MCID: CHN002
MIFTS: 40

Chancroid

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Chancroid

MalaCards integrated aliases for Chancroid:

Name: Chancroid 12 74 52 54 43 15 32
Ulcus Molle, Skin 12
Chancroids 71

Classifications:



External Ids:

Disease Ontology 12 DOID:13778
ICD9CM 34 099.0
MeSH 43 D002602
SNOMED-CT 67 266143009
ICD10 32 A57
UMLS 71 C0007947

Summaries for Chancroid

NIH Rare Diseases : 52 Chancroid is a bacterial infection that is spread through sexual contact. It is caused by a type of bacteria called Haemophilus ducreyi . Chancroid is characterized by a small bump on the genital which becomes a painful ulcer. Men may have just one ulcer, but women often develop four or more. About half of the people who are infected with a chancroid will develop enlarged inguinal lymph nodes , the nodes located in the fold between the leg and the lower abdomen. In some cases, the nodes will break through the skin and cause draining abscesses . The swollen lymph nodes and abscesses are often called buboes. Chancroid infections can be treated with antibiotics , including azithromycin , ceftriaxone , ciprofloxacin , and erythromycin . Large lymph node swellings need to be drained, either with a needle or local surgery.

MalaCards based summary : Chancroid, also known as ulcus molle, skin, is related to syphilis and primary syphilis. An important gene associated with Chancroid is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Integrin Pathway and Akt Signaling. The drugs Acyclovir and Antiviral Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and testes, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A primary bacterial infectious disease that is a sexually transmitted infection located in skin of the genitals, has material basis in Haemophilus ducreyi, which is transmitted by sexual contact. The infection has symptom painful and soft ulcers.

Wikipedia : 74 Chancroid (/ˈʃæŋkrɔɪd/ SHANG-kroyd) is a bacterial sexually transmitted infection characterized by... more...

Related Diseases for Chancroid

Diseases related to Chancroid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 258)
# Related Disease Score Top Affiliating Genes
1 syphilis 30.6 CD40LG CD4 CCR6 CCR5
2 primary syphilis 30.3 WT1 CD40LG CD4
3 genital herpes 30.2 CD40LG CD4 CCR6 CCR5
4 fungal infectious disease 29.9 CD40LG CD4 CCR6
5 bacterial infectious disease 29.8 HSPD1 CD40LG CD4 CCR6
6 immune deficiency disease 29.1 CD40LG CD4 CCR8 CCR6 CCR5
7 lymphogranuloma venereum 10.7
8 granuloma inguinale 10.7
9 herpes simplex 10.6
10 chronic graft versus host disease 10.5 CD4 CD36
11 anti-basement membrane glomerulonephritis 10.4 CD4 CCR6
12 mycobacterium gordonae 10.4 HSPD1 DLAT
13 esophageal candidiasis 10.4 CD4 CCR6
14 farmer's lung 10.4 CD4 CD36
15 pneumonic tularemia 10.4 CD4 CCR6
16 human immunodeficiency virus type 1 10.4
17 chlamydia 10.4
18 subcutaneous mycosis 10.4 CD4 CCR6
19 nocardiosis 10.4 HSPD1 CD4
20 dacryoadenitis 10.4 CD4 CCR6
21 inflammatory bowel disease 23 10.4 CCR6 CCL27
22 glanders 10.4 HSPD1 CD4
23 lymphadenitis 10.4
24 human monocytic ehrlichiosis 10.4 HSPD1 CD4
25 abacavir allergy 10.3 CD4 CCR5
26 autoimmune vasculitis 10.3 CD4 CCR6
27 haemophilus influenzae 10.3
28 hyper ige recurrent infection syndrome 1 10.2 CD4 CCR6
29 egg allergy 10.2 CD4 CCR6
30 whipple disease 10.2 HSPD1 CD4
31 tick infestation 10.2 HSPD1 CD4
32 vaginal disease 10.2 CD4 CCR6 CCR5
33 anus disease 10.2 CD4 CCR6 CCR5
34 vulvovaginitis 10.2 HSPD1 CCR6
35 reactive arthritis 10.1 HSPD1 CCR6 CCR5
36 allergic contact dermatitis 10.1 CD4 CCR10 CCL27
37 contact dermatitis 10.1 CD4 CCR10 CCL27
38 cork-handlers' disease 10.1 CD40LG CD4
39 alcohol dependence 10.1
40 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
41 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.1
42 neutropenia 10.1
43 bacterial vaginosis 10.1
44 paraphimosis 10.1
45 periodontitis 10.1
46 vasculitis 10.1
47 molluscum contagiosum 10.1
48 lipogranulomatosis 10.1
49 american histoplasmosis 10.1 CD40LG CD4
50 syphilitic meningitis 10.1 CD40LG CD4

Graphical network of the top 20 diseases related to Chancroid:



Diseases related to Chancroid

Symptoms & Phenotypes for Chancroid

MGI Mouse Phenotypes related to Chancroid:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 CCR10 CCR5 CCR6 CD36 CD4 CD40LG
2 immune system MP:0005387 9.32 ACKR2 CCR10 CCR5 CCR6 CCR8 CD36

Drugs & Therapeutics for Chancroid

Drugs for Chancroid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acyclovir Approved Phase 2, Phase 3 59277-89-3 2022
2 Antiviral Agents Phase 2, Phase 3
3 Anti-Infective Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Impact of Episodic Acyclovir Therapy on Ulcer Duration and HIV Shedding From Genital Ulcers Among Men in South Africa Completed NCT00164424 Phase 2, Phase 3 Acyclovir
2 Anti-Herpetic Treatment Associated With Syndromic Management of Genital Ulcer in Africa: Clinical and Biological Evaluation on HIV-1 and HSV-2 Shedding (ANRS 1212) Completed NCT00158483 Phase 2 Acyclovir (ACV)

Search NIH Clinical Center for Chancroid

Inferred drug relations via UMLS 71 / NDF-RT 50 :


ERYTHROMYCIN PWDR

Cochrane evidence based reviews: chancroid

Genetic Tests for Chancroid

Anatomical Context for Chancroid

MalaCards organs/tissues related to Chancroid:

40
Skin, Lymph Node, Testes, T Cells, Cervix, Endothelial, Neutrophil

Publications for Chancroid

Articles related to Chancroid:

(show top 50) (show all 811)
# Title Authors PMID Year
1
Characterization of Haemophilus ducreyi cdtA, cdtB, and cdtC mutants in in vitro and in vivo systems. 54 61
11500438 2001
2
Unilateral inguinal lymphadenitis caused by Yersinia pseudotuberculosis. A case report. 61
32386928 2020
3
Genital Ulcers: Differential Diagnosis and Management. 61
32163252 2020
4
Rollet's mixed chancre in Brazilian pregnant women: An unusual case report. 61
31743797 2020
5
A Young Patient with Painful Penile Lesions. 61
31886100 2019
6
Genital Ulcer Disease: A Review of Pathogenesis and Clinical Features. 61
31253050 2019
7
Nonviral Sexually Transmitted Diseases. 61
31507345 2019
8
A Class I Haemophilus ducreyi Strain Containing a Class II hgbA Allele Is Partially Attenuated in Humans: Implications for HgbA Vaccine Efficacy Trials. 61
31036601 2019
9
Determination of an Interaction Network between an Extracellular Bacterial Pathogen and the Human Host. 61
31213562 2019
10
Common Bacterial and Viral Infections: Review of Management in the Pregnant Patient. 61
30556401 2019
11
[Lentigines]. 61
31692707 2019
12
[Chancroid]. 61
31565145 2019
13
[Sexually Transmitted Infections in the Tropics]. 61
30324430 2018
14
First reported case of chancroid in the Czech Republic. 61
29749871 2018
15
Disease Pattern among Sexually Transmitted Infection Clinic Attendees: A Hospital-Based Study. 61
30504980 2018
16
From in vivo to in vitro: How the Guatemala STD Experiments Transformed Bodies Into Biospecimens. 61
29652094 2018
17
Putative vaccine candidates and drug targets identified by reverse vaccinology and subtractive genomics approaches to control Haemophilus ducreyi, the causative agent of chancroid. 61
29792307 2018
18
Direct Whole-Genome Sequencing of Cutaneous Strains of Haemophilus ducreyi. 61
29553314 2018
19
The Etiology of Genital Ulcer Disease and Coinfections With Chlamydia trachomatis and Neisseria gonorrhoeae in Zimbabwe: Results From the Zimbabwe STI Etiology Study. 61
29240636 2018
20
Despite Being "Known, Highly Promiscuous and Active": Presumed Heterosexuality in the USPHS's STD Inoculation Study, 1946-48. 61
30274528 2018
21
Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults. 61
29226307 2017
22
Usefulness and Utility of NACO Regime in the Management of Sexually Transmitted Infections: A Pilot Study. 61
29263538 2017
23
Skin diseases of the vulva: Infectious diseases. 61
28397528 2017
24
Sexually Transmitted Infections in Melbourne, Australia from 1918 to 2016: nearly a century of data. 61
29720070 2017
25
Pseudoepitheliomatous hyperplasia causing a painful plaque in a HIV-infected female. 61
28470128 2017
26
2017 European guideline for the management of chancroid. 61
28081686 2017
27
Gonorrhoea in Greenland, incidence and previous preventive measures: a review to improve future strategies. 61
28745556 2017
28
Haemophilus ducreyi Cutaneous Ulcer Strains Diverged from Both Class I and Class II Genital Ulcer Strains: Implications for Epidemiological Studies. 61
28027326 2016
29
Sexually Transmitted Infections Among Hospitalized Patients With Human Immunodeficiency Virus Infection and Acquired Immune Deficiency Syndrome (HIV/AIDS) in Zahedan, Southeastern Iran. 61
27818966 2016
30
Sexually transmitted infections case notification rates in the Kingdom of Saudi Arabia, 2005-2012. 61
27580336 2016
31
Other sexually transmitted diseases chancroid and donovanosis. 61
27107782 2016
32
First case of chancroid in 14 years at the largest STI clinic in Paris, France. 61
26378189 2016
33
Complete Genome Sequences of 11 Haemophilus ducreyi Isolates from Children with Cutaneous Lesions in Vanuatu and Ghana. 61
27389258 2016
34
Haemophilus ducreyi Seeks Alternative Carbon Sources and Adapts to Nutrient Stress and Anaerobiosis during Experimental Infection of Human Volunteers. 61
26930707 2016
35
Haemophilus ducreyi: from sexually transmitted infection to skin ulcer pathogen. 61
26658654 2016
36
Prevalence of Sexually Transmitted Infection in Teenage Pregnancy in Rajavithi Hospital, Thailand. 61
27266230 2016
37
Medical Examination of Aliens--Revisions to Medical Screening Process. Final rule. 61
26812891 2016
38
Defining Potential Vaccine Targets of Haemophilus ducreyi Trimeric Autotransporter Adhesin DsrA. 61
25897604 2015
39
A case of syphilitic anal condylomata lata mimicking malignancy. 61
26555060 2015
40
[Male circumcision from an infectiological point of view]. 61
25492382 2015
41
Travel-related sexually transmitted infections. 61
26726895 2015
42
Molecular phylogenetic analysis of non-sexually transmitted strains of Haemophilus ducreyi. 61
25774793 2015
43
Pattern of sexually transmitted infections in a Muslim majority region of North India. 61
26392651 2015
44
Male Circumcision and STI Acquisition in Britain: Evidence from a National Probability Sample Survey. 61
26083250 2015
45
UK National Guideline for the management of Chancroid 2014. 61
25080286 2014
46
Haemophilus ducreyi RpoE and CpxRA appear to play distinct yet complementary roles in regulation of envelope-related functions. 61
25201944 2014
47
Syphilis and human experimentation from World War II to the present: a historical perspective and reflections on ethics. 61
24461955 2014
48
Pattern of sexually transmitted diseases in patients presenting at Ayub teaching hospital, Abbottabad. 61
25672192 2014
49
Chancroid - desperate patient makes own diagnosis. 61
24535694 2014
50
A (p)ppGpp-null mutant of Haemophilus ducreyi is partially attenuated in humans due to multiple conflicting phenotypes. 61
24914217 2014

Variations for Chancroid

Expression for Chancroid

Search GEO for disease gene expression data for Chancroid.

Pathways for Chancroid

Pathways related to Chancroid according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 VTN CD36 CCR8 CCR6 CCR5 CCR10
2
Show member pathways
12.95 CD40LG CD4 CCR8 CCR6 CCR5 CCR10
3
Show member pathways
12.77 CD40LG CD4 CCR8 CCR6 CCR5 CCR10
4
Show member pathways
12.19 CD4 CCR8 CCR6 CCR5 CCR10 CCL27
5
Show member pathways
11.43 CCR8 CCR6 CCR5 CCR10 CCL27 ACKR2

GO Terms for Chancroid

Cellular components related to Chancroid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.8 CD4 CD36 CCR8 CCR6 CCR5 CCR10
2 integral component of plasma membrane GO:0005887 9.76 CD40LG CD4 CD36 CCR8 CCR6 CCR5
3 cell surface GO:0009986 9.5 HSPD1 CD40LG CD4 CD36 CCR6 CCR5
4 external side of plasma membrane GO:0009897 9.23 CD40LG CD4 CD36 CCR8 CCR6 CCR5

Biological processes related to Chancroid according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.05 CD40LG CD4 CCR8 CCR6 CCR5 CCR10
2 G protein-coupled receptor signaling pathway GO:0007186 9.95 CCR8 CCR6 CCR5 CCR10 CCL27 ACKR2
3 calcium-mediated signaling GO:0019722 9.77 CCR8 CCR6 CCR5 CCR10 ACKR2
4 chemotaxis GO:0006935 9.73 CCR8 CCR6 CCR5 CCR10 CCL27 ACKR2
5 chemokine-mediated signaling pathway GO:0070098 9.72 CCR8 CCR6 CCR5 CCR10 ACKR2
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.63 VTN CD4 CD36
7 positive regulation of cytosolic calcium ion concentration GO:0007204 9.63 CD36 CCR8 CCR6 CCR5 CCR10 ACKR2
8 positive regulation of interleukin-12 production GO:0032735 9.58 HSPD1 CD40LG CD36
9 dendritic cell chemotaxis GO:0002407 9.49 CCR6 CCR5
10 fusion of virus membrane with host plasma membrane GO:0019064 9.43 CD4 CCR5
11 cell chemotaxis GO:0060326 9.43 CCR8 CCR6 CCR5 CCR10 CCL27 ACKR2
12 immune response GO:0006955 9.32 VTN CD40LG CD4 CD36 CCR8 CCR6

Molecular functions related to Chancroid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine binding GO:0019956 9.65 CCR8 CCR6 CCR5 CCR10 ACKR2
2 C-C chemokine binding GO:0019957 9.55 CCR8 CCR6 CCR5 CCR10 ACKR2
3 scavenger receptor activity GO:0005044 9.54 VTN CD36 ACKR2
4 coreceptor activity GO:0015026 9.5 CD4 CCR8 CCR5
5 high-density lipoprotein particle binding GO:0008035 9.4 HSPD1 CD36
6 C-C chemokine receptor activity GO:0016493 9.35 CCR8 CCR6 CCR5 CCR10 ACKR2
7 chemokine receptor activity GO:0004950 9.02 CCR8 CCR6 CCR5 CCR10 ACKR2

Sources for Chancroid

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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