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MCID: CHL056
MIFTS: 48

Cheilitis

Categories: Oral diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cheilitis

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MalaCards integrated aliases for Cheilitis:

Name: Cheilitis 12 30 45 15

Classifications:

MalaCards categories:
Anatomical: Oral diseases Skin diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:1762
MeSH 45 D002613
NCIt 51 C79545
SNOMED-CT 69 7847004
ICD10 34 K13.0
UMLS 74 C0007971
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Summaries for Cheilitis

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Disease Ontology : 12 A lip disease characterized by the inflammation of the lips; which may include the perioral skin, the vermilion border and the labial mucosa.

MalaCards based summary : Cheilitis is related to actinic cheilitis and glossitis. An important gene associated with Cheilitis is CAST (Calpastatin), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Aminolevulinic acid and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and breast, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and cellular

Wikipedia : 77 Cheilitis is inflammation of the lips. This inflammation may include the perioral skin (the skin around... more...

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Related Diseases for Cheilitis

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Diseases related to Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 actinic cheilitis 33.6 HDAC2 MDM2 MSH2 TP53
2 glossitis 30.3 KRT6A TNF
3 lip cancer 30.0 MDM2 MSH2 SUMO1 TP53
4 angular cheilitis 12.6
5 cheilitis glandularis 12.6
6 peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads 12.6
7 melkersson-rosenthal syndrome 12.0
8 orofacial granulomatosis 11.5
9 actinic prurigo 11.4
10 glucagonoma 11.4
11 ectodermal dysplasia/skin fragility syndrome 11.0
12 immunodeficiency 12 11.0
13 ichthyosis follicularis atrichia photophobia syndrome 11.0
14 plummer vinson syndrome 11.0
15 crohn's disease 10.5
16 squamous cell carcinoma 10.5
17 ring chromosome 7 10.3 MDM2 TP53
18 zika virus infection 10.3 MDM2 TP53
19 dermatitis 10.3
20 sclerosing liposarcoma 10.3 MDM2 TP53
21 sapho syndrome 10.3 MDM2 TP53
22 periosteal osteogenic sarcoma 10.3 MDM2 TP53
23 gliomatosis cerebri 10.3 MDM2 TP53
24 dedifferentiated liposarcoma 10.3 MDM2 TP53
25 small cell sarcoma 10.3 MDM2 TP53
26 myxosarcoma 10.3 MDM2 TP53
27 verrucous carcinoma 10.2 MDM2 TP53
28 embryonal sarcoma 10.2 MDM2 TP53
29 vulvitis 10.2
30 stomatitis 10.2
31 cardia cancer 10.2 MDM2 TP53
32 brain glioblastoma multiforme 10.2 MMP9 TP53
33 anal fistula 10.2 MMP9 MSH2
34 middle ear carcinoma 10.2 CD1A MMP9
35 cerebral primitive neuroectodermal tumor 10.2 MSH2 TP53
36 pigmented villonodular synovitis 10.2 MMP9 TP53
37 contact dermatitis 10.2
38 gingivitis 10.2
39 thyroid lymphoma 10.1 TNF TP53
40 leishmaniasis 10.1
41 lichen planus 10.1
42 chronic salpingitis 10.1 TNF TP53
43 angioedema 10.1
44 iron metabolism disease 10.1
45 allergic contact dermatitis 10.1
46 periodontitis 10.1
47 lupus erythematosus 10.1
48 grade iii astrocytoma 10.0 MDM2 MMP9 TP53
49 skin melanoma 10.0 MDM2 MMP9 TP53
50 autoimmune inner ear disease 10.0 MMP9 TNF

Graphical network of the top 20 diseases related to Cheilitis:



Diseases related to Cheilitis
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Symptoms & Phenotypes for Cheilitis

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GenomeRNAi Phenotypes related to Cheilitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 HDAC2 MDM2 MSH2 SUMO1 TP53

MGI Mouse Phenotypes related to Cheilitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.06 CAST HDAC2 MDM2 MMP9 MSH2 SERPINB5
2 hematopoietic system MP:0005397 9.92 CAST HDAC2 MDM2 MMP9 MSH2 SERPINB5
3 digestive/alimentary MP:0005381 9.91 HDAC2 MDM2 MMP9 MSH2 SUMO1 TNF
4 integument MP:0010771 9.8 CAST HDAC2 MDM2 MMP9 MSH2 TNF
5 limbs/digits/tail MP:0005371 9.63 CAST HDAC2 MDM2 MMP9 TNF TP53
6 mortality/aging MP:0010768 9.61 CAST HDAC2 MDM2 MMP9 MSH2 SERPINB5
7 neoplasm MP:0002006 9.1 HDAC2 MDM2 MMP9 MSH2 TNF TP53
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Drugs & Therapeutics for Cheilitis

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Drugs for Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 4,Phase 1 106-60-5 137
2
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
3 Dermatologic Agents Phase 4,Phase 2,Phase 1
4 Photosensitizing Agents Phase 4,Phase 1
5 Adjuvants, Immunologic Phase 4
6 Immunologic Factors Phase 4,Phase 2
7 interferons Phase 4
8 Methyl 5-aminolevulinate Phase 4,Phase 1
9 Interferon Inducers Phase 4
10
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
11
Infliximab Approved Phase 2 170277-31-3
12
Tacrolimus Approved, Investigational Phase 2 104987-11-3 6473866 445643 439492
13
Isotretinoin Approved Phase 2 4759-48-2 5282379 5538
14
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 444795 5538
15 Antibodies, Monoclonal Phase 2
16 Immunoglobulins Phase 2
17 Gastrointestinal Agents Phase 2
18 Antibodies Phase 2
19 Antirheumatic Agents Phase 2
20 Immunosuppressive Agents Phase 2
21 Calcineurin Inhibitors Phase 2
22 Protective Agents Phase 2
23 Radiation-Protective Agents Phase 2
24 Keratolytic Agents Phase 2
25 Sunscreening Agents Phase 2

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis Completed NCT02409732 Phase 4 aminolevulinic acid hydrochloride
2 Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic Therapy Completed NCT00849992 Phase 4 Imiquimod 5%
3 Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the Lip Completed NCT00868088 Phase 4
4 Use of Infliximab for the Treatment of Pemphigus Vulgaris Completed NCT00283712 Phase 2 Infliximab
5 Topical Tacrolimus 0.1% Ointment For Treatment Of Cutaneous Crohn's Disease Completed NCT01233570 Phase 2 Tacrolimus
6 Oral Isotretinoin Versus Topical Tretinoin for Actinic Keratosis Completed NCT02278861 Phase 2 Oral isotretinoin;Tretinoin 0,05% cream;Sunscreen FPS 60
7 Evaluation of Ingenol Mebutate for Actinic Cheilitis Treatment Not yet recruiting NCT03452566 Phase 1, Phase 2 Ingenol mebutate gel
8 Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Actinic Cheilitis Completed NCT02198469 Phase 1 Er:YAG AFL-PDT;MAL-PDT
9 Dental Hygienist Support Promotes Good Oral Health in Nursing Homes Completed NCT02676453 Not Applicable
10 Periodontal Outcomes After Sanative Therapy Enrolling by invitation NCT03649789
11 Actinic Cheilitis Pre-Treated With DNA Repair Enzyme Cream Withdrawn NCT03224715 Not Applicable

Search NIH Clinical Center for Cheilitis

Cochrane evidence based reviews: cheilitis

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Genetic Tests for Cheilitis

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Genetic tests related to Cheilitis:

# Genetic test Affiliating Genes
1 Cheilitis 30
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Anatomical Context for Cheilitis

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MalaCards organs/tissues related to Cheilitis:

42
Skin, Testes, Breast, Salivary Gland, T Cells, Tongue, Bone
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Publications for Cheilitis

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Articles related to Cheilitis:

(show top 50) (show all 613)
# Title Authors Year
1
Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis. ( 31066083 )
2019
2
Successful treatment of cheilitis granulomatosa with lenalidomide. ( 31063601 )
2019
3
Plasma cell cheilitis: the diagnosis of a disorder mimicking lip cancer. ( 30963053 )
2019
4
Cheilitis and gingivitis as first signs of Crohn's disease in a pediatric patient. ( 30847214 )
2019
5
Ointment Pseudo-Cheilitis: A Disease Distinct from Factitial Cheilitis. A Series of 13 Patients from São Paulo, Brazil. ( 30654637 )
2019
6
Proper management of suspicious actinic cheilitis. ( 31032237 )
2019
7
Treatment of actinic cheilitis: a systematic review. ( 31011833 )
2019
8
Actinic cheilitis and lip squamous cell carcinoma: Literature review and new data from Brazil. ( 30697396 )
2019
9
Fludroxycortide cream as an alternative therapy for actinic cheilitis. ( 30673866 )
2019
10
Ingenol mebutate versus imiquimod versus diclofenac for actinic cheilitis: a 6-month follow-up clinical study. ( 30242791 )
2019
11
Evidence regarding how surgical treatment of actinic cheilitis compares with nonsurgical treatment is not trustworthy and does not consider all important outcomes. ( 30119827 )
2019
12
Daylight photodynamic therapy for the treatment of actinic cheilitis. ( 30066408 )
2019
13
Recurrent angular cheilitis after secukinumab injections. ( 28620989 )
2018
14
The "Fresh Breath" on Toothpaste: Peppermint-Flavored Toothpaste as Cause of Cheilitis. ( 30570581 )
2018
15
Differential Diagnosis of Cheilitis - How to Classify Cheilitis? ( 30431729 )
2018
16
Devriesea agamarum associated cheilitis in a North African spiny-tailed lizard (Uromastyx acanthinura) in Spain. ( 30425957 )
2018
17
Rasch wachsende verruköse axilläre Tumoren, multiple Erosionen, Pusteln und Cheilitis. ( 30300479 )
2018
18
Rapidly growing verrucous axillary tumors, multiple erosions, pustules, and cheilitis. ( 30211479 )
2018
19
Allergic contact cheilitis caused by lauryl PCA. ( 30019410 )
2018
20
Cheilitis: An unusual presentation of Mucocutaneous Leishmaniasis. ( 29988622 )
2018
21
Exfoliative Cheilitis as a Manifestation of Factitial Cheilitis. ( 29974020 )
2018
22
A Systematic Review of the Literature of the Three Related Disease Entities Cheilitis Granulomatosa, Orofacial Granulomatosis and Melkersson - Rosenthal Syndrome. ( 29766816 )
2018
23
Allergic contact cheilitis in an adolescent to Ricinus communis seed oil (castor oil) in a lip balm. ( 29749619 )
2018
24
Cheilitis Glandularis of Both Lips: Successful Treatment with a Combination of an Intralesional Steroid Injection and Tacrolimus Ointment. ( 29744227 )
2018
25
Metronidazole as a monotherapy in the management of granulomatous cheilitis. ( 29667611 )
2018
26
Treating isotretinoin-associated cheilitis with hydrocortisone-containing lip balm. ( 29551370 )
2018
27
Evaluation the efficacy of trichloroacetic acid (TCA) 33% in treatment of oral retinoid-induced cheilitis compared with placebo (Vaseline): a randomized pilot study. ( 29464980 )
2018
28
A favorable response to omalizumab in a patient with cheilitis granulomatosa. ( 29426753 )
2018
29
Allergic Contact Cheilitis From a Variety of Lip Balm Ingredients. ( 29039219 )
2018
30
A Surprising Granulomatous Cheilitis. ( 28712755 )
2018
31
Angular cheilitis induced by iron deficiency anemia. ( 30102595 )
2018
32
Hyaluronic acid dermal fillers in the management of recurrent angular cheilitis: A case report. ( 29733533 )
2018
33
Actinic Cheilitis Prevalence and Risk Factors: A Cross-sectional, Multicentre Study in a Population Aged 45 Years and Over in North-west Spain. ( 30085328 )
2018
34
Immunoexpression of glucocorticoid receptor alpha (GRα) isoform and apoptotic proteins (Bcl-2 and Bax) in actinic cheilitis and lower lip squamous cell carcinoma. ( 29935090 )
2018
35
Surgical versus non-surgical treatment of actinic cheilitis: A systematic review and meta-analysis. ( 29908101 )
2018
36
Prevalence of and Factors Associated with Actinic Cheilitis in Extractive Mining Workers. ( 29898071 )
2018
37
Hyaluronic acid dermal fillers in the management of recurrent angular cheilitis: a case report. ( 30095087 )
2018
38
Malignant transformation of actinic cheilitis: A systematic review of observational studies. ( 29863311 )
2018
39
Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer. ( 29779037 )
2018
40
Expression of stem cell markers Nanog and Nestin in lip squamous cell carcinoma and actinic cheilitis. ( 29761881 )
2018
41
Evaluation of Cellular Proliferative Activity in Patients with Actinic Cheilitis through Silver-stained Nucleolar Organizer Region Method. ( 29728540 )
2018
42
Non-invasive imaging of actinic cheilitis and squamous cell carcinoma of the lip. ( 29725529 )
2018
43
Dermoscopy and reflectance confocal microscopy for monitoring the treatment of actinic cheilitis with ingenol mebutate gel: Report of three cases. ( 29687567 )
2018
44
Erratum: Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis: erratum. ( 29552401 )
2018
45
Herpes simplex reactivation after photodynamic therapy for actinic cheilitis in a patient with Non-Hodgkin Lymphoma: a possible indication for prophylaxis. ( 29512976 )
2018
46
Diclofenac sodium gel therapy as an alternative to actinic cheilitis. ( 28986686 )
2018
47
Can obstructive intralymphatic granulomas be the cause of cheilitis granulomatosa? ( 30234252 )
2017
48
Treatment of exfoliative cheilitis with Traditional Chinese Medicine: a systematic review. ( 29960285 )
2017
49
Erfolgreiche Behandlung einer Cheilitis granulomatosa mit Infliximab bei Kindern. ( 29228481 )
2017
50
Successful treatment of childhood cheilitis granulomatosa with infliximab. ( 28985456 )
2017
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Variations for Cheilitis

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Expression for Cheilitis

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Search GEO for disease gene expression data for Cheilitis.
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Pathways for Cheilitis

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Pathways related to Cheilitis according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Endometrial cancer 38
Show member pathways
 12.65 HDAC2 MDM2 MMP9 MSH2 TP53
2
Pathways in cancer 38
12.6 HDAC2 MDM2 MMP9 MSH2 TP53
3
Chks in Checkpoint Regulation 65
Show member pathways
 12.52 MDM2 MSH2 SUMO1 TP53
4
MicroRNAs in cancer 38
12.35 MDM2 MMP9 SERPINB5 TP53
5
Cell cycle 38 1
12.18 HDAC2 MDM2 TP53
6
Viral carcinogenesis 38
12.11 HDAC2 MDM2 TP53
7
p53 Signaling 65
Show member pathways
 12.08 HDAC2 MDM2 TP53
8
Proteoglycans in cancer 38
12.06 MDM2 MMP9 TNF TP53
9
Integrated Breast Cancer Pathway 1
11.98 MDM2 MSH2 TP53
10
Transcriptional misregulation in cancer 38
11.97 HDAC2 MDM2 MMP9 TP53
11
Spinal Cord Injury 1
11.86 MMP9 TNF TP53
12
Thyroid hormone signaling pathway 38
11.84 HDAC2 MDM2 TP53
13
Interleukin-4 and 13 signaling 67
11.82 MMP9 TNF TP53
14
Colorectal Cancer Metastasis 65
11.78 MMP9 MSH2 TNF TP53
15
SMAD Signaling Network 65
11.75 HDAC2 MDM2 SUMO1 TP53
16
BRCA1 Pathway 65
Show member pathways
 11.66 HDAC2 MSH2 TP53
17
Glucocorticoid receptor regulatory network 1
11.65 HDAC2 MDM2 TP53
18
Fluid shear stress and atherosclerosis 38
11.6 MMP9 SUMO1 TNF TP53
19
Bladder cancer 1 38
11.59 MDM2 MMP9 TP53
20
Platinum drug resistance 38
11.58 MDM2 MSH2 TP53
21
Signaling events mediated by HDAC Class I 1
11.52 HDAC2 SUMO1 TNF
22
Proteolysis Putative SUMO-1 pathway 23
Show member pathways
 11.4 MDM2 SUMO1 TP53
23
Transcription_P53 signaling pathway 23
11.36 HDAC2 MDM2 SUMO1 TP53
24
Integrated Cancer Pathway 1
11.27 MDM2 MSH2 TP53
25
Oncogene Induced Senescence 67
11.15 MDM2 TP53
26
Direct p53 effectors 1
11.14 HDAC2 MDM2 MSH2 SERPINB5 TP53
27
Aurora A signaling 1
11.13 MDM2 TP53
28
Inhibition of Ribosome Biogenesis by p14(ARF) 65
10.97 MDM2 TP53
29
Sumoylation by RanBP2 regulates transcriptional repression 1
10.63 MDM2 SUMO1
30
TP53 Network 1
Show member pathways
 10.47 MDM2 SUMO1 TP53
Sources

GO Terms for Cheilitis

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Biological processes related to Cheilitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.81 HDAC2 MDM2 MMP9 TP53
2 extracellular matrix organization GO:0030198 9.71 MMP9 SERPINB5 TNF
3 negative regulation of transcription by RNA polymerase II GO:0000122 9.65 HDAC2 MDM2 SUMO1 TNF TP53
4 negative regulation of DNA binding GO:0043392 9.55 HDAC2 SUMO1
5 negative regulation of transcription, DNA-templated GO:0045892 9.55 HDAC2 MDM2 SUMO1 TNF TP53
6 response to antibiotic GO:0046677 9.52 MDM2 TP53
7 cellular response to gamma radiation GO:0071480 9.49 MDM2 TP53
8 positive regulation of release of cytochrome c from mitochondria GO:0090200 9.48 MMP9 TP53
9 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.46 MSH2 TP53
10 positive regulation of protein complex assembly GO:0031334 9.43 SUMO1 TNF
11 morphogenesis of an epithelium GO:0002009 9.4 KRT6A SERPINB5
12 positive regulation of protein export from nucleus GO:0046827 9.37 MDM2 TP53
13 determination of adult lifespan GO:0008340 9.32 MSH2 TP53
14 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.13 MDM2 MMP9 TNF
15 cellular response to actinomycin D GO:0072717 8.62 MDM2 TP53

Molecular functions related to Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.9 CAST HDAC2 CD1A KRT6A MDM2 MMP9
2 protease binding GO:0002020 9.13 CAST TNF TP53
3 enzyme binding GO:0019899 9.02 HDAC2 MDM2 MSH2 SUMO1 TP53
4 SUMO transferase activity GO:0019789 8.96 MDM2
Sources

Sources for Cheilitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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