MCID: CHL056
MIFTS: 48

Cheilitis

Categories: Oral diseases, Skin diseases

Aliases & Classifications for Cheilitis

MalaCards integrated aliases for Cheilitis:

Name: Cheilitis 12 29 15

Classifications:



External Ids:

Disease Ontology 12 DOID:1762
NCIt 49 C79545
SNOMED-CT 67 7847004
ICD10 32 K13.0
UMLS 71 C0007971

Summaries for Cheilitis

Disease Ontology : 12 A lip disease characterized by the inflammation of the lips; which may include the perioral skin, the vermilion border and the labial mucosa.

MalaCards based summary : Cheilitis is related to peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads and actinic cheilitis. An important gene associated with Cheilitis is CAST (Calpastatin), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Isotretinoin and Salicylic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and salivary gland, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and hematopoietic system

Wikipedia : 74 Cheilitis is inflammation of the lips. This inflammation may include the perioral skin (the skin around... more...

Related Diseases for Cheilitis

Diseases related to Cheilitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 466)
# Related Disease Score Top Affiliating Genes
1 peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads 34.8 ERAP1 CAST
2 actinic cheilitis 33.1 TP53 MSH2 MDM2 CDKN1A BCL2 APEX1
3 lip cancer 31.0 TP53 MSH2 MDM2 CDKN1A
4 lichen planus 30.8 TP53 TNF CD1A
5 squamous cell carcinoma 30.4 TP53 STAT3 MMP9 FGFR3 CDKN1A
6 anal fistula 30.2 TNF MSH2 MMP9
7 crohn's disease 30.1 TNF STAT3 CD4 CCR6
8 suppressor of tumorigenicity 3 30.0 TP53 CDKN1A BCL2
9 sialadenitis 29.8 TNF CD4 CCR6
10 candidiasis 29.8 TNF STAT3 CSF2 CCR6
11 severe cutaneous adverse reaction 29.6 TNF PDCD1 CD4
12 histiocytosis 29.5 TNF CSF2 CD1A CCR6
13 allergic hypersensitivity disease 29.5 TNF CSF2 CD4 CCR6
14 pyoderma 29.5 TNF MMP9 CCR6
15 anogenital venereal wart 29.4 TP53 CD4 CCR6
16 lymphangioma 29.3 TP53 STAT3 MSH2 CCR6
17 skin carcinoma 29.2 TP53 MSH2 CSF2 CD274 CCR6
18 salivary gland disease 29.1 TP53 TNF CD4 CCR6
19 common cold 29.0 TNF CSF2 CD4 CCR6
20 intestinal disease 29.0 TP53 TNF CD4 CCR6
21 basal cell carcinoma 29.0 TP53 TNF STAT3 MMP9 CDKN1A CD274
22 leprosy 3 28.9 TNF CSF2 CD4 CD1A CCR6
23 mycobacterium tuberculosis 1 28.9 TNF CD4 CD1A CCR6
24 acute promyelocytic leukemia 28.9 TP53 TNF STAT3 CSF2 CDKN1A BCL2
25 vitiligo-associated multiple autoimmune disease susceptibility 1 28.8 PDCD1 CD4 CD274 CCR6
26 syphilis 28.7 TNF CD4 CCR6 BCL2
27 exanthem 28.5 TNF PDCD1 CSF2 CD4 CD274 CCR6
28 skin disease 28.5 TP53 TNF KRT6A FGFR3 CD4 CD1A
29 inflammatory bowel disease 28.5 TP53 TNF STAT3 MMP9 ERAP1 CSF2
30 autoimmune disease 27.9 TNF STAT3 PDCD1 MMP9 CSF2 CD274
31 systemic lupus erythematosus 27.1 TP53 TNF STAT3 PDCD1 MMP9 CSF2
32 lymphoma, non-hodgkin, familial 26.6 TP53 TNF STAT3 MSH2 MDM2 MALT1
33 myeloma, multiple 25.4 TP53 TNF STAT3 MMP9 MDM2 FGFR3
34 angular cheilitis 12.7
35 cheilitis glandularis 12.7
36 melkersson-rosenthal syndrome 12.2
37 orofacial granulomatosis 11.7
38 actinic prurigo 11.5
39 glucagonoma 11.5
40 ectodermal dysplasia/skin fragility syndrome 11.3
41 ifap syndrome with or without bresheck syndrome 11.2
42 immunodeficiency 12 11.2
43 plummer vinson syndrome 11.2
44 keratosis 10.6
45 ring chromosome 7 10.6 TP53 MDM2
46 actinic keratosis 10.5
47 esophagus verrucous carcinoma 10.5 TP53 MDM2
48 facial paralysis 10.5
49 contact dermatitis 10.4
50 juvenile ankylosing spondylitis 10.4 TNF ERAP1

Graphical network of the top 20 diseases related to Cheilitis:



Diseases related to Cheilitis

Symptoms & Phenotypes for Cheilitis

GenomeRNAi Phenotypes related to Cheilitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.92 CSF2 MSH2 PDCD1 TNF

MGI Mouse Phenotypes related to Cheilitis:

45 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.47 BCL2 CAST CCR6 CD274 CD4 CDKN1A
2 cellular MP:0005384 10.46 APEX1 BCL2 CAST CD274 CD4 CDKN1A
3 immune system MP:0005387 10.46 APEX1 BCL2 CAST CCR6 CD274 CD4
4 homeostasis/metabolism MP:0005376 10.43 APEX1 BCL2 CAST CCR6 CD274 CD4
5 growth/size/body region MP:0005378 10.39 APEX1 BCL2 CAST CD4 CDKN1A CSF2
6 cardiovascular system MP:0005385 10.37 APEX1 BCL2 CAST CCR6 CDKN1A CSF2
7 mortality/aging MP:0010768 10.36 APEX1 BCL2 CAST CD274 CD4 CDKN1A
8 integument MP:0010771 10.31 BCL2 CAST CD274 CD4 CDKN1A CSF2
9 endocrine/exocrine gland MP:0005379 10.3 APEX1 BCL2 CD4 CDKN1A CSF2 ERAP1
10 digestive/alimentary MP:0005381 10.27 BCL2 CD4 CDKN1A FGFR3 MDM2 MMP9
11 nervous system MP:0003631 10.21 BCL2 CAST CCR6 CD4 CDKN1A CSF2
12 craniofacial MP:0005382 10.18 BCL2 CDKN1A CSF2 FGFR3 MDM2 STAT3
13 neoplasm MP:0002006 10.18 APEX1 BCL2 CDKN1A CSF2 FGFR3 MDM2
14 muscle MP:0005369 10.09 APEX1 BCL2 CDKN1A MDM2 MMP9 PDCD1
15 limbs/digits/tail MP:0005371 10.02 CAST CDKN1A FGFR3 MDM2 MMP9 TNF
16 renal/urinary system MP:0005367 9.96 BCL2 CDKN1A CSF2 ERAP1 FGFR3 MDM2
17 no phenotypic analysis MP:0003012 9.92 CD274 CD4 CDKN1A ERAP1 FGFR3 MDM2
18 reproductive system MP:0005389 9.85 APEX1 BCL2 CDKN1A CSF2 FGFR3 MDM2
19 respiratory system MP:0005388 9.56 CDKN1A CSF2 FGFR3 MMP9 PDCD1 STAT3
20 skeleton MP:0005390 9.36 CAST CD274 CDKN1A CSF2 FGFR3 MDM2

Drugs & Therapeutics for Cheilitis

Drugs for Cheilitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isotretinoin Approved Phase 4 4759-48-2 5282379 5538
2
Salicylic acid Approved, Investigational, Vet_approved Phase 4 69-72-7 338
3
Ciclopirox Approved, Investigational Phase 4 29342-05-0 2749
4
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
5
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
6
Aminolevulinic acid Approved Phase 4 106-60-5 137
7 Dermatologic Agents Phase 4
8 Anti-Infective Agents Phase 4
9 Salicylates Phase 4
10 Analgesics, Non-Narcotic Phase 4
11 Cyclooxygenase Inhibitors Phase 4
12 Antifungal Agents Phase 4
13 Anti-Inflammatory Agents Phase 4
14 Analgesics Phase 4
15 Keratolytic Agents Phase 4
16 Antirheumatic Agents Phase 4
17 Anti-Inflammatory Agents, Non-Steroidal Phase 4
18 Methyl 5-aminolevulinate Phase 4
19 Photosensitizing Agents Phase 4
20
Imiquimod Approved, Investigational Phase 2, Phase 3 99011-02-6 57469
21
Chitosan Experimental Phase 2, Phase 3 9012-76-4 71853
22 Adjuvants, Immunologic Phase 2, Phase 3
23 interferons Phase 2, Phase 3
24 Immunologic Factors Phase 2, Phase 3
25 Sunscreening Agents Phase 2, Phase 3
26 Radiation-Protective Agents Phase 2, Phase 3
27 Protective Agents Phase 2, Phase 3
28 Terephthalylidene dicamphor sulfonic acid Phase 2
29 Hemostatics Phase 2
30 Chelating Agents Phase 2
31 Hypolipidemic Agents Phase 2
32 Anticholesteremic Agents Phase 2
33 Lipid Regulating Agents Phase 2
34 Antimetabolites Phase 2
35 Coagulants Phase 2
36
Lidocaine Approved, Vet_approved Phase 1 137-58-6 3676
37
Prilocaine Approved Phase 1 721-50-6 4906
38 Sodium Channel Blockers Phase 1
39 Anesthetics Phase 1
40 Anti-Arrhythmia Agents Phase 1
41 Lidocaine, Prilocaine Drug Combination Phase 1
42 Anesthetics, Local Phase 1
43 Diuretics, Potassium Sparing Phase 1

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Clinical, Laboratorial and Quality of Life Trial to Evaluate the Efficacy and Safety of Low-dose Oral Isotretinoin for Seborrhea. Unknown status NCT01139749 Phase 4 oral isotretinoin;salicylic acid and ciclopirox olamine
2 Randomized Prospective Study Comparing 5% Imiquimod and Photodynamic Therapy for Actinic Cheilitis Completed NCT00849992 Phase 4 Imiquimod 5%
3 Photodynamic Therapy (PDT) With Levulan and Blue Light for the Treatment of Actinic Cheilitis Completed NCT02409732 Phase 4 aminolevulinic acid hydrochloride
4 A Clinical Trial of ALA Photodynamic Therapy for Treatment of Actinic Cheilitis in Patients With Squamous Cell Carcinoma of the Lip. Completed NCT00868088 Phase 4
5 Evaluation of Topical Application of 5% Imiquimod, 0.05% Imiquimod and 0.05% Nanoencapsulated Imiquimod Gel in the Treatment of Actinic Cheilitis: a Randomized Controlled Trial Recruiting NCT04219358 Phase 2, Phase 3 Vehicle Gel Base;Imiquimod 5% gel;Imiquimod 0,05% gel;Imiquimod nanoencapsulated 0,05% gel;Lip sunscreen 30 Sun Protector Factor (SPF);Dexpanthenol
6 Phase II Randomized Controlled Trial to Evaluate the Clinical and Histological Effects of Oral Isotretinoin for the Treatment of Photoaging on Face and Forearms Completed NCT00701740 Phase 2 oral isotretinoin and Mexoryl SX / XL;Mexoryl XL / SX
7 A Randomized Controlled Trial of the Efficacy and Safety of a a Biofunctional Textile in the Management of Atopic Dermatitis Completed NCT01597817 Phase 2
8 Photodynamic Therapy With Metil 5-aminolevulinate for Actinic Cheilitis - A Phase 2 Randomized Double-blind Placebo Controlled Clinical Trial Not yet recruiting NCT03990636 Phase 2 Metil 5-aminolevulinate
9 Phase 1/2 Clinical Trial for the Evaluation of Ingenol Mebutate for Actinic Cheilitis Withdrawn NCT03452566 Phase 1, Phase 2 Ingenol mebutate gel
10 A Randomized, Prospective Study Comparing Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Ablative Fractional Laser Treatment for Actinic Cheilitis Completed NCT02198469 Phase 1 Er:YAG AFL-PDT;MAL-PDT
11 A Randomised Trial Comparing Methyl Aminolaevulinate Photodynamic Therapy With and Without Ablative Fractional Laser Treatment in Patients With Microinvasive Squamous Cell Carcinoma: Results From a 24-month Follow-up Completed NCT02666534 Phase 1 lidocaine-prilocaine 5% cream application;methyl-aminolevulinate application
12 Efficacy of Iontophoresis-assisted Ablative Fractional Laser Photodynamic Therapy With Short Incubation Time for the Treatment of Actinic Keratosis: 12-month Follow-up Results of a Prospective, Randomised, Comparative Trial Completed NCT02670655 Phase 1 lidocaine/prilocaine (5%) application;MAL application
13 Acute Abdomen in Kawasaki Disease: Case Reports Completed NCT03902262
14 Actinic Cheilitis Pre-Treated With DNA Repair Enzyme Cream Withdrawn NCT03224715

Search NIH Clinical Center for Cheilitis

Genetic Tests for Cheilitis

Genetic tests related to Cheilitis:

# Genetic test Affiliating Genes
1 Cheilitis 29

Anatomical Context for Cheilitis

MalaCards organs/tissues related to Cheilitis:

40
Skin, Testes, Salivary Gland, Liver, T Cells, Prostate, Breast

Publications for Cheilitis

Articles related to Cheilitis:

(show top 50) (show all 1573)
# Title Authors PMID Year
1
A case-control study of HLA alleles in Brazilian patients with Melkersson-Rosenthal syndrome. 61
32045706 2020
2
Cheilitis with hemorrhagic crusts of the vermilion lips. 61
32010965 2020
3
Comment on "Cheilitis with hemorrhagic crusts of the vermilion lips". 61
32196632 2020
4
Histopathological features of photodamage and mast cell infiltrate in actinic cheilitis with different grades of epithelial dysplasia. 61
32133685 2020
5
Diagnostic management of cheilitis: an approach based on a recent proposal for cheilitis classification. 61
32566953 2020
6
Coincidence of cheilitis granulomatosa and chronic spontaneous angioedema: successful treatment with dapsone and omalizumab. 61
32447813 2020
7
Squamous cell carcinoma arising from plasma cell cheilitis successfully treated with brachytherapy. 61
32189371 2020
8
Probiotics as a prophylaxis to prevent oral candidiasis in patients with Sjogren's syndrome: a double-blinded, placebo-controlled, randomized trial. 61
32219478 2020
9
Ectodermal dysplasia-skin fragility syndrome: Two new cases and review of this desmosomal genodermatosis. 61
32248567 2020
10
Cardiac MRI of Children with Multisystem Inflammatory Syndrome (MIS-C) Associated with COVID-19: Case Series. 61
32515676 2020
11
Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children. 61
32488505 2020
12
[Lichenoid drug eruption with antituberculosis drugs associated with an anonychia]. 61
32229034 2020
13
Topical tacrolimus with different frequency for exfoliative cheilitis: a pilot study. 61
32431191 2020
14
Discoid lupus erythematosus of the lip: a case of refractory cheilitis. 61
32375573 2020
15
Lip edema in a young female: an unusual cause. 61
32379401 2020
16
Isotretinoin-induced pruritic erythematous lesions and acute chest pain in a 15-year-old girl. 61
31784393 2020
17
Clinical evaluation and efficacy of Imiquimod 3.75% cream for the treatment of actinic keratosis, pigmented basal cell carcinomas, and actinic cheilitis. 61
32239714 2020
18
Vermilionectomy followed by reconstruction of the vermilion mucosa using allograft dermal matrix in patients with actinic cheilitis of the lower lip. 61
32396694 2020
19
A retrospective 11-year study on lip lesions attended at an oral diagnostic service. 61
32040463 2020
20
Successful clearance of extensive/recalcitrant cutaneous warts by acitretin monotherapy: A case series study. 61
32268448 2020
21
A preliminary study on submariners with xerostomia after a 3-month deployment. 61
32332601 2020
22
Siccibacter turicensis from Kangaroo Scats: Possible Implication in Cellulose Digestion. 61
32349400 2020
23
Daylight photodynamic therapy for the management of actinic cheilitis. 61
32266532 2020
24
Novel homozygous deletion of the plakophilin-1 gene in a Chinese patient with ectodermal dysplasia-skin fragility syndrome. 61
32346906 2020
25
PI3K/AKT/mTOR pathway activation in actinic cheilitis and lip squamous cell carcinomas. 61
32255224 2020
26
Atomoxetine-Associated Angular Cheilitis. 61
32235145 2020
27
Oral lesions as first clinical manifestations of Crohn's disease in paediatric patients: a report on 8 cases. 61
32183532 2020
28
Photoallergic contact cheilitis from benzydamine hydrochloride contained in a mouthwash. 61
32232858 2020
29
Therapeutic approaches for actinic cheilitis: therapeutic efficacy and malignant transformation after treatment. 61
32171621 2020
30
Cheilitis caused by contact allergy to toothpaste containing stannous (tin) - two cases. 61
32212164 2020
31
Demographic and Clinicopathologic Features of Actinic Cheilitis and Lip Squamous Cell Carcinoma: a Brazilian Multicentre Study. 61
32077056 2020
32
Ingenol mebutate treatment for actinic cheilitis: clinical, histopathological and p53 profile of 14 cases. 61
32072836 2020
33
[Clinical analysis of denture-related oral mucosal lesions in 185 patients with removable denture]. 61
32524128 2020
34
Cheilitis associated to Penicillium notatum sensitization in a clarinetist. 61
32101170 2020
35
Oral Manifestations in HIV-TB Co- infected Patients and Their Correlation with CD4 Count in Telangana State, India. 61
32181218 2020
36
5-Aminolevulinic acid patch (Alacare) photodynamic therapy for actinic cheilitis: data from a prospective 12-month follow-up study on 21 patients. 61
31999856 2020
37
Interventions for chronic palmoplantar pustulosis. 61
31958161 2020
38
Temporomandibular Disorders and Oral Features in Systemic Lupus Erythematosus Patients: An Observational Study of Symptoms and Signs. 61
32038098 2020
39
Panuveitis revealing Melkersson Rosenthal syndrome: a case report. 61
32395783 2020
40
Chapter 6: Vitamins and Oral Health. 61
31940621 2020
41
Oral potentially malignant disorders: clinical-pathological study of 684 cases diagnosed in a Brazilian population. 61
31880285 2020
42
Actinic cheilitis: Morphometric parameters and its relationship with the degree of epithelial dysplasia. 61
31558280 2020
43
Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis. 61
31880283 2020
44
Expert Recommendations for Prevention, Treatment and Care of Oral Ulcers and Other Mucosal Diseases during the Coronavirus Outbreak. 61
32548599 2020
45
Herpes simplex reactivation after photodynamic therapy for actinic cheilitis in a patient with non-Hodgkin lymphoma: a possible indication for prophylaxis. 61
29512976 2019
46
Proper management of suspicious actinic cheilitis. 61
31032237 2019
47
Effects of Electronic Cigarettes on Oral Cavity: A Systematic Review. 61
31843181 2019
48
Efficacy of vedolizumab in granulomatous cheilitis refractory to TNFα inhibitors. 61
31498875 2019
49
Lip Smacker's Cheilitis. 61
31884455 2019
50
Detection of human papillomaviruses and human polyomaviruses in immunosuppressed and immunocompetent individuals with actinic cheilitis: a case series. 61
31281986 2019

Variations for Cheilitis

Expression for Cheilitis

Search GEO for disease gene expression data for Cheilitis.

Pathways for Cheilitis

Pathways related to Cheilitis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 TP53 TNF STAT3 MDM2 FGFR3 CSF2
2
Show member pathways
13.71 TP53 TNF STAT3 FGFR3 CSF2 CDKN1A
3
Show member pathways
13.45 TP53 PDCD1 MDM2 MALT1 FGFR3 ERAP1
4
Show member pathways
13.4 TP53 TNF STAT3 MDM2 FGFR3 CSF2
5
Show member pathways
13.37 TP53 TNF STAT3 MMP9 FGFR3 CSF2
6
Show member pathways
13.12 TP53 TNF STAT3 PDCD1 MMP9 MDM2
7
Show member pathways
13.1 TP53 TNF MMP9 ERAP1 CDKN1A CD4
8
Show member pathways
13.09 TP53 TNF STAT3 MMP9 CDKN1A BCL2
9
Show member pathways
13.01 TP53 TNF MDM2 FGFR3 CDKN1A BCL2
10
Show member pathways
12.95 TP53 TNF STAT3 MDM2 CSF2 CDKN1A
11
Show member pathways
12.85 TP53 TNF STAT3 MDM2 CDKN1A BCL2
12
Show member pathways
12.84 TP53 STAT3 MSH2 MMP9 MDM2 CSF2
13 12.8 TP53 STAT3 MSH2 MMP9 MDM2 FGFR3
14
Show member pathways
12.76 TP53 MDM2 MALT1 FGFR3 CDKN1A
15
Show member pathways
12.73 TP53 TNF MDM2 CDKN1A BCL2
16
Show member pathways
12.73 TP53 MSH2 MDM2 CDKN1A BCL2 APEX1
17
Show member pathways
12.71 TP53 STAT3 MMP9 MDM2 CDKN1A BCL2
18
Show member pathways
12.65 TP53 STAT3 MDM2 FGFR3 CDKN1A BCL2
19
Show member pathways
12.61 TNF STAT3 PDCD1 MALT1 CSF2 CD4
20 12.59 TNF STAT3 PDCD1 MALT1 CD274 APEX1
21
Show member pathways
12.59 TP53 TNF STAT3 MSH2 CDKN1A CD4
22 12.54 TP53 MSH2 MDM2 CDKN1A APEX1
23
Show member pathways
12.42 TP53 STAT3 MDM2 CDKN1A
24
Show member pathways
12.4 TP53 MDM2 CDKN1A BCL2
25 12.38 TP53 TNF CSF2 CDKN1A CD4
26
Show member pathways
12.36 TNF STAT3 MMP9 CSF2
27 12.36 TP53 STAT3 MMP9 MDM2 FGFR3 CDKN1A
28
Show member pathways
12.34 TP53 STAT3 MDM2 CDKN1A
29 12.33 TP53 STAT3 MDM2 CDKN1A
30 12.33 TP53 TNF STAT3 MMP9 MDM2 CDKN1A
31 12.3 TP53 MMP9 MDM2 CSF2 CDKN1A
32
Show member pathways
12.28 TP53 MDM2 CDKN1A BCL2
33
Show member pathways
12.27 TP53 MDM2 FGFR3 CDKN1A BCL2
34 12.18 TP53 MSH2 MDM2 BCL2
35 12.18 TP53 TNF MDM2 MALT1 CSF2 CAST
36 12.13 TP53 TNF MMP9 BCL2
37 12.1 TP53 MSH2 MDM2 CDKN1A BCL2
38 12.06 TP53 TNF STAT3 MSH2 MMP9 CDKN1A
39 12.05 TP53 TNF MMP9 APEX1
40 12.03 TP53 MDM2 CDKN1A BCL2
41 11.98 TP53 MDM2 CDKN1A BCL2
42 11.95 TNF CSF2 CD4 CD1A
43 11.85 TP53 MDM2 CSF2 CDKN1A
44 11.81 TNF CD4 CCR6
45 11.8 CDKN1A CD4 BCL2
46 11.8 TNF CSF2 CD4 CD1A
47 11.79 STAT3 MMP9 CD4
48 11.74 TP53 MDM2 CDKN1A BCL2 APEX1
49 11.72 TP53 MSH2 MDM2 CDKN1A BCL2
50
Show member pathways
11.69 TNF MMP9 CSF2

GO Terms for Cheilitis

Cellular components related to Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.1 TNF PDCD1 CD4 CD274 CD1A CCR6

Biological processes related to Cheilitis according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 10.07 TP53 MSH2 CDKN1A BCL2 APEX1
2 positive regulation of gene expression GO:0010628 10.07 TP53 TNF STAT3 MDM2 CSF2
3 adaptive immune response GO:0002250 10.04 PDCD1 ERAP1 CD4 CD274 CD1A
4 positive regulation of cell proliferation GO:0008284 9.99 STAT3 MDM2 KRT6A FGFR3 CSF2 BCL2
5 regulation of cell proliferation GO:0042127 9.95 TP53 TNF STAT3 CSF2
6 immune response GO:0006955 9.93 TNF CSF2 CD4 CD274 CD1A CCR6
7 cellular response to lipopolysaccharide GO:0071222 9.91 TNF MALT1 CSF2 CD274
8 regulation of cell cycle GO:0051726 9.86 TP53 STAT3 CDKN1A BCL2
9 cellular response to organic cyclic compound GO:0071407 9.82 TNF STAT3 MDM2
10 response to glucocorticoid GO:0051384 9.81 TNF CDKN1A BCL2
11 positive regulation of protein kinase activity GO:0045860 9.8 TNF CDKN1A CD4
12 response to cytokine GO:0034097 9.79 STAT3 CD274 BCL2
13 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.79 TP53 MDM2 CDKN1A
14 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.77 TNF MMP9 MDM2
15 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.76 TNF MSH2 BCL2
16 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.72 TP53 TNF STAT3
17 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.71 TNF CSF2 BCL2
18 negative regulation of mitotic cell cycle GO:0045930 9.7 TP53 TNF BCL2
19 negative regulation of apoptotic process GO:0043066 9.7 TP53 PDCD1 MMP9 MDM2 MALT1 CDKN1A
20 positive regulation of programmed cell death GO:0043068 9.67 TNF CDKN1A
21 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.67 TP53 TNF
22 regulation of mitochondrial membrane permeability GO:0046902 9.66 STAT3 BCL2
23 response to salt stress GO:0009651 9.66 TP53 TNF
24 cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 9.65 CSF2 CD4
25 response to UV-B GO:0010224 9.65 MSH2 BCL2
26 cellular response to gamma radiation GO:0071480 9.65 TP53 MDM2 CDKN1A
27 cellular response to UV-C GO:0071494 9.62 TP53 MDM2
28 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.62 TNF STAT3 FGFR3 CSF2
29 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.61 TP53 MSH2 CDKN1A
30 T cell lineage commitment GO:0002360 9.6 TP53 BCL2
31 signal transduction by p53 class mediator GO:0072331 9.58 TP53 CDKN1A
32 macrophage differentiation GO:0030225 9.58 MMP9 CSF2 CD4
33 B cell lineage commitment GO:0002326 9.57 TP53 BCL2
34 humoral immune response GO:0006959 9.56 TNF PDCD1 CCR6 BCL2
35 response to X-ray GO:0010165 9.54 TP53 MSH2 CDKN1A
36 cellular response to actinomycin D GO:0072717 9.49 TP53 MDM2
37 response to drug GO:0042493 9.43 TP53 STAT3 MDM2 CDKN1A BCL2 APEX1
38 cytokine-mediated signaling pathway GO:0019221 9.23 TP53 TNF STAT3 MMP9 CSF2 CDKN1A

Molecular functions related to Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.65 TP53 STAT3 MSH2 CDKN1A CD4
2 protein binding GO:0005515 9.62 TP53 TNF STAT3 PDCD1 MSH2 MMP9
3 identical protein binding GO:0042802 9.61 TP53 TNF STAT3 MMP9 MDM2 MALT1
4 protease binding GO:0002020 9.46 TP53 TNF MALT1 BCL2

Sources for Cheilitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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