MCID: CHR579
MIFTS: 49

Chiari Malformation Type Ii

Categories: Eye diseases, Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Chiari Malformation Type Ii

MalaCards integrated aliases for Chiari Malformation Type Ii:

Name: Chiari Malformation Type Ii 58 54 60 30 74
Arnold-Chiari Malformation 58 77 54 6
Chiari Malformation Type 2 54 60
Arnold Chiari Malformation Type Ii 54
Arnold-Chiari Malformation Type Ii 60
Arnold-Chiari Malformation Type 2 60
Chiari Type Ii Malformation 54
Cm2 58

Characteristics:

Orphanet epidemiological data:

60
arnold-chiari malformation type ii
Inheritance: Not applicable; Age of onset: Childhood;

OMIM:

58
Inheritance:
multifactorial

Miscellaneous:
symptom onset at birth or infancy arnold-chiari type ii is uniquely associated with myelomeningocele


HPO:

33
chiari malformation type ii:
Inheritance multifactorial inheritance


Classifications:



Summaries for Chiari Malformation Type Ii

NINDS : 55 Chiari malformations (CMs) are structural defects in the base of the skull and the cerebellum, the part of the brain that controls balance. When part of the cerebellum extends through the opening at the base of the skull, the cerebellum and brain stem can be pushed downward. The resulting pressure on the cerebellum can block the flow of cerebrospinal fluid (CSF, the liquid that surrounds and protects the brain and spinal cord) and can cause a range of symptoms including dizziness, muscle weakness, numbness, headache, and problems with hearing, balance, and coordination. Symptoms may change for some individuals depending on buildup of CSF and any resulting pressure on tissue and nerves. CMs are classified by the severity of the disorder and the parts of the brain that protrude into the spinal canal. The most common is Type I, which may not cause symptoms and is often found by accident during an examination for another condition. Type II (also called classic CM and Arnold-Chiari malformation) is usually accompanied by a myelomeningocele--a form of spina bifida that occurs when the spinal canal and backbone do not close before birth, causing the spinal cord to protrude through an opening in the back. This can cause partial or complete paralysis below the spinal opening. Symptoms of Type III--the most serious form of CM--include those seen in Type II, in addition to additional severe neurological defects. In CM Type IV, parts of the cerebellum are missing, and portions of the spinal cord may be visible. Other conditions sometimes associated with CM include hydrocephalus, syringomyelia (a fluid-filled cyst in the spinal cord), and spinal curvature.

MalaCards based summary : Chiari Malformation Type Ii, also known as arnold-chiari malformation, is related to craniosynostosis-hydrocephalus-arnold-chiari malformation type i-radioulnar synostosis syndrome and chiari malformation type i, and has symptoms including ataxia, opisthotonus and inspiratory stridor. An important gene associated with Chiari Malformation Type Ii is FUZ (Fuzzy Planar Cell Polarity Protein). The drugs Tranexamic Acid and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and brain, and related phenotypes are agenesis of corpus callosum and hydrocephalus

NIH Rare Diseases : 54 Chiari malformation type 2 (CM type II) is a type of Chiari malformation in which both the cerebellum and brain stem tissue extend into the foramen magnum (the hole at the skull base for passing of the spinal cord). CM type II is usually accompanied by a myelomeningocele (a form of spina bifida that occurs when the spinal canal and backbone do not close before birth), which can result in partial or complete paralysis of the area below the spinal opening. While the severity of CM type II can vary greatly, it can potentially cause severe, life-threatening complications during infancy or childhood.  The exact cause of CM type II is not known but it appears to be due to defects in the brain and spinal cord that occur during fetal development. Treatment includes surgery to ease symptoms and/or stop the progression of damage to the nervous system. For most people, surgery improves or stabilizes symptoms. Some people may require more than one surgery.

OMIM : 58 Chiari malformation type II (CM2), also known as the Arnold-Chiari malformation, consists of elongation and descent of the inferior cerebellar vermis, cerebellar hemispheres, pons, medulla, and fourth ventricle through the foramen magnum into the spinal canal. CM2 is uniquely associated with myelomeningocele (open spina bifida; see 182940) and is found only in this population (Stevenson, 2004). It is believed to be a disorder of neuroectodermal origin (Schijman, 2004). For a general phenotypic description of the different forms of Chiari malformations, see Chiari malformation type I (CM1; 118420). (207950)

Wikipedia : 77 Chiari malformation (CM) is a structural defect in the cerebellum, characterized by a downward... more...

Related Diseases for Chiari Malformation Type Ii

Diseases in the Chiari Malformation family:

Chiari Malformation Type I Chiari Malformation Type Ii
Chiari Malformation Type 3 Chiari Malformation Type 4

Diseases related to Chiari Malformation Type Ii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 craniosynostosis-hydrocephalus-arnold-chiari malformation type i-radioulnar synostosis syndrome 12.5
2 chiari malformation type i 12.3
3 chiari malformation type 3 11.9
4 hydrocephalus, congenital, 1 11.8
5 chiari malformation type 4 11.7
6 corpus callosum, agenesis of 11.6
7 central sleep apnea 11.4
8 congenital laryngeal palsy 11.4
9 craniofacial dyssynostosis 11.4
10 syringomyelia, noncommunicating isolated 11.3
11 pathologic nystagmus 10.6
12 respiratory failure 10.6
13 chiari malformation 10.5
14 headache 10.5
15 sleep apnea 10.4
16 arthropathy 10.4
17 joint disorders 10.4
18 hydromyelia 10.3
19 syncope 10.3
20 spondylolysis 10.3
21 muscular atrophy 10.3
22 arachnoid cysts 10.3
23 klippel-feil syndrome 10.3
24 hydrocephalus due to congenital stenosis of aqueduct of sylvius 10.3
25 myelomeningocele 10.3
26 chronic fatigue syndrome 10.2
27 hydrocephalus 10.2
28 congenital hydrocephalus 10.2
29 dysphagia 10.1
30 hemifacial spasm 10.1
31 spina bifida aperta 10.1
32 tremor 10.1
33 myoclonus 10.1
34 spondylocostal dysostosis 1 10.1
35 distal hereditary motor neuropathies 10.1
36 hydrocele 10.1
37 bronchiectasis 10.1
38 pneumonia 10.1
39 intracranial hypotension 10.1
40 radiculopathy 10.1
41 glucosephosphate dehydrogenase deficiency 10.1
42 acute porphyria 10.1
43 pituitary hypoplasia 10.1
44 monocular esotropia 10.1
45 achalasia 10.1
46 thrombosis 10.1
47 hypopituitarism 10.1
48 intracranial hypertension 10.1
49 scoliosis 10.1
50 immunoglobulin alpha deficiency 10.1

Graphical network of the top 20 diseases related to Chiari Malformation Type Ii:



Diseases related to Chiari Malformation Type Ii

Symptoms & Phenotypes for Chiari Malformation Type Ii

Human phenotypes related to Chiari Malformation Type Ii:

33 (show all 19)
# Description HPO Frequency HPO Source Accession
1 agenesis of corpus callosum 33 frequent (33%) HP:0001274
2 hydrocephalus 33 HP:0000238
3 nystagmus 33 HP:0000639
4 ataxia 33 HP:0001251
5 muscular hypotonia 33 HP:0001252
6 dysphagia 33 HP:0002015
7 feeding difficulties 33 HP:0011968
8 bulbar signs 33 HP:0002483
9 arnold-chiari malformation 33 HP:0002308
10 generalized hypotonia 33 HP:0001290
11 limb muscle weakness 33 HP:0003690
12 cyanosis 33 HP:0000961
13 myelomeningocele 33 HP:0002475
14 opisthotonus 33 HP:0002179
15 syringomyelia 33 HP:0003396
16 inspiratory stridor 33 HP:0005348
17 cervical myelopathy 33 HP:0002318
18 gray matter heterotopia 33 HP:0002282
19 occipital neuralgia 33 HP:0012318

Symptoms via clinical synopsis from OMIM:

58
Neurologic Central Nervous System:
hydrocephalus
ataxia
spasticity
bulbar signs
headache, occipital
more
Abdomen Gastrointestinal:
dysphagia
poor feeding
choking

Head And Neck Eyes:
nystagmus

Respiratory:
inspiratory stridor
expiratory apnea with cyanosis

Clinical features from OMIM:

207950

UMLS symptoms related to Chiari Malformation Type Ii:


ataxia, opisthotonus, inspiratory stridor, muscle spasticity, headache, occipital

Drugs & Therapeutics for Chiari Malformation Type Ii

Drugs for Chiari Malformation Type Ii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 781)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 4,Not Applicable 1197-18-8 5526
2
Imiquimod Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 99011-02-6 57469
3
Aminolevulinic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 106-60-5 137
4
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 62-31-7, 51-61-6 681
5
Lorazepam Approved Phase 4 846-49-1 3958
6
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
7
Biperiden Approved, Investigational Phase 4 514-65-8 2381
8
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
9
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
10
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
11
Nitric Oxide Approved Phase 4,Phase 2,Not Applicable 10102-43-9 145068
12
Atorvastatin Approved Phase 4,Phase 1,Phase 2 134523-00-5 60823
13
Tocopherol Approved, Investigational Phase 4,Not Applicable 1406-66-2 14986
14
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-66-6 32051
15
Insulin glargine Approved Phase 4 160337-95-1
16
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
17
Adalimumab Approved Phase 4 331731-18-1 16219006
18
Dimethyl fumarate Approved, Investigational Phase 4 624-49-7 5271565 637568
19
Sodium Citrate Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 68-04-2
20
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
21
Sufentanil Approved, Investigational Phase 4,Phase 2 56030-54-7 41693
22
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
23
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 2078-54-8 4943
24
Remifentanil Approved Phase 4,Phase 1,Phase 2 132875-61-7 60815
25
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
26
Parecoxib Approved Phase 4 198470-84-7
27
Benzoyl peroxide Approved Phase 4,Not Applicable 94-36-0 7187
28
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 64-17-5 702
29
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1994-09-7, 94-09-7 2337
30
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 124-94-7 31307
31
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1401-55-4
32
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 137-58-6 3676
33
Ropivacaine Approved Phase 4,Phase 3,Phase 1,Not Applicable 84057-95-4 175805 71273
34
Acetylcholine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 51-84-3 187
35
Verteporfin Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 129497-78-5
36
Sulfadiazine Approved, Investigational, Vet_approved Phase 4,Not Applicable 68-35-9 5215
37
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 9005-49-6 46507594 772
38
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1,Early Phase 1,Not Applicable 22916-47-8 4189
39
Betamethasone Approved, Vet_approved Phase 4,Phase 1,Not Applicable 378-44-9 9782
40
Alendronate Approved Phase 4,Phase 2,Phase 3 66376-36-1, 121268-17-5 2088
41
Methylene blue Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 61-73-4
42
Tetracaine Approved, Vet_approved Phase 4,Phase 3,Phase 2 94-24-6 5411
43
Petrolatum Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 8009-03-8
44
Silicon Approved, Investigational Phase 4,Not Applicable 7440-21-3 4082203
45
Natamycin Approved Phase 4,Phase 3 7681-93-8 5281099
46
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 50-23-7 5754
47
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 50-03-3
48
Salicylic acid Approved, Investigational, Vet_approved Phase 4,Phase 2,Early Phase 1,Not Applicable 69-72-7 338
49
Methoxsalen Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 298-81-7 4114
50
Rivastigmine Approved, Investigational Phase 4,Phase 3,Not Applicable 123441-03-2 77991

Interventional clinical trials:

(show top 50) (show all 1546)
# Name Status NCT ID Phase Drugs
1 Therapeutic Effects of Monochromatic Infrared Energy Therapy on Patients With Chronic Low Back Pain Unknown status NCT01920971 Phase 4
2 TRANexamic Acid to Reduce Bleeding in BURN Surgery Unknown status NCT03113253 Phase 4 Tranexamic Acid;Placebo
3 Far Infrared Therapy on Peripheral Artery Disease in Hemodialysis Patients Unknown status NCT01095549 Phase 4
4 Reverse Phototherapy With Super Light-emitting Diode(Super-LED) for Hyperbilirubinemia in Term and Late Preterm Infants Unknown status NCT01340339 Phase 4
5 Use of a New Phototherapy Device (BBloo®) for the Treatment of Hyperbilirubinemia in the Newborn Infant Unknown status NCT02156050 Phase 4
6 Imiquimod 3.75% Cream in Combination With Cryotherapy in the Treatment of Hypertrophic Actinic Keratoses Unknown status NCT01229319 Phase 4 Cryotherapy alone to Left arm plus cryotherapy + imiquimod to Right arm;Cryotherapy alone to Left arm plus cryotherapy + imiquimod to Right arm
7 Long Term Efficacy and Safety of Eryfotona AK-NMSC® in Patients With Actinic Keratosis Unknown status NCT01656226 Phase 4
8 Comparing Different Platelet Rich Plasma (PRP) Treatment Regimens for Management of Androgenic Alopecia Unknown status NCT02999737 Phase 4
9 Maggot Debridement Therapy Versus Conventional Dressing Therapy to Treat Diabetic Foot Ulcers Unknown status NCT02816749 Phase 4
10 Superficial Basal Cell Carcinoma Treatment With Topical Photodynamic Therapy With Fractionated 5-aminolevulinic Acid 20% Versus Two Stage Methylaminolevulinate Unknown status NCT01491711 Phase 4 Methylaminolevulinate PDT in 2 sessions;Fractionated 5-aminolevulinic acid hydrochloride 20% gel PDT
11 Optimization of Procedural Sedation Protocol Used for Dental Care Delivery in People With Mental Disability Unknown status NCT02078336 Phase 4 Midazolam Mylan;Lorazepam Mylan;Valium + Akineton + Dehydrobenzperidol + Atropine sulfate
12 Far Infrared Therapy on AV Fistula Flow, Endothelial Function and Echocardiography in ESRD Patients Unknown status NCT01138254 Phase 4
13 Atorvastatin Versus Vitamin E in Treatment of Non-alcoholic Fatty Liver Disease Unknown status NCT01720719 Phase 4 atorvastatin;Vitamin E
14 Exenatide Compared With Insulin Glargine to Change Liver Fat Content in Type 2 Diabetes Unknown status NCT02303730 Phase 4 Exenatide;insulin glargine
15 The Influence of Adalimumab on Cardiovascular and Metabolic Risk in Psoriasis Unknown status NCT01088165 Phase 4 Adalimumab treatment arm;Fumaric acid esters treatment group
16 A Randomized Trial of Angiotensin Receptor bLocker,Fimasartan, in Aortic Stenosis (ALFA Trial) Unknown status NCT01589380 Phase 4 Fimasartan;Placebo
17 The Epigenetic Modification in OPRM1 on Postoperative Analgesia and Side Effect Induced by Sufentanil Unknown status NCT03135795 Phase 4 Sufentanil;dexmedetomidine;propofol;Rocuronium;sevoflurane;remifentanil;Parecoxib
18 Compliance and Tolerability of Rivastigmine Transdermal Patch 10 cm² in Patients With Probable Alzheimer's Disease. Completed NCT00731224 Phase 4 Rivastigmine transdermal patch
19 The Effects of the Rivastigmine Patch on Parkinson's Disease With Memory and/or Thinking Problems Completed NCT00988117 Phase 4 Rivastigmine Patch 9.5 cm2
20 Open-Label Safety Study to Evaluate Imiquimod Cream, 5% for Large Areas of Actinic Keratosis Completed NCT00116649 Phase 4 imiquimod cream
21 Anti Propionibacterium(P.) Acnes Activity of Epiduo® Gel Compared to Benzoyl Peroxide (BPO) 2.5% Gel Completed NCT01188538 Phase 4 Epiduo gel;BPO
22 Efficacy of Intraoperative Surgical Scrubbing in Reducing Bacterial Load After Nail Removal Surgery Completed NCT01330706 Phase 4 Polihexanide
23 Prevention of Catheter-Associated Infection With the Skin Disinfectant Octenidine Dihydrochloride Completed NCT00515151 Phase 4 0.1% Octenidine with 30% 1-propanol and 45% 2-propanol;74% Ethanol with 10% 2-propanol
24 A 24 Week, Multicenter, Open, Evaluation of the Clinical Effectiveness of the Once-daily 10 cm^2 Rivastigmine Patch Formulation in Patients With Probable Alzheimer's Disease (EXTRA) Completed NCT00622713 Phase 4 Rivastigmine transdermal patch
25 Kybella With Triamcinolone Completed NCT03361176 Phase 4 Injectable sodium deoxycholate
26 Combined Static and Dynamic Orthotic Treatment of the PIP Joint Completed NCT01914991 Phase 4
27 Effect of Systemic Ropivacaine on Hyperalgesia, Flare Reaction and Peripheral Nerve Excitability Completed NCT00900913 Phase 4 ropivacaine (Naropin)
28 Botulinum Toxin Treatment for Localized Vitiligo Completed NCT01051687 Phase 4 Botulinum toxin A
29 Prevention of Osteoporosis in Breast Cancer Survivors Completed NCT00567606 Phase 4
30 A 12 Week, Multicenter, Open Label Evaluation of Caregiver Preference, Safety and Tolerability of Exelon® Patch (Rivastigmine Transdermal) in Patients With Alzheimer's Disease Completed NCT01047579 Phase 4 Rivastigmine transdermal
31 Prospective Randomized Controlled Treatment Trial for Chronic Central Serous Chorioretinopathy Completed NCT01797861 Phase 4
32 Teriparatide (Forsteo) Treatment in Postmenopausal Women: Mechanism of Action Completed NCT01293292 Phase 4 Teriparatide
33 Nimodipine for Treating Acute Massive Cerebral Infarction Completed NCT02248233 Phase 4 Nimodipine;Saline + citicoline
34 A Clinical Trial to Study the Effects of Two Drugs, Lycopene and Prednisolone in Patients With Oral Lichen Planus Completed NCT02587117 Phase 4 lycopene;Prednisolone
35 STEP: Study of Imaging Techniques (ImaTx and DXA) in Postmenopausal Women With OstEoporosis Using Preotact (FP-008-ES) Completed NCT00583518 Phase 4 Parathyroid hormone (PTH)
36 Effect of Parathyroid Hormone (PTH) and Weight-Bearing on Bone in Spinal Cord Injury (SCI) Completed NCT00826228 Phase 4 teriparatide
37 Efficacy and Safety Study of Fentanyl Transdermal Patch for Treatment of Chronic Pain Completed NCT01902524 Phase 4 Fentanyl-TTS
38 Pain Management in Corneal Collagen Crosslinking for Keratoconus Completed NCT02867176 Phase 4 Gabapentin;Ketorolac
39 Bioequivalence of Ethylenediamine Dihydrochloride Study Completed NCT01798589 Phase 4 Ethylenediamine dihydrochloride
40 Efficiency of a Jellyfish Sting Inhibitor Sun Lotion and Protocols for Jellyfish Sting Pain Relief Completed NCT00693641 Phase 4
41 Comparative Analysis of Cost-effectiveness of Silver Dressing in Burns Completed NCT02108535 Phase 4 Nanocrystalline silver;Silver Sulphadiazine
42 Exelon Patch and Combination With Memantine Comparative Trial Completed NCT01025466 Phase 4 Rivastigmine transdermal patch (Exelon patch), memantine;Rivastigmine transdermal patch
43 Long-term Effects of Imiquimod and Diclofenac in Actinic Keratoses (LEIDA 2) Completed NCT01453179 Phase 4 Imiquimod;Diclofenac
44 Long-term Effects of Imiquimod and Diclofenac in Actinic Keratoses Completed NCT00777127 Phase 4 Imiquimod;Diclofenac
45 The Efficacy of Laser Assisted Hair Removal in the Treatment of Acne Keloidalis Nuchae; a Pilot Study Completed NCT01548898 Phase 4
46 Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus Completed NCT02858297 Phase 4 Glucosamine sulfate;triamcinolone acetonide
47 Imiquimod 5% Cream in the Treatment of External Genital or Perianal Warts in HIV+ Patients Completed NCT00761371 Phase 4 Imiquimod 5% cream
48 Clinical Trial to Evaluate the Efficacy of Smoking Cessation Completed NCT01538394 Phase 4 Varenicline;Nicotine patches;Placebo (nicotine patches)
49 Study to Assess on a Molecular Level the Influence of a 5 % Dexpanthenol Ointment in Subjects With Superficial Injuries Completed NCT00859196 Phase 4 Dexpanthenol (BAY81-2996);Placebo
50 Fractional CO2 Treatment of Acne Scars in Asians Completed NCT00748462 Phase 4

Search NIH Clinical Center for Chiari Malformation Type Ii

Genetic Tests for Chiari Malformation Type Ii

Genetic tests related to Chiari Malformation Type Ii:

# Genetic test Affiliating Genes
1 Chiari Malformation Type Ii 30

Anatomical Context for Chiari Malformation Type Ii

MalaCards organs/tissues related to Chiari Malformation Type Ii:

42
Skin, Bone, Brain, Testes, Spinal Cord, Liver, Heart

Publications for Chiari Malformation Type Ii

Articles related to Chiari Malformation Type Ii:

(show top 50) (show all 300)
# Title Authors Year
1
AQP1 Overexpression in the CSF of Obstructive Hydrocephalus and Inversion of Its Polarity in the Choroid Plexus of a Chiari Malformation Type II Case. ( 31039249 )
2019
2
Intravenous Sedation in Arnold-Chiari Malformation With Respiratory Failure. ( 30883227 )
2019
3
Encysted hydrocele of the canal of Nuck in an 11-month-old child with a past history of duodenal atresia and Arnold-Chiari malformation: A case report. ( 30681605 )
2019
4
Anesthetic management of parturients with Arnold Chiari malformation-I: a multicenter retrospective study. ( 30414718 )
2019
5
Quality of Life in Individuals Affected by Arnold Chiari Malformation: Comparison and Validation of a Measurement Instrument. ( 29173189 )
2018
6
Endoscopic Management of Arnold-Chiari Malformation Type I with or without Syringomyelia. ( 28586935 )
2018
7
Decompression for Chiari malformation type II in individuals with myelomeningocele in the National Spina Bifida Patient Registry. ( 30141752 )
2018
8
Spinal neuraxial anaesthesia for caesarean section in a parturient with type I Arnold Chiari malformation and syringomyelia. ( 30013789 )
2018
9
Sphenopalatine Ganglion Block Successfully Treats Migraines in a Type 1 Arnold Chiari Malformation Pregnant Patient: A Case Report. ( 29634560 )
2018
10
A novel proximal 3q29 chromosome microdeletion in a Chinese patient with Chiari malformation type II and Sprengel's deformity. ( 29410707 )
2018
11
Rare Cause of Type 2 Respiratory Failure: Arnold Chiari Malformation. ( 28527177 )
2017
12
Management of parturients in active labor with Arnold Chiari malformation, tonsillar herniation, and syringomyelia. ( 28217389 )
2017
13
Major depressive disorder comorbid severe hydrocephalus caused by Arnold-Chiari malformation. ( 29497204 )
2017
14
Acquired Arnold-Chiari malformation in a 16-year-old patient with hereditary angioedema. ( 28881398 )
2017
15
Contiguous triple spinal dysraphism associated with Chiari malformation Type II and hydrocephalus: an embryological conundrum between the unified theory of Pang and the unified theory of McLone. ( 26474100 )
2016
16
Short, severe dizziness attacks in a pregnant woman with type I ARNOLD-Chiari malformation. ( 26467350 )
2016
17
G6PD Deficiency with Arnold-Chiari Malformation. ( 27981932 )
2016
18
Bilateral Vocal Cord Palsy with Arnold Chiari Malformation: A Rare Case Series. ( 27790480 )
2016
19
Arnold Chiari Malformation With Sponastrime (Spondylar and Nasal Changes, With Striations of the Metaphyses) Dysplasia: A Case Report. ( 27149441 )
2016
20
Sequential morphological change of Chiari malformation type II following surgical repair of myelomeningocele. ( 26936599 )
2016
21
Chronic CSF leak causing syringomyelia and pseudo-Arnold-Chiari malformation. ( 26628487 )
2015
22
Acute porphyria in a patient with Arnold Chiari malformation. ( 25697467 )
2015
23
Arnold Chiari malformation with spina bifida: a lost opportunity of folic Acid supplementation. ( 25653995 )
2014
24
Syringomyelia and Arnold-Chiari malformation associated with neck pain and left arm radiculopathy treated with spinal manipulation. ( 25385566 )
2014
25
Chiropractic care for headaches and dizziness of a 34-year-old woman previously diagnosed with Arnold-Chiari malformation type 1. ( 25225468 )
2014
26
Arnold-Chiari Malformation Type III With Meningoencephalocele: A Case Report. ( 25024966 )
2014
27
Scapular winging in a patient with Arnold-Chiari malformation type 1 and syringomyelia. ( 24686803 )
2014
28
Focal dermal hypoplasia: report of a case with myelomeningocele, Arnold-Chiari malformation and hydrocephalus with a review of neurologic manifestations of Goltz syndrome. ( 24387693 )
2014
29
The quality of life and psychiatric morbidity in patients operated for Arnold-Chiari malformation type I. ( 23437799 )
2013
30
Novel cAMP binding protein-BP (CREBBP) mutation in a girl with Rubinstein-Taybi syndrome, GH deficiency, Arnold Chiari malformation and pituitary hypoplasia. ( 23432975 )
2013
31
Restoration of the efferent phase of the sneeze reflex after regression of an Arnold-Chiari malformation with compression of the medulla oblongata. ( 23354897 )
2013
32
Dissociated sensory loss and muscle wasting in a young male with headaches: syringomyelia with type 1 Arnold-Chiari malformation. ( 24169873 )
2013
33
Type I Arnold-Chiari malformation with bronchiectasis, respiratory failure, and sleep disordered breathing: a case report. ( 23433005 )
2013
34
Anesthesia for a patient of acromesomelic dysplasia with associated hydrocephalus, Arnold Chiari malformation and syringomyelia. ( 24249999 )
2013
35
A successful pregnancy outcome after antenatal surgical decompression of Arnold Chiari malformation. ( 24293859 )
2012
36
Unusual association of Arnold-Chiari malformation and vitamin B12 deficiency. ( 22778461 )
2012
37
A case of Arnold-Chiari malformation associated with dementia. ( 22772701 )
2012
38
Sleep-disordered breathing in children with Chiari malformation type II and myelomeningocele. ( 22564146 )
2012
39
Anesthetic management during Cesarean section in a woman with residual Arnold-Chiari malformation Type I, cervical kyphosis, and syringomyelia. ( 22439117 )
2012
40
Psychosis risk syndrome comorbid with panic attack disorder in a cannabis-abusing patient affected by Arnold-Chiari malformation type I. ( 22285366 )
2012
41
Arnold-Chiari malformation type 1 complicated by sudden onset anterior spinal artery thrombosis, tetraparesis and respiratory arrest. ( 22701030 )
2011
42
Obstructive and central sleep apnoea in Arnold-Chiari malformation: resolution following surgical decompression. ( 20835768 )
2011
43
Dexmedetomidine for an awake fiber-optic intubation of a parturient with Klippel-Feil syndrome, Type I Arnold Chiari malformation and status post released tethered spinal cord presenting for repeat cesarean section. ( 24765318 )
2011
44
Primary cerebellar tuberculoma in Arnold-Chiari malformation mimicking posterior cranial fossa tumor: the first report. ( 24353933 )
2011
45
Difficult intubation in a parturient with syringomyelia and Arnold-Chiari malformation: Use of Airtraq laryngoscope. ( 22144932 )
2011
46
Transnasal endoscopic removal of malformation of the odontoid process in a patient with type I Arnold-Chiari malformation: a case report. ( 22058600 )
2011
47
Endoscopic resection of odontoid process in Arnold Chiari malformation type II. ( 22026144 )
2011
48
Congenital stridor in the context of Chiari malformation type II: the etiological role of vernix caseosa granulomatous meningitis. ( 21961543 )
2011
49
Laugh headaches: a rare form of headache associated with type 1 Arnold-Chiari malformation. ( 21899688 )
2011
50
Clinical and radiological findings in Arnold Chiari malformation. ( 21702272 )
2010

Variations for Chiari Malformation Type Ii

ClinVar genetic disease variations for Chiari Malformation Type Ii:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 46;XY;t(1;3)(p22;q21)dn Translocation Uncertain significance

Expression for Chiari Malformation Type Ii

Search GEO for disease gene expression data for Chiari Malformation Type Ii.

Pathways for Chiari Malformation Type Ii

GO Terms for Chiari Malformation Type Ii

Sources for Chiari Malformation Type Ii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....