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MCID: CHS002
MIFTS: 29

Chiasmal Syndrome

Categories: Eye diseases, Neuronal diseases
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Aliases & Classifications for Chiasmal Syndrome

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MalaCards integrated aliases for Chiasmal Syndrome:

Name: Chiasmal Syndrome 11 14 75
Disorder of Optic Chiasm 11 33
Chiasma Syndrome 11 33
Chiasmal Optic Disorder 33
Disease of Optic Chiasm 33
Optic Chiasm Disorder 71
Intrachiasmal Lesion 33
Prechiasmal Lesion 33
Chiasmal Lesion 33

Classifications:

MalaCards categories:
Anatomical: Eye diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 31
ICD11: 33


External Ids:

Disease Ontology 11 DOID:5655
ICD9CM 34 377.5
SNOMED-CT 68 70476006
ICD10 31 H47.4
ICD11 33 927459952
UMLS 71 C0155307
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Summaries for Chiasmal Syndrome

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Disease Ontology: 11 An optic nerve disease that is characterized by lesions of the optic chiasm, manifesting as various impairments of the sufferer's visual field according to the location of the lesion along the optic nerve.

MalaCards based summary: Chiasmal Syndrome, also known as disorder of optic chiasm, is related to central diabetes insipidus and diabetes insipidus. An important gene associated with Chiasmal Syndrome is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Glucocorticoid receptor regulatory network and Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics. Affiliated tissues include eye, pituitary and brain.

Wikipedia: 75 Chiasmal syndrome is the set of signs and symptoms that are associated with lesions of the optic chiasm,... more...
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Related Diseases for Chiasmal Syndrome

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Diseases related to Chiasmal Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 central diabetes insipidus 30.3 PRL POMC
2 diabetes insipidus 30.3 PRL POMC
3 pituitary tumors 29.9 SST PRL
4 chromophobe adenoma 29.9 PRL POMC
5 arachnoiditis 29.9 POMC NEFL
6 pituitary hormone deficiency, combined, 2 29.9 PRL POMC
7 pituitary adenoma 29.8 SST PRL POMC
8 adenoma 29.8 SST PRL POMC
9 hypopituitarism 29.8 PRL POMC
10 amenorrhea 29.5 PRL POMC
11 pituitary gland disease 29.5 SST PRL POMC
12 meningioma, familial 29.4 SST PRL POMC
13 pituitary-dependent cushing's disease 29.4 SST PRL POMC
14 acromegaly 29.3 SST PRL POMC
15 hyperprolactinemia 29.3 SST PRL POMC
16 conn's syndrome 29.3 SST PRL POMC
17 bronchial adenomas/carcinoids childhood 10.1 SST POMC
18 functionless pituitary adenoma 10.1 SST POMC
19 optic nerve disease 10.1
20 scotoma 10.1
21 thyroid dyshormonogenesis 2a 10.1 SST POMC
22 cranial nerve malignant neoplasm 10.1 SST POMC
23 pancreatic endocrine carcinoma 10.1 SST POMC
24 autonomic nervous system benign neoplasm 10.1 SST POMC
25 peripheral nervous system benign neoplasm 10.1 SST POMC
26 thyroid gland medullary carcinoma 10.1 SST POMC
27 pancreatic cystadenoma 10.0 SST POMC
28 gastrinoma 10.0 SST POMC
29 islet cell tumor 10.0 SST POMC
30 hyperinsulinemic hypoglycemia 10.0 SST POMC
31 cranial nerve disease 10.0 POMC NEFL
32 cerebral degeneration 10.0 POMC NEFL
33 irritable bowel syndrome 10.0 SST POMC
34 small cell cancer of the lung 9.9 SST POMC
35 tuberculum sellae meningioma 9.9 PRL POMC
36 sella turcica neoplasm 9.9 PRL POMC
37 prolactin producing pituitary tumor 9.9 PRL POMC
38 abducens palsy 9.9 PRL POMC
39 melanotic neurilemmoma 9.9 PRL POMC
40 sheehan syndrome 9.9 PRL POMC
41 hypothalamic disease 9.9 PRL POMC
42 melancholia 9.9 PRL POMC
43 partial third-nerve palsy 9.9 PRL POMC
44 sexual sadism 9.9 PRL POMC
45 hypothyroidism, congenital, nongoitrous, 4 9.9 PRL POMC
46 acth deficiency, isolated 9.9 PRL POMC
47 cranial nerve palsy 9.9 PRL POMC
48 pituitary hypoplasia 9.9 PRL POMC
49 inappropriate adh syndrome 9.9 PRL POMC
50 van maldergem syndrome 1 9.9 PRL POMC

Graphical network of the top 20 diseases related to Chiasmal Syndrome:



Diseases related to Chiasmal Syndrome
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Symptoms & Phenotypes for Chiasmal Syndrome

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Drugs & Therapeutics for Chiasmal Syndrome

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intraoperative Continuous Flash Visual Evoked Potentials Monitoring During Minimally Invasive Endoscopic Skull Base Surgery, a Novel Approach to Improve Patient Outcome Unknown status NCT04068220
2 Visual Outcome After Transsphenoidal Surgery for Pituitary Macroadenoma Completed NCT03363126

Search NIH Clinical Center for Chiasmal Syndrome

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Genetic Tests for Chiasmal Syndrome

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Anatomical Context for Chiasmal Syndrome

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Organs/tissues related to Chiasmal Syndrome:

MalaCards : Eye, Pituitary, Brain
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Publications for Chiasmal Syndrome

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Articles related to Chiasmal Syndrome:

(show top 50) (show all 167)
# Title Authors PMID Year
1
Trans-eyebrow supraorbital endoscope-assisted keyhole approach to suprasellar meningioma in pediatric patient: case report and literature review. 62
36104809 2022
2
Optical coherence tomography and visual evoked potentials in evaluation of optic chiasm decompression. 62
35136174 2022
3
A case of acute optic neuritis during pregnancy treated by membrane-based therapeutic plasma exchanges without systemic anticoagulation. 62
34099404 2021
4
Long term predictive ability of preoperative retinal nerve fiber layer thickness in visual prognosis after chiasmal decompression surgery. 62
34119898 2021
5
Primary diffuse large B cell lymphoma of the optic chiasm in an immunocompetent patient. 62
34330724 2021
6
Direct and transsynaptic retrograde degeneration and optic nerve head microvascular changes in patients with hemianopia. 62
32811169 2021
7
Ischemic chiasmal syndrome associated with posterior communicating artery (PCoA) and tuberothalamic artery (TA) infarction: a case report. 62
33205375 2021
8
[Chiasmatic syndrome]. 62
33183775 2021
9
Wilbrand's Knee: To Be or Not to Be a Knee? 62
32796340 2020
10
Neuro-Ophthalmic Manifestations of Intracranial Malignancies. 62
32282510 2020
11
Acute monocular nasal hemianopia following a mild traumatic brain injury: A case report. 62
32791737 2020
12
Repeat Resection of a Cavernous Malformation of the Optic Nerve/Chiasm via a Frontotemporal Approach: 2-Dimensional Operative Video. 62
31294450 2020
13
Sudden bilateral vision loss due to third ventricular cavernous angioma with intratumoral hemorrhage - case report. 62
31842792 2019
14
Pituitary abscess: two case reports. 62
31759391 2019
15
Infundibuloneurohypophysitis associated with autoimmune thrombocytopenia and chiasmal syndrome: a case report. 62
30128677 2019
16
Agreement of driving simulator and on-road driving performance in patients with binocular visual field loss. 62
30251198 2018
17
Pituitary Tuberculoma. 62
29866234 2018
18
Complete evaluation of pituitary tumours in a single tertiary care institution. 62
29532430 2018
19
Traumatic chiasmal syndrome: A meta-analysis. 62
29577103 2018
20
A multidisciplinary approach for the treatment of young patients with suprasellar osteochondroma. 62
29067502 2018
21
Chiasmal syndrome: Clinical characteristics in patients attending an ophthalmological center. 62
29234224 2017
22
[A Case of Lymphocytic Adenohypophysitis Presenting Visual Disturbance in the Third Trimester of Pregnancy]. 62
28202834 2017
23
Isolated bitemporal hemianopsia due to traumatic chiasmal syndrome. 62
27135085 2016
24
Traumatic Chiasmal Syndrome: A Midline Axonal Injury. 62
27928365 2015
25
Cavernous malformation of the optic chiasm: An uncommon location. 62
25949848 2015
26
Early morphological recovery of the optic chiasm is associated with excellent visual outcome in patients with compressive chiasmal syndrome caused by pituitary tumors. 62
24938320 2015
27
Isolated complete bitemporal hemianopia in traumatic chiasmal syndrome. 62
25116786 2014
28
Assessing visual acuity across five disease types: ETDRS charts are faster with clinical outcome comparable to Landolt Cs. 62
24867313 2014
29
Neuro-ophthalmologic features of chordoid glioma. 62
24113763 2014
30
Isolated complete bitemporal hemianopia in traumatic chiasmal syndrome. 62
24212216 2013
31
[Bitemporal hemianopia as presenting sign of severe ethambutol toxicity]. 62
24094504 2013
32
Localized bi-nasal macular edema in optic chiasmal syndrome. 62
23548317 2013
33
Traumatic chiasmal syndrome. 62
22524411 2012
34
Optical coherence tomography documenting retinal nerve fiber loss in traumatic optic chiasmal syndrome. 62
21401907 2012
35
Predictors for visual dysfunction in nonfunctioning pituitary adenomas - implications for neurosurgical management. 62
22747829 2012
36
Uncommon cavernous malformation of the optic chiasm: a case report. 62
22892383 2012
37
Acute, monocular vision loss from Rathke's cleft cyst. 62
22336223 2012
38
Pituitary metastasis revealed by a chiasma syndrome. 62
22563996 2012
39
Syphilitic chorioretinitis mimicking an anterior chiasmal syndrome. 62
25389748 2012
40
Relationship between visual field sensitivity loss and quadrantic macular thickness measured with Stratus-Optical coherence tomography in patients with chiasmal syndrome. 62
21225123 2010
41
Functional impairments caused by chiasma syndromes prior to and following transsphenoidal pituitary adenoma surgery. 62
20454981 2010
42
[Craniopharyngioma--a "geographical malignant" tumour]. 62
20715005 2010
43
[Case of traumatic chiasmal syndrome]. 62
20593659 2010
44
Recurrent, transformed non-Hodgkin's lymphoma presenting as chiasmal syndrome with hyperprolactinemia and hypopituitarism. 62
20827870 2010
45
[Pituitary apoplexy and severe bilateral visual loss: a case report]. 62
19616868 2009
46
Suprasellar pneumatocele causing a distal optic nerve and optic chiasmal syndrome. 62
17718683 2007
47
[Nerve fibre bundle defects in a pre-chiasmal lesion]. 62
17309013 2007
48
[Visual functional changes in patients with pituitary adenoma: results of transnasal-transsphenoidal tumor removal]. 62
16826780 2006
49
A traumatic bitemporal hemianopia with macular sparing. 62
16681064 2005
50
[Optochiasmal cavernoma: a rare cause of unilateral visual loss]. 62
16106818 2005
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Variations for Chiasmal Syndrome

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Expression for Chiasmal Syndrome

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Search GEO for disease gene expression data for Chiasmal Syndrome.
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Pathways for Chiasmal Syndrome

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Pathways related to Chiasmal Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Glucocorticoid receptor regulatory network 61
10.84 PRL POMC
2
Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics 60
9.92 PRL POMC
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GO Terms for Chiasmal Syndrome

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Molecular functions related to Chiasmal Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.1 SST PRL POMC
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Sources for Chiasmal Syndrome

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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