MCID: CHN002
MIFTS: 37

Chancroid

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Chancroid

MalaCards integrated aliases for Chancroid:

Name: Chancroid 12 76 53 55 44 15
Ulcus Molle, Skin 12
Chancroids 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13778
ICD10 33 A57
ICD9CM 35 099.0
MeSH 44 D002602
SNOMED-CT 68 87429008
UMLS 73 C0007947

Summaries for Chancroid

NIH Rare Diseases : 53 Chancroid is a bacterial infection that is spread through sexual contact. It is caused by a type of bacteria called Haemophilus ducreyi. Chancroid is characterized by a small bump on the genital which becomes a painful ulcer. Men may have just one ulcer, but women often develop four or more. About half of the people who are infected with a chancroid will develop enlarged inguinal lymph nodes, the nodes located in the fold between the leg and the lower abdomen. In some cases, the nodes will break through the skin and cause draining abscesses. The swollen lymph nodes and abscesses are often called buboes. Chancroid infections can be treated with antibiotics, including azithromycin, ceftriaxone, ciprofloxacin, and erythromycin. Large lymph node swellings need to be drained, either with a needle or local surgery.

MalaCards based summary : Chancroid, also known as ulcus molle, skin, is related to lymphogranuloma venereum and granuloma inguinale. An important gene associated with Chancroid is CD36 (CD36 Molecule), and among its related pathways/superpathways are Microglia Activation During Neuroinflammation: Overview and Primary Focal Segmental Glomerulosclerosis FSGS. The drugs Azithromycin and Penicillin G have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and testes.

Disease Ontology : 12 A primary bacterial infectious disease that is a sexually transmitted infection located in skin of the genitals, has material basis in Haemophilus ducreyi, which is transmitted by sexual contact. The infection has symptom painful and soft ulcers.

Wikipedia : 76 Chancroid (/�?�?æ�?kr�?ɪd/ SHANG-kroyd) (also known as soft chancre and ulcus molle) is a bacterial... more...

Related Diseases for Chancroid

Diseases related to Chancroid via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
# Related Disease Score Top Affiliating Genes
1 lymphogranuloma venereum 10.6
2 granuloma inguinale 10.6
3 syphilis 10.4
4 genital herpes 10.2
5 viral infectious disease 10.2
6 herpes simplex 10.1
7 sennetsu fever 10.0 HSPD1 HSPE1
8 thrombasthenia 10.0 CD36 VTN
9 bartonellosis 10.0 HSPD1 HSPE1
10 human immunodeficiency virus type 1 10.0
11 neutropenia 10.0
12 bacterial vaginosis 10.0
13 primary syphilis 10.0
14 molluscum contagiosum 10.0
15 leukodystrophy, hypomyelinating, 4 10.0 HSPD1 HSPE1
16 carrion's disease 9.9 HSPD1 HSPE1
17 testicular disease 9.9 HSPD1 HSPE1
18 mycobacterium gordonae 9.9 DLAT HSPD1
19 leprosy 3 9.9 HSPD1 HSPE1
20 mycobacterium tuberculosis 1 9.8 HSPD1 HSPE1

Graphical network of the top 20 diseases related to Chancroid:



Diseases related to Chancroid

Symptoms & Phenotypes for Chancroid

Drugs & Therapeutics for Chancroid

Drugs for Chancroid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 3 83905-01-5 55185 447043
2
Penicillin G Approved, Vet_approved Phase 3 61-33-6 5904
3 Anti-Bacterial Agents Phase 3
4 Dermatologic Agents Phase 3
5 Penicillin G Procaine Phase 3
6 Antibiotics, Antitubercular Phase 3
7 Penicillin G Benzathine Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of WHO-yaws Elimination Strategy in Lihir Island, Papua New Guinea Completed NCT01955252 Phase 3 Azithromycin
2 Male Circumcision for HIV Prevention in Rakai, Uganda Completed NCT00425984 Phase 3

Search NIH Clinical Center for Chancroid

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: chancroid

Genetic Tests for Chancroid

Anatomical Context for Chancroid

MalaCards organs/tissues related to Chancroid:

41
Skin, Lymph Node, Testes, Cervix

Publications for Chancroid

Articles related to Chancroid:

(show top 50) (show all 281)
# Title Authors Year
1
Putative vaccine candidates and drug targets identified by reverse vaccinology and subtractive genomics approaches to control <i>Haemophilus ducreyi</i>, the causative agent of chancroid. ( 29792307 )
2018
2
First reported case of chancroid in the Czech Republic. ( 29749871 )
2018
3
2017 European guideline for the management of chancroid. ( 28081686 )
2017
4
Other sexually transmitted diseases chancroid and donovanosis. ( 27107782 )
2016
5
First case of chancroid in 14 years at the largest STI clinic in Paris, France. ( 26378189 )
2015
6
Chancroid, lymphogranuloma venereum, granuloma inguinale, genital herpes simplex infection, and molluscum contagiosum. ( 24559566 )
2014
7
UK National Guideline for the management of chancroid 2014. ( 25080286 )
2014
8
Virtual screening of phytochemicals to novel targets in Haemophilus ducreyi towards the treatment of Chancroid. ( 25258485 )
2014
9
The Haemophilus ducreyi trimeric autotransporter adhesin DsrA protects against an experimental infection in the swine model of chancroid. ( 24844153 )
2014
10
Chancroid - desperate patient makes own diagnosis. ( 24535694 )
2014
11
Oral immunization using HgbA in a recombinant chancroid vaccine delivered by attenuated Salmonella typhimurium SL3261 in the temperature-dependent rabbit model. ( 22100216 )
2012
12
Etiologic pattern of genital ulcers in Lusaka, Zambia: has chancroid been eliminated? ( 23001266 )
2012
13
Chancroid in an HIV-negative woman in the Midwestern United States. ( 19926434 )
2011
14
Chancroid transmission dynamics: a mathematical modeling approach. ( 21842439 )
2011
15
European guideline for the management of chancroid, 2011. ( 21571970 )
2011
16
Passive immunization with a polyclonal antiserum to the hemoglobin receptor of Haemophilus ducreyi confers protection against a homologous challenge in the experimental swine model of chancroid. ( 21646451 )
2011
17
A comparative study of single-dose treatment of chancroid using thiamphenicol versus Azithromycin. ( 20191200 )
2009
18
Chancroid and human immunodeficiency virus infection--a review. ( 18173591 )
2008
19
Cutaneous chancroid in a visitor from Vanuatu. ( 18412810 )
2008
20
Expression of Haemophilus ducreyi collagen binding outer membrane protein NcaA is required for virulence in swine and human challenge models of chancroid. ( 16622201 )
2006
21
Chancroid. ( 17151046 )
2006
22
Immunization with the Haemophilus ducreyi hemoglobin receptor HgbA protects against infection in the swine model of chancroid. ( 16552053 )
2006
23
Co-occurrence of chancroid and gonorrhea. ( 17241572 )
2006
24
Male circumcision and risk of syphilis, chancroid, and genital herpes: a systematic review and meta-analysis. ( 16581731 )
2006
25
Treatment of chancroid in resource-poor countries. ( 15918786 )
2005
26
The cytolethal distending toxin of Haemophilus ducreyi aggravates dermal lesions in a rabbit model of chancroid. ( 15876546 )
2005
27
Diagnosis and Management of Chancroid in Nigeria. ( 27528984 )
2004
28
Chancroid: contemporary appraisal. ( 12653911 )
2003
29
Incidence determinants of gonorrhea, chlamydial genital infection, syphilis and chancroid in attendees at a sexually transmitted disease clinic in Athens, Greece. ( 14636203 )
2003
30
Chancroid: clinical manifestations, diagnosis, and management. ( 12576620 )
2003
31
Specificity of antibodies directed against the cytolethal distending toxin of Haemophilus ducreyi in patients with chancroid. ( 12927521 )
2003
32
Immunopathogenesis of Haemophilus ducreyi infection (chancroid). ( 11895928 )
2002
33
Chancroid: an update. ( 17656857 )
2002
34
Erythema nodosum induced by chancroid. ( 12407252 )
2002
35
Eradicating chancroid. ( 11584729 )
2001
36
Chancroid. ( 28615569 )
2001
37
Thiamphenicol in the treatment of chancroid. A study of 1,128 cases. ( 10887371 )
2000
38
Diagnostic tests for chancroid. ( 10858718 )
2000
39
Update on the experimental human model for chancroid infection. ( 10667906 )
2000
40
Chancroid in the United Kingdom. ( 10858704 )
2000
41
Chancroid: from clinical practice to basic science. ( 12240879 )
2000
42
National guideline for the management of chancroid. Clinical Effectiveness Group (Association of Genitourinary Medicine and the Medical Society for the Study of Venereal Diseases). ( 10616383 )
1999
43
The cytolethal distending toxin from the chancroid bacterium Haemophilus ducreyi induces cell-cycle arrest in the G2 phase. ( 9884340 )
1999
44
Immune cells are required for cutaneous ulceration in a swine model of chancroid. ( 10456960 )
1999
45
Neutropenia restores virulence to an attenuated Cu,Zn superoxide dismutase-deficient Haemophilus ducreyi strain in the swine model of chancroid. ( 10496915 )
1999
46
A randomized, double-blind, placebo-controlled trial of single-dose ciprofloxacin versus erythromycin for the treatment of chancroid in Nairobi, Kenya. ( 10558945 )
1999
47
Treatment of chancroid, 1997. ( 10028106 )
1999
48
Chancroid, primary syphilis, genital herpes, and lymphogranuloma venereum in Antananarivo, Madagascar. ( 10479178 )
1999
49
The use of experimental animal and human models in the study of chancroid pathogenesis. ( 10215110 )
1999
50
A comparative study of therapeutic response of patients with clinical chancroid to ciprofloxacin, erythromycin, and cotrimoxazole. ( 9662762 )
1998

Variations for Chancroid

Expression for Chancroid

Search GEO for disease gene expression data for Chancroid.

Pathways for Chancroid

Pathways related to Chancroid according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.06 CD36 HSPD1
2 10.49 VTN WT1

GO Terms for Chancroid

Cellular components related to Chancroid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial matrix GO:0005759 8.8 DLAT HSPD1 HSPE1

Biological processes related to Chancroid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.37 CD36 VTN
2 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.32 HSPD1 HSPE1
3 response to unfolded protein GO:0006986 9.26 HSPD1 HSPE1
4 positive regulation of interleukin-6 production GO:0032755 9.16 CD36 HSPD1
5 MyD88-dependent toll-like receptor signaling pathway GO:0002755 8.96 CD36 HSPD1
6 positive regulation of interleukin-12 production GO:0032735 8.62 CD36 HSPD1

Molecular functions related to Chancroid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA binding GO:0003723 9.56 HSPD1 HSPE1 RPL31 WT1
2 unfolded protein binding GO:0051082 9.32 HSPD1 HSPE1
3 chaperone binding GO:0051087 9.16 HSPD1 HSPE1
4 scavenger receptor activity GO:0005044 8.96 CD36 VTN
5 high-density lipoprotein particle binding GO:0008035 8.62 CD36 HSPD1

Sources for Chancroid

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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