CM2
MCID: CHR579
MIFTS: 42

Chiari Malformation Type Ii (CM2)

Categories: Eye diseases, Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Chiari Malformation Type Ii

MalaCards integrated aliases for Chiari Malformation Type Ii:

Name: Chiari Malformation Type Ii 57 53 59 73
Arnold-Chiari Malformation 57 53 29 6
Chiari Malformation Type 2 53 59
Arnold Chiari Malformation Type Ii 53
Arnold-Chiari Malformation Type Ii 59
Arnold-Chiari Malformation Type 2 59
Chiari Type Ii Malformation 53
Arnoldchiari Malformation 76
Cm2 57

Characteristics:

Orphanet epidemiological data:

59
arnold-chiari malformation type ii
Inheritance: Not applicable; Age of onset: Childhood;

OMIM:

57
Inheritance:
multifactorial

Miscellaneous:
symptom onset at birth or infancy arnold-chiari type ii is uniquely associated with myelomeningocele


HPO:

32
chiari malformation type ii:
Inheritance multifactorial inheritance


Classifications:



Summaries for Chiari Malformation Type Ii

NINDS : 54 Chiari malformations (CMs) are structural defects in the base of the skull and the cerebellum, the part of the brain that controls balance. When part of the cerebellum extends through the opening at the base of the skull, the cerebellum and brain stem can be pushed downward. The resulting pressure on the cerebellum can block the flow of cerebrospinal fluid (CSF, the liquid that surrounds and protects the brain and spinal cord) and can cause a range of symptoms including dizziness, muscle weakness, numbness, headache, and problems with hearing, balance, and coordination. Symptoms may change for some individuals depending on buildup of CSF and any resulting pressure on tissue and nerves. CMs are classified by the severity of the disorder and the parts of the brain that protrude into the spinal canal. The most common is Type I, which may not cause symptoms and is often found by accident during an examination for another condition. Type II (also called classic CM and Arnold-Chiari malformation) is usually accompanied by a myelomeningocele--a form of spina bifida that occurs when the spinal canal and backbone do not close before birth, causing the spinal cord to protrude through an opening in the back. This can cause partial or complete paralysis below the spinal opening. Symptoms of Type III--the most serious form of CM--include those seen in Type II, in addition to additional severe neurological defects. In CM Type IV, parts of the creebellum are missing, and portions of the spinal cord may be visible. Other conditions sometimes associated with CM include hydrocephalus, syringomyelia (a fluid-filled cyst in the spinal cord), and spinal curvature.

MalaCards based summary : Chiari Malformation Type Ii, also known as arnold-chiari malformation, is related to craniosynostosis-hydrocephalus-arnold-chiari malformation type i-radioulnar synostosis syndrome and chiari malformation type i, and has symptoms including ataxia, opisthotonus and inspiratory stridor. An important gene associated with Chiari Malformation Type Ii is FUZ (Fuzzy Planar Cell Polarity Protein). The drugs Imiquimod and Aminolevulinic acid have been mentioned in the context of this disorder. Affiliated tissues include cerebellum, brain and spinal cord, and related phenotypes are agenesis of corpus callosum and hydrocephalus

NIH Rare Diseases : 53 Chiari malformation type 2 (CM type II) is a type of Chiari malformation in which both the cerebellum and brain stem tissue extend into the foramen magnum (the hole at the skull base for passing of the spinal cord). CM type II is usually accompanied by a myelomeningocele (a form of spina bifida that occurs when the spinal canal and backbone do not close before birth), which can result in partial or complete paralysis of the area below the spinal opening. While the severity of CM type II can vary greatly, it can potentially cause severe, life-threatening complications during infancy or childhood.  The exact cause of CM type II is not known but it appears to be due to defects in the brain and spinal cord that occur during fetal development. Treatment includes surgery to ease symptoms and/or stop the progression of damage to the nervous system. For most people, surgery improves or stabilizes symptoms. Some people may require more than one surgery.

OMIM : 57 Chiari malformation type II (CM2), also known as the Arnold-Chiari malformation, consists of elongation and descent of the inferior cerebellar vermis, cerebellar hemispheres, pons, medulla, and fourth ventricle through the foramen magnum into the spinal canal. CM2 is uniquely associated with myelomeningocele (open spina bifida; see 182940) and is found only in this population (Stevenson, 2004). It is believed to be a disorder of neuroectodermal origin (Schijman, 2004). For a general phenotypic description of the different forms of Chiari malformations, see Chiari malformation type I (CM1; 118420). (207950)

Wikipedia : 76 A Chiari malformation (CM) is a structural defect in the cerebellum, characterised by a downward... more...

Related Diseases for Chiari Malformation Type Ii

Diseases in the Chiari Malformation family:

Chiari Malformation Type I Chiari Malformation Type Ii
Chiari Malformation Type 3 Chiari Malformation Type 4

Diseases related to Chiari Malformation Type Ii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 craniosynostosis-hydrocephalus-arnold-chiari malformation type i-radioulnar synostosis syndrome 12.5
2 chiari malformation type i 12.5
3 chiari malformation type 3 11.8
4 chiari malformation type 4 11.6
5 corpus callosum, agenesis of 11.5
6 hydrocephalus, congenital, 1 11.4
7 central sleep apnea 11.4
8 congenital laryngeal palsy 11.4
9 craniofacial dyssynostosis 11.4
10 syringomyelia, noncommunicating isolated 11.2
11 respiratory failure 10.6
12 chiari malformation 10.5
13 headache 10.5
14 sleep apnea 10.4
15 arthropathy 10.4
16 congenital hydrocephalus 10.4
17 myelomeningocele 10.3
18 hydrocephalus due to congenital stenosis of aqueduct of sylvius 10.3
19 klippel-feil syndrome 10.3
20 spondylolysis 10.3
21 arachnoid cysts 10.3
22 syncope 10.3
23 hydromyelia 10.3
24 carpal tunnel syndrome 10.1
25 neurofibromatosis, type i 10.1
26 noonan syndrome 1 10.1
27 antley-bixler syndrome without genital anomalies or disordered steroidogenesis 10.1
28 cerebellar hypoplasia 10.1
29 dandy-walker syndrome 10.1
30 spondylocostal dysostosis 1, autosomal recessive 10.1
31 focal dermal hypoplasia 10.1
32 neural tube defects, folate-sensitive 10.1
33 anxiety 10.1
34 major depressive disorder 10.1
35 chromosome 16p13.3 deletion syndrome, proximal 10.1
36 mononeuropathy of the median nerve, mild 10.1
37 osteopetrosis 10.1
38 spinal muscular atrophy 10.1
39 antley-bixler syndrome 10.1
40 fetal alcohol syndrome 10.1
41 alcohol-related birth defect 10.1
42 vitamin b12 deficiency 10.1
43 scoliosis 10.1
44 cardiac arrest 10.1
45 thrombosis 10.1
46 acromesomelic dysplasia 10.1
47 meningococcal meningitis 10.1
48 dementia 10.1
49 porphyria 10.1
50 multiple cranial nerve palsy 10.1

Graphical network of the top 20 diseases related to Chiari Malformation Type Ii:



Diseases related to Chiari Malformation Type Ii

Symptoms & Phenotypes for Chiari Malformation Type Ii

Symptoms via clinical synopsis from OMIM:

57
Neurologic Central Nervous System:
hydrocephalus
ataxia
spasticity
bulbar signs
hypotonia
more
Abdomen Gastrointestinal:
dysphagia
poor feeding
choking

Head And Neck Eyes:
nystagmus

Respiratory:
inspiratory stridor
expiratory apnea with cyanosis


Clinical features from OMIM:

207950

Human phenotypes related to Chiari Malformation Type Ii:

32 (show all 19)
# Description HPO Frequency HPO Source Accession
1 agenesis of corpus callosum 32 frequent (33%) HP:0001274
2 hydrocephalus 32 HP:0000238
3 nystagmus 32 HP:0000639
4 ataxia 32 HP:0001251
5 muscular hypotonia 32 HP:0001252
6 dysphagia 32 HP:0002015
7 feeding difficulties 32 HP:0011968
8 bulbar signs 32 HP:0002483
9 arnold-chiari malformation 32 HP:0002308
10 generalized hypotonia 32 HP:0001290
11 limb muscle weakness 32 HP:0003690
12 heterotopia 32 HP:0002282
13 cyanosis 32 HP:0000961
14 myelomeningocele 32 HP:0002475
15 opisthotonus 32 HP:0002179
16 syringomyelia 32 HP:0003396
17 inspiratory stridor 32 HP:0005348
18 cervical myelopathy 32 HP:0002318
19 occipital neuralgia 32 HP:0012318

UMLS symptoms related to Chiari Malformation Type Ii:


ataxia, opisthotonus, inspiratory stridor, headache, occipital, muscle spasticity

Drugs & Therapeutics for Chiari Malformation Type Ii

Drugs for Chiari Malformation Type Ii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 755)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 99011-02-6 57469
2
Aminolevulinic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 106-60-5 137
3
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
4
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
5
Lorazepam Approved Phase 4 846-49-1 3958
6
Atropine Approved, Vet_approved Phase 4 51-55-8, 5908-99-6 174174
7
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
8
Biperiden Approved, Investigational Phase 4 514-65-8 2381
9
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-61-6, 62-31-7 681
10
Nitric Oxide Approved Phase 4,Phase 2,Not Applicable 10102-43-9 145068
11
Tocopherol Approved, Investigational Phase 4,Not Applicable 1406-66-2 14986
12
Insulin Glargine Approved Phase 4 160337-95-1
13
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-66-6
14
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
15
Dimethyl fumarate Approved, Investigational Phase 4 624-49-7 637568 5271565
16
Adalimumab Approved Phase 4 331731-18-1 16219006
17
Benzoyl peroxide Approved Phase 4,Not Applicable 94-36-0 7187
18
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 64-17-5 702
19
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Not Applicable 51-84-3 187
20
Verteporfin Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 129497-78-5
21
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 94-09-7, 1994-09-7 2337
22 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
23
Sulfadiazine Approved, Investigational, Vet_approved Phase 4,Not Applicable 68-35-9 5215
24
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 124-94-7 31307
25
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 137-58-6 3676
26
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1,Early Phase 1,Not Applicable 22916-47-8 4189
27
Betamethasone Approved, Vet_approved Phase 4,Phase 1,Not Applicable 378-44-9 9782
28
Alendronate Approved Phase 4,Phase 2,Phase 3 66376-36-1, 121268-17-5 2088
29
Methylene blue Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 61-73-4
30
Tetracaine Approved, Vet_approved Phase 4,Phase 3,Phase 2 94-24-6 5411
31
Petrolatum Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 8009-03-8
32
Silicon Approved, Investigational Phase 4,Not Applicable 7440-21-3 4082203
33
Tranexamic Acid Approved Phase 4,Not Applicable 1197-18-8 5526
34
Natamycin Approved Phase 4,Phase 3 7681-93-8 5281099
35
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 9005-49-6 772 46507594
36
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-28-2 5757
37 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 979-32-8
38
Polyestradiol phosphate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 28014-46-2
39
Methoxsalen Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 298-81-7 4114
40
Rivastigmine Approved, Investigational Phase 4,Phase 3,Not Applicable 123441-03-2 77991
41
Adapalene Approved Phase 4,Phase 2 106685-40-9 60164
42
Polihexanide Approved, Investigational Phase 4,Phase 2 28757-47-3
43
Ropivacaine Approved Phase 4,Phase 3,Phase 1,Not Applicable 84057-95-4 175805 71273
44
Etidronic acid Approved Phase 4,Phase 3 7414-83-7, 2809-21-4 3305
45
Teriparatide Approved, Investigational Phase 4,Phase 2 52232-67-4 16133850
46
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
47
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 83-43-2 6741
48
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 50-24-8 5755
49
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 302-25-0
50 Lycopene Approved, Investigational Phase 4 502-65-8 446925

Interventional clinical trials:

(show top 50) (show all 1480)
# Name Status NCT ID Phase Drugs
1 Therapeutic Effects of Monochromatic Infrared Energy Therapy on Patients With Chronic Low Back Pain Unknown status NCT01920971 Phase 4
2 Far Infrared Therapy on Peripheral Artery Disease in Hemodialysis Patients Unknown status NCT01095549 Phase 4
3 Reverse Phototherapy With Super Light-emitting Diode(Super-LED) for Hyperbilirubinemia in Term and Late Preterm Infants Unknown status NCT01340339 Phase 4
4 Use of a New Phototherapy Device (BBloo®) for the Treatment of Hyperbilirubinemia in the Newborn Infant Unknown status NCT02156050 Phase 4
5 Imiquimod 3.75% Cream in Combination With Cryotherapy in the Treatment of Hypertrophic Actinic Keratoses Unknown status NCT01229319 Phase 4 Cryotherapy alone to Left arm plus cryotherapy + imiquimod to Right arm;Cryotherapy alone to Left arm plus cryotherapy + imiquimod to Right arm
6 Long Term Efficacy and Safety of Eryfotona AK-NMSC® in Patients With Actinic Keratosis Unknown status NCT01656226 Phase 4
7 Comparing Different Platelet Rich Plasma (PRP) Treatment Regimens for Management of Androgenic Alopecia Unknown status NCT02999737 Phase 4
8 Maggot Debridement Therapy Versus Conventional Dressing Therapy to Treat Diabetic Foot Ulcers Unknown status NCT02816749 Phase 4
9 Superficial Basal Cell Carcinoma Treatment With Topical Photodynamic Therapy With Fractionated 5-aminolevulinic Acid 20% Versus Two Stage Methylaminolevulinate Unknown status NCT01491711 Phase 4 Methylaminolevulinate PDT in 2 sessions;Fractionated 5-aminolevulinic acid hydrochloride 20% gel PDT
10 Optimization of Procedural Sedation Protocol Used for Dental Care Delivery in People With Mental Disability Unknown status NCT02078336 Phase 4 Midazolam Mylan;Lorazepam Mylan;Valium + Akineton + Dehydrobenzperidol + Atropine sulfate
11 Far Infrared Therapy on AV Fistula Flow, Endothelial Function and Echocardiography in ESRD Patients Unknown status NCT01138254 Phase 4
12 Atorvastatin Versus Vitamin E in Treatment of Non-alcoholic Fatty Liver Disease Unknown status NCT01720719 Phase 4 atorvastatin;Vitamin E
13 Exenatide Compared With Insulin Glargine to Change Liver Fat Content in Type 2 Diabetes Unknown status NCT02303730 Phase 4 Exenatide;insulin glargine
14 The Influence of Adalimumab on Cardiovascular and Metabolic Risk in Psoriasis Unknown status NCT01088165 Phase 4 Adalimumab treatment arm;Fumaric acid esters treatment group
15 A Randomized Trial of Angiotensin Receptor bLocker,Fimasartan, in Aortic Stenosis (ALFA Trial) Unknown status NCT01589380 Phase 4 Fimasartan;Placebo
16 Compliance and Tolerability of Rivastigmine Transdermal Patch 10 cm² in Patients With Probable Alzheimer's Disease. Completed NCT00731224 Phase 4 Rivastigmine transdermal patch
17 The Effects of the Rivastigmine Patch on Parkinson's Disease With Memory and/or Thinking Problems Completed NCT00988117 Phase 4 Rivastigmine Patch 9.5 cm2
18 Open-Label Safety Study to Evaluate Imiquimod Cream, 5% for Large Areas of Actinic Keratosis Completed NCT00116649 Phase 4 imiquimod cream
19 Anti Propionibacterium(P.) Acnes Activity of Epiduo® Gel Compared to Benzoyl Peroxide (BPO) 2.5% Gel Completed NCT01188538 Phase 4 Epiduo gel;BPO
20 Efficacy of Intraoperative Surgical Scrubbing in Reducing Bacterial Load After Nail Removal Surgery Completed NCT01330706 Phase 4 Polihexanide
21 Prevention of Catheter-Associated Infection With the Skin Disinfectant Octenidine Dihydrochloride Completed NCT00515151 Phase 4 0.1% Octenidine with 30% 1-propanol and 45% 2-propanol;74% Ethanol with 10% 2-propanol
22 A 24 Week, Multicenter, Open, Evaluation of the Clinical Effectiveness of the Once-daily 10 cm^2 Rivastigmine Patch Formulation in Patients With Probable Alzheimer's Disease (EXTRA) Completed NCT00622713 Phase 4 Rivastigmine transdermal patch
23 Combined Static and Dynamic Orthotic Treatment of the PIP Joint Completed NCT01914991 Phase 4
24 Effect of Systemic Ropivacaine on Hyperalgesia, Flare Reaction and Peripheral Nerve Excitability Completed NCT00900913 Phase 4 ropivacaine (Naropin)
25 Botulinum Toxin Treatment for Localized Vitiligo Completed NCT01051687 Phase 4 Botulinum toxin A
26 Prevention of Osteoporosis in Breast Cancer Survivors Completed NCT00567606 Phase 4
27 A 12 Week, Multicenter, Open Label Evaluation of Caregiver Preference, Safety and Tolerability of Exelon® Patch (Rivastigmine Transdermal) in Patients With Alzheimer's Disease Completed NCT01047579 Phase 4 Rivastigmine transdermal
28 Prospective Randomized Controlled Treatment Trial for Chronic Central Serous Chorioretinopathy Completed NCT01797861 Phase 4
29 Teriparatide (Forsteo) Treatment in Postmenopausal Women: Mechanism of Action Completed NCT01293292 Phase 4 Teriparatide
30 Nimodipine for Treating Acute Massive Cerebral Infarction Completed NCT02248233 Phase 4 Nimodipine;Saline + citicoline
31 A Clinical Trial to Study the Effects of Two Drugs, Lycopene and Prednisolone in Patients With Oral Lichen Planus Completed NCT02587117 Phase 4 lycopene;Prednisolone
32 STEP: Study of Imaging Techniques (ImaTx and DXA) in Postmenopausal Women With OstEoporosis Using Preotact (FP-008-ES) Completed NCT00583518 Phase 4 Parathyroid hormone (PTH)
33 Effect of Parathyroid Hormone (PTH) and Weight-Bearing on Bone in Spinal Cord Injury (SCI) Completed NCT00826228 Phase 4 teriparatide
34 Efficacy and Safety Study of Fentanyl Transdermal Patch for Treatment of Chronic Pain Completed NCT01902524 Phase 4 Fentanyl-TTS
35 Pain Management in Corneal Collagen Crosslinking for Keratoconus Completed NCT02867176 Phase 4 Gabapentin;Ketorolac
36 Bioequivalence of Ethylenediamine Dihydrochloride Study Completed NCT01798589 Phase 4 Ethylenediamine dihydrochloride
37 Efficiency of a Jellyfish Sting Inhibitor Sun Lotion and Protocols for Jellyfish Sting Pain Relief Completed NCT00693641 Phase 4
38 Comparative Analysis of Cost-effectiveness of Silver Dressing in Burns Completed NCT02108535 Phase 4 Nanocrystalline silver;Silver Sulphadiazine
39 Exelon Patch and Combination With Memantine Comparative Trial Completed NCT01025466 Phase 4 Rivastigmine transdermal patch (Exelon patch), memantine;Rivastigmine transdermal patch
40 Long-term Effects of Imiquimod and Diclofenac in Actinic Keratoses (LEIDA 2) Completed NCT01453179 Phase 4 Imiquimod;Diclofenac
41 Long-term Effects of Imiquimod and Diclofenac in Actinic Keratoses Completed NCT00777127 Phase 4 Imiquimod;Diclofenac
42 The Efficacy of Laser Assisted Hair Removal in the Treatment of Acne Keloidalis Nuchae; a Pilot Study Completed NCT01548898 Phase 4
43 Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus Completed NCT02858297 Phase 4 Glucosamine sulfate;triamcinolone acetonide
44 Imiquimod 5% Cream in the Treatment of External Genital or Perianal Warts in HIV+ Patients Completed NCT00761371 Phase 4 Imiquimod 5% cream
45 Clinical Trial to Evaluate the Efficacy of Smoking Cessation Completed NCT01538394 Phase 4 Varenicline;Nicotine patches;Placebo (nicotine patches)
46 Study to Assess on a Molecular Level the Influence of a 5 % Dexpanthenol Ointment in Subjects With Superficial Injuries Completed NCT00859196 Phase 4 Dexpanthenol (BAY81-2996);Placebo
47 Fractional CO2 Treatment of Acne Scars in Asians Completed NCT00748462 Phase 4
48 Treatment of Lower Extremity Spider Veins With Excel V Completed NCT01362192 Phase 4
49 Radiation Exposure During Endoscopic Retrograde Cholangiopancreatography Between Prone and Left Lateral Decubitus Completed NCT01599351 Phase 4
50 Photodynamic Therapy for Lentigo Maligna Using 5-aminolevulinic Acid Nanoemulsion as a Light Sensitizing Cream Completed NCT02685592 Phase 4 5-aminolevulinic acid nanoemulsion

Search NIH Clinical Center for Chiari Malformation Type Ii

Genetic Tests for Chiari Malformation Type Ii

Genetic tests related to Chiari Malformation Type Ii:

# Genetic test Affiliating Genes
1 Arnold-Chiari Malformation 29

Anatomical Context for Chiari Malformation Type Ii

MalaCards organs/tissues related to Chiari Malformation Type Ii:

41
Cerebellum, Brain, Spinal Cord, Tonsil, Pons, Eye, Pituitary

Publications for Chiari Malformation Type Ii

Articles related to Chiari Malformation Type Ii:

(show top 50) (show all 236)
# Title Authors Year
1
A novel proximal 3q29 chromosome microdeletion in a Chinese patient with Chiari malformation type II and Sprengel's deformity. ( 29410707 )
2018
2
Spinal neuraxial anaesthesia for caesarean section in a parturient with type I Arnold Chiari malformation and syringomyelia. ( 30013789 )
2018
3
Decompression for Chiari malformation type II in individuals with myelomeningocele in the National Spina Bifida Patient Registry. ( 30141752 )
2018
4
Anesthetic management of parturients with Arnold Chiari malformation-I: a multicenter retrospective study. ( 30414718 )
2018
5
Management of parturients in active labor with Arnold Chiari malformation, tonsillar herniation, and syringomyelia. ( 28217389 )
2017
6
Major depressive disorder comorbid severe hydrocephalus caused by Arnold-Chiari malformation. ( 29497204 )
2017
7
Sequential morphological change of Chiari malformation type II following surgical repair of myelomeningocele. ( 26936599 )
2016
8
Contiguous triple spinal dysraphism associated with Chiari malformation Type II and hydrocephalus: an embryological conundrum between the unified theory of Pang and the unified theory of McLone. ( 26474100 )
2015
9
Chronic CSF leak causing syringomyelia and pseudo-Arnold-Chiari malformation. ( 26628487 )
2015
10
Restoration of the efferent phase of the sneeze reflex after regression of an Arnold-Chiari malformation with compression of the medulla oblongata. ( 23354897 )
2013
11
The quality of life and psychiatric morbidity in patients operated for Arnold-Chiari malformation type I. ( 23437799 )
2013
12
Sleep-disordered breathing in children with Chiari malformation type II and myelomeningocele. ( 22564146 )
2012
13
Psychosis risk syndrome comorbid with panic attack disorder in a cannabis-abusing patient affected by Arnold-Chiari malformation type I. ( 22285366 )
2012
14
A case of Arnold-Chiari malformation associated with dementia. ( 22772701 )
2012
15
A successful pregnancy outcome after antenatal surgical decompression of Arnold Chiari malformation. ( 24293859 )
2012
16
Endoscopic resection of odontoid process in Arnold Chiari malformation type II. ( 22026144 )
2011
17
Congenital stridor in the context of Chiari malformation type II: the etiological role of vernix caseosa granulomatous meningitis. ( 21961543 )
2011
18
Obstructive and central sleep apnoea in Arnold-Chiari malformation: resolution following surgical decompression. ( 20835768 )
2011
19
Laugh headaches: a rare form of headache associated with type 1 Arnold-Chiari malformation. ( 21899688 )
2011
20
Transnasal endoscopic removal of malformation of the odontoid process in a patient with type I Arnold-Chiari malformation: a case report. ( 22058600 )
2011
21
Primary cerebellar tuberculoma in Arnold-Chiari malformation mimicking posterior cranial fossa tumor: the first report. ( 24353933 )
2011
22
Dexmedetomidine for an awake fiber-optic intubation of a parturient with Klippel-Feil syndrome, Type I Arnold Chiari malformation and status post released tethered spinal cord presenting for repeat cesarean section. ( 24765318 )
2011
23
Improvement of obstructive sleep apneas caused by hydrocephalus associated with Chiari malformation Type II following surgery. ( 20887105 )
2010
24
Arnold-Chiari malformation. ( 20220728 )
2010
25
Etiopathology of Arnold-Chiari malformation: a fetal rat model of dysraphism. ( 20693807 )
2010
26
Clinical and radiological findings in Arnold Chiari malformation. ( 21702272 )
2010
27
Respiratory depression during VP shunting in Arnold Chiari malformation Type-II, a rare complication (Case reports and review of literature). ( 21887176 )
2009
28
Sleep disorder: a possible cause of attention deficit in children and adolescents with Chiari malformation type II. ( 19330206 )
2009
29
Blood-brain barrier ultrastructural alterations in human congenital hydrocephalus and Arnold-Chiari malformation. ( 19353430 )
2009
30
Postnatal ascent of the cerebellar tonsils in Chiari malformation Type II following surgical repair of myelomeningocele. ( 18759600 )
2008
31
Uneventful epidural labor analgesia and vaginal delivery in a parturient with Arnold-Chiari malformation type I and sickle cell disease. ( 16912855 )
2007
32
Chiari malformation type II with vanishing cerebellum. ( 17079840 )
2006
33
Arnold-Chiari malformation type I in military conscripts: symptoms and effects on service fitness. ( 16578991 )
2006
34
Symptomatic Arnold-Chiari malformation and cranial nerve dysfunction: a case study of applied kinesiology cranial evaluation and treatment. ( 15883570 )
2005
35
Acute respiratory failure and sleep-disordered breathing in Arnold-Chiari malformation. ( 16202827 )
2005
36
Anesthetic management in a child with Arnold-Chiari malformation and bilateral vocal cord paralysis. ( 16324032 )
2005
37
Arnold-Chiari malformation with syrinx presenting as carpal tunnel syndrome: a case report. ( 14970984 )
2004
38
Somatosensory evoked potentials in Arnold-Chiari malformation. ( 15036428 )
2004
39
Congenital-type nystagmus in Arnold-Chiari malformation. ( 12707671 )
2003
40
Arnold-Chiari malformation. ( 12810499 )
2003
41
Spinal anesthesia for cesarean delivery in a woman with a surgically corrected type I Arnold Chiari malformation. ( 12818976 )
2003
42
Arnold-Chiari malformation type I and sleep-disordered breathing: an uncommon manifestation of an important pediatric problem. ( 12847429 )
2003
43
Sudden respiratory arrest and Arnold-Chiari malformation. ( 12865061 )
2003
44
Respiratory failure in Arnold-Chiari malformation. ( 11844969 )
2002
45
Neuropathic shoulder arthropathy associated with syringomyelia and Arnold-Chiari malformation (type I). ( 11908585 )
2002
46
Neurofibromatosis type I and Arnold-Chiari malformation. ( 12046833 )
2002
47
Sagittal profiles of the spine in scoliosis associated with an Arnold-Chiari malformation with or without syringomyelia. ( 12131445 )
2002
48
Periodic alternating nystagmus associated with Arnold-Chiari malformation. ( 11779333 )
2001
49
Arnold-Chiari malformation and pregnancy. ( 15321630 )
2001
50
Arnold Chiari malformation and nystagmus of skew. ( 11248904 )
2001

Variations for Chiari Malformation Type Ii

Expression for Chiari Malformation Type Ii

Search GEO for disease gene expression data for Chiari Malformation Type Ii.

Pathways for Chiari Malformation Type Ii

GO Terms for Chiari Malformation Type Ii

Sources for Chiari Malformation Type Ii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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