UTERINE CERVIX. ( 14087268 )
1963
3
Carcinoma in situ of uterine cervix. ( 13594660 )
1958
4
Carcinoma in situ of uterine cervix. ( 13594664 )
1958

Variations for Cervix Uteri Carcinoma in Situ

Expression for Cervix Uteri Carcinoma in Situ

Search GEO for disease gene expression data for Cervix Uteri Carcinoma in Situ.

Pathways for Cervix Uteri Carcinoma in Situ

GO Terms for Cervix Uteri Carcinoma in Situ

Biological processes related to Cervix Uteri Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell cycle GO:0007049 9.62 CDKN2A CINP INSM1 TP53
2 blood coagulation GO:0007596 9.43 GP5 GP6 SERPIND1
3 positive regulation of cell cycle arrest GO:0071158 9.16 INSM1 TP53
4 replicative senescence GO:0090399 8.96 CDKN2A TP53
5 hemostasis GO:0007599 8.8 GP5 GP6 SERPIND1

Molecular functions related to Cervix Uteri Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.62 CDKN2A TP53

Sources for Cervix Uteri Carcinoma in Situ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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