Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: CHL056
MIFTS: 46

Cheilitis

Categories: Oral diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Cheilitis

About this section

MalaCards integrated aliases for Cheilitis:

Name: Cheilitis 12 29 44 15

Classifications:

MalaCards categories:
Anatomical: Oral diseases Skin diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1762
MeSH 44 D002613
NCIt 50 C79545
SNOMED-CT 68 7847004
ICD10 33 K13.0
UMLS 72 C0007971
Sources

Summaries for Cheilitis

About this section
Disease Ontology : 12 A lip disease characterized by the inflammation of the lips; which may include the perioral skin, the vermilion border and the labial mucosa.

MalaCards based summary : Cheilitis is related to actinic cheilitis and glossitis. An important gene associated with Cheilitis is CAST (Calpastatin), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Isotretinoin and Salicylic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and salivary gland, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and cellular

Wikipedia : 75 Cheilitis is inflammation of the lips. This inflammation may include the perioral skin (the skin around... more...

Sources

Related Diseases for Cheilitis

About this section

Diseases related to Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 222)
# Related Disease Score Top Affiliating Genes
1 actinic cheilitis 33.5 TP53 MSH2 MDM2 HDAC2
2 glossitis 30.5 TNF KRT6A
3 lip cancer 30.1 TP53 SUMO1 MSH2 MDM2
4 anal fistula 29.8 MSH2 MMP9
5 intestinal disease 29.6 TP53 TNF MSH2
6 pyoderma 28.7 TNF MMP9
7 gastrointestinal system disease 28.5 TP53 TNF MSH2 MMP9
8 angular cheilitis 12.7
9 cheilitis glandularis 12.7
10 peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads 12.7
11 melkersson-rosenthal syndrome 12.2
12 orofacial granulomatosis 11.6
13 actinic prurigo 11.5
14 glucagonoma 11.5
15 ectodermal dysplasia/skin fragility syndrome 11.2
16 immunodeficiency 12 11.2
17 ichthyosis follicularis atrichia photophobia syndrome 11.2
18 plummer vinson syndrome 11.2
19 crohn's disease 10.7
20 keratosis 10.5
21 zika virus infection 10.5 TP53 MDM2
22 ring chromosome 7 10.5 TP53 MDM2
23 sclerosing liposarcoma 10.5 TP53 MDM2
24 actinic keratosis 10.5
25 sapho syndrome 10.5 TP53 MDM2
26 facial paralysis 10.5
27 squamous cell carcinoma 10.5
28 periosteal osteogenic sarcoma 10.5 TP53 MDM2
29 dedifferentiated liposarcoma 10.4 TP53 MDM2
30 contact dermatitis 10.4
31 gliomatosis cerebri 10.4 TP53 MDM2
32 stomatitis 10.4
33 small cell sarcoma 10.4 TP53 MDM2
34 lichen planus 10.4
35 myxosarcoma 10.4 TP53 MDM2
36 sarcoidosis 1 10.4
37 dermatitis 10.4
38 embryonal sarcoma 10.4 TP53 MDM2
39 verrucous carcinoma 10.3 TP53 MDM2
40 gingivitis 10.3
41 fissured tongue 10.3
42 vulvitis 10.3
43 cardia cancer 10.3 TP53 MDM2
44 neurofibromatosis, type ii 10.3
45 allergic contact dermatitis 10.3
46 cerebral primitive neuroectodermal tumor 10.3 TP53 MSH2
47 kala-azar 1 10.2
48 candidiasis 10.2
49 angioedema 10.2
50 leishmaniasis 10.2

Graphical network of the top 20 diseases related to Cheilitis:



Diseases related to Cheilitis
Sources

Symptoms & Phenotypes for Cheilitis

About this section

GenomeRNAi Phenotypes related to Cheilitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 HDAC2 MDM2 MSH2 SUMO1 TP53

MGI Mouse Phenotypes related to Cheilitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.03 CAST HDAC2 MDM2 MMP9 MSH2 SUMO1
2 hematopoietic system MP:0005397 9.97 CAST HDAC2 MALT1 MDM2 MMP9 MSH2
3 digestive/alimentary MP:0005381 9.95 HDAC2 MDM2 MMP9 MSH2 SUMO1 TNF
4 immune system MP:0005387 9.92 CAST HDAC2 MALT1 MDM2 MMP9 MSH2
5 integument MP:0010771 9.8 CAST HDAC2 MDM2 MMP9 MSH2 TNF
6 limbs/digits/tail MP:0005371 9.63 CAST HDAC2 MDM2 MMP9 TNF TP53
7 mortality/aging MP:0010768 9.61 CAST HDAC2 MALT1 MDM2 MMP9 MSH2
8 neoplasm MP:0002006 9.1 HDAC2 MDM2 MMP9 MSH2 TNF TP53
Sources

Drugs & Therapeutics for Cheilitis

About this section

Drugs for Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isotretinoin Approved Phase 4 4759-48-2 5282379 5538
2
Salicylic acid Approved, Investigational, Vet_approved Phase 4 69-72-7 338
3
Ciclopirox Approved, Investigational Phase 4 29342-05-0 2749
4
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
5
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
6
Aminolevulinic acid Approved Phase 4 106-60-5 137
7 Peripheral Nervous System Agents Phase 4
8 Analgesics Phase 4
9 Anti-Inflammatory Agents Phase 4
10 Salicylates Phase 4
11 Cyclooxygenase Inhibitors Phase 4
12 Antifungal Agents Phase 4
13 Anti-Infective Agents Phase 4
14 Analgesics, Non-Narcotic Phase 4
15 Anti-Inflammatory Agents, Non-Steroidal Phase 4
16 Keratolytic Agents Phase 4
17 Antirheumatic Agents Phase 4
18 Adjuvants, Immunologic Phase 4
19 Methyl 5-aminolevulinate Phase 4
20 Immunologic Factors Phase 4
21 interferons Phase 4
22 Interferon Inducers Phase 4
23 Dermatologic Agents Phase 4
24 Photosensitizing Agents Phase 4
25
Chitosan Experimental Phase 2 9012-76-4 71853
26 Radiation-Protective Agents Phase 2
27 Protective Agents Phase 2
28 Sunscreening Agents Phase 2
29 Terephthalylidene dicamphor sulfonic acid Phase 2
30 Coagulants Phase 2
31 Lipid Regulating Agents Phase 2
32 Hemostatics Phase 2
33 Hypolipidemic Agents Phase 2
34 Chelating Agents Phase 2
35 Anticholesteremic Agents Phase 2
36 Antimetabolites Phase 2
37
Lidocaine Approved, Vet_approved Phase 1 137-58-6 3676
38
Prilocaine Approved Phase 1 721-50-6 4906
39 Anesthetics, Local Phase 1
40 Sodium Channel Blockers Phase 1
41 Lidocaine, Prilocaine Drug Combination Phase 1
42 Diuretics, Potassium Sparing Phase 1
43 Central Nervous System Depressants Phase 1
44 Anesthetics Phase 1
45 Anti-Arrhythmia Agents Phase 1

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Clinical, Laboratorial and Quality of Life Trial to Evaluate the Efficacy and Safety of Low-dose Oral Isotretinoin for Seborrhea. Unknown status NCT01139749 Phase 4 oral isotretinoin;salicylic acid and ciclopirox olamine
2 Randomized Prospective Study Comparing 5% Imiquimod and Photodynamic Therapy for Actinic Cheilitis Completed NCT00849992 Phase 4 Imiquimod 5%
3 Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis Completed NCT02409732 Phase 4 aminolevulinic acid hydrochloride
4 A Clinical Trial of ALA Photodynamic Therapy for Treatment of Actinic Cheilitis in Patients With Squamous Cell Carcinoma of the Lip. Completed NCT00868088 Phase 4
5 Phase II Randomized Controlled Trial to Evaluate the Clinical and Histological Effects of Oral Isotretinoin for the Treatment of Photoaging on Face and Forearms Completed NCT00701740 Phase 2 oral isotretinoin and Mexoryl SX / XL;Mexoryl XL / SX
6 A Randomized Controlled Trial of the Efficacy and Safety of a a Biofunctional Textile in the Management of Atopic Dermatitis Completed NCT01597817 Phase 2
7 Photodynamic Therapy With Metil 5-aminolevulinate for Actinic Cheilitis - A Phase 2 Randomized Double-blind Placebo Controlled Clinical Trial Not yet recruiting NCT03990636 Phase 2 Metil 5-aminolevulinate
8 Phase 1/2 Clinical Trial for the Evaluation of Ingenol Mebutate for Actinic Cheilitis Withdrawn NCT03452566 Phase 1, Phase 2 Ingenol mebutate gel
9 A Randomized, Prospective Study Comparing Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Ablative Fractional Laser Treatment for Actinic Cheilitis Completed NCT02198469 Phase 1 Er:YAG AFL-PDT;MAL-PDT
10 Efficacy of Iontophoresis-assisted Ablative Fractional Laser Photodynamic Therapy With Short Incubation Time for the Treatment of Actinic Keratosis: 12-month Follow-up Results of a Prospective, Randomised, Comparative Trial Completed NCT02670655 Phase 1 lidocaine/prilocaine (5%) application;MAL application
11 A Randomised Trial Comparing Methyl Aminolaevulinate Photodynamic Therapy With and Without Ablative Fractional Laser Treatment in Patients With Microinvasive Squamous Cell Carcinoma: Results From a 24-month Follow-up Completed NCT02666534 Phase 1 lidocaine-prilocaine 5% cream application;methyl-aminolevulinate application
12 Acute Abdomen in Kawasaki Disease: Case Reports Completed NCT03902262
13 Actinic Cheilitis Pre-Treated With DNA Repair Enzyme Cream Withdrawn NCT03224715

Search NIH Clinical Center for Cheilitis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Bendazac
Phenol

Cochrane evidence based reviews: cheilitis

Sources

Genetic Tests for Cheilitis

About this section

Genetic tests related to Cheilitis:

# Genetic test Affiliating Genes
1 Cheilitis 29
Sources

Anatomical Context for Cheilitis

About this section

MalaCards organs/tissues related to Cheilitis:

41
Skin, Testes, Salivary Gland, Liver, T Cells, Prostate, Breast
Sources

Publications for Cheilitis

About this section

Articles related to Cheilitis:

(show top 50) (show all 1511)
# Title Authors PMID Year
1
Proper management of suspicious actinic cheilitis. 38
31032237 2019
2
Oral and Otorhinolaryngological Findings in Adults Who Were Diagnosed With Pediatric Onset Crohn's Disease: A Controlled Study. 38
29912762 2019
3
Treatments of actinic cheilitis: a systematic review of the literature. 38
31400450 2019
4
A novel homozygous nonsense mutation in CAST associated with PLACK syndrome. 38
31392520 2019
5
Combined zinc and vitamin B6 deficiency in a patient with diffuse red rash and angular cheilitis 6 years after Roux-en-Y gastric bypass. 38
31377720 2019
6
Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis. 38
31066083 2019
7
Prevalence of Oral Lesions and Correlation with Intestinal Symptoms of Inflammatory Bowel Disease: A Systematic Review. 38
31311171 2019
8
Cutaneous candidiasis - an evidence-based review of topical and systemic treatments to inform clinical practice. 38
31287594 2019
9
Detection of human papillomaviruses and human polyomaviruses in immunosuppressed and immunocompetent individuals with actinic cheilitis: a case series. 38
31281986 2019
10
Lymphoplasmacytic Granulomatosis Cheilitis Treated with Cheiloplasty. 38
31360289 2019
11
Hold the spice: Allergy to garlic and sulfites-Possible relevance in a patient with cheilitis granulomatosa. 38
31237355 2019
12
Actinic Cheilitis: Analysis of Clinical Subtypes, Risk Factors and Associated Signs of Actinic Damage. 38
31197386 2019
13
DNA Repair Enzyme Containing Lip Balm for the Treatment of Actinic Cheilitis: A Pilot Study 38
31251551 2019
14
Ointment Pseudo-Cheilitis: A Disease Distinct From Factitial Cheilitis. A Series of 13 Patients From São Paulo, Brazil. 38
30654637 2019
15
Surgical versus non-surgical treatment of actinic cheilitis: A systematic review and meta-analysis. 38
29908101 2019
16
Propylthiouracil-induced anti-neutrophil cytoplasmic antibody-associated vasculitis mimicking Kawasaki disease. 38
29457989 2019
17
Analysis of risk factors for maxillary denture-related oral mucosal lesions: A cross-sectional study. 38
31011141 2019
18
Digital scanning for implant-supported fixed complete-arch dental prostheses for patients with epidermolysis bullosa: A case series evaluation. 38
31079885 2019
19
Successful treatment of cheilitis granulomatosa with lenalidomide. 38
31063601 2019
20
Treatment of actinic cheilitis: a systematic review. 38
31011833 2019
21
Cheilitis granulomatosa and Crohn's disease : a case report. 38
31314197 2019
22
An oral manifestation of IBD: Pyostomatitis vegetant, about two cases. 38
31035024 2019
23
Plasma cell cheilitis: the diagnosis of a disorder mimicking lip cancer. 38
30963053 2019
24
Ingenol mebutate versus imiquimod versus diclofenac for actinic cheilitis: a 6-month follow-up clinical study. 38
30242791 2019
25
A 30-year follow-up study of patients with Melkersson-Rosenthal syndrome shows an association to inflammatory bowel disease. 38
30983435 2019
26
Candidiasis: Red and White Manifestations in the Oral Cavity. 38
30693459 2019
27
Risk factors associated with oral manifestations and oral health impact of gastro-oesophageal reflux disease: a multicentre, cross-sectional study in Pakistan. 38
30928919 2019
28
Cheilitis and gingivitis as first signs of Crohn's disease in a pediatric patient. 38
30847214 2019
29
Immune response and evasion mechanisms in lip carcinogenesis: An immunohistochemical study. 38
30468994 2019
30
Actinic cheilitis and lip squamous cell carcinoma: Literature review and new data from Brazil. 38
30697396 2019
31
Allergic reactions in oral and perioral diseases-what do allergy skin test results show? 38
30228058 2019
32
"Fresh Breath" on Toothpaste: Peppermint as Cause of Cheilitis. 38
30570581 2019
33
Daylight photodynamic therapy for the treatment of actinic cheilitis. 38
30066408 2019
34
Fludroxycortide cream as an alternative therapy for actinic cheilitis. 38
30673866 2019
35
The prevalence of developmental anomalies among school children in Southern district of Andhra Pradesh, India. 38
31110441 2019
36
[Oral health in patients with systemic sclerosis]. 38
31322605 2019
37
Evidence regarding how surgical treatment of actinic cheilitis compares with nonsurgical treatment is not trustworthy and does not consider all important outcomes. 38
30119827 2019
38
Dermatologic Lesions Submitted to an Oral and Maxillofacial Pathology Biopsy Service: An Analysis of 2487 Cases. 38
29340950 2018
39
Oral health in Alzheimer's disease: a multicenter case-control study. 38
29476334 2018
40
Evaluation the efficacy of trichloroacetic acid (TCA) 33% in treatment of oral retinoid-induced cheilitis compared with placebo (Vaseline): a randomized pilot study. 38
29464980 2018
41
Oral isotretinoin for acne. 38
30484286 2018
42
Dermatologic findings of vitamin B12 deficiency in infants. 38
30307060 2018
43
Allergic contact cheilitis caused by lauryl PCA. 38
30019410 2018
44
Malignant transformation of actinic cheilitis: A systematic review of observational studies. 38
29863311 2018
45
Actinic Cheilitis Prevalence and Risk Factors: A Cross-sectional, Multicentre Study in a Population Aged 45 Years and Over in North-west Spain. 38
30085328 2018
46
Rapidly growing verrucous axillary tumors, multiple erosions, pustules, and cheilitis. 38
30211479 2018
47
Rasch wachsende verruköse axilläre Tumoren, multiple Erosionen, Pusteln und Cheilitis. 38
30300479 2018
48
Expression of stem cell markers Nanog and Nestin in lip squamous cell carcinoma and actinic cheilitis. 38
29761881 2018
49
Daylight Photodynamic Therapy for Actinic Keratoses. 38
29752702 2018
50
Oral mucositis associated with anti-EGFR therapy in colorectal cancer: single institutional retrospective cohort study. 38
30290786 2018
Sources

Variations for Cheilitis

About this section
Sources

Expression for Cheilitis

About this section
Search GEO for disease gene expression data for Cheilitis.
Sources

Pathways for Cheilitis

About this section

Pathways related to Cheilitis according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Endometrial cancer 37
Show member pathways
 12.65 TP53 MSH2 MMP9 MDM2 HDAC2
2
Pathways in cancer 37
12.6 TP53 MSH2 MMP9 MDM2 HDAC2
3
Chks in Checkpoint Regulation 64
Show member pathways
 12.52 TP53 SUMO1 MSH2 MDM2
4
Viral carcinogenesis 37
12.13 TP53 MDM2 HDAC2
5
p53 Signaling 64
Show member pathways
 12.08 TP53 MDM2 HDAC2
6
Proteoglycans in cancer 37
12.07 TP53 TNF MMP9 MDM2
7
C-type lectin receptor signaling pathway 37
Show member pathways
 12.05 TNF MDM2 MALT1
8
Integrated Breast Cancer Pathway 1
11.98 TP53 MSH2 MDM2
9
Transcriptional misregulation in cancer 37
11.97 TP53 MMP9 MDM2 HDAC2
10
Spinal Cord Injury 1
11.86 TP53 TNF MMP9
11
Thyroid hormone signaling pathway 37
11.85 TP53 MDM2 HDAC2
12
Interleukin-4 and 13 signaling 66
11.82 TP53 TNF MMP9
13
Colorectal Cancer Metastasis 64
11.78 TP53 TNF MSH2 MMP9
14
SMAD Signaling Network 64
11.71 TP53 SUMO1 MDM2 HDAC2
15
BRCA1 Pathway 64
Show member pathways
 11.67 TP53 MSH2 HDAC2
16
Glucocorticoid receptor regulatory network 1
11.66 TP53 MDM2 HDAC2
17
Platinum drug resistance 37
11.6 TP53 MSH2 MDM2
18
Fluid shear stress and atherosclerosis 37
11.6 TP53 TNF SUMO1 MMP9
19
Bladder cancer 37 1
11.59 TP53 MMP9 MDM2
20
NF-kB (NFkB) Pathway 67
11.57 TNF SUMO1 MALT1
21
Signaling events mediated by HDAC Class I 1
11.52 TNF SUMO1 HDAC2
22
DNA damage_Role of Brca1 and Brca2 in DNA repair 22
11.42 TP53 MSH2 MALT1
23
Proteolysis Putative SUMO-1 pathway 22
Show member pathways
 11.4 TP53 SUMO1 MDM2
24
Transcription_P53 signaling pathway 22
11.4 TP53 SUMO1 MDM2 HDAC2
25
Direct p53 effectors 1
11.38 TP53 MSH2 MDM2 HDAC2
26
Integrated Cancer Pathway 1
11.27 TP53 MSH2 MDM2
27
Oncogene Induced Senescence 66
11.16 TP53 MDM2
28
Aurora A signaling 1
11.14 TP53 MDM2
29
Canonical NF-kappaB pathway 1
10.99 TNF MALT1
30
Inhibition of Ribosome Biogenesis by p14(ARF) 64
10.97 TP53 MDM2
31
Sumoylation by RanBP2 regulates transcriptional repression 1
10.63 SUMO1 MDM2
32
TP53 Network 1
Show member pathways
 10.14 TP53 SUMO1 MDM2
Sources

GO Terms for Cheilitis

About this section

Biological processes related to Cheilitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.72 TP53 TNF SUMO1 MDM2 HDAC2
2 negative regulation of apoptotic process GO:0043066 9.65 TP53 MMP9 MDM2 MALT1 HDAC2
3 negative regulation of transcription, DNA-templated GO:0045892 9.55 TP53 TNF SUMO1 MDM2 HDAC2
4 lipopolysaccharide-mediated signaling pathway GO:0031663 9.54 TNF MALT1
5 negative regulation of DNA binding GO:0043392 9.52 SUMO1 HDAC2
6 response to antibiotic GO:0046677 9.51 TP53 MDM2
7 positive regulation of release of cytochrome c from mitochondria GO:0090200 9.49 TP53 MMP9
8 cellular response to gamma radiation GO:0071480 9.48 TP53 MDM2
9 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.46 TP53 MSH2
10 positive regulation of protein complex assembly GO:0031334 9.43 TNF SUMO1
11 positive regulation of protein export from nucleus GO:0046827 9.4 TP53 MDM2
12 determination of adult lifespan GO:0008340 9.37 TP53 MSH2
13 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.13 TNF MMP9 MDM2
14 cellular response to actinomycin D GO:0072717 8.62 TP53 MDM2

Molecular functions related to Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.9 TP53 TNF SUMO1 MSH2 MMP9 MDM2
2 identical protein binding GO:0042802 9.72 TP53 TNF MMP9 MDM2 MALT1
3 enzyme binding GO:0019899 9.35 TP53 SUMO1 MSH2 MDM2 HDAC2
4 SUMO transferase activity GO:0019789 8.96 MDM2
5 protease binding GO:0002020 8.92 TP53 TNF MALT1 CAST
Sources

Sources for Cheilitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....