MCID: CHL056
MIFTS: 47

Cheilitis

Categories: Gastrointestinal diseases, Oral diseases, Skin diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Cheilitis

Summaries for Cheilitis

Disease Ontology: 11 A lip disease characterized by the inflammation of the lips; which may include the perioral skin, the vermilion border and the labial mucosa.

MalaCards based summary: Cheilitis is related to actinic keratosis and lichen planus. An important gene associated with Cheilitis is CAST (Calpastatin), and among its related pathways/superpathways are Innate Immune System and Signal Transduction. The drugs Imiquimod and Aminolevulinic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, salivary gland and lymph node, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia: 75 Cheilitis is a medical condition characterized by inflammation of the lips. The inflammation may include... more...

Related Diseases for Cheilitis

Diseases related to Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 412)
# Related Disease Score Top Affiliating Genes
1 actinic keratosis 30.9 TP53 TNF BCL2
2 lichen planus 30.7 TP53 TNF CD1A
3 keratosis 30.7 TP53 MMP9 FGFR3 BCL2
4 squamous cell carcinoma, head and neck 30.3 TP53 STAT3 MMP9 FGFR3 CSF2 CDKN1A
5 histiocytosis 30.2 TNF CSF2 CD1A
6 squamous cell carcinoma 30.2 TP53 STAT3 MMP9 MDM2 FGFR3 CDKN1A
7 leprosy 3 30.2 TNF CSF2 CD1A
8 exanthem 30.0 TNF PDCD1 CSF2 CD274
9 severe cutaneous adverse reaction 29.9 TNF PDCD1 CD274
10 suppressor of tumorigenicity 3 29.9 TP53 CDKN1A BCL2
11 anus disease 29.9 TP53 TNF CD274
12 fungal infectious disease 29.8 TNF STAT3 CSF2
13 skin benign neoplasm 29.8 TP53 STAT3 MSH2 FGFR3
14 skin carcinoma 29.8 TP53 TNF PDCD1 MSH2 CD274 BCL2
15 acquired immunodeficiency syndrome 29.7 TP53 TNF CSF2 BCL2
16 vitiligo-associated multiple autoimmune disease susceptibility 1 29.7 TNF PDCD1 CD274
17 lymphoid interstitial pneumonia 29.7 TNF STAT3 CSF2 CD1A
18 lymphangioma 29.5 TP53 TNF STAT3 MSH2 BCL2
19 lymphoma, hodgkin, classic 29.5 TP53 STAT3 MDM2 CSF2 BCL2
20 aplastic anemia 29.5 TP53 TNF MSH2 ERCC1 CSF2
21 neutropenia 29.4 TP53 TNF ERCC1 CSF2 BCL2
22 keratoacanthoma 29.4 TP53 STAT3 MSH2 CDKN1A CD1A BCL2
23 myocarditis 29.4 TNF STAT3 MMP9 CD274 BCL2
24 acute promyelocytic leukemia 29.3 TP53 TNF STAT3 CSF2 CDKN1A BCL2
25 autoimmune disease 29.2 TNF STAT3 PDCD1 MMP9 CD274
26 systemic lupus erythematosus 29.0 TP53 TNF STAT3 PDCD1 MMP9 CSF2
27 basal cell carcinoma 29.0 TP53 TNF STAT3 MSH2 MMP9 ERCC1
28 skin disease 28.8 TP53 TNF STAT3 PDCD1 MMP9 KRT6A
29 lymphoma 28.8 TP53 STAT3 PDCD1 MDM2 MALT1 CD274
30 lymphoma, non-hodgkin, familial 28.7 TP53 STAT3 MSH2 MDM2 MALT1 CSF2
31 angular cheilitis 11.6
32 cheilitis glandularis 11.6
33 actinic cheilitis 11.6
34 peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads 11.5
35 melkersson-rosenthal syndrome 11.5
36 actinic prurigo 11.2
37 mucoepithelial dysplasia, hereditary 10.9
38 ectodermal dysplasia/skin fragility syndrome 10.9
39 immunodeficiency 12 10.9
40 factor xi deficiency 10.7
41 crohn's disease 10.6
42 bell's palsy 10.4
43 fissured tongue 10.4
44 contact dermatitis 10.3
45 esophagus verrucous carcinoma 10.3 TP53 MDM2
46 polyploidy 10.3 TP53 CDKN1A
47 facial paralysis 10.3
48 dermatitis 10.3
49 stomatitis 10.3
50 senile entropion 10.3 TNF CSF2

Graphical network of the top 20 diseases related to Cheilitis:



Diseases related to Cheilitis

Symptoms & Phenotypes for Cheilitis

GenomeRNAi Phenotypes related to Cheilitis according to GeneCards Suite gene sharing:

25 (show all 37)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-10 10.21 FGFR3
2 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.21 KRT6A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.21 KRT6A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-114 10.21 FGFR3 KRT6A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.21 MSH2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.21 FGFR3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.21 KRT6A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-14 10.21 MSH2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-145 10.21 ERCC1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.21 MSH2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-159 10.21 KRT6A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.21 ERCC1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.21 ERCC1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.21 MSH2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-18 10.21 ERCC1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-181 10.21 ERCC1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-204 10.21 ERCC1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.21 MSH2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.21 PDCD1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-33 10.21 KRT6A
21 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.21 PDCD1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.21 PDCD1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.21 FGFR3
24 Increased shRNA abundance (Z-score > 2) GR00366-A-53 10.21 MSH2
25 Increased shRNA abundance (Z-score > 2) GR00366-A-56 10.21 KRT6A
26 Increased shRNA abundance (Z-score > 2) GR00366-A-58 10.21 KRT6A
27 Increased shRNA abundance (Z-score > 2) GR00366-A-59 10.21 FGFR3 PDCD1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-60 10.21 FGFR3
29 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.21 ERCC1 FGFR3 PDCD1
30 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.21 ERCC1 FGFR3
31 Increased shRNA abundance (Z-score > 2) GR00366-A-90 10.21 KRT6A
32 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 10.18 CDKN1A PDCD1 TNF
33 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 10.18 CDKN1A ERCC1 PDCD1 TNF TP53
34 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 10.18 CDKN1A ERCC1 TP53 CEACAM3 MDM2 MSH2
35 no effect GR00402-S-1 10.17 APEX1 BCL2 CAST CD1A CD274 CDKN1A
36 no effect GR00402-S-2 10.17 APEX1 BCL2 CAST CD1A CD274 CDKN1A
37 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.56 CSF2 MSH2 PDCD1 TNF

MGI Mouse Phenotypes related to Cheilitis:

45 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.47 APEX1 BCL2 CAST CD274 CDKN1A CSF2
2 growth/size/body region MP:0005378 10.46 APEX1 BCL2 CAST CDKN1A CSF2 CTNNBIP1
3 nervous system MP:0003631 10.45 BCL2 CAST CDKN1A CSF2 CTNNBIP1 ERCC1
4 neoplasm MP:0002006 10.42 APEX1 BCL2 CDKN1A CSF2 ERCC1 FGFR3
5 cellular MP:0005384 10.4 APEX1 BCL2 CAST CD274 CDKN1A CSF2
6 renal/urinary system MP:0005367 10.34 BCL2 CDKN1A CSF2 CTNNBIP1 ERCC1 FGFR3
7 immune system MP:0005387 10.34 APEX1 BCL2 CAST CD274 CDKN1A CSF2
8 muscle MP:0005369 10.29 APEX1 BCL2 CDKN1A ERCC1 MDM2 MMP9
9 behavior/neurological MP:0005386 10.27 BCL2 CAST CD274 CDKN1A CSF2 ERCC1
10 digestive/alimentary MP:0005381 10.26 BCL2 CDKN1A CTNNBIP1 FGFR3 KRT6A MDM2
11 cardiovascular system MP:0005385 10.26 APEX1 BCL2 CAST CDKN1A CSF2 CTNNBIP1
12 endocrine/exocrine gland MP:0005379 10.25 APEX1 BCL2 CDKN1A CSF2 ERCC1 MDM2
13 embryo MP:0005380 10.24 APEX1 BCL2 CDKN1A CSF2 CTNNBIP1 ERCC1
14 craniofacial MP:0005382 10.21 BCL2 CDKN1A CSF2 CTNNBIP1 FGFR3 KRT6A
15 liver/biliary system MP:0005370 10.19 APEX1 CDKN1A ERCC1 MDM2 PDCD1 STAT3
16 adipose tissue MP:0005375 10.12 BCL2 CDKN1A CSF2 ERCC1 STAT3 TNF
17 reproductive system MP:0005389 10.11 APEX1 BCL2 CDKN1A CSF2 ERCC1 FGFR3
18 skeleton MP:0005390 10.1 CD274 CDKN1A CSF2 CTNNBIP1 ERCC1 FGFR3
19 respiratory system MP:0005388 10.06 CDKN1A CSF2 CTNNBIP1 FGFR3 MMP9 PDCD1
20 hematopoietic system MP:0005397 10.06 BCL2 CAST CD274 CDKN1A CSF2 CTNNBIP1
21 vision/eye MP:0005391 9.96 BCL2 CDKN1A CTNNBIP1 ERCC1 FGFR3 MMP9
22 mortality/aging MP:0010768 9.91 APEX1 BCL2 CAST CD274 CDKN1A CSF2
23 integument MP:0010771 9.47 BCL2 CD274 CDKN1A CSF2 ERCC1 FGFR3

Drugs & Therapeutics for Cheilitis

Drugs for Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
2
Aminolevulinic acid Approved Phase 4 106-60-5 137
3 Adjuvants, Immunologic Phase 4
4 interferons Phase 4
5 Dermatologic Agents Phase 4
6 Immunologic Factors Phase 4
7 Methyl 5-aminolevulinate Phase 4
8 Photosensitizing Agents Phase 4
9
Chitosan low molecular weight (20-200 mpa.s) Experimental Phase 1 14257-69-3, 9012-76-4 441477 71853
10 Radiation-Protective Agents Phase 1
11 Sunscreening Agents Phase 1
12 Protective Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Clinical Trial of ALA Photodynamic Therapy for Treatment of Actinic Cheilitis in Patients With Squamous Cell Carcinoma of the Lip. Completed NCT00868088 Phase 4
2 Randomized Prospective Study Comparing 5% Imiquimod and Photodynamic Therapy for Actinic Cheilitis Completed NCT00849992 Phase 4 Imiquimod 5%
3 Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis Completed NCT02409732 Phase 4 aminolevulinic acid hydrochloride
4 Trichloroacetic Acid as a Topical Treatment for Actinic Cheilitis Recruiting NCT04744103 Phase 4 TCA
5 Photodynamic Therapy With Metil 5-aminolevulinate for Actinic Cheilitis - A Phase 2 Randomized Double-blind Placebo Controlled Clinical Trial Unknown status NCT03990636 Phase 2 Metil 5-aminolevulinate
6 Phase 1/2 Clinical Trial for the Evaluation of Ingenol Mebutate for Actinic Cheilitis Withdrawn NCT03452566 Phase 1, Phase 2 Ingenol mebutate gel
7 A Randomized, Prospective Study Comparing Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Ablative Fractional Laser Treatment for Actinic Cheilitis Completed NCT02198469 Phase 1 Er:YAG AFL-PDT;MAL-PDT
8 Evaluation of Topical Application of 5% Imiquimod, 0.05% Imiquimod and 0.05% Nanoencapsulated Imiquimod Gel in the Treatment of Actinic Cheilitis: a Randomized Controlled Trial Terminated NCT04219358 Phase 1 Vehicle Gel Base;Imiquimod 5% gel;Imiquimod 0,05% gel;Imiquimod nanoencapsulated 0,05% gel;Lip sunscreen 30 Sun Protector Factor (SPF);Dexpanthenol
9 Actinic Cheilitis Pre-Treated With DNA Repair Enzyme Cream Withdrawn NCT03224715

Search NIH Clinical Center for Cheilitis

Cochrane evidence based reviews: cheilitis

Genetic Tests for Cheilitis

Genetic tests related to Cheilitis:

# Genetic test Affiliating Genes
1 Cheilitis 28

Anatomical Context for Cheilitis

Organs/tissues related to Cheilitis:

MalaCards : Skin, Salivary Gland, Lymph Node, Nk Cells, Prostate, Bone Marrow, Liver

Publications for Cheilitis

Articles related to Cheilitis:

(show top 50) (show all 1761)
# Title Authors PMID Year
1
Upgrading removable denture design by using strategic implants: A case report. 62
36183934 2023
2
Immunohistochemical comparative analysis of IMP-3 and KI-67 in actinic cheilitis and lower lip squamous cell carcinoma. 62
34817714 2022
3
Cheilitis caused by allergic contact dermatitis to cinnamon in chai tea: a case report. 62
36461791 2022
4
Correction: First isolation and identification of Cystobasidium calyptogenae from the oral samples of an elderly patient presenting with angular cheilitis. 62
36471451 2022
5
Zinc Deficiency with Cheilitis: A Report of Five Cases. 62
36420553 2022
6
Contact cheilitis due to continuous respiratory protection for COVID-19. 62
34914158 2022
7
[Translated article] Glandular Cheilitis: Rare or Underdiagnosed? 62
36206812 2022
8
[Occupational Dermatoses in Healthcare Workers during the COVID-19 Pandemic: A Narrative Review]. 62
35766244 2022
9
Combination of CO2 laser therapy and pulsed dye laser therapy for the treatment of actinic cheilitis. 62
36382418 2022
10
Dermoscopic findings in a case of plasma cell cheilitis. 62
36088186 2022
11
Glandular Cheilitis: Rare or Underdiagnosed? 62
35525279 2022
12
Sézary syndrome: Report of a rare case with perioral manifestation and review of the literature. 62
36183500 2022
13
Oral manifestations associated with inflammatory bowel disease and early endoscopic findings in patients with spondyloarthritis. 62
36348398 2022
14
Clinical predictors of malignant transformation and recurrence in oral potentially malignant disorders: A systematic review and meta-analysis. 62
36153299 2022
15
Evidence-Based Clinical Practice Guidelines for Laser-Assisted Drug Delivery. 62
35976634 2022
16
Laminin Immunostaining in Biopsies as a Useful Biomarker of Early Invasion in Actinic Cheilitis and Differential Diagnosis Between Actinic Cheilitis and Lip Cancer: New Insights. 62
36303015 2022
17
Allergic contact cheilitis in Melbourne, Australia. 62
35611494 2022
18
Lip mesotherapy with dexpanthenol in the treatment of isotretinoin-induced cheilitis. 62
35426210 2022
19
Sun protection as a protective factor for actinic cheilitis: Cross-sectional population-based study. 62
33751725 2022
20
Randomized Clinical Trial of Conventional versus Indoor Daylight Photodynamic Therapy for Treatment of Actinic Cheilitis. 62
35907163 2022
21
Atomoxetine-Associated Angular Cheilitis. 62
32235145 2022
22
Clinical predictors of metal allergic sensitization in orthodontic patients. 62
36239365 2022
23
Oral Manifestations of Systemic Lupus Erythematosus: A Systematic Review. 62
36231212 2022
24
S2k guideline: Laser therapy of the skin. 62
36098675 2022
25
Delayed onset Crohn's disease following cheilitis granulomatosa: A case report. 62
35514072 2022
26
Oral manifestations of autoimmune polyglandular syndrome type 1. 62
35182449 2022
27
The Role of Reflectance Confocal Microscopy in the Evaluation of Pigmented Oral Lesions and Their Relationship With Histopathological Aspects. 62
35503878 2022
28
[Pemphigus vulgaris clinically masquerading as cheilitis: report of two cases]. 62
36097946 2022
29
New Approach to Addison Disease: Oral Manifestations Due to Endocrine Dysfunction and Comorbidity Burden. 62
36140482 2022
30
Borderline tuberculoid leprosy misdiagnosed as Cheilitis Granulomatosa Miescher: A case report. 62
35957798 2022
31
Skin manifestations of neuroendocrine neoplasms: review of the literature. 62
36090712 2022
32
Cheilitis: A cross-sectional study-multiple factors involved in the aetiology and clinical features. 62
36001068 2022
33
Effects of Blue Light on the Skin and Its Therapeutic Uses: Photodynamic Therapy and Beyond. 62
35917260 2022
34
Concerning the assessment of outcomes in the treatment of actinic cheilitis. Comment on: "Cheilitis Actinica: topical treatment with 3.75% imiquimod". 62
35512062 2022
35
Actinic cheilitis or squamous cell carcinoma of the lip? Practical recommendations on how to avoid a trap. 62
35946758 2022
36
In vivo reflectance confocal microscopy diagnostic features of actinic cheilitis: a retrospective case series. 62
35181949 2022
37
Actinic cheilitis: Proposal of a clinical index. 62
35660729 2022
38
Cheilitis Actinica: topical treatment with 3.75% imiquimod. 62
35220604 2022
39
Current treatment modalities in granulomatous cheilitis. 62
35174873 2022
40
A case of squamous cell carcinoma arising from plasma cell cheilitis. 62
34363694 2022
41
Efficacy of photodynamic therapy in actinic cheilitis: A systematic review. 62
35218940 2022
42
Knowledge, Practice, and Awareness of Oral Cancer and HPV Infection among Dental Students and Residents: A Cross-Sectional Study. 62
35744069 2022
43
Dermoscopy in the diagnosis and assessment of treatment response in granulomatous cheilitis. 62
35750429 2022
44
[Relationship between peripheral blood micronutrients and four kinds of oral mucosal diseases in children: clinical analysis of 217 cases]. 62
36204956 2022
45
Toxicity, Genotoxicity, and Carcinogenicity of Isotretinoin: A review. 62
35619315 2022
46
Crohn's Disease Presenting as Metabolic Myopathy: A Case Report. 62
35864676 2022
47
Long COVID Oral Cavity Symptoms Based on Selected Clinical Cases. 62
34921381 2022
48
Reply to: current treatment modalities in granulomatous cheilitis. 62
35553064 2022
49
[The effect of four immunosuppressive drugs on oral manifestations after organ transplantation]. 62
36110078 2022
50
Epithelial-mesenchymal transition modulates lower lip carcinogenesis and promotes cancer progression. 62
35240445 2022

Variations for Cheilitis

Expression for Cheilitis

Search GEO for disease gene expression data for Cheilitis.

Pathways for Cheilitis

Pathways related to Cheilitis according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 TP53 TNF STAT3 PDCD1 MMP9 MALT1
2 13.73 BCL2 CD274 CDKN1A CSF2 CTNNBIP1 FGFR3
3
Show member pathways
13.63 TP53 TNF STAT3 MMP9 FGFR3 CSF2
4
Show member pathways
13.47 TP53 TNF STAT3 MDM2 MALT1 FGFR3
5
Show member pathways
13.39 TP53 TNF STAT3 MDM2 FGFR3 CSF2
6
Show member pathways
13.32 TP53 TNF STAT3 MMP9 CSF2 CDKN1A
7
Show member pathways
12.83 TP53 TNF STAT3 MMP9 CDKN1A BCL2
8
Show member pathways
12.62 TP53 STAT3 MSH2 MDM2 FGFR3 CDKN1A
9
Show member pathways
12.57 TP53 TNF STAT3 MSH2 CDKN1A BCL2
10 12.54 TNF STAT3 PDCD1 MALT1 CD274 APEX1
11
Show member pathways
12.51 TP53 MSH2 MDM2 ERCC1 CDKN1A BCL2
12 12.47 APEX1 CDKN1A ERCC1 MDM2 MSH2 TP53
13 12.47 TP53 MMP9 MDM2 FGFR3 CSF2 CDKN1A
14
Show member pathways
12.45 TP53 STAT3 MDM2 FGFR3 CDKN1A
15
Show member pathways
12.44 TP53 MDM2 FGFR3 BCL2
16
Show member pathways
12.37 TP53 TNF CDKN1A BCL2
17
Show member pathways
12.28 TNF STAT3 MMP9 CSF2
18
Show member pathways
12.22 TP53 MDM2 FGFR3 CDKN1A BCL2
19
Show member pathways
12.2 TP53 MDM2 CDKN1A BCL2
20 12.14 BCL2 MDM2 MSH2 TP53
21 12.1 CDKN1A MMP9 MSH2 STAT3 TNF TP53
22 12 TP53 MSH2 MDM2 CDKN1A BCL2
23 11.98 APEX1 MMP9 TNF TP53
24
Show member pathways
11.98 TP53 TNF PDCD1 MALT1 CSF2 CDKN1A
25 11.93 TP53 MDM2 CDKN1A BCL2
26 11.91 TP53 MDM2 CDKN1A BCL2
27 11.89 TP53 CDKN1A BCL2
28 11.88 TNF MSH2 CDKN1A
29 11.83 TP53 MDM2 CDKN1A
30
Show member pathways
11.81 TP53 MDM2 CDKN1A
31 11.8 TP53 MSH2 MDM2
32 11.77 STAT3 MMP9 BCL2
33 11.77 TP53 MDM2 CSF2 CDKN1A
34 11.76 CD1A CSF2 TNF
35 11.75 TP53 FGFR3 CDKN1A
36 11.72 TP53 MMP9 CSF2
37 11.7 TP53 MDM2 CDKN1A BCL2 APEX1
38
Show member pathways
11.68 TNF MMP9 CSF2
39 11.68 TNF MMP9 CSF2
40 11.67 TP53 TNF STAT3 MMP9 CDKN1A BCL2
41 11.61 CDKN1A CSF2 MDM2
42 11.6 TP53 STAT3 CDKN1A
43 11.59 TP53 MDM2 APEX1
44 11.59 STAT3 MMP9 FGFR3
45 11.53 STAT3 PDCD1 CD274
46 11.51 TNF STAT3 CSF2
47 11.48 TP53 MDM2 CDKN1A
48
Show member pathways
11.46 STAT3 MSH2 BCL2 APEX1
49 11.43 TNF CDKN1A BCL2

GO Terms for Cheilitis

Biological processes related to Cheilitis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 10.27 TP53 TNF MMP9 MDM2 MALT1 BCL2
2 apoptotic process GO:0006915 10.25 TP53 TNF PDCD1 MMP9 MDM2 FGFR3
3 cellular response to DNA damage stimulus GO:0006974 10.11 APEX1 BCL2 CDKN1A ERCC1 MSH2 TP53
4 positive regulation of miRNA transcription GO:1902895 10.03 TP53 TNF STAT3
5 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.97 TNF CSF2 BCL2
6 cell population proliferation GO:0008283 9.92 BCL2 CSF2 ERCC1 STAT3 TP53
7 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.91 TP53 MSH2 CDKN1A
8 cellular response to gamma radiation GO:0071480 9.88 TP53 MDM2 CDKN1A
9 B cell lineage commitment GO:0002326 9.84 TP53 BCL2
10 cellular response to actinomycin D GO:0072717 9.78 TP53 MDM2
11 response to X-ray GO:0010165 9.73 TP53 MSH2 ERCC1
12 T cell lineage commitment GO:0002360 9.72 TP53 BCL2
13 signal transduction by p53 class mediator GO:0072331 9.7 CDKN1A TP53
14 negative regulation of mitotic cell cycle GO:0045930 9.67 TP53 TNF BCL2
15 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.63 TP53 MDM2 CDKN1A
16 replicative senescence GO:0090399 9.43 TP53 ERCC1 CDKN1A
17 regulation of cell cycle GO:0051726 9.32 TP53 STAT3 MSH2 MDM2 CDKN1A BCL2

Molecular functions related to Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.23 TP53 TNF MALT1 BCL2

Sources for Cheilitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....