Cheilitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology: ¹¹ A lip disease characterized by the inflammation of the lips; which may include the perioral skin, the vermilion border and the labial mucosa.

MalaCards based summary: Cheilitis is related to actinic keratosis and lichen planus. An important gene associated with Cheilitis is CAST (Calpastatin), and among its related pathways/superpathways are Innate Immune System and Signal Transduction. The drugs Imiquimod and Aminolevulinic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, salivary gland and lymph node, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia: ⁷⁵ Cheilitis is a medical condition characterized by inflammation of the lips. The inflammation may include... more...

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Related Diseases for Cheilitis

Diseases related to Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 412)

#	Related Disease	Score	Top Affiliating Genes
1	actinic keratosis	30.9	TP53 TNF BCL2
2	lichen planus	30.7	TP53 TNF CD1A
3	keratosis	30.7	TP53 MMP9 FGFR3 BCL2
4	squamous cell carcinoma, head and neck	30.3	TP53 STAT3 MMP9 FGFR3 CSF2 CDKN1A
5	histiocytosis	30.2	TNF CSF2 CD1A
6	squamous cell carcinoma	30.2	TP53 STAT3 MMP9 MDM2 FGFR3 CDKN1A
7	leprosy 3	30.2	TNF CSF2 CD1A
8	exanthem	30.0	TNF PDCD1 CSF2 CD274
9	severe cutaneous adverse reaction	29.9	TNF PDCD1 CD274
10	suppressor of tumorigenicity 3	29.9	TP53 CDKN1A BCL2
11	anus disease	29.9	TP53 TNF CD274
12	fungal infectious disease	29.8	TNF STAT3 CSF2
13	skin benign neoplasm	29.8	TP53 STAT3 MSH2 FGFR3
14	skin carcinoma	29.8	TP53 TNF PDCD1 MSH2 CD274 BCL2
15	acquired immunodeficiency syndrome	29.7	TP53 TNF CSF2 BCL2
16	vitiligo-associated multiple autoimmune disease susceptibility 1	29.7	TNF PDCD1 CD274
17	lymphoid interstitial pneumonia	29.7	TNF STAT3 CSF2 CD1A
18	lymphangioma	29.5	TP53 TNF STAT3 MSH2 BCL2
19	lymphoma, hodgkin, classic	29.5	TP53 STAT3 MDM2 CSF2 BCL2
20	aplastic anemia	29.5	TP53 TNF MSH2 ERCC1 CSF2
21	neutropenia	29.4	TP53 TNF ERCC1 CSF2 BCL2
22	keratoacanthoma	29.4	TP53 STAT3 MSH2 CDKN1A CD1A BCL2
23	myocarditis	29.4	TNF STAT3 MMP9 CD274 BCL2
24	acute promyelocytic leukemia	29.3	TP53 TNF STAT3 CSF2 CDKN1A BCL2
25	autoimmune disease	29.2	TNF STAT3 PDCD1 MMP9 CD274
26	systemic lupus erythematosus	29.0	TP53 TNF STAT3 PDCD1 MMP9 CSF2
27	basal cell carcinoma	29.0	TP53 TNF STAT3 MSH2 MMP9 ERCC1
28	skin disease	28.8	TP53 TNF STAT3 PDCD1 MMP9 KRT6A
29	lymphoma	28.8	TP53 STAT3 PDCD1 MDM2 MALT1 CD274
30	lymphoma, non-hodgkin, familial	28.7	TP53 STAT3 MSH2 MDM2 MALT1 CSF2
31	angular cheilitis	11.6
32	cheilitis glandularis	11.6
33	actinic cheilitis	11.6
34	peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads	11.5
35	melkersson-rosenthal syndrome	11.5
36	actinic prurigo	11.2
37	mucoepithelial dysplasia, hereditary	10.9
38	ectodermal dysplasia/skin fragility syndrome	10.9
39	immunodeficiency 12	10.9
40	factor xi deficiency	10.7
41	crohn's disease	10.6
42	bell's palsy	10.4
43	fissured tongue	10.4
44	contact dermatitis	10.3
45	esophagus verrucous carcinoma	10.3	TP53 MDM2
46	polyploidy	10.3	TP53 CDKN1A
47	facial paralysis	10.3
48	dermatitis	10.3
49	stomatitis	10.3
50	senile entropion	10.3	TNF CSF2

Graphical network of the top 20 diseases related to Cheilitis:

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Symptoms & Phenotypes for Cheilitis

GenomeRNAi Phenotypes related to Cheilitis according to GeneCards Suite gene sharing:

²⁵ (show all 37)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-10	10.21	FGFR3
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-100	10.21	KRT6A
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-113	10.21	KRT6A
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-114	10.21	FGFR3 KRT6A
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-116	10.21	MSH2
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-121	10.21	FGFR3
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-137	10.21	KRT6A
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-14	10.21	MSH2
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-145	10.21	ERCC1
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-151	10.21	MSH2
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-159	10.21	KRT6A
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-161	10.21	ERCC1
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-169	10.21	ERCC1
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-176	10.21	MSH2
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-18	10.21	ERCC1
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-181	10.21	ERCC1
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-204	10.21	ERCC1
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	10.21	MSH2
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-30	10.21	PDCD1
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-33	10.21	KRT6A
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-36	10.21	PDCD1
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-47	10.21	PDCD1
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-52	10.21	FGFR3
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-53	10.21	MSH2
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-56	10.21	KRT6A
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-58	10.21	KRT6A
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-59	10.21	FGFR3 PDCD1
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-60	10.21	FGFR3
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	10.21	ERCC1 FGFR3 PDCD1
30	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	10.21	ERCC1 FGFR3
31	Increased shRNA abundance (Z-score > 2)	GR00366-A-90	10.21	KRT6A
32	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	10.18	CDKN1A PDCD1 TNF
33	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	10.18	CDKN1A ERCC1 PDCD1 TNF TP53
34	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-3	10.18	CDKN1A ERCC1 TP53 CEACAM3 MDM2 MSH2
35	no effect	GR00402-S-1	10.17	APEX1 BCL2 CAST CD1A CD274 CDKN1A
36	no effect	GR00402-S-2	10.17	APEX1 BCL2 CAST CD1A CD274 CDKN1A
37	Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)	GR00104-A-0	9.56	CSF2 MSH2 PDCD1 TNF

MGI Mouse Phenotypes related to Cheilitis:

⁴⁵ (show all 23)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.47	APEX1 BCL2 CAST CD274 CDKN1A CSF2
2	growth/size/body region	MP:0005378	10.46	APEX1 BCL2 CAST CDKN1A CSF2 CTNNBIP1
3	nervous system	MP:0003631	10.45	BCL2 CAST CDKN1A CSF2 CTNNBIP1 ERCC1
4	neoplasm	MP:0002006	10.42	APEX1 BCL2 CDKN1A CSF2 ERCC1 FGFR3
5	cellular	MP:0005384	10.4	APEX1 BCL2 CAST CD274 CDKN1A CSF2
6	renal/urinary system	MP:0005367	10.34	BCL2 CDKN1A CSF2 CTNNBIP1 ERCC1 FGFR3
7	immune system	MP:0005387	10.34	APEX1 BCL2 CAST CD274 CDKN1A CSF2
8	muscle	MP:0005369	10.29	APEX1 BCL2 CDKN1A ERCC1 MDM2 MMP9
9	behavior/neurological	MP:0005386	10.27	BCL2 CAST CD274 CDKN1A CSF2 ERCC1
10	digestive/alimentary	MP:0005381	10.26	BCL2 CDKN1A CTNNBIP1 FGFR3 KRT6A MDM2
11	cardiovascular system	MP:0005385	10.26	APEX1 BCL2 CAST CDKN1A CSF2 CTNNBIP1
12	endocrine/exocrine gland	MP:0005379	10.25	APEX1 BCL2 CDKN1A CSF2 ERCC1 MDM2
13	embryo	MP:0005380	10.24	APEX1 BCL2 CDKN1A CSF2 CTNNBIP1 ERCC1
14	craniofacial	MP:0005382	10.21	BCL2 CDKN1A CSF2 CTNNBIP1 FGFR3 KRT6A
15	liver/biliary system	MP:0005370	10.19	APEX1 CDKN1A ERCC1 MDM2 PDCD1 STAT3
16	adipose tissue	MP:0005375	10.12	BCL2 CDKN1A CSF2 ERCC1 STAT3 TNF
17	reproductive system	MP:0005389	10.11	APEX1 BCL2 CDKN1A CSF2 ERCC1 FGFR3
18	skeleton	MP:0005390	10.1	CD274 CDKN1A CSF2 CTNNBIP1 ERCC1 FGFR3
19	respiratory system	MP:0005388	10.06	CDKN1A CSF2 CTNNBIP1 FGFR3 MMP9 PDCD1
20	hematopoietic system	MP:0005397	10.06	BCL2 CAST CD274 CDKN1A CSF2 CTNNBIP1
21	vision/eye	MP:0005391	9.96	BCL2 CDKN1A CTNNBIP1 ERCC1 FGFR3 MMP9
22	mortality/aging	MP:0010768	9.91	APEX1 BCL2 CAST CD274 CDKN1A CSF2
23	integument	MP:0010771	9.47	BCL2 CD274 CDKN1A CSF2 ERCC1 FGFR3

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Drugs & Therapeutics for Cheilitis

Drugs for Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Imiquimod

Approved, Investigational

Phase 4

99011-02-6

57469

2

Aminolevulinic acid

Approved

Phase 4

106-60-5

137

3

Adjuvants, Immunologic

Phase 4

4

interferons

Phase 4

5

Dermatologic Agents

Phase 4

6

Immunologic Factors

Phase 4

7

Methyl 5-aminolevulinate

Phase 4

8

Photosensitizing Agents

Phase 4

9

Chitosan low molecular weight (20-200 mpa.s)

Experimental

Phase 1

14257-69-3, 9012-76-4

441477 71853

10

Radiation-Protective Agents

Phase 1

11

Sunscreening Agents

Phase 1

12

Protective Agents

Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Clinical Trial of ALA Photodynamic Therapy for Treatment of Actinic Cheilitis in Patients With Squamous Cell Carcinoma of the Lip.	Completed	NCT00868088	Phase 4
2	Randomized Prospective Study Comparing 5% Imiquimod and Photodynamic Therapy for Actinic Cheilitis	Completed	NCT00849992	Phase 4	Imiquimod 5%
3	Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis	Completed	NCT02409732	Phase 4	aminolevulinic acid hydrochloride
4	Trichloroacetic Acid as a Topical Treatment for Actinic Cheilitis	Recruiting	NCT04744103	Phase 4	TCA
5	Photodynamic Therapy With Metil 5-aminolevulinate for Actinic Cheilitis - A Phase 2 Randomized Double-blind Placebo Controlled Clinical Trial	Unknown status	NCT03990636	Phase 2	Metil 5-aminolevulinate
6	Phase 1/2 Clinical Trial for the Evaluation of Ingenol Mebutate for Actinic Cheilitis	Withdrawn	NCT03452566	Phase 1, Phase 2	Ingenol mebutate gel
7	A Randomized, Prospective Study Comparing Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Ablative Fractional Laser Treatment for Actinic Cheilitis	Completed	NCT02198469	Phase 1	Er:YAG AFL-PDT;MAL-PDT
8	Evaluation of Topical Application of 5% Imiquimod, 0.05% Imiquimod and 0.05% Nanoencapsulated Imiquimod Gel in the Treatment of Actinic Cheilitis: a Randomized Controlled Trial	Terminated	NCT04219358	Phase 1	Vehicle Gel Base;Imiquimod 5% gel;Imiquimod 0,05% gel;Imiquimod nanoencapsulated 0,05% gel;Lip sunscreen 30 Sun Protector Factor (SPF);Dexpanthenol
9	Actinic Cheilitis Pre-Treated With DNA Repair Enzyme Cream	Withdrawn	NCT03224715

Search NIH Clinical Center for Cheilitis

Cochrane evidence based reviews: cheilitis

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Genetic Tests for Cheilitis

Genetic tests related to Cheilitis:

#	Genetic test	Affiliating Genes
1	Cheilitis ²⁸

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Anatomical Context for Cheilitis

Organs/tissues related to Cheilitis:

MalaCards : Skin, Salivary Gland, Lymph Node, Nk Cells, Prostate, Bone Marrow, Liver

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Publications for Cheilitis

Articles related to Cheilitis:

(show top 50) (show all 1761)

#	Title	Authors	PMID	Year
1	Upgrading removable denture design by using strategic implants: A case report. ⁶²	Al Jaghsi A...Mundt T	36183934	2023
2	Immunohistochemical comparative analysis of IMP-3 and KI-67 in actinic cheilitis and lower lip squamous cell carcinoma. ⁶²	de Souza Martins Camara AC...de Souza LB	34817714	2022
3	Cheilitis caused by allergic contact dermatitis to cinnamon in chai tea: a case report. ⁶²	Patel K...Tate B	36461791	2022
4	Correction: First isolation and identification of Cystobasidium calyptogenae from the oral samples of an elderly patient presenting with angular cheilitis. ⁶²	Karajacob AS...Tay ST	36471451	2022
5	Zinc Deficiency with Cheilitis: A Report of Five Cases. ⁶²	Ota M...Mabuchi T	36420553	2022
6	Contact cheilitis due to continuous respiratory protection for COVID-19. ⁶²	Vieira Esteves C...Lemos CA	34914158	2022
7	[Translated article] Glandular Cheilitis: Rare or Underdiagnosed? ⁶²	Garcia Castro R...Godoy Gijon E	36206812	2022
8	[Occupational Dermatoses in Healthcare Workers during the COVID-19 Pandemic: A Narrative Review]. ⁶²	Vasques AI...Rocha L	35766244	2022
9	Combination of CO2 laser therapy and pulsed dye laser therapy for the treatment of actinic cheilitis. ⁶²	Cortonesi G...Trovato E	36382418	2022
10	Dermoscopic findings in a case of plasma cell cheilitis. ⁶²	Truffello D...Morgan P	36088186	2022
11	Glandular Cheilitis: Rare or Underdiagnosed? ⁶²	Garcia Castro R...Godoy Gijon E	35525279	2022
12	Sézary syndrome: Report of a rare case with perioral manifestation and review of the literature. ⁶²	Rodrigues-Fernandes CI...Santos-Silva AR	36183500	2022
13	Oral manifestations associated with inflammatory bowel disease and early endoscopic findings in patients with spondyloarthritis. ⁶²	Alvarado-Julio A...Romero-Sanchez C	36348398	2022
14	Clinical predictors of malignant transformation and recurrence in oral potentially malignant disorders: A systematic review and meta-analysis. ⁶²	Paglioni MP...Santos-Silva AR	36153299	2022
15	Evidence-Based Clinical Practice Guidelines for Laser-Assisted Drug Delivery. ⁶²	Labadie JG...Alam M	35976634	2022
16	Laminin Immunostaining in Biopsies as a Useful Biomarker of Early Invasion in Actinic Cheilitis and Differential Diagnosis Between Actinic Cheilitis and Lip Cancer: New Insights. ⁶²	Vageli D...Ioannou M	36303015	2022
17	Allergic contact cheilitis in Melbourne, Australia. ⁶²	Mizutani H...Nixon R	35611494	2022
18	Lip mesotherapy with dexpanthenol in the treatment of isotretinoin-induced cheilitis. ⁶²	Metin N...Turan C	35426210	2022
19	Sun protection as a protective factor for actinic cheilitis: Cross-sectional population-based study. ⁶²	Lucena IM...Rados PV	33751725	2022
20	Randomized Clinical Trial of Conventional versus Indoor Daylight Photodynamic Therapy for Treatment of Actinic Cheilitis. ⁶²	Arisi M...Calzavara-Pinton P	35907163	2022
21	Atomoxetine-Associated Angular Cheilitis. ⁶²	Kirlioglu SS...Unaldi N	32235145	2022
22	Clinical predictors of metal allergic sensitization in orthodontic patients. ⁶²	Zigante M...Spalj S	36239365	2022
23	Oral Manifestations of Systemic Lupus Erythematosus: A Systematic Review. ⁶²	Garcia-Rios P...Onate-Sanchez RE	36231212	2022
24	S2k guideline: Laser therapy of the skin. ⁶²	Paasch U...Nast A	36098675	2022
25	Delayed onset Crohn's disease following cheilitis granulomatosa: A case report. ⁶²	Iwata H...Ohtsuki M	35514072	2022
26	Oral manifestations of autoimmune polyglandular syndrome type 1. ⁶²	Tenorio JR...Gallottini M	35182449	2022
27	The Role of Reflectance Confocal Microscopy in the Evaluation of Pigmented Oral Lesions and Their Relationship With Histopathological Aspects. ⁶²	Luppi JB...Lourenco SV	35503878	2022
28	[Pemphigus vulgaris clinically masquerading as cheilitis: report of two cases]. ⁶²	Zhang QY...Zeng X	36097946	2022
29	New Approach to Addison Disease: Oral Manifestations Due to Endocrine Dysfunction and Comorbidity Burden. ⁶²	Bugala NM...Alexandru DO	36140482	2022
30	Borderline tuberculoid leprosy misdiagnosed as Cheilitis Granulomatosa Miescher: A case report. ⁶²	Sitaula S...Mishra A	35957798	2022
31	Skin manifestations of neuroendocrine neoplasms: review of the literature. ⁶²	Walecka I...Walecki J	36090712	2022
32	Cheilitis: A cross-sectional study-multiple factors involved in the aetiology and clinical features. ⁶²	Blagec T...Lugovic-Mihic L	36001068	2022
33	Effects of Blue Light on the Skin and Its Therapeutic Uses: Photodynamic Therapy and Beyond. ⁶²	Pieper C...Wysong A	35917260	2022
34	Concerning the assessment of outcomes in the treatment of actinic cheilitis. Comment on: "Cheilitis Actinica: topical treatment with 3.75% imiquimod". ⁶²	Garbers LEFM...Miot HA	35512062	2022
35	Actinic cheilitis or squamous cell carcinoma of the lip? Practical recommendations on how to avoid a trap. ⁶²	Rezende HD...Dinato SLM	35946758	2022
36	In vivo reflectance confocal microscopy diagnostic features of actinic cheilitis: a retrospective case series. ⁶²	Zhang MY...Jiang WW	35181949	2022
37	Actinic cheilitis: Proposal of a clinical index. ⁶²	Medeiros CK...Oliveira PT	35660729	2022
38	Cheilitis Actinica: topical treatment with 3.75% imiquimod. ⁶²	Kopera D	35220604	2022
39	Current treatment modalities in granulomatous cheilitis. ⁶²	Pathania YS	35174873	2022
40	A case of squamous cell carcinoma arising from plasma cell cheilitis. ⁶²	Nishimori N...Fujita H	34363694	2022
41	Efficacy of photodynamic therapy in actinic cheilitis: A systematic review. ⁶²	Yang Y...Wang X	35218940	2022
42	Knowledge, Practice, and Awareness of Oral Cancer and HPV Infection among Dental Students and Residents: A Cross-Sectional Study. ⁶²	Murariu A...Hurjui L	35744069	2022
43	Dermoscopy in the diagnosis and assessment of treatment response in granulomatous cheilitis. ⁶²	Adya KA...Inamadar A	35750429	2022
44	[Relationship between peripheral blood micronutrients and four kinds of oral mucosal diseases in children: clinical analysis of 217 cases]. ⁶²	Zhou Y...Lin XP	36204956	2022
45	Toxicity, Genotoxicity, and Carcinogenicity of Isotretinoin: A review. ⁶²	Yilmaz S	35619315	2022
46	Crohn's Disease Presenting as Metabolic Myopathy: A Case Report. ⁶²	George SK...Joseph TK	35864676	2022
47	Long COVID Oral Cavity Symptoms Based on Selected Clinical Cases. ⁶²	Rafalowicz B...Rafalowicz J	34921381	2022
48	Reply to: current treatment modalities in granulomatous cheilitis. ⁶²	Amanullah AA...Secrest AM	35553064	2022
49	[The effect of four immunosuppressive drugs on oral manifestations after organ transplantation]. ⁶²	Zhao WJ...Yao H	36110078	2022
50	Epithelial-mesenchymal transition modulates lower lip carcinogenesis and promotes cancer progression. ⁶²	de Farias Morais HG...de Almeida Freitas R	35240445	2022

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Genes for Cheilitis

Genes related to Cheilitis (0 elite genes):

(show all 21)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CAST	Calpastatin	Protein Coding	21.33	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
2	TP53	Tumor Protein P53	Protein Coding	12.87	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	TNF	Tumor Necrosis Factor	Protein Coding	12.54	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
4	KRT6A	Keratin 6A	Protein Coding	11.76	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
5	CD1A	CD1a Molecule	Protein Coding	11.48	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
6	MALT1	MALT1 Paracaspase	Protein Coding	11.41	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
7	MDM2	MDM2 Proto-Oncogene	Protein Coding	11.31	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
8	CSF2	Colony Stimulating Factor 2	Protein Coding	11.28	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
9	MSH2	MutS Homolog 2	Protein Coding	11.25	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
10	MMP9	Matrix Metallopeptidase 9	Protein Coding	11.15	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
11	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	11.04	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
12	CD274	CD274 Molecule	Protein Coding	10.91	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
13	BCL2	BCL2 Apoptosis Regulator	Protein Coding	10.62	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
14	PDCD1	Programmed Cell Death 1	Protein Coding	10.5	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
15	ERCC1	ERCC Excision Repair 1, Endonuclease Non-Catalytic Subunit	Protein Coding	10.32	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
16	APEX1	Apurinic/Apyrimidinic Endodeoxyribonuclease 1	Protein Coding	10.22	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
17	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	7.59	GeneCards inferred via : Publications (show sections)
18	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	7.59	GeneCards inferred via : Publications (show sections)
19	CEACAM3	CEA Cell Adhesion Molecule 3	Protein Coding	7.24	GeneCards inferred via : Publications (show sections)
20	CTNNBIP1	Catenin Beta Interacting Protein 1	Protein Coding	7.24	GeneCards inferred via : Publications (show sections)
21	HAT1	Histone Acetyltransferase 1	Protein Coding	7.24	GeneCards inferred via : Publications (show sections)

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Variations for Cheilitis

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Expression for Cheilitis

Search GEO for disease gene expression data for Cheilitis.

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Pathways for Cheilitis

Pathways related to Cheilitis according to GeneCards Suite gene sharing:

(show top 50) (show all 62)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.92	TP53 TNF STAT3 PDCD1 MMP9 MALT1
2	Signal Transduction ⁶⁶	13.73	BCL2 CD274 CDKN1A CSF2 CTNNBIP1 FGFR3
3	MIF Mediated Glucocorticoid Regulation ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ Overview of proinflammatory and profibrotic mediators ⁷⁴ PEDF Induced Signaling ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.63	TP53 TNF STAT3 MMP9 FGFR3 CSF2
4	Prolactin Signaling ⁶⁴ Show member pathways Development Prolactin receptor signaling ²² EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ⁷⁴ ErbB Family Pathway ⁶⁴ ErbB signaling pathway ⁷⁴ ErbB2-ErbB3 Heterodimers ⁶⁴ ErbB4 Pathway ⁶⁴ Estrogen-stimulated signaling through PRKCZ ⁶⁶ Glioblastoma Multiforme ⁶⁴ Glioblastoma signaling pathways ⁷⁴ Growth Hormone Signaling ⁶⁴ HMGB1 Pathway ⁶⁴ IL-2 Pathway ⁶⁴ LPS Stimulated MAPK Signaling ⁶⁴ PACAP Signaling ⁶⁴ PI3K Signaling in B-Lymphocyte ⁶⁴ TCA cycle nutrient use and invasiveness of ovarian cancer ⁷⁴ Thrombopoietin Pathway ⁶⁴ TREM1 Pathway ⁶⁴ UVA-Induced MAPK Signaling ⁶⁴ UVB-Induced MAPK Signaling ⁶⁴ UVC-Induced MAPK Signaling ⁶⁴	13.47	TP53 TNF STAT3 MDM2 MALT1 FGFR3
5	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.39	TP53 TNF STAT3 MDM2 FGFR3 CSF2
6	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.32	TP53 TNF STAT3 MMP9 CSF2 CDKN1A
7	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.83	TP53 TNF STAT3 MMP9 CDKN1A BCL2
8	Endometrial cancer ⁷⁴ Show member pathways Chromosomal and microsatellite instability in colorectal cancer ⁷⁴ Melanoma ⁷⁴ Non-small cell lung cancer ⁷⁴ Pancreatic adenocarcinoma pathway ⁷⁴ Signal transduction PTEN pathway ²²	12.62	TP53 STAT3 MSH2 MDM2 FGFR3 CDKN1A
9	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.57	TP53 TNF STAT3 MSH2 CDKN1A BCL2
10	NF-kappaB Signaling ³	12.54	TNF STAT3 PDCD1 MALT1 CD274 APEX1
11	Chks in Checkpoint Regulation ⁶⁴ Show member pathways DNA Repair Mechanisms ⁶⁴ Estrogen-mediated S-Phase Entry ⁶⁴ G2-M Phase Transition ⁶⁴ SREBP Proteolysis ⁶⁴	12.51	TP53 MSH2 MDM2 ERCC1 CDKN1A BCL2
12	DNA Damage ³	12.47	APEX1 CDKN1A ERCC1 MDM2 MSH2 TP53
13	Malignant pleural mesothelioma ⁷⁴	12.47	TP53 MMP9 MDM2 FGFR3 CSF2 CDKN1A
14	Breast cancer pathway ⁷⁴ Show member pathways Embryonic stem cell pluripotency pathways ⁷⁴	12.45	TP53 STAT3 MDM2 FGFR3 CDKN1A
15	NF-kappaB Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ Apoptosis Pathway ⁷⁰	12.44	TP53 MDM2 FGFR3 BCL2
16	Death Receptor Signaling ⁶⁷ Show member pathways Apoptosis and survival Apoptotic TNF-family pathways ²² Apoptosis Signaling Pathway ⁶⁵ SARS-CoV-1-mediated effects on programmed cell death ⁶⁶ TNF Signaling ⁶⁷	12.37	TP53 TNF CDKN1A BCL2
17	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ⁶⁷ IL-17 signaling pathway ⁷⁴ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.28	TNF STAT3 MMP9 CSF2
18	MAPK Signaling: Mitogens ⁶⁵ Show member pathways Akt Signaling Pathway ⁶⁵	12.22	TP53 MDM2 FGFR3 CDKN1A BCL2
19	p53 Signaling ⁶⁴ Show member pathways p53 Pathway ⁶⁷	12.2	TP53 MDM2 CDKN1A BCL2
20	Integrated breast cancer pathway ⁷⁴	12.14	BCL2 MDM2 MSH2 TP53
21	Colorectal Cancer Metastasis ⁶⁴	12.1	CDKN1A MMP9 MSH2 STAT3 TNF TP53
22	Direct p53 effectors ⁶¹	12	TP53 MSH2 MDM2 CDKN1A BCL2
23	Spinal cord injury ⁷⁴	11.98	APEX1 MMP9 TNF TP53
24	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	11.98	TP53 TNF PDCD1 MALT1 CSF2 CDKN1A
25	Senescence and autophagy in cancer ⁷⁴	11.93	TP53 MDM2 CDKN1A BCL2
26	DNA damage response (only ATM dependent) ⁷⁴	11.91	TP53 MDM2 CDKN1A BCL2
27	Small cell lung cancer ⁷⁴	11.89	TP53 CDKN1A BCL2
28	p53 transcriptional gene network ⁷⁴	11.88	TNF MSH2 CDKN1A
29	Retinoblastoma gene in cancer ⁷⁴	11.83	TP53 MDM2 CDKN1A
30	ATM Pathway ⁶⁴ Show member pathways ATM signaling pathway ⁷⁴	11.81	TP53 MDM2 CDKN1A
31	DNA IR-damage and cellular response via ATR ⁷⁴	11.8	TP53 MSH2 MDM2
32	Acute viral myocarditis ⁷⁴	11.77	STAT3 MMP9 BCL2
33	Glucocorticoid receptor regulatory network ⁶¹	11.77	TP53 MDM2 CSF2 CDKN1A
34	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.76	CD1A CSF2 TNF
35	Head and neck squamous cell carcinoma ⁷⁴	11.75	TP53 FGFR3 CDKN1A
36	AP-1 transcription factor network ⁶¹	11.72	TP53 MMP9 CSF2
37	Transcription_P53 signaling pathway ²²	11.7	TP53 MDM2 CDKN1A BCL2 APEX1
38	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.68	TNF MMP9 CSF2
39	Lung fibrosis ⁷⁴	11.68	TNF MMP9 CSF2
40	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.67	TP53 TNF STAT3 MMP9 CDKN1A BCL2
41	Regulation of retinoblastoma protein ⁶¹	11.61	CDKN1A CSF2 MDM2
42	Hepatitis C and hepatocellular carcinoma ⁷⁴	11.6	TP53 STAT3 CDKN1A
43	HIF1Alpha Pathway ⁶⁴	11.59	TP53 MDM2 APEX1
44	FGF signaling pathway ⁶¹	11.59	STAT3 MMP9 FGFR3
45	Interactions between immune cells and microRNAs in tumor microenvironment ⁷⁴	11.53	STAT3 PDCD1 CD274
46	Interleukin-10 signaling ⁶⁶	11.51	TNF STAT3 CSF2
47	DNA damage_ATM/ATR regulation of G1/S checkpoint ²²	11.48	TP53 MDM2 CDKN1A
48	Busulfan Pathway, Pharmacodynamics ⁶⁰ Show member pathways Catalytic cycle of mammalian flavin-containing monooxygenases (FMOs) ⁷⁴ Defective FMO3 causes TMAU ⁶⁶ FMO oxidises nucleophiles ⁶⁶	11.46	STAT3 MSH2 BCL2 APEX1
49	Oxidative damage response ⁷⁴	11.43	TNF CDKN1A BCL2
50	Kynurenine pathway and links to cell senescence ⁷⁴ Show member pathways Tryptophan catabolism ⁶⁶	11.38	TP53 TNF CDKN1A

Sources

GO Terms for Cheilitis

Biological processes related to Cheilitis according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of apoptotic process	GO:0043066	10.27	TP53 TNF MMP9 MDM2 MALT1 BCL2
2	apoptotic process	GO:0006915	10.25	TP53 TNF PDCD1 MMP9 MDM2 FGFR3
3	cellular response to DNA damage stimulus	GO:0006974	10.11	APEX1 BCL2 CDKN1A ERCC1 MSH2 TP53
4	positive regulation of miRNA transcription	GO:1902895	10.03	TP53 TNF STAT3
5	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	9.97	TNF CSF2 BCL2
6	cell population proliferation	GO:0008283	9.92	BCL2 CSF2 ERCC1 STAT3 TP53
7	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO:0042771	9.91	TP53 MSH2 CDKN1A
8	cellular response to gamma radiation	GO:0071480	9.88	TP53 MDM2 CDKN1A
9	B cell lineage commitment	GO:0002326	9.84	TP53 BCL2
10	cellular response to actinomycin D	GO:0072717	9.78	TP53 MDM2
11	response to X-ray	GO:0010165	9.73	TP53 MSH2 ERCC1
12	T cell lineage commitment	GO:0002360	9.72	TP53 BCL2
13	signal transduction by p53 class mediator	GO:0072331	9.7	CDKN1A TP53
14	negative regulation of mitotic cell cycle	GO:0045930	9.67	TP53 TNF BCL2
15	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO:0006977	9.63	TP53 MDM2 CDKN1A
16	replicative senescence	GO:0090399	9.43	TP53 ERCC1 CDKN1A
17	regulation of cell cycle	GO:0051726	9.32	TP53 STAT3 MSH2 MDM2 CDKN1A BCL2

Molecular functions related to Cheilitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protease binding	GO:0002020	9.23	TP53 TNF MALT1 BCL2

Sources

Sources for Cheilitis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: CHL056 MIFTS: 47	Cheilitis Categories: Gastrointestinal diseases, Oral diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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