MCID: CHM005
MIFTS: 30

Chemical Colitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Chemical Colitis

MalaCards integrated aliases for Chemical Colitis:

Name: Chemical Colitis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060186
ICD9CM 34 558 558.9
ICD10 32 K52
UMLS 71 C0029512

Summaries for Chemical Colitis

Disease Ontology : 12 A colitis caused by introduction of various chemicals.

MalaCards based summary : Chemical Colitis is related to colitis and inflammatory bowel disease. An important gene associated with Chemical Colitis is VIP (Vasoactive Intestinal Peptide), and among its related pathways/superpathways are Th17 cell differentiation and Th1 Differentiation Pathway. Affiliated tissues include colon, t cells and brain, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Wikipedia : 74 Chemical colitis is a type of colitis, an inflammation of the large intestine or colon, caused by the... more...

Related Diseases for Chemical Colitis

Diseases related to Chemical Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
# Related Disease Score Top Affiliating Genes
1 colitis 30.1 TNF NOD2 IL17A IL10
2 inflammatory bowel disease 28.4 VIP TNF NOD2 IL37 IL17A IL10
3 neurosyphilis 10.4 IL17A IL10
4 ocular toxoplasmosis 10.4 NOD2 IL17A
5 metal allergy 10.4 IL17A IL10
6 cerebral sinovenous thrombosis 10.4 IL17A IL10
7 mycetoma 10.3 IL17A IL10
8 pneumonic plague 10.3 IL17A IL10
9 inflammatory bowel disease 18 10.3 NOD2 IL17A IL10
10 dacryoadenitis 10.2 IL17A IL10
11 hyper ige recurrent infection syndrome 1 10.2 IL17A IL10
12 punctate inner choroidopathy 10.1 TNF IL10
13 tropical endomyocardial fibrosis 10.1 TNF IL10
14 endomyocardial fibrosis 10.1 TNF IL10
15 multifocal choroiditis 10.0 TNF IL10
16 choroiditis 10.0 TNF IL10
17 spotted fever rickettsiosis 10.0 TNF IL10
18 combined thymoma 10.0 TNF IL10
19 gastrointestinal tuberculosis 10.0 TNF NOD2
20 intestinal tuberculosis 10.0 TNF NOD2
21 gastroduodenal crohn's disease 10.0 TNF NOD2
22 post-transplant lymphoproliferative disease 10.0 TNF IL10
23 transient hypogammaglobulinemia 10.0 TNF IL10
24 ischemic colitis 10.0
25 eales disease 10.0 TNF IL10
26 spondylarthropathy 10.0 TNF NOD2
27 granulomatous dermatitis 9.9 TNF NOD2
28 abdominal tuberculosis 9.9 TNF NOD2
29 tenosynovitis 9.9 TNF NOD2
30 pustulosis of palm and sole 9.9 TNF IL17A
31 sporotrichosis 9.9 TNF IL10
32 pneumonic tularemia 9.9 TNF IL17A
33 blastomycosis 9.9 TNF IL17A
34 chlamydia pneumonia 9.9 TNF IL10
35 scleral disease 9.9 TNF IL17A
36 ileocolitis 9.9 TNF NOD2
37 orofacial granulomatosis 9.9 TNF NOD2 IL10
38 peritonitis 9.9
39 acute graft versus host disease 9.9 TNF NOD2 IL10
40 palladium allergic contact dermatitis 9.9 TNF IL17A IL10
41 clonorchiasis 9.9 TNF IL10
42 allergic contact dermatitis 9.9 TNF IL17A IL10
43 contact dermatitis 9.9 TNF IL17A IL10
44 iritis 9.9 TNF NOD2
45 perinatal necrotizing enterocolitis 9.9 TNF NOD2 IL10
46 transverse myelitis 9.9 TNF IL17A IL10
47 myelitis 9.9 TNF IL17A IL10
48 chorioretinitis 9.9 TNF IL17A IL10
49 fungal meningitis 9.9 TNF IL17A IL10
50 meningitis 9.9 TNF IL17A IL10

Graphical network of the top 20 diseases related to Chemical Colitis:



Diseases related to Chemical Colitis

Symptoms & Phenotypes for Chemical Colitis

MGI Mouse Phenotypes related to Chemical Colitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 IL10 IL17A LGR5 NLRP6 NOD2 REG3G
2 homeostasis/metabolism MP:0005376 9.4 BVES CLDN7 IL10 IL17A LGR5 NLRP6

Drugs & Therapeutics for Chemical Colitis

Search Clinical Trials , NIH Clinical Center for Chemical Colitis

Genetic Tests for Chemical Colitis

Anatomical Context for Chemical Colitis

MalaCards organs/tissues related to Chemical Colitis:

40
Colon, T Cells, Brain, Small Intestine, Endothelial, Eye, Bone

Publications for Chemical Colitis

Articles related to Chemical Colitis:

(show top 50) (show all 53)
# Title Authors PMID Year
1
Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer Via Downregulation of Nuclear p65 and HIF-1α. 61
31906321 2020
2
Chemical colitis caused by hydrogen peroxide vaginal douche: A case report. 61
31558970 2019
3
The recruitment of extra-intestinal cells to the injured mucosa promotes healing in radiation enteritis and chemical colitis in a mouse parabiosis model. 61
30617302 2019
4
Successful Conservative Treatment of an Elderly Patient with Corrosive Proctocolitis. 61
31886009 2019
5
Fluid supplementation accelerates epithelial repair during chemical colitis. 61
31002683 2019
6
Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration. 61
30100168 2018
7
Expression and characterization of αvβ5 integrin on intestinal macrophages. 61
29676784 2018
8
Induction of Nitric-Oxide Metabolism in Enterocytes Alleviates Colitis and Inflammation-Associated Colon Cancer. 61
29768197 2018
9
Exercise training-induced modification of the gut microbiota persists after microbiota colonization and attenuates the response to chemically-induced colitis in gnotobiotic mice. 61
28862530 2018
10
The Dynamics of Interleukin-10-Afforded Protection during Dextran Sulfate Sodium-Induced Colitis. 61
29545807 2018
11
Hookworm Secreted Extracellular Vesicles Interact With Host Cells and Prevent Inducible Colitis in Mice. 61
29760697 2018
12
Mast Cells Exert Anti-Inflammatory Effects in an IL10-/- Model of Spontaneous Colitis. 61
29849494 2018
13
Chemical colitis caused by hydrogen peroxide enema in a child: case report and literature review. 61
29631344 2018
14
Chemical colitis caused by hydrogen peroxide enema in a child: case report and literature review. 61
28111419 2016
15
Id1 expression in endothelial cells of the colon is required for normal response to injury. 61
26348574 2015
16
Validation of a modified model of TNBS-induced colitis in rats. How to induce a chemical colitis in rats. 61
25948034 2015
17
Transcriptional corepressor MTG16 regulates small intestinal crypt proliferation and crypt regeneration after radiation-induced injury. 61
25573176 2015
18
In vivo imaging of reactive oxygen and nitrogen species in murine colitis. 61
24983980 2014
19
Interleukin-37. 61
24275599 2013
20
Dynamic changes of peritoneal macrophages and subpopulations during ulcerative colitis to metastasis of colorectal carcinoma in a mouse model. 61
23625042 2013
21
Enhanced excitability of guinea pig ileum myenteric AH neurons during and following recovery from chemical colitis. 61
23628671 2013
22
[Chemical colitis due to hydrogen peroxide enema]. 61
23566413 2013
23
Enhanced excitability of guinea pig inferior mesenteric ganglion neurons during and following recovery from chemical colitis. 61
22961805 2012
24
Colonic mucosal pseudolipomatosis: disinfectant colitis? 61
22647801 2012
25
Severe chemical colitis due to hydrogen peroxide enema. 61
21857533 2012
26
Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis. 61
22815676 2012
27
[A case of chemical colitis caused by hydrogen peroxide enema]. 61
21873825 2011
28
The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. 61
21988661 2011
29
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. 61
21565393 2011
30
A chemical enterocolitis model in zebrafish larvae that is dependent on microbiota and responsive to pharmacological agents. 61
21181946 2011
31
Chemical colitis from a hydrogen peroxide enema. 61
21365964 2010
32
Glutaraldehyde-induced chemical colitis versus ischemic colitis. 61
20155321 2010
33
Chemical colitis caused by peracetic acid or hydrogen peroxide: a challenging dilemma. 61
20066605 2010
34
Chemical colitis due to glutaraldehyde: case series and review of the literature. 61
19104938 2009
35
Chemical colitis induced by peracetic acid: further evidence. 61
19340747 2009
36
Chemical colitis. 61
18209577 2008
37
Urocortin 2 expression in the rat gastrointestinal tract under basal conditions and in chemical colitis. 61
17586086 2007
38
Immunomodulatory effects of ciprofloxacin in TNBS-induced colitis in mice. 61
17253612 2007
39
[A case of idiopathic colitis developed after barium enema]. 61
16498283 2006
40
Inhibitory effect of experimental colitis on fluid absorption in rat jejunum: role of the enteric nervous system, VIP, and nitric oxide. 61
16123200 2006
41
Acute chemical colitis resulting from oral intake of henna. 61
16208120 2005
42
Favorable response to subcutaneous administration of infliximab in rats with experimental colitis. 61
16425394 2005
43
Caustic burns of rectum and colon in emergencies. 61
15191876 2004
44
Effect of DA-6034, a derivative of flavonoid, on experimental animal models of inflammatory bowel disease. 61
10489873 1999
45
Antiinflammatory effects of human milk on chemically induced colitis in rats. 61
9357937 1997
46
[Chemical colitis caused by glutaraldehyde]. 61
9113148 1997
47
Experimental colitis in rats induces low-grade endotoxinemia without hepatobiliary abnormalities. 61
8200252 1994
48
Changes of colonic vasoactive intestinal peptide and cholinergic activity in rats with chemical colitis. 61
1425074 1992
49
The effect of essential fatty acid deficiency on eicosanoid production in the inflamed rat colonic mucosa. 61
2177899 1990
50
Mucosal plaques seen at colonoscopy: chemical colitis or mucosal pseudolipomatosis? 61
2714588 1989

Variations for Chemical Colitis

Expression for Chemical Colitis

Search GEO for disease gene expression data for Chemical Colitis.

Pathways for Chemical Colitis

Pathways related to Chemical Colitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.1 TNF NOD2 IL17A IL10
2
Show member pathways
11.61 TNF IL17A IL10
3 11.39 TNF IL17A IL10
4 11.03 TNF IL17A IL10
5 10.65 TNF IL17A IL10

GO Terms for Chemical Colitis

Biological processes related to Chemical Colitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.76 TNF IL37 IL17A IL10
2 positive regulation of JNK cascade GO:0046330 9.61 TNF NOD2 IL37
3 regulation of inflammatory response GO:0050727 9.58 TNF NOD2 NLRP6
4 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.51 NOD2 IL17A
5 positive regulation of interleukin-6 production GO:0032755 9.5 TNF NOD2 IL37
6 cellular response to hepatocyte growth factor stimulus GO:0035729 9.49 VIL1 IL10
7 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.48 TNF IL10
8 cellular response to lipopolysaccharide GO:0071222 9.46 TNF NOD2 IL37 IL10
9 endothelial cell apoptotic process GO:0072577 9.37 TNF IL10
10 negative regulation of cytokine secretion involved in immune response GO:0002740 9.26 TNF IL10
11 inflammatory response GO:0006954 9.1 TNF REG3G NLRP6 IL37 IL17A IL10
12 receptor biosynthetic process GO:0032800 8.96 TNF IL10

Molecular functions related to Chemical Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidoglycan binding GO:0042834 8.96 REG3G NOD2
2 cytokine activity GO:0005125 8.92 TNF IL37 IL17A IL10

Sources for Chemical Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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