MCID: CHM005
MIFTS: 35

Chemical Colitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Chemical Colitis

MalaCards integrated aliases for Chemical Colitis:

Name: Chemical Colitis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060186
ICD9CM 34 558
ICD10 32 K52
UMLS 71 C0029512

Summaries for Chemical Colitis

Disease Ontology : 12 A colitis caused by introduction of various chemicals.

MalaCards based summary : Chemical Colitis is related to colitis and peritonitis. An important gene associated with Chemical Colitis is VIP (Vasoactive Intestinal Peptide), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. Affiliated tissues include colon, brain and small intestine, and related phenotypes are homeostasis/metabolism and digestive/alimentary

Wikipedia : 74 Chemical colitis is a type of colitis, an inflammation of the large intestine or colon, caused by the... more...

Related Diseases for Chemical Colitis

Diseases related to Chemical Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 463)
# Related Disease Score Top Affiliating Genes
1 colitis 29.6 TNF NOD2 IL6 IL1B IL17A IL10
2 peritonitis 29.2 TNF IL6 IL1B IL17A IL10
3 intestinal disease 28.6 TNF NOD2 IL6 IL1B IL17A IL10
4 inflammatory bowel disease 27.6 VIP TNF NOD2 IL6 IL37 IL1B
5 punctate inner choroidopathy 10.4 TNF IL10
6 physiological polycythemia 10.4 TNF IL1B
7 tropical endomyocardial fibrosis 10.4 TNF IL10
8 neurosyphilis 10.4 IL17A IL10
9 multifocal choroiditis 10.4 TNF IL10
10 systemic onset juvenile idiopathic arthritis 10.4 TNF IL1B
11 staphylococcal toxic shock syndrome 10.3 TNF IL1B
12 spotted fever rickettsiosis 10.3 TNF IL10
13 vulvar vestibulitis syndrome 10.3 TNF IL1B
14 kashin-beck disease 10.3 TNF IL1B
15 ocular toxoplasmosis 10.3 NOD2 IL17A
16 cerebral sinovenous thrombosis 10.3 IL17A IL10
17 inflammatory bowel disease 25 10.3 TNF IL17A
18 congenital cytomegalovirus 10.3 TNF IL1B
19 acute transverse myelitis 10.3 IL6 IL10
20 cinca syndrome 10.3 NOD2 NLRP6 IL1B
21 jejunoileitis 10.2 TNF IL1B
22 prosthetic joint infection 10.2 IL6 IL1B
23 periodontitis, chronic 10.2 IL6 IL1B
24 actinic prurigo 10.2 TNF IL1B
25 uremic pruritus 10.2 IL6 IL1B
26 indolent myeloma 10.2 IL6 IL1B
27 external pathological resorption 10.2 TNF IL6
28 gastroduodenal crohn's disease 10.2 TNF NOD2
29 autoimmune polyendocrine syndrome 10.2 IL1B IL17A IL10
30 scorpion envenomation 10.2 TNF IL6
31 eye lymphoma 10.2 IL6 IL10
32 acute myocarditis 10.2 TNF IL1B IL10
33 gastrointestinal tuberculosis 10.2 TNF NOD2
34 orofacial granulomatosis 10.2 TNF NOD2 IL10
35 tularemia 10.2 TNF IL1B IL17A
36 intestinal tuberculosis 10.2 TNF NOD2
37 glomeruloid hemangioma 10.2 IL6 IL1B
38 systemic autoimmune disease 10.2 IL6 IL17A
39 photokeratitis 10.2 IL6 IL1B
40 mycetoma 10.2 IL17A IL10
41 acute graft versus host disease 10.2 TNF NOD2 IL10
42 aseptic meningitis 10.2 TNF IL1B IL10
43 extrapulmonary tuberculosis 10.2 TNF IL1B IL10
44 transient hypogammaglobulinemia 10.2 TNF IL10
45 pneumonic plague 10.2 TNF IL17A IL10
46 streptococcal toxic-shock syndrome 10.1 TNF IL6
47 choroiditis 10.1 TNF IL17A IL10
48 angioimmunoblastic lymphadenopathy with dysproteinemia 10.1 TNF IL6
49 mevalonic aciduria 10.1 TNF NOD2 IL1B
50 crohn's colitis 10.1 TNF NOD2 IL1B

Graphical network of the top 20 diseases related to Chemical Colitis:



Diseases related to Chemical Colitis

Symptoms & Phenotypes for Chemical Colitis

MGI Mouse Phenotypes related to Chemical Colitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 BVES DCLK1 IL10 IL17A IL1B IL6
2 digestive/alimentary MP:0005381 10.02 DCLK1 IL10 IL17A IL6 LGR5 NLRP6
3 endocrine/exocrine gland MP:0005379 9.97 DCLK1 IL10 IL17A IL6 LGR5 NLRP6
4 immune system MP:0005387 9.85 IL10 IL17A IL1B IL6 NLRP6 NOD2
5 mortality/aging MP:0010768 9.7 DCLK1 IL10 IL17A IL1B IL6 LGR5
6 neoplasm MP:0002006 9.17 DCLK1 IL10 IL1B IL6 LGR5 NLRP6

Drugs & Therapeutics for Chemical Colitis

Search Clinical Trials , NIH Clinical Center for Chemical Colitis

Genetic Tests for Chemical Colitis

Anatomical Context for Chemical Colitis

MalaCards organs/tissues related to Chemical Colitis:

40
Colon, Brain, Small Intestine, Endothelial

Publications for Chemical Colitis

Articles related to Chemical Colitis:

(show top 50) (show all 54)
# Title Authors PMID Year
1
Chemical Colitis Induced by Low-dose Hydrogen Peroxide Enema in a Cocaine User. 61
32211253 2020
2
Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer Via Downregulation of Nuclear p65 and HIF-1α. 61
31906321 2020
3
Chemical colitis caused by hydrogen peroxide vaginal douche: A case report. 61
31558970 2019
4
The recruitment of extra-intestinal cells to the injured mucosa promotes healing in radiation enteritis and chemical colitis in a mouse parabiosis model. 61
30617302 2019
5
Successful Conservative Treatment of an Elderly Patient with Corrosive Proctocolitis. 61
31886009 2019
6
Fluid supplementation accelerates epithelial repair during chemical colitis. 61
31002683 2019
7
Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration. 61
30100168 2018
8
Expression and characterization of αvβ5 integrin on intestinal macrophages. 61
29676784 2018
9
Induction of Nitric-Oxide Metabolism in Enterocytes Alleviates Colitis and Inflammation-Associated Colon Cancer. 61
29768197 2018
10
Exercise training-induced modification of the gut microbiota persists after microbiota colonization and attenuates the response to chemically-induced colitis in gnotobiotic mice. 61
28862530 2018
11
Hookworm Secreted Extracellular Vesicles Interact With Host Cells and Prevent Inducible Colitis in Mice. 61
29760697 2018
12
Mast Cells Exert Anti-Inflammatory Effects in an IL10-/- Model of Spontaneous Colitis. 61
29849494 2018
13
Chemical colitis caused by hydrogen peroxide enema in a child: case report and literature review. 61
29631344 2018
14
The Dynamics of Interleukin-10-Afforded Protection during Dextran Sulfate Sodium-Induced Colitis. 61
29545807 2018
15
Chemical colitis caused by hydrogen peroxide enema in a child: case report and literature review. 61
28111419 2016
16
Id1 expression in endothelial cells of the colon is required for normal response to injury. 61
26348574 2015
17
Validation of a modified model of TNBS-induced colitis in rats. How to induce a chemical colitis in rats. 61
25948034 2015
18
Transcriptional corepressor MTG16 regulates small intestinal crypt proliferation and crypt regeneration after radiation-induced injury. 61
25573176 2015
19
In vivo imaging of reactive oxygen and nitrogen species in murine colitis. 61
24983980 2014
20
Interleukin-37. 61
24275599 2013
21
Dynamic changes of peritoneal macrophages and subpopulations during ulcerative colitis to metastasis of colorectal carcinoma in a mouse model. 61
23625042 2013
22
Enhanced excitability of guinea pig ileum myenteric AH neurons during and following recovery from chemical colitis. 61
23628671 2013
23
[Chemical colitis due to hydrogen peroxide enema]. 61
23566413 2013
24
Enhanced excitability of guinea pig inferior mesenteric ganglion neurons during and following recovery from chemical colitis. 61
22961805 2012
25
Colonic mucosal pseudolipomatosis: disinfectant colitis? 61
22647801 2012
26
Severe chemical colitis due to hydrogen peroxide enema. 61
21857533 2012
27
Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis. 61
22815676 2012
28
The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. 61
21988661 2011
29
[A case of chemical colitis caused by hydrogen peroxide enema]. 61
21873825 2011
30
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. 61
21565393 2011
31
A chemical enterocolitis model in zebrafish larvae that is dependent on microbiota and responsive to pharmacological agents. 61
21181946 2011
32
Chemical colitis from a hydrogen peroxide enema. 61
21365964 2010
33
Glutaraldehyde-induced chemical colitis versus ischemic colitis. 61
20155321 2010
34
Chemical colitis caused by peracetic acid or hydrogen peroxide: a challenging dilemma. 61
20066605 2010
35
Chemical colitis due to glutaraldehyde: case series and review of the literature. 61
19104938 2009
36
Chemical colitis induced by peracetic acid: further evidence. 61
19340747 2009
37
Chemical colitis. 61
18209577 2008
38
Urocortin 2 expression in the rat gastrointestinal tract under basal conditions and in chemical colitis. 61
17586086 2007
39
Immunomodulatory effects of ciprofloxacin in TNBS-induced colitis in mice. 61
17253612 2007
40
[A case of idiopathic colitis developed after barium enema]. 61
16498283 2006
41
Inhibitory effect of experimental colitis on fluid absorption in rat jejunum: role of the enteric nervous system, VIP, and nitric oxide. 61
16123200 2006
42
Acute chemical colitis resulting from oral intake of henna. 61
16208120 2005
43
Favorable response to subcutaneous administration of infliximab in rats with experimental colitis. 61
16425394 2005
44
Caustic burns of rectum and colon in emergencies. 61
15191876 2004
45
Effect of DA-6034, a derivative of flavonoid, on experimental animal models of inflammatory bowel disease. 61
10489873 1999
46
Antiinflammatory effects of human milk on chemically induced colitis in rats. 61
9357937 1997
47
[Chemical colitis caused by glutaraldehyde]. 61
9113148 1997
48
Experimental colitis in rats induces low-grade endotoxinemia without hepatobiliary abnormalities. 61
8200252 1994
49
Changes of colonic vasoactive intestinal peptide and cholinergic activity in rats with chemical colitis. 61
1425074 1992
50
The effect of essential fatty acid deficiency on eicosanoid production in the inflamed rat colonic mucosa. 61
2177899 1990

Variations for Chemical Colitis

Expression for Chemical Colitis

Search GEO for disease gene expression data for Chemical Colitis.

Pathways for Chemical Colitis

Pathways related to Chemical Colitis according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.28 TNF NOD2 IL6 IL37 IL1B IL17A
2
Show member pathways
12.8 TNF IL6 IL1B IL17A IL10
3
Show member pathways
12.67 TNF NOD2 IL6 IL37 IL1B
4
Show member pathways
12.54 TNF IL6 IL1B IL17A IL10
5
Show member pathways
12.52 TNF IL6 IL1B IL17A IL10
6 12.49 TNF IL1B IL17A IL10
7
Show member pathways
12.47 TNF NOD2 IL6 IL1B IL17A IL10
8
Show member pathways
12.28 TNF IL6 IL1B IL17A
9
Show member pathways
12.28 TNF IL6 IL37 IL10
10
Show member pathways
12.21 TNF IL6 IL1B IL17A IL10
11
Show member pathways
12.16 TNF IL6 IL1B IL10
12 12.15 TNF NOD2 NLRP6 IL6 IL1B
13 12.13 TNF NOD2 IL6 IL1B IL10
14 12.12 TNF IL6 IL1B IL10
15 11.96 TNF IL6 IL1B IL10
16 11.94 TNF IL6 IL1B
17 11.92 TNF IL6 IL10
18 11.92 TNF NOD2 IL6 IL1B
19 11.87 TNF IL6 IL1B IL10
20 11.85 TNF IL6 IL1B
21 11.84 TNF IL6 IL1B
22 11.82 TNF IL6 IL1B IL17A
23
Show member pathways
11.8 IL6 IL1B IL17A
24 11.78 TNF IL6 IL1B IL17A IL10
25 11.74 TNF IL1B IL17A IL10
26 11.71 TNF IL6 IL1B IL10
27 11.68 TNF IL6 IL1B IL10
28
Show member pathways
11.63 TNF IL6 IL1B
29 11.63 TNF IL6 IL1B
30
Show member pathways
11.58 TNF IL6 IL1B IL17A IL10
31 11.57 TNF IL6 IL1B
32 11.45 TNF IL6 IL1B
33 11.43 TNF IL6 IL1B IL10
34 11.4 TNF IL6 IL1B IL10
35 11.25 TNF IL6 IL1B
36 11.24 TNF IL6 IL1B IL10
37 11.1 TNF IL6 IL1B IL10
38 10.96 TNF IL6 IL1B IL17A IL10
39 10.89 TNF IL1B
40 10.76 TNF IL6 IL1B IL17A
41 10.75 IL6 IL1B
42 10.39 TNF IL6 IL1B IL10

GO Terms for Chemical Colitis

Cellular components related to Chemical Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 TNF REG3G IL6 IL37 IL1B IL17A
2 extracellular region GO:0005576 9.28 VIP TNF RSPO1 REG3G IL6 IL37

Biological processes related to Chemical Colitis according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.14 TNF NOD2 IL6 IL1B IL17A IL10
2 positive regulation of cell proliferation GO:0008284 10.04 VIP REG3G NOD2 IL6 IL1B
3 immune response GO:0006955 9.95 TNF IL6 IL37 IL1B IL17A IL10
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.89 TNF NOD2 IL37 IL1B
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 TNF NOD2 IL6 IL1B
6 activation of MAPK activity GO:0000187 9.87 TNF NOD2 IL1B
7 defense response to Gram-positive bacterium GO:0050830 9.85 TNF REG3G IL6
8 positive regulation of JNK cascade GO:0046330 9.83 TNF NOD2 IL1B
9 cellular response to organic cyclic compound GO:0071407 9.8 TNF NOD2 IL1B
10 response to glucocorticoid GO:0051384 9.8 TNF IL6 IL10
11 positive regulation of DNA-binding transcription factor activity GO:0051091 9.8 TNF IL6 IL1B IL10
12 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.79 TNF NOD2 IL1B
13 regulation of inflammatory response GO:0050727 9.76 TNF NOD2 NLRP6 IL37
14 positive regulation of interleukin-6 secretion GO:2000778 9.74 TNF IL1B IL17A
15 cytokine-mediated signaling pathway GO:0019221 9.73 TNF IL6 IL37 IL1B IL17A IL10
16 positive regulation of JAK-STAT cascade GO:0046427 9.71 TNF IL6 IL10
17 positive regulation of interleukin-8 production GO:0032757 9.7 TNF NOD2 IL1B
18 inflammatory response GO:0006954 9.7 TNF REG3G NLRP6 IL6 IL37 IL1B
19 negative regulation of lipid catabolic process GO:0050995 9.69 TNF IL1B
20 negative regulation of neurogenesis GO:0050768 9.69 TNF IL6 IL1B
21 astrocyte activation GO:0048143 9.68 TNF IL1B
22 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.68 TNF IL1B
23 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.68 TNF IL1B
24 cellular response to hepatocyte growth factor stimulus GO:0035729 9.68 VIL1 IL10
25 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.67 TNF IL6
26 positive regulation of chemokine biosynthetic process GO:0045080 9.66 TNF IL1B
27 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.66 IL37 IL10
28 negative regulation of lipid storage GO:0010888 9.65 TNF IL6
29 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.65 TNF IL17A
30 regulation of establishment of endothelial barrier GO:1903140 9.64 TNF IL1B
31 endothelial cell apoptotic process GO:0072577 9.63 TNF IL10
32 positive regulation of interleukin-6 production GO:0032755 9.62 TNF NOD2 IL6 IL1B
33 negative regulation of cytokine production involved in immune response GO:0002719 9.61 TNF IL10
34 positive regulation of fever generation GO:0031622 9.61 TNF IL1B
35 positive regulation of glial cell proliferation GO:0060252 9.61 TNF IL6 IL1B
36 negative regulation of cytokine secretion involved in immune response GO:0002740 9.6 TNF IL10
37 sequestering of triglyceride GO:0030730 9.58 TNF IL1B
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 TNF IL1B IL10
39 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.56 TNF IL1B
40 receptor biosynthetic process GO:0032800 9.55 TNF IL10
41 positive regulation of neuroinflammatory response GO:0150078 9.54 TNF IL6 IL1B
42 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.26 TNF NOD2 IL6 IL17A
43 cellular response to lipopolysaccharide GO:0071222 9.1 TNF NOD2 IL6 IL37 IL1B IL10

Molecular functions related to Chemical Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 TNF IL6 IL37 IL1B IL17A IL10
2 interleukin-1 receptor binding GO:0005149 8.96 IL37 IL1B

Sources for Chemical Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....