MCID: CHL075
MIFTS: 25

Cheilitis Glandularis

Categories: Endocrine diseases, Rare diseases, Skin diseases

Aliases & Classifications for Cheilitis Glandularis

MalaCards integrated aliases for Cheilitis Glandularis:

Name: Cheilitis Glandularis 56 74 52 58 71

Characteristics:

Orphanet epidemiological data:

58
cheilitis glandularis
Inheritance: Not applicable; Age of onset: Adult; Age of death: normal life expectancy;

OMIM:

56
Inheritance:
autosomal dominant


HPO:

31
cheilitis glandularis:
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

OMIM 56 118330
MESH via Orphanet 44 C535921
ICD10 via Orphanet 33 K13.0
UMLS via Orphanet 72 C0267034
Orphanet 58 ORPHA1221
MedGen 41 C0267034
UMLS 71 C0267034

Summaries for Cheilitis Glandularis

NIH Rare Diseases : 52 Cheilitis glandularis is a rare inflammatory disorder of the lip. It is mainly characterized by swelling of the lip with hyperplasia of the salivary glands ; secretion of a clear, thick mucus; and variable inflammation. Enlargement and chronic exposure of the mucous membrane on the lower lip becomes affected by the environment, leading to erosion, ulceration, crusting, and, occasionally, infection. Cheilitis glandularis is more common in adult males, although cases have been described in women and children. In Caucasians, it is associated with a relatively high incidence of squamous cell carcinoma of the lip . Although there may be a genetic susceptibility , no definitive cause has been established. Treatment may include surgical excision by vermilionectomy (sometimes called a lip shave), but treatment varies for each individual.

MalaCards based summary : Cheilitis Glandularis is related to cheilitis and sialadenitis. Affiliated tissues include skin, salivary gland and testes, and related phenotypes are thick lower lip vermilion and abnormality of immune system physiology

Wikipedia : 74 Cheilitis is inflammation of the lips. This inflammation may include the perioral skin (the skin around... more...

More information from OMIM: 118330

Related Diseases for Cheilitis Glandularis

Diseases related to Cheilitis Glandularis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 cheilitis 11.1
2 sialadenitis 10.5
3 actinic cheilitis 10.4
4 keratosis 10.3
5 squamous cell carcinoma 10.3
6 lichen planus 10.3
7 hypertriglyceridemia, familial 10.2
8 sarcoidosis 1 10.2
9 hepatitis c 10.2
10 oral lichen planus 10.2
11 47,xyy 10.2
12 actinic keratosis 10.2
13 cystadenoma 10.2
14 factitious disorder 10.2
15 ectropion 10.2
16 angioedema 10.2
17 urticaria 10.2
18 salivary gland disease 10.2

Graphical network of the top 20 diseases related to Cheilitis Glandularis:



Diseases related to Cheilitis Glandularis

Symptoms & Phenotypes for Cheilitis Glandularis

Human phenotypes related to Cheilitis Glandularis:

58 31 (show all 10)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 thick lower lip vermilion 58 31 hallmark (90%) Very frequent (99-80%) HP:0000179
2 abnormality of immune system physiology 58 31 hallmark (90%) Very frequent (99-80%) HP:0010978
3 squamous cell carcinoma 58 31 hallmark (90%) Very frequent (99-80%) HP:0002860
4 abnormal salivary gland morphology 31 hallmark (90%) HP:0010286
5 neoplasm 58 Very frequent (99-80%)
6 everted lower lip vermilion 31 HP:0000232
7 cheilitis 31 HP:0100825
8 abnormality of the salivary glands 58 Very frequent (99-80%)
9 dilatation 31 HP:0002617
10 carcinoma 31 HP:0030731

Symptoms via clinical synopsis from OMIM:

56
Mouth:
enlarged everted lower lip
labial mucous gland hypertrophy
dilatation of excretory ducts
variable inflammation

Oncology:
increased lower lip squamous cell carcinoma

Clinical features from OMIM:

118330

Drugs & Therapeutics for Cheilitis Glandularis

Search Clinical Trials , NIH Clinical Center for Cheilitis Glandularis

Genetic Tests for Cheilitis Glandularis

Anatomical Context for Cheilitis Glandularis

MalaCards organs/tissues related to Cheilitis Glandularis:

40
Skin, Salivary Gland, Testes

Publications for Cheilitis Glandularis

Articles related to Cheilitis Glandularis:

(show top 50) (show all 64)
# Title Authors PMID Year
1
Cheilitis glandularis--a disorder of ductal ectasia. 61 56
3980837 1985
2
Cheilitis glandularis. 61 56
5091868 1971
3
Cheilitis Glandularis of Both Lips: Successful Treatment with a Combination of an Intralesional Steroid Injection and Tacrolimus Ointment. 61
29744227 2018
4
Coexistence of Cheilitis Glandularis and Lichen Planus: Remarkable Response to Anti-inflammatory Treatments. 61
28979035 2017
5
A Diagnostic Approach to Recurrent Orofacial Swelling: A Retrospective Study of 104 Patients. 61
28601424 2017
6
Acute allergic angioedema of upper lip. 61
27217646 2016
7
In vivo confocal microscopy for the oral cavity: Current state of the field and future potential. 61
26786962 2016
8
Cheilitis glandularis: Case report with respect to immunohistochemical findings. 61
26816670 2016
9
Cheilitis glandularis. 61
25994890 2015
10
In vivo reflectance confocal microscopy evaluation of cheilitis glandularis: a report of 5 cases. 61
25238451 2015
11
Cheilitis glandularis simplex. 61
24953596 2014
12
Cheilitis glandularis: immunohistochemical expression of protein water channels (aquaporins) in minor labial salivary glands. 61
23294169 2014
13
Cheilitis glandularis: clinico-histopathological diagnostic criteria. 61
21029266 2011
14
Cheilitis glandularis: two case reports of asian-Japanese men and literature review of Japanese cases. 61
21991474 2011
15
Cheilitis glandularis: a clinicopathological study in 22 patients. 61
20005008 2010
16
Cheilitis glandularis and actinic cheilitis: differential diagnoses - report of three unusual cases. 61
19281710 2009
17
Novel treatment for cheilitis glandularis. 61
19197557 2009
18
Recurrent lower lip swelling in a 62-year-old African American female. Cheilitis glandularis. 61
19022139 2008
19
Cheilitis glandularis progressing to squamous cell carcinoma in an hiv-infected patient: case report. 61
18402312 2007
20
Cheilitis glandularis in albinos: a report of two cases and review of histopathological findings after therapeutic vermilionectomy. 61
17894725 2007
21
A case of cheilitis glandularis superimposed on oral lichen planus: successful palliative treatment with topical tacrolimus and pimecrolimus. 61
17659026 2007
22
Cheilitis glandularis: a clinical marker for both malignancy and/or severe inflammatory disease of the oral cavity. 61
16443070 2006
23
Cheilitis glandularis in an African-American woman: response to antibiotic therapy. 61
16276162 2005
24
Multiple suppurative cystic lesions of the lips and buccal mucosa: a case of suppurative stomatitis glandularis. 61
15660088 2005
25
Spectrum of oral manifestations of HIV/AIDS in the Perm region (Russia) and identification of self-induced ulceronecrotic lingual lesions. 61
15122122 2004
26
Cheilitis glandularis: a case report. 61
15040488 2004
27
Cheilitis glandularis: an unusual histopathologic presentation. 61
12627102 2003
28
Cheilitis glandularis: a rare entity. 61
12588396 2003
29
Cheilitis glandularis: An unusual presentation in a patient with HIV infection. 61
12582351 2003
30
[Glandular cheilitis. 2 case reports]. 61
12242936 2002
31
Testing your diagnostic skills (#53). Case 1: Cheilitis glandularis apostematosa. Actinic keratosis (cheilitis). 61
11545062 2001
32
[Lip, cheilitis glandularis]. 61
11528640 2001
33
Diseases of the lips. 61
9421227 1997
34
Suppurative stomatitis glandularis. 61
7970592 1994
35
A clinico-pathologic presentation: Cheilitis glandularis. 61
8040642 1993
36
Cheilitis glandularis. 61
9791264 1992
37
Cheilitis glandularis: report of a case affecting the upper lip. 61
2641193 1989
38
Persistent sialadenitis of the minor glands--stomatitis glandularis. 61
2742807 1989
39
Cheilitis glandularis: a pediatric case report. 61
2921430 1989
40
Concurrent anomalies: cheilitis glandularis and double lip. Report of a case. 61
3174076 1988
41
Cheilitis glandularis: a case affecting the upper lip. 61
3467290 1986
42
Munchausen's syndrome: a new variety of bleeding type-self-inflicted cheilorrhagia and cheilitis glandularis. 61
3872234 1985
43
Cheilitis glandularis. 61
6592302 1984
44
Cheilitis glandularis: a re-evaluation. 61
6725658 1984
45
[Cheilitis glandularis simplex]. 61
6580190 1983
46
[Cheilitis glandularis simplex]. 61
6862889 1983
47
Factitious cheilitis. 61
6833537 1983
48
Cheilitis glandularis. 61
6954441 1982
49
Factitious lip crusting. 61
6972736 1981
50
Cheilitis glandularis. 61
6930075 1980

Variations for Cheilitis Glandularis

Expression for Cheilitis Glandularis

Search GEO for disease gene expression data for Cheilitis Glandularis.

Pathways for Cheilitis Glandularis

GO Terms for Cheilitis Glandularis

Sources for Cheilitis Glandularis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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