MCID: CHS002
MIFTS: 35

Chiasmal Syndrome

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Chiasmal Syndrome

MalaCards integrated aliases for Chiasmal Syndrome:

Name: Chiasmal Syndrome 12 15
Disorder of Optic Chiasm 12
Optic Chiasm Disorder 73
Chiasma Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5655
ICD10 33 H47.4
ICD9CM 35 377.5
SNOMED-CT 68 194061008 70476006
UMLS 73 C0155307

Summaries for Chiasmal Syndrome

Disease Ontology : 12 An optic nerve disease that is characterized by lesions of the optic chiasm, manifesting as various impairments of the sufferer's visual field according to the location of the lesion along the optic nerve.

MalaCards based summary : Chiasmal Syndrome, also known as disorder of optic chiasm, is related to adenoma and hypopituitarism. An important gene associated with Chiasmal Syndrome is DSG4 (Desmoglein 4), and among its related pathways/superpathways is Glucocorticoid receptor regulatory network. Affiliated tissues include pituitary and eye, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 76 Chiasmal syndrome is the set of signs and symptoms that are associated with lesions of the optic chiasm,... more...

Related Diseases for Chiasmal Syndrome

Diseases related to Chiasmal Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 adenoma 28.6 POMC PRL SST
2 hypopituitarism 28.4 GNRH1 POMC PRL
3 pituitary tumors 28.4 POMC PRL SST
4 chromophobe adenoma 28.3 GNRH1 POMC PRL
5 hyperprolactinemia 27.5 GNRH1 POMC PRL SST
6 frasier syndrome 10.3 CD2AP PAX6
7 congenital achiasma 10.2
8 bronchus adenoma 10.2 POMC SST
9 acidophil adenoma 10.2 POMC SST
10 ectopic cushing syndrome 10.1 POMC SST
11 endocrine pancreas disease 10.1 POMC SST
12 pancreas disease 10.0 POMC SST
13 adrenal rest tumor 10.0 GNRH1 POMC
14 endogenous depression 10.0 GNRH1 POMC
15 cerebritis 9.9
16 tsh producing pituitary tumor 9.9 PRL SST
17 pituitary adenoma 1, multiple types 9.9 PRL SST
18 prolactin producing pituitary tumor 9.9 PRL SST
19 growth hormone secreting pituitary adenoma 9.9 PRL SST
20 lymphoma 9.8
21 pituitary adenoma 9.8
22 endometriosis of uterus 9.8 GNRH1 PRL
23 hypogonadotropism 9.8 GNRH1 PRL
24 gonadal disease 9.8 GNRH1 POMC
25 mccune-albright syndrome 9.8 PRL SST
26 fibrous dysplasia 9.8 PRL SST
27 glucose metabolism disease 9.7 POMC SST
28 adenohypophysitis 9.7 POMC PRL
29 arteriovenous malformation 9.7
30 neuritis 9.7
31 retinitis 9.7
32 macular retinal edema 9.7
33 cerebral lymphoma 9.7
34 chorioretinitis 9.7
35 scotoma 9.7
36 osteochondroma 9.7
37 aneurysm 9.7
38 cerebral aneurysms 9.7
39 sella turcica neoplasm 9.7 POMC PRL
40 tuberculum sellae meningioma 9.7 POMC PRL
41 sheehan syndrome 9.7 POMC PRL
42 acth-secreting pituitary adenoma 9.7 POMC PRL
43 anovulation 9.7 GNRH1 PRL
44 hypothyroidism, congenital, nongoitrous, 4 9.7 POMC PRL
45 central nervous system organ benign neoplasm 9.6 POMC PRL
46 varicocele 9.6 GNRH1 PRL
47 pituitary hormone deficiency, combined, 2 9.6 POMC PRL
48 gynecomastia 9.6 POMC PRL
49 craniopharyngioma 9.6 GNRH1 PRL
50 thyroid gland disease 9.5 POMC PRL

Graphical network of the top 20 diseases related to Chiasmal Syndrome:



Diseases related to Chiasmal Syndrome

Symptoms & Phenotypes for Chiasmal Syndrome

MGI Mouse Phenotypes related to Chiasmal Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.87 PAX6 POMC CD2AP SST DSG4 TRARG1
2 homeostasis/metabolism MP:0005376 9.86 POMC PRL CD2AP SST DSG4 TRARG1
3 endocrine/exocrine gland MP:0005379 9.85 PAX6 POMC PRL CD2AP DSG4 GNRH1
4 immune system MP:0005387 9.7 PAX6 POMC PRL CD2AP SST DSG4
5 integument MP:0010771 9.35 PAX6 POMC PRL DSG4 GNRH1
6 neoplasm MP:0002006 8.92 PAX6 POMC PRL GNRH1

Drugs & Therapeutics for Chiasmal Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Visual Outcome After Transsphenoidal Surgery for Pituitary Macroadenoma Completed NCT03363126
2 Pituitary Gland Enlargement Was First Diagnosed by Optical Coherence Tomography (OCT) Completed NCT03087682

Search NIH Clinical Center for Chiasmal Syndrome

Genetic Tests for Chiasmal Syndrome

Anatomical Context for Chiasmal Syndrome

MalaCards organs/tissues related to Chiasmal Syndrome:

41
Pituitary, Eye

Publications for Chiasmal Syndrome

Articles related to Chiasmal Syndrome:

(show all 50)
# Title Authors Year
1
Traumatic chiasmal syndrome: A meta-analysis. ( 29577103 )
2018
2
Chiasmal syndrome: Clinical characteristics in patients attending an ophthalmological center. ( 29234224 )
2017
3
Isolated bitemporal hemianopsia due to traumatic chiasmal syndrome. ( 27135085 )
2016
4
Traumatic Chiasmal Syndrome: A Midline Axonal Injury. ( 27928365 )
2015
5
Early morphological recovery of the optic chiasm is associated with excellent visual outcome in patients with compressive chiasmal syndrome caused by pituitary tumors. ( 24938320 )
2015
6
Isolated complete bitemporal hemianopia in traumatic chiasmal syndrome. ( 25116786 )
2014
7
Isolated complete bitemporal hemianopia in traumatic chiasmal syndrome. ( 24212216 )
2013
8
Localized bi-nasal macular edema in optic chiasmal syndrome. ( 23548317 )
2013
9
Traumatic chiasmal syndrome. ( 22524411 )
2012
10
Optical coherence tomography documenting retinal nerve fiber loss in traumatic optic chiasmal syndrome. ( 21401907 )
2012
11
Syphilitic chorioretinitis mimicking an anterior chiasmal syndrome. ( 25389748 )
2012
12
Recurrent, transformed non-Hodgkin's lymphoma presenting as chiasmal syndrome with hyperprolactinemia and hypopituitarism. ( 20827870 )
2010
13
Relationship between visual field sensitivity loss and quadrantic macular thickness measured with Stratus-Optical coherence tomography in patients with chiasmal syndrome. ( 21225123 )
2010
14
Suprasellar pneumatocele causing a distal optic nerve and optic chiasmal syndrome. ( 17718683 )
2007
15
Clinical features associated with lesions other than pituitary adenoma in patients with an optic chiasmal syndrome: a new perspective. ( 15734029 )
2005
16
Clinical features associated with lesions other than pituitary adenoma in patients with an optic chiasmal syndrome. ( 15126157 )
2004
17
Traumatic chiasmal syndrome: a series of 19 patients. ( 12121368 )
2002
18
Absent relative afferent pupillary defect in an asymptomatic case of lateral chiasmal syndrome from cerebral aneurysm. ( 11349927 )
2001
19
Traumatic chiasmal syndrome presenting with bitemporal hemianopsia. ( 9464782 )
1998
20
Traumatic chiasmal syndrome: a feature photograph. ( 8893943 )
1996
21
Chiasmal syndrome. ( 7490416 )
1995
22
von Hippel-Lindau disease manifesting as a chiasmal syndrome. ( 7725229 )
1995
23
Traumatic chiasmal syndrome associated with midline basilar skull fractures. ( 8291599 )
1994
24
Two cases of suspected arteriosclerotic optical chiasmal syndrome. ( 2096855 )
1990
25
Familial cavernous angiomas manifesting with an acute chiasmal syndrome. ( 2774032 )
1989
26
Primary cerebral lymphoma presenting as steroid-responsive chiasmal syndrome. ( 3268148 )
1987
27
Chiasmal syndrome caused by pituitary-sellar disproportion. ( 3660211 )
1987
28
Ischemic chiasmal syndrome and hypopituitarism associated with progressive cerebrovascular occlusive disease. ( 6431771 )
1984
29
Chiasmal syndrome in sarcoidosis. ( 6870630 )
1983
30
Chiasmal syndrome. Ophthalmological and neuro-radiological aspects. ( 7067597 )
1982
31
Sudden visual loss and a chiasmal syndrome due to an intrachiasmatic vascular malformation. ( 6217219 )
1982
32
Chiasmal syndrome caused by arteriovenous malformations. ( 7065962 )
1982
33
VER analysis of the chiasmal syndrome. ( 6164754 )
1981
34
Traumatic chiasmal syndrome associated with pneumocephalus and sellar fracture. ( 7270640 )
1981
35
Traumatic chiasmal syndrome. ( 7191539 )
1980
36
Chiasmal syndrome due to metastasis. ( 475620 )
1979
37
Chiasmal syndrome in sphenoid sinus mucocele. ( 216302 )
1978
38
Chromophobe adenoma and chiasmal syndrome without enlargement of the bony sella. ( 970854 )
1976
39
Ischemic chiasmal syndrome. ( 207088 )
1976
40
Chiasmal syndrome due to intrasellar abscess. ( 962447 )
1976
41
A rare cause of the chiasmal syndrome. ( 4340829 )
1972
42
Chiasmal syndrome as a manifestation of intra-cranial neurofibromatosis. ( 5005252 )
1971
43
Preservation of the upper nasal field in the chiasmal syndrome: an anatomic explanation. ( 5381296 )
1969
44
The chiasmal syndrome. ( 4304045 )
1967
45
An arteriosclerotic chiasmal syndrome. Bitemporal hemianopia associated with fusiform dilatation of the anterior cerebral arteries. ( 5295932 )
1966
46
Suprasellar osteochondroma with chiasmal syndrome. ( 13741285 )
1961
47
Chiasmal syndrome presenting with paracentral scotoma, simulating retrobulbar neuritis. ( 13070042 )
1953
48
Ocular pathology in the chiasmal syndrome. ( 14810871 )
1951
49
Ocular pathology in the chiasmal syndrome. ( 14819190 )
1951
50
The chiasmal syndrome. ( 20261923 )
1947

Variations for Chiasmal Syndrome

Expression for Chiasmal Syndrome

Search GEO for disease gene expression data for Chiasmal Syndrome.

Pathways for Chiasmal Syndrome

Pathways related to Chiasmal Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.54 POMC PRL

GO Terms for Chiasmal Syndrome

Biological processes related to Chiasmal Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.5 GNRH1 PAX6 SST
2 cell-cell signaling GO:0007267 9.33 GNRH1 POMC SST
3 keratinocyte differentiation GO:0030216 9.26 DSG4 PAX6
4 response to steroid hormone GO:0048545 8.96 GNRH1 SST
5 regulation of signaling receptor activity GO:0010469 8.92 GNRH1 POMC PRL SST

Molecular functions related to Chiasmal Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 GNRH1 POMC PRL SST

Sources for Chiasmal Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....