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MCID: CHL056
MIFTS: 47

Cheilitis

Categories: Oral diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cheilitis

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MalaCards integrated aliases for Cheilitis:

Name: Cheilitis 12 29 15

Classifications:

MalaCards categories:
Anatomical: Oral diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1762
ICD10 33 K13.0
MeSH 44 D002613
NCIt 50 C79545
UMLS 73 C0007971
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Summaries for Cheilitis

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Disease Ontology : 12 A lip disease characterized by the inflammation of the lips; which may include the perioral skin, the vermilion border and the labial mucosa.

MalaCards based summary : Cheilitis is related to actinic cheilitis and lip cancer. An important gene associated with Cheilitis is CAST (Calpastatin), and among its related pathways/superpathways are TNFR1 Pathway and Endometrial cancer. The drugs Imiquimod and Aminolevulinic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and salivary gland, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and cellular

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Related Diseases for Cheilitis

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Diseases related to Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 actinic cheilitis 33.9 MDM2 MSH2 TP53
2 lip cancer 29.4 MDM2 MSH2 SUMO1 TP53
3 lymphoma, non-hodgkin, familial 29.3 MALT1 MDM2 TP53
4 angular cheilitis 12.4
5 cheilitis glandularis 12.4
6 peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads 12.3
7 melkersson-rosenthal syndrome 11.8
8 actinic prurigo 11.2
9 orofacial granulomatosis 11.2
10 ectodermal dysplasia/skin fragility syndrome 10.9
11 immunodeficiency 12 10.9
12 ichthyosis follicularis atrichia photophobia syndrome 10.9
13 ring chromosome 7 10.6 MDM2 TP53
14 zika virus infection 10.6 MDM2 TP53
15 sclerosing liposarcoma 10.6 MDM2 TP53
16 periosteal osteogenic sarcoma 10.6 MDM2 TP53
17 dedifferentiated liposarcoma 10.5 MDM2 TP53
18 gliomatosis cerebri 10.5 MDM2 TP53
19 small cell sarcoma 10.5 MDM2 TP53
20 myxosarcoma 10.5 MDM2 TP53
21 embryonal sarcoma 10.4 MDM2 TP53
22 brain glioblastoma multiforme 10.4 MMP9 TP53
23 bone squamous cell carcinoma 10.4 SERPINB5 TP53
24 cerebral primitive neuroectodermal tumor 10.4 MSH2 TP53
25 anal fistula 10.4 MMP9 MSH2
26 crohn's disease 10.3
27 pigmented villonodular synovitis 10.3 MMP9 TP53
28 squamous cell carcinoma 10.3
29 diffuse large b-cell lymphoma 10.3 MALT1 MDM2 TP53
30 mantle cell lymphoma 10.3 MALT1 MDM2 TP53
31 dermatitis 10.1
32 grade iii astrocytoma 10.0 MDM2 MMP9 TP53
33 pleomorphic adenoma 10.0 MDM2 SERPINB5 TP53
34 stomatitis 10.0
35 thyroid lymphoma 10.0 TNF TP53
36 lichen sclerosus 10.0 TNF TP53
37 skin melanoma 10.0 MDM2 MMP9 TP53
38 female reproductive organ cancer 10.0 MMP9 MSH2 TP53
39 contact dermatitis 10.0
40 gingivitis 10.0
41 vulvitis 10.0
42 rhabdomyosarcoma 10.0 MDM2 MSH2 TP53
43 glossitis 9.9
44 lichen planus 9.9
45 angioedema 9.9
46 allergic contact dermatitis 9.9
47 periodontitis 9.9
48 lupus erythematosus 9.9
49 leishmaniasis 9.9
50 autoimmune inner ear disease 9.8 MMP9 TNF

Graphical network of the top 20 diseases related to Cheilitis:



Diseases related to Cheilitis
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Symptoms & Phenotypes for Cheilitis

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GenomeRNAi Phenotypes related to Cheilitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 SUMO1 TP53 HDAC2 MDM2 MSH2

MGI Mouse Phenotypes related to Cheilitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.09 CAST HDAC2 MDM2 MMP9 MSH2 SERPINB5
2 hematopoietic system MP:0005397 10.02 CAST HDAC2 MALT1 MDM2 MMP9 MSH2
3 digestive/alimentary MP:0005381 9.95 HDAC2 MDM2 MMP9 MSH2 SUMO1 TNF
4 immune system MP:0005387 9.92 MSH2 TNF TP53 MALT1 MDM2 MMP9
5 integument MP:0010771 9.8 MSH2 TNF TP53 CAST HDAC2 MDM2
6 mortality/aging MP:0010768 9.65 SUMO1 TNF TP53 CAST HDAC2 MALT1
7 limbs/digits/tail MP:0005371 9.63 CAST HDAC2 MDM2 MMP9 TNF TP53
8 neoplasm MP:0002006 9.1 HDAC2 MDM2 MMP9 MSH2 TNF TP53
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Drugs & Therapeutics for Cheilitis

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Drugs for Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
2
Aminolevulinic acid Approved Phase 4,Phase 1 106-60-5 137
3 Adjuvants, Immunologic Phase 4
4 Interferon Inducers Phase 4
5 interferons Phase 4
6 Methyl 5-aminolevulinate Phase 4,Phase 1
7 Dermatologic Agents Phase 4,Phase 2,Phase 1
8 Photosensitizing Agents Phase 4,Phase 1
9
Infliximab Approved Phase 2 170277-31-3
10
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
11
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
12
Isotretinoin Approved Phase 2 4759-48-2 5538 5282379
13
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
14 Antibodies Phase 2
15 Antibodies, Monoclonal Phase 2
16 Antirheumatic Agents Phase 2
17 Gastrointestinal Agents Phase 2
18 Immunoglobulins Phase 2
19 Calcineurin Inhibitors Phase 2
20 Immunosuppressive Agents Phase 2
21 Keratolytic Agents Phase 2
22 Protective Agents Phase 2
23 Radiation-Protective Agents Phase 2
24 Sunscreening Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic Therapy Completed NCT00849992 Phase 4 Imiquimod 5%
2 Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the Lip Completed NCT00868088 Phase 4
3 Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis Active, not recruiting NCT02409732 Phase 4 aminolevulinic acid hydrochloride
4 Use of Infliximab for the Treatment of Pemphigus Vulgaris Completed NCT00283712 Phase 2 Infliximab
5 Topical Tacrolimus 0.1% Ointment For Treatment Of Cutaneous Crohn's Disease Completed NCT01233570 Phase 2 Tacrolimus
6 Oral Isotretinoin Versus Topical Tretinoin for Actinic Keratosis Completed NCT02278861 Phase 2 Oral isotretinoin;Tretinoin 0,05% cream;Sunscreen FPS 60
7 Evaluation of Ingenol Mebutate for Actinic Cheilitis Treatment Not yet recruiting NCT03452566 Phase 1, Phase 2 Ingenol mebutate gel
8 Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Actinic Cheilitis Completed NCT02198469 Phase 1 Er:YAG AFL-PDT;MAL-PDT
9 Dental Hygienist Support Promotes Good Oral Health in Nursing Homes Completed NCT02676453 Not Applicable
10 Actinic Cheilitis Pre-Treated With DNA Repair Enzyme Cream Withdrawn NCT03224715 Not Applicable

Search NIH Clinical Center for Cheilitis

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Genetic Tests for Cheilitis

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Genetic tests related to Cheilitis:

# Genetic test Affiliating Genes
1 Cheilitis 29
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Anatomical Context for Cheilitis

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MalaCards organs/tissues related to Cheilitis:

41
Skin, Testes, Salivary Gland, T Cells, Tongue
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Publications for Cheilitis

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Articles related to Cheilitis:

(show top 50) (show all 578)
# Title Authors Year
1
Prevalence of and Factors Associated with Actinic Cheilitis in Extractive Mining Workers. ( 29898071 )
2018
2
A favorable response to omalizumab in a patient with cheilitis granulomatosa. ( 29426753 )
2018
3
Treating isotretinoin-associated cheilitis with hydrocortisone-containing lip balm. ( 29551370 )
2018
4
Surgical versus non-surgical treatment of actinic cheilitis: a systematic review and meta-analysis. ( 29908101 )
2018
5
Non-invasive imaging of actinic cheilitis and squamous cell carcinoma of the lip. ( 29725529 )
2018
6
A systematic review of the literature of the three related disease entities cheilitis granulomatosa, orofacial granulomatosis and Melkersson - Rosenthal syndrome. ( 29766816 )
2018
7
Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer. ( 29779037 )
2018
8
Expression of stem cell markers Nanog and Nestin in lip squamous cell carcinoma and actinic cheilitis. ( 29761881 )
2018
9
Erratum: Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis: erratum. ( 29552401 )
2018
10
Allergic contact cheilitis in an adolescent to Ricinus communis seed oil (castor oil) in a lip balm. ( 29749619 )
2018
11
Exfoliative Cheilitis as a Manifestation of Factitial Cheilitis. ( 29974020 )
2018
12
Evaluation of Cellular Proliferative Activity in Patients with Actinic Cheilitis through Silver-stained Nucleolar Organizer Region Method. ( 29728540 )
2018
13
Cheilitis Glandularis of Both Lips: Successful Treatment with a Combination of an Intralesional Steroid Injection and Tacrolimus Ointment. ( 29744227 )
2018
14
Immunoexpression of glucocorticoid receptor alpha (GRI+) isoform and apoptotic proteins (Bcl-2 and Bax) in actinic cheilitis and lower lip squamous cell carcinoma. ( 29935090 )
2018
15
Hyaluronic acid dermal fillers in the management of recurrent angular cheilitis: A case report. ( 29733533 )
2018
16
Dermoscopy and reflectance confocal microscopy for monitoring the treatment of actinic cheilitis with ingenol mebutate gel: Report of three cases. ( 29687567 )
2018
17
Metronidazole as a monotherapy in the management of granulomatous cheilitis. ( 29667611 )
2018
18
Malignant transformation of actinic cheilitis: A systematic review of observational studies. ( 29863311 )
2018
19
Herpes simplex reactivation after photodynamic therapy for actinic cheilitis in a patient with Non-Hodgkin Lymphoma: a possible indication for prophylaxis. ( 29512976 )
2018
20
Severely Crusted Cheilitis as an Initial Presentation of Systemic Lupus Erythematosus. ( 28794568 )
2017
21
Coexistence of Cheilitis Glandularis and Lichen Planus: Remarkable Response to Anti-inflammatory Treatments. ( 28979035 )
2017
22
Allergic contact cheilitis in children and improvement with patch testing. ( 28050593 )
2017
23
CD8+ and FoxP3+ T-cell infiltration in actinic cheilitis. ( 27778327 )
2017
24
Erfolgreiche Behandlung einer Cheilitis granulomatosa mit Infliximab bei Kindern. ( 29228481 )
2017
25
5-aminolaevulinic acid patch-photodynamic therapy in the treatment of actinic cheilitis. ( 28703320 )
2017
26
Immunoexpression of HDAC1, HDAC2, and HAT1 in actinic cheilitis and lip squamous cell carcinoma. ( 28107582 )
2017
27
A surprising granulomatous cheilitis. ( 28712755 )
2017
28
Cheilitis ( 29262127 )
2017
29
Treatment of exfoliative cheilitis with Traditional Chinese Medicine: a systematic review. ( 29960285 )
2017
30
Allergic contact cheilitis caused by olaflur in toothpaste. ( 27957754 )
2017
31
Granulomatous cheilitis mimicking angioedema. ( 28632806 )
2017
32
Allergic Contact Cheilitis From a Variety of Lip Balm Ingredients. ( 29039219 )
2017
33
Actinic cheilitis: proposition and reproducibility of a clinical criterion. ( 29607086 )
2017
34
Cheilitis Granulomatosa (Miescher Melkersson Rosenthal Syndrome) ( 29261927 )
2017
35
Diclofenac sodium gel therapy as an alternative to actinic cheilitis. ( 28986686 )
2017
36
Angular cheilitis: A clinical and microbial study. ( 29256466 )
2017
37
Chronic cheilitis: Faecal calprotectin test a way to diagnose oral Crohn's disease. ( 28731524 )
2017
38
Plasma Cell Cheilitis: A Clinicopathological and Immunohistochemical Study of 13 Cases. ( 28966508 )
2017
39
Miescher's cheilitis: Surgical management and long term outcome of an extremely severe case. ( 28192771 )
2017
40
Allergic contact cheilitis from anethole-containing toothpastes: a practical solution. ( 28214382 )
2017
41
i>?Development i>?i>?ofi>? i>?i>?a facescan 3D facial reconstruction technology methodA for quantitative evaluationA of cheilitis granulomatosa. ( 28465526 )
2017
42
Successful treatment of childhood cheilitis granulomatosa with infliximab. ( 28985456 )
2017
43
Recurrent angular cheilitis after secukinumab injections. ( 28620989 )
2017
44
Successful treatment of cheilitis granulomatosa by intralesional injections of pingyangmycin plus dexamethasone. ( 27628958 )
2016
45
New-onset oral lichen planus and granulomatous cheilitis in a 66-year-old woman. ( 27222882 )
2016
46
Cheilitis caused by to mint-containing toothpastes. ( 27620130 )
2016
47
Allergic contact cheilitis and hand dermatitis caused by a toothpaste. ( 26899811 )
2016
48
Automated algorithm for actinic cheilitis diagnosis by wide-field fluorescence imaging. ( 27981067 )
2016
49
Clinical features, cytology and bacterial culture results in dogs with and without cheilitis and comparison of three sampling techniques. ( 27019393 )
2016
50
A Case of Acrodermatitis Continua of Hallopeau Following Chronic Pustular Cheilitis. ( 26920763 )
2016
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Variations for Cheilitis

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Expression for Cheilitis

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Search GEO for disease gene expression data for Cheilitis.
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Pathways for Cheilitis

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Pathways related to Cheilitis according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
TNFR1 Pathway 64
Show member pathways
 12.71 MMP9 SUMO1 TNF TP53
2
Endometrial cancer 37
Show member pathways
 12.64 HDAC2 MDM2 MMP9 MSH2 TP53
3
Pathways in cancer 37
12.6 HDAC2 MDM2 MMP9 MSH2 TP53
4
Chks in Checkpoint Regulation 64
Show member pathways
 12.52 MDM2 MSH2 SUMO1 TP53
5
MicroRNAs in cancer 37
12.35 MDM2 MMP9 SERPINB5 TP53
6
Epstein-Barr virus infection 37
12.13 HDAC2 MDM2 TP53
7
Viral carcinogenesis 37
12.13 HDAC2 MDM2 TP53
8
p53 Signaling 64
Show member pathways
 12.1 HDAC2 MDM2 TP53
9
Apoptosis and Autophagy 4
12.09 MALT1 SERPINB5 TNF
10
C-type lectin receptor signaling pathway 37
Show member pathways
 12.05 MALT1 MDM2 TNF
11
Proteoglycans in cancer 37
12.04 MDM2 MMP9 TNF TP53
12
Integrated Breast Cancer Pathway 1
11.98 MDM2 MSH2 TP53
13
Transcriptional misregulation in cancer 37
11.94 HDAC2 MDM2 MMP9 TP53
14
Spinal Cord Injury 1
11.86 MMP9 TNF TP53
15
Thyroid hormone signaling pathway 37
11.84 HDAC2 MDM2 TP53
16
Interleukin-4 and 13 signaling 66
11.82 MMP9 TNF TP53
17
Colorectal Cancer Metastasis 64
11.78 MMP9 MSH2 TNF TP53
18
SMAD Signaling Network 64
11.71 HDAC2 MDM2 SUMO1 TP53
19
BRCA1 Pathway 64
Show member pathways
 11.66 HDAC2 MSH2 TP53
20
Glucocorticoid receptor regulatory network 1
11.65 HDAC2 MDM2 TP53
21
Fluid shear stress and atherosclerosis 37
11.6 MMP9 SUMO1 TNF TP53
22
Bladder cancer 37 1
11.59 MDM2 MMP9 TP53
23
Platinum drug resistance 37
11.58 MDM2 MSH2 TP53
24
NF-kB (NFkB) Pathway 67
11.56 MALT1 SUMO1 TNF
25
Signaling events mediated by HDAC Class I 1
11.51 HDAC2 SUMO1 TNF
26
Proteolysis Putative SUMO-1 pathway 22
Show member pathways
 11.37 MDM2 SUMO1 TP53
27
Integrated Cancer Pathway 1
11.24 MDM2 MSH2 TP53
28
Oncogene Induced Senescence 66
11.17 MDM2 TP53
29
Aurora A signaling 1
11.15 MDM2 TP53
30
Direct p53 effectors 1
11.14 HDAC2 MDM2 MSH2 SERPINB5 TP53
31
Canonical NF-kappaB pathway 1
10.99 MALT1 TNF
32
Inhibition of Ribosome Biogenesis by p14(ARF) 64
10.97 MDM2 TP53
33
Sumoylation by RanBP2 regulates transcriptional repression 1
10.63 MDM2 SUMO1
34
TP53 Network 1
Show member pathways
 10.47 MDM2 SUMO1 TP53
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GO Terms for Cheilitis

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Cellular components related to Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 8.92 HDAC2 MALT1 MDM2 TP53

Biological processes related to Cheilitis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.72 MMP9 SERPINB5 TNF
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.72 HDAC2 MDM2 SUMO1 TNF TP53
3 negative regulation of apoptotic process GO:0043066 9.65 HDAC2 MALT1 MDM2 MMP9 TP53
4 regulation of signal transduction by p53 class mediator GO:1901796 9.58 HDAC2 MDM2 TP53
5 negative regulation of DNA binding GO:0043392 9.57 HDAC2 SUMO1
6 response to antibiotic GO:0046677 9.56 MDM2 TP53
7 negative regulation of transcription, DNA-templated GO:0045892 9.55 HDAC2 MDM2 SUMO1 TNF TP53
8 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.54 MSH2 TP53
9 positive regulation of release of cytochrome c from mitochondria GO:0090200 9.52 MMP9 TP53
10 cellular response to gamma radiation GO:0071480 9.51 MDM2 TP53
11 positive regulation of protein complex assembly GO:0031334 9.49 SUMO1 TNF
12 response to X-ray GO:0010165 9.48 MSH2 TP53
13 positive regulation of protein export from nucleus GO:0046827 9.46 MDM2 TP53
14 morphogenesis of an epithelium GO:0002009 9.43 KRT6A SERPINB5
15 determination of adult lifespan GO:0008340 9.37 MSH2 TP53
16 cellular response to actinomycin D GO:0072717 8.96 MDM2 TP53
17 positive regulation of vascular smooth muscle cell proliferation GO:1904707 8.8 MDM2 MMP9 TNF

Molecular functions related to Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.65 MALT1 MDM2 MMP9 TNF TP53
2 disordered domain specific binding GO:0097718 9.37 MDM2 TP53
3 SUMO transferase activity GO:0019789 9.16 MDM2 SUMO1
4 protease binding GO:0002020 9.13 MALT1 TNF TP53
5 enzyme binding GO:0019899 9.02 HDAC2 MDM2 MSH2 SUMO1 TP53
6 protein binding GO:0005515 10.06 CAST HDAC2 KRT6A MALT1 MDM2 MMP9
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Sources for Cheilitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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