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MCID: CHL056
MIFTS: 47

Cheilitis

Categories: Oral diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cheilitis

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MalaCards integrated aliases for Cheilitis:

Name: Cheilitis 12 29 44 15

Classifications:

MalaCards categories:
Anatomical: Oral diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1762
ICD10 33 K13.0
MeSH 44 D002613
NCIt 50 C79545
SNOMED-CT 68 7847004
UMLS 73 C0007971
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Summaries for Cheilitis

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Disease Ontology : 12 A lip disease characterized by the inflammation of the lips; which may include the perioral skin, the vermilion border and the labial mucosa.

MalaCards based summary : Cheilitis is related to actinic cheilitis and glossitis. An important gene associated with Cheilitis is CAST (Calpastatin), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Aminolevulinic acid and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and brain, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and cellular

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Related Diseases for Cheilitis

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Diseases related to Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 actinic cheilitis 33.9 MDM2 MSH2 TP53
2 glossitis 30.3 KRT6A TNF
3 lip cancer 30.0 MDM2 MSH2 SUMO1 TP53
4 angular cheilitis 12.6
5 cheilitis glandularis 12.6
6 peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads 12.4
7 melkersson-rosenthal syndrome 12.0
8 orofacial granulomatosis 11.5
9 actinic prurigo 11.4
10 ectodermal dysplasia/skin fragility syndrome 11.0
11 immunodeficiency 12 11.0
12 ichthyosis follicularis atrichia photophobia syndrome 11.0
13 plummer vinson syndrome 11.0
14 crohn's disease 10.5
15 squamous cell carcinoma 10.4
16 dermatitis 10.3
17 ring chromosome 7 10.2 MDM2 TP53
18 zika virus infection 10.2 MDM2 TP53
19 sclerosing liposarcoma 10.2 MDM2 TP53
20 periosteal osteogenic sarcoma 10.2 MDM2 TP53
21 gliomatosis cerebri 10.2 MDM2 TP53
22 dedifferentiated liposarcoma 10.2 MDM2 TP53
23 small cell sarcoma 10.2 MDM2 TP53
24 vulvitis 10.2
25 stomatitis 10.2
26 myxosarcoma 10.2 MDM2 TP53
27 brain glioblastoma multiforme 10.2 MMP9 TP53
28 verrucous carcinoma 10.2 MDM2 TP53
29 anal fistula 10.1 MMP9 MSH2
30 embryonal sarcoma 10.1 MDM2 TP53
31 contact dermatitis 10.1
32 pigmented villonodular synovitis 10.1 MMP9 TP53
33 thyroid lymphoma 10.1 TNF TP53
34 cardia cancer 10.1 MDM2 TP53
35 attenuated familial adenomatous polyposis 10.1 APEX1 MSH2
36 cerebral primitive neuroectodermal tumor 10.1 MSH2 TP53
37 gingivitis 10.1
38 leishmaniasis 10.1
39 lichen planus 10.1
40 autoimmune inner ear disease 10.1 MMP9 TNF
41 chronic salpingitis 10.1 TNF TP53
42 scleritis 10.1 MMP9 TNF
43 grade iii astrocytoma 10.1 MDM2 MMP9 TP53
44 skin melanoma 10.1 MDM2 MMP9 TP53
45 periodontosis 10.0 MMP9 TNF
46 soft tissue sarcoma 10.0 MDM2 TNF TP53
47 diverticulitis 10.0 MMP9 TNF
48 angioedema 10.0
49 iron metabolism disease 10.0
50 allergic contact dermatitis 10.0

Graphical network of the top 20 diseases related to Cheilitis:



Diseases related to Cheilitis
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Symptoms & Phenotypes for Cheilitis

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GenomeRNAi Phenotypes related to Cheilitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.1 APEX1 HDAC2 MDM2 MSH2 SUMO1 TP53

MGI Mouse Phenotypes related to Cheilitis:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.19 APEX1 CAST HDAC2 MDM2 MMP9 MSH2
2 growth/size/body region MP:0005378 10.06 APEX1 HDAC2 MDM2 MMP9 SERPINB5 SUMO1
3 cardiovascular system MP:0005385 10.05 APEX1 CAST HDAC2 MDM2 MMP9 TNF
4 hematopoietic system MP:0005397 10.03 CAST HDAC2 MDM2 MMP9 MSH2 SERPINB5
5 digestive/alimentary MP:0005381 10.02 HDAC2 MDM2 MMP9 MSH2 SUMO1 TNF
6 immune system MP:0005387 10.01 APEX1 CAST HDAC2 MDM2 MMP9 MSH2
7 mortality/aging MP:0010768 9.96 APEX1 CAST HDAC2 MDM2 MMP9 MSH2
8 integument MP:0010771 9.91 CAST HDAC2 MDM2 MMP9 MSH2 TNF
9 limbs/digits/tail MP:0005371 9.8 CAST HDAC2 MDM2 MMP9 TNF TP53
10 muscle MP:0005369 9.63 APEX1 HDAC2 MDM2 MMP9 TNF TP53
11 neoplasm MP:0002006 9.5 APEX1 HDAC2 MDM2 MMP9 MSH2 TNF
12 normal MP:0002873 9.1 APEX1 HDAC2 MDM2 SERPINB5 SUMO1 TP53
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Drugs & Therapeutics for Cheilitis

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Drugs for Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 4,Phase 1 106-60-5 137
2
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
3 Photosensitizing Agents Phase 4,Phase 1
4 Dermatologic Agents Phase 4,Phase 2,Phase 1
5 Immunologic Factors Phase 4,Phase 2
6 Methyl 5-aminolevulinate Phase 4,Phase 1
7 Interferon Inducers Phase 4
8 Adjuvants, Immunologic Phase 4
9 interferons Phase 4
10
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
11
Infliximab Approved Phase 2 170277-31-3
12
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
13
Isotretinoin Approved Phase 2 4759-48-2 5538 5282379
14
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
15 Immunoglobulins Phase 2
16 Gastrointestinal Agents Phase 2
17 Antibodies Phase 2
18 Antibodies, Monoclonal Phase 2
19 Antirheumatic Agents Phase 2
20 Calcineurin Inhibitors Phase 2
21 Immunosuppressive Agents Phase 2
22 Keratolytic Agents Phase 2
23 Sunscreening Agents Phase 2
24 Radiation-Protective Agents Phase 2
25 Protective Agents Phase 2

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis Completed NCT02409732 Phase 4 aminolevulinic acid hydrochloride
2 Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic Therapy Completed NCT00849992 Phase 4 Imiquimod 5%
3 Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the Lip Completed NCT00868088 Phase 4
4 Use of Infliximab for the Treatment of Pemphigus Vulgaris Completed NCT00283712 Phase 2 Infliximab
5 Topical Tacrolimus 0.1% Ointment For Treatment Of Cutaneous Crohn's Disease Completed NCT01233570 Phase 2 Tacrolimus
6 Oral Isotretinoin Versus Topical Tretinoin for Actinic Keratosis Completed NCT02278861 Phase 2 Oral isotretinoin;Tretinoin 0,05% cream;Sunscreen FPS 60
7 Evaluation of Ingenol Mebutate for Actinic Cheilitis Treatment Not yet recruiting NCT03452566 Phase 1, Phase 2 Ingenol mebutate gel
8 Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Actinic Cheilitis Completed NCT02198469 Phase 1 Er:YAG AFL-PDT;MAL-PDT
9 Dental Hygienist Support Promotes Good Oral Health in Nursing Homes Completed NCT02676453 Not Applicable
10 Periodontal Outcomes After Sanative Therapy Enrolling by invitation NCT03649789
11 Actinic Cheilitis Pre-Treated With DNA Repair Enzyme Cream Withdrawn NCT03224715 Not Applicable

Search NIH Clinical Center for Cheilitis

Cochrane evidence based reviews: cheilitis

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Genetic Tests for Cheilitis

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Genetic tests related to Cheilitis:

# Genetic test Affiliating Genes
1 Cheilitis 29
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Anatomical Context for Cheilitis

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MalaCards organs/tissues related to Cheilitis:

41
Skin, Testes, Brain, Bone, Breast, Tonsil, Thyroid
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Publications for Cheilitis

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Articles related to Cheilitis:

(show top 50) (show all 605)
# Title Authors Year
1
Prevalence of and Factors Associated with Actinic Cheilitis in Extractive Mining Workers. ( 29898071 )
2018
2
A favorable response to omalizumab in a patient with cheilitis granulomatosa. ( 29426753 )
2018
3
Treating isotretinoin-associated cheilitis with hydrocortisone-containing lip balm. ( 29551370 )
2018
4
Surgical versus non-surgical treatment of actinic cheilitis: a systematic review and meta-analysis. ( 29908101 )
2018
5
Non-invasive imaging of actinic cheilitis and squamous cell carcinoma of the lip. ( 29725529 )
2018
6
A systematic review of the literature of the three related disease entities cheilitis granulomatosa, orofacial granulomatosis and Melkersson - Rosenthal syndrome. ( 29766816 )
2018
7
Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer. ( 29779037 )
2018
8
Expression of stem cell markers Nanog and Nestin in lip squamous cell carcinoma and actinic cheilitis. ( 29761881 )
2018
9
Erratum: Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis: erratum. ( 29552401 )
2018
10
Allergic contact cheilitis in an adolescent to Ricinus communis seed oil (castor oil) in a lip balm. ( 29749619 )
2018
11
Exfoliative Cheilitis as a Manifestation of Factitial Cheilitis. ( 29974020 )
2018
12
Evaluation of Cellular Proliferative Activity in Patients with Actinic Cheilitis through Silver-stained Nucleolar Organizer Region Method. ( 29728540 )
2018
13
Cheilitis Glandularis of Both Lips: Successful Treatment with a Combination of an Intralesional Steroid Injection and Tacrolimus Ointment. ( 29744227 )
2018
14
Immunoexpression of glucocorticoid receptor alpha (GRI+) isoform and apoptotic proteins (Bcl-2 and Bax) in actinic cheilitis and lower lip squamous cell carcinoma. ( 29935090 )
2018
15
Hyaluronic acid dermal fillers in the management of recurrent angular cheilitis: A case report. ( 29733533 )
2018
16
Dermoscopy and reflectance confocal microscopy for monitoring the treatment of actinic cheilitis with ingenol mebutate gel: Report of three cases. ( 29687567 )
2018
17
Metronidazole as a monotherapy in the management of granulomatous cheilitis. ( 29667611 )
2018
18
Malignant transformation of actinic cheilitis: A systematic review of observational studies. ( 29863311 )
2018
19
Herpes simplex reactivation after photodynamic therapy for actinic cheilitis in a patient with Non-Hodgkin Lymphoma: a possible indication for prophylaxis. ( 29512976 )
2018
20
Daylight photodynamic therapy for the treatment of actinic cheilitis. ( 30066408 )
2018
21
Actinic Cheilitis Prevalence and Risk Factors: A Cross-sectional, Multicentre Study in a Population Aged 45 Years and Over in North-west Spain. ( 30085328 )
2018
22
Evidence regarding how surgical treatment of actinic cheilitis compares with nonsurgical treatment is not trustworthy and does not consider all important outcomes. ( 30119827 )
2018
23
Ingenol mebutate versus imiquimod versus diclofenac for actinic cheilitis: a 6-month follow-up clinical study. ( 30242791 )
2018
24
Hyaluronic acid dermal fillers in the management of recurrent angular cheilitis: a case report. ( 30095087 )
2018
25
Angular cheilitis induced by iron deficiency anemia. ( 30102595 )
2018
26
Evaluation the efficacy of trichloroacetic acid (TCA) 33% in treatment of oral retinoid-induced cheilitis compared with placebo (Vaseline): a randomized pilot study. ( 29464980 )
2018
27
Cheilitis: An unusual presentation of Mucocutaneous Leishmaniasis. ( 29988622 )
2018
28
Allergic contact cheilitis caused by lauryl PCA. ( 30019410 )
2018
29
Rapidly growing verrucous axillary tumors, multiple erosions, pustules, and cheilitis. ( 30211479 )
2018
30
Rasch wachsende verruköse axilläre Tumoren, multiple Erosionen, Pusteln und Cheilitis. ( 30300479 )
2018
31
Devriesea agamarum associated cheilitis in a North African spiny-tailed lizard (Uromastyx acanthinura) in Spain. ( 30425957 )
2018
32
Differential Diagnosis of Cheilitis - How to Classify Cheilitis? ( 30431729 )
2018
33
Severely Crusted Cheilitis as an Initial Presentation of Systemic Lupus Erythematosus. ( 28794568 )
2017
34
Coexistence of Cheilitis Glandularis and Lichen Planus: Remarkable Response to Anti-inflammatory Treatments. ( 28979035 )
2017
35
Allergic contact cheilitis in children and improvement with patch testing. ( 28050593 )
2017
36
CD8+ and FoxP3+ T-cell infiltration in actinic cheilitis. ( 27778327 )
2017
37
Erfolgreiche Behandlung einer Cheilitis granulomatosa mit Infliximab bei Kindern. ( 29228481 )
2017
38
5-aminolaevulinic acid patch-photodynamic therapy in the treatment of actinic cheilitis. ( 28703320 )
2017
39
Immunoexpression of HDAC1, HDAC2, and HAT1 in actinic cheilitis and lip squamous cell carcinoma. ( 28107582 )
2017
40
A surprising granulomatous cheilitis. ( 28712755 )
2017
41
Cheilitis ( 29262127 )
2017
42
Treatment of exfoliative cheilitis with Traditional Chinese Medicine: a systematic review. ( 29960285 )
2017
43
Allergic contact cheilitis caused by olaflur in toothpaste. ( 27957754 )
2017
44
Granulomatous cheilitis mimicking angioedema. ( 28632806 )
2017
45
Allergic Contact Cheilitis From a Variety of Lip Balm Ingredients. ( 29039219 )
2017
46
Actinic cheilitis: proposition and reproducibility of a clinical criterion. ( 29607086 )
2017
47
Cheilitis Granulomatosa (Miescher Melkersson Rosenthal Syndrome) ( 29261927 )
2017
48
Diclofenac sodium gel therapy as an alternative to actinic cheilitis. ( 28986686 )
2017
49
Angular cheilitis: A clinical and microbial study. ( 29256466 )
2017
50
Chronic cheilitis: Faecal calprotectin test a way to diagnose oral Crohn's disease. ( 28731524 )
2017
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Variations for Cheilitis

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Expression for Cheilitis

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Search GEO for disease gene expression data for Cheilitis.
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Pathways for Cheilitis

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Pathways related to Cheilitis according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Endometrial cancer 37
Show member pathways
 12.7 HDAC2 MDM2 MMP9 MSH2 TP53
2
Pathways in cancer 37
12.64 HDAC2 MDM2 MMP9 MSH2 TP53
3
Chks in Checkpoint Regulation 64
Show member pathways
 12.44 APEX1 MDM2 MSH2 SUMO1 TP53
4
MicroRNAs in cancer 37
12.39 MDM2 MMP9 SERPINB5 TP53
5
DNA Damage 4
12.37 APEX1 MDM2 MSH2 TP53
6
Viral carcinogenesis 37
12.13 HDAC2 MDM2 TP53
7
Epstein-Barr virus infection 37
12.11 HDAC2 MDM2 TNF TP53
8
Proteoglycans in cancer 37
12.1 MDM2 MMP9 TNF TP53
9
p53 Signaling 64
Show member pathways
 12.09 HDAC2 MDM2 TP53
10
Transcriptional misregulation in cancer 37
12.03 HDAC2 MDM2 MMP9 TP53
11
Integrated Breast Cancer Pathway 1
12 MDM2 MSH2 TP53
12
Colorectal Cancer Metastasis 64
11.92 MMP9 MSH2 TNF TP53
13
Thyroid hormone signaling pathway 37
11.87 HDAC2 MDM2 TP53
14
Interleukin-4 and 13 signaling 66
11.86 MMP9 TNF TP53
15
Fluid shear stress and atherosclerosis 37
11.81 MMP9 SUMO1 TNF TP53
16
BRCA1 Pathway 64
Show member pathways
 11.7 HDAC2 MSH2 TP53
17
Spinal Cord Injury 1
11.7 APEX1 MMP9 TNF TP53
18
Glucocorticoid receptor regulatory network 1
11.68 HDAC2 MDM2 TP53
19
SMAD Signaling Network 64
11.64 APEX1 HDAC2 MDM2 SUMO1 TP53
20
Bladder cancer 37 1
11.62 MDM2 MMP9 TP53
21
Platinum drug resistance 37
11.62 MDM2 MSH2 TP53
22
Signaling events mediated by HDAC Class I 1
11.56 HDAC2 SUMO1 TNF
23
HIF1Alpha Pathway 64
11.46 APEX1 MDM2 TP53
24
Proteolysis Putative SUMO-1 pathway 22
Show member pathways
 11.44 MDM2 SUMO1 TP53
25
Integrated Cancer Pathway 1
11.32 MDM2 MSH2 TP53
26
Oncogene Induced Senescence 66
11.16 MDM2 TP53
27
Aurora A signaling 1
11.14 MDM2 TP53
28
Direct p53 effectors 1
11.14 HDAC2 MDM2 MSH2 SERPINB5 TP53
29
Transcription_P53 signaling pathway 22
11.09 APEX1 HDAC2 MDM2 SUMO1 TP53
30
Inhibition of Ribosome Biogenesis by p14(ARF) 64
10.98 MDM2 TP53
31
TP53 Network 1
Show member pathways
 10.78 MDM2 SUMO1 TP53
32
Sumoylation by RanBP2 regulates transcriptional repression 1
10.66 MDM2 SUMO1
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GO Terms for Cheilitis

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Biological processes related to Cheilitis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.84 HDAC2 MDM2 MMP9 TP53
2 extracellular matrix organization GO:0030198 9.73 MMP9 SERPINB5 TNF
3 negative regulation of transcription by RNA polymerase II GO:0000122 9.72 HDAC2 MDM2 SUMO1 TNF TP53
4 negative regulation of transcription, DNA-templated GO:0045892 9.65 HDAC2 MDM2 SUMO1 TNF TP53
5 negative regulation of DNA binding GO:0043392 9.57 HDAC2 SUMO1
6 response to antibiotic GO:0046677 9.55 MDM2 TP53
7 cellular response to gamma radiation GO:0071480 9.52 MDM2 TP53
8 positive regulation of release of cytochrome c from mitochondria GO:0090200 9.51 MMP9 TP53
9 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.49 MSH2 TP53
10 positive regulation of protein complex assembly GO:0031334 9.48 SUMO1 TNF
11 morphogenesis of an epithelium GO:0002009 9.46 KRT6A SERPINB5
12 cellular response to peptide hormone stimulus GO:0071375 9.43 APEX1 MDM2
13 positive regulation of protein export from nucleus GO:0046827 9.4 MDM2 TP53
14 determination of adult lifespan GO:0008340 9.37 MSH2 TP53
15 cellular response to hydrogen peroxide GO:0070301 9.33 APEX1 HDAC2 MDM2
16 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.13 MDM2 MMP9 TNF
17 cellular response to actinomycin D GO:0072717 8.62 MDM2 TP53

Molecular functions related to Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.9 APEX1 CAST HDAC2 KRT6A MDM2 MMP9
2 NF-kappaB binding GO:0051059 9.32 APEX1 HDAC2
3 SUMO transferase activity GO:0019789 9.26 MDM2 SUMO1
4 protease binding GO:0002020 9.13 CAST TNF TP53
5 enzyme binding GO:0019899 9.02 HDAC2 MDM2 MSH2 SUMO1 TP53
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Sources for Cheilitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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