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MCID: CHL056
MIFTS: 48

Cheilitis

Categories: Oral diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cheilitis

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MalaCards integrated aliases for Cheilitis:

Name: Cheilitis 12 29 43 15

Classifications:

MalaCards categories:
Anatomical: Oral diseases Skin diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1762
MeSH 43 D002613
NCIt 49 C79545
SNOMED-CT 67 7847004
ICD10 32 K13.0
UMLS 71 C0007971
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Summaries for Cheilitis

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Disease Ontology : 12 A lip disease characterized by the inflammation of the lips; which may include the perioral skin, the vermilion border and the labial mucosa.

MalaCards based summary : Cheilitis is related to peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads and actinic cheilitis. An important gene associated with Cheilitis is CAST (Calpastatin), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Isotretinoin and Salicylic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, b cells and t cells, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and Increased viability with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Cheilitis is inflammation of the lips. This inflammation may include the perioral skin (the skin around... more...

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Related Diseases for Cheilitis

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Diseases related to Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 432)
# Related Disease Score Top Affiliating Genes
1 peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads 34.8 ERAP1 CAST
2 actinic cheilitis 33.1 TP53 MSH2 MDM2 CDKN1A BCL2 APEX1
3 lip cancer 31.0 TP53 MSH2 MDM2 CDKN1A
4 lichen planus 30.8 TP53 TNF CD1A
5 squamous cell carcinoma 30.3 TP53 STAT3 MMP9 FGFR3 CDKN1A
6 anal fistula 30.2 TNF MSH2 MMP9
7 crohn's disease 30.1 TNF STAT3 CD4 CCR6
8 dermatitis 30.0 TNF STAT3 CSF2 CCR6
9 suppressor of tumorigenicity 3 30.0 TP53 CDKN1A BCL2
10 sialadenitis 29.8 TNF CD4 CCR6
11 severe cutaneous adverse reaction 29.6 TNF PDCD1 CD4
12 histiocytosis 29.5 TNF CSF2 CD1A CCR6
13 pyoderma 29.5 TNF MMP9 CCR6
14 allergic hypersensitivity disease 29.4 TNF CSF2 CD4 CCR6
15 skin carcinoma 29.2 TP53 MSH2 CSF2 CD274 CCR6
16 leprosy 3 29.2 TNF CSF2 CD4 CCR6
17 salivary gland disease 29.1 TP53 TNF CD4 CCR6
18 common cold 29.0 TNF CSF2 CD4 CCR6
19 mycobacterium tuberculosis 1 28.9 TNF CD4 CD1A CCR6
20 syphilis 28.8 CD4 CCR6 BCL2
21 basal cell carcinoma 28.8 TP53 TNF STAT3 MSH2 MMP9 MDM2
22 skin disease 28.8 TNF KRT6A CSF2 CD4 CD1A CCR6
23 vitiligo-associated multiple autoimmune disease susceptibility 1 28.7 PDCD1 CD4 CD274 CCR6
24 inflammatory bowel disease 28.6 TP53 TNF STAT3 MMP9 ERAP1 CSF2
25 exanthem 28.5 TNF PDCD1 CSF2 CD4 CD274 CCR6
26 dermatitis, atopic 28.5 TNF STAT3 CSF2 CD4 CCR6
27 acute promyelocytic leukemia 28.5 TNF STAT3 CSF2 CDKN1A BCL2
28 autoimmune disease 28.3 TNF STAT3 PDCD1 MMP9 CSF2 CCR6
29 systemic lupus erythematosus 27.2 TNF STAT3 PDCD1 MMP9 CSF2 CD4
30 lymphoma, non-hodgkin, familial 26.9 TP53 TNF STAT3 MSH2 MDM2 MALT1
31 myeloma, multiple 26.0 TP53 TNF STAT3 MMP9 MDM2 FGFR3
32 angular cheilitis 12.7
33 cheilitis glandularis 12.7
34 melkersson-rosenthal syndrome 12.2
35 orofacial granulomatosis 11.6
36 actinic prurigo 11.5
37 glucagonoma 11.5
38 ectodermal dysplasia/skin fragility syndrome 11.2
39 immunodeficiency 12 11.2
40 ichthyosis follicularis atrichia photophobia syndrome 11.2
41 plummer vinson syndrome 11.2
42 ring chromosome 7 10.6 TP53 MDM2
43 keratosis 10.6
44 esophagus verrucous carcinoma 10.5 TP53 MDM2
45 actinic keratosis 10.5
46 facial paralysis 10.4
47 bone giant cell sarcoma 10.4 TP53 MDM2
48 juvenile ankylosing spondylitis 10.4 TNF ERAP1
49 breast implant-associated anaplastic large cell lymphoma 10.4 TP53 STAT3
50 contact dermatitis 10.4

Graphical network of the top 20 diseases related to Cheilitis:



Diseases related to Cheilitis
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Symptoms & Phenotypes for Cheilitis

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GenomeRNAi Phenotypes related to Cheilitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.26 CSF2 MSH2 PDCD1 TNF
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.1 APEX1 BCL2 CDKN1A MDM2 MSH2 TP53

MGI Mouse Phenotypes related to Cheilitis:

45 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.47 BCL2 CAST CCR6 CD274 CD4 CDKN1A
2 cellular MP:0005384 10.46 APEX1 BCL2 CAST CD274 CD4 CDKN1A
3 immune system MP:0005387 10.46 APEX1 BCL2 CAST CCR6 CD274 CD4
4 homeostasis/metabolism MP:0005376 10.43 APEX1 BCL2 CAST CCR6 CD274 CD4
5 cardiovascular system MP:0005385 10.37 APEX1 BCL2 CAST CCR6 CDKN1A CSF2
6 growth/size/body region MP:0005378 10.36 APEX1 BCL2 CD4 CDKN1A CSF2 ERAP1
7 mortality/aging MP:0010768 10.36 APEX1 BCL2 CAST CD274 CD4 CDKN1A
8 integument MP:0010771 10.31 BCL2 CAST CD274 CD4 CDKN1A CSF2
9 endocrine/exocrine gland MP:0005379 10.3 APEX1 BCL2 CD4 CDKN1A CSF2 ERAP1
10 digestive/alimentary MP:0005381 10.27 BCL2 CD4 CDKN1A FGFR3 MDM2 MMP9
11 nervous system MP:0003631 10.21 BCL2 CAST CCR6 CD4 CDKN1A CSF2
12 craniofacial MP:0005382 10.18 BCL2 CDKN1A CSF2 FGFR3 MDM2 STAT3
13 neoplasm MP:0002006 10.18 APEX1 BCL2 CDKN1A CSF2 FGFR3 MDM2
14 muscle MP:0005369 10.09 APEX1 BCL2 CDKN1A MDM2 MMP9 PDCD1
15 limbs/digits/tail MP:0005371 10.02 CAST CDKN1A FGFR3 MDM2 MMP9 TNF
16 renal/urinary system MP:0005367 9.96 BCL2 CDKN1A CSF2 ERAP1 FGFR3 MDM2
17 no phenotypic analysis MP:0003012 9.92 CD274 CD4 CDKN1A ERAP1 FGFR3 MDM2
18 reproductive system MP:0005389 9.85 APEX1 BCL2 CDKN1A CSF2 FGFR3 MDM2
19 respiratory system MP:0005388 9.56 CDKN1A CSF2 FGFR3 MMP9 PDCD1 STAT3
20 skeleton MP:0005390 9.36 CAST CD274 CDKN1A CSF2 FGFR3 MDM2
Sources

Drugs & Therapeutics for Cheilitis

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Drugs for Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isotretinoin Approved Phase 4 4759-48-2 5538 5282379
2
Salicylic acid Approved, Investigational, Vet_approved Phase 4 69-72-7 338
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4
Ciclopirox Approved, Investigational Phase 4 29342-05-0 2749
5
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
6
Aminolevulinic acid Approved Phase 4 106-60-5 137
7 Analgesics Phase 4
8 Anti-Inflammatory Agents Phase 4
9 Anti-Infective Agents Phase 4
10 Salicylates Phase 4
11 Analgesics, Non-Narcotic Phase 4
12 Cyclooxygenase Inhibitors Phase 4
13 Anti-Inflammatory Agents, Non-Steroidal Phase 4
14 Keratolytic Agents Phase 4
15 Antifungal Agents Phase 4
16 Antirheumatic Agents Phase 4
17 Adjuvants, Immunologic Phase 4
18 Methyl 5-aminolevulinate Phase 4
19 Immunologic Factors Phase 4
20 Interferon Inducers Phase 4
21 interferons Phase 4
22 Dermatologic Agents Phase 4
23 Photosensitizing Agents Phase 4
24
Chitosan Experimental Phase 2 9012-76-4 71853
25 Protective Agents Phase 2
26 Sunscreening Agents Phase 2
27 Radiation-Protective Agents Phase 2
28 Terephthalylidene dicamphor sulfonic acid Phase 2
29 Hypolipidemic Agents Phase 2
30 Anticholesteremic Agents Phase 2
31 Chelating Agents Phase 2
32 Hemostatics Phase 2
33 Coagulants Phase 2
34 Lipid Regulating Agents Phase 2
35 Antimetabolites Phase 2
36
Lidocaine Approved, Vet_approved Phase 1 137-58-6 3676
37
Prilocaine Approved Phase 1 721-50-6 4906
38 Anesthetics, Local Phase 1
39 Anti-Arrhythmia Agents Phase 1
40 Anesthetics Phase 1
41 Sodium Channel Blockers Phase 1
42 Lidocaine, Prilocaine Drug Combination Phase 1
43 Central Nervous System Depressants Phase 1
44 Diuretics, Potassium Sparing Phase 1

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Clinical, Laboratorial and Quality of Life Trial to Evaluate the Efficacy and Safety of Low-dose Oral Isotretinoin for Seborrhea. Unknown status NCT01139749 Phase 4 oral isotretinoin;salicylic acid and ciclopirox olamine
2 Randomized Prospective Study Comparing 5% Imiquimod and Photodynamic Therapy for Actinic Cheilitis Completed NCT00849992 Phase 4 Imiquimod 5%
3 Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis Completed NCT02409732 Phase 4 aminolevulinic acid hydrochloride
4 A Clinical Trial of ALA Photodynamic Therapy for Treatment of Actinic Cheilitis in Patients With Squamous Cell Carcinoma of the Lip. Completed NCT00868088 Phase 4
5 Phase II Randomized Controlled Trial to Evaluate the Clinical and Histological Effects of Oral Isotretinoin for the Treatment of Photoaging on Face and Forearms Completed NCT00701740 Phase 2 oral isotretinoin and Mexoryl SX / XL;Mexoryl XL / SX
6 A Randomized Controlled Trial of the Efficacy and Safety of a a Biofunctional Textile in the Management of Atopic Dermatitis Completed NCT01597817 Phase 2
7 Photodynamic Therapy With Metil 5-aminolevulinate for Actinic Cheilitis - A Phase 2 Randomized Double-blind Placebo Controlled Clinical Trial Not yet recruiting NCT03990636 Phase 2 Metil 5-aminolevulinate
8 Phase 1/2 Clinical Trial for the Evaluation of Ingenol Mebutate for Actinic Cheilitis Withdrawn NCT03452566 Phase 1, Phase 2 Ingenol mebutate gel
9 A Randomized, Prospective Study Comparing Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Ablative Fractional Laser Treatment for Actinic Cheilitis Completed NCT02198469 Phase 1 Er:YAG AFL-PDT;MAL-PDT
10 Efficacy of Iontophoresis-assisted Ablative Fractional Laser Photodynamic Therapy With Short Incubation Time for the Treatment of Actinic Keratosis: 12-month Follow-up Results of a Prospective, Randomised, Comparative Trial Completed NCT02670655 Phase 1 lidocaine/prilocaine (5%) application;MAL application
11 A Randomised Trial Comparing Methyl Aminolaevulinate Photodynamic Therapy With and Without Ablative Fractional Laser Treatment in Patients With Microinvasive Squamous Cell Carcinoma: Results From a 24-month Follow-up Completed NCT02666534 Phase 1 lidocaine-prilocaine 5% cream application;methyl-aminolevulinate application
12 Acute Abdomen in Kawasaki Disease: Case Reports Completed NCT03902262
13 Actinic Cheilitis Pre-Treated With DNA Repair Enzyme Cream Withdrawn NCT03224715

Search NIH Clinical Center for Cheilitis

Cochrane evidence based reviews: cheilitis

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Genetic Tests for Cheilitis

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Genetic tests related to Cheilitis:

# Genetic test Affiliating Genes
1 Cheilitis 29
Sources

Anatomical Context for Cheilitis

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MalaCards organs/tissues related to Cheilitis:

40
Skin, B Cells, T Cells, Breast, Lung, Bone, Salivary Gland
Sources

Publications for Cheilitis

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Articles related to Cheilitis:

(show top 50) (show all 1537)
# Title Authors PMID Year
1
Cheilitis with hemorrhagic crusts of the vermilion lips. 61
32010965 2020
2
Interventions for chronic palmoplantar pustulosis. 61
31958161 2020
3
5-aminolevulinic acid patch (Alacare) PDT for actinic cheilitis: data from a prospective 12-month follow-up study on 21 patients. 61
31999856 2020
4
Temporomandibular Disorders and Oral Features in Systemic Lupus Erythematosus Patients: An Observational Study of Symptoms and Signs. 61
32038098 2020
5
Oral potentially malignant disorders: clinical-pathological study of 684 cases diagnosed in a Brazilian population. 61
31880285 2020
6
Chapter 6: Vitamins and Oral Health. 61
31940621 2020
7
Actinic cheilitis: Morphometric parameters and its relationship with the degree of epithelial dysplasia. 61
31558280 2020
8
Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis. 61
31880283 2020
9
Detection of human papillomaviruses and human polyomaviruses in immunosuppressed and immunocompetent individuals with actinic cheilitis: a case series. 61
31281986 2019
10
Herpes simplex reactivation after photodynamic therapy for actinic cheilitis in a patient with non-Hodgkin lymphoma: a possible indication for prophylaxis. 61
29512976 2019
11
Proper management of suspicious actinic cheilitis. 61
31032237 2019
12
Effects of Electronic Cigarettes on Oral Cavity: A Systematic Review. 61
31843181 2019
13
Efficacy of vedolizumab in granulomatous cheilitis refractory to TNFα inhibitors. 61
31498875 2019
14
Lip Smacker's Cheilitis. 61
31884455 2019
15
High rate of clinical improvement of actinic cheilitis with laser, surgery, and chemotherapeutic agents in patients who have a favorable prognosis. 61
31519297 2019
16
Patch Testing for Cheilitis: A 10-Year Series. 61
31609855 2019
17
Characteristics of the salivary microbiota in cheilitis granulomatosa. 61
31655830 2019
18
Isotretinoin-induced pruritic erythematous lesions and acute chest pain in a 15-year-old girl. 61
31784393 2019
19
A novel homozygous nonsense mutation in CAST associated with PLACK syndrome. 61
31392520 2019
20
Hold the spice: Allergy to garlic and sulfites-Possible relevance in a patient with cheilitis granulomatosa. 61
31237355 2019
21
Diarrhea: a missed D in the 4D glucagonoma syndrome. 61
31807436 2019
22
Fludroxycortide cream as an alternative therapy for actinic cheilitis. 61
30673866 2019
23
Successful treatment of cheilitis granulomatosa with lenalidomide. 61
31063601 2019
24
Denture stomatitis associated with small-colony variants of Staphylococcus aureus: a case report. 61
31604449 2019
25
Cutaneous candidiasis - an evidence-based review of topical and systemic treatments to inform clinical practice. 61
31287594 2019
26
Digital scanning for implant-supported fixed complete-arch dental prostheses for patients with epidermolysis bullosa: A case series evaluation. 61
31079885 2019
27
An oral manifestation of IBD: Pyostomatitis vegetant, about two cases. 61
31035024 2019
28
Intralesional Steroids for the Management of Periorificial Granulomatous Dermatitis 61
31524997 2019
29
Unsuccessful Treatment of Cheilitis Granulomatosa with Oral Methotrexate. 61
31616277 2019
30
Actinic Cheilitis: Analysis of Clinical Subtypes, Risk Factors and Associated Signs of Actinic Damage. 61
31197386 2019
31
Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis. 61
31066083 2019
32
Combined zinc and vitamin B6 deficiency in a patient with diffuse red rash and angular cheilitis 6 years after Roux-en-Y gastric bypass. 61
31377720 2019
33
Treatment of angular cheilitis: A narrative review and authors' clinical experience. 61
31464357 2019
34
Oral and Otorhinolaryngological Findings in Adults Who Were Diagnosed With Pediatric Onset Crohn's Disease: A Controlled Study. 61
29912762 2019
35
[Study on the oral mucosal diseases in patients with cerebrovascular diseases]. 61
31484269 2019
36
Immunoexpression of human leukocyte antigen-DR in actinic cheilitis and lower lip squamous cell carcinoma. 61
31483051 2019
37
Use of lip photoprotection in patients suffering from actinic cheilitis. 61
31475909 2019
38
Treatments of actinic cheilitis: A systematic review of the literature. 61
31400450 2019
39
Prevalence of Oral Lesions and Correlation with Intestinal Symptoms of Inflammatory Bowel Disease: A Systematic Review. 61
31311171 2019
40
Lymphoplasmacytic Granulomatosis Cheilitis Treated with Cheiloplasty. 61
31360289 2019
41
DNA Repair Enzyme Containing Lip Balm for the Treatment of Actinic Cheilitis: A Pilot Study 61
31251551 2019
42
Ointment Pseudo-Cheilitis: A Disease Distinct From Factitial Cheilitis. A Series of 13 Patients From São Paulo, Brazil. 61
30654637 2019
43
Surgical versus non-surgical treatment of actinic cheilitis: A systematic review and meta-analysis. 61
29908101 2019
44
Propylthiouracil-induced anti-neutrophil cytoplasmic antibody-associated vasculitis mimicking Kawasaki disease. 61
29457989 2019
45
Treatment of actinic cheilitis: a systematic review. 61
31011833 2019
46
Analysis of risk factors for maxillary denture-related oral mucosal lesions: A cross-sectional study. 61
31011141 2019
47
Cheilitis granulomatosa and Crohn's disease : a case report. 61
31314197 2019
48
Plasma cell cheilitis: the diagnosis of a disorder mimicking lip cancer. 61
30963053 2019
49
Ingenol mebutate versus imiquimod versus diclofenac for actinic cheilitis: a 6-month follow-up clinical study. 61
30242791 2019
50
Risk factors associated with oral manifestations and oral health impact of gastro-oesophageal reflux disease: a multicentre, cross-sectional study in Pakistan. 61
30928919 2019
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Variations for Cheilitis

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Expression for Cheilitis

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Search GEO for disease gene expression data for Cheilitis.
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Pathways for Cheilitis

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Pathways related to Cheilitis according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 63
Show member pathways
 13.85 TP53 TNF STAT3 MDM2 FGFR3 CSF2
2
PEDF Induced Signaling 63
Show member pathways
 13.71 TP53 TNF STAT3 FGFR3 CSF2 CDKN1A
3
Class I MHC mediated antigen processing and presentation 65
Show member pathways
 13.46 TP53 PDCD1 MDM2 MALT1 FGFR3 ERAP1
4
Akt Signaling 63
Show member pathways
 13.4 TP53 TNF STAT3 MDM2 FGFR3 CSF2
5
Cytokine Signaling in Immune system 65
Show member pathways
 13.37 TP53 TNF STAT3 MMP9 FGFR3 CSF2
6
Toll-like Receptor Signaling Pathway 1 36
Show member pathways
 13.15 TP53 TNF STAT3 MMP9 CDKN1A BCL2
7
Innate Immune System 65
Show member pathways
 13.12 TP53 TNF STAT3 PDCD1 MMP9 MDM2
8
PI3K-Akt signaling pathway 36
Show member pathways
 13.01 TP53 TNF MDM2 FGFR3 CDKN1A BCL2
9
TNFR1 Pathway 63
Show member pathways
 12.98 TP53 TNF MMP9 ERAP1 CDKN1A CD4
10
Human cytomegalovirus infection 36
Show member pathways
 12.94 TP53 TNF STAT3 MDM2 CSF2 CDKN1A
11
Endometrial cancer 36
Show member pathways
 12.86 TP53 STAT3 MSH2 MMP9 MDM2 CSF2
12
Measles 36
Show member pathways
 12.85 TP53 TNF STAT3 MDM2 CDKN1A BCL2
13
Apoptosis Modulation and Signaling 1
Show member pathways
 12.84 TP53 TNF MDM2 CDKN1A BCL2
14
Pathways in cancer 36
12.8 TP53 STAT3 MSH2 MMP9 MDM2 FGFR3
15
Downstream signaling events of B Cell Receptor (BCR) 65
Show member pathways
 12.76 TP53 MDM2 MALT1 FGFR3 CDKN1A
16
Chks in Checkpoint Regulation 63
Show member pathways
 12.73 TP53 MSH2 MDM2 CDKN1A BCL2 APEX1
17
Glioma 36
Show member pathways
 12.71 TP53 STAT3 MMP9 MDM2 CDKN1A BCL2
18
ErbB signaling pathway 1 36
Show member pathways
 12.65 TP53 STAT3 MDM2 FGFR3 CDKN1A BCL2
19
T cell receptor signaling pathway 36
Show member pathways
 12.61 TNF STAT3 PDCD1 MALT1 CSF2 CD4
20
NF-kappaB Signaling 4
12.59 TNF STAT3 PDCD1 MALT1 CD274 APEX1
21
Immune response IL-23 signaling pathway 22
Show member pathways
 12.57 TP53 TNF STAT3 MSH2 CDKN1A CD4
22
DNA Damage 4
12.54 TP53 MSH2 MDM2 CDKN1A APEX1
23
Development IGF-1 receptor signaling 22
Show member pathways
 12.42 TP53 STAT3 MDM2 CDKN1A
24
DNA Damage Response 1
Show member pathways
 12.4 TP53 MDM2 CDKN1A BCL2
25
MicroRNAs in cancer 36
12.4 TP53 STAT3 MMP9 MDM2 FGFR3 CDKN1A
26
Human T-cell leukemia virus 1 infection 36
12.38 TP53 TNF CSF2 CDKN1A CD4
27
IL-17 Family Signaling Pathways 64
Show member pathways
 12.36 TNF STAT3 MMP9 CSF2
28
JAK-STAT signaling pathway (KEGG) 36
Show member pathways
 12.36 STAT3 CSF2 CDKN1A BCL2
29
Viral carcinogenesis 36
12.32 TP53 STAT3 MDM2 CDKN1A
30
Proteoglycans in cancer 36
12.32 TP53 TNF STAT3 MMP9 MDM2 CDKN1A
31
Transcriptional misregulation in cancer 36
12.29 TP53 MMP9 MDM2 CSF2 CDKN1A
32
p53 Signaling 63
Show member pathways
 12.28 TP53 MDM2 CDKN1A BCL2
33
MAPK Signaling: Mitogen Stimulation Pathway 64
Show member pathways
 12.26 TP53 MDM2 FGFR3 CDKN1A BCL2
34
Integrated Breast Cancer Pathway 1
12.18 TP53 MSH2 MDM2 BCL2
35
Shigellosis 36
12.17 TP53 TNF MDM2 MALT1 CSF2 CAST
36
Fluid shear stress and atherosclerosis 36
12.13 TP53 TNF MMP9 BCL2
37
Direct p53 effectors 1
12.09 TP53 MSH2 MDM2 CDKN1A BCL2
38
Spinal Cord Injury 1
12.05 TP53 TNF MMP9 APEX1
39
DNA Damage Response (only ATM dependent) 1
12.03 TP53 MDM2 CDKN1A BCL2
40
Colorectal Cancer Metastasis 63
12.02 TP53 TNF STAT3 MSH2 MMP9 CDKN1A
41
Senescence and Autophagy in Cancer 1
11.98 TP53 MDM2 CDKN1A BCL2
42
Hematopoietic cell lineage 36
11.95 TNF CSF2 CD4 CD1A
43
Glucocorticoid receptor regulatory network 1
11.85 TP53 MDM2 CSF2 CDKN1A
44
Innate Lymphoid Cell Differentiation Pathways 64
11.81 TNF CD4 CCR6
45
C-MYB transcription factor network 1
11.8 CDKN1A CD4 BCL2
46
Dendritic Cells Developmental Lineage Pathway 64
11.8 TNF CSF2 CD4 CD1A
47
CXCR4-mediated signaling events 1
11.79 STAT3 MMP9 CD4
48
NF-kB (NFkB) Pathway 66
11.76 TNF MALT1 CD4
49
Microglia Activation During Neuroinflammation: Microglia Polarization 64
11.75 TNF MMP9 CSF2
50
Transcription_P53 signaling pathway 22
11.74 TP53 MDM2 CDKN1A BCL2 APEX1
Sources

GO Terms for Cheilitis

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Cellular components related to Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.1 TNF PDCD1 CD4 CD274 CD1A CCR6

Biological processes related to Cheilitis according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 10.06 TP53 MSH2 CDKN1A BCL2 APEX1
2 positive regulation of gene expression GO:0010628 10.05 TP53 TNF STAT3 MDM2 CSF2
3 positive regulation of cell proliferation GO:0008284 10.01 STAT3 MDM2 KRT6A FGFR3 CSF2 BCL2
4 adaptive immune response GO:0002250 9.97 PDCD1 ERAP1 CD4 CD274 CD1A
5 immune response GO:0006955 9.97 TNF CSF2 CD4 CD274 CD1A CCR6
6 regulation of cell proliferation GO:0042127 9.94 TP53 TNF STAT3 CSF2
7 regulation of cell cycle GO:0051726 9.88 TP53 STAT3 CDKN1A BCL2
8 cellular response to organic cyclic compound GO:0071407 9.82 TNF STAT3 MDM2
9 response to glucocorticoid GO:0051384 9.82 TNF CDKN1A BCL2
10 positive regulation of protein kinase activity GO:0045860 9.81 TNF CDKN1A CD4
11 response to cytokine GO:0034097 9.8 STAT3 CD274 BCL2
12 response to drug GO:0042493 9.8 TP53 STAT3 MDM2 CDKN1A BCL2 APEX1
13 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.79 TP53 MDM2 CDKN1A
14 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.78 TNF MSH2 BCL2
15 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.77 TNF MMP9 MDM2
16 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.73 TNF CSF2 BCL2
17 negative regulation of mitotic cell cycle GO:0045930 9.72 TP53 TNF BCL2
18 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 TNF STAT3 FGFR3 CSF2
19 cellular response to gamma radiation GO:0071480 9.69 TP53 MDM2 CDKN1A
20 humoral immune response GO:0006959 9.67 TNF PDCD1 CCR6 BCL2
21 positive regulation of programmed cell death GO:0043068 9.66 TNF CDKN1A
22 response to salt stress GO:0009651 9.66 TP53 TNF
23 cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 9.65 CSF2 CD4
24 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.65 TP53 MSH2 CDKN1A
25 response to X-ray GO:0010165 9.63 TP53 MSH2 CDKN1A
26 cellular response to UV-C GO:0071494 9.62 TP53 MDM2
27 T cell lineage commitment GO:0002360 9.61 TP53 BCL2
28 macrophage differentiation GO:0030225 9.61 MMP9 CSF2 CD4
29 signal transduction by p53 class mediator GO:0072331 9.59 TP53 CDKN1A
30 B cell lineage commitment GO:0002326 9.58 TP53 BCL2
31 negative regulation of apoptotic process GO:0043066 9.56 TP53 STAT3 PDCD1 MMP9 MDM2 MALT1
32 cellular response to actinomycin D GO:0072717 9.52 TP53 MDM2
33 regulation of mitochondrial membrane permeability GO:0046902 9.43 TP53 STAT3 BCL2
34 response to UV-B GO:0010224 9.33 TP53 MSH2 BCL2
35 cytokine-mediated signaling pathway GO:0019221 9.23 TP53 TNF STAT3 MMP9 CSF2 CDKN1A

Molecular functions related to Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.96 TP53 TNF STAT3 PDCD1 MSH2 MMP9
2 identical protein binding GO:0042802 9.81 TP53 TNF STAT3 MMP9 MDM2 MALT1
3 protein kinase binding GO:0019901 9.65 TP53 STAT3 MSH2 CDKN1A CD4
4 protease binding GO:0002020 9.02 TP53 TNF MALT1 CAST BCL2
Sources

Sources for Cheilitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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