MCID: CHS005
MIFTS: 30

Chest Wall Lymphoma

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Chest Wall Lymphoma

MalaCards integrated aliases for Chest Wall Lymphoma:

Name: Chest Wall Lymphoma 12 15 74
Malignant Neoplasm of Chest Wall 12
Malignant Tumor of Chest Wall 12
Lymphoma of the Chest Wall 12
Lymphoma of Chest Wall 12
Chest Wall Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6758
NCIt 51 C4580 C6712
SNOMED-CT 69 93754006

Summaries for Chest Wall Lymphoma

Disease Ontology : 12 A thoracic cancer that is located in the chest wall.

MalaCards based summary : Chest Wall Lymphoma, also known as malignant neoplasm of chest wall, is related to diffuse large b-cell lymphoma and burkitt lymphoma. An important gene associated with Chest Wall Lymphoma is SFTPD (Surfactant Protein D), and among its related pathways/superpathways are Cytokine Signaling in Immune system and B cell receptor signaling pathway (KEGG). The drugs Talimogene laherparepvec and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include b cells, breast and bone.

Related Diseases for Chest Wall Lymphoma

Graphical network of the top 20 diseases related to Chest Wall Lymphoma:



Diseases related to Chest Wall Lymphoma

Symptoms & Phenotypes for Chest Wall Lymphoma

Drugs & Therapeutics for Chest Wall Lymphoma

Drugs for Chest Wall Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Talimogene laherparepvec Approved, Experimental, Investigational Phase 2 1187560-31-1
2 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Talimogene Laherparepvec in Treating Patients With Recurrent Breast Cancer That Cannot Be Removed by Surgery Recruiting NCT02658812 Phase 2

Search NIH Clinical Center for Chest Wall Lymphoma

Genetic Tests for Chest Wall Lymphoma

Anatomical Context for Chest Wall Lymphoma

MalaCards organs/tissues related to Chest Wall Lymphoma:

42
B Cells, Breast, Bone

The Foundational Model of Anatomy Ontology organs/tissues related to Chest Wall Lymphoma:

20
The Chest Wall

Publications for Chest Wall Lymphoma

Articles related to Chest Wall Lymphoma:

# Title Authors Year
1
Primary chest wall lymphoma: A rare entity. ( 26458675 )
2015
2
Primary chest wall lymphoma with no history of tuberculous pyothorax: diagnosis and treatment. ( 19114192 )
2008

Variations for Chest Wall Lymphoma

Expression for Chest Wall Lymphoma

Search GEO for disease gene expression data for Chest Wall Lymphoma.

Pathways for Chest Wall Lymphoma

GO Terms for Chest Wall Lymphoma

Cellular components related to Chest Wall Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 rough endoplasmic reticulum GO:0005791 8.62 MYC SFTPD

Biological processes related to Chest Wall Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.54 BCL6 MYC TWIST1
2 negative regulation of apoptotic process GO:0043066 9.5 BCL6 MYC TWIST1
3 regulation of immune response GO:0050776 9.46 BCL6 SFTPD
4 in utero embryonic development GO:0001701 9.43 MYC TWIST1
5 cellular response to hypoxia GO:0071456 9.4 MYC TWIST1
6 negative regulation of cell differentiation GO:0045596 9.26 BCL6 TWIST1
7 positive regulation of epithelial cell proliferation GO:0050679 9.16 MYC TWIST1
8 cytokine-mediated signaling pathway GO:0019221 9.13 BCL6 MYC TWIST1
9 negative regulation of cellular senescence GO:2000773 8.62 BCL6 TWIST1

Molecular functions related to Chest Wall Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.33 BCL6 MYC TWIST1
2 protein dimerization activity GO:0046983 9.26 MYC TWIST1
3 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 8.96 BCL6 MYC
4 E-box binding GO:0070888 8.62 MYC TWIST1

Sources for Chest Wall Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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