MCID: CHS002
MIFTS: 36

Chiasmal Syndrome

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Chiasmal Syndrome

MalaCards integrated aliases for Chiasmal Syndrome:

Name: Chiasmal Syndrome 12 15
Disorder of Optic Chiasm 12
Optic Chiasm Disorder 73
Chiasma Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5655
ICD10 33 H47.4
ICD9CM 35 377.5
SNOMED-CT 68 70476006
UMLS 73 C0155307

Summaries for Chiasmal Syndrome

Disease Ontology : 12 An optic nerve disease that is characterized by lesions of the optic chiasm, manifesting as various impairments of the sufferer's visual field according to the location of the lesion along the optic nerve.

MalaCards based summary : Chiasmal Syndrome, also known as disorder of optic chiasm, is related to adenoma and hypopituitarism. An important gene associated with Chiasmal Syndrome is DSG4 (Desmoglein 4), and among its related pathways/superpathways are Peptide ligand-binding receptors and Glucocorticoid receptor regulatory network. Affiliated tissues include pituitary, eye and lung, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia : 76 Chiasmal syndrome is the set of signs and symptoms that are associated with lesions of the optic chiasm,... more...

Related Diseases for Chiasmal Syndrome

Diseases related to Chiasmal Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 adenoma 29.7 POMC PRL SST
2 hypopituitarism 29.5 GNRH1 POMC PRL
3 pituitary tumors 29.4 POMC PRL SST
4 chromophobe adenoma 29.3 GNRH1 POMC PRL
5 hyperprolactinemia 29.1 GNRH1 POMC PRL SST
6 congenital achiasma 10.3
7 bronchus adenoma 10.1 POMC SST
8 bronchial adenomas/carcinoids childhood 10.1 POMC SST
9 acidophil adenoma 10.0 POMC SST
10 pancreatic endocrine carcinoma 10.0 POMC SST
11 ectopic cushing syndrome 10.0 POMC SST
12 adrenal gland disease 10.0 POMC SST
13 pancreas disease 10.0 POMC SST
14 glucose metabolism disease 10.0 POMC SST
15 lymphoma 10.0
16 pituitary adenoma 10.0
17 prolactin producing pituitary tumor 10.0 PRL SST
18 growth hormone secreting pituitary adenoma 10.0 PRL SST
19 spinocerebellar degeneration 10.0 PRL SST
20 pituitary adenoma 1, multiple types 10.0 PRL SST
21 mccune-albright syndrome 9.9 PRL SST
22 hypogonadotropism 9.9 GNRH1 PRL
23 thyroid carcinoma, familial medullary 9.9 POMC SST
24 fibrous dysplasia 9.9 PRL SST
25 pelvic varices 9.9 GNRH1 PRL
26 diabetes insipidus 9.9 POMC PRL
27 anovulation 9.9 GNRH1 PRL
28 adenohypophysitis 9.9 POMC PRL
29 adenomyosis 9.9 GNRH1 PRL
30 varicocele 9.9 GNRH1 PRL
31 sella turcica neoplasm 9.9 POMC PRL
32 tuberculum sellae meningioma 9.9 POMC PRL
33 hyperthyroidism 9.9 PRL SST
34 sheehan syndrome 9.9 POMC PRL
35 craniopharyngioma 9.9 GNRH1 PRL
36 acth-secreting pituitary adenoma 9.9 POMC PRL
37 multiple endocrine neoplasia, type i 9.9 PRL SST
38 abducens nerve disease 9.9 POMC PRL
39 female reproductive system disease 9.9 GNRH1 PRL
40 reproductive system disease 9.9 GNRH1 PRL
41 thyroid cancer, nonmedullary, 2 9.9 POMC SST
42 hypothyroidism, congenital, nongoitrous, 4 9.9 POMC PRL
43 pituitary hormone deficiency, combined, 2 9.9 POMC PRL
44 insulin-like growth factor i 9.9 PRL SST
45 gynecomastia 9.9 POMC PRL
46 premature ovarian failure 1 9.9 GNRH1 PRL
47 small cell cancer of the lung 9.9 POMC SST
48 polycystic ovary syndrome 9.8 GNRH1 PRL
49 thrombocytopenia 9.8
50 neuritis 9.8

Graphical network of the top 20 diseases related to Chiasmal Syndrome:



Diseases related to Chiasmal Syndrome

Symptoms & Phenotypes for Chiasmal Syndrome

MGI Mouse Phenotypes related to Chiasmal Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.63 DSG4 GNRH1 POMC PRL SST TRARG1
2 immune system MP:0005387 9.35 DSG4 GNRH1 POMC PRL SST
3 integument MP:0010771 8.92 DSG4 GNRH1 POMC PRL

Drugs & Therapeutics for Chiasmal Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Visual Outcome After Transsphenoidal Surgery for Pituitary Macroadenoma Completed NCT03363126
2 Pituitary Gland Enlargement Was First Diagnosed by Optical Coherence Tomography (OCT) Completed NCT03087682

Search NIH Clinical Center for Chiasmal Syndrome

Genetic Tests for Chiasmal Syndrome

Anatomical Context for Chiasmal Syndrome

MalaCards organs/tissues related to Chiasmal Syndrome:

41
Pituitary, Eye, Lung, Pancreas, Thyroid, Cortex, Adrenal Gland

Publications for Chiasmal Syndrome

Articles related to Chiasmal Syndrome:

(show top 50) (show all 51)
# Title Authors Year
1
Traumatic chiasmal syndrome: A meta-analysis. ( 29577103 )
2018
2
Infundibuloneurohypophysitis associated with autoimmune thrombocytopenia and chiasmal syndrome: a case report. ( 30128677 )
2018
3
Chiasmal syndrome: Clinical characteristics in patients attending an ophthalmological center. ( 29234224 )
2017
4
Isolated bitemporal hemianopsia due to traumatic chiasmal syndrome. ( 27135085 )
2016
5
Traumatic Chiasmal Syndrome: A Midline Axonal Injury. ( 27928365 )
2015
6
Early morphological recovery of the optic chiasm is associated with excellent visual outcome in patients with compressive chiasmal syndrome caused by pituitary tumors. ( 24938320 )
2015
7
Isolated complete bitemporal hemianopia in traumatic chiasmal syndrome. ( 25116786 )
2014
8
Isolated complete bitemporal hemianopia in traumatic chiasmal syndrome. ( 24212216 )
2013
9
Localized bi-nasal macular edema in optic chiasmal syndrome. ( 23548317 )
2013
10
Traumatic chiasmal syndrome. ( 22524411 )
2012
11
Optical coherence tomography documenting retinal nerve fiber loss in traumatic optic chiasmal syndrome. ( 21401907 )
2012
12
Syphilitic chorioretinitis mimicking an anterior chiasmal syndrome. ( 25389748 )
2012
13
Recurrent, transformed non-Hodgkin's lymphoma presenting as chiasmal syndrome with hyperprolactinemia and hypopituitarism. ( 20827870 )
2010
14
Relationship between visual field sensitivity loss and quadrantic macular thickness measured with Stratus-Optical coherence tomography in patients with chiasmal syndrome. ( 21225123 )
2010
15
Suprasellar pneumatocele causing a distal optic nerve and optic chiasmal syndrome. ( 17718683 )
2007
16
Clinical features associated with lesions other than pituitary adenoma in patients with an optic chiasmal syndrome: a new perspective. ( 15734029 )
2005
17
Clinical features associated with lesions other than pituitary adenoma in patients with an optic chiasmal syndrome. ( 15126157 )
2004
18
Traumatic chiasmal syndrome: a series of 19 patients. ( 12121368 )
2002
19
Absent relative afferent pupillary defect in an asymptomatic case of lateral chiasmal syndrome from cerebral aneurysm. ( 11349927 )
2001
20
Traumatic chiasmal syndrome presenting with bitemporal hemianopsia. ( 9464782 )
1998
21
Traumatic chiasmal syndrome: a feature photograph. ( 8893943 )
1996
22
Chiasmal syndrome. ( 7490416 )
1995
23
von Hippel-Lindau disease manifesting as a chiasmal syndrome. ( 7725229 )
1995
24
Traumatic chiasmal syndrome associated with midline basilar skull fractures. ( 8291599 )
1994
25
Two cases of suspected arteriosclerotic optical chiasmal syndrome. ( 2096855 )
1990
26
Familial cavernous angiomas manifesting with an acute chiasmal syndrome. ( 2774032 )
1989
27
Primary cerebral lymphoma presenting as steroid-responsive chiasmal syndrome. ( 3268148 )
1987
28
Chiasmal syndrome caused by pituitary-sellar disproportion. ( 3660211 )
1987
29
Ischemic chiasmal syndrome and hypopituitarism associated with progressive cerebrovascular occlusive disease. ( 6431771 )
1984
30
Chiasmal syndrome in sarcoidosis. ( 6870630 )
1983
31
Chiasmal syndrome. Ophthalmological and neuro-radiological aspects. ( 7067597 )
1982
32
Sudden visual loss and a chiasmal syndrome due to an intrachiasmatic vascular malformation. ( 6217219 )
1982
33
Chiasmal syndrome caused by arteriovenous malformations. ( 7065962 )
1982
34
VER analysis of the chiasmal syndrome. ( 6164754 )
1981
35
Traumatic chiasmal syndrome associated with pneumocephalus and sellar fracture. ( 7270640 )
1981
36
Traumatic chiasmal syndrome. ( 7191539 )
1980
37
Chiasmal syndrome due to metastasis. ( 475620 )
1979
38
Chiasmal syndrome in sphenoid sinus mucocele. ( 216302 )
1978
39
Chromophobe adenoma and chiasmal syndrome without enlargement of the bony sella. ( 970854 )
1976
40
Ischemic chiasmal syndrome. ( 207088 )
1976
41
Chiasmal syndrome due to intrasellar abscess. ( 962447 )
1976
42
A rare cause of the chiasmal syndrome. ( 4340829 )
1972
43
Chiasmal syndrome as a manifestation of intra-cranial neurofibromatosis. ( 5005252 )
1971
44
Preservation of the upper nasal field in the chiasmal syndrome: an anatomic explanation. ( 5381296 )
1969
45
The chiasmal syndrome. ( 4304045 )
1967
46
An arteriosclerotic chiasmal syndrome. Bitemporal hemianopia associated with fusiform dilatation of the anterior cerebral arteries. ( 5295932 )
1966
47
Suprasellar osteochondroma with chiasmal syndrome. ( 13741285 )
1961
48
Chiasmal syndrome presenting with paracentral scotoma, simulating retrobulbar neuritis. ( 13070042 )
1953
49
Ocular pathology in the chiasmal syndrome. ( 14810871 )
1951
50
Ocular pathology in the chiasmal syndrome. ( 14819190 )
1951

Variations for Chiasmal Syndrome

Expression for Chiasmal Syndrome

Search GEO for disease gene expression data for Chiasmal Syndrome.

Pathways for Chiasmal Syndrome

GO Terms for Chiasmal Syndrome

Cellular components related to Chiasmal Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.26 GNRH1 POMC PRL SST
2 secretory granule GO:0030141 8.62 POMC PRL

Biological processes related to Chiasmal Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.4 GNRH1 PRL
2 female pregnancy GO:0007565 9.37 GNRH1 PRL
3 cell-cell signaling GO:0007267 9.33 GNRH1 POMC SST
4 response to nutrient GO:0007584 9.32 PRL SST
5 response to steroid hormone GO:0048545 9.26 GNRH1 SST
6 ovulation cycle GO:0042698 8.96 GNRH1 PRL
7 regulation of signaling receptor activity GO:0010469 8.92 GNRH1 POMC PRL SST

Molecular functions related to Chiasmal Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 GNRH1 POMC PRL SST

Sources for Chiasmal Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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